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Search Results for " solid tumors "

Targets Recommended: p97

113

抑制剂 & 化合物

3

天然产物

1

化合物库

9

重组蛋白

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Cat. No.	Product Name
L9700	内质网应激化合物库		193 compounds
	193 个内质网应激相关的化合物集合，可用于高通量和高内涵筛选；

化合物库

内质网应激化合物库

Cat.No: L9700

Compounds: 193

Cat. No.	Product Name	Target	Signaling Pathways
T6796	CB-5083 CB5083,CB 5083	p97	Ubiquitination
	CB-5083 是一种有效的、选择性的、可口服的 p97 AAA ATPase 抑制剂，IC50为 11 nM。
T13044	Mevociclib SY-1365	CDK	Cell Cycle/Checkpoint
	Mevociclib (SY-1365) 是一种高效选择性 CDK7抑制剂，Ki 值为 17.4 nM。它具有抗血液肿瘤和侵袭性实体肿瘤作用，有抗增殖和凋亡活性。
T9430	Venadaparib NOV140101,IDX-1197	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Venadaparib (NOV140101) 是一种选择性和具有口服活性的 PARP 抑制剂，对 PARP1和 PARP2的 IC50分别为 1.4 和 1.0 nM。它可防止 DNA 单链断裂 (SSB) 的修复，可研究实体瘤。
T3124	Carbendazim Bavistin,Carbendazole,多菌灵,Mercarzole	Antifungal	Microbiology/Virology
	Carbendazim (Mercarzole) 是一种具有抗肿瘤活性的苯并咪唑衍生物，可用于癌症研究。它是一种口服广谱苯并咪唑杀菌剂，可作为真菌疾病研究的杀虫剂。
T7318	Elimusertib BAY-1895344	ATM/ATR	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	Elimusertib (BAY-1895344) 是一种可口服的选择性ATR 抑制剂，IC50值为 7 nM。它具有抗肿瘤活性，可研究实体瘤和淋巴瘤。
T2325	Neratinib HKI-272,来那替尼	EGFR; HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Neratinib (HKI-272) 是一种酪氨酸激酶受体抑制剂，可以抑制 HER2 和 EGFR (IC50=59/92 nM)，具有不可逆性和口服活性。Neratinib 具有抗肿瘤活性，可以用于治疗乳腺癌。
T1601	Lomustine CCNU,NSC 79037,洛莫司汀	Apoptosis; Others; DNA Alkylator/Crosslinker; DNA Alkylation; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Others
	Lomustine (NSC-79037) 是一种具有抗肿瘤活性的 DNA 烷化剂。
T26978	CEP-40125 RXDX-107	DNA Alkylation	DNA Damage/DNA Repair
	CEP-40125 (RXDX-107) 是一种 DNA 烷基剂，可用于研究晚期实体瘤。
T2619	CH5132799	PI3K; mTOR	PI3K/Akt/mTOR signaling
	CH5132799 是一种选择性的 I 类PI3K 抑制剂。它能够抑制 PI3Kα，其 IC50=14 nM。
T71924L	AC 7739	Microtubule Associated	Cytoskeletal Signaling
	AC 7739 是一种微管蛋白结合剂，具有抗癌抗肿瘤活性，抑制晚期实体瘤和原位移植肿瘤。
T36395	Trotabresib CC-90010	Epigenetic Reader Domain	Chromatin/Epigenetic
	Trotabresib (CC-90010) 是一种具有口服活性的 BET 抑制剂，可用于晚期实体瘤的研究。
T76706	Varlilumab CDX-1127	TNF	Apoptosis
	Varlilumab (CDX-1127) 是一种新型的人 IgG1 抗 CD27 单克隆抗体。Varlilumab 具有抗肿瘤活性，可用于研究晚期实体肿瘤。
T15009	Elacytarabine 5'-Oleoyl cytosine arabinoside,5'-O-(Elaidoyl) 1-beta-D-arabinofuranosylcytosine,5'-Oleoyl cytarabine,艾西拉滨,CP 4055	Others	Others
