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Targets Recommended: HSP

140

抑制剂 & 化合物

32

天然产物

66

重组蛋白

1

同位素标记化合物

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Cat. No. Product Name Target Signaling Pathways
T2444 KNK437

Heat Shock Protein Inhibitor I

HSP Cytoskeletal Signaling; Metabolism
KNK437 (Heat Shock Protein Inhibitor I) 是一种 HSP 抑制剂,抑制 HSP40,HSP70 和 HSP105 的活化。
T36865 Heat Shock Protein Inhibitor II

Others Others
Heat shock protein (Hsp) inhibitor II is the active form of Hsp inhibitor I and a benzylidene lactam compound that prevents the synthesis of inducible Hsps, such as Hsp105, Hsp72, and Hsp40. Hsp inhibitor II decreases Hsp72 synthesis in vivo and reduces thermotolerance of tumors in SCC VII tumor-containing mice. At 100 μM, it inhibits the development of thermotolerance in COLO 320 DM cells. Inhibition of Hsp70 with Hsp inhibitor II in combination with amphotericin B increases susceptibility of A...
T3594 ML346

HSP Cytoskeletal Signaling; Metabolism
ML346是 Hsp70和 HSF-1活性的激活剂,针对 Hsp70 的 EC50为 4.6 μM。它诱导热休克反应 (HSR) 的基因和蛋白质效应子的特异性增加,如 Hsp70、Hsp40 和 Hsp27。
T8668 HM03

HSP Cytoskeletal Signaling; Metabolism
HM03 是一种有效的选择性 HSPA5 抑制剂,具有抗癌活性。
T4125 HSF1A

HSP Cytoskeletal Signaling; Metabolism
HSF1A 是一种可渗透细胞的 HSF1 激活剂,可保护哺乳动物细胞免受应激诱导的细胞凋亡。它还是 TRiC/CCT 的特异性抑制剂。
T80964 Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78)

Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78)为T细胞增殖激活剂,以剂量依赖性方式增强人外周血单核细胞(PBMC)的体外增殖,适用于癌症与炎症免疫研究。
T6248 XL888

HSP Cytoskeletal Signaling; Metabolism
XL888 是一种 ATP 竞争性的 Hsp90 抑制剂,IC50值为 24 nM。
T3487 HSP70-IN-1

Others; HSP Cytoskeletal Signaling; Metabolism; Others
HSP70-IN-1是一种热休克蛋白 (HSP) 抑制剂,可抑制 Kasumi-1 细胞的生长,IC50值为2.3 μM。
T8858 DTHIB

HSP Cytoskeletal Signaling; Metabolism
DTHIB 是一种选择性热休克蛋白 1 的直接抑制剂,与 HSF1 DNA 结合域结合的Kd 为 160 nM。它选择性刺激核HSF1的降解,强烈抑制 HSF1 癌症基因特征和前列腺癌细胞增殖。
T6558 KW-2478

KW2478

HSP Cytoskeletal Signaling; Metabolism
KW-2478 是一种非安沙霉素Hsp90α抑制剂,IC50值为 3.8 nM。它对多种人类血液肿瘤细胞具有抗肿瘤活性。
T5008 Teprenone

Tetraprenylacetone,Geranylgeranylacetone,替普瑞酮

HSP Cytoskeletal Signaling; Metabolism
Teprenone (Geranylgeranylacetone) 是一种热休克蛋白诱导剂,有抗溃疡作用。
T3652 KRIBB11

Apoptosis; HSP Apoptosis; Cytoskeletal Signaling; Metabolism
KRIBB11 是一种热休克因抑制剂。
T6855 HA15

Apoptosis; GPR; Others; HSP; Autophagy Apoptosis; Autophagy; Cytoskeletal Signaling; Endocrinology/Hormones; GPCR/G Protein; Metabolism; Others
HA15 是一种高效特异性内质网伴侣蛋白BiP/GRP78/HSPA5抑制剂,抑制 BiP 的 ATP 酶活性,具有抗肿瘤活性。
T2309 Ganetespib

STA-9090

Apoptosis; HSP; HIF Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism
Ganetespib (STA-9090) 是一种热休克蛋白 90 抑制剂,通过抑制 HIF-1α 和 STAT3 对大肠癌具有抗血管生成作用。它还具有细胞毒性。
T3527 TRC051384

TRC 051384

HSP Cytoskeletal Signaling; Metabolism
TRC051384 是一种热休克蛋白70 (HSP70) 诱导剂,可减少中风相关的神经元损伤并增加短暂性缺血性中风大鼠模型的存活率,激活热休克因子-1 并导致分子伴侣和抗炎活性升高,增强神经元和神经胶质细胞中 Hsp72 的表达。
T7010 VER-155008

VER155008

GPR; HSP; Autophagy Autophagy; Cytoskeletal Signaling; Endocrinology/Hormones; GPCR/G Protein; Metabolism
VER-155008 是一种Hsp70的抑制剂,对Hsp70、Hsc70 和 Grp7 的IC50值分别为 0.5 μM、2.6 μM 和 2.6 μM,对Hsp70的Kd 值为 0.3 μM,比 HSP90 选择性高 100 倍以上。
T5350 JG-98

JG98,JG 98

Apoptosis; HSP Apoptosis; Cytoskeletal Signaling; Metabolism
JG-98 是一种热休克蛋白 70 (Hsp70)变构抑制剂,可与 Hsp70 上的保守位点紧密结合,打断 Hsp70-Bag3 相互作用。它影响癌细胞和肿瘤相关巨噬细胞,具有抗癌活性。
T16994 Pimitespib

TAS-116

HSP Cytoskeletal Signaling; Metabolism
Pimitespib (TAS-116) 是一种 ATP 竞争性和高度特异性的 HSP90α/HSP90β 抑制剂,Ki 值分别为 34.7 nM 和 21.3 nM。
T3293 Apoptozole

