73
36
2
8
2
Cat. No. | Product Name | ||
---|---|---|---|
L7900 | 成骨分子库 | 317 compounds | |
317 种成骨相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L9600 | 多肽分子库 | 791 compounds | |
791 种多肽类分子,可用于多肽药物开发及信号转导通路和作用机制研究; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T61269 |
Anti-osteoporosis agent-1
|
Others | Others |
Anti-osteoporosis agent-1 (comp 4aa) 作为一种高效的复制蛋白 A(RPA) 抑制剂,表现出其IC50值仅为18 μM。 | |||
T83032 |
Anti-osteoporosis agent-7
|
Others | Others |
Anti-osteoporosis agent-7 (Compound 133) 作为一种潜在的抗骨质疏松剂,对破骨细胞的形成展示了高度的抑制效果。 | |||
T78816 |
Anti-osteoporosis agent-4
|
NF-κB | NF-κB |
Anti-osteoporosis agent-4 (Compound 11h) 在生物医学领域中表现为有效抑制原代破骨细胞的分化,减弱RANKL诱导的破骨细胞生成,并展示出强抑制作用,具有 IC50 值为358.29 nM。此外,该化合物还能抑制关键的 PI3K/AKT 和 IκBα/NF-κB 信号通路激活,表明其在防治骨质疏松症中的潜在应用价值。 | |||
T10696 |
CB2 modulator 1
|
Cannabinoid Receptor | GPCR/G Protein |
CB2 modulator 1 是一种有效的 CB2 调节剂。 可用于免疫疾病、骨质疏松症、炎症、肾缺血的研究。 | |||
T7469 |
Alendronic Acid
alendronate,阿仑膦酸 |
Others | Others |
Alendronic Acid (alendronate) 是法呢基二磷酸合酶(FDPS)抑制剂,是一种双膦酸盐。它能够抑制破骨细胞介导的骨吸收,对绝经后骨质疏松症,恶性高钙血症和 Paget 病具有疗效。 | |||
T22703 |
CYM-5520
CYM 5520 |
S1P Receptor; LPL Receptor | GPCR/G Protein |
CYM-5520 是一种选择性的变构鞘氨醇 1-磷酸受体 2 (S1PR2) 激动剂,EC50为 480 nM。它可以在 S1PR2 受体中与 S1P 结合,可用于骨质疏松症研究。 | |||
T39508 |
KY-02327
|
Others | Others |
KY-02327 是 KY-02061的一种类似物,具有代谢稳定性。KY-02327是Dishevelled (Dvl)-CXXC5相互作用抑制剂。KY-02327激活Wnt/β-catenin 途径,从而促进成骨细胞分化。 | |||
T9917 |
Denosumab
|
RANKL/RANK | NF-κB |
Denosumab 是能够结合并抑制RANKL 受体激活因子的人单克隆抗体。它具有抗癌活性,可降髋部、低椎骨以及非椎骨骨折的风险。 | |||
T1210 |
Sodium etidronate
依替膦酸钠,Didronel |
Phosphatase | Metabolism |
Sodium etidronate (Didronel) 是一种内源性 pyrophosphate 的合成治疗性 diphosphonate 类似物。作为称为 bisphosphonates 盐类药物家族的一员,etidronate disodium 与内源性 pyrophosphate 的不同之处在于其对酶水解的耐受性。该药剂吸附 hydroxyapatite 细胞并减少破骨细胞的数量,从而抑制异常骨吸收。 Etidronate 还可以直接刺激成骨细胞的骨形成。 | |||
T1850 |
Balicatib
AAE581,巴利卡替 |
Cysteine Protease | Proteases/Proteasome |
Balicatib (AAE581) 是组织蛋白酶K 抑制剂,其对组织蛋白酶K 的抑制作用是组织蛋白酶B、L 和S 的抑制性的10到100倍。 | |||
T0308 |
Etidronic acid
HEDPA,Etidronate,HEDP,羟乙磷酸 |
Apoptosis; Phosphatase; Others; HBV | Apoptosis; Metabolism; Microbiology/Virology; Others |
Etidronic acid (HEDP) 是一种影响钙代谢的二膦酸盐,抑制异位钙化并减缓骨吸收和骨转换,可应用于洗涤,水处理,化妆品和制药业。 | |||
T2334 |
Avanafil
阿伐那非,TA1790 |
PDE | Metabolism |
Avanafil (TA1790) 是一种高活性PDE-5抑制剂,IC50=5.2 nM,对PDE1,PDE6和PDE11活性较低。 | |||
T7839 |
Lasofoxifene Tartrate
CP-336156,酒石酸拉索昔芬 |
Estrogen Receptor/ERR | Endocrinology/Hormones |
Lasofoxifene Tartrate (CP-336156) 是一种非甾体类的雌激素受体选择性调节剂 (SERM)。 | |||
T21460 |
Teriparatide acetate
hPTH 1-34 (acetate salt),Parathar acetate,Forteo,醋酸立特帕肽 |
Others | Others |
Teriparatide acetate (Forteo) 是一种 PHT 激动剂,在 HEK293 细胞中的 IC50 为 2 nM。Teriparatide acetate 是一种重组形式的甲状旁腺激素。它是一种有效的合成代谢(即骨骼生长)剂,用于治疗某些形式的骨质疏松症。间歇使用特立帕肽比破骨细胞更能激活成骨细胞,从而导致骨骼整体增加。 | |||