	Elacytarabine (M7594 0037) 是核苷类似物阿糖胞苷的一种脂质缀合衍生物。Elacytarabine (M7594 0037) (CP 4055) 是一种抗肿瘤药物，在实体瘤中具有细胞毒性。
T9901A-008	Volociximab Eos 200-4,M200	Integrin	Cytoskeletal Signaling
	Volociximab (M200) 是一种靶向 α5β1 整合素的 IgG4 单克隆抗体，具有抗血管生成、抗肿瘤和抗癌活性，可抑制兔子 VX2 肿瘤的生长，用于研究实体瘤。
T12433	PF-06952229 PF06952229	TGF-beta/Smad	Stem Cells
	PF-06952229 是 TGFβRI 的选择性抑制剂。 PF-06952229 可用于治疗实体瘤，特别是转移性乳腺癌的研究。
T71137	Simmitecan hydrochloride	Topoisomerase	DNA Damage/DNA Repair
	Simmitecan hydrochloride 是一种喜树碱衍生物，是一种拓扑异构酶 I 抑制剂，具有抗癌活性，可用于研究是实体瘤。
T7708	DL-Buthionine-(S,R)-sulfoximine Butionine sulfoximine,丁基硫,NSC 381100,D,L-Buthionine-(S,R)-sulfoximine	Others; Ferroptosis	Apoptosis; Others
	DL-Buthionine-(S,R)-sulfoximine (Butionine sulfoximine) 是 γ-谷氨酰半胱氨酸合成酶的抑制剂，用于治疗实体瘤。
T79157	Pimicotinib ABSK021,ABSK-021	c-Fms; Others	Others; Tyrosine Kinase/Adaptors
	Pimicotinib (ABSK021) 为一种有效的 CSF1R 抑制剂，具抗肿瘤活性，可用于研究晚期实体瘤。
T71399	Plogosertib CYC140	PLK	Cell Cycle/Checkpoint
	Plogosertib (CYC140) 是一种具有口服活性、选择性、高效性和 ATP 竞争性的 PLK1 抑制剂，IC50 值为 3 nM。Plogosertib 具有抗增殖和抗癌活性，可用于研究实体瘤和血液肿瘤。
T68144	Spiroplatin	Others	Others
	Spiroplatin（TNO-6）是一种新型含铂类似物，具有抗肿瘤活性，常用用于研究实体肿瘤。
T2113	PHA-793887 PHA 793887,PHA793887	Apoptosis; CDK	Apoptosis; Cell Cycle/Checkpoint
	PHA-793887 是一种ATP 竞争性的CDK 抑制剂，可抑制 Cdk2、Cdk1、Cdk4 和 Cdk9 的活性，IC50值分别为 8 nM、60 nM、62 nM 和 138 nM，同时可抑制糖原合酶激酶 3β，IC50值为 79 nM。
T9929	Ramucirumab	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Ramucirumab 是一种人 VEGFR-2 拮抗剂，具有抗实体瘤活性。它是人源化单克隆抗体，能够与 VEGFR-2 结合，阻碍 VEGFR 配体 VEGF-A，VEGF-C 和 VEGF-D 结合。
T2503	PAC-1 Procaspase activating compound 1	Apoptosis; Caspase; Autophagy	Apoptosis; Autophagy; Proteases/Proteasome
	PAC-1 (Procaspase activating compound 1) 是一种 procaspase-3激活剂，诱导癌细胞凋亡，EC50为 2.08 μM，可用于研究淋巴瘤、黑色素瘤、实体瘤、乳腺癌和胸癌等治疗的试验。
T40199	Tulmimetostat CPI-0209	Histone Methyltransferase	Chromatin/Epigenetic
	Tulmimetostat (CPI-0209) 是一种具有口服活性的 EZH1/EZH2 抑制剂。Tulmimetostat 有抗肿瘤活性，用于研究卵巢癌和晚期实体瘤。
T9901A-002	Enoblituzumab MGA271,TJ-271	Others	Others
	Enoblituzumab 是一种人源化 IgG1κ 单克隆抗体，可以识别人 B7-H3 蛋白，可用于研究非小细胞肺癌（NSCLC）等实体肿瘤。
T13519	6-Aminochrysene 6-Chrysenamine	Others	Others
	6-Aminochrysene (6-Chrysenamine) 是几种实体实验性肿瘤生长的抑制剂，可用于脾肿大、乳腺癌和骨髓性白血病的研究。