Apoptosis Activator VII

Apoptosis; HSP Apoptosis; Cytoskeletal Signaling; Metabolism
Apoptozole (Apoptosis Activator VII) 是一种Hsc70和Hsp70的 ATPase 结构域抑制剂,可诱导凋亡,Kd 值分别为 0.21 和 0.14 μM。
T6284 Onalespib

AT13387,Onalespib (AT13387)

HSP Cytoskeletal Signaling; Metabolism
Onalespib (AT13387) 是一种合成的、口服生物可利用的热休克蛋白 90 (Hsp90) 小分子抑制剂,Kd 值为 0.71 nM。具有潜在的抗肿瘤活性。它选择性地与 Hsp90 结合,从而抑制其伴侣功能并促进参与肿瘤细胞增殖和存活的致癌信号蛋白的降解。
T10860 Col003

HSP Cytoskeletal Signaling; Metabolism
Col003 是一种选择性和有效的 Hsp47 抑制剂,可竞争性结合 Hsp47 上的胶原蛋白结合位点,IC50为1.8 μM。它通过破坏胶原蛋白三螺旋的稳定性来抑制胶原蛋白的分泌,可用于肺纤维化的相关研究。
T9202 DDO-5936

HSP Cytoskeletal Signaling; Metabolism
DDO-5936 是一种特异性Hsp90-Cdc37 PPI 抑制剂,可研究大肠癌。
T8157 Centhaquin

PMZ-2010,Centhaquine

Others Others
Centhaquin (Centhaquine)e 是一种具有研究出血性休克的潜力的试剂。在出血模型中,它能够减少全身血管阻力。
T0756 Ethoxyquin

Santoquin,Quinol,Santoflex,乙氧基喹啉

HSP; Reactive Oxygen Species Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; NF-κB
Ethoxyquin (Santoflex) 是一种热休克蛋白 90 抑制剂,是一种用于动物饲料的抗氧化剂。
T7261 Grp94 Inhibitor-1

GPR; HSP Cytoskeletal Signaling; Endocrinology/Hormones; GPCR/G Protein; Metabolism
Grp94 Inhibitor-1 是一种选择性有效的 Grp94抑制剂,IC50值为 2 nM,是比 Hsp90α 的 1000 倍。
T8901 YUM70

Apoptosis; GPR; HSP Apoptosis; Cytoskeletal Signaling; Endocrinology/Hormones; GPCR/G Protein; Metabolism
YUM70 是一种选择性葡萄糖调节蛋白 78 抑制剂,抑制全长蛋白的 GRP78 ATPase 活性的IC50值为 1.5 μM。它在胰腺癌中诱导内质网应激介导的细胞凋亡。
T7265 HSP27 inhibitor J2

J2

HSP Cytoskeletal Signaling; Metabolism
HSP27 inhibitor J2 (J2) 是一种HSP27抑制剂,可显著增强 17-AAG 的抗增殖活性,并对顺铂诱导的肺癌细胞生长抑制具有敏感性。它显著诱导异常 HSP27 二聚体形成并抑制HSP27巨聚合物的产生,从而具有抑制HSP27的伴侣功能和降低细胞保护功能的作用。
T3454 VER-49009

CCT 129397

HSP Cytoskeletal Signaling; Metabolism
VER-49009 (CCT 129397) 是一种有效的 Hsp90 抑制剂,IC50值为 25 nM,Kd 值为 78 nM。
T2114 VER-82576

NVP-BEP800

HSP Cytoskeletal Signaling; Metabolism
VER-82576 (NVP-BEP800) 是一种可口服的,选择性的 Hsp90抑制剂,对 Hsp90β 的 IC50值为 58 nM,对 Hsp90 家族成员 Trap-1 和 Grp94 的选择性超过 70 倍。
T8958 PU-H54

GPR Endocrinology/Hormones; GPCR/G Protein
PU-H54 是一种基于嘌呤的 Grp94 抑制剂。它是一种基于 Grp94 选择性间苯二酚的抑制剂,通过探测 Grp94 中 S2 亚袋的专有结合区而分离。
T9804 NPX800

CCT361814

HSP Cytoskeletal Signaling; Metabolism
NPX800 是热休克因子 1 (HSF1) 的抑制剂,可用于癌症治疗的相关研究。
T21551 2-hexyl-4-Pentynoic Acid

HDAC Chromatin/Epigenetic; DNA Damage/DNA Repair
2-Hexyl-4-pentynoic acid 是一种丙戊酸 (VPA) 衍生物,可以抑制HDAC(IC50=13 µM) 和诱导HSP70。它可引起培养神经元的组蛋白高度乙酰化,防止谷氨酸诱导的兴奋性毒性,具有强大的神经保护作用。
T2286 BIIB021

BIIB 021,CNF2024,BIIB-021

HSP; Autophagy Autophagy; Cytoskeletal Signaling; Metabolism
BIIB021 (CNF2024) 是一种可口服的合成 HSP90 抑制剂,Ki 值和EC50值分别为 1.7 nM 和 38 nM。
T5152 MKT-077

MKT 077,FJ-776,MKT077

HSP Cytoskeletal Signaling; Metabolism
MKT-077 (FJ-776) 是一种阳离子红花青染料,通过抑制 Hsp70 分子伴侣家族成员的能力,显示出对癌细胞系的抗增殖活性。
T13554 Arimoclomol maleate

BRX-220

HSP Cytoskeletal Signaling; Metabolism
Arimoclomol maleate (BRX-220) 是一种热休克蛋白 (HSP) 的共诱导剂。它通过增强 Hsp 表达来保护运动神经元,进而通过蛋白酶体-泛素系统直接影响蛋白质聚集和错误折叠装配体的清除
T7661 SD-169

