134
18
49
3
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T39009 |
CAP18 (rabbit)
CAP18 (rabbit) |
||
CAP18 (rabbit) is a 37 amino acid antimicrobial peptide derived from rabbit granulocytes. It exhibits extensive antimicrobial activity against both Gram-positive (IC50, 130-200 nM) and Gram-negative (IC50, 20-100 nM) bacteria. Thus, CAP18 (rabbit) holds promise for the study and advancement of bacterial sepsis research. | |||
TP1175 |
Endothelin-3, human, mouse, rabbit, rat
Endothelin 3 (Rat,Human) |
||
Endothelin-3, human, mouse, rabbit, rat , is a cyclic 21 amino acid peptide. It is an endogenous neuropeptide and potent vasoconstrictor. | |||
TP1173 |
Endothelin 3 (Rat,Human) (TFA)
Endothelin-3, human, mouse, rabbit, rat TFA |
||
Endothelin-3, human, mouse, rabbit, rat TFA is a 21-amino acid vasoactive peptide that specifically interacts with G-protein-linked transmembrane receptors, ET-RA and ET-RB. | |||
T34862 |
Thromboxane A2
Rabbit aorta contracting substance,TXA-2,TXA2,TXA 2 |
Others | Others |
Thromboxane A2, as an unstable intermediate between the prostaglandin endoperoxides and thromboxane B2, is a potent inducer of platelet aggregation and causes vasoconstriction. | |||
T16420 |
P-1075
|
Potassium Channel | Membrane transporter/Ion channel |
P-1075 是磺酰脲受体2相关的 ATP 敏感性的钾通道(SUR2-KIR6)的激活剂,EC50为 45 nM。它在兔子中通过打开线粒体 K (ATP) 通道产生活性氧,产生保护心脏的功效。 | |||
TP1016 |
Aviptadil
Vasoactive Intestinal Peptide (human, rat, mouse, rabbit, canine, porcine),阿肽地尔 |
||
Aviptadil (INN) is an analog of vasoactive intestinal polypeptide (VIP) for the treatment of erectile dysfunction. | |||
T81316 |
Rabbit neutrophil peptide 3b
|
||
Rabbit Neutrophil Peptide 3b,一种源自兔腹膜中性粒细胞的抗菌肽。 | |||
T81317 |
Rabbit IgG1 kappa, Isotype Control
|
||
RabbitIgG1kappa, Isotype Control为兔源IgG1κ同型对照单克隆抗体,用于科研中作为Rabbit IgG1κ抗体的实验对照。 | |||
T1736 |
Apixaban
阿哌沙班,BMS-562247-01 |
Factor Xa | Metabolism |
Apixaban (BMS-562247-01) 是一种高度选择性,可逆的、口服具有活力的凝血因子 Xa (Factor Xa) 抑制剂,抑制人和兔凝血因子 Xa 的 Ki 分别为 0.08 nM 和 0.17 nM。它可以用于研究各种血栓栓塞疾病。 | |||
T7530 |
PD146176
NSC168807 |
Ferroptosis; Lipoxygenase; Autophagy | Apoptosis; Autophagy; Metabolism |
PD146176 (NSC-168807) 是一种 15-脂氧合酶(15-LO)抑制剂,抑制兔网织红细胞 15-LO,Ki 为 197 nM,IC50 为 0.54 μM。 它通过刺激老年三重转基因小鼠的自噬来逆转认知障碍、脑淀粉样变性和 tau 病理学。 | |||
T76500 |
ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat)
|
||
ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat) 是ACTH的3-24片段,适用于癌症、免疫疾病、心血管疾病等多种疾病的研究。 | |||
T64587 |
p44/42 MAPK (Erk1/2) (137F5) Rabbit mAb #4695R
|
Others | Others |
p44/42 MAPK (Erk1/2) (137F5) Rabbit mAb #4695R 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T64587。 | |||
T64611 |
Acetyl-Histone H3 (Lys9) (C5B11) Rabbit mAb #9649R
|
Others | Others |
Acetyl-Histone H3 (Lys9) (C5B11) Rabbit mAb #9649R 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T64611。 | |||
T81591 |
Osteostatin (1-5) amide (human, bovine, dog, horse, mouse, rabbit, rat)
Human PTHrP(107-111) amide |
||
Osteostatin (1-5) amide (human, bovine, dog, horse, mouse, rabbit, rat) (Human PTHrP (107-111) amide) 是一段具有抑制骨吸收作用的C端甲状旁腺激素相关蛋白片段。 | |||
T64608 |
Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (20G11) Rabbit mAb #4376R
|
Others | Others |
Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (20G11) Rabbit mAb #4376R 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T64608。 | |||
TP1016L |
Aviptadil Acetate
醋酸阿肽地尔,阿肽地尔,Vasoactive Intestinal Peptide acetate salt |
RAAS; SARS-CoV | Endocrinology/Hormones; Microbiology/Virology |
Aviptadil Acetate (Vasoactive Intestinal Peptide acetate salt) 是模拟血管活性肠多肽类似物,具有血管舒张效应。它可诱导肺血管舒张并抑制血管 SMC 的增殖和血小板聚集。它可用于研究 SARS-CoV-2 引起的肺纤维化、肺动脉高压和呼吸衰竭。 | |||
T17196 |
UC-1728
t-TUCB |
Epoxide Hydrolase | Metabolism |
UC-1728 (t-TUCB) 是一种兔子可溶性环氧化物水解酶抑制剂,兔子肝脏中测得其IC50=2 nM。 | |||
T13373 |
YM17E
|
Acyltransferase; AChR | Metabolism; Neuroscience |
YM17E 是一种 ACAT 抑制剂,在体外兔肝微粒体中的 IC50 为 44 nM。 | |||
T3757 |
NQ301
|
Thrombin; Platelet aggregation | Others; Proteases/Proteasome |
NQ301 是一种抗血栓剂,能够抑制胶原蛋白激发的兔血小板聚集,IC50=10 mg/mL。 | |||
T16411 |
Otenzepad
AF-DX 116 |
AChR | Neuroscience |
Otenzepad (AF-DX 116) 是 M2 mAChR 的特异性拮抗剂,对大鼠心脏和兔外周肺的 IC50 分别为 386 nM 和 640 nM。 | |||
T12767 |
RP 70676
|
Acyltransferase | Metabolism |
RP 70676 是ACAT 抑制剂,抑制大鼠和兔子中 ACAT 的IC50分别为 25 和 44 nM。 | |||