T74698	RMC-6236 RMC6236	Ras	GPCR/G Protein; MAPK
	RMC-6236 是一种 RAS(ON)MULTI 抑制剂，具有抗癌活性，可用于研究晚期恶性实体瘤和结直肠癌。
T77138	Ragifilimab INCAGN-01876,INCAGN-1876,CM-701	TNF	Apoptosis
	Ragifilimab (INCAGN-1876)，一种针对糖皮质激素诱导的TNFR相关蛋白(GITR)的单克隆抗体激动剂，适用于晚期或转移性实体瘤的研究。
T63260	Snail/HDAC-IN-1	Apoptosis; Antifungal	Apoptosis; Microbiology/Virology
	Snail/HDAC-IN-1是一种Snail/HDAC 抑制剂剂，具有抗菌抗癌活性，可降低Snail蛋白的表达，诱导细胞凋亡，可用于研究实体肿瘤。
T76671	Amatuximab MORab-009	Others	Others
	Amatuximab (MORab-009) 是一种人源化针对细胞表面间皮素 (MSLN) 的嵌合 IgG1/k 单抗，具有抗肿瘤活性，可用于治疗实体肿瘤。
T15168L	DRF-1042 HCl DRF-1042 HCl（200619-13-2 Free base）	Topoisomerase	DNA Damage/DNA Repair
	DRF-1042 HCl 是一种具有口服活性的喜树碱类似物，具有抗肿瘤活性，抑制 DNA 拓扑异构酶 I，可用于研究难治性实体瘤。
T77750	Rosmantuzumab OMP-131R10	Others	Others
	Rosmantuzumab (OMP-131R10) 是一种人源化抗 R-spondin 3 (RSPO3)单克隆抗体。Rosmantuzumab 具有潜在的抗肿瘤活性，可用于研究晚期复发难治性实体瘤。
T81263	RMC-7977	Ras	GPCR/G Protein; MAPK
	RMC-7977 是一种高选择性的 KRAS、HRAS 和 NRAS 活性（GTP 结合）形式的抑制剂，具有抗癌活性，可用于研究KRAS G12C突变的实体瘤。
T13688	Eribulin ER-086526,E7389,B1939	Microtubule Associated; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Cytoskeletal Signaling
	Eribulin (B1939) 是非紫杉烷微管动力学抑制剂，具有抗癌活性，通过防止细胞分裂过程中微管的延长和缩短来抑制微管蛋白亚基的聚合。Eribulin 可用于研究转移性乳腺癌和实体瘤。
T73140	MAT2A-IN-9	Methionine Adenosyltransferase (MAT)	Chromatin/Epigenetic
	MAT2A-IN-9 是一种 2-oxoquinazoline 衍生物，是一种有效的MAT2A (蛋氨酸腺苷转移酶 2A) 抑制剂。MAT2A-IN-9 具有抗肿瘤活性可用于治疗淋巴瘤和实体瘤。
T2365	Pilaralisib SAR245408,XL-147	PI3K	PI3K/Akt/mTOR signaling
	Pilaralisib (XL-147) 是一种有效的、选择性的 I 类PI3Ks 抑制剂，能够抑制 PI3Kα (IC50:39 nM)，PI3Kβ (IC50:383 nM)，PI3Kγ (IC50:23 nM) 和 PI3Kδ (IC50:36 nM)。
T2709	TAK-901 TAK901	JAK; CDK; Src; Aurora Kinase	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	TAK-901是一种多靶点的极光激酶抑制剂，对极光激酶 A 和 B 的 IC50值分别为 21 和 15 nM。它用于研究淋巴瘤、骨髓纤维化、多发性骨髓瘤、骨髓化生和晚期实体瘤等治疗的试验。
T72953	Zidesamtinib NVL-520	ROS Kinase	Tyrosine Kinase/Adaptors
	Zidesamtinib (NVL-520)是一种具有口服活性、选择性、高效性和可透过血脑屏障的 ROS1 融合和抗性突变抑制剂，抑制 ROS1 和 ROS1 G2032R ，可用于研究非小细胞肺癌和实体瘤。
T6084	Rabusertib LY2603618,IC-83	Chk; PDK; Autophagy	Autophagy; Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling
	Rabusertib (IC-83) 是一种有效的选择性的Chk1抑制剂，IC50为 7 nM。它有潜在的化学增强活性，用于各种癌症和肿瘤治疗的试验。
T12040	Milademetan RAIN-32,DS-3032,DS3032b	Mdm2; Others	Apoptosis; Others
	Milademetan (DS-3032) 是一种具有口服活性和有效性的 MDM2 抑制剂，具有抗肿瘤活性，诱导 G1 细胞周期阻滞、衰老和凋亡。Milademetan 可用于研究急性髓系白血病和实体肿瘤。
