149
51
7
1
113
4
Cat. No. | Product Name | ||
---|---|---|---|
L7810 | 高溶解性多官能团片段化合物库 | 1159 compounds | |
高溶解性多官能团片段库包含1159 种片段分子 | |||
L9410 | 共价抑制剂库 | 1920 compounds | |
1920 种小分子的独特集合,包含已发现的共价抑制剂以及包含某些共价反应基团常见弹头的分子,如氯乙酰基,2-氯丙酰基,丙烯酰基,1-丙-2-炔基,1-丁-2-炔基,酮羰基,二硫键等,可以用于共价抑制剂药物研发; | |||
L4000 | 经典已知活性库 | 14439 compounds | |
14439 个已知活性化合物的集合,可用于高通量筛选、高内涵筛选、细胞诱导和靶点确认; | |||
L6000 | 高通量筛选天然产物库 | 4533 compounds | |
4533 种天然产物的独特集合,是药物开发、药理研究、干细胞分化、指纹图谱研究、质量研究等领域的有力工具,可用于HTS 和HCS; | |||
L7600 | 趋化因子抑制剂库 | 59 compounds | |
59 种趋化因子或其受体抑制剂的独特集合,可用于高通量筛选和高内涵筛选; | |||
L2560 | 代谢化合物库 | 2320 compounds | |
2320 种代谢途径相关的化合物,可用于高通量和高内涵筛选。 | |||
L2550 | 谷氨酰胺代谢化合物库 | 565 compounds | |
565 种谷氨酰胺代谢相关的分子,可以用于高通量和高内涵筛选; |
Cat. No. | Product Name | Form | Specificity Of Inhibition |
---|---|---|---|
C0050 |
BCA Protein Quantification Kit
BCA蛋白浓度测定试剂盒 |
Solution in bottle |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T15598 |
Isosulfan blue
|
Others | Others |
Isosulfan blue 是用于淋巴管造影中淋巴管识别的蓝色染料,可用于乳腺癌前哨淋巴结活检,但其在乳腺癌手术中有发生过敏反应的可能性。 | |||
T50096 |
Neramexane HCl
1,3,3,5,5-pentamethylcyclohexan-1-amine HCl |
Others | Others |
1,3,3,5,5-pentamethylcyclohexan-1-amine hydrochloride,又称PAC,是一种环胺,通常用作不对称合成中的手性助剂,包括Diels-Alder 反应、羟醛反应和Michael 加成。 | |||
T19936 |
Xantphos
|
Others | Others |
Xantphos 是 Buchwald, Suzuki 等偶联反应中的配体,是可用于催化反应的金属螯合配体。 | |||
T21221 |
Meldrum's acid
丙二酸环(亚)异丙酯,Isopropylidene malonate,AI3-39039 |
Antibacterial | Microbiology/Virology |
Meldrum's acid (Isopropylidene malonate) 是一种用于除臭剂的抗菌剂。 基于 Meldrum's acid 多组分反应是制备新型聚合物的潜在工具。 | |||
T67732 |
Potassium trimethylsilanolate
Trimethylsiloxypotassium |
Others | Others |
Potassium trimethylsilanolate 是一种催化剂。Potassium trimethylsilanolate 通过(TMSOK)通过硼酸途径促进 Suzuki Miyaura 反应。 | |||
T19245 |
Cobalt phthalocyanine
Cobaltous phthalocyanine,酞菁钴,Phthalocyanine cobalt complex,Cobalt(II) phthalocyanine |
Others | Others |
Cobalt phthalocyanine (Phthalocyanine cobalt complex) 是氧化还原反应的催化剂,已经成功催化醛和酮从醛肟和酮肟中的有氧再生。 | |||
TP1399 |
Fmoc-N-Me-Leu-OH
|
Others | Others |
Fmoc-N-Me-Leu-OH 是 N-Fmoc-N-甲基氨基酸的一种,能够用于肽偶联反应。 | |||
T0663 |
2-Bromo-6-methoxynaphthalene
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
2-Bromo-6-methoxynaphthalene 用于通过 Heck 反应合成 nabumetone [4-(6-methoxy-2-naphthalenyl)-2-butanone]。 | |||
T15069 |
DBCO-PEG4-Biotin
ADIBO-NH-PEG2-Biotin |
Others | Others |
DBCO-PEG4-Biotin (ADIBO-NH-PEG2-Biotin) 是一种 azadibenzocyclooctyne-biotin 衍生物,含有生物素基团和 4 个 PEG。DBCO-PEG4-Biotin 是一种用途广泛的生物素酰化试剂,能通过无铜催化烷基叠氮化反应 (SPAAC) 将生物素的一部分引入叠氮标记的生物分子中。 | |||
T38155 |
N-Acetyl-D-cysteine
|
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
N-Acetyl-D-cysteine 具有抗氧化活性,机制是通过与巯基反应清除ROS。N-Acetyl-D-cysteine 不能进入谷胱甘肽代谢途径。 | |||
T3545 |
RG13022
RG 13022,Tyrphostin RG13022 |
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
RG13022 (Tyrphostin RG13022) 是一种酪氨酸激酶抑制剂,抑制EGF 受体自身磷酸化的IC50值为4 μM。 | |||
T6098 |
Cabotegravir
GSK744,GSK-1265744,卡博特韦,S/GSK1265744 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Cabotegravir (S/GSK1265744) 是一种HIV 整合酶抑制剂,可研究艾滋病。它抑制OAT1 和OAT3,IC50值为 0.81 和0.41 μM。 | |||
TP1437 |
Fmoc-N-Me-Ala-OH
|
Others | Others |
Fmoc-N-Me-Ala-OH 是一种可用于肽偶联反应的 N-Fmoc-N-甲基氨基酸。 | |||
T9264 |
ECBN HCL
1-[(4R,5R)-4,5-Dihydroxy-L-ornithine]echinocandin B hydrochloride (1:1) |
Others | Others |
ECBN HCL (A-30912A nucleus hydrochloride) 是一种 Echinocandin B 脱酰酶催化反应的产物。 | |||
T124635 |
Cyclo(L-Pro-L-Ile)
|
||
Cyclo(L-Pro-L-Ile) 是一种来自苏云金芽孢杆菌双酮哌嗪,可诱发中度超敏反应,可用于研究松树枯萎病。 | |||
T19030 |
NBD-Cl
4-氯-7-硝基苯并-2-氧杂-1,3-二唑,NBD chloride |
Others | Others |
NBD-Cl (NBD chloride) 是非荧光剂,能够与巯基或氨基反应,产生高度荧光。 | |||
T6336 |
Amonafide
NSC308847,AS1413,氨萘非特,Nafidimide,AS1413,Quinamed |
Topoisomerase | DNA Damage/DNA Repair |
Amonafide (NSC-308847,AS1413) 是一种拓扑异构酶 II 的抑制剂和 DNA 的嵌入剂,通过拓扑异构酶 II 介导的反应产生蛋白质相关的 DNA 链断裂 | |||
T36688 |
Deoxyguanosine triphosphate trisodium salt
Deoxyguanosine 5-triphosphate,2'-Deoxyguanosine-5'-triphosphate trisodium salt,dGTP trisodium salt |
Nucleoside Antimetabolite/Analog | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Deoxyguanosine triphosphate trisodium salt (2'-Deoxyguanosine-5'-triphosphate trisodium salt) 是细胞中用于 DNA 合成的核苷酸前体,可用于逆转录聚合酶链反应 (RT-PCR) 中以进行 DNA 扩增。 | |||
T10009 |
JAK3-IN-7
|
JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
JAK3-IN-7 是一种有效的选择性 JAK3 抑制剂(IC50<0.01 μM),可用于治疗器官移植中的排斥反应、器官移植后的移植物抗宿主反应、自身免疫性疾病、过敏性疾病和慢性骨髓增生性疾病。 | |||
T0694 |
Pranlukast
普鲁司特,ONO-1078,普仑司特 |
Leukotriene Receptor; IL Receptor; Others; TNF; NF-κB; LTR | Apoptosis; GPCR/G Protein; Immunology/Inflammation; NF-κB; Others |
Pranlukast (ONO-1078) 是一种半胱氨酰白三烯受体 1 拮抗剂,可拮抗或减少支气管痉挛,用于哮喘研究。 | |||
T1546 |
Nitazoxanide
NSC 697855,硝唑尼特 |
Others; Influenza Virus; Parasite; Autophagy | Autophagy; Microbiology/Virology; Others |
Nitazoxanide (NSC-697855) 是一种广谱驱虫剂,对感染动物和人类的各种蠕虫、原生动物和肠道细菌都具有作用活性。 它在无菌培养中抑制Giardia lamblia 滋养体增殖,IC50为 2.4 μM。它可研究寄生虫性胃肠炎,具有抗病毒特性。 | |||
T1366 |
3-Pyridylacetic acid hydrochloride
|
DPP-4 | Proteases/Proteasome |
3-Pyridylacetic acid hydrochloride (3-PAA-HCl)尼克酸的高同系物,是尼古丁(和其它烟草生物碱)的分解产物,还可与胺、醇和羧酸等反应,也可在反应中作为酸催化剂。 | |||
T72028 |
2-Quinolinecarboxaldehyde
Quinoline-2-carbaldehyde |
Others | Others |
2-Quinolinecarboxaldehyde (Quinoline-2-carbaldehyde) 是一个小的刚性分子,是在亨利反应和随后的消除中的一个化合物。2-Quinolinecarboxaldehyde 抑制 AChE,IC50 为 13.48 μM。 | |||