SD 169,1H-吲哚-5-甲酰胺

p38 MAPK MAPK
SD-169 (SD 169) 是一种可口服的 ATP 竞争性MAPK p38α抑制剂,IC50值为 3.2 nM。它对p38β MAPK 的IC50值为 122 nM。它通过抑制 T 细胞的浸润和活化阻止糖尿病的发展。
T6609 NMS-E973

HSP Cytoskeletal Signaling; Metabolism
NMS-E973 是一种有效且选择性的 Hsp90 抑制剂,与 Hsp90 结合的 DC50小于 10 nM。它能够穿越血脑屏障,具有抗肿瘤效果。
T6118 NVP-HSP990

HSP990

Apoptosis; HSP Apoptosis; Cytoskeletal Signaling; Metabolism
NVP-HSP990 (HSP990) 是一种选择性的Hsp90抑制剂,对 Hsp90α、Hsp90β 和 Grp94 的IC50值分别为 0.6、0.8 和 8.5 nM。
T12492 Pivagabine

CXB-722,匹伐加宾

GABA Receptor Membrane transporter/Ion channel; Neuroscience
Pivagabine (CXB-722) 是疏水性 4-氨基丁酸的衍生物,具有神经调节活性。它可穿透大鼠的血脑屏障,拮抗足部休克对大鼠脑中 GABAA 受体功能和促肾上腺皮质激素释放因子 (CRF) 浓度的影响。
T2258 VER-50589

VER50589,5-(5-氯-2,4-二羟基苯基)-n-乙基-4-(4-甲氧基苯基)异噁唑-3-羧酰胺

Apoptosis; HSP Apoptosis; Cytoskeletal Signaling; Metabolism
VER-50589 是一种 Hsp90抑制剂,Kd 值为 4.5 nM,IC50值为 21 nM。
T1989 Luminespib

AUY922,VER-52296,NVP-AUY922

Apoptosis; HSP; Autophagy Apoptosis; Autophagy; Cytoskeletal Signaling; Metabolism
Luminespib (VER-52296) 是一种 HSP90抑制剂,抑制 HSP90α 和 HSP90β 的 IC50分别为 7.8 和 21 nM。
T13553 Arimoclomol

阿瑞洛莫,BRX-220 free base

HSP Cytoskeletal Signaling; Metabolism
Arimoclomol (BRX-220 free base) 是热休克蛋白 (HSP) 的共诱导剂,可用于治疗肌萎缩侧索硬化症的研究。
T5593 L-Alanyl-L-glutamine

L-丙氨酰-L-谷氨酰胺,L-丙氨酸-L-谷氨酰胺,Ala-Gln

Others; Endogenous Metabolite Metabolism; Others
L-Alanyl-L-glutamine (Ala-Gln) 是一种由丙氨酸和谷氨酰胺组成的二肽,对抗氧化系统有益,能够减轻炎症,并能够在分解代谢情况下调节热休克蛋白 (HSP) 的反应。
T22419 S-Methylisothiourea sulfate

(S)-Methylisothiourea sulfate,S-甲基异硫脲硫酸盐,S-甲基异硫脲半硫酸盐

NOS; NO Synthase; HSV Immunology/Inflammation; Microbiology/Virology
S-Methylisothiourea sulfate ((S)-Methylisothiourea sulfate) 是一种选择性 iNOS 抑制剂,在感染性休克的啮齿动物模型中发挥有益作用。
T6906 Tamoxifen

ICI 46474,他莫昔芬,Z-Tamoxifen,trans-Tamoxifen,ICI47699

Apoptosis; Estrogen Receptor/ERR; HSP; Estrogen/progestogen Receptor; Autophagy Apoptosis; Autophagy; Cytoskeletal Signaling; Endocrinology/Hormones; Metabolism
Tamoxifen (ICI47699) 是一种雌激素受体调节剂 (SERM),具有选择性和口服有效性。Tamoxifen 对雌激素具有抑制活性 (如乳腺细胞) 和激活活性 (如骨、肝和子宫细胞)。
T6297 Alvespimycin hydrochloride

BMS 826476,NSC 707545,阿螺旋霉素盐酸盐,KOS-1022,17-DMAG hydrochloride,Alvespimycin (17-DMAG) HCl

Apoptosis; HSP Apoptosis; Cytoskeletal Signaling; Metabolism
Alvespimycin hydrochloride (BMS 826476) 是一种Hsp90抑制剂,结合到 Hsp90,EC50为 62±29 nM。
T0835 Tamoxifen Citrate

Tamoxifen Z-isomer citrate,ICI 46474,ICI 46474 Citrate,枸橼酸他莫昔芬,他莫昔芬柠檬酸盐

Apoptosis; Estrogen Receptor/ERR; HSP; Estrogen/progestogen Receptor; Autophagy Apoptosis; Autophagy; Cytoskeletal Signaling; Endocrinology/Hormones; Metabolism
Tamoxifen Citrate 是一种口服有效的,选择性雌激素受体调节剂,可阻断乳腺细胞中的雌激素作用,并可激活如骨骼、肝脏和子宫细胞中的雌激素活性。它是 Hsp90激活剂,可增强 Hsp90 分子伴侣 ATPase 的活性,可激活自噬和诱导凋亡。
T6442 CH5138303

HSP Cytoskeletal Signaling; Metabolism
CH5138303 是一种可口服的 Hsp90 抑制剂,Kd 为 0.48 nM。
T6804 Chetomin

Chaetomin,NSC289491,BRN0077366

Apoptosis; HSP; HIF Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism
Chetomin (BRN0077366) 是球毛壳菌的活性成分,是一种无毒的非小细胞肺癌干细胞靶向分子。它是一种热休克蛋白90/缺氧诱导因子1α 途径的抑制剂。
T6210 Pifithrin-μ