T83970	IMMH 010 maleate YPD-30 maleate	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	IMMH 010 maleate (YPD-30 maleate) 是一种可口服的程序性细胞死亡配体 1 抑制剂，具有潜在的抗肿瘤活性，可用于研究神经系统疾病和晚期恶性实体瘤。
T1890	Pracinostat SB939	Apoptosis; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Pracinostat (SB939) 是一种组蛋白去乙酰化酶抑制剂，对 HDACs 的IC50值为 40-140 nM，可用于研究癌症。
T35392	Tiragolumab RO 7092284,RG6058-10,MTIG-7192A,RG6058-11,RG-6058	Others	Others
	Tiragolumab(MTIG-7192A) 是一种靶向 T 细胞免疫球蛋白和 ITIM 结构域 (TIGIT) 的单克隆抗体。Tiragolumab (anti-TIGIT) 常与 PD-L1 抑制剂 Atezolizumab 联合使用用来治疗像非小细胞肺癌类的实体恶性肿瘤。
T3504L	AZD5153	Epigenetic Reader Domain	Chromatin/Epigenetic
	AZD5153 是一种可逆的溴结构域和末端外家族蛋白 BRD4 的抑制剂，具有抗肿瘤活性，通过改变 BRD4 染色体景观和调节 HCC 细胞的转录组来抑制肝癌发生，可用于研究淋巴瘤和实体瘤。
T0078L	Lapatinib ditosylate monohydrate Lapatinib ditosylate monohydrate,Lapatinib ditoluenesulfonate monohydrate,Lapatinib tosilate hydrate,Lapatinib tosilate,Tykerb,二甲苯磺酸拉帕替尼单水合物,Tyverb	EGFR; Ferroptosis; Autophagy	Angiogenesis; Apoptosis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Lapatinib ditosylate (Lapatinib tosilate) monohydrate 是一种有效的 EGFR 和 ErbB2 抑制剂，对 EGFR 和 ErbB2的 IC50值分别为 10.8 和 9.2 nM。它用于治疗晚期乳腺癌和其他实体瘤。
T63333	Uplarafenib B-Raf IN 10	Raf	MAPK
	Uplarafenib (B-Raf IN 10) 是一种强效的 BRAF 抑制剂，其 IC50 在 50-100 nM 之间。B-Raf IN 10 具有抗肿瘤活性，可能不会影响细胞增殖和分化，可用于研究实体瘤。
T2156	WP1066	Apoptosis; JAK; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	WP1066 是一种新型JAK2和STAT3抑制剂，对 STAT5 和 ERK1/2 也起作用。它用于研究黑色素瘤、脑癌、实体瘤和中枢神经系统肿瘤治疗。
T6157	Devimistat CPI-613,辛酸,CPI613,CPI 613,6,8-Bis(benzylthio)octanoic acid	Apoptosis; Dehydrogenase; Mitochondrial Metabolism	Apoptosis; Metabolism
	Devimistat (6,8-Bis(benzylthio)octanoic acid) 是一种线粒体代谢抑制剂，还是一种lipoic acid 拮抗剂，能阻断线粒体能量代谢，诱导多种癌细胞凋亡。
T11500L	GSK3368715 dihydrochloride EPZ019997 dihydrochloride,GSK3368715 2HCl,EPZ019997 2HCl	Histone Methyltransferase	Chromatin/Epigenetic
	GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) 是一种具有口服活性和高效性的 I 型蛋白精氨酸甲基转移酶 (PRMTs) 抑制剂，具有抗癌和抗肿瘤活性，抑制PRMT1，PRMT3，PRMT4，PRMT6，PRMT8的活性，可用于研究晚期实体肿瘤。
T27342L	Flurocitabine HCl Flurocitabine HCl(37717-21-8 Free base)	Others	Others
	Flurocitabine HCl 是阿糖胞苷的氟化酸酐类似物，在体内部分水解成两种活性抗肿瘤物质 (阿拉伯糖基-氟尿嘧啶 (ara-FC) 和阿拉伯糖基-氟尿嘧啶 (ara-FU))。Flurocitabine HCl 在急性白血病和实体瘤的 I 期研究中具显示出抗肿瘤活性。

