toxic

Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78)为T细胞增殖激活剂，以剂量依赖性方式增强人外周血单核细胞(PBMC)的体外增殖，适用于癌症与炎症免疫研究。

Elamipretide (MTP-131) 是一种线粒体靶向抗氧化四肽 (D-Arg-dimethylTyr-Lys-Phe-NH2)，可以减少有毒活性氧的产生并稳定心磷脂，具有血脑屏障渗透性。Elamipretide 是罕见病巴氏综合征的潜在治疗剂。

Melittin TFA(20449-79-0(free base)) 是一种含有 26 个氨基酸残基的小蛋白质，是蜂毒的主要毒性成分。它是一种 PLA2 活化剂，可刺激低分子量 PLA2 的活性，而不会增加高分子量 PLA2 的活性。

Argireline (Acetyl hexapeptide-3) 是可渗透皮肤的、无毒的抗皱肽。它对神经肌肉接头处依赖 Ca2+的神经递质释放具有显著的抑制作用。它具有抗皱和抗衰老的活性。

[Asn23] β-Amyloid (1-40), Iowa mutation 是一种与重度大脑淀粉样蛋白血管病 (CAA) 相关的生物活性肽。该突变涉及 APP 694 位点的错义突变，Asp 23 位置的天冬酰胺被天冬酰氨酸取代。这种变异的 β-Amyloid 肽倾向于更快聚集，并形成有害的原纤维。

μ-Conotoxin SIIIA为TTX抗性sodium channel拮抗剂，属于毒性肽类，源自Conus snails毒液。该化合物主要应用于神经系统疾病，尤指神经性疼痛的研究。

Amyloid (1-42), rat is a polypeptide composed of 42 amino acids. It is toxic to hippocampal slices and can be used in the study of alzheimer's disease.

H-Leu-Leu-OMe HBr (L-Leucyl-L-Leucine methyl ester HBr) 是 L-亮氨酸甲酯的二肽缩合产物，是对自然杀伤 T 细胞有毒性的肽，具有免疫抑制活性，可消除混合淋巴细胞群中的所有自然杀伤细胞 （NK） 功能。

Elamipretide acetate (MTP 131 acetate) 是Elamipretide 衍生物。Elamipretide 是一种小的线粒体靶向四肽(D-Arg-dimethylTyr-Lys-Phe-NH2)，可用于研究减少有毒活性氧的产生和稳定心磷脂。

β Amyloid(17-28) human 为β-淀粉样肽(Abeta)的一段核心片段，其结构受脂质诱导。本化合物能够促进β Amyloid40全长肽段的聚集，导致阿尔茨海默病(AD)中具毒性的聚集体形成。

Phytochelatin 5 TFA为植物合成的金属结合化合物，有潜在降低食物中有毒金属（例如镉）生物可利用性的作用。

Melittin 是 PLA2激活剂，能够刺激低分子量 PLA2的活性，而不刺激高分子量 PLA2的活性。

Melittin (C-term cysteine labeled)是一种衍生自具有细胞毒性的蜂毒肽melittin的衍生物，其在C-末端具有一个半胱氨酸残基。它能够在内体和细胞外pH条件下引发人类红细胞的溶血作用（分别在pH 5.5和7.4时的EC50s为5和6 µM）。Melittin (C-term cysteine labeled)已被用于合成膜溶解性聚合物，这些聚合物已用于体外和体内质粒递送的polyplexes的生成。

β-Amyloid (1-14),mouse,rat is a 1 to 14 fragment of Amyloid-β peptide. β-Amyloid (1-14),mouse,rat is produced through the proteolytic processing of a transmembrane protein, amyloid precursor protein (APP), by β- and γ-secretases. β-Amyloid (1-14),mouse,rat accumulation in the brain is proposed to be an early toxic event in the pathogenesis of Alzheimer’s disease, which is the most common form of dementia associated with plaques and tangles in the brain[1]. [1]. Chen GF, et al. Amyloid beta: structure, biology and structure-based therapeutic development. Acta Pharmacol Sin. 2017 Sep;38(9):1205-1235.

Conotoxin GII is a highly toxic peptide.

Aam-KTX，一种从蝎子Mesobuthus eupeus毒液中提取的毒性肽类Kv通道抑制剂，对Kv1.3和Kv1.1的IC50值分别为1.1 nM和＞750 nM。Aam-KTX在研究自身免疫性疾病方面显示出潜在应用价值。

Amp1EP9为一抗菌肽，作为开发有效无毒抗菌活性分子的强大工具，具备针对多重耐药细菌感染进行研究的潜力。

Phytochelatin 6是一种植物所产生的金属结合化合物，其可能降低（如镉）等膳食有毒金属的生物利用度。

μ-Conotoxin BuIIIA是从Cone snails毒液中提取的一种毒性肽类VGSC阻滞剂，常用于神经系统疾病的研究。

The leguminous shrub,Leucaena leucocephala(Leucaena) is wide‐spread in tropical and subtropical agricultural systems and provides a ready source of protein for livestock. However, the presence of mimosine, a non‐protein, amino acid comprising about 12% of the dry matter in growing tips ofLeucaena, is toxic to animals. Mimosine is degraded rapidly in the rumen to produce 3,4‐dihydroxypyridine (3,4‐DHP) and 2,3‐dihydroxypyridine (2,3‐DHP), both of which remain toxic to animals[1]. 3,4-DHP, as a derivative of the plant amino acid mimosine, is goitrogenic in cattle, sheep, and mice. In contrast to established antithyroid compounds, such as methimazole (MMI) and propylthiouracil (PTU), 3,4-DHP has no SH-group. 3,4-DHP with various concentrations inhibited incorporation of125I into protein in human thyroid slices. It also suppressed the activation of lymphocytes by PHA (phytohaemagglutinin) and PWM (pokeweed mitogen). Suppression with 3,4-DHP was seen at 100 and 1000 μmol/L (P< 0.001 vs both PHA and PWM). Those, together with a very low murine bone marrow toxicity, probably related to the absence of an SH-group, make 3,4-DHP a potential antithyroid drug[2].

Temporin A, a short alpha-helical antimicrobial peptide derived from the skin of Rana temporaria, exhibits a wide-ranging efficacy against Gram-positive bacteria. It directly interacts with the cell membrane of microorganisms and remains non-toxic to erythrocytes at antimicrobial concentrations. Additionally, Temporin A demonstrates antifungal properties against yeast-like Candida albicans.

Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone 是一种细胞渗透性且无毒的抑制剂，它能与活化的caspase-3在凋亡细胞内不可逆结合。该抑制剂的荧光强度可通过流式细胞仪、微孔板读数器或荧光显微镜检测。

Oxytocin parallel dimer TFA为具有催产素和加压素样活性的二硫键桥连同肽二聚体，其毒性低于催产素。

Phytochelatin 6 TFA为植物合成的金属结合化合物，具有降低如镉等膳食有毒金属的生物可利用性的潜能。

Phytochelatin 5为植物合成的金属结合化合物，具有可能降低如镉等膳食有毒金属的生物利用度。