T6374 |
Alfacalcidol
Bondiol,Etalpha,阿法骨化醇,1-hydroxy Vitamin D3,1.alpha.-Hydroxyvitamin D3,1-hydroxycholecalciferol |
Others | Others |
Alfacalcidol (Etalpha) 是一种维生素 D3 衍生物,是非选择性的维生素 D 受体活化剂,有用于骨质疏松研究的潜力。 | |||
T6739 |
Zoledronic Acid
CGP-4244,CGP42446A,唑来膦酸,Zoledronate,CGP 42446,ZOL 446,Zometa |
Apoptosis; Rho; Autophagy | Apoptosis; Autophagy; Cell Cycle/Checkpoint |
Zoledronic Acid (ZOL 446) 是一种含氮二磷酸盐,能抑制破骨细胞的分化和凋亡,具有高效的抗骨质再吸收活性,也有抗癌作用。 | |||
T21299 |
Zoledronic acid monohydrate
唑来膦酸一水合物,zoledronate,ZOL 446,CGP 42446,CGP42446A,Zoledronic acid hydrate |
Apoptosis; Others; Autophagy | Apoptosis; Autophagy; Others |
Zoledronic acid monohydrate (CGP 42446) 是一种含氮二磷酸盐,具有高效的抗骨质再吸收活性。它能抑制破骨细胞的分化和凋亡,有抗癌作用。 | |||
T20419 |
Raloxifene
Pharoxifene,雷洛昔芬,Raloxifenum,Keoxifene,LY-139481 |
Estrogen Receptor/ERR; Others | Endocrinology/Hormones; Others |
Raloxifene (LY-139481) 是一种苯并噻吩类化合物,是一种选择性雌激素受体 (estrogen receptor) 调节剂 (SERM),对骨、血脂有雌激素激动作用,对乳腺和子宫有雌激素拮抗作用。它用于乳腺癌和骨质疏松症研究。 | |||
T12846 |
SB-423562
|
CaSR | GPCR/G Protein |
SB-423562 是一种钙敏感受体 (CaSR) 拮抗剂,可用于骨质疏松症研究。 | |||
T29164 |
WY-47766
OST-766,WY47766,WY 47766 |
Proton pump | Membrane transporter/Ion channel |
WY-47766(OST-766) 是一种小分子质子泵抑制剂,可用于研究绝经期后骨质疏松。 | |||
T19501 |
Pamidronate disodium pentahydrate
|
Others | Others |
Pamidronate disodium pentahydrate 是一种骨吸收抑制剂,能够预防骨质疏松症的化合物。 | |||
T16394 |
ONO-5334
|
SARS-CoV; Cysteine Protease | Microbiology/Virology; Proteases/Proteasome |
ONO-5334 是一种具有选择性、口服活性和高效性的组织蛋白酶 K 抑制剂,具有抗 SAR-COV-2 和抗骨吸收活性,可用于研究骨质疏松症。 | |||
T1599L |
Ibandronate sodium
伊班膦酸钠,Boniva,Ibandronate sodium salt,Bondronat |
HBV; Transferase | Metabolism; Microbiology/Virology |
Ibandronate sodium (Boniva) 是一种高活性的含氮二磷酸盐,可用于骨质疏松的研究。 | |||
T6539 |
Ibandronate sodium monohydrate
Boniva monohydrate,Bondronat monohydrate,Ibandronate sodium,伊班膦酸钠单水合物,BM-210955,BM-21.0955,伊班膦酸钠一水合物,RPR-102289A |
Apoptosis; Others | Apoptosis; Others |
Ibandronate sodium monohydrate (BM-210955) 是一种高活性的含氮二磷酸盐,可用于骨质疏松。 | |||
T24182 |
ISX-1
ISX 1 |
Others | Others |
ISX-1 抑制脂肪生成并促进成骨细胞生成。 ISX-1 可用于骨质疏松症和骨质减少症的研究。 | |||
T6373 |
Alendronate sodium hydrate
G-704650,Alendronate,MK 217,Alendronate sodium trihydrate,阿仑膦酸钠,G-704650 Adronat,Fosamax |
Transferase | Metabolism |
Alendronate sodium hydrate (MK 217) 是 farnesyl diphosphate synthase 抑制剂(IC50:460 nM)。 | |||
TP1040 |
Calcitonin (salmon)
鲑降钙素,Calcitonin salmon,Salmon calcitonin |
CGRP Receptor | GPCR/G Protein; Neuroscience |
Calcitonin (salmon) 是一种阿米林和卡西宁受体的双激动剂,是一种钙调节激素,能够刺激骨的生成并能抑制骨吸收。 | |||
TP1215 |
Abaloparatide TFA
BA 058 TFA,Abaloparatide TFA (247062-33-5 free base),BIM 44058 TFA |
Others | Others |
Abaloparatide TFA (BIM 44058 TFA) 是一种甲状旁腺激素相关蛋白 (PTHrP) 类似物药物,与相关药物特立帕肽一样用于治疗骨质疏松症。 | |||
