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15

抑制剂 & 化合物

1

天然产物

7

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
TP1595	Human Papillomavirus (HPV) E7 protein (49-57) Human Papillomavirus (HPV) E7 protein 49-57
	Human Papillomavirus (HPV) E7 protein (49-57) is the H-2d-restricted human papillomavirus (HPV) E749-57 epitope.
T12711	Retro-2 cycl RN 1-001	Virus Protease	Microbiology/Virology
	Retro-2 cycl 是一种抗病毒剂，是一种逆行运输抑制剂，抑制 JCPyV（IC50s：54 μM）和 HPV16 假病毒（IC50s：160 μM）。
T8350	TPCK	Proteasome	Proteases/Proteasome; Ubiquitination
	TPCK 是丝氨酸蛋白酶抑制剂，通过与 HPV-18 E7 蛋白的视网膜母细胞瘤蛋白 (RB) 结合核心发生反应，并能够消除其 RB 结合能力。将它添加到培养基内，可修饰活角质形成细胞中的 E7 蛋白。
T1583	Vorinostat MK0683,伏立诺他,suberoylanilide hydroxamic acid,SAHA	Apoptosis; Mitophagy; Virus Protease; HDAC; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology
	Vorinostat (SAHA) 是一种泛的组蛋白脱乙酰酶 (HDAC) 抑制剂 (IC50=10 nM)，对 HDAC1/2/3/6/7/11 均有抑制活性。 Vorinostat 具有抗肿瘤活性，可以诱导细胞分化，阻滞细胞周期，诱导细胞凋亡。
T4326	AG 555 Tyrphostin B46,Tyrphostin AG 555	EGFR; Reverse Transcriptase	Angiogenesis; JAK/STAT signaling; Microbiology/Virology; Tyrosine Kinase/Adaptors
	AG 555 (Tyrphostin B46)是一种选择性EGFR 的有效抑制剂，可阻断Cdk2活化。它是一种抗逆转录病毒药。
T0134	Imiquimod 咪喹莫特,R 837,IMQ,S-26308	SARS-CoV; TLR; Autophagy; HSV	Autophagy; Immunology/Inflammation; Microbiology/Virology
	Imiquimod (R 837) 是一种免疫反应修饰剂，可作为 toll 样受体7 激动剂。它有抗病毒和抗肿瘤作用，可研究外生殖器、肛周疣、癌症和 COVID-19。
T31648	Epetirimod S 30563,S-30563,S30563	Antiviral	Immunology/Inflammation
	Epetirimod (S-30563) 是一种小分子免疫调节剂，具有抗肿瘤和抗感染活性，可用于研究乳头状瘤病毒感染。
T36432	A2ti-1	Virus Protease	Microbiology/Virology
	A2ti-1 是一种具有高选择性的附件蛋白 A2/S100A10 杂四聚体（A2t）抑制剂（IC50 ： 24 μM），抑制ARV介导的Src和p38丝裂原活化蛋白激酶（MAPK）的激活。A2ti-1 可用于研究人类乳头瘤病毒 16 型（HPV16）感染。
T67786	ABI-1968 PM	Others	Others
	ABI-1968 PM 是ABI-1968的一种衍生物。ABI-1968是一种细胞凋亡刺激剂，是一种病毒复制抑制剂。ABI-1968可用于研究宫颈上皮内瘤样病变、乳头状瘤病毒感染和鳞状上皮内病变。
T36433	A2ti-2 A2ti-2	Virus Protease; Antiviral	Immunology/Inflammation; Microbiology/Virology
	A2ti-2 是一种亲和力较低且具有选择性的膜联蛋白 A2/S100A10 异四聚体 (A2t) 抑制剂（IC50 : 230 μM)。A2ti-2 具有抗病毒活性，可选择性破坏 A2 和 S100A10 之间的蛋白质相互作用，可防止人乳头瘤病毒 16 型 (HPV16) 感染。
T15172	DSHS00884 SSYA10-001	Others	Others
	DSHS00884 is a potent inhibitor of human papillomavirus E6 (IC50: 10 μM).
T28534	RH02007 CCG 40788,RH-02007,CCG40788,CCG-40788,RH 02007	Others	Others
	RH02007 is an inhibitor of the human papillomavirus (HPV) E6 oncoprotein.
T71941	Lig3	Others	Others
	Lig3 is an inhibitor against high-risk strains of human papillomavirus (HPV) E6 oncoprotein.
T76960	Verpasep caltespen	Others	Others
	Verpasep caltespen (HspE7) 是一种重组融合蛋白，来源于Mycobacterium bovis Calmette-Guérin 热休克蛋白 65 (Hsp65)，其 C 末端与HPV16 的 E7 蛋白共价连接。Verpasep caltespen 可用于人乳头瘤病毒 (HPV)引起的癌前病变和癌性病变研究。
T36858	C12 Galactosylceramide (d18:1/12:0)	Others	Others
	C12 Galactosylceramide is a bioactive sphingolipid. It inhibits IL-4 production by 53.84% in EL4 T cells when used at a concentration of 10 μM. C12 Galactosylceramide reduces the growth of human papillomavirus type 16-associated tumors in mice and reduces tumor recurrence following surgical removal or chemotherapy. It also reduces natural killer T cell activity, delays the onset of proteinuria, and improves survival in a mouse model of systemic lupus.