T16251 |
N-Succinimidyl-S-acetylthioacetate
SATA,N-丁二酸,S-乙酰基巯基乙二醇酯 |
Others | Others |
N-Succinimidyl-S-acetylthioacetate (SATA) 是蛋白质修饰剂,它能够以受保护的形式将巯基添加到蛋白质和其他含胺分子中。 | |||
T5095 |
Oxazolone
4-乙氧基亚甲基-2-苯基-2-唑啉-5-酮,4-Ethoxymethylene-2-phenyl-2-oxazolin-5-one |
Others | Others |
Oxazolone 已被用作半抗原化剂,可在成年斑马鱼肠道组织中诱导炎症反应,并可用作两种形式的炎症性肠病(如克罗恩病和溃疡性结肠炎)的基因表达研究模型。 | |||
T4382 |
Proguanil hydrochloride
Paludrine hydrochloride,盐酸氯胍,Chlorguanide hydrochloride,Chloroquanil |
Others; Dehydrogenase; DNA/RNA Synthesis; Antifolate; Parasite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; Others |
Proguanil hydrochloride (Chloroquanil) 是一种双胍类抗疟疾剂,在体内代谢形成环胍。它还是一种二氢叶酸还原酶抑制剂。 | |||
T1992 |
Mertansine
DM1,Maytansinoid DM1 |
Microtubule Associated; ADC Cytotoxin | Antibody-drug Conjugate/ADC Related; Cytoskeletal Signaling |
Mertansine (DM1) 是一种微管蛋白抑制剂,也是一种抗体可缀合的美登木素生物碱。它通过连接体连接到单克隆抗体上,形成抗体偶联药物。 | |||
T15447 |
Guacetisal
|
Others | Others |
Guacetisal 是从乙酰水杨酸与愈创木酚的酯化反应中提取的,可用于治疗慢性支气管炎的相关研究。 | |||
T1347 |
2-Benzothiazolamine
2-Aminobenzothiazole,2-氨基苯并噻唑 |
IL Receptor; Others | Immunology/Inflammation; Others |
2-Benzothiazolamine (2-ABT)是一种含氮杂环化合物,被用作合成多种药物的反应中间体。它可抑制细胞色素P450的活性,也在动物模型中显示出抗炎、抗惊厥和抗癌活性。 | |||
T12001 |
Menaquinone-7
Vitamin MK-7,维生素 K2(35),Vitamin K2-7,Vitamin K2(35) |
Others | Others |
Menaquinone-7 (Vitamin K2(35)) 是一种最早作为抗出血因子被发现的维生素K2家族成员。它是Gla-蛋白羧化反应中最具生物活性的辅因子,补充它也是激活Gla 基质蛋白并干预钙化性主动脉瓣狭窄(CAVS)进展的一种药理选择。 | |||
TP2497 |
Myristoyl Tetrapeptide-12 Acetate
醋酸肉蔻酰四胜肽-12,Myristoyl Tetrapeptide-12 Acetate(959610-24-3 Free base) |
Others | Others |
Myristoyl Tetrapeptide-12 Acetate (Myristoyl Tetrapeptide-12 Acetate (959610-24-3 Free base)) 是肉豆蔻酸和 Tetrapeptide-12 的反应产物,是一种刺激头发和睫毛生长并增强睫毛和/或眉毛外观的肽。 Myristoyl tetrapeptide-12 可以增加角质形成细胞的增殖,改善外观、紧致弹性和皮肤厚度。 | |||
T1488 |
Procarbazine hydrochloride
NSC-77213 HCl,盐酸甲基苄肼,Procarbazine HCl |
DNA Alkylator/Crosslinker; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Procarbazine hydrochloride (NSC-77213 HCl) 是一种烷化剂,是甲基肼衍生物的盐酸盐,具有抗肿瘤和诱变活性。 | |||
T22739 |
DMPO
5,5-二甲基-1-吡咯啉-N-氧化物,5,5-Dimethyl-1-pyrroline N-oxide |
Others | Others |
DMPO (5,5-Dimethyl-1-pyrroline N-oxide) 是一种亲水自旋诱捕剂,具有细胞渗透性。DMPO 可用于超氧化物检测,可检测超氧阴离子和羟自由基。 | |||
T5331 |
KKL-35
|
Antibacterial | Microbiology/Virology |
KKL-35 是一种具有广谱抗生素活性的反式翻译抑制剂,IC50值为 0.9 µM。 | |||
T3979 |
Emedastine
LY188695,依美斯汀,Emadine |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Emedastine (LY188695) 是一种可口服的,选择性和高亲和力的组胺 H1受体拮抗剂,Ki 值为 1.3 nM。它是苯并咪唑衍生物,可用于过敏性鼻炎、过敏性皮肤疾病和过敏性结膜炎的研究。 | |||
T1577 |
Midodrine hydrochloride
Pro-Amatine,盐酸米多君 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Midodrine hydrochloride (Pro-Amatine) 通过去甘氨酸反应转化为其活性代谢物 desglymidodrine。Desglymidodrine 选择性地结合并激活小动脉和静脉血管系统的 α-1-肾上腺素能受体。这会导致平滑肌收缩并导致血压升高。 Desglymidodrine 在血脑屏障中的扩散很差,因此与对中枢神经系统的影响无关。Midodrine hydrochloride 是 midodrine 的盐酸盐形式,是一种直接作用的前药和拟交感神经药,具有抗低血压特性。 | |||
TP1573L |
CLIP 86-100 acetate(648881-58-7 free base)
|
Others | Others |
CLIP 86-100 acetate(648881-58-7 free base) 这是称为 CLIP 的 II 类相关不变链肽的氨基酸 86 至 100 片段。主要组织相容性复合物 II 类分子显示外源蛋白的肽片段,以触发免疫系统的防御反应。在将外源肽插入结合槽之前,去除一个占位肽 CLIP。这是通过分子 DM 实现的,它被证明可以增加 CLIP 肽与 II 类的解离速率。 | |||
T37190 |
L-Allylglycine
|
Dehydrogenase; GABA Receptor | Membrane transporter/Ion channel; Metabolism; Neuroscience |
L-Allylglycine 是 GABA 合成酶(谷氨酸脱羧酶)的有效抑制剂。 | |||
T31984 |
GNF-5326
|
Others | Others |
GNF-5326 can be used for radiolabeling GNF-1331 through a 3H-hydrogenation reaction. | |||
T20334 |
Furoin
NSC 18522,NSC18522,NSC-18522 |
Others | Others |
Furoin is an organic compound. It can be produced from furfural by a benzoin condensation reaction catalyzed by cyanide ions. | |||
T25733 |
Lincophenicol
|
Others | Others |
Lincophenicol is an Escherichia coli ribosomal peptidyltransferase-catalyzed puromycin reaction inhibitor. | |||
T19903 |
Alizarine Yellow R
C.I. 14030 |
||
Alizarine Yellow R is a yellow colored azo dye. Alizarine Yellow R made by the diazo coupling reaction. | |||
T31878 |
Fructose-arginine
Arginyl fructose,Fructose arginine,Arginyl-fructose,J1.147.777A |
Others | Others |
Fructose-arginine is a maillard reaction product. | |||
T34073 |
Pipratecol
|
Others | Others |
Pipratecol can affect platelet aggregation and the platelet release reaction. | |||
T12776L |
Real Thiol
|
Others | Others |
Real Thiol, a reversible reaction-based fluorescent probe, can quantitatively monitor the real-time glutathione dynamics in living cells. | |||
T75343 |
JOE
|
Others | Others |
JOE,作为一种荧光染料,主要应用于 DNA 测序、PCR 以及 LCR 扩增。其吸光度和发射波长分别为 525 nm 和 550 nm。 | |||
T26430 |
A 65282
A65282,A-65282 |
Others | Others |
A 65282 is an antibacterial isothiazoloquinolone and a potent inhibitor of the P4-unknotting reaction. It induces considerable DNA breakage mediated by calf thymus topoisomerase II. | |||
T24341 |
L 691816
L 691,816,L-691,816,L-691816,L691,816,L691816 |
Others | Others |
L 691816 is an effective inhibitor of the 5-LO reaction. | |||
T18897 |
5(6)-ROX
5(6)-Carboxy-X-rhodamine |
Others | Others |
5(6)-ROX, a nucleic acid fluorescent label, serves as a reference dye in real-time polymerase chain reaction (PCR) applications. | |||
T26429 |
A 65281
A65281,A-65281 |
Others | Others |