TP1040L |
Calcitonin(salmon) Acetate(47931-85-1(free base))
Salmon calcitonin |
CGRP Receptor | GPCR/G Protein; Neuroscience |
Calcitonin(salmon)Acetate (47931-85-1(free base))(Salmon calcitonin) 是一种钙调节激素,用于治疗绝经后至少 5 年的女性骨质疏松症。 | |||
T1041 |
Risedronate Sodium
NE 58095 Sodium,Risedronic Acid Sodium,利塞膦酸钠,利赛膦酸钠 |
HBV; Transferase | Metabolism; Microbiology/Virology |
Risedronate Sodium (NE 58095 Sodium) 是一种双磷酸盐,对破骨细胞介导的骨吸收具有抑制作用。 | |||
T1641 |
Strontium ranelate
Distrontium renelate,S12911,雷尼酸锶 |
Calcium Channel; CaSR | GPCR/G Protein; Membrane transporter/Ion channel; Metabolism |
Strontium ranelate (S12911) 是抗骨质疏松的药物,能够抑制骨吸收,促进骨形成,进而促使正骨平衡。它还能够激活非骨骼细胞中的钙敏感受体 (CaSR),进而促进肌醇 1,4,5-三磷酸的生成及丝裂原活化的蛋白激酶信号转导。 | |||
T67855 |
ISX-3
|
Others | Others |
ISX-3 是有效的促成骨剂和抗脂肪生成剂。ISX-3 可以增加 PPARγ 的表达。ISX-3 可用于研究骨质减少和骨质疏松症。 | |||
T21535 |
Parathyroid Hormone (1-34), bovine
|
Thyroid hormone receptor(THR) | Endocrinology/Hormones |
Parathyroid Hormone (1-34), bovine 是一种甲状旁腺激素 (PTH) 受体激动剂,是甲状旁腺激素的一部分。 Parathyroid Hormone (1-34), bovine 可用于研究骨质疏松症和甲状旁腺功能衰退。 | |||
T77567 |
BCPA
|
Others | Others |
BCPA 是一种无细胞毒性的 Pin1 调节剂。BCPA 可调节破骨细胞活化,减弱 Pin1 蛋白的减少,从而抑制 RANKL 诱导的破骨细胞发生的受体激活物。BCPA 用于研究骨质疏松。 | |||
T8436 |
Minodronic acid
Phosphonicacid,(1-hydroxy-2-imidazo(1,2-a)pyridin-3-ylethylidene)bis-,ONO-5920,YM-529 |
Apoptosis; P2X Receptor | Apoptosis; Membrane transporter/Ion channel; Neuroscience |
Minodronic acid(YM-529) 是一种 P2X2/3 受体拮抗剂, 具有抗癌活性,可直接或间接的抑制癌细胞增殖,诱导细胞凋亡。Minodronic-acid 对各种类型的癌细胞的转移具有抑制作用。Minodronic-acid 可用于研究骨质疏松。 | |||
T60554 |
Schnurri-3 inhibitor-1
|
Others | Others |
Schnurri-3 inhibitor-1 是有效的 schnurri-3 抑制剂,schnurri-3是成人骨形成的重要调节因子。在成骨细胞系 Shn3FFL 中,Schnurri-3 inhibitor-1 通过 EF1alpha 启动子抑制 Shn3 蛋白表达 (AC50= 2.09 μM)。Schnurri-3 inhibitor-1 可用于骨质疏松症相关的研究。 | |||
T111959 |
IFB-088 acetate
|
Others | Others |
IFB-088 acetate 是一种苄基胍衍生物,可用于治疗与PPP1R15A 途径相关并与蛋白质错误折叠应激相关的疾病和癌症,如tau 病、突触核蛋白病、多谷氨酰胺和多丙氨酸疾病、白质营养不良、囊性纤维化、多发性硬化症、溶酶体储存障碍、淀粉样变性疾病、炎症、代谢障碍、心血管疾病、骨质疏松症、神经系统创伤等等。 | |||
T31944 |
Glutamine monofluorophosphate
L-Glutamine monofluorophosphate,G-MFP |
Others | Others |
Glutamine monofluorophosphate is used during the fluorotherapy of osteoporosis. | |||
T25700L |
Levormeloxifene fumarate
|
Others | Others |
Levormeloxifene fumarate is an osteoporosis drug and selective estrogen receptor modulator (SERM). | |||
T28870 |
Strontium Malonate
NBS-101,NBS 101,NBS101 |
Others | Others |
Strontium Malonate, a calcium-sensing receptor agonist, is used potentially for the treatment of postmenopausal osteoporosis. | |||
T70305 |
Zoledronate trisodium hydrate
|
Others | Others |
Zoledronate trisodium is a Bone Resorption Inhibitor and Osteoporosis Therapy Adjunct | |||
T27825 |