PFTμ,NSC 303580,2-Phenylethynesulfonamide

HSP; p53; Autophagy Apoptosis; Autophagy; Cytoskeletal Signaling; Metabolism
Pifithrin-μ (NSC-303580) 是 p53和 HSP70的抑制剂,具有抗肿瘤和神经保护作用。

化合物

KNK437
Cat.No: T2444
Synonym: Heat Shock Protein Inhibitor I
Target: HSP
Heat Shock Protein Inhibitor II
Cat.No: T36865
Synonym:
Target: Others
ML346
Cat.No: T3594
Synonym:
Target: HSP
HM03
Cat.No: T8668
Synonym:
Target: HSP
HSF1A
Cat.No: T4125
Synonym:
Target: HSP
Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78)
Cat.No: T80964
Synonym:
Target:
XL888
Cat.No: T6248
Synonym:
Target: HSP
HSP70-IN-1
Cat.No: T3487
Synonym:
Target: Others, HSP
DTHIB
Cat.No: T8858
Synonym:
Target: HSP
KW-2478
Cat.No: T6558
Synonym: KW2478
Target: HSP
Teprenone
Cat.No: T5008
Synonym: Tetraprenylacetone,Geranylgeranylacetone,替普瑞酮
Target: HSP
KRIBB11
Cat.No: T3652
Synonym:
Target: Apoptosis, HSP
HA15
Cat.No: T6855
Synonym:
Target: Apoptosis, GPR, Others, HSP, Autophagy
Ganetespib
Cat.No: T2309
Synonym: STA-9090
Target: Apoptosis, HSP, HIF
TRC051384
Cat.No: T3527
Synonym: TRC 051384
Target: HSP
VER-155008
Cat.No: T7010
Synonym: VER155008
Target: GPR, HSP, Autophagy
JG-98
Cat.No: T5350
Synonym: JG98,JG 98
Target: Apoptosis, HSP
Pimitespib
Cat.No: T16994
Synonym: TAS-116
Target: HSP
Apoptozole
Cat.No: T3293
Synonym: Apoptosis Activator VII
Target: Apoptosis, HSP
Onalespib
Cat.No: T6284
Synonym: AT13387,Onalespib (AT13387)
Target: HSP
Col003
Cat.No: T10860
Synonym:
Target: HSP
DDO-5936
Cat.No: T9202
Synonym:
Target: HSP
Centhaquin
Cat.No: T8157
Synonym: PMZ-2010,Centhaquine
Target: Others
Ethoxyquin
Cat.No: T0756
Synonym: Santoquin,Quinol,Santoflex,乙氧基喹啉
Target: HSP, Reactive Oxygen Species
Grp94 Inhibitor-1
Cat.No: T7261
Synonym:
Target: GPR, HSP
YUM70
Cat.No: T8901
Synonym:
Target: Apoptosis, GPR, HSP
HSP27 inhibitor J2
Cat.No: T7265
Synonym: J2
Target: HSP
VER-49009
Cat.No: T3454
Synonym: CCT 129397
Target: HSP
VER-82576
Cat.No: T2114
Synonym: NVP-BEP800
Target: HSP
PU-H54
Cat.No: T8958
Synonym:
Target: GPR
NPX800
Cat.No: T9804
Synonym: CCT361814
Target: HSP
2-hexyl-4-Pentynoic Acid
Cat.No: T21551
Synonym:
Target: HDAC
BIIB021
Cat.No: T2286
Synonym: BIIB 021,CNF2024,BIIB-021
Target: HSP, Autophagy
MKT-077
Cat.No: T5152
Synonym: MKT 077,FJ-776,MKT077
Target: HSP
Arimoclomol maleate
Cat.No: T13554
Synonym: BRX-220
Target: HSP
SD-169
Cat.No: T7661
Synonym: SD 169,1H-吲哚-5-甲酰胺
Target: p38 MAPK
NMS-E973
Cat.No: T6609
Synonym:
Target: HSP
NVP-HSP990
Cat.No: T6118
Synonym: HSP990
Target: Apoptosis, HSP
Pivagabine
Cat.No: T12492
Synonym: CXB-722,匹伐加宾
Target: GABA Receptor
VER-50589
Cat.No: T2258
Synonym: VER50589,5-(5-氯-2,4-二羟基苯基)-n-乙基-4-(4-甲氧基苯基)异噁唑-3-羧酰胺
Target: Apoptosis, HSP
Luminespib
Cat.No: T1989
Synonym: AUY922,VER-52296,NVP-AUY922
Target: Apoptosis, HSP, Autophagy
Arimoclomol
Cat.No: T13553
Synonym: 阿瑞洛莫,BRX-220 free base
Target: HSP
L-Alanyl-L-glutamine
Cat.No: T5593
Synonym: L-丙氨酰-L-谷氨酰胺,L-丙氨酸-L-谷氨酰胺,Ala-Gln
Target: Others, Endogenous Metabolite
S-Methylisothiourea sulfate
Cat.No: T22419
Synonym: (S)-Methylisothiourea sulfate,S-甲基异硫脲硫酸盐,S-甲基异硫脲半硫酸盐
Target: NOS, NO Synthase, HSV
Tamoxifen
Cat.No: T6906
Synonym: ICI 46474,他莫昔芬,Z-Tamoxifen,trans-Tamoxifen,ICI47699
Target: Apoptosis, Estrogen Receptor/ERR, HSP, Estrogen/progestogen Receptor, Autophagy
Alvespimycin hydrochloride
Cat.No: T6297
Synonym: BMS 826476,NSC 707545,阿螺旋霉素盐酸盐,KOS-1022,17-DMAG hydrochloride,Alvespimycin (17-DMAG) HCl
Target: Apoptosis, HSP
Tamoxifen Citrate
Cat.No: T0835
Synonym: Tamoxifen Z-isomer citrate,ICI 46474,ICI 46474 Citrate,枸橼酸他莫昔芬,他莫昔芬柠檬酸盐
Target: Apoptosis, Estrogen Receptor/ERR, HSP, Estrogen/progestogen Receptor, Autophagy
CH5138303
Cat.No: T6442
Synonym:
Target: HSP
Chetomin
Cat.No: T6804
Synonym: Chaetomin,NSC289491,BRN0077366
Target: Apoptosis, HSP, HIF
Pifithrin-μ
Cat.No: T6210
Synonym: PFTμ,NSC 303580,2-Phenylethynesulfonamide
Target: HSP, p53, Autophagy
Cat. No. Product Name Target Signaling Pathways
TQ0280 Feretoside