A 65281 is an antibacterial isothiazoloquinolone and a potent inhibitor of the P4-unknotting reaction. It induces considerable DNA breakage mediated by calf thymus topoisomerase II. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
Fr14207 |
(-)-Isopulegol
|
Others | Others |
(-)-Isopulegol 具有抗氧化和神经活性特性。它还具有由异胡薄荷醇诱导的胃保护作用,似乎至少部分由内源性前列腺素介导,K+ATP 通道开放和与 GSH 相关的抗氧化特性增加。 | |||
T8097 |
Methyl 3-aminopropanoate hydrochloride
β-Alanine methyl ester hydrochloride,3-氨基丙酸甲酯盐酸盐 |
Others | Others |
Methyl 3-aminopropanoate hydrochloride (β-Alanine methyl ester hydrochloride) 是由 Β-Alanine (I) 酯化得到。它可用于合成双齿吡啶酸配体。 | |||
T7997 |
β-D-Glucose pentaacetate
β-D-葡萄糖五乙酸酯,Penta-O-acetyl-β-D-glucopyranose,1,2,3,4,6-beta-D-葡萄糖五乙酸酯 |
Others | Others |
β-D-Glucose pentaacetate (Penta-O-acetyl-β-D-glucopyranose) 一种能够用于生化反应的物质。 | |||
TN3820 |
Demethoxydeacetoxypseudolaric acid B
|
Others | Others |
Demethoxydeacetoxypseudolaric acid B 是 pseudolaric acid C2 的一种代谢物。 | |||
T3244 |
2-Deoxy-2-sulfoamino-D-glucose sodium
氨基葡萄糖硫酸钠盐,N-Sulfo-D-glucosamine sodium salt,N-Sulfo-glucosamine sodium salt,GlcN-2S,2-Deoxy-2-sulfamino-D-glucopyranose |
Others; Endogenous Metabolite | Metabolism; Others |
2-Deoxy-2-sulfoamino-D-glucose sodium (GlcN-2S) 是内源性代谢产物的一种。 | |||
T4748 |
1,4-Dioxane-2,5-diol
Glycolaldehyde dimer,乙醇醛二聚体,Hydroxyacetaldehyde dimer,2,5-Dihydroxy-1,4-dioxane |
Others; Endogenous Metabolite | Metabolism; Others |
1,4-Dioxane-2,5-diol (Glycolaldehyde dimer) 是内源性代谢产物的一种。 | |||
T4738 |
Sodium 2-hydroxybutanoate
2-Hydroxybutyric acid sodium salt,2-羟基丁酸钠,DL-2-Hydroxybutyric Acid Sodium Salt,alpha-hydroxybutyrate,SODIUM 2-HYDROXYBUTYRATE |
Others; Endogenous Metabolite | Metabolism; Others |
Sodium 2-hydroxybutanoate (alpha-hydroxybutyrate) 是内源性代谢产物的一种。 | |||
TJS0851 |
Plantagoside
|
Others | Others |
Plantagoside 是α-mannosidase 的非竞争性特异性抑制剂(IC50:5 μM),分离自Plantago asiatica 种子中。 | |||
T4890 |
3-Nitro-L-tyrosine
3-Nitrotyrosine,3-硝基-L-酪氨酸 |
Endogenous Metabolite | Metabolism |
3-Nitro-L-tyrosine (3-Nitrotyrosine) 在系统自免疫原性条件下,能够作无氮自由基修饰蛋白的生物标记物。 | |||
T19081 |
1,3-Dithiane
1,3-Dithian,M-DITHIANE,1,3-Dithiacyclohexane,1,3-二噻烷 |
Anti-infection; Endogenous Metabolite; Antibacterial | Metabolism; Microbiology/Virology |
1,3-Dithiane (1,3-Dithian) 是一种受保护的甲醛阴离子等价物,可用作有用的标记合成子。它是在煮熟的牛肉提取物中发现的含硫美拉德反应产物 。 | |||
T4960 |
VASICINE
|
Anti-infection; AChR | Microbiology/Virology; Neuroscience |
Vasicine 是一种分离自Justicia adhatoda 中的喹唑啉类生物碱。它具有抗结核作用。 | |||
TN7244 |
Egg PG
Phosphatidylglycerols(egg) |
||
Egg PG(Phosphatidylglycerols(egg)) 是一种食物和生物组织的主要磷脂酰甘油之一,常存在于细菌和动物细胞的膜中,可作为 sPMCA,反应中的阴离子磷脂底物。 | |||
T3016 |
D-(+)-Melezitose hydrate
D-Melezitose,melicitose,Melezitose,松三糖 |
Others; Antibacterial | Microbiology/Virology; Others |
D-(+)-Melezitose hydrate (melicitose) 是由许多以植物汁液为食的昆虫通过酶反应产生的一种非还原性三糖,能鉴定吲哚阳性和吲哚阴性克雷伯菌属的临床分离株。 | |||
T37984 |
Fosfructose, sodium salt, hydrate (1:3:8)
D-Fructose-1,6-bisphosphate , sodium salt, hydrate (1:3:8) |
Others | Others |
D-Fructose-1,6-bisphosphate sodium salt hydrate 是碳水化合物代谢的中间体,包括糖酵解和糖异生。在糖酵解过程中,它是由磷酸果糖激酶磷酸化果糖-6-磷酸产生的。由果糖-1,6-二磷酸酶-1介导的逆反应是糖异生的限速步骤之一。同样的反应也发生在植物的叶绿体中,D-Fructose-1,6-bisphosphate sodium salt hydrate 作为还原性戊糖磷酸循环的一部分。由于癌细胞采用糖酵解作为代谢能量产生的主要来源,这一途径已成为癌症化疗的主要靶点。 | |||
T4883 |
Creatine
Methylguanidoacetic acid,肌酸 |
Endogenous Metabolite | Metabolism |
Creatine (Methylguanidoacetic acid) 是一种内源性氨基酸代谢物,在细胞能量中发挥重要作用,尤其是在肌肉和大脑中。 | |||
T5292 |
N-Acetyl-L-tyrosine
N-乙酰-L-酪氨酸,N-Acetyltyrosine,Ac-Tyr-OH |
Others; Endogenous Metabolite | Metabolism; Others |
N-Acetyl-L-tyrosine (Ac-Tyr-OH) 是一种来源于AA 乙酰酶作用下的酪氨酸,和芳香族氨基酸脱羧酶缺乏症以及酪氨酸血症有关,能够作为儿茶酚胺的前体,用于治疗神经递质。 | |||
T4721 |
β-Nicotinamide mononucleotide
NMN,β-NM,β烟酰胺单核苷酸,烟酰胺单核苷酸 |
Others; Endogenous Metabolite | Metabolism; Others |
β-nicotinamide mononucleotide 是烟酰胺磷酸核糖转移酶 (NAMPT) 反应的产物。β-nicotinamide mononucleotide的作用包括其在细胞生化功能、心脏保护、糖尿病、肥胖相关并发症和阿尔茨海默病中的作用。 | |||
T3818 |
Fraxinol
|
Others; P450 | Metabolism; Others |
Fraxinol 是一种分离自半边莲中的化合物。 | |||
T4798 |
N-Acetyl-L-leucine
|
Others; Endogenous Metabolite | Metabolism; Others |
N-Acetyl-L-leucine 是内源性代谢产物的一种。 | |||
T4915 |
β-Glycerophosphate disodium salt hydrate
|
Phosphatase; Endogenous Metabolite | Metabolism |
β-Glycerophosphate disodium salt hydrate 是一种磷酸酶抑制剂,是内源性代谢产物的一种。 | |||
T3737 |
3-(2,4-Dihydroxyphenyl)propanoic acid
3-(2,4-二羟基苯)丙酸,Hydroumbellic acid,2,4-Dihydroxyhydrocinnamic acid |
Tyrosinase | Proteases/Proteasome |
3-(2,4-Dihydroxyphenyl)propanoic acid (Hydroumbellic acid) 是竞争性酪氨酸酶 (tyrosinase) 抑制剂,可抑制 L-Tyrosine 和 DL-DOPA,IC50和 Ki 分别为 3.02 μM 和 11.5 μM。 | |||
T2A2428 |
2-Hydroxy-4-methoxybenzoic acid
2-Hydroxy-p-anisic Acid,4-Methoxysalicylic acid,对甲氧基水杨酸,2-羟基-4-甲氧基苯甲酸 |
Others | Others |
2-Hydroxy-4-methoxybenzoic acid (2-Hydroxy-p-anisic Acid) 是一种甲氧基苯甲酸的衍生物,它是一种潜在的生物标志物。 | |||
T4712 |
H-D-cis-Hyp-OH
顺式-4-羟基-D-脯氨酸,D-allo-Hydroxyproline,cis-4-Hydroxy-D-proline |
Others; Endogenous Metabolite | Metabolism; Others |
H-D-cis-Hyp-OH (D-allo-Hydroxyproline) 是一种合成构象受限的 PNA 腺嘌呤单体的前体,能够用于 D-丙氨酸脱氢酶的特异性和动力学的研究。 | |||
T1362 |
Hypoxanthine
次黄嘌呤,6-羟基嘌呤,6-Hydroxypurine,Purin-6-ol,Sarcine,Sarkin |
Others; Endogenous Metabolite | Metabolism; Others |
Hypoxanthine (Purin-6-ol),也被称为 purine-6-ol 或 Hyp,是一种天然存在的嘌呤衍生物,是腺苷代谢和核苷酸补救途径形成核酸的反应中间体。在正常情况下,Hypoxanthine 很容易转化为尿酸。Hypoxanthine 首先被氧化为黄嘌呤,黄嘌呤再被黄嘌呤氧化酶氧化为尿酸。 | |||
