72
11
1
10
7
Cat. No. | Product Name | ||
---|---|---|---|
L6140 | 糖类及苷类化合物库 | 595 compounds | |
595 种糖类或苷类的化合物,可用于高通量筛选和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2712 |
Nifekalant hydrochloride
|
Potassium Channel | Membrane transporter/Ion channel |
Nifekalant hydrochloride 是一种 IKr 钾通道阻滞剂,IC50为10 µM,属于 III 类抗心律不齐化合物,可用于快速室上性心律失常的研究。 | |||
T15286 |
Flindokalner
BMS-204352 |
Potassium Channel | Membrane transporter/Ion channel |
Flindokalner (BMS-204352) 是一种钾离子通道调节剂。它是大电导钙激活 K 通道正向调节剂。它是在 HEK293 细胞中表达的所有神经元 Kv7通道亚型的正调节剂。它在 Kv7.1 通道 (Ki=3.7 μM) 处显示负调节活性,并充当 GABAA 受体的负调节剂。它在体内显示出抗焦虑功效。 | |||
T1496 |
Amiodarone hydrochloride
盐酸胺碘酮,Amiodar,Amiodarone HCl,Nexterone |
Potassium Channel; Adrenergic Receptor; Autophagy | Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience |
Amiodarone hydrochloride (Amiodarone HCl) 是一种抗心绞痛和 III 类抗心律失常药物,通过抑制钾通道和电压门控钠通道来增加心室和心房肌肉作用的持续时间,可导致心率和血管阻力降低。它通过成纤维细胞中的 ERK1/2和 p38 MAPK 信号传导诱导细胞增殖和肌成纤维细胞分化,可研究室上性和室性心律失常。 | |||
T20843 |
Aplodan
Nergize,Creatinolfosfate,磷酸肌肉醇,creatinol-O-phosphate,Creatinolfosfate, Creatinol Phosphate |
Others | Others |
Aplodan (creatinol-O-phosphate) 表现出抗缺血和抗心律失常的能力以及对细胞膜的保护作用。 Aplodan 可用于缺血性心脏病或伴有持续性室性早搏的缺血性心脏病的研究。 | |||
T1320 |
Disopyramide
Triombrin,Hypaque sodium,amidotrizoate sodium,达舒平 |
Potassium Channel; Sodium Channel; AChR | Membrane transporter/Ion channel; Neuroscience |
Disopyramide (Triombrin) 是用于研究房性和室性心律失常的 IA 类抗心律失常试剂。它阻断心肌快速内向钠电流,延长心肌动作电位持续时间。它抑制 HERG 编码的钾通道。它也表现出复杂的蛋白质结合,并具有强大的负性肌力作用。 | |||
T1101 |
Minocycline hydrochloride
Minocycline HCl,盐酸米诺环素,美满霉素 |
HIF/HIF Prolyl-Hydroxylase; Antibacterial; Antibiotic | Chromatin/Epigenetic; Metabolism; Microbiology/Virology |
Minocycline hydrochloride (Minocycline HCl) 属于四环素类抗生素,具有出色的吸收和组织渗透性。Minocycline hydrochloride 是一种广谱的抗菌剂,可用于多种细菌感染以及痤疮的治疗。 | |||
T7827 |
Glycyrrhizinic acid, potassium salt
|
Others | Others |
Glycyrrhizinic acid, potassium salt 可减轻藜芦醇引起的室性心律失常。 | |||
T6955 |
Propafenone hydrochloride
Propafenone HCl,Arythmol,SA-79 (hydrochloride),Rytmonorm,盐酸普罗帕酮,Rythmol |
Sodium Channel | Membrane transporter/Ion channel |
Propafenone hydrochloride (Arythmol8) 具有抗心律不齐的功效,可用于心房和心室性心律不齐。 | |||
T7386 |
Bretylium tosylate
溴苄乙胺,托西溴苄铵 |
Others | Others |
Bretylium tosylate 是交感神经和肾上腺素神经的阻断剂,是血管收缩的神经递质突触前释放的抑制剂。 | |||
T10634 |
Bunaftide
Bunaphtide,Meregon,Bunaftine |
Others | Others |
Bunaftide(Bunaphtid)具有抗心律失常作用,对乌头碱诱导的室性心动过速有抑制作用。 | |||
T28895 |
T-0509
T 0509,T0509 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
T-0509 是一种选择性 beta 1 受体激动剂,可增加犬心室肌的肌力,选择性下调大鼠心脏 β 1-肾上腺素受体。 | |||
T8581 |
Flecainide hydrochloride
|
Others | Others |
Flecainide hydrochloride 是一种用于预防和治疗异常快速心率的药物。这包括室性和室上性心动过速。 | |||
T32155 |
Indecainide
Ricainide,Ricainid,Decabid,Indecainidum,Indecainida |
Others | Others |
Indecainide (Ricainid) 是一种新型抗心律失常化合物,具有致癌性,可用于研究继发于冠状动脉疾病或心肌病的慢性稳定型室性心律失常。 | |||
T2189 |
Sodium orthovanadate
Sodium vanadate,钒酸钠,Trisodium vanadate,Sodium pervanadate |
ATPase; Phosphatase | Membrane transporter/Ion channel; Metabolism |
