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Search Results for " arterial "

Targets Recommended: Prostaglandin Receptor PPAR

113

抑制剂 & 化合物

7

天然产物

1

化合物库

13

重组蛋白

8

同位素标记化合物

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Cat. No.	Product Name
L7110	抗高血压化合物库		678 compounds
	678 种高血压相关的小分子，用于高通量和高内涵筛选；

化合物库

抗高血压化合物库

Cat.No: L7110

Compounds: 678

Cat. No.	Product Name	Target	Signaling Pathways
T12268	NTP42	Prostaglandin Receptor; PPAR	DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Metabolism
	NTP42 是血栓素 A2 (TXA2) 受体的拮抗剂，IC50为 3.278 nM，可用于肺动脉高压的相关研究。
T11831	LDN-27219	Others	Others
	LDN-27219 是一种人组织型转谷氨酰胺酶抑制剂(IC50:600 nM)。
T11339	Furegrelate sodium U-63557A	PPAR	DNA Damage/DNA Repair; Metabolism
	Furegrelate sodium (U-63557A) 是口服有效的、血栓素合酶选择性抑制剂，抑制人血小板微粒体血栓素 A2 (TxA2) 合酶的 IC50为 15 nM。它正在开发作为抗血小板药物。
T0308	Etidronic acid HEDPA,Etidronate,HEDP,羟乙磷酸	Apoptosis; Phosphatase; Others; HBV	Apoptosis; Metabolism; Microbiology/Virology; Others
	Etidronic acid (HEDP) 是一种影响钙代谢的二膦酸盐，抑制异位钙化并减缓骨吸收和骨转换，可应用于洗涤，水处理，化妆品和制药业。
T8900	Seralutinib GB002	PDGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Seralutinib (GB002) 是可吸入的PDGFRα 和 PDGFRβ激酶抑制剂，可用于研究肺动脉高压。
T1210	Sodium etidronate 依替膦酸钠,Didronel	Phosphatase	Metabolism
	Sodium etidronate (Didronel) 是一种内源性 pyrophosphate 的合成治疗性 diphosphonate 类似物。作为称为 bisphosphonates 盐类药物家族的一员，etidronate disodium 与内源性 pyrophosphate 的不同之处在于其对酶水解的耐受性。该药剂吸附 hydroxyapatite 细胞并减少破骨细胞的数量，从而抑制异常骨吸收。 Etidronate 还可以直接刺激成骨细胞的骨形成。
T2561	Macitentan 马西替坦,ACT-064992	Apoptosis; Endothelin Receptor	Apoptosis; GPCR/G Protein
	Macitentan (ACT-064992) 是一种内皮素受体拮抗剂，用于治疗肺动脉高压。
T1613	Hydralazine hydrochloride Hydralazine HCl,Apresoline,盐酸肼屈嗪	MAO; HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism; Neuroscience
	Hydralazine hydrochloride (Apresoline) 是一种直接作用的血管舒张剂，可抗高血压。
T14782	Brilaroxazine RP5063	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Brilaroxazine (RP5063) 是一种有效的多模式多巴胺/5-HT 调节剂。 Brilaroxazine 是多巴胺 D2、D3 和 D4 受体、5-HT1A (Ki = 1.5 nM) 和 5-HT2A (Ki = 2.5 nM) 的部分激动剂，具有拮抗活性 5-HT2B 和 5-HT7 受体，Ki 分别为 0.19 nM 和 2.7 nM。 Brilaroxazine 可用于研究神经精神和神经系统疾病的认知障碍。
T5329	Trandolapril	Angiotensin-converting Enzyme (ACE)	Metabolism
	Trandolapril 是 Trandolaprilat 的前体药物。Trandolapril 是一种口服血管紧张素转换酶抑制剂，在高血压和充血性心力衰竭及心肌梗死领域有研究价值。
T3034	Eprazinone dihydrochloride Resplen,Mucitux,Eftapan,NSC 317935,盐酸依普拉酮,依普拉酮二盐酸,Eprazinone 2HCl	Others; Neurokinin receptor	GPCR/G Protein; Neuroscience; Others
	Eprazinone dihydrochloride (NSC 317935) 是一种具有镇咳和粘液溶解作用的粘液溶解剂。它是神经激肽 1 受体的配体，可改善肺功能和动脉血氧分压，可用于慢性支气管炎的研究。
T34146	Propanidid FBA 1420,Epontol,Sombrevin,Fabontal,Fabantol	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Propanidid (Sombrevin) 是一种 γ-氨基丁酸 A 型受体 (GABAA) 激动剂，也是一种可快速发挥作用的静脉注射麻醉剂,可以降低动脉血压。
T11339L	Furegrelate	PPAR	DNA Damage/DNA Repair; Metabolism
	FUREGRELATE 是一种血栓素 A2 (TxA2) 合酶抑制剂，可减缓新生仔猪肺动脉高压的发展。
T20024	cis-Tadalafil Tadalafil EP Impurity A,cis-IC-351,(6R ,12aS)-Tadalafil,(-)-Tadalafil (6R ,12aS) diastereomer	PDE	Metabolism
	cis-Tadalafil (cis-IC-351) 是一种有效的 PDE5 抑制剂，IC50 值为 0.09 μM，可用于研究动脉高压。
T26841	BMS 182874 BMS182874,BMS-182874	Endothelin Receptor	GPCR/G Protein
	BMS 182874 是一种口服有效的高选择性内皮素受体 endothelin receptor ETA 拮抗剂，对 ETA 的 IC50 值为0.150 μM，对 ETA 的 Ki 值为0.055 μM。BMS 182874 能够在大鼠高血压模型中降低 Deoxycorticosterone acetate 诱导的动脉压，可用于研究心血管疾病。
T6147	Nortadalafil Demethyl Tadalafil,去甲基他达那非	PDE	Metabolism
