The peptide region containing residues 390-404 in Activated Protein C (APC) is essential for anticoagulant activity and is available for interaction with antibodies or with other proteins, such as the macromolecular substrates Factors Va or VIIIa. APC reg
ProteinKinase C (19-31) TFA, a peptide inhibitor of proteinkinase C (PKC), derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31) with a serine at position 25 replacing the wild-type alanine, is used as proteinkinase C substrate p
Activated Protein C (390-404), human, a peptide derived from the vitamin K-dependent serine protease, effectively suppresses the anticoagulant activity of APC[1].
Calmodulin-Dependent ProteinKinase II (290-309) is a potent CaMK antagonist with an IC50 of 52 nM for inhibiting Ca2+ calmodulin-dependent proteinkinase II.
CRP, an acute phase serum protein synthesized in response to inflammatory cytokines, produces antitumor effects in animals. The fragment CRP (174-185) (RS-83277) shows similar activity by significantly enhancing the tumoricidal activity of human monocytes
ProteinKinase C Peptide Substrate targets specific cell spacers ina manner that is dependent on second messengers and specific adaptor proteins in response to extracellular signals that activate g protein-coupled receptors, tyrosine Kinase receptors, or
ProteinKinase C (19-31), a peptide inhibitor of proteinkinase C (PKC) derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31) with a serine at position 25 replacing the wild-type alanine, is used as a proteinkinase C substrate peptide.
ProteinKinase C (19-31) TFA 是蛋白激酶 C (PKC)的抑制剂,是由 PKCa (残基 19-31) 伪底物调控域衍生而来,25 位丝氨酸取代野生型丙氨酸作为蛋白激酶 C 底物肽,用于检测蛋白激酶 C 的活性。Proteinkinase C (PKC) TFA 通过磷酸化丝氨酸和苏氨酸氨基酸残基上的羟基来调控其它蛋白的功能。
Calmodulin-Dependent ProteinKinase II (281-309) is a synthetic peptide phosphorylatable at Thr286 by PKC, inhibiting CaM kinase II with an IC50 of 80 nM.
C-Reactive Protein (CRP) 77-82 is the 77-82 fragment of the annular (ring-shaped) C-Reactive Protein, the prototypic marker of inflammation, which serves as a cardiovascular risk marker and may promote atherogenesis.