Sodium orthovanadate 是一种蛋白酪氨酸磷酸酶,碱性磷酸酶和一些ATP 酶的抑制剂,有可能充当磷酸盐类似物。它具有胰岛素样作用、对心室肌的正性肌力作用和其他代谢作用。 | |||
T68123 |
Oxodipine
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Oxodipine 是一种二氢吡啶型钙拮抗剂 ,抑制了KCl 诱导的兔主动脉收缩,降低了效力较低的大鼠心室试纸收缩的心脏力量。在大鼠培养的新生儿心室肌细胞中,Oxodipine 降低了L 型Ca 电流(I),IC 为0.24μM,对T 型Ca 电流(I)的IC 为0.41μM。Oxodipine 会使小鼠便秘和狗牙龈增生。 | |||
T83979 |
Sulcardine 2HCl
Sulcardine 2HCl(343935-60-4 Free base),HBI-3000 2HCl |
HER; Sodium Channel | Angiogenesis; JAK/STAT signaling; Membrane transporter/Ion channel; Tyrosine Kinase/Adaptors |
Sulcardine 2HCl 是一种多离子通道阻滞剂,具有抗心律失常作用,可阻断 hERG 和hNav1.5通道的特性,可用于研究心房颤动和室性心律失常。 | |||
T33589 |
Nanterinone
UK-61260,UK61260,UK 61260 |
PDE | Metabolism |
Nanterinone (UK 61260) 是一种口服的部分磷酸二酯酶抑制剂,是一种新型的正性肌力和平衡血管扩张化合物。Nanterinone 口服后,可使急性血流动力学得到明显改善,这可能取决于先前存在的左心室充盈压。 | |||
T30251 |
AZD-1305
UNII-CZO834LXQM,AZD 1305 |
Others | Others |
AZD-1305是一种新型抗心律失常化合物,主要阻断哺乳动物细胞和心室心肌细胞中 IKr 的快速组分、l 型钙电流和病房内钠电流,可用于研究逆转心律失常。 | |||
T24270 |
KS370G
KS-370-G,KS 370 G,Caffeic Acid Phenethyl Amide |
Others | Others |
KS370G (Caffeic Acid Phenethyl Amide) 抑制 UUO 诱导的肾纤维化标志物表达。KS370G 是一种具有口服活性的降糖和心血管保护剂,可减少梗阻肾脏中胶原蛋白的沉积,并显著降低肾脏炎症趋化因子/粘附分子和单核细胞标志物的表达,改善压力过载小鼠心脏左室肥厚和功能。KS370G 可用于研究肾阻塞性肾病。 | |||
T30249 |
AZD 7009
AZD-7009,AZD7009 |
Sodium Channel | Membrane transporter/Ion channel |
AZD 7009是一种新型抗心律失常化合物,对CHO K1细胞中 hNav1.5的钠电流具有抑制作用,IC50为11 uM。AZD 7009 对离体兔心房和心室肌细胞的晚期钠电流具有抑制作用,对e -4031诱导的动作电位持续时间延长具有抑制作用,促使浦肯野纤维的早期后去极化(EADs)。 | |||
T14077 |
A-935142
|
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
A-935142是一种人类醚-a-go-go 相关基因(hERG,Kv 11.1)通道激活剂。A-935142通过减慢失活、促进激活、减少失活、缩短心房和心室复极化,并通过一种复杂的方式增强 hERG 电流。 | |||
T6541 |
Ibutilide Fumarate
Corvert Fumarate,U70226E,富马酸伊布利特 |
Calcium Channel; Sodium Channel | Membrane transporter/Ion channel; Metabolism |
Ibutilide Fumarate (U70226E) 是一种 III 类抗心律失常药物,可作用于急性心梗阻塞。 | |||
T1012 |
Acebutolol hydrochloride
盐酸醋丁洛尔,Acebutolol HCl |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Acebutolol hydrochloride (Acebutolol HCl) 是一种 β-肾上腺素受体拮抗剂,用于研究高血压、心绞痛和心律失常。 | |||
T19722 |
Benazeprilat
CGS14831,CGS-14831,CGS 14831 |
RAAS; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Benazeprilat(CGS 14831) 是一种具有口服活性的贝那普利活性代谢物。Benazeprilat 具有高效的抗血压活性,可与其他其他类别的化合物(包括噻嗪类利尿剂和钙通道阻滞剂)联合使用来减少与心血管风险和继发性终末器官损伤相关的疾病的发生。Benazeprilat 可能用于研究急性左心室衰竭。 | |||
T68138 |
Saterinone
|
Adrenergic Receptor; PDE | GPCR/G Protein; Metabolism; Neuroscience |
Saterinone 是一种强效且具有选择性的磷酸二酯酶III 抑制剂,是血管α - 1-肾上腺素受体的有效拮抗剂。Saterinone 具有血管舒张作用,可用于慢性心力衰竭的急性治疗。Saterinone 对豚鼠右心室匀浆中粗cAMP 磷酸二酯酶(PDE)活性具有抑制作用,ic50值为2.3 × 10(-5) mol/l。 | |||
T0005 |
Aspirin
阿司匹林,Acetylsalicylate,Acetylsalicylic Acid,邻乙酰水杨酸,ASA |
Mitophagy; Virus Protease; COX; Autophagy | Autophagy; Immunology/Inflammation; Microbiology/Virology; Neuroscience |
Aspirin (Acetylsalicylic Acid) 是一种选择性 COX 抑制剂,具有多种药理活性。它是组蛋白去乙酰化酶抑制剂,可上调细胞周期阻滞蛋白 p21,抑制携带 COX-1 的卵巢 Y 细胞。 它还抑制 HUVEC 和新生大鼠心室心肌细胞中 COX-2 的表达,分别减少 PG 的产生和 ERK 和 NF-KB 的下调。 | |||
T0866 |