	Nortadalafil (Demethyl Tadalafil) 是 demethyl Tadalafil，是一种 PDE5 抑制剂。
T0317	Buflomedil hydrochloride Buflomedil HCl,Fonzylane,Loftyl,盐酸丁咯地尔,丁咯地尔盐酸盐	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Buflomedil hydrochloride (Fonzylane) 是一种血管扩张剂，可用于外周动脉疾病引发的一系列症状。
T3216	Selexipag NS-304,ACT-293987,赛乐西帕,Uptravi	Others; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Others
	Selexipag (ACT-293987) 是前列环素受体激动剂，可引起肺血管舒张，用于治疗肺动脉高压。
T0163	Nisoldipine 尼索地平,BAY-k 5552	Calcium Channel; Reactive Oxygen Species	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB
	Nisoldipine (BAY-k 5552) 是一种高效特异的L 型Cav1.2通道阻断剂，IC50=10 nM。
T13684	Equilin 7-Dehydroestrone	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Equilin (7-Dehydroestrone) 是神经营养性雌激素类固醇，具有血管扩张活性，通过 NF-κB 信号传导增加单核细胞-内皮粘附。Equilin 通过阻断Ca（2+）进入平滑肌来同样放松肠系膜动脉的阻力。
T9881	Benzoquinamide hydrochloride 3-carbamoyl-N,N-diethyl-1,3,4,6,7,11b-hexahydro-9,11-dimethoxy-2H-benzo[a]quinolizin-2-yl acetate hydrochloride	Others	Others
	Benzoquinamide hydrochloride (3-carbamoyl-N,N-diethyl-1,3,4,6,7,11b-hexahydro-9,11-dimethoxy-2H-benzo[a]quinolizin-2-yl acetate hydrochloride) 是一种止吐剂，其增加动脉内压的作用是由于增加了外周血管阻力。
TP1323	CGRP 8-37 (rat)	CGRP Receptor	GPCR/G Protein; Neuroscience
	CGRP 8-37 (rat) 是 CGRP receptor 拮抗剂，是一种可作用于大鼠的 CGRP片段，具有潜在的抗伤害作用，可诱导动脉松弛。
T3469	PCI-27483 PCI27483	Others	Others
	PCI-27483 是一种FVIIa/tissue factor 抑制剂，具有抗肿瘤的作用。
T36506	Tempone 4-Oxo-tempo	Others	Others
	Tempone 是一种氨基氧烷，具有自由基清除剂的作用，会与活性氧（ROS）发生反应。静脉注射 Tempone 可降低自发性高血压大鼠的平均动脉。
T6968	Riociguat 利奥西呱,BAY 632521	Guanylate cyclase	GPCR/G Protein
	Riociguat (BAY 632521) 是一种鸟苷酸环化酶的刺激剂，可导致血管平滑肌松弛，用于治疗严重的肺动脉高压。
TP2075L	Bombinakinin M acetate Bombinakinin M acetate(509151-65-9 free base)	Bradykinin Receptor	GPCR/G Protein
	Bombinakinin M acetate 是一种有效的缓激肽受体激动剂，对哺乳动物动脉平滑肌缓激肽受体具有高度选择性，其效力比缓激肽高约 50 倍。
T1462	Captopril SQ 14225,甲巯丙脯酸,卡托普利,SQ-14534,SA333	RAAS	Endocrinology/Hormones
	Captopril (SA333) 是一种含巯基的，具有口服活性的血管紧张素转换酶(ACE)抑制剂，IC50=0.025 μM，广泛应用于高血压和充血性心力衰竭的研究。Captopril 也是NDM-1抑制剂，IC50=7.9 μM。
T36008	Nebentan potassium YM598	Endothelin Receptor	GPCR/G Protein
	Nebentan potassium (YM598) 是一种具有口服活性和选择性的非肽类内皮素受体 (ETA receptor) 拮抗剂。Nebentan potassium 抑制肺动脉高压，可用于研究神经系统疾病和心血管疾病。
T68086	Imitrodast	Thrombin	Proteases/Proteasome
	Imitrodast是一种小分子血栓素A2合成酶（TXA2 synthase）抑制剂，可用于治疗免疫系统疾病、呼吸系统疾病和心血管疾病，可用于研究动脉血栓形成、哮喘和冠状血管痉挛。
T2753	Avasimibe PD-148515,阿伐麦布,CI-1011	P450; Acyltransferase	Metabolism
	Avasimibe (PD-148515) 是一种口服有效的酰基辅酶 A: 胆固醇酰基转移酶 (ACAT) 抑制剂，对 ACAT1和 ACAT2的 IC50分别为 24 和 9.2 µM。Avasimibe 在前列腺癌中有研究的价值。
T1655	Ambrisentan BSF-208075,BSF 208075,安倍生坦,LU 208075	Endothelin Receptor	GPCR/G Protein
	Ambrisentan (BSF 208075) 是 ET A 型受体选择性拮抗剂。
T11994	Melagatran	Thrombin	Proteases/Proteasome
	Melagatran 是一种直接作用且可口服的凝血酶抑制剂。Melagatran 专一性抑制凝血酶，但不影响凝血级联中的其他酶或纤溶酶。Melagatran不依赖内源性辅因子发挥其抗凝血酶效果，可缓解内毒素血症的有害影响。因此，Melagatran作为预防动脉闭塞的策略显示出前景。
T28643	Ex26 S1P1-IN-Ex26	S1P Receptor	GPCR/G Protein
	Ex26 (S1P1-IN-Ex26) 是一种具有选择性和高效性的 sphingosine 1-phosphate receptor 1 (S1P1) 拮抗剂，可破坏 SR-B1-S1PR1相互作用，抑制 S1P-S1PR1 信号转导。Ex26 可用于实验性自身免疫性脑脊髓炎、动脉粥样硬化和胃癌。
T29215	Zifaxaban TY 602,TY602,TY-602	Factor Xa	Metabolism
	Zifaxaban (TY-602) 是一种具有口服活性、竞争性和选择性的 Xa 因子 (FXa) 抑制剂，对人 FXa 的 IC50 为 11.1 nM。Zifaxaban 的亲和力很高，比其他丝氨酸蛋白酶高 10000 倍以上。Zifaxaban 可用于研究动脉和静脉血栓形成。
T31615	Elsibucol AGI-1096,UNII-O7T92N1Y8T,AGI 1096	Antioxidant	oxidation-reduction