化合物

Human Papillomavirus (HPV) E7 protein (49-57)

Cat.No: TP1595

Synonym: Human Papillomavirus (HPV) E7 protein 49-57

Cat.No: T12711

Synonym: RN 1-001

Target: Virus Protease

Cat.No: T8350

Target: Proteasome

Cat.No: T1583

Synonym: MK0683,伏立诺他,suberoylanilide hydroxamic acid,SAHA

Target: Apoptosis, Mitophagy, Virus Protease, HDAC, Autophagy

Cat.No: T4326

Synonym: Tyrphostin B46,Tyrphostin AG 555

Target: EGFR, Reverse Transcriptase

Cat.No: T0134

Synonym: 咪喹莫特,R 837,IMQ,S-26308

Target: SARS-CoV, TLR, Autophagy, HSV

Cat.No: T31648

Synonym: S 30563,S-30563,S30563

Target: Antiviral

Cat.No: T36432

Target: Virus Protease

Cat.No: T67786

Target: Others

Cat.No: T36433

Synonym: A2ti-2

Target: Virus Protease, Antiviral

Cat.No: T15172

Synonym: SSYA10-001

Target: Others

Cat.No: T28534

Synonym: CCG 40788,RH-02007,CCG40788,CCG-40788,RH 02007

Target: Others

Cat.No: T71941

Target: Others

Verpasep caltespen

Cat.No: T76960

Target: Others

C12 Galactosylceramide (d18:1/12:0)

Cat.No: T36858

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN4417	Larixyl acetate	Others	Others
	Larixyl acetate 是一种生物活性化学物质。

天然产物

Larixyl acetate

Cat.No: TN4417

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-01466	HLA-A02:01&B2M&HPV 16 E6 (KLPQLCTEL) Tetramer Protein, Human, MHC (His & Avi) Human papillomavirus* type 16,E6,HPV16	Human	HEK293 Cells
	Human papillomavirus (HPV) 16 infection is a necessary condition for the pathogenesis and development of cervical cancer. The E6 protein is expressed by the HPV16 E6 gene and promotes malignant phenotype transformation, which is an important mechanism for the occurrence and development of cervical cancer.
TMPK-01467	HLA-A02:01&B2M&HPV 16 E6 (KLPQLCTEL) Monomer Protein, Human, MHC (His & Avi) HPV16,E6,Human papillomavirus* type 16	Human	HEK293 Cells
	Human papillomavirus (HPV) 16 infection is a necessary condition for the pathogenesis and development of cervical cancer. The E6 protein is expressed by the HPV16 E6 gene and promotes malignant phenotype transformation, which is an important mechanism for the occurrence and development of cervical cancer.
TMPH-01584	KRT7 Protein, Human, Recombinant (His & SUMO) KRT7,Keratin, type II cytoskeletal 7,Sarcolectin,Keratin-7,T...	Human	E. coli
	Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).
TMPK-00479	AGER Protein, Cynomolgus, Recombinant (His) AGER,RAGE,SCARJ1	Cynomolgus	HEK293 Cells
	The receptor for advanced glycation end products (AGER) is an oncogenic transmembranous receptor up-regulated in various human cancers. AGER promotes proliferation, migration, and inhibits apoptosis of squamous cervical cancer and might function as a tumor promoter in cervical cancer. Our study provides novel evidence for a potential role of AGER in bridging human papillomavirus (HPV)-induced inflammation and cervical cancer.
TMPY-00575	ULBP-6 Protein, Human, Recombinant (His) RAET1L,retinoic acid early transcript 1L,ULBP6	Human	HEK293 Cells
	ULBP6/RAET1L, is a polymorphic locus that expresses a functional transcript. ULBP6 had a more restricted expression profile in cell lines and primary human tissues than other NKG2D ligands, but expression was detected in several human papillomavirus-positive cervical carcinoma cell lines and was inducible on infection with human CMV. Expression of ULBP6 on target cells induced a significant increase in NK-cell killing. ULBP-6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cel...
TMPY-00190	ULBP-6 Protein, Human, Recombinant (hFc) retinoic acid early transcript 1L,RAET1L,ULBP6	Human	HEK293 Cells
	ULBP6/RAET1L, is a polymorphic locus that expresses a functional transcript. ULBP6 had a more restricted expression profile in cell lines and primary human tissues than other NKG2D ligands, but expression was detected in several human papillomavirus-positive cervical carcinoma cell lines and was inducible on infection with human CMV. Expression of ULBP6 on target cells induced a significant increase in NK-cell killing. ULBP-6 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cel...
TMPH-02301	VPS35 Protein, Human, Recombinant (His & Myc) VPS35,Vacuolar protein sorting-associated protein 35,Vesicle...	Human	E. coli
	Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of...

重组蛋白

HLA-A*02:01&B2M&HPV 16 E6 (KLPQLCTEL) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01466

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&HPV 16 E6 (KLPQLCTEL) Monomer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01467

Species: Human

Expression System: HEK293 Cells

KRT7 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01584

Species: Human

Expression System: E. coli

AGER Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00479

Species: Cynomolgus

Expression System: HEK293 Cells

ULBP-6 Protein, Human, Recombinant (His)

Cat.No: TMPY-00575

Species: Human

Expression System: HEK293 Cells

ULBP-6 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00190

Species: Human

Expression System: HEK293 Cells

VPS35 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02301

Species: Human

Expression System: E. coli

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