T4862 |
Oxaloacetic acid
|
Endogenous Metabolite | Metabolism |
Oxaloacetic acid 是一种代谢中间体,涉及多种途径,如葡萄糖异生、柠檬酸循环、乙醛酸循环、尿素循环、氨基酸合成和脂肪酸合成。 | |||
T5245 |
N-Isovaleroylglycine
N-异戊酰氨基乙酸,Isovaleroylglycine,N-Isovalerylglycine |
Others; Endogenous Metabolite | Metabolism; Others |
N-Isovaleroylglycine (Isovaleroylglycine) 是酰基甘氨酸,能够作为体重提高和肥胖的生物标记物。 | |||
T4909 |
N-Acetyl-DL-methionine
N-乙酰-DL-蛋氨酸,N-乙酰-DL-甲硫氨酸 |
Others; Endogenous Metabolite | Metabolism; Others |
N-Acetyl-DL-methionine 是内源性代谢产物的一种。 | |||
T1311 |
4-aminobenzoic acid
PABA,Vitamin H1,Vitamin Bx,para-Aminobenzoic acid,对氨基苯甲酸 |
Endogenous Metabolite | Metabolism |
4-aminobenzoic acid 是一种具有紫外线吸收和抗纤维化特性的有机酸。当暴露在光线下时,4-aminobenzoic acid 吸收紫外线并通过光化学反应释放多余的能量,这可能会对DNA造成损害。4-aminobenzoic acid 还可以增加组织水平的摄氧量,并可能增强单胺氧化酶(MAO)活性以促进血清素的降解,过量可能导致纤维化变化。 | |||
T5089 |
5-Aminovaleric acid
|
Others; Endogenous Metabolite | Metabolism; Others |
5-Aminovaleric acid 被认为是 GABA 的亚甲基同系物,是GABA 的弱激动剂。它是赖氨酸降解产物。 它既能够内源性产生,也能够通过赖氨酸的细菌分解代谢产生。 | |||
T37974 |
(S)-Coriolic acid
13(S)-HODE |
Lipoxygenase; Mitochondrial Metabolism; PPAR | DNA Damage/DNA Repair; Metabolism |
(S)-Coriolic acid (13(S)-HODE) 是一种重要的细胞内信号剂,是亚油酸与植物和哺乳动物脂氧合酶反应生成的,在各种生物系统中参与细胞增殖和分化。(S)-Coriolic acid 在 1 μM 左右时,它能抑制肿瘤细胞与血管内皮的粘附,能下调 IRGpIIb/IIIa 受体的表达。(S)-Coriolic acid 是15-脂氧合酶 (15-LOX) 代谢产物,常作为内源性配体激活 PPARγ。(S)-Coriolic acid 诱导线粒体功能障碍 和气道上皮损伤。 | |||
T8274 |
3-Methyl-L-histidine
|
Endogenous Metabolite | Metabolism |
3-Methyl-L-histidine 是一种肉类尤其是鸡肉摄入和大豆制品摄入的生物标记。 | |||
T4716 |
Pyrrole-2-carboxylic acid
吡咯-2-羧酸,2-Pyrrolecarboxylic acid,Minaline |
Endogenous Metabolite | Metabolism |
Pyrrole-2-carboxylic acid (Minaline) 是一种天然生物碱类,从海洋细菌Pelomonas puraquaesp. Nov 中分离得到。 | |||
TN1163 |
2'-Hydroxychalcone
|
Others | Others |
2'-Hydroxychalcone 是一种药物合成中间体,可用于合成黄酮类化合物。负载在纳米乳液中的2'-Hydroxychalcone 在Danio rerio 模型对副球孢子菌显示出杀真菌活性。2'-Hydroxychalcone 通过负载脂质的Hepg2细胞中的氧化应激诱导细胞毒性。2'-Hydroxychalcone 抑制通过逆转录聚合酶链反应确定的肿瘤坏死因子-α诱导ICAM-1,VCAM-1和E-选择素的稳态转录水平,因此可能会干扰其基因的转录。 | |||
T4858 |
4-Hydroxyphenylpyruvic acid
4-羟苯基丙酮酸,4-Hydroxyphenylpyruvic acid |
Endogenous Metabolite | Metabolism |
4-Hydroxyphenylpyruvic acid 是一种苯丙氨酸代谢的中间产物,是一种酶抑制剂。 | |||
T4826 |
L-Histidine monohydrochloride monohydrat
|
Others; Endogenous Metabolite | Metabolism; Others |
L-Histidine monohydrochloride monohydrat 是一种 α-氨基酸。 L-异构体是 22 种蛋白质氨基酸之一,即蛋白质的组成部分。 | |||
T20270 |
N-Butyl stearate
NSC4820,NSC 4820,NSC-4820 |
||
Butyl stearate enteric-coated tablets cause a reaction in intestinal enzymes. | |||
TMA0955 |
Thunberginol C
|
Antifection | Microbiology/Virology |
Thunberginol C exhibits antimicrobial activity against oral bacteria. It shows antiallergic activity in the in vitro bioassay using the Schults-Dale reaction in sensitized guinea pig bronchial muscle. | |||
T15350 |
Fructosyl-lysine
Fructoselysine,果糖-赖氨酸 |
Others | Others |
Fructosyl-lysine is the precursor to glucosepane. Fructosyl-lysine is a lysine–arginine protein cross-link that can be an indicator in diabetes detection. Fructosyl-lysine is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. | |||
TN6565 |
Maculosidin
|
||
Maculosidine affect the PS I electron acceptors on leaf discs, it can inhibit ATP synthesis, basal, phosphorylating and uncoupled electron transport acting as Hill reaction inhibitors on spinach chloroplasts. | |||
TN2155 |
Rhodiocyanoside A
|
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Rhodiocyanoside A has antiallergic activity, it exhibits inhibitory activity on the histamine release from rat peritoneal exudate cells sensitized with anti-DNP IgE and inhibits the PCA reaction in rats. | |||
TN3699 |
Corchoionoside C
|
Antifection; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience |
Corchoionoside C has antioxidant activity, shows strong scavenging activities on DPPH radical, it also shows weak antifungal activity. Corchoionosides A, B, and C inhibit the histamine release from rat peritoneal exudate cells induced by antigen-antibody reaction. | |||
T13753 |
(±)-Licarin A
(±)-trans-Dehydrodiisoeugenol |
Others | Others |
(±)-Licarin A ((±)-trans-Dehydrodiisoeugenol) is a dihydrobenzofuran neolignan, the resultant of an oxidative coupling reaction of isoeugenol and horseradish peroxidase (HRP) enzyme. (±)-Licarin A shows 100% parasites mortality at 200 μM. | |||
T81735 |
Mycestericin C
|
||
Mycestericin C, 分离自 Mycelia sterilia ATCC 20349 的培养液, 能在小鼠同种异体混合淋巴细胞反应中抑制淋巴细胞的增殖。 | |||
TN7291 |
2-Deoxyribose 5-phosphate disodium
|
Others | Others |
2-Deoxyribose 5-phosphate disodium 是一种2-deoxyribose-5-phosphate aldolase (DERA) 的底物,该酶为I类醛缩酶,负责催化可逆醛缩反应,且在过程中不需要任何辅助因子。 | |||
TN6663 |
trans-4-(Trifluoromethyl)cinnamic acid
|
||
trans-4-(Trifluoromethyl)cinnamic acid 是一种光敏化合物。它被用作合成各种化合物的试剂,如杂环化合物和药物。它也被用作有机反应的催化剂,例如赫克反应和铃木-宫浦反应。它还被用作生物学研究中的荧光探针,以检测和监测各种生物分子。 | |||
T82926 |
Bacteriopheophytin
|
||
Bacteriopheophytin是细菌脱镁叶绿素的一种,由细菌叶绿素去除镁中心并由两个氢原子取代形成。在紫色细菌的反应中心(RC)中,它作为电子受体参与电子转移过程。 | |||
T81428 |
Polypectate sodium
pectate sodium |
||
Polypectate sodium作为细胞壁多糖(果胶)的关键组分,充当碳源及多聚半乳糖醛酸酶诱导剂。此外,Polypectate sodium适用于评估链霉菌属果胶酸裂解酶的碱性活性与稳定性,同时用于黄腐藻多聚半乳糖醛酸酶生产及反应条件的优化研究。 | |||
T82248 |
Gymnoside I
|
||
Gymnoside I(化合物1)是糖苷氧基苄基2-异丁基苹果酸,其在小鼠被动皮肤过敏反应(PCA)实验中展现出抗过敏效能。该化合物有望在哮喘、神经衰弱和慢性肝炎治疗研究中应用。 | |||
TN5164 |
trans-Hinokiresinol