T67805 |
Oxepinac
|
Others | Others |
oxepinac 是一种治疗疼痛性骨关节炎的有效且耐受性良好的化合物。oxepinac 在动物实验中对小鼠和家兔胎儿无致畸作用。 | |||
TQ0038 |
Brensocatib
AZD7986,INS 1007 |
Proteasome | Proteases/Proteasome; Ubiquitination |
Brensocatib (AZD7986) 是一种二肽基肽酶 1 (DPP1) 抑制剂,在人,小鼠,大鼠,狗和兔中的pIC50分别为 6.85, 7.6, 7.7, 7.8 和 7.8。 | |||
TP1917L1 |
Sar-[D-Phe8]-des-Arg9-Bradykinin acetate
Sar-[D-Phe8]-des-Arg9-Bradykinin acetate(126959-88-4 free base) |
Bradykinin Receptor | GPCR/G Protein |
Sar-[D-Phe8]-des-Arg9-Bradykinin acetate(126959-88-4 free base) 是一种有效的选择性缓激肽 B1 受体激动剂(兔主动脉中的 EC50 = 9.02 nM),对氨肽酶、激肽酶 I 和 II (ACE) 以及中性内肽酶切割具有抗性。在体内表现出降血压和血管生成活性。 | |||
T22964 |
Glemanserin
MDL11939 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Glemanserin (MDL11939) 是一种特异性 5-HT2A 拮抗剂,对兔、人和大鼠 5-HT2A 的 Ki 值为 0.54 nM、2.5 nM 和 2.89 nM。 | |||
T15338 |
Foropafant
SR27417,福罗帕泛 |
Others; Platelet aggregation | Others |
Foropafant (SR27417) 是一种高效和特异性的血小板活化因子 (PAF) 受体拮抗剂 (Ki: 57 pM)。 Foropafant 有效抑制 PAF 诱导的兔和人血小板聚集。 | |||
T31597 |
Ecabapide
DQ2511,DQ 2511,DQ-2511 |
Others | Others |
Ecabapide (DQ-2511) 是一种新型促胃肠蠕动剂,能显著增强SHRSP的胃排空能力。Ecabapide 可激活的兔胃壁细胞中的环状 GMP 依赖性管家 Cl- 通道。 | |||
T14506 |
BAY 60-6583
|
Others; Adenosine Receptor | GPCR/G Protein; Neuroscience; Others |
BAY 60-6583 是一种强效、高亲和力的腺苷 A2B 受体激动剂(EC50 = 3 nM),对A2B 受体的亲和力超过对 A1、A2A 和 A3 受体的亲和力。BAY 60-6583 在心肌缺血模型中具有心脏保护作用。BAY 60-6583 与小鼠、兔子和狗 A2BAR 的结合 Ki 值分别为 750 nM、340 nM 和 330 nM。 | |||
T25102 |
Aprikalim
RP-52891,RP 52891,RP52891 |
Potassium Channel | Membrane transporter/Ion channel |
Aprikalim (RP 52891) 是一种三磷酸腺苷钾通道(KATP)开启剂,可保护脊髓缺血兔模型中的神经受到损伤。Aprikalim 抑制血管收缩,抑制心肌麻痹期间 [Ca2+]i 升高,可以用于研究心血管疾病。 | |||
T9901A-008 |
Volociximab
Eos 200-4,M200 |
Integrin | Cytoskeletal Signaling |
Volociximab (M200) 是一种靶向 α5β1 整合素的 IgG4 单克隆抗体 ,具有抗血管生成、抗肿瘤和抗癌活性,可抑制兔子 VX2 肿瘤的生长,用于研究实体瘤。 | |||
T16865 |
SCH28080
|
ATPase; Proton pump | Membrane transporter/Ion channel |
SCH28080 是一种可逆且具有 K+ 竞争性的胃 H+/K+-ATP 酶 (H+/K+-ATPase) 抑制剂,IC50 值为 20 nM (家兔微粒体膜)。SCH28080 在体内是有效的酸分泌抑制剂,具有抗溃疡活性、抗分泌和细胞保护活性。 | |||
T6236 |
Ozagrel
奥扎格雷,OKY-046,Domenan |
Thrombin; Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation; Proteases/Proteasome |
Ozagrel (Domenan) 是血栓烷 A2(TXA2) 合酶抑制剂,可抑制哮喘。它也是一种抗血小板剂,可选择性抑制人血小板聚集,IC50为 53.12 μM。 | |||
T30249 |
AZD 7009
AZD-7009,AZD7009 |
Sodium Channel | Membrane transporter/Ion channel |
AZD 7009是一种新型抗心律失常化合物,对CHO K1细胞中 hNav1.5的钠电流具有抑制作用,IC50为11 uM。AZD 7009 对离体兔心房和心室肌细胞的晚期钠电流具有抑制作用,对e -4031诱导的动作电位持续时间延长具有抑制作用,促使浦肯野纤维的早期后去极化(EADs)。 | |||
T11918L |
Lysipressin acetate(50-57-7(fb_acetate))
Lysine vasopressin acetate,[Lys8]-Vasopressin acetate |
Others | Others |
Lysipressin acetate(50-57-7(fb_acetate)) ([Lys8]-Vasopressin acetate) 诱导兔膀胱平滑肌收缩,激活腺苷酸环化酶。 Lysipressin 是一种抗利尿激素,已在猪和一些有袋动物家族中发现。 | |||
T22530 |
6-Chloromelatonin
|
Melatonin Receptor; Dopamine Receptor | GPCR/G Protein; Neuroscience |
6-Chloromelatonin 是一种有效的褪黑素受体 (melatonin receptor) 激动剂,是一种5-甲氧基吲哚化合物,可竞争兔视网膜中相同的突触前褪黑激素受体位点 ,可抑制[3H]多巴胺的钙依赖性释放 具有比褪黑素更高的代谢稳定性。6-Chloromelatonin 竞争 [3H] 褪黑素 与 MT2 受体结合 (pKi=9.77),可能用于研究与抑郁症相关的失眠和睡眠障碍。 | |||
T21871 |
MMPSI
Caspase-3/7 Inhibitor I |
Apoptosis; Caspase | Apoptosis; Proteases/Proteasome |
MMPSI (Caspase-3/7 Inhibitor I) 是一种新型的、非肽类的小分子 caspase 3 和 caspase 7 抑制剂,可减少离体兔心脏或心肌细胞缺血性损伤的作用,以浓度依赖性方式抑制 H16c2 细胞凋亡 。MMPSI 可用于研究心脏保护和心肌损伤。 | |||
T35841 |
5-Benzyloxygramine
|
Dopamine Receptor; 5-HT Receptor | GPCR/G Protein; Neuroscience |
5-Benzyloxygramine 是一种 N 蛋白、蛋白互作的原位稳定剂,具有抗病毒和稳定 N-NTD 蛋白的作用。它能够阻断多巴胺受体,可拮抗 5-HT 对大鼠子宫和兔耳的作用。 | |||
T16240 |
N,N'-Diacetyl-L-cystine
(Ac-Cys-OH)2,DiNAC |
Others | Others |
N,N'-Diacetyl-L-cystine (DiNAC) 是一种具有免疫调节特性的 N-乙酰基半胱氨酸的二硫二聚体。它在高脂血症兔中也具有抗动脉粥样硬化的作用。它是啮齿类动物中接触敏感/迟发型超敏反应的有效口服活性调节剂。 | |||
TP1937L1 |
RFRP-1 (human) acetate(311309-25-8 free base)
|
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
RFRP-1 (human) acetate(311309-25-8 free base) 是一种有效的内源性 NPFF 受体激动剂(NPFF2 和 NPFF1 的 EC50 值分别为 0.0011 和 29 nM)。它减弱离体大鼠和兔心肌细胞的收缩功能。降低心率、每搏输出量、射血分数和心输出量,并增加大鼠的血浆催乳素水平。 GnIH 同系物。 | |||
T10421 |
AVE5688
|
Phosphorylase | Metabolism |
AVE5688 是糖原磷酸化酶 (glycogen phosphorylase (GP)) 抑制剂,抑制兔肌肉糖原磷酸化酶 rmGPb 和 rmGPa 的活性,IC50 值分别为 430 nM 和 915 nM,Kd 值分别为 170 nM 和 530 nM;AVE5688 可用于二型糖尿病的研究。 | |||
T24906L |
Tuna AI acetate
|