HSP Cytoskeletal Signaling; Metabolism
Feretoside 是分离自杜仲树皮的一种酚类化合物。它是 HSP 诱导剂,可作为细胞保护剂。
T8189 Dihydroberberine

Potassium Channel; HSP; HER Angiogenesis; Cytoskeletal Signaling; JAK/STAT signaling; Membrane transporter/Ion channel; Metabolism; Tyrosine Kinase/Adaptors
Dihydroberberine 可抑制人类 ether-a-go-go 相关基因 (hERG) 通道并显着降低 Hsp90 表达及其与 hERG 的相互作用,具有抗动脉粥样硬化、抗炎、降血脂和抗肿瘤活性。
T21883 Gedunin

HSP Cytoskeletal Signaling; Metabolism
Gedunin 是从印楝种子中提取的一种重要柠檬苦素,具有抗癌、抗病毒、抗炎和杀虫活性。它可阻断 SARS-CoV-2 病毒进入人宿主细胞,用于 COVID-19 研究。它是Hsp90抑制剂,诱导 Hsp90 依赖的蛋白降解,抑制卵巢癌细胞增殖。
T5826 Eupalinolide A

HSP Cytoskeletal Signaling; Metabolism
Eupalinolide A 是分离于林泽兰中的一种天然产物,通过抑制 HSF1 与 HSP90 的相互作用,激活 HSF1,诱导 HSP70 的表达。它对 A-549、BGC-823、SMMC-7721 和 HL-60 肿瘤细胞系具有强大的细胞毒性。
TN6729 Azadiradione

AZD

Others Others
Azadiradione (AZD) 是 HSF1的一种,是由印楝树中提取得到,具有一定生物活性的柠檬苦素。
T6343 Geldanamycin

格尔德霉素,NSC 122750

HSP; Influenza Virus; Tyrosine Kinases; Antibacterial; Antibiotic Cytoskeletal Signaling; Metabolism; Microbiology/Virology; Tyrosine Kinase/Adaptors
Geldanamycin 是一种 HSP90 抑制剂(Kd:1.2 μM),可特异性破坏糖皮质激素受体 (GR)/HSP 的结合。
TJS0928 Calenduloside E

去葡萄糖竹节参皂苷,Silphioside F

Others Others
Calenduloside E (Silphioside F) 是从辽东楤木中提取的一种五环三萜皂苷。它靶向热休克蛋白90 (Hsp90) ,具有抗凋亡作用。
T8149 Dobutamine hydrochloride

盐酸多巴酚丁胺,Dobutamine (hydrochloride)

Adrenergic Receptor GPCR/G Protein; Neuroscience
Dobutamine hydrochloride (Dobutamine(hydrochloride)) 是一种合成的儿茶酚胺,可作用于肾上腺素能受体α1-AR、β1-AR 和β2-AR,是一种选择性的 β1-AR 受体激动剂,对 α1-AR 和 β2-AR 作用相对较弱。它能够增加心输出量,矫正低灌注。
T2230 Paeoniflorin

芍药苷,Peoniflorin

HSP; COX Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; Neuroscience
Paeoniflorin (Peoniflorin) 是从芍药根中提取的一种蒎烷单萜糖苷,具有抗癌作用、抗氧化应激、抗血小板聚集、血管扩张、降低血液粘度和抗炎活性等多种生物活性。它是一种热休克蛋白诱导剂,通过自噬途径保护 PC12 细胞免受 MPP+和酸性损伤。
TQ0131 Rocaglamide

Rocaglamide A,楝酰胺,Roc-A

HSP; NF-κB; PERK Apoptosis; Cytoskeletal Signaling; Metabolism; NF-κB
Rocaglamide (Roc-A) 是从米仔兰中分离出来的一种天然产物,具有抗癌特性,可用于咳嗽,受伤,哮喘和炎症性皮肤病。它是一种有效的选择性热休克因子 1 活化抑制剂,IC50约为 50 nM。它是 T 细胞中 NF-κB 活化的有效抑制剂,还抑制翻译起始因子eIF4A 的功能。
T2908 Palmitic acid

Hexadecoic acid,hexadecanoic acid,棕榈酸,Cetylic acid

HSP; Endogenous Metabolite Cytoskeletal Signaling; Metabolism
Palmitic acid (Cetylic acid) 属于天然产物,是一种常见的饱和脂肪酸,在动物、植物和微生物中均存在。Palmitic acid 具有抗肿瘤活性。
T0974 Novobiocin Sodium

Albamycinsodium,新生霉素钠,Cathomycin,Albamycin

Potassium Channel; DNA gyrase; Topoisomerase; Antibacterial; Antibiotic; ABC; Autophagy Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology
Novobiocin Sodium (Albamycinsodium) 是源自 Streptomyces niveus 的抗生素。 它的化学结构类似于香豆素。Novobiocin 与 DNA 促旋酶结合并阻断三磷酸腺苷活性。
T6290 Tanespimycin

坦螺旋霉素,17-AAG,CP 127374,NSC 330507,KOS 953

Apoptosis; Mitophagy; HSP; Antibacterial; Antibiotic; Autophagy Apoptosis; Autophagy; Cytoskeletal Signaling; Metabolism; Microbiology/Virology
Tanespimycin (KOS 953) 是一种 Hsp90 抑制剂,可选择性抑制 BT474 肿瘤细胞 Hsp90,IC50为 5 nM。它消耗细胞内 STK38/NDR1,并降低 STK38 激酶活性,还能下调stk38基因表达。
T8304 Anisodamine Hydrobromide