Propafenone
Rythmol,普罗帕酮,Propafenonum |
Potassium Channel; MRP; Sodium Channel | Immunology/Inflammation; Membrane transporter/Ion channel |
Propafenone (Propafenonum) 是钠通道阻滞剂,它对 β 受体具有高亲和力 (IC50=32 nM)。它能够阻断瞬时外向钾电流 (Ito) (IC50: 4.9 nM) 和持续延迟整流器K+电流 (Isus) (IC50: 8.6 nM) ,具有抗心律失常的作用。它能够诱导线粒体功能障碍及诱导细胞凋亡,从而抑制食管癌增殖。 | |||
T15487 |
HMR 1556
|
Others | Others |
HMR 1556 is a chromanol derivative and is an IKs blocker (IC50s of 10.5 nM and 34 nM in canine and guinea pig left ventricular myocytes, respectively). | |||
T16127 |
Moricizine
Moracizine,莫雷西嗪 |
Others | Others |
Moricizine is an antiarrhythmia agent which is used primarily for ventricular rhythm disturbances. | |||
T21424 |
Disopyramide phosphate
SC13957,SC 13957,SC-13957 |
Others | Others |
Disopyramide, a sodium channel blocker in the Class of 1a anti-arrhythmic agent, is used in the treatment of Ventricular Tachycardia. Disopyramide has a negative inotropic effect on the ventricular myocardium, resulting in a significant decrease in contra | |||
T26136 |
RS 2135
RS2135,RS-2135 |
Others | Others |
RS 2135 is a novel class I antiarrhythmic agent to inhibit ischemia-induced ventricular arrhythmias. | |||
T68252 |
Mesotrin
|
Others | Others |
Mesotrin is a calcium antagonist that influences atrial and ventricular conduction, but has been linked with side effects of euphoria, ventigo and heavyheadedness. | |||
T32426 |
KT 1
KT-1,KT1 |
Others | Others |
KT 1 decreased aortic pressure, renal blood flow, left ventricular enddiastolic pressure and resistances of total peripheral, vertebral, coronary and renal vasculatures and increased aortic blood flow, vertebral blood flow, coronary blood flow, peak posit | |||
T15755 |
Lidoflazine
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Lidoflazine is a high-affinity blocker of the HERG K+ channel and is an antianginal calcium channel blocker. It carries an obvious risk of QT interval prolongation and ventricular arrhythmia. | |||
T40777 |
Encainide
Encainide,MJ9067 |
Others | Others |
Encainide (MJ9067), a class IC antiarrhythmic drug, holds potential for research into life-threatening and symptomatic ventricular arrhythmias as well as supraventricular arrhythmias. | |||
T5336L |
Zacopride
Racemic zacopride |
Others | Others |
Zacopride is a selective agonist of inward rectifier potassium current (I K1) channel, inhibiting ventricular arrhythmias without affecting atrial arrhythmias. | |||
T32030 |
GYKI-16638 HCl
GYKI 16,638,GYKI16,638,GYKI-16638,GYKI-16,638,GYKI16638,GYKI 16638 |
Others | Others |
GYKI-16638 is a novel antiarrhythmic agent that demonstrates combined class IB and class III antiarrhythmic properties in human ventricular muscles, similar to the electrophysiological findings after chronic amiodarone treatment. In addition, GYKI 16638 h | |||
T69119 |
Disopyramide HCl
|
Others | Others |