Angiotensin-converting Enzyme (ACE) | Metabolism |
Tuna AI acetate 是一种源自金枪鱼肌肉的非竞争性血管紧张素转换酶 (ACE) 抑制剂。 | |||
T6035 |
Odanacatib
奥达卡替,奥当卡替,MK-0822 |
Cysteine Protease | Proteases/Proteasome |
Odanacatib 是组织蛋白酶K(人/兔)的选择性抑制剂,IC50分别为0.2 nM 和 1 nM。 | |||
T13369 |
YM-264
|
Others | Others |
YM-264 is a selective and orally active antagonist of platelet-activating factor (PAF) (pKi value of 8.85 for rabbit platelet membranes). | |||
T13160 |
Timegadine
替美加定,SR1368 |
COX | Immunology/Inflammation; Neuroscience |
Timegadine is a competitive inhibitor of COX and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates and in washed rabbit platelets. | |||
T39223 |
Milvexian
JNJ-70033093,BMS-986177 |
Others | Others |
Milvexian (BMS-986177) is a potent antithrombotic compound that inhibits human and rabbit factor XIa (FXIa) directly and reversibly. It is orally-bioavailable and exhibits a K i of 0.11 nM and 0.38 nM against human and rabbit FXIa, respectively. | |||
T20697 |
Robenidine
Chimcoccide,Khimcoccid |
Others | Others |
Robenidine, an anticoccidial guanidine, is used as an additive in rabbit fodder. | |||
T27574 |
ZM 169369
ICI169369,ICI-169369 |
Others | Others |
ICI 169369, a 5-HT2/5-HT1C antagonist, can evoke endothelium-dependent relaxation in rabbit aorta. | |||
T37210 |
5-hydroxy Indomethacin
|
Others | Others |
5-hydroxy Indomethacin is a metabolite of indomethacin .1It is formed from indomethacin in rabbit hepatic microsomes. 1.Evans, M.A., Papazafiratou, C., Bhat, R., et al.Indomethacin metabolism in isolated neonatal and fetal rabbit hepatocytesPediatr. Res.15(11)1406-1410(1981) | |||
T13129 |
Terodiline hydrochloride
|
AChR | Neuroscience |
Terodiline hydrochloride is an antagonist of M1-selective muscarinic receptor (mAChR)(Kbs of 15, 160, 280, and 198 nM in rabbit vas deferens (M1), atria (M2), bladder (M3) and ileal muscle (M3), respectively). | |||
T26621 |
AMP-579
RPR100579,RPR 100579,AMP 579,RPR-100579 |
Others | Others |
AMP-579 is an adenosine A1 receptor agonist. AMP-579 also acts as a A2b-adenosine receptor agonist in human 293 cells and rabbit hearts. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4850 |
PCL 016
2-吡啶甲酸,2-Picolinic acid |
Virus Protease; Endogenous Metabolite | Metabolism; Microbiology/Virology |
PCL 016 (2-Picolinic acid) 是一种局部抗病毒剂,可抑制兔体内的腺病毒复制。 | |||
TN1528 |
Cotoin
|
AChE | Neuroscience |
Cotoin 是从 Garcinia virgate 茎皮中分离出的一种天然产物。Cotoin 具有解痉活性,可降低孤立的兔肠的音调和收缩。它部分抑制乙酰胆碱、毛果芸香碱和 BaCl 对分离肠的影响。 | |||
T7030 |
anemarsaponin B
知母皂苷B,知母皂苷 B |
p38 MAPK; NF-κB; MEK; COX; NO Synthase | Immunology/Inflammation; MAPK; Neuroscience; NF-κB |
Anemarsaponin B 是一种甾体皂苷,可降低iNOS 和COX-2的蛋白和 mRNA 水平,减少促炎细胞因子的表达和产生。它通过阻断 IκBα 的磷酸化来抑制NF-κB 的 p65 亚基的核转位,还抑制 MAP 激酶激酶 3/6 (MKK3/6) 和混合谱系激酶 3 的磷酸化。 | |||
T3S1967 |
(S)-Indoximod
N-ME-Tryptophan,Abrine,相思豆碱,L-Abrine |
Others; Indoleamine 2,3-Dioxygenase (IDO) | Metabolism; Others |
(S)-Indoximod (L-Abrine) 是一种吲哚胺-2,3-双加氧酶 (IDO) 抑制剂,可用于研究癌症。 | |||
T6S0033 |
Crotonoside
巴豆苷;异鸟苷,巴豆苷,Isoguanosine,2-HYDROXYADENOSINE |
Others; FLT; HDAC | Angiogenesis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Others; Tyrosine Kinase/Adaptors |
Crotonoside (Isoguanosine) 是从中草药巴豆中分离出来的一种天然产物。 它抑制 FLT3 和 HDAC3/6,有治疗急性髓性白血病 (AML)的研究潜力。 | |||
TN6575 |
Pilosidine
|
||
Pilosidine has vasoconstrictor activity, it showed facilitating effect on adrenaline evoked contractions in rabbit aorta isolated preparations. | |||
T27436 |
GS 389
GS-389,GS389 |
Others | Others |
GS 389 is a novel tetrahydroisoquinoline analog with vasorelaxant properties. GS-389 significantly inhibited cGMP phosphodiesterase from the rabbit brain and increased cGMP levels in the rat aorta. | |||
TN7543 |
(S)-Laudanosine
NSC 35045,L-(+)-Laudanosine,(+)-Laudanosine,L-Laudanosine |
Others | Others |
(S)-Laudanosine, the (S) enantiomer of laudanosine, emerges as a metabolite from the neuromuscular blocking agents atracurium and cisatracurium. It functions by inhibiting prolyl endopeptidase and obstructing arachidonic acid- and collagen-induced aggregation in washed rabbit platelets. | |||
T10913 |
Cyclobuxine D
|
Others | Others |
Cyclobuxine D is a steroidal alkaloid extracted from Buxus microphylla. Cyclostatin D has obvious bradycardia effect on rat heart, and inhibits acetylcholine and Ba ++ induced longitudinal muscle contraction isolated from rabbit jejunum. | |||
