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ML67-33 rapidly and reversibly affects K2P2.1 (TREK-1) (EC50s: 36.3 μM and 9.7 μM in cell-free and HEK293 cells, respectively). ML67-33 is a selective activator of temperature- and mechano-sensitive K2P channels.
ML67-33 rapidly and reversibly affects K2P2.1 (TREK-1) (EC50s: 36.3 μM and 9.7 μM in cell-free and HEK293 cells, respectively). ML67-33 is a selective activator of temperature- and mechano-sensitive K2P channels.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
2 mg | ¥ 1,670 | 5日内发货 | |
25 mg | ¥ 7,690 | 6-8周 | |
50 mg | ¥ 9,990 | 6-8周 | |
100 mg | ¥ 15,600 | 6-8周 |
产品描述 | ML67-33 rapidly and reversibly affects K2P2.1 (TREK-1) (EC50s: 36.3 μM and 9.7 μM in cell-free and HEK293 cells, respectively). ML67-33 is a selective activator of temperature- and mechano-sensitive K2P channels. |
靶点活性 | K2P2.1 (TREK-1, HEK293 cells):9.7 μM(EC50), K2P2.1 (TREK-1):(EC50)36.3 μM |
体外活性 | ML67-33 activates K2P channels and mutants. It has an EC50s of 21.8±1.3 μM, 49.4±1.1 μM, 30.2±1.4 μM, and 27.3±1.2 μM for K2P2.1 (TREK-1) W275S, K2P2.1 (TREK-1)-3G, K2P10.1 (TREK-2), K2P4.1 (TRAAK), respectively. |
分子量 | 374.27 |
分子式 | C18H17Cl2N5 |
CAS No. | 1443290-89-8 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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