|
IL Receptor; TNF; NOS; LTR | Apoptosis; Immunology/Inflammation |
Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphylaxis reaction. Hinokiresinol (trans-hinokiresinol) and nyasol (cis-hinokiresinol) are estrogen | |||
T35415 |
α-D-Glucose-1,6-bisphosphate (potassium salt hydrate)
|
Others | Others |
α-D-Glucose-1,6-bisphosphate is abis-phosphorylated derivative of α-D-glucose that has roles in carbohydrate metabolism.1It is the product of the reaction of glucose-1- or 6-phosphate with glucose-1,6-bisphosphate synthase (PGM2LI) in the conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate.2It is also a cofactor for the bacterial enzyme phosphopentomutase.3,4α-D-Glucose-1,6-bisphosphate has been used in the study of carbohydrate metabolism. 1.Beitner, R.Regulation of carbohydrate metabol... | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-01220 |
DDA1 Protein, Human, Recombinant (His)
Placenta cross-immune reaction antigen 1,DET1- and ... |
Human | E. coli |
Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex. DDA1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 17.7 kDa and the accession number is Q9BW61. | |||
TMPY-02292 |
IGSF11 Protein, Human, Recombinant (His)
CT119,immunoglobulin superfamily, member 11,BT-IgSF,Igsf13,C... |
Human | HEK293 Cells |
Immunoglobulin superfamily member 11(IGSF11) is expressed on the plasma membrane in the testis and brain. These IGSF proteins undergo final modifications during capacitation and/or the acrosome reaction. IGSF proteins share significant homology with endothelial cell-selective adhesion molecule and coxsackievirus and adenovirus receptor, which mediates cell attachment and homotypic intercellular interactions. In clinical, the IGSF11 has been reported to overexpressed in colorectal cancers and hep... | |||
TMPY-03118 |
ORM2 Protein, Human, Recombinant (His)
AGP-B',ORM2,orosomucoid 2,AGP-B,AGP2 |
Human | HEK293 Cells |
ORM2 belongs to the calycin superfamily, lipocalin family. Lipocalins share limited regions of sequence homology and a common tertiary structure architecture. They transport small hydrophobic molecules such as steroids, bilins, retinoids, and lipids. Lipocalins can be found in gram-negative bacteria, vertebrate cells, and invertebrate cells, and plants. They are associated with many biological processes. ORM2 functions as a transport protein in the bloodstream. It is expressed by the liver and s... | |||
TMPY-02801 |
PHGDH Protein, Human, Recombinant (His)
phosphoglycerate dehydrogenase,HEL-S-113,3PGDH,NLS1,PHGDHD,P... |
Human | E. coli |
PHGDH is a member of the D-isomer specific 2-hydroxyacid dehydrogenase family. This new family consists of D-isomer-stereospecific enzymes. The conserved residues in this family appear to be the residues involved in the substrate binding and the catalytic reaction, and thus to be targets for site-directed mutagenesis. A number of NAD-dependent 2-hydroxyacid dehydrogenases which seem to be specific for the D-isomer of their substrate have been shown to be functionally and structurally related. PH... | |||
TMPY-01104 |
Coagulation factor XI/F11 Protein, Human, Recombinant (His)
coagulation factor 11,coagulation factor XI,FXI |
Human | HEK293 Cells |
Factor XI (plasma thromboplastin antecedent) is a plasma glycoprotein, and a zymogen acting as a serine protease which participates in blood coagulation as a catalyst in the conversion of factor IX to factor IXa in the presence of calcium ions. It is an unusual dimeric protease, with structural features that distinguish it from vitamin K-dependent coagulation proteases. The factor XI is synthesized in the liver as a single polypeptide chain with a molecular weight estimated between 125 ~160 kDa ... | |||
TMPH-03084 |
CrtX Protein, Pantoea ananas, Recombinant (E. coli, His & Myc)
Zeaxanthin glucosyltransferase,crtX,ugt101 |
Pantoea ananas | E. coli |
Catalyzes the glycosylation reaction which converts zeaxanthin to zeaxanthin bis(beta-D-glucoside). The reaction proceeds in two steps with the monoglucoside as an intermediate. CrtX Protein, Pantoea ananas, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 54.7 kDa and the accession number is P21686. | |||
TMPH-03454 |
GPM1 Protein, S. cerevisiae, Recombinant (His)
BPG-dependent PGAM 1,Phosphoglycerate mutase 1,GPM1,MPGM 1,P... |
Saccharomyces cerevisiae | P. pastoris (Yeast) |
Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also Catalyzes the reaction of EC 5.4.2.4 (synthase), but with a reduced activity. GPM1 Protein, S. cerevisiae, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 29.5 kDa and the accession number is P00950. | |||
TMPH-00663 |
APT Protein, E. coli O139:H28, Recombinant (His & Myc)
APRT,apt,Adenine phosphoribosyltransferase |
E. coli | E. coli |
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | |||
TMPJ-01057 |
PSP Protein, Human, Recombinant (His)
PSPH,L-3-Phosphoserine Phosphatase,PSPase,Phosphoserine Phos... |
Human | E. coli |
Phosphoserine phosphatase (PSP) is an enzyme that belongs to the serB family. PSPH catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates. Deficiency of this protein is thought to be linked to Williams syndrome. A disorder that results in pre- and postnatal growth retardation, moderate psychomotor retardation and facial fea... | |||