TN1980 |
Neocryptotanshinone
|
Others | Others |
Neocryptotanshinone inhibits rabbit platelet aggregation induced by arachidonic acid. | |||
TN4794 |
Pinusolidic acid
|
PAFR | GPCR/G Protein |
Pinusolidic acid shows a potent inhibitory effect on platelet activating factor (PAF) binding to rabbit platelets (IC50 = 2.3 x 10(-5) M, 7.48 +/- 2.11 micrograms/ml). | |||
T75570 |
Justicidin C
|
Others | Others |
Justicidin C 是一种抗病毒木脂素,对水泡性口炎病毒展现了较强的抗病毒活性,同时在兔肺细胞(RL-33)中显示较低的细胞毒性。 | |||
T79950 |
Piperulin A
|
Others | Others |
Piperulin A,作为一种有效的PAFR抑制剂,其通过抑制兔血小板质膜上PAFR的特异性结合,展现出其功能,IC50值为7.3 μM。 | |||
TN3568 |
Calceolarioside A
|
Calcium Channel; Antifection | Membrane transporter/Ion channel; Metabolism; Microbiology/Virology |
Calceolarioside A shows potent activity against visceral leishmaniasis. It can induce a dose-related aggregant effect on rabbit platelets, which may be partly related to a calcium-dependent mechanism. Calceolarioside A also has potent antioxidative activi | |||
T83460 |
11-O-β-D-glucopyranosyl thamnosmonin
|
||
11-O-β-D-glucopyranosyl thamnosmonin是一种香豆素苷,能够从Angelica apaensis根部提取。该化合物对PAF、AA和ADP诱发的兔血小板聚集表现出轻度的抑制效果。 | |||
TN4937 |
Sambutoxin
|
Others | Others |
Sambutoxin, a new mycotoxin produced by toxic Fusarium isolates obtained from rotted potato tubers, it can cause toxic effects in rats, including body weight loss, feed refusal, hemorrhage in the stomach and intestines, and, finally, death when rats were | |||
T38330 |
Collinin
|
Others | Others |
Collinin is a coumarin that has been found in Z. schinifolium and has diverse biological activities.1,2,3,4 It is active against drug-susceptible and -resistant strains of M. tuberculosis (MIC50s = 3.13-6.25 μg/ml).1 Collinin inhibits LPS-induced nitric oxide (NO) production (IC50 = 5.9 μM) and reduces COX-2 protein levels in RAW 264.7 cells.2 It completely inhibits aggregation of isolated rabbit platelets induced by arachidonic acid , collagen, or platelet activating factor (PAF) when used at a... | |||
T83915 |
Norbixin hydrate
|
Others | Others |
Norbixin是一种在B. orellana中发现的类胡萝卜素,具有多样的生物活性。在无细胞测试中,它与过氧化物酶体增殖物激活受体γ (PPARγ)结合(Ki = 1.15 µM)。在心脑血管代谢综合征大鼠模型中,Norbixin (47.7 mg/kg) 能够减轻高血糖、高胰岛素血症和胰岛素抗性,降低血清脂质水平及心脏中硫代巴比妥酸反应性物质(TBARS)和谷胱甘肽(GSH)的水平。在胆固醇诱导的动脉粥样硬化兔模型中,它降低氧化型LDL和主动脉蛋白氧化水平,并减少动脉粥样硬化面积。Norbixin(每天0.1和1 mg/kg)减少汞诱导的大鼠肝细胞和白细胞DNA损伤。此外,它还能预防与年龄相关的黄斑变性(AMD)Abca4-/- Rdh8-/-小鼠模型中的光感受器退化。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00779 |
TNF alpha Protein, Rabbit, Recombinant
TNF-a,Tumor Necrosis Factor,TNF-α,TNF α,Cachectin,肿瘤坏死因子,Tum... |
Rabbit | E. coli |
Tumor necrosis factor alpha (TNFα) is the prototypic ligand of the TNF superfamily. TNFα forms a homotrimer and functions by activating two types of receptors TNF-R1 (TNF receptor type 1,p55R) and TNF-R2 (TNF receptor type 2,p75R). TNFα is a pleiotropic cytokine that is capable to promote inflammation, to induce apoptotic cell death, and to inhibit tumorigenesis and viral replication. TNFα is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells and certain other ... | |||
TMPY-03634 |
CD38 Protein, Rabbit, Recombinant (His)
CD38 molecule,ADPRC1 |
Rabbit | HEK293 Cells |
CD38 Protein, Rabbit, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 30.5 kDa and the accession number is Q9MZ03. | |||
TMPH-03202 |
DAG1 Protein, Rabbit, Recombinant (His)
Dystroglycan 1,Dystroglycan,Dystrophin-associated glycoprote... |
Rabbit | E. coli |
DAG1 Protein, Rabbit, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 73.5 kDa and the accession number is Q28685. | |||
TMPH-03211 |
TFPI Protein, Rabbit, Recombinant (His)
TFPI,Lipoprotein-associated coagulation inhibitor,Extrinsic ... |
Rabbit | HEK293 Cells |
Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. TFPI Protein, Rabbit, Recombinant (His) is expressed in HEK293 mammalian cells with N-10xHis tag. The predicted molecular weight is 35.4 kDa and the accession number is P19761. | |||
TMPY-04888 |
IL-17 Protein, Rabbit, Recombinant
白细胞介素,白介素,interleukin 17A |
Rabbit | E. coli |
IL-17 Protein, Rabbit, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.1 kDa and the accession number is G1SLF2. | |||
