102
3
1
3
Cat. No. | Product Name | ||
---|---|---|---|
L1110 | 微管靶向化合物库 | 142 compounds | |
142 种靶向微管的分子集合,用于高通量筛选和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13278 |
Valecobulin hydrochloride
CKD-516 hydrochloride |
Microtubule Associated | Cytoskeletal Signaling |
Valecobulin hydrochloride (CKD-516 hydrochloride) 是 S516 的缬氨酸前体药和血管阻断剂。Valecobulin hydrochloride 对β-微管蛋白聚合有强效的抑制作用,对小鼠和人类的实体肿瘤具有显著的抗肿瘤活性。 | |||
T10460 |
Batabulin
巴他布林,T138067 |
Apoptosis; Microtubule Associated | Apoptosis; Cytoskeletal Signaling |
Batabulin (T138067) 是一种抗肿瘤剂,可与 β-微管蛋白同种型的子集共价且选择性地结合,从而破坏微管聚合。它影响细胞形态并导致细胞周期停滞,最终诱导细胞凋亡。 | |||
T78701 |
Tubulin inhibitor 32
|
Apoptosis | Apoptosis |
Tubulin inhibitor 32是一种口服活性的新型微管抑制剂,具有抗增殖和抗肿瘤活性,可抑制微管聚合,可诱导细胞凋亡及在G2/M期引起细胞周期停滞。 | |||
T77584 |
Tubulin inhibitor 35
Tubulin IN 35 |
Apoptosis; Microtubule Associated; Topoisomerase | Apoptosis; Cytoskeletal Signaling; DNA Damage/DNA Repair |
Tubulin inhibitor 35 (Tubulin IN 35) 是一种有效的拓扑异构酶 I 和微管蛋白聚合 的双重抑制剂,具有抗肿瘤活性,对 MGC-803 和 RKO 细胞株的迁移和侵袭有抑制作用,中断细胞周期,诱导凋亡 (apoptosis)。 | |||
T67935 |
Tubulin inhibitor 11
|
Apoptosis; Microtubule Associated | Apoptosis; Cytoskeletal Signaling |
Tubulin inhibitor 11 是一种口服活性的有效微管蛋白抑制剂。它通过靶向秋水仙碱结合位点,抑制tubulin聚合,进而促进有丝分裂阻断和apoptosis。 | |||
T9812 |
Tubulin inhibitor 24
|
Microtubule Associated | Cytoskeletal Signaling |
Tubulin inhibitor 24 是一种 tubulin 抑制剂,可以抑制微管蛋白聚合,以浓度依赖性方式诱导细胞周期停滞在 G2/M 期, 具有抗肿瘤活性且无明显毒性。 | |||
T77728 |
Tubulin polymerization-IN-55
|
Microtubule Associated | Cytoskeletal Signaling |
Tubulin polymerization-IN-55 是一种高效的 Tubulin Polymerization 抑制剂,具有潜在的抗血管生成和抗肿瘤活性,对 A549、K562、HepG2、MDA-MB-231 和 HFL-1 显示出抗增殖作用。 | |||
T13224 |
Tubulin inhibitor 6
iHAP1 |
Microtubule Associated | Cytoskeletal Signaling |
Tubulin inhibitor 6 (iHAP1) 是一种微管蛋白抑制剂,抑制微管蛋白聚合,IC50为 0.87 μM。它抑制多种癌细胞系,抑制 K562 细胞生长,IC50为 840 nM。 | |||
T77647 |
Tubulin polymerization-IN-43
|
Apoptosis; Microtubule Associated | Apoptosis; Cytoskeletal Signaling |
Tubulin polymerization-IN-43 是一种微管蛋白聚合 (tubulin polymerization) 抑制剂。Tubulin polymerization-IN-43 具有多种作用,通过靶向 Colchicine 位点破坏细胞微管网络,促进白血病细胞的细胞周期停滞在 G2/M 期和细胞凋亡 (apoptosis)。Tubulin polymerization-IN-43 具有抗血管生成活性。 | |||
T77651 |
Tubulin polymerization-IN-47
|
Microtubule Associated | Cytoskeletal Signaling |
Tubulin polymerization-IN-47 是一种 tubulin 聚合抑制剂和有丝分裂抑制剂,具有抗肿瘤活性,对神经母细胞瘤癌细胞增殖具有抑制作用,对 Chp-134 和 Kelly 细胞系的IC50 分别为 7 和 12 nM。Tubulin polymerization-IN-47 是治疗肝癌、结肠癌、肺癌和乳腺癌的候选化合物。 | |||
T4451 |
Estramustine phosphate sodium
Ro 21-8837/001,Estramustine phosphate disodium,雌莫司汀磷酸钠 |
Apoptosis; Microtubule Associated | Apoptosis; Cytoskeletal Signaling |