TMPH-03083 |
CrtX Protein, Pantoea ananas, Recombinant (His & Myc)
Zeaxanthin glucosyltransferase,ugt101,crtX |
Pantoea ananas | Baculovirus Insect Cells |
Catalyzes the glycosylation reaction which converts zeaxanthin to zeaxanthin bis(beta-D-glucoside). The reaction proceeds in two steps with the monoglucoside as an intermediate. CrtX Protein, Pantoea ananas, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 51.1 kDa and the accession number is P21686. | |||
TMPH-00683 |
TMAO reductase 1 Protein, E. coli O157:H7, Recombinant (His & Myc)
Trimethylamine-N-oxide reductase 1,torA |
E. coli | E. coli |
Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions. | |||
TMPK-00101 |
IL-6 Protein, Cynomolgus, Recombinant (His)
CDF,BSF-2,白介素,IL6,HGF,白细胞介素,Interleukin-6,HSF,MGI-2A,IFN-β-2... |
Cynomolgus | HEK293 Cells |
IL-6 (Interleukin-6) is a pleiotropic cytokine that acts in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression.Interleukin 6 has been shown to interact with interleukin-6 receptor and glycoprotein. | |||
TMPH-03108 |
GPX5 Protein, Pig, Recombinant (E. coli, His & Myc)
GPX5,Glutathione peroxidase 5,Epididymis-specific glutathion... |
Sus scrofa (Pig) | E. coli |
May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids. Since the purified porcine enzyme has very little activity towards hydrogen peroxide or organic hydroperoxides the protective effect is not likely to be exerted by its enzymatic activity. Instead, may protect sperm from premature acrosome reaction in the epididymis by binding to lipid peroxides, which might otherwise interact with phospholipase A2 and induce the acrosome reaction. GPX... | |||
TMPH-01603 |
Lanosterol synthase/LSS Protein, Human, Recombinant (His)
Lanosterol synthase,LSS,2,3-epoxysqualene--lanosterol cyclas... |
Human | E. coli |
Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency. | |||
TMPH-00608 |
Dihydrofolate reductase Protein, E. coli, Recombinant (His)
Dihydrofolate reductase,folA,tmrA |
E. coli | E. coli |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | |||
TMPH-01224 |
Dihydrofolate reductase Protein, Human, Recombinant (His)
DHFR,Dihydrofolate reductase |
Human | E. coli |
Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2. | |||
TMPH-01994 |
GDI2 Protein, Human, Recombinant (His)
Rab GDP dissociation inhibitor beta,Guanosine diphosphate di... |
Human | P. pastoris (Yeast) |
Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. GDI2 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 52.7 kDa and the accession number is P50395. | |||
TMPH-00796 |
gltX1 Protein, Helicobacter pylori, Recombinant (His)
Glutamyl-tRNA synthetase 1,gltX1,Glutamate--tRNA ligase 1 |
Helicobacter pylori | P. pastoris (Yeast) |
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). | |||
TMPH-00679 |
Peptide deformylase Protein, E. coli O157:H7, Recombinant (His)
Polypeptide deformylase,Peptide deformylase,def |
E. coli | P. pastoris (Yeast) |
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. | |||
TMPH-00726 |
Ribokinase Protein, E. coli, Recombinant (His)
Ribokinase,rbsK |
E. coli | E. coli |
Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. | |||
TMPH-01623 |
GBA Protein, Human, Recombinant (His & Myc & SUMO)
Lysosomal acid glucosylceramidase,GBA1,Lysosomal galactosylc... |
Human | E. coli |
Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction tha... | |||
TMPH-00870 |
ILVBL Protein, Human, Recombinant (His)
IlvB-like protein,Acetolactate synthase-like protein,ILVBL,2... |
Human | E. coli |
Endoplasmic reticulum 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the phytosphingosine degradation pathway. ILVBL Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 70.7?kDa and the accession number is A1L0T0. | |||
TMPH-01624 |
GBA Protein, Human, Recombinant
Lysosomal glycosylceramidase,Acid beta-glucosidase,Alglucera... |
Human | E. coli |
Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction tha... | |||
TMPH-02279 |
YARS1 Protein, Human, Recombinant (GST)
Tyrosine--tRNA ligase, cytoplasmic,Tyrosyl-tRNA synthetase,Y... |
Human | E. coli |
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). YARS1 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 86.0 kDa and the accession number is P54577. | |||
TMPH-03535 |
Dihydrofolate reductase Protein, S. aureus, Recombinant (His & Myc)
DHFR,Dihydrofolate reductase,folA |
Staphylococcus aureus | E. coli |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Dihydrofolate reductase Protein, S. aureus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 25.6 kDa and the accession number is P99079. | |||
TMPH-03595 |
APT Protein, S. pyogenes serotype M1, Recombinant (His & Myc)
Adenine phosphoribosyltransferase,apt,APRT |
Streptococcus pyogenes | P. pastoris (Yeast) |
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. APT Protein, S. pyogenes serotype M1, Recombinant (His & Myc) is expressed in yeast with N-10xHis and C-Myc tag. The predicted molecular weight is 22.7 kDa and the accession number is P63546. | |||
TMPY-04137 |
ATP6V1F Protein, Human, Recombinant (GST)
Vma7,ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F,... |
