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TMPJ-01013
|
VCP Protein, Human, Recombinant (His)
TER ATPase,Transitional Endoplasmic Reticulum ATPase,15S Mg(...
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Human
|
E. coli
|
|
Valosin-Containing Protein (VCP) is a nuclear protein that belongs to the AAA ATPase family. VCP is a putative ATP-binding protein involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. It is necessary for the fragmentation of Golgi stacks during mitosis and their reassembly after mitosis. VCP has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin... |
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TMPY-04420
|
TLK1 Protein, Human, Recombinant (His & GST)
KIAA0137,PKU-beta,tousled like kinase 1,PKU-β
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Human
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Baculovirus Insect Cells
|
|
Tousled-like kinase 1 (or protein kinase ubiquitous, PKU-beta/TLK1) is a serine/threonine protein kinase that is implicated in chromatin remodeling, DNA replication and mitosis. TLK1 has a function important for proper chromosome segregation and maintenance of diploid cells at mitosis in mammalian cells that could be mediated by reduced phosphorylation of histone H3 and condensation of chromosomes, although other explanations to the phenotype are possible. |
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TMPH-00770
|
2S albumin Protein, Glycine max, Recombinant (His)
2S albumin,Napin-type 2S albumin 3,GM2S-1,2S seed storage al...
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Glycine max
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P. pastoris (Yeast)
|
|
This is a 2S seed storage protein.; binds to mammalian chromatin, preventing the normal formation of the kinetochore complex in the centromere and leading to the disruption of mitosis. |
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TMPY-04558
|
NEK7 Protein, Human, Recombinant (His & GST)
NIMA-related kinase 7
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Human
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Baculovirus Insect Cells
|
|
NIMA (never in mitosis gene a)-related kinase 7, NEK7 belongs to the NIMA subfamily, NEK Ser/Thr protein kinase family, protein kinase superfamily. NEKs (NIMA-related kinases) are mammalian serine/threonine (Ser/Thr) protein kinases structurally related to Aspergillus NIMA (Never in Mitosis, gene A), which plays essential roles in mitotic signaling. NEKs share an amino-terminal catalytic domain related to NIMA, an Aspergillus kinase involved in the control of several aspects of mitosis, and dive... |
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TMPH-00769
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2S albumin Protein, Glycine max, Recombinant (His & SUMO)
2S seed storage albumin protein,Napin-type 2S albumin 3,2S a...
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Glycine max
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E. coli
|
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This is a 2S seed storage protein.; binds to mammalian chromatin, preventing the normal formation of the kinetochore complex in the centromere and leading to the disruption of mitosis. 2S albumin Protein, Glycine max, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 32.2 kDa and the accession number is P19594. |
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TMPY-03596
|
JTB Protein, Human, Recombinant (mFc)
PAR,hJT,jumping translocation breakpoint,JTB,HSPC222,HJTB
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Human
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HEK293 Cells
|
|
Jumping translocation breakpoint, also known as JTB, is a member of the JTB family. Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomal segments jumping to various telomeres. JTB is expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts. It is required for normal cytokinesis during mitosis. JTB plays a role in the regulation of cell proliferation. It may be a component of the chromosomal... |
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TMPY-04443
|
NEK3 Protein, Mouse, Recombinant (His & GST)
NIMA-related kinase 3
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Mouse
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Baculovirus Insect Cells
|
|
NEK3 (NIMA (never in mitosis gene a)-related expressed kinase 3), contains 1 protein kinase domain and is a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. Members of the NEK family of protein kinases share high amino acid homology with NIMA (never in mitosis gene a). NEK3 differs from other NimA family members in that it is not the cell cycle-regulated and is found primarily in the cytoplasm. It is activated by prolactin stimulation, leading to phosphorylatio... |
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TMPY-03672
|
Survivin Protein, Human, Recombinant
BIRC5,IAP4,API4,baculoviral IAP repeat containing 5,EPR-1
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Human
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E. coli
|
|
BIRC5, also known as Survivin and EPR-1, is a member of theIAP family. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but BIRC5 has only a single BIR domain. It is expressed cell cycle-dependently and highly expressed at mitosis. As a multitasking protein, BIRC5 has dual roles in promoting cell proliferation and preventing apoptosis. Survivin is a component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation... |
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TMPH-01350
|
FOxM1 Protein, Human, Recombinant (GST)
M-phase phosphoprotein 2,Hepatocyte nuclear factor 3 forkhea...
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Human
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E. coli
|
|
Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response. FOxM1 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 43.8 kDa and the accession number is Q08050. |
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TMPH-01642
|
MELK Protein, Human, Recombinant (His & Myc)
Protein kinase Eg3,Tyrosine-protein kinase MELK,Protein kina...