Estramustine phosphate sodium (Ro 21-8837/001) 是雌二醇类似物,是一种具有口服活性抗微管化疗剂,通过与微管相关蛋白和微管蛋白结合而使微管解聚。它可诱导前列腺癌细胞凋亡,可研究前列腺癌。 | |||
T62445 |
Tubulin inhibitor 22
|
Others | Others |
Tubulin inhibitor 22 (compound 4c) 是一种 tubulin 的有效抑制剂,表现出抗血管生成和抗癌活性。Tubulin inhibitor 22 能够将 MGC-803 细胞的细胞周期阻滞在 G2/M 期。Tubulin inhibitor 22 剂量依赖性地通过线粒体功能障碍引起 Caspase 诱导的 MGC-803 细胞凋亡 (apoptosis)。 | |||
T61472 |
Tubulin inhibitor 18
|
Others | Others |
Tubulin inhibitor 18 (compound 5j) is a highly potent chalcone compound that effectively inhibits tubulin. Its unique molecular structure renders Tubulin inhibitor 18 as a promising candidate for cancer research [1]. | |||
T72445 |
Tubulin inhibitor 30
|
Others | Others |
Tubulin inhibitor 30 是一种 tubulin 组合抑制剂,IC50为 0.52 μM。Tubulin inhibitor 30 可以诱导 ferroptosis。 | |||
T62058 |
αβ-Tubulin-IN-1
|
Others | Others |
αβ-Tubulin-IN-1 是有效且具有口服活性的αβ-Tubulin 抑制剂。αβ-Tubulin-IN-1 将细胞周期阻滞在 G2/M 期并诱导细胞凋亡 (apoptosis)。αβ-Tubulin-IN-1 抑制肿瘤细胞迁移和转移。αβ-Tubulin-IN-1 具有显著的抗肿瘤功效。 | |||
T62332 |
Tubulin inhibitor 13
|
Others | Others |
Tubulin inhibitor 13 (E27) 是一种有效的tubulin抑制剂,其对tubulin聚合的抑制IC50值为16.1 μM。该化合物不仅可以抑制癌细胞迁移和侵袭,还能诱导apoptosis,显示出抗癌活性。 | |||
T60459 |
Tubulin inhibitor 15
|
Others | Others |
Tubulin inhibitor 15 是有效的微管蛋白抑制剂,具有抗增殖活性。Tubulin inhibitor 15 在 HepG2 细胞中表现出细胞毒性。 | |||
T60460 |
Tubulin inhibitor 16
|
Others | Others |
Tubulin inhibitor 16 是有效的微管蛋白抑制剂,具有抗增殖活性。Tubulin inhibitor 16 在 HepG2 细胞中表现出细胞毒性。 | |||
T78761 |
Tubulin inhibitor 34
|
Others | Others |
Tubulin inhibitor 34 (compound b5) 为抗癌效果显著之化学药物,能够阻断微管蛋白(tubulin)聚合,促使G2/M期细胞周期停滞及细胞凋亡(apoptosis),并展现出明显的抗血管生成与抗肿瘤活性。 | |||
T72449 |
Tubulin inhibitor 31
|
Others | Others |
Tubulin inhibitor 31, 以IC50值4 µM的效力,是一种高效的微管蛋白(Tubulin)抑制剂,具有显著的抗增殖活性,并能抑制HUVEC的迁移。 | |||
T62922 |
Tubulin inhibitor 25
|
Others | Others |
Tubulin inhibitor 25 是一种微管蛋白 (tubulin) 的有效抑制剂 (IC50: 0.98 μM),能够显著抑制 HT29 细胞。Tubulin inhibitor 25 对细胞迁移和微管形成具有抑制作用,有助于抗血管生成。 | |||
T61524 |
Tubulin/HDAC-IN-1
|
Others | Others |
Tubulin/HDAC-IN-1 is a compound that functions as a dual inhibitor for tubulin and HDAC-IN-1. It achieves this by interacting with tubulin through CH/π interaction and with HDAC8 through hydrogen bond interaction. This compound effectively inhibits tubulin polymerization and selectively targets HDAC8 with an IC50 of 150 nM. Additionally, Tubulin/HDAC-IN-1 demonstrates cytotoxicity against various human cancer cells, induces cell cycle arrest in the G2/M phase, and triggers cell apoptosis. This c... | |||
T62498 |
Tubulin polymerization-IN-20
|
Others | Others |