	Elsibucol (AGI 1096) 是一种VCAM1抑制剂，可用于研究器官移植排斥。Elsibucol 是一种代谢稳定的丙醇衍生物，具有抗氧化、抗炎和抗增殖的特性。它能降低血液中的胆固醇水平，减少受伤动脉中的氧化应激和炎症反应，从而抑制动脉粥样硬化，保护动脉损伤后的内皮愈合。
T6264	Bosentan Actelion,波生坦,Ro 47-0203,Benzenesulfonamide	Endothelin Receptor	GPCR/G Protein
	Bosentan (Benzenesulfonamide) 是 endothelin-1 (ET)拮抗剂，在人的 SMC 细胞中，它能够作用于 ETA 受体(Ki:4.7 nM)和 ETB 受体(Ki:95 nM)。
T27624	Iptakalim Hydrochloride	Potassium Channel; AChR	Membrane transporter/Ion channel; Neuroscience
	Iptakalim hydrochloride 是一种亲脂性的对氨基化合物，是 ATP 敏感的钾通道的开放剂，也是含α4β2的烟碱乙酰胆碱受体拮抗剂。它也是一种 K(ir) 6.1/SUR2B 激活剂，可通过保护内皮功能减轻大鼠缺氧引起的肺动脉高压。
T13193	TPN171	PDE	Metabolism
	TPN171是一种有效的 PDE5抑制剂，对 PDE5具有亚纳摩尔效价，对 PDE5比对 PDE6具有良好的选择性，具有治疗肺动脉高压(PAH)的潜力。在动物模型中，TPN171被证明具有比西地那非更持久的作用，为临床使用每日一次口服提供了基础。
T1215	Nicardipine hydrochloride 盐酸尼卡地平,RS-69216,Nicardipine HCl,YC-93 Hydrochloride	Calcium Channel; Adrenergic Receptor; AChR; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Nicardipine hydrochloride (YC-93 Hydrochloride) 是一种钙通道阻滞剂，IC50为 1 μM。它可阻断某些细胞壁中的钙离子并抑制冠状动脉和外周动脉的收缩，从而降低对氧气的需求心肌和减少动脉收缩和痉挛。它在临床上用作脑和冠状血管扩张剂。
T0075	Nicorandil SG-75,尼可地尔	Potassium Channel	Membrane transporter/Ion channel
	Nicorandil (SG-75) 是一种有效的钾通道激活剂，靶向血管核苷二磷酸依赖性 K+通道和心脏 ATP 敏感 K+通道 (KATP)。Nicorandil 是一种烟酰胺酯，具有血管舒张和心脏保护作用，并具有治疗心绞痛和缺血性心脏病的潜力。
T13604	CDDO-dhTFEA	Others; NF-κB; Nrf2	Immunology/Inflammation; NF-κB; Others
	CDDO-dhTFEA 是合成的齐墩果烷三萜化合物，可有效激活Nrf2并抑制促炎转录因子NF-κB。它可以恢复高血压 (MAP)，提高 Nrf2 及其靶基因的表达，抑制 NF-κB 的活化和转化生长因子-β 途径，并减少慢性肾病 (CKD) 大鼠的肾小球硬化，间质纤维化和炎症。
T37299	L-Palmitoylcarnitine chloride Palmitoyl-L-carnitine chloride	ATPase	Membrane transporter/Ion channel
	L-Palmitoylcarnitine chloride (Palmitoyl-L-carnitine chloride)是一种脂肪酸代谢产物，具有抗血栓形成的作用，通过抵消tMCAO模型中的脑内血栓形成来保护小鼠免受缺血性中风。L-Palmitoylcarnitine chloride抑制心脏中的Na/K泵，抑制 FeCl 3诱导的动脉血栓形成，减轻了短暂性大脑中动脉闭塞（tMCAO）小鼠模型的脑内血栓形成和炎症。
T0871	Noradrenaline bitartrate	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Noradrenaline bitartrate 直接作用于 α 和 β 肾上腺素能受体。它是去甲肾上腺素的酒石酸氢盐，去甲肾上腺素是一种合成苯乙胺，可模拟内源性去甲肾上腺素的拟交感神经作用。临床上，去甲肾上腺素用作外周血管收缩剂，通过其α-肾上腺素能作用导致动脉和静脉床收缩。它还被用作通过其 β-1 肾上腺素能作用介导的强效正性肌力和变时性心脏刺激剂。
TP1369L	[Sar9,Met(O2)11]-Substance P acetate [Sar9,Met(O2)11]-Substance P acetate(110880-55-2 free base)	Neurokinin receptor	GPCR/G Protein; Neuroscience
	[Sar9,Met(O2)11]-Substance P acetate(110880-55-2 free base) 是一种速激肽 NK1 受体选择性激动剂。它是一种选择性速激肽 NK1 受体激动剂。它和 septide（每只大鼠 10-100 pmol，i.c.v.）在增加平均动脉血压 (MAP) 和心率 (HR)，但它们的时间进程不同。两种激动剂都以剂量依赖性方式增加洗脸和吸鼻，而它是一种产生美容效果的化合物。
T24760	Satigrel E 5510,E5510	Others	Others
	Satigrel is a new antiplatelet agent. It also inhibits platelet accumulation in prosthetic arterial grafts.
T19660	QCC-374 QCC374	Others	Others
	QCC-374 is a prostanoid agonist. It potentially for the treatment of pulmonary arterial hypertension.
T70681	G-4120	Others	Others
	G-4120 is a biochemical that has been shown to have a dose-dependent complete inhibition of arterial and venous thrombosis.
T30501	BMS-193884 BMS193884,BMS 193884	Others	Others
	BMS-193884 is an oral endothelin antagonist for the treatment of congestive heart failure (CHF) and pulmonary arterial hypertension.
T27930	LY-127210 free base LY 127210,LY127210	Others	Others
	LY-127210 free base is peripheral arterial vasodilator with antihypertensive activity.
T29200	Z-335 sodium Z 335,Z335,Z-335	Others	Others
	Z-335 Salt, a thromboxane A2 receptor antagonist, is used potentially for the treatment of arterial occlusive disease.