LG190178
LG-190178,LG 190178 |
Others | Others |
LG190178, a vitamin D receptor (VDR) ligand, is a therapeutic agent used for the treatment of psoriasis, osteoporosis, and secondary hyperparathyroidism. | |||
T69778 |
iso-Dehydrozingerone
|
Others | Others |
iso-Dehydrozingerone is a novel osteoclastogenesis inhibitor, preventing ovariectomy-induced osteoporosis in ddY mice. | |||
T11914 |
LY88074 Trimethyl ether
|
Others | Others |
LY88074 Trimethyl ether is useful for inhibiting various conditions associated with estrogen deprivation syndrome, such as osteoporosis and hyperlipidemia. | |||
T31624 |
Encaleret
JIT305,JIT 305 |
Others | Others |
Encaleret( JIT-305) is an antagonist of oral calcium-sensing receptor (CaSR), it is used for the treatment of osteoporosis. | |||
T26041 |
Ranelic acid
|
Others | Others |
Ranelic acid is an organic acid capable of chelating metal cations. Strontium ranelate, the strontium salt of Ranelic acid, is utilized to treat osteoporosis and increase bone mineral density. | |||
T11913 |
LY88074 Methyl ether
|
Others | Others |
LY88074 Methyl ether is effective in inhibiting conditions associated with estrogen deprivation syndrome, such as osteoporosis and hyperlipidemia, which occur due to various estrogen-deficient states. | |||
T15749 |
LGD-2226
|
Androgen Receptor | Endocrinology/Hormones |
LGD-2226 is a selective and orally active androgen receptor modulator (EC50: 0.2 nM, Ki: 1.5 nM for the human androgen receptor). LGD-2226 can be used for muscle wasting, osteoporosis, and sexual dysfunction. | |||
T15206 |
Eldecalcitol
艾地骨化醇,ED-71,2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3 |
Others | Others |
Eldecalcitol possesses a potent inhibitory effect on bone resorption and induces a significant increase in bone mineral density. Eldecalcitol is an orally active analogue of active vitamin D. It also is used in the treatment of osteoporosis . | |||
TP1027 |
Calcitonin, eel TFA (57014-02-5 free base)
Thyrocalcitonin eel (TFA),Calcitonin, eel TFA |
||
Calcitonin,eel TFA is a thyroid hormone polypeptide that can regulate calcium homeostasis and is widely used in the study of postmenopausal osteoporosis. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T83033 |
Anti-osteoporosis agent-2
|
||
Anti-osteoporosis agent-2 (Compound 10)为抗骨质疏松剂,能抑制RANKL诱导的破骨细胞分化。 | |||
TN1124 |
Neoeriocitrin
|
AChE | Neuroscience |
Neoeriocitrin 是一种有效的乙酰胆碱酯酶抑制剂,分离于自百日草,在 MC3T3-E1 中显示出对增殖和成骨分化的活性。 | |||
T5S1172 |
Tiliroside
银椴甙,Tribuloside,银椴苷;椴树苷 |
Antioxidant | oxidation-reduction |
Tiliroside (Tribuloside) 是糖苷类黄酮,是 α-淀粉酶的非竞争性抑制剂(Ki:84.2 μM)。它抑制胃肠道中碳水化合物的消化和葡萄糖的吸收,具有抗糖尿病作用。 | |||
T3408 |
Syringin
Lilacin,Syringoside,eleutheroside-b,Methoxyconiferine,紫丁香苷 |