Tubulin aggregation-IN-20 (compound 11) 是一种有效的 tubulin 聚合抑制剂。Tubulin aggregation-IN-20 具有潜力进行乳腺癌和耐药结肠癌的研究。 | |||
T62206 |
Tubulin polymerization-IN-19
|
Others | Others |
Tubulin aggregation-IN-19 (compound 4) 是一种有效 tubulin 聚合抑制剂,对乳腺癌和耐药结肠癌表现出研究潜力。 | |||
T62971 |
Tubulin polymerization-IN-16
|
Others | Others |
Tubulin aggregation-IN-16 (compound 5g) 是一种有效的 tubulin 聚合抑制剂。Tubulin aggregation-IN-16 对癌细胞有效 (IC50: 0.084-0.221 μM)。Tubulin aggregation-IN-16 能有效地破坏微管/管蛋白的动态,诱导 SGC-7901 细胞的细胞周期阻滞在 G2/M 期。 | |||
T61084 |
Tubulin polymerization-IN-37
|
Others | Others |
Tubulin polymerization-IN-37 is a potent inhibitor (IC50: 2.3 μΜ) of tubulin polymerization by binding specifically to the colchicine site of tubulin and preventing colchicine binding. It has potential applications in cancer research, notably for lymphomas [1]. | |||
T63836 |
Tubulin polymerization-IN-7
|
Others | Others |
Tubulin aggregation-IN-7 是有效的 tubulin 聚合抑制剂,对癌症疾病表现出研究潜力。 | |||
T62121 |
Tubulin polymerization-IN-3
|
Others | Others |
Tubulin polymerization-IN-3 是一种有效的微管蛋白聚合抑制剂 (IC50: 3.84 μM),能够诱导结肠癌细胞凋亡。 | |||
T79887 |
Tubulin polymerization-IN-49
|
Others | Others |
Tubulin polymerization-IN-49 (compound 12d) 是一种抑制微管蛋白聚合的有效化合物。它通过结合到微管蛋白的秋水仙碱位点来抑制其聚合。此外,Tubulin polymerization-IN-49 能够诱导细胞周期在 G2/M 期停滞并触发细胞凋亡,表现出对抗癌的活性,能够预防肿瘤的生成及抑制肿瘤增殖和血管生成。 | |||
T61242 |
Tubulin inhibitor 12
|
Others | Others |
Tubulin inhibitor 12 (Hit 9) is a recently developed compound with potent inhibitory effects on tubulin (IC50 = 25.3 μM). This compound exhibits noteworthy anti-tumor and anti-proliferative activities, making it a promising candidate for the treatment of cancer [1]. | |||
T73832 |
Tubulin inhibitor 21
|
Others | Others |
Tubulin inhibitor 21 (compound 6f) 为基于查尔酮与褪黑激素混合的有效tubulin抑制剂。该化合物对SW480细胞展现显著的细胞毒性活性(IC50=0.26 μM),对非恶性细胞的毒性较低。 | |||
T60793 |
Tubulin inhibitor 26
|
Others | Others |
Tubulin inhibitor 26 (compound 3c) 是一种吲唑衍生物,是微管蛋白抑制剂,对 HepG2、HCT116、SW620、HT29 和 A549 癌细胞系具有显著的低纳摩尔效力。Tubulin inhibitor 26 抑制G2/M 期肿瘤细胞,并且诱导细胞凋亡。Tubulin inhibitor 26 在体内抑制肿瘤生长,并且不影响小鼠体重。 | |||
T61545 |
Tubulin inhibitor 28
|
Others | Others |
Tubulin inhibitor 28 (compound 2g) 是一种有效的微管抑制剂,IC50值为 1.2 μM。Tubulin inhibitor 28 对 MCF-7 细胞具有抗增殖活性。 | |||
T78773 |
Tubulin inhibitor 38
|
Others | Others |
Tubulin inhibitor 38(化合物14)是一款强效的四唑基微管蛋白抑制剂,能够显著抑制细胞增殖。以100 nM浓度作用24小时后,该抑制剂能够引起有丝分裂停滞,特别是在G2/M期细胞周期阶段,进而诱导细胞凋亡。在HeLa、MCF7和U87 MG细胞系中,Tubulin inhibitor 38展现了较高的细胞毒性及选择性。 | |||
T78917 |
Tubulin inhibitor 33
|
Others | Others |
Tubulin inhibitor 33为一种抗微管蛋白聚合化合物,其抑制作用表现为剂量依赖性,具有9.05 μM的IC50。该化合物不仅具备抗肿瘤活性,还能诱导细胞凋亡(apoptosis),在抗肿瘤研究领域有应用潜力。 | |||
T78771 |