6-Hydroxyhyoscyamine,氢溴酸山莨菪碱

Adrenergic Receptor; AChR GPCR/G Protein; Neuroscience
Anisodamine Hydrobromide (6-Hydroxyhyoscyamine) 是来自颠茄的一种生物碱,具有抗氧化、抗炎活性。它也是一种非亚型的选择性毒蕈碱和烟碱类胆碱受体拮抗剂。
T0970 Racanisodamine

山莨菪碱,Anisodamine,7β-Hydroxyhyoscyamine,Raceanisodamine,消旋山莨菪碱

Adrenergic Receptor; AChR GPCR/G Protein; Neuroscience
Racanisodamine (7β-Hydroxyhyoscyamine) 是 anisodamine 的消旋体,是非选择性的毒蕈碱拮抗剂,是近视控制滴眼液的有效成分。
T6662 Scopine

东莨菪醇,6,7-Epoxytropine

Adrenergic Receptor GPCR/G Protein; Neuroscience
Scopine (6,7-Epoxytropine) 是一种山莨菪碱的代谢物,是一种 α1-肾上腺素受体激动剂,用于治疗急性循环性休克。
T21532 Anisodamine

6-Hydroxyhyoscyamine,6-beta-Hydroxyhyoscyamine

AChR Neuroscience
Anisodamine (6-beta-Hydroxyhyoscyamine) 是毒蕈碱和烟碱胆碱受体的拮抗剂,对毒蕈碱受体的亲和力与东莨菪碱和阿托品相似。 Anisodamine 改善休克状态下的微循环,可用于有机磷中毒的研究。
TN6774 Emodin 6-O-β-D-glucoside

大黄素-6-O-β-D-葡萄糖苷,Glucoemodin

Others Others
Emodin 6-O-β-D-glucoside (Glucoemodin) 是一种从 Reynoutria japonica 中提取的活性化合物。它具有显著的抗炎和屏障保护活性,可用于研究动脉粥样硬化及糖尿病并发症。
T4904 1-Methylguanidine hydrochloride

Others; Endogenous Metabolite Metabolism; Others
1-Methylguanidine hydrochloride 是内源性代谢产物的一种。
T2174 Quercetin

槲皮素,Sophoretin

Apoptosis; Mitophagy; Reactive Oxygen Species; PI3K; Autophagy Apoptosis; Autophagy; Immunology/Inflammation; Metabolism; NF-κB; PI3K/Akt/mTOR signaling
Quercetin 属于黄酮类天然产物,是 SIRT1 的激动剂;Quercetin 也是一种 PI3K 抑制剂,抑制 PI3Kγ、PI3Kδ 和 PI3Kβ (IC50=2.4/3.0/5.4 μM)。Quercetin 作为公认的热休克蛋白抑制剂,也可通过下调Hsp70或Hsp90来显著减少TII模型中的外泌体释放。
T4839 Ac-Ala-OH

N-Acetylalanine,N-Acetyl-L-alanine,N-乙酰-L-丙氨酸

Others; Endogenous Metabolite Metabolism; Others
Ac-Ala-OH (N-Acetyl-L-alanine) 是鸟嘌呤核苷酸结合蛋白G(I)/G(S)/G(O) γ -2亚基、髓鞘碱性蛋白、GTP-结合核蛋白 Ran、原肌球蛋白 α - 4链、HIV-1 Rev 结合蛋白2、Xaa-Pro 二肽酶、胸腺酶 β -10、肌动蛋白样蛋白3、丙氨酸转氨酶、丝氨酸/苏氨酸蛋白磷酸酶PP1 - β催化亚基、10 kda 热休克蛋白(线粒体)、钙调蛋白和 β -1-syntrophin 的底物。
T4S0350 Licochalcone B

甘草查尔酮 B,甘草查尔酮B

Beta Amyloid; Others Neuroscience; Others
Licochalcone B 是从Glycyrrhiza inflate 根中提取的。它能够抑制淀粉样蛋白 β 自聚集作用 (IC50=2.16 μM) ,分解预先形成的 Aβ42原纤维,并通过螯合金属离子抑制金属诱导的 Aβ42聚集。
T3729 Ethyl gallate

Nipagallin A,Phyllemblin,gallic acid ethyl ester,没食子酸乙酯

MMP; NF-κB; Akt; Antibacterial Cytoskeletal Signaling; Microbiology/Virology; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome
Ethyl gallate (gallic acid ethyl ester) 是一种非类黄酮酚过氧化氢清除剂。
TN3572 Calyxin H

HSP Cytoskeletal Signaling; Metabolism
Calyxin H at 1uM can increase the expression of heat shock factor 1 (HSF1), it has a possible application as a heat shock protein (HSP) inducer.
T5136 Kongensin A

Kongensin A is an effective heat shock protein 90 (HSP90) inhibitor that has potential anti-necroptosis and anti-inflammation applications.
T10034 (R)-10,11-Dehydrocurvularin

10,11-Dehydrocurvularin

Others Others
10,11-Dehydrocurvularin is an antibiotic and a strong activator of the heat shock response. It inhibits the TGF-β signaling pathway and has anti-tumorous activity.
TN4013 Esculentic acid

IL Receptor; TNF; COX Apoptosis; Immunology/Inflammation; Neuroscience
Esculentic acid has anti-inflammatory effect, it has protective effects against LPS-induced endotoxic shock may be mediated, at least in part, by regulation the release of inflammatory cytokines and mediators, and protein expression of COX-2 in mice.
TN3839 Desoxo-narchinol A