NOS; Autophagy | Autophagy; Immunology/Inflammation |
Syringin (eleutheroside-b) 是欧丁香中的一种苯丙素类天然产物,通过抑制自噬来防止压力超载引起的心肌肥厚,具有抗肿瘤、抗增殖、抗骨质疏松、免疫调节和血小板聚集抑制作用。 | |||
TN7036 |
N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide
(9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide,间-甲氧基苄基-亚麻酰胺,Macamide Impurity 14 |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (Macamide Impurity 14) 是一种从玛卡中分离得到的玛卡酰胺。它能够激活典型的Wnt/β‐catenin 信号通路,诱导间充质干细胞成骨分化和随后的骨形成,可用于研究骨质疏松症。 | |||
T3906 |
Epimedin A
|
Others | Others |
Epimedin A 是一种提取自草本淫羊藿中的天然化合物。 | |||
TQ0172 |
2''-O-Rhamnosylicariside II
|
Others | Others |
2''-O-Rhamnosylicariside II 是天然来源的黄酮类糖苷化合物,可能对改善绝经后骨质疏松有益处。 | |||
TN1076 |
Oleonuezhenide
|
Others | Others |
Oleonuezhenide 分离自 Fructus Ligustri Lucidi 中,具有神经保护活性。 | |||
T2O2798 |
D-(+)-Trehalose
Ergot Sugar,D-Trehalose,Mycose,D-(+)-Trehalose Anhydrous,D-海藻糖,Trehalose |
Others; Endogenous Metabolite | Metabolism; Others |
D-(+)-Trehalose (Mycose) 来源于自Saccharomyces cerevisiae,常用作食品成分和药物赋形剂。 | |||
T6S2146 |
Epimedin B
朝藿定B,Epmedin B |
Others | Others |
Epimedin B (Epmedin B) 是一种天然活性成分,来自淫羊藿,据报道其就有抗骨质疏松症的潜能。 | |||
T3130 |
Testosterone phenylpropionate
Testosterone hydrocinnamate,苯丙酸睾酮,Retandrol,Testosterone 17-phenylpropionate |
Others | Others |
Testosterone phenylpropionate (Testosterone 17-phenylpropionate) 是一种长效雄激素。d3-Testosterone phenylpropionate 可用作内标物。 | |||
T3396 |
Baohuoside I
Icariside-II,宝藿苷I,Icariin-II,宝藿苷 I |
Apoptosis; CXCR | Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation |
Baohuoside I (Icariside-II) 是从朝鲜淫羊藿中得到的一种黄酮类天然产物,是CXCR4抑制剂,抑制 CXCR4 的表达,诱导凋亡,具有抗肿瘤活性。 | |||
T7106 |
Menaquinone-4
四烯甲萘醌,Vitamin K2,Menaquinone K4 |
Others; Endogenous Metabolite | Metabolism; Others |
Menaquinone-4 (Vitamin K2) 是维生素 K 的一种,用作止血剂,有潜力用于骨质疏松的研究。 | |||
T3397 |
Epmedin C
淫羊霍定C,Baohuoside-VI,Epimedin C |
Others | Others |
Epmedin C (Baohuoside-VI) 是天然化合物,在切除卵巢的小鼠体内与雌性激素作用相似。 | |||
T6S2252 |
Sweroside
|
Others | Others |
Sweroside 是分离自Lonicera japonica 中,具有细胞保护、抗骨质疏松和保护肝脏活性。 | |||
TN7242 |
5-Hydroxyvanillin
3,4-Dihydroxy-5-methoxybenzaldehyde |
Antifungal | Microbiology/Virology |
5-Hydroxyvanillin (3,4-Dihydroxy-5-methoxybenzaldehyde) 可从籼稻中就分离得到对金黄色葡萄球菌具有抑制作用,可用于治疗和预防骨质疏松症。 | |||
T8709 |
Nandrolone phenylpropionate
Nandrolone phenpropionate,苯丙酸诺龙 |
Androgen Receptor | Endocrinology/Hormones |
Nandrolone phenylpropionate (Nandrolone phenpropionate) 是一种合成代谢类固醇,是一种 19-nortestosterone 的衍生物。它能够促进蛋白质合成,用于缓解组织分解代谢,可以用于骨质疏松症和特纳综合征的研究。 | |||
T5751 |
Tigogenin
|
Others | Others |
Tigogenin 是甾体皂甙元,普遍用于甾体类药物的合成。它能够阻碍小鼠骨髓基质细胞脂肪细胞分化,促使成骨细胞的分化。 | |||
TN6900 |
Reptoside
|
Others | Others |
Reptoside 可从杜仲和 Ajuga chamaepitys (L.) Schreb 根部和地上部分中提取,是杜仲治疗骨质疏松症的活性环烯醚萜苷之一。 | |||
TJS0856 |
Dalbergin