Human | E. coli |
ATP6V1F encodes a component of vacuolar ATPase mediating acidification. The cDNA and the genomic sequences of ATP6V1F were cloned successfully for the first time from the Giant Panda (Ailuropoda melanoleuca) using reverse transcription polymerase chain reaction and touchdown-polymerase chain reaction, respectively. Topology prediction showed that there is one protein kinase C phosphorylation site, two Casein kinase II phosphorylation sites, and one N-myristoylation site in the ATP6V1F protein. U... | |||
TMPH-02554 |
BCAT2 Protein, Mouse, Recombinant (His & Myc)
Bcat2,BCAT(m),Eca40,Branched-chain-amino-acid aminotransfera... |
Mouse | E. coli |
Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids. BCAT2 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 48.2 kDa and the accession number is O35855. | |||
TMPH-00722 |
PykF Protein, E. coli, Recombinant (His)
Pyruvate kinase I,PK-1,pykF |
E. coli | E. coli |
Catalyzes the formation of pyruvate in the last step of glycolysis, it is irreversible under physiological conditions. The reaction is critical for the control of metabolic flux in the second part of glycolysis. | |||
TMPH-03109 |
GPX5 Protein, Pig, Recombinant (His & Myc)
GPX5,Epididymis-specific glutathione peroxidase-like protein... |
Sus scrofa (Pig) | P. pastoris (Yeast) |
May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids. Since the purified porcine enzyme has very little activity towards hydrogen peroxide or organic hydroperoxides the protective effect is not likely to be exerted by its enzymatic activity. Instead, may protect sperm from premature acrosome reaction in the epididymis by binding to lipid peroxides, which might otherwise interact with phospholipase A2 and induce the acrosome reaction. GPX... | |||
TMPH-03524 |
KAS III Protein, S. aureus, Recombinant (His & Myc)
3-oxoacyl-[acyl-carrier-protein] synthase 3,3-oxoacyl-[acyl-... |
Staphylococcus aureus | E. coli |
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids. KAS III Protein, S. au... | |||
TMPH-03512 |
GT Protein, Solanum melongena, Recombinant (His & Myc)
GT,UDP-glucose flavonoid 3-O-glucosyltransferase,Anthocyanid... |
Solanum melongena | Baculovirus Insect Cells |
In the presence of other necessary color factors, this glycosylation reaction allows the accumulation of anthocyanin pigments. GT Protein, Solanum melongena, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 52.2 kDa and the accession number is Q43641. | |||
TMPH-02885 |
SOSTDC1 Protein, Mouse, Recombinant (His & Myc)
Sclerostin-like protein,Sostdc1,Sclerostin domain-containing... |
Mouse | E. coli |
May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling. Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner. | |||
TMPH-03367 |
SOSTDC1 Protein, Rat, Recombinant (His & Myc)
Sostdc1,Sclerostin domain-containing protein 1,Wnt-signaling... |
Rat | HEK293 Cells |
Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner. May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling. SOSTDC1 Protein, Rat, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 24.6 kDa and the accession number is Q642G2. | |||
TMPH-03581 |
Dihydrofolate reductase Protein, S. epidermidis, Recombinant (His)
dfrC,folA1,Dihydrofolate reductase,folA,DHFR |
Staphylococcus epidermidis | E. coli |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Dihydrofolate reductase Protein, S. epidermidis, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 22.0 kDa and the accession number is P0C0P1. | |||
TMPH-00335 |
FBA1 Protein, Candida albicans, Recombinant (His & Myc)
Fructose-1,6-bisphosphate aldolase,IgE-binding allergen,Fruc... |
Candida albicans | E. coli |
Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. FBA1 Protein, Candida albicans, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 46.5 kDa and the accession number is Q9URB4. | |||
TMPH-01565 |
IARS Protein, Human, Recombinant (His & Myc)
Isoleucine--tRNA ligase, cytoplasmic,Isoleucyl-tRNA syntheta... |
Human | E. coli |
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. | |||
TMPY-04767 |
PMVK Protein, Human, Recombinant (His)
PMK,PMKA,phosphomevalonate kinase,HUMPMKI,PMKASE |
Human | E. coli |
PMVK is a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Studies in rat show that the message level and the enzyme activity of PMVK is regulated by sterol, and that this regulation is coordinated with 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol biosynthesis. | |||
TMPJ-00725 |
HGPRT Protein, Human, Recombinant (His)
HGPRT,Hypoxanthine-Guanine Phosphoribosyltransferase,HPRT,HG... |
Human | E. coli |
Hypoxanthine-Guanine Phosphoribosyltransferase (HGPRT) has an important role in the generation of purine nucleotides through the purine salvage pathway. HPRT1 functions to salvage purines from degraded DNA to renewed purine synthesis, it acts as a catalyst in the reaction between guanine and phosphoribosyl pyrophosphate to form GMP. | |||
TMPH-03097 |
Beta-elicitin cryptogein Protein, Phytophthora cryptogea, Recombinant (His & Myc)
Beta-elicitin cryptogein,CRY |
Phytophthora cryptogea | E. coli |