化合物

Cat.No: T12268

Target: Prostaglandin Receptor, PPAR

Cat.No: T11831

Target: Others

Furegrelate sodium

Cat.No: T11339

Synonym: U-63557A

Target: PPAR

Cat.No: T0308

Synonym: HEDPA,Etidronate,HEDP,羟乙磷酸

Target: Apoptosis, Phosphatase, Others, HBV

Cat.No: T8900

Synonym: GB002

Target: PDGFR

Sodium etidronate

Cat.No: T1210

Synonym: 依替膦酸钠,Didronel

Target: Phosphatase

Cat.No: T2561

Synonym: 马西替坦,ACT-064992

Target: Apoptosis, Endothelin Receptor

Hydralazine hydrochloride

Cat.No: T1613

Synonym: Hydralazine HCl,Apresoline,盐酸肼屈嗪

Target: MAO, HIF/HIF Prolyl-Hydroxylase

Cat.No: T14782

Synonym: RP5063

Target: Dopamine Receptor, 5-HT Receptor

Cat.No: T5329

Target: Angiotensin-converting Enzyme (ACE)

Eprazinone dihydrochloride

Cat.No: T3034

Synonym: Resplen,Mucitux,Eftapan,NSC 317935,盐酸依普拉酮,依普拉酮二盐酸,Eprazinone 2HCl

Target: Others, Neurokinin receptor

Cat.No: T34146

Synonym: FBA 1420,Epontol,Sombrevin,Fabontal,Fabantol

Target: GABA Receptor

Cat.No: T11339L

Target: PPAR

Cat.No: T20024

Synonym: Tadalafil EP Impurity A,cis-IC-351,(6R ,12aS)-Tadalafil,(-)-Tadalafil (6R ,12aS) diastereomer