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Human
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E. coli
|
|
Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. ... |
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TMPJ-00580
|
ZWINT Protein, Human, Recombinant (His)
ZWINT,ZW10 Interactor,Zwint-1,ZW10-Interacting Protein 1
|
Human
|
E. coli
|
|
ZW10 Interactor is localized to the kinetochores from late Prophase to Anaphase and has a uniform distribution in the cytoplasm of Interphase cells. ZWINT interacts ZW10, MIS12 and NDC80 subunit of the NDC80 complex specifically during mitosis. ZWINT is a part of the MIS12 complex which is required for kinetochore formation and spindle checkpoint activity. In addition, ZWINT is required to target ZW10 to the kinetochore at prometaphase. |
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TMPY-04458
|
TRIB2 Protein, Human, Recombinant (His & GST)
TRIBBLE,tribbles pseudokinase 2,TRIB2,C5FW,FLJ57420,GS3955,T...
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Human
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Baculovirus Insect Cells
|
|
Tribbles homolog 2, also known as TRB-2, and Trib2, is a member of the protein kinase superfamily and Tribbles subfamily (Trib1, Trib2, Trib3). The identification of tribbles as regulators of signal processing systems and physiological processes, including development, together with their potential involvement in diabetes and cancer, has generated considerable interest in these proteins. Tribbles have been reported to regulate the activation of some intracellular signalling pathways with roles e... |
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TMPH-01752
|
Nestin/NES Protein, Human, Recombinant (His)
Nestin,NES
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Human
|
P. pastoris (Yeast)
|
|
Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells. Nestin/NES Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 2... |
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TMPH-02884
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CTDP1 Protein, Mouse, Recombinant (His & Myc)
Fcp1,Ctdp1,RNA polymerase II subunit A C-terminal domain pho...
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Mouse
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E. coli
|
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Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation. CTDP1 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The p... |
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TMPY-03442
|
MOB4A/MOB1B Protein, Human, Recombinant (GST)
MOB kinase activator 1B,MOBKL1A,MATS2,MOB4A
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Human
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E. coli
|
|
MST1 and MST2 are the mammalian Ste2-related protein kinases most closely related to Drosophila Hippo, a major regulator of cell proliferation and survival during development. Overexpression of MST1 or MST2 in mammalian cells is proapoptotic. MST1 and MST2 activity increase during mitosis, especially in nocodazole-arrested mitotic cells, where these kinases exhibit an increase in both abundance and activation. MST1 and MST2 also can be activated nonphysiologically by okadaic acid or H2O2. The MO... |
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TMPJ-01138
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UBE2S Protein, Human, Recombinant (GST)
UBE2S,Ubiquitin-Conjugating Enzyme E2-24 kDa,E2-EPF,E2EPF,Ub...
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Human
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E. coli
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Ubiquitin-Conjugating Enzyme E2 S (UBE2S) is a member of the Ubiquitin-Conjugating Enzyme family. UBE2S interacts with CDC20, FZR1/CDH1 and VHL. UBE2S can form a thiol ester linkage with Ubiquitin in an Ubiquitin Activating Enzyme-Dependent manner, a characteristic property of Ubiquitin Carrier Proteins. UBE2S acts as an essential factor of the Anaphase Promoting Complex/Cyclosome, a cell cycle-regulated Ubiquitin ligase that controls progression through mitosis. UBE2S is also involved in ubiqui... |
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TMPH-02205
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Titin Protein, Human, Recombinant (His)
Connectin,TTN,Rhabdomyosarcoma antigen MU-RMS-40.14,Titin
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Human
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E. coli
|
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Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to ch... |
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TMPH-01351
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FOxM1 Protein, Human, Recombinant (His & Myc & SUMO)
Forkhead-related protein FKHL16,MPM-2 reactive phosphoprotei...
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Human
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E. coli
|
|
Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response. FOxM1 Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 31.2 kDa and the accession number is Q08050. |
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TMPH-02870
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PDXP Protein, Mouse, Recombinant (His & SUMO)
Pdxp,Pyridoxal phosphate phosphatase,Chronophin,Pyridoxal 5'...
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Mouse
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E. coli
|
|
Functions as a pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP and therefore plays a role in vitamin B6 metabolism. Also functions as a protein serine phosphatase that specifically dephosphorylates 'Ser-3' in proteins of the actin-depolymerizing factor (ADF)/cofilin family like CFL1 and DSTN. Thereby, regulates cofilin-dependent actin cytoskel... |
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TMPH-01692
|
MAPK3 Protein, Human, Recombinant (His)
MAP kinase isoform p44,p44-ERK1,MAPK3,Extracellular signal-r...
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Human
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E. coli
|
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Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, c... |
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TMPH-02304
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Vasohibin-2/VASH2 Protein, Human, Recombinant (His & SUMO)
Vasohibin-2,VASH2,Vasohibin-like protein,Tubulinyl-Tyr carbo...