化合物

Cat.No: T6796

Synonym: CB5083,CB 5083

Target: p97

Cat.No: T13044

Synonym: SY-1365

Target: CDK

Cat.No: T9430

Synonym: NOV140101,IDX-1197

Target: PARP

Cat.No: T3124

Synonym: Bavistin,Carbendazole,多菌灵,Mercarzole

Target: Antifungal

Cat.No: T7318

Synonym: BAY-1895344

Target: ATM/ATR

Cat.No: T2325

Synonym: HKI-272,来那替尼

Target: EGFR, HER

Cat.No: T1601

Synonym: CCNU,NSC 79037,洛莫司汀

Target: Apoptosis, Others, DNA Alkylator/Crosslinker, DNA Alkylation, Autophagy

Cat.No: T26978

Synonym: RXDX-107

Target: DNA Alkylation

Cat.No: T2619

Target: PI3K, mTOR

Cat.No: T71924L

Target: Microtubule Associated

Cat.No: T36395

Synonym: CC-90010

Target: Epigenetic Reader Domain

Cat.No: T76706

Synonym: CDX-1127

Target: TNF

Cat.No: T15009

Synonym: 5'-Oleoyl cytosine arabinoside,5'-O-(Elaidoyl) 1-beta-D-arabinofuranosylcytosine,5'-Oleoyl cytarabine,艾西拉滨,CP 4055

Target: Others

Cat.No: T9901A-008

Synonym: Eos 200-4,M200

Target: Integrin

Cat.No: T12433

Synonym: PF06952229

Target: TGF-beta/Smad

Simmitecan hydrochloride

Cat.No: T71137

Target: Topoisomerase

DL-Buthionine-(S,R)-sulfoximine

Cat.No: T7708

Synonym: Butionine sulfoximine,丁基硫,NSC 381100,D,L-Buthionine-(S,R)-sulfoximine

Target: Others, Ferroptosis

Cat.No: T79157

Synonym: ABSK021,ABSK-021

Target: c-Fms, Others

Cat.No: T71399

Synonym: CYC140

Target: PLK

Cat.No: T68144

Target: Others

Cat.No: T2113

Synonym: PHA 793887,PHA793887

Target: Apoptosis, CDK

Cat.No: T9929

Target: VEGFR

Cat.No: T2503

Synonym: Procaspase activating compound 1

Target: Apoptosis, Caspase, Autophagy

Cat.No: T40199

Synonym: CPI-0209

Target: Histone Methyltransferase

Cat.No: T9901A-002

Synonym: MGA271,TJ-271

Target: Others

6-Aminochrysene

Cat.No: T13519

Synonym: 6-Chrysenamine

Target: Others

Cat.No: T74698

Synonym: RMC6236

Target: Ras

Cat.No: T77138

Synonym: INCAGN-01876,INCAGN-1876,CM-701

Target: TNF

Snail/HDAC-IN-1

Cat.No: T63260

Target: Apoptosis, Antifungal

Cat.No: T76671

Synonym: MORab-009

Target: Others

Cat.No: T15168L

Synonym: DRF-1042 HCl（200619-13-2 Free base）

Target: Topoisomerase

Cat.No: T77750

Synonym: OMP-131R10

Target: Others

Cat.No: T81263

Target: Ras

Cat.No: T13688

Synonym: ER-086526,E7389,B1939

Target: Microtubule Associated, ADC Cytotoxin

Cat.No: T73140

Target: Methionine Adenosyltransferase (MAT)

Cat.No: T2365

Synonym: SAR245408,XL-147

Target: PI3K

Cat.No: T2709

Synonym: TAK901

Target: JAK, CDK, Src, Aurora Kinase

Cat.No: T72953

Synonym: NVL-520

Target: ROS Kinase

Cat.No: T6084

Synonym: LY2603618,IC-83

Target: Chk, PDK, Autophagy

Cat.No: T12040

Synonym: RAIN-32,DS-3032,DS3032b

Target: Mdm2, Others

IMMH 010 maleate

Cat.No: T83970

Synonym: YPD-30 maleate

Target: PD-1/PD-L1

Cat.No: T1890

Synonym: SB939

Target: Apoptosis, HDAC

Cat.No: T35392

Synonym: RO 7092284,RG6058-10,MTIG-7192A,RG6058-11,RG-6058

Target: Others

Cat.No: T3504L

Target: Epigenetic Reader Domain

Lapatinib ditosylate monohydrate

Cat.No: T0078L

Synonym: Lapatinib ditosylate monohydrate,Lapatinib ditoluenesulfonate monohydrate,Lapatinib tosilate hydrate,Lapatinib tosilate,Tykerb,二甲苯磺酸拉帕替尼单水合物,Tyverb