TMPY-04663 |
TrkA Protein, Rabbit, Recombinant (His)
neurotrophic tyrosine kinase, receptor, type 1 |
Rabbit | HEK293 Cells |
TrkA Protein, Rabbit, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.4 kDa and the accession number is XP_008262512.1. | |||
TMPH-03217 |
VEGFA Protein, Rabbit, Recombinant (His)
|
Rabbit | P. pastoris (Yeast) |
VEGFA Protein, Rabbit, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 51.7 kDa and the accession number is XP_002714743.1. | |||
TMPY-04609 |
IL-17 Protein, Rabbit, Recombinant (His)
白细胞介素,白介素,interleukin 17A |
Rabbit | Baculovirus Insect Cells |
IL-17 Protein, Rabbit, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 17.3 kDa and the accession number is G1SLF2. | |||
TMPJ-00959 |
B7-2 Protein, Rabbit, Recombinant (His)
CD86,T-lymphocyte activation antigen CD86,Activation B7-2 an... |
Rabbit | HEK293 Cells |
B7-2 Protein, Rabbit, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 38-70 KDa and the accession number is P42071. | |||
TMPH-03212 |
TPM1 Protein, Rabbit, Recombinant (His & Myc)
TPM1,Alpha-tropomyosin,Tropomyosin alpha-1 chain,Tropomyosin... |
Rabbit | Baculovirus Insect Cells |
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. TPM1 Protein, Rabbit, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 3... | |||
TMPH-03218 |
VEGFA Protein, Rabbit, Recombinant (His & SUMO)
|
Rabbit | E. coli |
N/A. VEGFA Protein, Rabbit, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 65.7 kDa and the accession number is XP_002714743.1. | |||
TMPH-03198 |
MGAT1 Protein, Rabbit, Recombinant (His & Myc)
MGAT1,Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosa... |
Rabbit | E. coli |
Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans. MGAT1 Protein, Rabbit, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 53.2 kDa and the accession number is P27115. | |||
TMPJ-00958 |
B7-1 Protein, Rabbit, Recombinant (His)
Activation B7-1 antigen,T-lymphocyte activation antigen CD80... |
Rabbit | HEK293 Cells |
Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily which plays key, yet distinct roles in the activation of T cells. B7-1/CD80 and B7-2/CD86, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T- and B- cell responses. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. Although both CTLA-4 and CD28 can ... | |||
TMPY-04831 |
NGFR/p75NTR Protein, Rabbit, Recombinant (hFc)
NGFR,nerve growth factor receptor (TNFR superfamily, member ... |
Rabbit | HEK293 Cells |
NGFR/p75NTR Protein, Rabbit, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.1 kDa and the accession number is XP_008269543.1. | |||
TMPY-04792 |
IL-23 Protein, Rabbit, Recombinant (His)
白介素,白细胞介素 |
Rabbit | HEK293 Cells |
IL-23 Protein, Rabbit, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 56.6 kDa and the accession number is XP_002710393.1&XP_002711125.1. | |||
TMPH-03203 |
FGFb Protein, Rabbit, Recombinant (His & SUMO)
Basic fibroblast growth factor,Fibroblast growth factor 2,FG... |
Rabbit | E. coli |
Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation. FGFb Protein, Rabbit, Recombinant (His & SUMO) is expressed in E. coli exp... | |||
TMPY-00259 |
IL-12B Protein, Rabbit, Recombinant (His)
interleukin 12B |
Rabbit | HEK293 Cells |
IL-12B Protein, Rabbit, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.1 kDa and the accession number is G1TBD7. | |||
TMPH-03210 |
TFPI Protein, Rabbit, Recombinant (E. coli, His)
Lipoprotein-associated coagulation inhibitor,Extrinsic pathw... |
Rabbit | E. coli |
Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. TFPI Protein, Rabbit, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 35.8 kDa and the accession number is P19761. | |||
TMPH-03208 |
IL-6 Protein, Rabbit, Recombinant (His)
Interleukin-6,IL6 |
Rabbit | P. pastoris (Yeast) |
IL-6 Protein, Rabbit, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 26.4 kDa and the accession number is Q9MZR1. | |||
TMPH-03207 |
IL-2 Protein, Rabbit, Recombinant (His)
T-cell growth factor,IL2,Interleukin-2 |
Rabbit | E. coli |
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. IL-2 Protein, Rabbit, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 19.1 kDa and the accession number is O77620. | |||
TMPY-05287 |