Disopyramide HCl is the salt form of Disopyramide, an antiarrhythmic medication used in the treatment of ventricular tachycardia. It is a sodium channel blocker and therefore classified as a Class 1a anti-arrhythmic agent. Disopyramide has a negative inotropic effect on the ventricular myocardium, significantly decreasing the contractility. Disopyramide also has an anticholinergic effect on the heart which accounts for many adverse side effects. Disopyramide is available in both oral and intrave... | |||
T28321 |
PD 122860
PD-122860,PD122860 |
Others | Others |
PD 122860 is a dihydropyridine with calcium channel blocking and sodium channel stimulating properties. In the rat heart, PD 122860 increased left ventricular contractility, decreased coronary resistance and altered the shape of the electrocardiogram T-wa | |||
T22685 |
CP-471474
CP 471474 |
Others | Others |
Broad spectrum MMP inhibitor (IC<sub>50</sub> values are 0.7, 0.9, 13, 16 and 1170 nM for MMP-2, MMP-13, MMP-9, MMP-3 and MMP-1 respectively). Attenuates early left ventricular dilation after experimental myocardial infarction in mice. | |||
T14153 |
Aladorian
ARM036 |
Others | Others |
Aladorian (ARM036) is a benzothiazepine derivative and it has anti-arrhythmia effect. Aladorian is used for the research of heart failure and catecholaminergic polymorphic ventricular tachycardia[1][2]. | |||
T26875 |
BN 50739
BN50739,BN-50739 |
Others | Others |
BN 50739 is an antagonist of platelet-activating factor (PAF). BN 50739 suppresses certain cardiac arrhythmias. PAF is released from ischaemic myocardium and may contribute to initiation of ischaemia-induced ventricular fibrillation (VF) | |||
T35832 |
Brain Natriuretic Peptide (1-32), rat acetate
|
||
Brain Natriuretic Peptide (1-32), rat acetate (BNP (1-32), rat acetate) is a 32 amino acid polypeptide hormone synthesized by ventricular cardiomyocytes as a result of myocardial cell stretching (cardiomyocyte distension)[1]. | |||
T21373 |
Aprindine hydrochloride
Fiboran,Amidonal,Aprinidine,Aprindin,Aprindine HCl,Aprindina,Fibocil |
Others | Others |
Aprindine HCl is a Class 1b antiarrhythmic agent used to manage ventricular and supraventricular arrhythmias. In one study, it delayed atrial fibrillation more than digoxin did. It has shown effectiveness when given orally. | |||
T31119 |
CVT-2759
UNII-42E8N8RC9Z,CVT2759 |
Others | Others |
CVT-2759 is A potential partial agonist for A(1)-ADORs, and it may be useful to slow atrioventricular node conduction to reduce ventricular rate without causing the atrioventricular block, bradycardia, atrial arrhythmias, or vasodilation. | |||
T36561 |
(3S)-hydroxy Quinidine
|
Others | Others |
(3S)-hydroxy Quinidine is an active quinidine metabolite. Quinidine, an antiarrhythmic agent, undergoes rapid first-pass metabolism by the cytochrome P450 (CYP) isoforms CYP3A4, CYP2C9, CYP2E1, and CYP3A5, with CYP3A4 being the most active enzyme in the (3S)-hydroxy quinidine formation. (3S)-hydroxy Quinidine prolongs repolarization of canine Purkinje fibers in vitro and prevents ventricular fibrillation and ventricular tachycardia after coronary reperfusion in isolated rat hearts in a dose-depe... | |||