Target: EGFR, Ferroptosis, Autophagy

Cat.No: T63333

Synonym: B-Raf IN 10

Target: Raf

Cat.No: T2156

Target: Apoptosis, JAK, STAT

Cat.No: T6157

Synonym: CPI-613,辛酸,CPI613,CPI 613,6,8-Bis(benzylthio)octanoic acid

Target: Apoptosis, Dehydrogenase, Mitochondrial Metabolism

GSK3368715 dihydrochloride

Cat.No: T11500L

Synonym: EPZ019997 dihydrochloride,GSK3368715 2HCl,EPZ019997 2HCl

Target: Histone Methyltransferase

Flurocitabine HCl

Cat.No: T27342L

Synonym: Flurocitabine HCl(37717-21-8 Free base)

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T5724	Neogambogic acid neo-gambogic acid,新藤黄酸	Apoptosis; Others; Antibacterial	Apoptosis; Microbiology/Virology; Others
	Neogambogic acid 是藤黄的有效成分，可诱导细胞凋亡并具有抗癌作用。它有效抑制耐甲氧西林的金黄色葡萄球菌。
T40519	Indicine N-oxide (+)-Indicine N-oxide,Indicine N-oxide,NSC132319	Others	Others
	Indicine N-oxide (NSC 132319), a pyrrolizidine alkaloid, serves as an antitumor agent in pediatric cancer and solid tumors research.
T83110	Angulatin K
	Angulatin K为Celastrus angulatus根皮中发现的天然倍半萜多元醇酯。