Target: PDE

Cat.No: T26841

Synonym: BMS182874,BMS-182874

Target: Endothelin Receptor

Cat.No: T6147

Synonym: Demethyl Tadalafil,去甲基他达那非

Target: PDE

Buflomedil hydrochloride

Cat.No: T0317

Synonym: Buflomedil HCl,Fonzylane,Loftyl,盐酸丁咯地尔,丁咯地尔盐酸盐

Target: Adrenergic Receptor

Cat.No: T3216

Synonym: NS-304,ACT-293987,赛乐西帕,Uptravi

Target: Others, Prostaglandin Receptor

Cat.No: T0163

Synonym: 尼索地平,BAY-k 5552

Target: Calcium Channel, Reactive Oxygen Species

Cat.No: T13684

Synonym: 7-Dehydroestrone

Target: Calcium Channel

Benzoquinamide hydrochloride

Cat.No: T9881

Synonym: 3-carbamoyl-N,N-diethyl-1,3,4,6,7,11b-hexahydro-9,11-dimethoxy-2H-benzo[a]quinolizin-2-yl acetate hydrochloride

Target: Others

CGRP 8-37 (rat)

Cat.No: TP1323

Target: CGRP Receptor

Cat.No: T3469

Synonym: PCI27483

Target: Others

Cat.No: T36506

Synonym: 4-Oxo-tempo

Target: Others

Cat.No: T6968

Synonym: 利奥西呱,BAY 632521

Target: Guanylate cyclase

Bombinakinin M acetate

Cat.No: TP2075L

Synonym: Bombinakinin M acetate(509151-65-9 free base)

Target: Bradykinin Receptor

Cat.No: T1462

Synonym: SQ 14225,甲巯丙脯酸,卡托普利,SQ-14534,SA333

Target: RAAS

Nebentan potassium

Cat.No: T36008

Synonym: YM598

Target: Endothelin Receptor

Cat.No: T68086

Target: Thrombin

Cat.No: T2753

Synonym: PD-148515,阿伐麦布,CI-1011

Target: P450, Acyltransferase

Cat.No: T1655

Synonym: BSF-208075,BSF 208075,安倍生坦,LU 208075

Target: Endothelin Receptor

Cat.No: T11994

Target: Thrombin

Cat.No: T28643

Synonym: S1P1-IN-Ex26

Target: S1P Receptor

Cat.No: T29215

Synonym: TY 602,TY602,TY-602

Target: Factor Xa

Cat.No: T31615

Synonym: AGI-1096,UNII-O7T92N1Y8T,AGI 1096

Target: Antioxidant

Cat.No: T6264

Synonym: Actelion,波生坦,Ro 47-0203,Benzenesulfonamide

Target: Endothelin Receptor

Iptakalim Hydrochloride

Cat.No: T27624

Target: Potassium Channel, AChR

Cat.No: T13193

Target: PDE

Nicardipine hydrochloride

Cat.No: T1215

Synonym: 盐酸尼卡地平,RS-69216,Nicardipine HCl,YC-93 Hydrochloride

Target: Calcium Channel, Adrenergic Receptor, AChR, Autophagy

Cat.No: T0075

Synonym: SG-75,尼可地尔

Target: Potassium Channel

Cat.No: T13604

Target: Others, NF-κB, Nrf2

L-Palmitoylcarnitine chloride

Cat.No: T37299

Synonym: Palmitoyl-L-carnitine chloride

Target: ATPase

Noradrenaline bitartrate

Cat.No: T0871

Target: Adrenergic Receptor

[Sar9,Met(O2)11]-Substance P acetate

Cat.No: TP1369L

Synonym: [Sar9,Met(O2)11]-Substance P acetate(110880-55-2 free base)