T28567 |
Ro 22-9194
Ro-22-9194 |
Others | Others |
Ro 22-9194 is a class I antiarrhythmic agent. Ro 22-9194 (>=10 μM) caused a concentration-dependent decrease in the maximum upstroke velocity and shortening of action potential duration in guinea-pig ventricular cells. | |||
T21391 |
Flecainide
Tambocor,Apocard,Flecainida,Flecainidum |
Others | Others |
Flecainide acetate is a class Ic antiarrhythmic agent, it is used to treat a variety of cardiac arrhythmias including paroxysmal atrial fibrillation, paroxysmal supraventricular tachycardia, and ventricular tachycardia. It works by regulating the flow of | |||
TP1208 |
Nesiritide
BNP-32,Brain Natriuretic Peptide-32 human,奈西立肽 |
||
Nesiritide is the recombinant form of the 32 amino acid human B-type natriuretic peptide, which is normally produced by the ventricular myocardium. It is an agonist of natriuretic peptide receptors (NPRs), with Kd values of 7.3 and 13 pM for NPR-A and NPR | |||
T3689L |
Ruboxistaurin mesylate
LY-333531,LY333531,LY 333531,LY-333531 Mesylate |
Others | Others |
Ruboxistaurin is a PKC beta inhibitor. Ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/ |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4550 |
Ajmaline
Cardiorythmine,Raugalline,阿义吗啉,阿义马林,Tachmalin,(+)-Ajmaline |
Sodium Channel | Membrane transporter/Ion channel |
Ajmaline (Cardiorythmine) 是一种钠通道阻断剂,属于1A 类抗心律失常剂。Ajmaline 阻断 HERG 电流,在 HEK 细胞的 IC50为 1 μM,爪蟾卵母细胞的IC50为 42.3 μM。Ajmaline 在室性心动过速方面具有研究价值。 | |||
T5573 |
Coenzyme Q9
辅酶Q9,Ubiquinone Q9,Ubiquinone 9,CoQ9 |
Apoptosis; Endogenous Metabolite | Apoptosis; Metabolism |
Coenzyme Q9 (Ubiquinone 9) 是啮齿类动物泛醌的主要形式,是电子传递链中的一种双亲分子组分,具有内源性抗氧化剂的作用。它可减轻糖尿病引起的抗氧化防御机制的下降,改善左心室功能,减少心肌梗死面积和心肌细胞凋亡。 | |||
T3S0629 |
Delsoline
Belsoline,硬飞燕草碱 |
Others | Others |
Delsoline (Belsoline) 是一种还亮草的主要生物碱,具有类似箭毒的效果和神经节阻滞作用,可用于肌肉紧张或运动过度的缓解。其中还亮草具有祛风除湿,止痛,活络的功效,可用于风湿,偏瘫,消化不良和咳嗽的研究。 | |||
T5S1099 |
Liensinine
|
Apoptosis; Mitophagy; Others; Autophagy | Apoptosis; Autophagy; Others |
Liensinine 是一种自噬/线粒体自噬抑制剂。Liensinine 是从芙蕖种子胚中提取的,一种主要的异喹啉生物碱,具抗心律不齐、抗高血压、抗肺纤维化、血管平滑肌松弛等广泛的生物活性。 | |||
T5968 |
DL-Homocysteine thiolactone hydrochloride
DL-Homocysteinethiolactone hydrochloride,DL-高半胱氨酸硫内酯盐酸盐 |
Endogenous Metabolite | Metabolism |
DL-Homocysteine thiolactone hydrochloride (DL-Homocysteinethiolactone hydrochloride) 是具有根生长抑制特性的环状氨基酸衍生物。 | |||
T2803 |
Monocrotaline
野百合碱,Crotaline |
TGF-beta/Smad | Stem Cells |
Monocrotaline (Crotaline) 是一种吡咯里西啶生物碱,从猪屎豆植物的种子中提取得到,可诱导啮齿动物产生肺动脉高血压。 | |||
T7044 |
Norepinephrine
去甲肾上腺素,Levophed,Levonoradrenaline,Aktamin,Nor-Epirenan,Levonor,Arterenol |
MMP; Endogenous Metabolite; Adrenergic Receptor; Autophagy | Autophagy; GPCR/G Protein; Metabolism; Neuroscience; Proteases/Proteasome |
Norepinephrine (Levophed) 属于生物碱类天然产物,是一种神经递质,一种肾上腺素能受体 (AR) 的激动剂,对 α1、α2 和 β1 AR 具有激活活性。Norepinephrine 被用作抗休克的血管活性剂。 | |||
T3S0626 |
Denudatine
光翠雀碱;裸翠雀亭,光翠雀碱 |
Others | Others |