黄檀素,6-Hydroxy-7-Methoxy-4-Phenylcoumarin |
Others | Others |
Dalbergin (6-Hydroxy-7-Methoxy-4-Phenylcoumarin) 是一种 Dalbergia Sissoo Linn. knot wood 提取物的成分。它具有强大的抗氧化活性。 | |||
T3S0364 |
L-Arginine
L-精氨酸,L-Arg,(S)-(+)-Arginine |
IL Receptor; Endogenous Metabolite; NO Synthase | Immunology/Inflammation; Metabolism |
L-Arginine (L-Arg) 是内皮型一氧化氮合酶(eNOS) 的底物。L-Arginine 通过阳离子氨基酸转运体家族转运到血管平滑肌细胞,并被代谢成一氧化氮、多胺或 L-脯氨酸。 | |||
T2768 |
Saikosaponin A
柴胡皂苷A,柴胡皂苷 A |
NF-κB; Antibacterial; Liver X Receptor | Metabolism; Microbiology/Virology; NF-κB |
Saikosaponin A 是银柴胡中的主要活性成分,有抗炎活性,可上调 LXRα的表达。 | |||
T1549 |
Raloxifene hydrochloride
LY156758 hydrochloride,盐酸雷洛昔芬,Raloxifene HCl,LY139481 hydrochloride,Keoxifene hydrochloride,LY156758 (Keoxifene) HCl |
Estrogen Receptor/ERR; Others; MAO; Estrogen/progestogen Receptor; Autophagy | Autophagy; Endocrinology/Hormones; Metabolism; Neuroscience; Others |
Raloxifene hydrochloride (LY156758 hydrochloride) 是一种选择性且可口服的雌激素受体调节剂,用于预防绝经后妇女的骨质疏松症。它对骨骼和胆固醇代谢具有雌激素激动作用,但对乳腺和子宫组织具有完全的雌激素拮抗作用。 | |||
T7190 |
Actein
|
Apoptosis; Akt; JNK; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling |
Actein 是从升麻的根茎中分离的一种三萜糖苷,通过促进ROS/JNK 活化和钝化人膀胱癌中的AKT 途径来抑制细胞增殖,诱导自噬和凋亡。 | |||
TN5888 |
Toddaculin
|
Others | Others |
Toddaculin 是一种天然香豆素,抑制过度的破骨细胞活性并增强成骨细胞分化和矿化。它可诱导白血病细胞分化和凋亡,具有抗炎活性。 | |||
T6S2099 |
Geraniin
|
Antioxidant; TNF | Apoptosis; oxidation-reduction |
Geraniin 是一种肿瘤坏死因子α释放抑制剂,其IC50值为 43 μM,具有抗肿瘤、抗炎和抗高血糖活性。 | |||
T3673 |
Mollugin
大叶茜草素,Rubimaillin |
HER; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Mollugin (Rubimaillin) 是Rubia cordifolia L.中主要的生物活性成分。它能通过 p38-Smad 信号通路增强 BMP-2 的成骨作用。它通过抑制 TNF-α 诱导的 NF-κB 激活起抗癌疗效。 | |||
T6S1559 |
Aurantio-obtusin
|
Others | Others |
Aurantio-obtusin 是从决明子中分离出的蒽醌类化合物,具有抗炎、抗凝血、抗氧化、抗高血压的活性。它能抑制 IgE 介导的肥大细胞和过敏模型中的过敏反应,具有研究过敏相关疾病的潜力。在大鼠中,它通过内皮细胞 PI3K/AKT/ eNOS 依赖信号通路放松全身动脉,是潜在的新型血管扩张剂。 | |||
TMA0132 | Dihydrophaseic acid | Others | Others |
Dihydrophaseic acid 3'-O-b-D-glucopyranoside (D3G) can increase the proliferation and differentiation of osteoblast cells and enhance bone formation, suggests that D3G may be a good candidate for the treatment of osteoporosis. | |||
TN6568 |
Glycinol
|
||
Glycinol enhances osteogenic differentiation and attenuates the effects of age on mesenchymal stem cells, it could as a potential preventive or treatment for osteoporosis. Glycinol also has antidiuretic activity. | |||
T81761 |
Morusignin L
|
||
Morusignin L为一种表现出抗骨质疏松症效应的化学物质。 | |||
T39445 |
Korepimedoside C
Epimedin I,朝藿苷丙 |
Others | Others |
Korepimedoside C, also known as Epimedin I, is a flavonol glycoside derived from the aerial parts of Epimedium koreanum Nakai. Epimedium koreanum Nakai is a renowned Chinese herbal medicine that has been extensively studied for its potential in addressing impotence, osteoporosis, immune suppression, and cardiovascular diseases. | |||