CD64A Protein, Rabbit, Recombinant (His)
|
Rabbit | HEK293 Cells |
CD64A Protein, Rabbit, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.2 kDa and the accession number is G1SJM8. | |||
TMPH-03199 |
APOE Protein, Rabbit, Recombinant (His & Myc & SUMO)
APOE,Apolipoprotein E,Apo-E |
Rabbit | E. coli |
APOE Protein, Rabbit, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 53.6 kDa and the accession number is P18287. | |||
TMPY-04646 |
NGFR/p75NTR Protein, Rabbit, Recombinant (His)
神经生长因子,nerve growth factor receptor (TNFR superfamily, membe... |
Rabbit | HEK293 Cells |
NGFR/p75NTR Protein, Rabbit, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24.8 kDa and the accession number is XP_008269543.1. | |||
TMPY-06738 |
Ory c 3 Protein, Rabbit, Recombinant
|
Rabbit | P. pastoris (Yeast) |
Ory c 3 Protein, Rabbit, Recombinant is expressed in P. pastoris yeast expression system. The predicted molecular weight is 18.3 kDa. | |||
TMPY-02318 |
Tissue Factor Protein, Rabbit, Recombinant (His)
coagulation factor III (thromboplastin, tissue factor) |
Rabbit | HEK293 Cells |
Tissue Factor Protein, Rabbit, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.4 kDa and the accession number is P24055. | |||
TMPH-03204 |
GHR Protein, Rabbit, Recombinant (His & Myc)
GHR,Somatotropin receptor,Growth hormone receptor |
Rabbit | E. coli |
Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway.; The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. GHR Protein, Rabbit, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 34.6 kDa and the accession number is P19941. | |||
TMPH-03201 |
CD40 Ligand Protein, Rabbit, Recombinant (His)
TNLG8B,CD40 ligand,CD40-L,CD40LG,Tumor necrosis factor ligan... |
Rabbit | P. pastoris (Yeast) |
N/A. CD40 Ligand Protein, Rabbit, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 18.2 kDa and the accession number is G1SKP7. | |||
TMPH-03209 |
CLNS1A Protein, Rabbit, Recombinant (His & Myc)
I(Cln),Chloride conductance regulatory protein ICln,Methylos... |
Rabbit | E. coli |
CLNS1A Protein, Rabbit, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 33.4 kDa and the accession number is Q28678. | |||
TMPH-03205 |
HINT1 Protein, Rabbit, Recombinant (His & Myc)
HINT1,Histidine triad nucleotide-binding protein 1,Desumoyla... |
Rabbit | HEK293 Cells |
HINT1 Protein, Rabbit, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 17.6 kDa and the accession number is P80912. | |||
TMPK-01310 |
Syndecan-1 Protein, Rabbit, Recombinant (His)
SDC1,SYND1,SDC,CD138,Syndecan 1 |
Rabbit | HEK293 Cells |
CD138 (syndecan-1, Sdc-1) is a member of the syndecan family that comprises heparan sulfate proteoglycans. CD138 is significant for cell-cell and cell-matrix interactions.CD138 plays a crucial role in carcinogenesis and is an attractive target for anticancer treatment with heparanase inhibitors and anti-CD138 antibodies for immunotherapy. | |||
TMPH-03206 |
ITGB8 Protein, Rabbit, Recombinant (His & Myc)
ITGB8,Integrin beta-8 |
Rabbit | E. coli |
Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs). Required during vasculogenesis. ITGB8 Protein, Rabbit, Recombinant (His & Myc) is expressed in E. coli ... | |||
TMPY-02697 |
IgG Protein, Rabbit, Recombinant (T185A, N284S)
IgG |
Rabbit | HEK293 Cells |
IgG Protein, Rabbit, Recombinant (T185A, N284S) is expressed in HEK293 mammalian cells. The predicted molecular weight is 25 kDa and the accession number is P01870. | |||
TMPY-04011 |
IL-1 beta/IL-1F2 Protein, Rabbit, Recombinant
白介素,IL1-β,interleukin 1, beta,interleukin 1, β,IL-1 β,白细胞介素,... |
Rabbit | E. coli |
IL-1 beta/IL-1F2 Protein, Rabbit, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.5 kDa and the accession number is P14628. | |||
TMPH-03215 |
OX40L/TNFSF4 Protein, Rabbit, Recombinant (hFc)
TNFSF4,OX40 ligand,Tumor necrosis factor ligand superfamily ... |
Rabbit | HEK293 Cells |
Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. TNFSF4 Protein, Rabbit, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 44.9 kDa and the accession number is O02765. | |||
TMPH-03216 |
OX40L/TNFSF4 Protein, Rabbit, Recombinant (His)
Tumor necrosis factor ligand superfamily member 4,TNFSF4,OX4... |
Rabbit | E. coli |
Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. TNFSF4 Protein, Rabbit, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 20.1 kDa and the accession number is O02765. | |||
TMPH-03214 |
OX40L/TNFSF4 Protein, Rabbit, Recombinant (His & Myc)
Tumor necrosis factor ligand superfamily member 4,TNFSF4,OX4... |
Rabbit | P. pastoris (Yeast) |
Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. TNFSF4 Protein, Rabbit, Recombinant (His & Myc) is expressed in yeast with C-6xHis, Myc tag. The predicted molecular weight is 19.8 kDa and the accession number is O02765. | |||
TMPH-03200 |
CD40 Ligand Protein, Rabbit, Recombinant (E. coli, His)
CD40LG,Tumor necrosis factor ligand superfamily member 5,TNL... |
Rabbit | E. coli |
N/A. CD40 Ligand Protein, Rabbit, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 20.2 kDa and the accession number is G1SKP7. | |||
TMPH-03213 |
TPM1 Protein, Rabbit, Recombinant (E. coli, His & Myc)
Tropomyosin alpha-1 chain,TPM1,Alpha-tropomyosin,Tropomyosin... |
Rabbit | E. coli |
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. TPM1 Protein, Rabbit, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular w... | |||
TMPY-06750 |
IL-18R beta/IL-18RAP Protein, Rabbit, Recombinant (His)
interleukin 18 receptor accessory protein,IL-18R β/IL-18RAP |
Rabbit | HEK293 Cells |
IL-18R beta/IL-18RAP Protein, Rabbit, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40.22 kDa and the accession number is G1SQ92. | |||
TMPY-00105 |
Recombinant Protein G
|
E. coli | |
Protein G is a bacterial cell wall protein expressed at the cell surface of certain group C and group G Streptococcal strains. It has affinity for both Fab- and Fc-fragments of human IgG by independent and separate binding sites. Binding to the Fc region of immunoglobulins from several species by a non-immune mechanism exhibits great affinity for almost all mammalian immunoglobulin G (IgG) classes, including all human IgG subclasses (IgG1, IgG2, IgG3 and IgG4) and also rabbit, mouse, and goat Ig... | |||
TMPY-03758 |
Vaccinia Virus B18R/B19R Protein (His)
|
VACV | Baculovirus Insect Cells |
B18R is a type I interferon (IFN)-binding protein, which is encoded by the B18R open reading frame in the WR (Western Reserve) strain of vaccinia virus. It is also known as B19R in the Copenhagen strain of Vaccinia. B18R exists in a soluble and a membrane-bound form. As a type I IFN receptor, B18R has a broad species specificity. It has high affinity for human IFN-alpha and also binds rabbit, bovine, rat, pig, and mouse IFN-alpha and IFN-beta. It has been shown that secreted B18R binds to un... | |||
TMPH-00825 |
Horcolin Protein, Hordeum vulgare subsp. Vulgare, Recombinant (His & Myc)
Agglutinin,Mannose-specific lectin,Horcolin |
Domesticated barley | E. coli |
Mannose-specific lectin. Has a weak agglutinating activity against rabbit erythrocytes. Horcolin Protein, Hordeum vulgare subsp. Vulgare, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 22.6 kDa and the accession number is P82953. | |||
TMPH-00173 |
Subtilosin-A Protein, Bacillus subtilis, Recombinant (His & KSI)
sboA,Antilisterial bacteriocin subtilosin,Subtilosin-A |
Bacillus subtilis | E. coli |
Has bacteriocidal activity against some Gram-positive bacteria such as Listeria, some species of Bacillus and E.faecium. A single mutation (Thr-14-Ile) confers hemolytic activity against rabbit and human blood. Subtilosin-A Protein, Bacillus subtilis, Recombinant (His & KSI) is expressed in E. coli expression system with N-6xHis-KSI tag. The predicted molecular weight is 18.8 kDa and the accession number is O07623. | |||
TMPH-03069 |
CSL3 Protein, Oncorhynchus keta, Recombinant (His)
L-rhamnose-binding lectin CSL3 |
Oncorhynchus keta | E. coli |
L-rhamnose binding lectin. Has hemagglutinating activity towards rabbit erythrocytes, human type A erythrocytes, human type B erythrocytes, human type O erythrocytes and sheep erythrocytes. Hemagglutinating activity is inhibited by smooth-type lipopolysaccharide (LPS) from S.flexneri 1A, A.salmonicida and E.coli K12, but not by rough-type LPS from S.flexneri, E.coli K12 and E.coli EH100. Agglutinates E.coli K12 and B.subtilis. | |||
TMPK-00974 |
SP17 Protein, Human, Recombinant (His)
Sperm protein 17,SPA17,CT22,Sp17-1 |
Human | E. coli |