Denudatine 是分离自乌头属和翠雀属植物中,能够影响心室纤维的动作电位,并抑制乌头碱的致心律失常作用。 | |||
TN1367 |
Alismol
泽泻醇 |
Potassium Channel; Calcium Channel; PI3K | Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling |
Alismol has antihypertensive action, it decreases cardiac output, heart rate and left ventricular pressure, but it increases coronary flow, it has been used for the prevention of anginal attacks. | |||
TN1875 |
Liriodenine
鹅掌揪碱 |
BCL; Caspase; p53 | Apoptosis; Proteases/Proteasome |
Liriodenine is a potent inhibitor of topoisomerase II (EC 5.99.1.3) both in vivo and in vitro, it has antitumor, antibacterial and antifungal activities, it can suppress ventricular arrhythmias induced by myocardial ischaemia reperfusion, through inhibiti | |||
TN4616 |
N-Methyltaxol C
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Others | Others |
N-methyltaxol C and paclitaxel can produce a positive inotropic effect in papillary muscle, without alterations in the action potential. They can induced conduction arrhythmias and reduce coronary flow and left ventricular systolic pressure in the isolate |
Cat. No. | Product Name | Species | Expression System |
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TMPH-01725 |
MYL3 Protein, Human, Recombinant (GST)
Ventricular myosin alkali light chain,Ventricul... |
Human | E. coli |
Regulatory light chain of myosin. Does not bind calcium. MYL3 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 48.8 kDa and the accession number is P08590. | |||
TMPH-02968 |
VEPH1 Protein, Mouse, Recombinant (His & Myc)
Veph1,Protein melted homolog,Ventricular zone-expre... |
Mouse | E. coli |
Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling. VEPH1 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 27.7 kDa and the accession number is A1A535. | |||
TMPH-01343 |
FILIP1 Protein, Human, Recombinant (His & Myc)
FILIP1,Filamin-A-interacting protein 1 |
Human | E. coli |
By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A. FILIP1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 30.2 kDa and the accession number is Q7Z7B0. | |||
TMPH-03375 |
Stathmin-2 Protein, Rat, Recombinant (His)
Superior cervical ganglion-10 protein,Stmn2,Stathmin-2 |
Rat | E. coli |
Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone. Stathmin-2 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 26.7 kDa and the accession number is P21818. | |||
TMPJ-01277 |
CRT2 Protein, Human, Recombinant
CALR3,Calreticulin-3,calreticulin-2,calsperin,CRT2 |
Human | E. coli |
Calreticulin-3 belongs to the calreticulin family, members of which are calcium binding chaperones localized mainly in the endoplasmic reticulum. It can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. During spermatogenesis process, Calreticulin-3 may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Defects in CALR3 are the cause of familial hypertrophic cardiomyopathy t... | |||
TMPJ-01129 |
SMAD1 Protein, Human, Recombinant (GST)
hSMAD1,Transforming Growth Factor-Beta-Signaling Protein 1,T... |