Tubulin inhibitor 36
|
Others | Others |
Tubulin inhibitor 36 (Compound 10) 是新型高效微管蛋白抑制剂,可阻止微管蛋白聚合并诱发细胞凋亡,IC50值为1.5±0.1 μM。该化合物在抗有丝分裂中表现出显著活性,并对胶质母细胞瘤(GBM)细胞线有效,适用于胶质母细胞瘤(GBM)的抗肿瘤研究。 | |||
T60402 |
Tubulin inhibitor 14
|
Others | Others |
Tubulin inhibitor 14 是一种有效的 NQO2(醌氧化还原酶 2)抑制剂,IC50 为 1.0 μM,也抑制微管蛋白聚合和内皮细胞毛细管样管的形成。Tubulin inhibitor 14 是一种微管去稳定剂,具有潜在的肿瘤选择性以及抗血管生成和血管破坏的功能[1]。 | |||
T78772 |
Tubulin inhibitor 37
|
Others | Others |
Tubulin inhibitor 37(化合物 12)作为Tubulin抑制剂,对Tubulin聚合表现出显著的抑制作用(IC50=1.3 µM)。此外,该化合物在人肿瘤细胞系上展现抗增殖潜力,因此对癌症研究颇具价值。 | |||
T60436 |
Tubulin inhibitor 17
|
Others | Others |
Tubulin inhibitor 17 (Compound 3b) 是微管蛋白聚合抑制剂(IC50 = 12.38 μM)。Tubulin inhibitor 17 显示出抗癌活性并且诱导细胞凋亡。 | |||
T60755 |
Tubulin inhibitor 20
|
Others | Others |
Tubulin inhibitor 20 (compound 1) 作为tubulin 的有效抑制剂,显示出癌症研究的潜力。 | |||
T63120 |
Tubulin inhibitor 23
|
Others | Others |
Tubulin inhibitor 23 是一种 Tubulin 的有效抑制剂 (IC50: 4.8 μM)。Tubulin inhibitor 23 以剂量依赖性方式表现出抗血管生成作用,并可诱导细胞凋亡。Tubulin inhibitor 23 具有潜力进行白血病的研究。 | |||
T61190 |
Tubulin inhibitor 27
|
Others | Others |
Tubulin inhibitor 27 (DYT-1) 是一种微管蛋白聚集 (tubulin polymerisation) 抑制剂,IC50为 25.6 μM。Tubulin inhibitor 27 具有抗血管生成活性和抗肿瘤活性。 | |||
T61459 |
Tubulin inhibitor 19
|
Others | Others |
Tubulin inhibitor 19 (compound 9b) is a potent indole chalcone compound that exhibits strong inhibitory activity against tubulin. Its potential in cancer research makes it valuable for studying cancer diseases [1]. | |||
T60568 |
Tubulin inhibitor 29
|
Others | Others |
Tubulin inhibitor 29 (compound 3c) 是一种有效的微管抑制剂,可抑制微管聚合并与秋水仙碱位点结合 (IC 50 = 1.2 μM)。Tubulin inhibitor 29 具有抗增殖作用,对人乳腺癌细胞 MCF-7 细胞的 IC50值为 7.5 μM。 | |||
T60735 |
Tubulin polymerization-IN-22
|
Others | Others |
Tubulin aggregation-IN-22 抑制细胞周期在 G2/M 期,并且诱导细胞凋亡。Tubulin aggregation-IN-22 是一种微管蛋白聚合抑制剂 (IC50 = 8.1 μM)。 | |||
T62369 |
Tubulin polymerization-IN-17
|
Others | Others |
Tubulin aggregation-IN-17 (compound 23g) 是一种 tubulin 聚合的有效抑制剂。Tubulin aggregation-IN-17 具有微管蛋白解聚作用,能够诱导细胞凋亡并抑制迁移。Tubulin aggregation-IN-17 具有潜力进行癌症疾病的研究。 | |||
T62040 |
Tubulin polymerization-IN-30
|
Others | Others |
Tubulin polymerization-IN-30 (compound 6e) 是有效的微管蛋白聚合 (Tubulin polymerization) 抑制剂,可破坏细胞内微管组织,将细胞周期阻滞在 G2/M 期。Tubulin polymerization-IN-30 对 HeLa、SGC-7901和A549 等肿瘤细胞系具有良好的抗肿瘤活性,其IC50分别为 0.403、 2.16和2.21 μM。 | |||
T63849 |
Tubulin polymerization-IN-34
|
Others | Others |
Tubulin polymerization-IN-34 是 [1,2] 恶唑异吲哚微管蛋白聚合的抑制剂,能够高度选择边缘区淋巴瘤 VL51 细胞系。 | |||
T72676 |
Tubulin/MMP-IN-1
|
Others | Others |
Tubulin/MMP-IN-1 是一种有效的tubulin 和MMP 抑制剂。Tubulin/MMP-IN-1具有研究癌症疾病的潜力。Tubulin/MMP-IN-1 抑制微管蛋白聚合,诱导细胞周期停滞在 G2/M 期,导致 HepG2 细胞产生反应性氧化应激 (ROS),并通过线粒体依赖性凋亡途径导致细胞凋亡[ 1]。 | |||