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Human
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E. coli
|
|
Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Critical for spindle function and accurate chromosome segregation during mitosis since microtuble detyronisation regulates mitotic spindle length and postioning. Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis. Plays a role in axon formation. Vasohibin-2/VASH2 Protein, Human,... |
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TMPY-03607
|
Cofilin Protein, Human, Recombinant (His)
CFL,HEL-S-15,cofilin 1 (non-muscle)
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Human
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E. coli
|
|
CFL1, also known as n-cofilin, is a member of the ADF/Cofilin family. This family comprises three genes: CFL1, CFL2 and DSTN (destrin). ADF/Cofilin family members bind G-actin monomers and depolymerize actin filaments through two mechanisms: severing and increasing the off-rate for actin monomers from the pointed end. Cofilin also binds with other proteins such as myosin, tropomyosin, α-actinin, gelsolin and scruin. These proteins compete with cofilin for actin binding. Сofilin also plays a... |
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TMPJ-00053
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PRL-2 Protein, Human, Recombinant (His)
HU-PP-1,Protein tyrosine phosphatase type IVA 2,OV-1,PTP4A2,...
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Human
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E. coli
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PTP4A2, also known as PRL2 or PTPCAAX2, is short for Protein tyrosine phosphatase type IVA 2. This protein exists in cell membrane, cytoplasm,endosome and membrane. PTP4A2 is often farnesylated during post-translational modification. Farnesylation is required for membrane targeting and for interaction with RABGGTB. The unfarnesylated forms are redirected to the nucleus and cytosol. It can stimulate progression from G1 into S phase during mitosis and promotes tumors. It also inhibits geranylgeran... |
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TMPY-04375
|
Casein Kinase 1 alpha Protein, Human, Recombinant (GST)
CKIa,casein kinase 1, alpha 1,casein kinase 1, α1,CK1a,Casei...
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Human
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Baculovirus Insect Cells
|
|
Casein kinase I isoform alpha, also known as CKI-alpha, CK1 and CSNK1A1, is a cytoplasm protein which belongs to theprotein kinase superfamily, CK1 Ser/Thr protein kinase family and casein kinase I subfamily. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. High expression of CSNK2A1, or concomitantly high expression of CSNK2A1, are independent prognostic factors of poor survival in NSCLC patients. CSNK2A1 are use... |
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TMPY-03105
|
Ki67/MKI67 Protein, Human, Recombinant (GST)
MIB-1,PPP1R105,marker of proliferation Ki-67,MIB-,KIA
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Human
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E. coli
|
|
MKI67 contains 1 FHA domain and plays a key role in cell proliferation. During interphase, the MKI67 antigen can be exclusively detected within the cell nucleus, whereas in mitosis most of the protein is relocated to the surface of the chromosomes. MKI67 protein is present during all active phases of the cell cycle (G1, S, G2, and mitosis), but is absent from resting cells. MKI67 is an excellent marker to determine the growth fraction of a given cell population. The fraction of MKI67-positive tu... |
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TMPJ-00769
|
TK1 Protein, Human, Recombinant (His)
cytosolic,Thymidine kinase,TK1
|
Human
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HEK293 Cells
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|
Thymidine kinase 1(TK1) belongs to the thymidine kinase family. It is located in the cytoplasm, and phosphorylated on Ser-13 in mitosis during post-translational modification. Two forms of this protein have been identified in animal cells, one in cytosol TK1 and one in mitochondria TK2. Thymidine kinases have a key function in the synthesis of DNA and thereby in cell division, as they are part of the unique reaction chain to introduce deoxythymidine into the DNA. Activity of the cytosolic enzyme... |
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TMPY-04268
|
NUDC Protein, Human, Recombinant (His)
nudC nuclear distribution protein,MNUDC,HNUDC,NPD011
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Human
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HEK293 Cells
|
|
NUDC (Nuclear Distribution C, Dynein Complex Regulator) is a Protein Coding gene. NUDC consists of at least 9 exons ranging from 66 bp to 266 bp in size and 8 introns from 92 bp to 2.0 kb in length, and the total genomic region spans about 8 kb. NUDC was mapped to 1p34-p35 by fluorescence in situ hybridization. This gene encodes a nuclear distribution protein that plays an essential role in mitosis and cytokinesis. Nuclear migration is essential for the growth, development, and cellular function... |
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TMPH-02846
|
BICD2 Protein, Mouse, Recombinant (GST)
Bicd2,Kiaa0699,Bic-D 2,Protein bicaudal D homolog 2
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Mouse
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E. coli
|
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Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (... |
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TMPY-04547
|
PBK/TOPK Protein, Human, Recombinant (His)
HEL164,Nori-3,CT84,TOPK,PDZ binding kinase,SPK
|
Human
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Baculovirus Insect Cells
|
|
PDZ binding kinase (PBK), also known as TOPK (T-LAK cell-originated protein kinase), is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family, and has all the characteristic protein kinase subdomains and a C-terminal PDZ-binding T/SXV motif. PBK is expressed in the testis restrictedly expressed in outer cell layer of seminiferous tubules, as well as placenta. PBK may be enrolled in the activation of lymphoid cells and support testicular fun... |
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TMPY-02714
|
PRC1 Protein, Human, Recombinant (His)
ASE1,protein regulator of cytokinesis 1
|
Human
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Baculovirus Insect Cells
|
|
PRC1 (protein regulator of cytokinesis 1) is a key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. It is essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. PRC1 is required for KIF14 localization to the central spindle and midbody. It is also required to recruit PLK1 to the spindle. PRC1 stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. It is a homodi... |
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TMPJ-00486
|
SUMO2 Protein, Human, Recombinant (His)
HSMT3,Ubiquitin-Like Protein SMT3A,SUMO-3,SMT3A,Sentrin-2,SM...