Human | E. coli |
SMAD Family Member 1 (SMAD1) is a member of the dwarfin/SMAD family. SMAD1 has the highest expression in the heart and skeletal muscle, containing one MAD homology 1 domain and one MAD homology 2 domain, As a transcriptional modulator SMAD 1 is activated by bone morphogenetic proteins type 1 receptor kinase. Defects in SMAD1 may cause primary pulmonary hypertension (PPH1), characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated ... | |||
TMPJ-00874 |
NT-proBNP Protein, Human, Recombinant (His & Flag)
γ-brain natriuretic peptide,Gamma-brain natriuretic peptide,... |
Human | E. coli |
Brain-type Natriuretic Peptide (BNP) is a nonglycosylated peptide that is produced predominantly by ventricular myocytes and belongs to the natriuretic peptide family. Proteolytic cleavage of the 12 kDa BNP precursor gives rise to N-terminal Pro BNP (NT-proBNP) and mature BNP. N-terminal proB-type natriuretic peptide (NT-proBNP), a useful marker of heart failure (HF), is considered to be secreted mainly from the ventricle, increased serum NT-proBNP levels are also encountered in conditions such ... | |||
TMPY-03811 |
KCT2 Protein, Human, Recombinant (His)
chromosome 5 open reading frame 15,KCT2,HTGN29 |
Human | HEK293 Cells |
C5orf15 (Chromosome 5 Open Reading Frame 15, also known as KCT2) is a Protein Coding gene. KCT2 gene maps to human chromosome 5q31.1 and is conserved in human, chimpanzee, cow, rat, and chicken. KCT2 is a 265 amino acid single-pass type I membrane protein that is widely expressed in the thyroid, kidney, and other tissues. Chromosome 5 is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. ... | |||
TMPY-02300 |
BIN1 Protein, Human, Recombinant (His)
AMPHL,bridging integrator 1,AMPH2,SH3P9 |
Human | E. coli |
Amphiphysin 2, also named bridging integrator-1 (BIN1) or SH3P9, Amphiphysin2/BIN1 is a crescent-shaped N-BAR protein playing a key role in forming deeply invaginated tubes in muscle T-tubules, has been recently implicated in rare and common diseases affecting different tissues and physiological functions. BIN1 downregulation is linked to cancer progression and also correlates with ventricular cardiomyopathy and arrhythmia preceding heart failure. Increased BIN1 expression is linked to increased... | |||
TMPJ-00952 |
SDF-1/CXCL12 Protein, Mouse, Recombinant
Sdf1,C-X-C motif chemokine 12,Thymic lymphoma cell-stimulati... |
Mouse | E. coli |
Mouse Cxcl12 is a secreted and highly conserved protein which belongs to the intercrine alpha (chemokine CxC) family.CXCL12 is widely expressed in various organs including brain, kidney, skeletal muscle, heart, liver, and lymphoid organs. Cxcl12 activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. It also binds to atypical chemokine receptor ACKR3 which activates the beta-arrestin pathway and acts as a scaven... |
Cat. No. | Product Name | Target | Signaling Pathways |
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TMIJ-0501 |