Target: Neurokinin receptor

Cat.No: T24760

Synonym: E 5510,E5510

Target: Others

Cat.No: T19660

Synonym: QCC374

Target: Others

Cat.No: T70681

Target: Others

Cat.No: T30501

Synonym: BMS193884,BMS 193884

Target: Others

LY-127210 free base

Cat.No: T27930

Synonym: LY 127210,LY127210

Target: Others

Cat.No: T29200

Synonym: Z 335,Z335,Z-335

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T4454	Traumatic Acid Dodec-2-Enedioic Acid,2E-Dodecenedioic Acid,愈伤酸,Trans-2-Dodecenedioic Acid	Antioxidant	oxidation-reduction
	Traumatic Acid (Dodec-2-Enedioic Acid) 是一种单不饱和二元羧酸，从菜豆中分离得到。它可减少膜磷脂的过氧化，并表现出抗氧化和对胶原生物合成的刺激作用。它可用于许多与胶原蛋白生物合成障碍和氧化应激有关的皮肤疾病的研究。
T3S2007	MRE-269 3-氧代-12-烯-28-乌苏酸,MRE 269,ACT-333679,MRE269	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	MRE-269 (ACT-333679) 是一种口服的长效前列环素受体激动剂前药，是 Selexipag 的活性代谢物，用于治疗肺动脉高压。
T5074	Cholesteryl palmitate	Others; Endogenous Metabolite	Metabolism; Others
	Cholesteryl palmitate 是一种慢性间质性肺炎的有用预后生物标志物。
TN1343	8-Geranyloxypsoralen 8-香叶草氧基补骨脂素	Anti-infection; P450; BACE	Metabolism; Microbiology/Virology; Neuroscience
	8-Geranyloxypsoralen 是一种呋喃香豆素，分离自葡萄柚，是 P450 3A4 的有效抑制剂(IC50:3.93 μM)。
T4776	Glycerol Glycerin,甘油	Endogenous Metabolite	Metabolism
	Glycerol 是甘油三酯（即脂肪和油）和磷脂的重要成分。它在食品工业中被广泛用作甜味剂和保湿剂以及药物制剂。
TN1953	Morusinol 桑根皮醇,桑树醇	ERK; MEK; Autophagy; Ras	Autophagy; GPCR/G Protein; MAPK
	Morusinol 是从桑树根皮中提取出的类黄酮。 Morusinol 具有抗血小板和抗癌活性，在体内抑制动脉血栓形成，通过诱导自噬、G2/M 细胞周期阻滞、抑制细胞侵袭和迁移以及靶向 Ras/MEK/ERK 通路发挥抗肿瘤活性。
T35624	Ajoene	Others	Others
	Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs = 5-160 &#181g/ml) and Gram-negative bacteria (MICs = 136-200 &#181g/ml), as well as yeasts (MICs = 10-20 &#181g/ml).1Ajoene is cytotoxic to mouse melanoma cells (IC50= 18 &#181M), as well as human colon, lung, mammary, and pancreatic cancer cells (IC50s = 7-41 &#181M).2It reduces...

天然产物

Cat.No: T4454

Synonym: Dodec-2-Enedioic Acid,2E-Dodecenedioic Acid,愈伤酸,Trans-2-Dodecenedioic Acid