Sperm protein 17 (Sp17) is a highly conserved mammalian protein characterized in rabbit, mouse, monkey, baboon, macaque, human testis and spermatozoa. mRNA encoding Sp17 has been detected in a range of murine and human somatic tissues. It was also recognized in two myeloma cell lines and in neoplastic cells from patients with multiple myeloma and ovarian carcinoma. SP17 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-His tag. The predicted molecular weight is 1... | |||
TMPK-01035 |
SP17 Protein, Mouse, Recombinant (His)
SPA17,Sperm protein 17,CT22,Sp17-1 |
Mouse | E. coli |
Sperm protein 17 (Sp17) is a highly conserved mammalian protein characterized in rabbit, mouse, monkey, baboon, macaque, human testis and spermatozoa. mRNA encoding Sp17 has been detected in a range of murine and human somatic tissues. It was also recognized in two myeloma cell lines and in neoplastic cells from patients with multiple myeloma and ovarian carcinoma. SP17 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-His tag. The predicted molecular weight is 1... | |||
TMPY-04964 |
Recombinant Protein A, HRP conjugate
|
||
Protein A is surface protein originally found in the cell wall of the bacteria Staphylococcusaureus. It is encoded by the spa gene and its regulation is controlled by DNA topology, cellular osmolarity, and a two component system called ArlS-ArlR. Protein A binds the Fc region of various mammalian IgG subclasses including: Human IgG1, IgG2, IgG3 (weakly), IgG4 Mouse IgG1 (weakly), IgG2a, IgG2b, IgG3 SPA also binds IgG from monkey, rabbit, pig, guinea pig, dog, rat and cat. It also weakly binds to... | |||
TMPY-03269 |
Prolyl Endopeptidase Protein, Mouse, Recombinant (His)
PEP,AI450383,AI047692,D10Wsu136e,prolyl endopeptidase,Pop |
Mouse | Baculovirus Insect Cells |
Prolyl endopeptidase, also known as PREP, belongs to a distinct class of serine peptidases. It is a large cytosolic enzyme which was first described in the cytosol of rabbit brain as an oligopeptidase. Prolyl endopeptidase degrades the nonapeptide bradykinin at the Pro-Phe bond. It is involved in the maturation and degradation of peptide hormones and neuropeptides such as alpha-melanocyte-stimulating hormone, luteinizing hormone-releasing hormone (LH-RH), thyrotropin-releasing hormone, angiotens... | |||
TMPJ-01316 |
IL-21 Protein, Mouse, Recombinant (His)
白细胞介素,IL-21,Interleukin-21,白介素,IL21 |
Mouse | E. coli |
Interleukin-21(IL-21) is an approximately 14 kDa cytokine which belongs to the IL-15/IL-21 family. Mature mouse IL-21 shares 66%,59%, 58%, and 88% aa sequence identity with mature canine, human, rabbit, and rat IL-21, respectively. IL-21 is produced by activated T follicular helper cells (Tfh), Th17 cells, and NKT cells. It exerts its biological effects through a heterodimeric receptor complex (IL-21 specific IL-21 R). IL-21 is a cytokine that has potent regulatory effects on cells of the immun... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10349 |
Apixaban 13C,d3
Apixaban 13CD3,BMS-562247-01 13CD3 |
Others | Others |
Apixaban 13CD3 (BMS-562247-01 13CD3) is a deuterium-labeled Apixaban. Apixaban is a reversible inhibitor of Factor Xa (Ki: 0.08 nM and 0.17 nM in human and rabbit). | |||
T70883 |
Moexipril-d5
|
||
Moexipril-d5 intended for use as an internal standard for the quantification of moexipril by GC- or LC-MS. Moexipril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor moexiprilat. It is converted to moexiprilat in vivo by side chain ester hydrolysis. Moexipril inhibits ACE in a cell-free assay (IC50 = 2.7 µM for the rabbit enzyme). It also inhibits phosphodiesterase 4 (IC50s = 38, 160, and 230 µM for PDE4B2, PDE4A5 and PDE4D5, respectively). Moexipril (0.1-30 mg/kg per day) ... | |||
T71402 |
Nicorandil-d4
|
||
Nicorandil-d4 is intended for use as an internal standard for the quantification of nicorandil by GC- or LC-MS. Nicorandil is an activator of sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel Kir6.2 (EC50 = ~10 µM) and a nitric oxide (NO) donor. It is selective for SUR2B/Kir6.2 over the SUR2A/Kir6.2 channel (EC50 = >500 µM). Nicorandil activates soluble guanylate cyclase in a cell-free assay and relaxes partially depolarized isolated bovine coronary artery strips (EC50 =... |