Propafenone-d5 HCl
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Propafenone-d5 HCl 是 Propafenone HCl 的氘代化合物。Propafenone HCl 的 CAS 号为 34183-22-7。Propafenone HCl 具有抗心律不齐的功效,可用于心房和心室性心律不齐。 | |||
T71065 |
Quinapril-d5
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Quinapril-d5 is intended for use as an internal standard for the quantification of quinapril by GC- or LC-MS. Quinapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor quinaprilat. In vivo, quinapril reduces mean arterial pressure in renal hypertensive and spontaneously hypertensive rats. It inhibits angiotensin I-induced pressor responses in normotensive rats and dogs. Quinapril prevents left ventricular heart failure in CHF 14.6 cardiomyopathic hamsters. Formulations con... | |||
T71205 |
Fosinopril-d7 sodium salt
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Fosinopril-d7 is intended for use as an internal standard for the quantification of fosinopril by GC- or LC-MS. Fosinopril is a prodrug form of the angiotensin-converting enzyme inhibitor fosinoprilat. Oral administration of fosinopril inhibits angiotensin I-induced pressor responses in normotensive rats, dogs, and monkeys when administered at doses of 15, 15, and 10 µmol/kg, respectively. Fosinopril reduces fractional shortening and decreases left ventricular size in a porcine model of congesti... | |||
T69600 |
Spermidine-d6
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Spermidine-d6 is intended for use as an internal standard for the quantification of spermidine by GC- or LC-MS. Spermidine is an endogenous polyamine. It is formed from putrescine by spermidine synthase. Spermidine (25 µM) inhibits the activity of the human inward-rectifying potassium channel Kir2.3 in a patch-clamp assay. It induces autophagy in HeLa cells when used at a concentration of 100 µM and increases the lifespan of D. melanogaster, yeast, and C. elegans. Spermidine (30 mM in the drinki... | |||
TMIJ-0252 |
Benazeprilat-d5
Benazepril EP Impurity C-d5 |
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Benazeprilat-d5 是 Benazeprilat 的氘代化合物。Benazeprilat 的 CAS 号为 86541-78-8。Benazeprilat(CGS 14831) 是一种具有口服活性的贝那普利活性代谢物。Benazeprilat 具有高效的抗血压活性,可与其他其他类别的化合物(包括噻嗪类利尿剂和钙通道阻滞剂)联合使用来减少与心血管风险和继发性终末器官损伤相关的疾病的发生。Benazeprilat 可能用于研究急性左心室衰竭。 | |||
TMID-0070 |
Amiodarone-d10 Hydrochloride
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Amiodarone-d10 Hydrochloride 是 Amiodarone Hydrochloride 的氘代化合物。Amiodarone Hydrochloride 的 CAS 号为 19774-82-4。Amiodarone hydrochloride是一种抗心绞痛和 III 类抗心律失常药物,通过抑制钾通道和电压门控钠通道来增加心室和心房肌肉作用的持续时间,可导致心率和血管阻力降低。它通过成纤维细胞中的ERK1/2和p38 MAPK信号传导诱导细胞增殖和肌成纤维细胞分化,可研究室上性和室性心律失常。 | |||
TMID-0069 |
Amiodarone-d4 HCl
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Amiodarone-d4 HCl 是 Amiodarone HCl 的氘代化合物。Amiodarone HCl 的 CAS 号为 19774-82-4。Amiodarone hydrochloride是一种抗心绞痛和 III 类抗心律失常药物,通过抑制钾通道和电压门控钠通道来增加心室和心房肌肉作用的持续时间,可导致心率和血管阻力降低。它通过成纤维细胞中的ERK1/2和p38 MAPK信号传导诱导细胞增殖和肌成纤维细胞分化,可研究室上性和室性心律失常。 |