Target: Antioxidant

Cat.No: T3S2007

Synonym: 3-氧代-12-烯-28-乌苏酸,MRE 269,ACT-333679,MRE269

Target: Prostaglandin Receptor

Cholesteryl palmitate

Cat.No: T5074

Target: Others, Endogenous Metabolite

8-Geranyloxypsoralen

Cat.No: TN1343

Synonym: 8-香叶草氧基补骨脂素

Target: Anti-infection, P450, BACE

Cat.No: T4776

Synonym: Glycerin,甘油

Target: Endogenous Metabolite

Cat.No: TN1953

Synonym: 桑根皮醇,桑树醇

Target: ERK, MEK, Autophagy, Ras

Cat.No: T35624

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01210	IL-33 Protein, Mouse, Recombinant Interleukin-1 family member 11,白细胞介素,NF-HEV and IL- 1F11,白介素...	Mouse	E. coli
	Mouse Interleukin 33 (IL-33) is a 30 kDa proinflammatory cytokine which may also regulates gene transcription in producer cells. IL-33 is constitutively expressed in smooth muscle and airway epithelia. IL-33 was identified based on sequence and structural homology with IL-1 family cytokines. It is up‑regulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL-1 alpha or IL‑1 beta stimulation. IL-33 is structurally related to IL-1, which induces helper T cells to produ...
TMPH-02636	Elastin Protein, Mouse, Recombinant (His) Elastin,Tropoelastin,Eln	Mouse	E. coli
	Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle. Elastin Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 21.3 kDa and the accession number is P54320.
TMPJ-00572	Vasorin Protein, Human, Recombinant (His) Vasorin,VASN,SLITL2,Protein Slit-Like 2	Human	HEK293 Cells
	Vasorin is a Type I membrane protein, which is predominantly expressed in vascular smooth muscle cells in a developmentally regulated pattern. The expression level of Vasorin can be down regulated during vessel repair after arterial injury. Vasorin binds to transforming growth factor beta (TGF-β) and attenuates TGF-β signaling in vitro.
TMPJ-00741	PTH Protein, Human, Recombinant (His) Parathyroid hormone,Parathyrin,PTH,Parathormone	Human	HEK293 Cells
	Parathyroid hormone (PTH) is a critical hormone in the regulation of Ca++ homeostasis. Parathyroid hormone is the most important endocrine regulator of calcium and phosphorus concentration in extracellular fluid. This hormone is secreted from cells of the parathyroid glands and finds its major target cells in bone and kidney. Another hormone, parathyroid hormone-related protein, binds to the same receptor as parathyroid hormone and has major effects on development. Like most other protein hormon...
TMPH-00780	CACNA1C Protein, Guinea Pig, Recombinant (His) CACNA1C,CACNL1A1,CACH2,CACN2,Voltage-dependent L-type calciu...	Guinea pig	E. coli
	Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressur...
TMPJ-01129	SMAD1 Protein, Human, Recombinant (GST) hSMAD1,Transforming Growth Factor-Beta-Signaling Protein 1,T...	Human	E. coli
	SMAD Family Member 1 (SMAD1) is a member of the dwarfin/SMAD family. SMAD1 has the highest expression in the heart and skeletal muscle, containing one MAD homology 1 domain and one MAD homology 2 domain, As a transcriptional modulator SMAD 1 is activated by bone morphogenetic proteins type 1 receptor kinase. Defects in SMAD1 may cause primary pulmonary hypertension (PPH1), characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated ...
TMPJ-01061	Nucleobindin-2 Protein, Human, Recombinant NUCB2,NEFA,Gastric cancer antigen Zg4,Nesfatin-1,Prepronesfa...	Human	E. coli
	Nesfatin-1 is a metabolic polypeptide encoded in the N-terminal region of the precursor protein, Nucleobindin2 (NUCB2). Nesfatin-1 is a neuropeptide produced in the hypothalamus of mammals. It participates in the regulation of hunger and fat storage. Nesfatin-1 is also expressed in other areas of the brain, and in pancreatic islets β-cells, gastric endocrine cells and adipocytes. Nesfatin-1 suppresses food intake and can regulate energy metabolism in a Leptin independent manner. Nesfatin-1 may ...
TMPH-01297	DDR1 Protein, Human, Recombinant (aa 21-417, His) EDDR1,MCK-10,Epithelial discoidin domain-containing receptor...	Human	HEK293 Cells
	Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell...
TMPJ-00253	OPG Protein, Mouse, Recombinant (His) Opg,Ocif,Tnfrsf11b,Osteoclastogenesis inhibitory factor,Oste...	Mouse	HEK293 Cells
	Osteoprotegerin (OPG, Tnfrsf11b) is a secreted protein that regulates bone density. OPG is widely expressed and constitutively released as a homodimer by mesenchymal stem cells, fibroblasts and endothelial cells. Regulation of its expression by estrogen, parathyroid hormone and cytokines is complex and changes with age. OPG acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TRAIL decreases the release of OPG from cells that express it, while OPG ...
TMPY-04471	APEG1 Protein, Human, Recombinant (His) SPEG complex locus,BPEG,SPEGalpha,SPEGβ,APEG-1,SPEGbeta,APEG...	Human	E. coli
	Striated muscle preferentially expressed protein kinase, also known as aortic preferentially expressed protein 1, APEG-1, SPEG and KIAA1297, is a protein that belongs to the protein kinase superfamily and CAMK Ser/Thr protein kinase family. SPEG / APEG-1 contains two fibronectin type-III domains, nine Ig-like (immunoglobulin-like) domains, two protein kinase domains. Isoform 1 of SPEG is preferentially expressed in striated muscle. Non-kinase form such as isoform 3 of SPEG is predominantly expre...
TMPY-02172	Midkine Protein, Human, Recombinant midkine (neurite growth-promoting factor 2),NEGF2,MK,ARAP	Human	Baculovirus Insect Cells
	Midkine (MK or MDK) also known as neurite growth-promoting factor 2 (NEGF2) is a basic heparin-binding growth factor of low molecular weight, and forms a family with pleiotrophin. Midkine is a retinoic acid-responsive, heparin-binding growth factor expressed in various cell types during embryogenesis. It promotes angiogenesis, cell growth, and cell migration. Midkine is also expressed in several carcinomas, suggesting that it may play a role in tumorigenesis, perhaps through its effects on angio...
TMPY-01027	Mast Cell Protease-1/MCPT-1 Protein, Mouse, Recombinant (His) carnitine palmitoyltransferase 1B (muscle),AV080368,Mcp-1	Mouse	HEK293 Cells
	Mast Cell Protease 1 (MMCP-1), also known as MCP-1, MCPT-1 and β-chymase, is a member of the Chymase family of chymotrypsin-like serine proteases. MCPT-1 is a 26 kDa β-chymase that is a component of mast cell granules. It is a 226 amino acid (aa) protein that has a conserved pattern of six cysteines and one potential glycosylation site. The granule-derived mouse mast cell proteases-1 and -2 (mMCP-1 and -2) colocalize in similar quantities in mucosal mast cells but micrograms of mMCP-1 compared w...
TMPH-02841	Prohibitin Protein, Mouse, Recombinant (His) Phb1,B-cell receptor-associated protein 32,Prohibitin 1	Mouse	E. coli
	Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus. Plays a role in adipose tissue and glucose Homeostasis in a sex-specific manner. Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells.; In the mitochondria, together with...