ERK; IL Receptor; p38 MAPK; TNF; NOS; NF-κB; COX; Prostaglandin Receptor; JNK Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK; Neuroscience; NF-κB
Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity against LPS-induced NO production. Desoxo-narchinol A shows cytotoxic activity against P-388 cells.
T75533 Dihydromaniwamycin E

Others Others
Dihydromaniwamycin E 是一种热休克代谢物,对influenza 和SARS-CoV-2病毒具有抗病毒活性。
TN3366 Ailanthoidol

IL Receptor; NOS; COX; Prostaglandin Receptor; PPAR DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience
Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potential as a chemopreventive agent against tumor promotion. Ailanthoidol has anti-adipogenic activit
TN6613 Delphinidin-3-O-galactoside chloride

Delphinidin-3-O-galactoside chloride has anti-obesity and hypolipidemic effects. Delphinidin-3-O-galactoside (D3G) is a water-soluble anthocyanin with antioxidant activity. D3G is capable of masking the EGCG-induced cytotoxicity and ER stress, presumably
T83319 4-epi-Withaferin A

4-epi-Withaferin A(化合物28)是Withaferin A的一个类似物,它增强了细胞毒性及细胞保护性热休克诱导活性(HSA)。此外,4-epi-Withaferin A还展现了通过激活细胞防御机制来研究蛋白质聚集相关疾病的潜力。

天然产物

Feretoside
Cat.No: TQ0280
Synonym:
Target: HSP
Dihydroberberine
Cat.No: T8189
Synonym:
Target: Potassium Channel, HSP, HER
Gedunin
Cat.No: T21883
Synonym:
Target: HSP
Eupalinolide A
Cat.No: T5826
Synonym:
Target: HSP
Azadiradione
Cat.No: TN6729
Synonym: AZD
Target: Others
Geldanamycin
Cat.No: T6343
Synonym: 格尔德霉素,NSC 122750
Target: HSP, Influenza Virus, Tyrosine Kinases, Antibacterial, Antibiotic
Calenduloside E
Cat.No: TJS0928
Synonym: 去葡萄糖竹节参皂苷,Silphioside F
Target: Others
Dobutamine hydrochloride
Cat.No: T8149
Synonym: 盐酸多巴酚丁胺,Dobutamine (hydrochloride)
Target: Adrenergic Receptor
Paeoniflorin
Cat.No: T2230
Synonym: 芍药苷,Peoniflorin
Target: HSP, COX
Rocaglamide
Cat.No: TQ0131
Synonym: Rocaglamide A,楝酰胺,Roc-A
Target: HSP, NF-κB, PERK
Palmitic acid
Cat.No: T2908
Synonym: Hexadecoic acid,hexadecanoic acid,棕榈酸,Cetylic acid
Target: HSP, Endogenous Metabolite
Novobiocin Sodium
Cat.No: T0974
Synonym: Albamycinsodium,新生霉素钠,Cathomycin,Albamycin
Target: Potassium Channel, DNA gyrase, Topoisomerase, Antibacterial, Antibiotic, ABC, Autophagy
Tanespimycin
Cat.No: T6290
Synonym: 坦螺旋霉素,17-AAG,CP 127374,NSC 330507,KOS 953
Target: Apoptosis, Mitophagy, HSP, Antibacterial, Antibiotic, Autophagy
Anisodamine Hydrobromide
Cat.No: T8304
Synonym: 6-Hydroxyhyoscyamine,氢溴酸山莨菪碱
Target: Adrenergic Receptor, AChR
Racanisodamine
Cat.No: T0970
Synonym: 山莨菪碱,Anisodamine,7β-Hydroxyhyoscyamine,Raceanisodamine,消旋山莨菪碱
Target: Adrenergic Receptor, AChR
Scopine
Cat.No: T6662
Synonym: 东莨菪醇,6,7-Epoxytropine
Target: Adrenergic Receptor
Anisodamine
Cat.No: T21532
Synonym: 6-Hydroxyhyoscyamine,6-beta-Hydroxyhyoscyamine
Target: AChR
Emodin 6-O-β-D-glucoside
Cat.No: TN6774
Synonym: 大黄素-6-O-β-D-葡萄糖苷,Glucoemodin
Target: Others
1-Methylguanidine hydrochloride
Cat.No: T4904
Synonym:
Target: Others, Endogenous Metabolite
Quercetin
Cat.No: T2174
Synonym: 槲皮素,Sophoretin
Target: Apoptosis, Mitophagy, Reactive Oxygen Species, PI3K, Autophagy
Ac-Ala-OH
Cat.No: T4839
Synonym: N-Acetylalanine,N-Acetyl-L-alanine,N-乙酰-L-丙氨酸
Target: Others, Endogenous Metabolite
Licochalcone B
Cat.No: T4S0350
Synonym: 甘草查尔酮 B,甘草查尔酮B
Target: Beta Amyloid, Others
Ethyl gallate
Cat.No: T3729
Synonym: Nipagallin A,Phyllemblin,gallic acid ethyl ester,没食子酸乙酯
Target: MMP, NF-κB, Akt, Antibacterial
Calyxin H
Cat.No: TN3572
Synonym:
Target: HSP
Kongensin A
Cat.No: T5136
Synonym:
Target:
(R)-10,11-Dehydrocurvularin
Cat.No: T10034
Synonym: 10,11-Dehydrocurvularin
Target: Others
Esculentic acid
Cat.No: TN4013
Synonym:
Target: IL Receptor, TNF, COX
Desoxo-narchinol A
Cat.No: TN3839
Synonym:
Target: ERK, IL Receptor, p38 MAPK, TNF, NOS, NF-κB, COX, Prostaglandin Receptor, JNK
Dihydromaniwamycin E
Cat.No: T75533
Synonym:
Target: Others
Ailanthoidol
Cat.No: TN3366
Synonym:
Target: IL Receptor, NOS, COX, Prostaglandin Receptor, PPAR
Delphinidin-3-O-galactoside chloride
Cat.No: TN6613
Synonym:
Target:
4-epi-Withaferin A
Cat.No: T83319
Synonym:
Target:
Cat. No. Product Name Species Expression System
TMPY-01478 HSP90 alpha Protein, Human, Recombinant

Hsp89,Hsp90,HSPCAL1,heat shock protein 90kDa alpha ...