TN1431 |
Baohuoside VII
宝藿苷,宝藿苷VII |
Others | Others |
Baohuoside aglycone possesses cardioprotective effect in prevention of ischemia/ reperfusion injury and reduce the myocardial infraction, the mechnism is due to the reduction of the injury of free radicals. Baohuoside VII in vivo exhibits significant anti | |||
TN3753 |
Dalbergioidin
|
Tyrosinase; ROS; Akt; PI3K; TGF-beta/Smad | Cytoskeletal Signaling; Immunology/Inflammation; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells |
Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces bikiniensis that has commonly been used as an indicator organism. Dalbergioidin protects MC3T3-E1 osteoblastic cells against H2O2-induced cell damage through activation of the PI3K/AKT/SMAD1 pathway, suggests that it may be useful in bone metabolism diseases, particularly osteoporosis. Dalbergioidin also ameliorates doxorubicin-induced ... | |||
TN3144 |
6,4'-Dihydroxy-7-methoxyflavanone
檀木 |
ERK; IL Receptor; Antioxidant; TNF; NF-κB; MAPK; Prostaglandin Receptor; JNK; Autophagy | Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; MAPK; NF-κB; oxidation-reduction |
6,4'-Dihydroxy-7-methoxyflavanone 是一种从 Dalbergia odorifera T. Chen (Leguminosae) 的心材中分离出来的生物活性化合物,具有抗氧化、抗炎和神经保护作用。 6,4'-二羟基-7-甲氧基黄烷酮可用于治疗破骨性骨病如骨质疏松症、类风湿性关节炎和牙周病的研究。 | |||
TN4334 |
Isotaxiresinol
|
TNF | Apoptosis |
Isotaxiresinol prevents d-GalN/LPS-induced hepatic injury by inhibiting hepatocyte apoptosis through the blocking of TNF-alpha and IFN-gamma production by activated macrophages and direct inhibition of the apoptosis induced by TNF-alpha. Isotaxiresinol ma |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-06623 |
CB2/CNR2 Protein, Human, Recombinant
CB2,CB-2,CX5 |
Human | HEK293 Cells |
Genetic variants within the CNR2 gene encoding the cannabinoid receptor CB2 are associated with osteoporosis and low bone mineral density (BMD) in case-control studies. There is a possibility that genetic variants of the CNR1 gene may produce a liability to the complication of psychotic state after abuse of methamphetamine. | |||
TMPK-00217 |
Siglec-15 Protein, Human, Recombinant (His & Avi)
Siglec15,CD33 molecule-like 3,HsT1361,CD33L3,CD33 antigen-li... |
Human | HEK293 Cells |
Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates.. | |||
TMPK-01296 |
Siglec-15 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated
CD33 molecule-like 3,CD33L3,Siglec15,SIGLEC-15,CD33 antigen-... |
Cynomolgus | HEK293 Cells |
Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates. Siglec-15 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated is expressed... | |||
TMPK-01295 |