天然产物

Neogambogic acid

Cat.No: T5724

Synonym: neo-gambogic acid,新藤黄酸

Target: Apoptosis, Others, Antibacterial

Indicine N-oxide

Cat.No: T40519

Synonym: (+)-Indicine N-oxide,Indicine N-oxide,NSC132319

Target: Others

Cat.No: T83110

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00008	CCL5 Protein, Mouse, Recombinant (hFc) D17S136E,RANTES,SCYA5,SIS-δ,Ccl5,SISd,eoCP,MuRantes,TCP228,S...	Mouse	HEK293 Cells
	The CCR5 and the CCL5 ligand have been detected in some hematological malignancies, lymphomas, and a great number of solid tumors, but extensive studies on the role of the CCL5/CCR axis were performed only in a limited number of cancers. CCL5 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 35.2 kDa and the accession number is P30882.
TMPK-00009	CCL5 Protein, Human, Recombinant (His & Avi), Biotinylated RANTES,SIS-δ,D17S136E,TCP228,eoCP,SIS-delta,SCYA5,CCL5,SISd,...	Human	E. coli
	The CCR5 and the CCL5 ligand have been detected in some hematological malignancies, lymphomas, and a great number of solid tumors, but extensive studies on the role of the CCL5/CCR axis were performed only in a limited number of cancers. CCL5 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in E. coli expression system with N-His-Avi tag. The predicted molecular weight is 10.89 kDa and the accession number is P13501.
TMPK-01081	Glypican 2/GPC2 Protein, Mouse, Recombinant (His) Cerebroglycan,2410016G05Rik,GPC2,Glypican-2	Mouse	HEK293 Cells
	Glypicans can function as coreceptors for multiple signaling molecules known for regulating cell growth, motility, and differentiation. Some members of the glypican family, including glypican 2 (GPC2) and glypican 3 (GPC3), are expressed in childhood cancers and liver cancers, respectively. Antibody-based therapies targeting glypicans are being investigated in preclinical and clinical studies, with the goal of treating solid tumors that do not respond to standard therapies.
TMPK-00592	Latexin Protein, Human, Recombinant (His) ECI,TCI,LXN,MUM	Human	E. coli
	Latexin, the endogenous protein inhibitor of the A/B subfamily of metallocarboxypeptidases, is expressed in small nociceptive neurons in sensory ganglia and in a subset of neurons in the telencephalon. Recently, the latexin (Lxn) gene was identified as a potential tumor suppressor in several types of solid tumors and lymphoma, and Lxn expression was found to be absent or downregulated in leukemic cells.
TMPJ-01207	UPP1 Protein, Human, Recombinant (His) UPP1,Uridine Phosphorylase 1,UPP1 Protein	Human	E. coli
	Uridinephosphorylase 1 (UPP1) is a member of the family of pentosyltransferase. UPP1 catalyses the reversible phosphorolysis of uridine to uracil. The expression levels and the enzymatic activity of UPP1 are higher in human solid tumors than in adjacent normal tissues. The high level of UPP1 expression in some tumors makes it a potential prognosticfactor for some cancers, such as oral squamous cell carcinoma. UPP1 is important for the homeostatic regulation of intracellular and plasma uridine c...
TMPY-04118	Livin/BIRC7 Protein, Human, Recombinant (His) MLIAP,baculoviral IAP repeat containing 7,RNF50,KIAP,ML-IAP,...	Human	E. coli
	BIRC7, a new member of inhibitor of the apoptosis protein family, is expressed in fetal tissues and most solid tumors in humans. BIRC7/livin expression is a novel prognostic marker in adult acute leukemia. Livin/BIRC7 is a member of the inhibitors of apoptosis proteins family, which are involved in tumor development through the inhibition of caspases. Livin/BIRC7 is specifically over-expressed in ACC, suggesting that it might be involved in adrenocortical tumorigenesis and represent a new molecu...
TMPY-04936	BCL2A1 Protein, Human, Recombinant (His) BFL1,ACC1,ACC-2,GRS,ACC-1,HBPA1,BCL2 related protein A1,BCL2...	Human	E. coli
	B-cell lymphoma 2-related protein A1 (BCL2A1) is a member of the BCL-2 family of anti-apoptotic proteins that confers resistance to treatment with anti-cancer drugs. Immunohistochemical expression of Wnt11 and BCL2A1 in complete moles and normal villi. Bcl2 family proteins control mitochondrial apoptosis and its members exert critical cell type and differentiation stage-specific functions, acting as barriers against autoimmunity or transformation. Anti-apoptotic Bcl2a1/Bfl1/A1 is frequently der...
TMPY-01583	ALDH1A1 Protein, Human, Recombinant (His) ALDH11,ALDC,PUMB1,ALDH-E1,HEL-S-53e,HEL-9,aldehyde dehydroge...	Human	E. coli
	Aldehyde dehydrogenase 1 family, member A1 (ALDH1A1), also known as Aldehyde dehydrogenase 1 (ALDH1), or Retinaldehyde Dehydrogenase 1 (RALDH1), is an enzyme that is expressed at high levels in stem cells and that has been suggested to regulate stem cell function. The retinaldehyde dehydrogenase (RALDH) subfamily of ALDHs, composed of ALDH1A1, ALDH1A2, ALDH1A3, and ALDH8A1, regulate development by catalyzing retinoic acid biosynthesis. The ALDH1A1 protein belongs to the aldehyde dehydrogenases f...
TMPY-00920	SFRP2 Protein, Mouse, Recombinant (His) secreted frizzled-related protein 2,AI851596,Sdf5	Mouse	HEK293 Cells
	The Secreted frizzled-related protein (SFRP) family consists of five secreted glycoproteins in humans (SFRP1~5) that act as extracellular signaling ligands. Each SFRP is approximately 3 amino acids in length and contains a cysteine-rich domain (CRD) that shares 3-5% sequence homology with the CRD of Frizzled (Fz) receptors, a putative signal sequence, and a conserved hydrophilic carboxy-terminal domain. SFRPs are able to bind Wnt proteins and Fz receptors in the extracellular compartment. The in...

重组蛋白

CCL5 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00008

Species: Mouse

Expression System: HEK293 Cells

CCL5 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00009

Species: Human

Expression System: E. coli

Glypican 2/GPC2 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01081

Species: Mouse

Expression System: HEK293 Cells

Latexin Protein, Human, Recombinant (His)

Cat.No: TMPK-00592

Species: Human

Expression System: E. coli

UPP1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01207

Species: Human

Expression System: E. coli

Livin/BIRC7 Protein, Human, Recombinant (His)

Cat.No: TMPY-04118

Species: Human

Expression System: E. coli

BCL2A1 Protein, Human, Recombinant (His)

Cat.No: TMPY-04936

Species: Human

Expression System: E. coli

ALDH1A1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01583

Species: Human

Expression System: E. coli

SFRP2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00920

Species: Mouse

Expression System: HEK293 Cells

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