T79532 |
Tubulin polymerization-IN-44
|
Others | Others |
Tubulin polymerization-IN-44 (7w)为具高效性的微管蛋白聚合抑制剂,其IC50为0.21 μM。该化合物可诱发G2/M期阻塞并触发癌细胞凋亡(apoptosis),适用于肿瘤研究。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN2190 |
Scoulerine
|
Apoptosis; Beta-Secretase; BACE; Parasite | Apoptosis; Microbiology/Virology; Neuroscience |
Scoulerine 是抗有丝分裂化合物。它抑制细胞增殖,阻止细胞周期,并诱导癌细胞凋亡。它也是BACE1(淀粉样前体蛋白裂解酶 1) 的抑制剂。 | |||
T6212 |
Combretastatin A4
CA4,康普瑞汀,Z)-3,4,5,4',-四甲氧基-3'-羟基二苯乙烯,CRC 87-09 |
Microtubule Associated | Cytoskeletal Signaling |
Combretastatin A4 (CA4) 是一种微管靶向剂,可结合 β-tubulin,Kd 值为 0.4 μM。 | |||
T6272 |
Fosbretabulin Disodium
Combretastatin A4 Phosphate,CA 4DP,CA 4P,福他布林,Combretastatin A4 disodium phosphate,Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium |
Apoptosis; Microtubule Associated | Apoptosis; Cytoskeletal Signaling |
Fosbretabulin Disodium (CA 4P) 是一种微管蛋白去稳定剂,是 Combretastatin A4 前药,可选择性靶向内皮细胞,诱导新生肿瘤新血管消退,减少肿瘤血流量并引起中央肿瘤坏死。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00773 |
TUBB4A Protein, Human, Recombinant (His)
Tubulin β-4A Chain,Tubulin 5 ... |
Human | E. coli |
Tubulin Beta-4A Chain (TUBB4A) is a cytoplasmic peptide containing 444 amino acids. TUBB4A is a member of the Tubulin family. Tubulin is the major constituent of microtubules. Tubulin is a dimer composed of one alpha and one beta tubulin molecule; there are many forms of beta tubulins, Beta II and Beta IV Tubulin are ubiquitously expressed. Beta-III Tubulin, also known as Tubulin Beta-4, is regarded as a neuron-specific marker. It binds two moles of GTP, one at an exchangeable site on the beta c... | |||
TMPY-03059 |
Tubulin cofactor A Protein, Human, Recombinant
tubulin folding cofactor A |
Human | E. coli |
Tubulin folding cofactor A belongs to the TBCA family. It is one of four proteins (cofactors A, D, E, and C) involved in the early step of the tubulin folding pathway. These proteins can fold intermediates and finally lead to correctly folded beta-tubulin. It is believed that tubulin folding cofactors A and D play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Tubulin folding cofactor E binds to the cofactor D/beta-tubulin complex; interaction with... | |||
TMPH-00383 |
Tubulin beta-1 chain Protein, Chicken, Recombinant (His)
Tubulin beta-1 chain,Beta-tubulin class-I |
Chicken | E. coli |
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Tubulin beta-1 chain Protein, Chicken, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 53.3 kDa and the accession number is P09203. |