Siglec-15 Protein, Cynomolgus, Recombinant (His & Avi)
CD33 molecule-like 3,Siglec15,CD33 antigen-like 3,HsT1361,SI... |
Cynomolgus | HEK293 Cells |
Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates. Siglec-15 Protein, Cynomolgus, Recombinant (His & Avi) is expressed in HEK293 mam... | |||
TMPK-00231 |
Siglec-15 Protein (Primary Amine Labeling), Mouse, Recombinant (His), Biotinylated
CD33 molecule-like 3,Siglec15,CD33L3,HsT1361,CD33 antigen-li... |
Mouse | HEK293 Cells |
Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates. Siglec-15 Protein (Primary Amine Labeling), Mouse, Recombinant (His), Biotinylate... | |||
TMPJ-00079 |
IL-11 Protein, Mouse, Recombinant (hFc)
IL-11,Il11,白细胞介素,白介素,Interleukin-11 |
Mouse | HEK293 Cells |
Interleukin-11(IL-11) is a secreted protein and belongs to the IL-6 superfamily. IL-11 has been demonstrated to improve platelet recovery after chemotherapy-induced thrombocytopenia, induceacute phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cellproliferation and differentiation and could be use as a therapeutic for osteoporosis. IL-11 stimulates the growth of certain lymphocytes and, in the murine model, stimulates an increase in the cortical thicknes... | |||
TMPY-03260 |
QPCT Protein, Human, Recombinant (His)
QC,GCT,glutaminyl-peptide cyclotransferase,sQC |
Human | Baculovirus Insect Cells |
Glutaminyl cyclase, also known as QPCT, can promote the N-terminal cyclization reaction of N-terminal pyroglutamate(pGlu). The pGlu formation from its glutaminyl precursor is required in the maturation of numerous bioactive peptides, while the aberrant formation of pGlu may be related to several pathological processes, such as osteoporosis and amyloidotic diseases. Glutaminyl cyclase's structure reveals an alpha/beta scaffold akin to that of two-zinc exopeptidases but with several insertions and... | |||
TMPJ-00762 |
ER alpha Protein, Human, Recombinant (His)
Estrogen Receptor,ER α,estrogen receptor α,ER-Alpha,ER alpha... |
Human | E. coli |
Estrogen Receptor is a major ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. Estrogen Receptor is composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but they also play a role in other tissues such as ... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T19305 |
Eldecalcitol-d6
|
Others | Others |
Eldecalcitol is an orally active analogue of active vitamin D used in the treatment of osteoporosis. Eldecalcitol-d6 is the deuterium labeled Eldecalcitol. | |||
TMIJ-0099 |
Minodronic acid-d4
|
||
Minodronic acid-d4 是 Minodronic acid 的氘代化合物。Minodronic acid 的 CAS 号为 180064-38-4。Minodronic acid(YM-529) 是一种 P2X2/3 受体拮抗剂, 具有抗癌活性,可直接或间接的抑制癌细胞增殖,诱导细胞凋亡。Minodronic-acid 对各种类型的癌细胞的转移具有抑制作用。Minodronic-acid 可用于研究骨质疏松。 |