Induces local and distal defense responses (incompatible hypersensitive reaction) in plants from the solanaceae and cruciferae families. Elicits leaf necrosis and causes the accumulation of pathogenesis-related proteins. Might interact with the lipidic molecules of the plasma membrane. Beta-elicitin cryptogein Protein, Phytophthora cryptogea, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 17.3 kDa and the accession... | |||
TMPH-03352 |
KLKB1 Protein, Rat, Recombinant (His)
Fletcher factor,Klkb1,Plasma prekallikrein,Kininogenin,Plasm... |
Rat | P. pastoris (Yeast) |
The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. KLKB1 Protein, Rat, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 29.8 kDa and the accession number is P14272. | |||
TMPH-02615 |
CBS Protein, Mouse, Recombinant (His)
Cystathionine beta-synthase,Serine sulfhydrase,Beta-thionase... |
Mouse | E. coli |
Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons. | |||
TMPH-03087 |
ODH1 Protein, Pecten maximus, Recombinant (His & Myc)
Octopine dehydrogenase,odh1 |
Pecten maximus | E. coli |
Catalyzes the reverse reaction of octopine dehydrogenation. Acts on L-arginine in preference to other substrates such as canavanine, cysteine, L-alanine, ornithine or norvaline, owing to the presence of the positively charged guanidium group. ODH1 Protein, Pecten maximus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 50.8 kDa and the accession number is Q9BHM6. | |||
TMPH-01553 |
GBP2 Protein, Human, Recombinant (E. coli, His)
Interferon-induced guanylate-binding protein 2,GBP2,Guanylat... |
Human | E. coli |
Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes. GBP2 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 22.4 kDa and the accession number is P32456. | |||
TMPH-03351 |
KLKB1 Protein, Rat, Recombinant (E. coli, His)
Plasma prekallikrein,Klkb1,Kininogenin,Plasma kallikrein,Fle... |
Rat | E. coli |
The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. KLKB1 Protein, Rat, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.8 kDa and the accession number is P14272. | |||
TMPH-02499 |
Allergin-1 Protein, Mouse, Recombinant (His & Myc)
Mca32,Gm885,Allergy inhibitory receptor 1,Mast cell immunogl... |
Mouse | E. coli |
Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction. Allergin-1 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 20.1 kDa and the accession number is Q3TB92. | |||
TMPY-02552 |
Adenylosuccinate Lyase Protein, Human, Recombinant (His)
ASL,adenylosuccinate lyase,ASASE,AMPS |
Human | E. coli |
Adenylosuccinate lyase, also known as adenylosuccinase, ADSL or ASL, is an enzyme implicated in the reaction of adenylosuccinat converting to AMP and fumarate as part of the purine nucleotide cycle. The two substates of adenylosuccinate lyase (ADSL) are dephosphorylated derivatives of SAICA ribotide (SAICAR) and adenylosuccinate (S-AMP), which catalyzes an important reaction in the de novo pathway of purine biosynthesis. ADSL catalyzes two distinct reactions in the synthesis of purine nucleotide... | |||
TMPH-00840 |
MAT2A Protein, Human, Recombinant (E. coli, His)
Methionine adenosyltransferase II,MAT2A,S-adenosylmethionine... |
Human | E. coli |
Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. MAT2A Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 44.8 kDa and the accession number is P31153. | |||
TMPH-03237 |
Orm1 Protein, Rat, Recombinant (His)
Alpha-1-acid glycoprotein,Orosomucoid,Orm1 |
Rat | E. coli |
Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Appears to function in modulating the activity of the immune system during the acute-phase reaction. Orm1 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 25.7 kDa and the accession number is P02764. | |||
TMPJ-00872 |
MGMT Protein, Human, Recombinant (His)
MGMT,6-O-methylguanine-DNAmethyltransferase,O-6-methylguanin... |
Human | E. coli |
MGMT belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. MGMT involved in the cellular defense against the biological effects of O6-methylguanine in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. MGMT catalyzes the chemical reaction: DNA (containing 6-O-methylguanine) and proteinL-cysteine into DNA (without 6-O-methylguanine) and protein S-met... | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
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TMIJ-0391 |
Acrylamide-2,3,3-d3
|
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Acrylamide-2,3,3-d3 是 Acrylamide 的氘代化合物。Acrylamide 的 CAS 号为 79-06-1。Acrylamide monomer 是丙烯酰胺类的成员。它具有致癌剂、神经毒素、诱变剂、烷化剂和美拉德反应产物的作用。 | |||
TMID-0061 |
MK7-d7
|
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MK7-d7 是 MK7 的氘代化合物。MK7 的 CAS 号为 2124-57-4。Menaquinone-7 是一种最早作为抗出血因子被发现的维生素K2家族成员。它是Gla-蛋白羧化反应中最具生物活性的辅因子,补充它也是激活Gla基质蛋白并干预钙化性主动脉瓣狭窄(CAVS)进展的一种药理选择。 | |||
TMIH-0457 |
Proguanil-d6 HCl
|
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Proguanil-d6 HCl 是 Proguanil HCl 的氘代化合物。Proguanil HCl 的 CAS 号为 637-32-1。Proguanil hydrochloride 是一种双胍类抗疟疾剂,在体内代谢形成环胍。它还是一种二氢叶酸还原酶抑制剂。 | |||
TMID-0167 |
6-Hydroxypurine-d4
|
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6-Hydroxypurine-d4 是 6-Hydroxypurine 的氘代化合物。6-Hydroxypurine 的 CAS 号为 68-94-0。Hypoxanthine,也被称为 purine-6-ol 或 Hyp,属于嘌呤类有机化合物。Hypoxanthine 是一种天然存在的嘌呤衍生物,是腺苷代谢和核苷酸补救途径形成核酸的反应中间体。在正常情况下,Hypoxanthine 很容易转化为尿酸。Hypoxanthine 首先被氧化为黄嘌呤,黄嘌呤再被黄嘌呤氧化酶氧化为尿酸。 |