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Human
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E. coli
|
|
Small Ubiquitin-Related Modifier 2 (SUMO2) is an Ubiquitin-like protein that belongs to the ubiquitin family with SUMO subfamily. It is a family of small, related proteins that can be enzymatically attached to a target protein by a post-translational modification process termed sumoylation. SUMO2 can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptidebond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and l... |
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TMPY-04385
|
ZIP Kinase/DAPK3 Protein, Human, Recombinant (GST)
death-associated protein kinase 3,DLK,ZIP,ZIPK
|
Human
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Baculovirus Insect Cells
|
|
Death-associated protein kinase 3, also known as DAP kinase 3, ZIP-kinase, DAPK3 and ZIPK, is a nucleus and cytoplasm protein which belongs to theprotein kinase superfamily, CAMK Ser/Thr protein kinase family and DAP kinase subfamily. DAPK3 / ZIPK contains oneprotein kinase domain. It is a serine/threonine kinase which acts as a positive regulator of apoptosis. It phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. DAPK3 / ZIPK is a homodimer or forms heterodimers with AT... |
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TMPY-02399
|
TRF1 Protein, Human, Recombinant (His)
TRF,telomeric repeat binding factor (NIMA-interacting) 1,hTR...
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Human
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Baculovirus Insect Cells
|
|
Telomeric repeat binding factor 1 (TRF1), also known as TERF1, the shelterin complex, which modulates the telomere structures. TRF1 protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Pin2/TRF1 was originally identified as a protein bound to telomeric DNA (TRF1) and as a protein involved in mitotic regulation (Pin2). Pin2/TRF1 negatively regulates telomere length and importantly, its function is tightly regulated during the cell ... |
|
TMPY-04567
|
SRPK1 Protein, Human, Recombinant (His & GST)
SRSF protein kinase 1,SFRSK1,RP3-422H11.1
|
Human
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Baculovirus Insect Cells
|
|
Serine / threonine-protein kinase SRPK1, also known as SFRS protein kinase 1, Serine/arginine-rich protein-specific kinase 1, SR-protein-specific kinase 1 and SRPK1, is a cytoplasm and nucleus protein that belongs to the protein kinase superfamily and CMGC Ser/Thr protein kinase family. Isoform 2 of SRPK1 is predominantly expressed in the testis but is also present at lower levels in heart, ovary, small intestine, liver, kidney, pancreas and skeletal muscle. Isoform 1 of SRPK1 is only seen in th... |
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TMPY-01890
|
CLIC4 Protein, Human, Recombinant (His)
MTCLIC,chloride intracellular channel 4,p64H1,H1,huH1,CLIC4L
|
Human
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E. coli
|
|
Chloride intracellular channel protein 4, also known as Intracellular chloride ion channel protein p64H1 and CLIC4, is a member of the chloride channel CLIC family. It contains oneGST C-terminal domain. CLIC4 is a member of a family of intracellular chloride channels. It is regulated by p53, c-Myc, and tumor necrosis factor-alpha. CLIC4 is detected in epithelial cells from colon, esophagus and kidney (at protein level). CLIC4 has alternate cellular functions like a potential role in angio... |
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TMPY-04542
|
CDK2 Protein, Human, Recombinant (His)
CDKN2,cyclin-dependent kinase 2,p33(CDK2)
|
Human
|
Baculovirus Insect Cells
|
|
CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the c... |
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TMPH-02217
|
SMARCA4 Protein, Human, Recombinant (His)
Transcription activator BRG1,Protein brahma homolog 1,SWI/SN...
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Human
|
P. pastoris (Yeast)
|
|
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor compl... |
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TMPH-01267
|
RNF13 Protein, Human, Recombinant (His & Myc)
RING finger protein 8,RNF8,E3 ubiquitin-protein ligase RNF8,...
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Human
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E. coli
|
|
E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of hist... |
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