重组蛋白

IL-33 Protein, Mouse, Recombinant

Cat.No: TMPJ-01210

Species: Mouse

Expression System: E. coli

Elastin Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02636

Species: Mouse

Expression System: E. coli

Vasorin Protein, Human, Recombinant (His)

Cat.No: TMPJ-00572

Species: Human

Expression System: HEK293 Cells

PTH Protein, Human, Recombinant (His)

Cat.No: TMPJ-00741

Species: Human

Expression System: HEK293 Cells

CACNA1C Protein, Guinea Pig, Recombinant (His)

Cat.No: TMPH-00780

Species: Guinea pig

Expression System: E. coli

SMAD1 Protein, Human, Recombinant (GST)

Cat.No: TMPJ-01129

Species: Human

Expression System: E. coli

Nucleobindin-2 Protein, Human, Recombinant

Cat.No: TMPJ-01061

Species: Human

Expression System: E. coli

DDR1 Protein, Human, Recombinant (aa 21-417, His)

Cat.No: TMPH-01297

Species: Human

Expression System: HEK293 Cells

OPG Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00253

Species: Mouse

Expression System: HEK293 Cells

APEG1 Protein, Human, Recombinant (His)

Cat.No: TMPY-04471

Species: Human

Expression System: E. coli

Midkine Protein, Human, Recombinant

Cat.No: TMPY-02172

Species: Human

Expression System: Baculovirus Insect Cells

Mast Cell Protease-1/MCPT-1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01027

Species: Mouse

Expression System: HEK293 Cells

Prohibitin Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02841

Species: Mouse

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMID-0210	Sildenafil-13C-d3
	Sildenafil-13C-d3 是 Sildenafil 的 13C 和氘代化合物。Sildenafil 的 CAS 号为 139755-83-2。Sildenafil 是一种磷酸二酯酶 5 抑制剂，IC50为 5.22 nM。
TMID-0043	Sildenafil-d8
	Sildenafil-d8 是 Sildenafil 的氘代化合物。Sildenafil 的 CAS 号为 139755-83-2。Sildenafil 是一种磷酸二酯酶 5 抑制剂，IC50为 5.22 nM。
TMIH-0520	Selexipag-d7
	Selexipag-d7 是 Selexipag 的氘代化合物。Selexipag 的 CAS 号为 475086-01-2。Selexipag 是前列环素受体激动剂，可引起肺血管舒张，用于治疗肺动脉高压。
TMIH-0497	Riociguat-13C-d6
	Riociguat-13C-d6 是 Riociguat 的 13C 和氘代化合物。Riociguat 的 CAS 号为 625115-55-1。Riociguat 是一种鸟苷酸环化酶的刺激剂，可导致血管平滑肌松弛，用于治疗严重的肺动脉高压。
TMIH-0519	Selexipag Active Metabolite-d7
	Selexipag Active Metabolite-d7 是 Selexipag Active Metabolite 的氘代化合物。Selexipag Active Metabolite 的 CAS 号为 475085-57-5。MRE269 是一种口服的长效前列环素受体激动剂前药，是 Selexipag 的活性代谢物，用于治疗肺动脉高压。
T71065	Quinapril-d5
	Quinapril-d5 is intended for use as an internal standard for the quantification of quinapril by GC- or LC-MS. Quinapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor quinaprilat. In vivo, quinapril reduces mean arterial pressure in renal hypertensive and spontaneously hypertensive rats. It inhibits angiotensin I-induced pressor responses in normotensive rats and dogs. Quinapril prevents left ventricular heart failure in CHF 14.6 cardiomyopathic hamsters. Formulations con...
T71981	Gliclazide-d4
	Gliclazide-d4 is intended for use as an internal standard for the quantification of gliclazide by GC- or LC-MS. Gliclazide is a sulfonylurea and an inhibitor of pancreatic β-cell ATP-sensitive potassium (KATP) channels. It is selective for pancreatic β-cell over cardiac and arterial smooth muscle cell KATP channels. Gliclazide (5 μM) increases insulin-induced glucose uptake and glucose transporter 4 (GLUT4) translocation to the plasma membrane in a differentiated 3T3L1 adipocyte model of insulin...
TMID-0040	Palmitoyl L-Carnitine-d3 Hydrochloride
	Palmitoyl L-Carnitine-d3 Hydrochloride 是 Palmitoyl L-Carnitine Hydrochloride 的氘代化合物。Palmitoyl L-Carnitine Hydrochloride 的 CAS 号为 18877-64-0。L-Palmitoylcarnitine chloride (Palmitoyl-L-carnitine chloride)是一种脂肪酸代谢产物，具有抗血栓形成的作用，通过抵消tMCAO模型中的脑内血栓形成来保护小鼠免受缺血性中风。L-Palmitoylcarnitine chloride抑制心脏中的Na/K泵，抑制 FeCl 3诱导的动脉血栓形成，减轻了短暂性大脑中动脉闭塞（tMCAO）小鼠模型的脑内血栓形成和炎症。

同位素标记化合物

Sildenafil-13C-d3

Cat.No: TMID-0210

Cat.No: TMID-0043

Cat.No: TMIH-0520

Riociguat-13C-d6

Cat.No: TMIH-0497

Selexipag Active Metabolite-d7

Cat.No: TMIH-0519

Cat.No: T71065

Cat.No: T71981

Palmitoyl L-Carnitine-d3 Hydrochloride

Cat.No: TMID-0040

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