Human E. coli
HSP90 alpha Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 22.6 kDa and the accession number is K9JA46.
TMPH-03446 SSA1 Protein, S. cerevisiae, Recombinant (His & Myc)

Heat shock protein YG100,Heat shock protei...

Saccharomyces cerevisiae E. coli
May play a role in the transport of polypeptides both across the mitochondrial membranes and into the endoplasmic reticulum. A functional difference between SSA1 and SSA2 proteins is expected. SSA1 can participate in the ATP-dependent disassembly of clathrin-coated vesicles. SSA1 Protein, S. cerevisiae, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 28.3 kDa and the accession number is P10591.
TMPH-01430 HSP90AB1 Protein, Human, Recombinant (His & Myc)

Heat shock protein HSP 90-beta,HSP90AB1,Heat sh...

Human E. coli
HSP90AB1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 88.1 kDa and the accession number is P08238.
TMPH-03721 IbpA Protein, Yersinia pestis bv. Antiqua, Recombinant (His)

Small heat shock protein IbpA,16 kDa heat shock...

Yersinia pestis E. coli
Associates with aggregated proteins, together with IbpB, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent.
TMPY-06092 HSP70 Protein, Rat, Recombinant (His)

heat shock 70kDa protein 1A

Rat HEK293 Cells
HSP70 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.6 kDa and the accession number is A6KTP2.
TMPH-03467 CspA Protein, Salmonella enteritidis, Recombinant (His & Myc)

CS7.4,CSP-A,cspA,Cold shock protein CspA,7.4 kDa co...

Salmonella enteritidis E. coli
Binds to and stimulates the transcription of the CCAAT-containing, cold-shock-inducible promoters of the H-NS and GyrA proteins. Binds also to the inverted repeat 5'-ATTGG-3'. CspA Protein, Salmonella enteritidis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 14.7 kDa and the accession number is P0A9Y5.
TMPH-00094 HSP21, chloroplastic Protein, Arabidopsis thaliana, Recombinant (His & Myc)

25.3 kDa heat shock protein, chloroplastic,HSP21,He...

Arabidopsis thaliana E. coli
Chaperone protein required for seedling and chloroplast development under heat stress, probably by maintaining plastid-encoded RNA polymerase (PEP)-dependent transcription. HSP21, chloroplastic Protein, Arabidopsis thaliana, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 28.4 kDa and the accession number is P31170.
TMPH-00371 HSP70 Protein, Chicken, Recombinant (His)

Heat shock 70 kDa protein

Chicken E. coli
HSP70 Protein, Chicken, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 48.6 kDa and the accession number is P08106.
TMPH-00765 HSP70 Protein, Gallus gallus, Recombinant (His & Myc)

Heat shock 70 kDa protein

Chicken Baculovirus Insect Cells
HSP70 Protein, Gallus gallus, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 46.5 kDa and the accession number is P08106.
TMPY-02072 HSF1 Protein, Human, Recombinant (His)

HSTF1,heat shock transcription factor 1

Human E. coli
Heat shock factor protein 1, also known as heat shock transcription factor 1, HSF1, and HSTF1, is a cytoplasm and nucleus protein that belongs to the HSF family. HSF1 is the major transcription factor of HSPs (heat shock proteins) in response to various stresses. Wild type HSF1 (heat shock transcriptional factor 1) is normally inactive. HSF1 / HSTF1 is a DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable...
TMPH-00592 DnaK Protein, E. coli, Recombinant (His)

Chaperone protein DnaK,dnaK,Heat shock protein 70,H...

E. coli E. coli
Acts as a chaperone.
TMPH-00593 DnaK Protein, E. coli, Recombinant (Yeast, His)

HSP70,Heat shock protein 70,Heat shock 70 ...

E. coli P. pastoris (Yeast)
Acts as a chaperone.
TMPJ-01080 HSF2 Protein, Human, Recombinant (His)

HSF 2,Heat Shock Factor Protein 2,HSF2,HSTF2,Heat <...

Human E. coli
Heat Shock Factor Protein 2 (HSF2) belongs to the HSF family of transcription factors that bind specifically to the heat-shock promoter element and activate transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked. HSF2 is widely expressed in many cells and tissues. HSF2 is located on Cytoplasmic during normal growth. But when it is activited, HSF2 moves to the nucleus.
TMPH-03579 TSST-1 Protein, S. aureus, Recombinant (His & SUMO)

Toxic shock syndrome toxin-1,tst

Staphylococcus aureus E. coli
Responsible for the symptoms of toxic shock syndrome. TSST-1 Protein, S. aureus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 37.9 kDa and the accession number is P06886.
TMPH-00594 HtpG Protein, E. coli, Recombinant (His)

Chaperone protein HtpG,Heat shock protein C62.5,Hea...

E. coli E. coli
Molecular chaperone. Has ATPase activity.
TMPJ-01411 HSPB11 Protein, Human, Recombinant (His)

PP25,Placental Protein 25,Heat Shock Protein β-11,H...

Human E. coli
Heat Shock Protein β-11 (HSPB11) is a stress-responsive protein that is required to deal with proteotoxic stresses. HSPB11 is composed of an IFT complex B composed of IFT88, IFT57, TRAF3IP1, IFT52, IFT27, HSPB11 and IFT20 and is detected in placenta. HSPB11 has beeb shown to form oligomeric complexes and prevent the aggregation of in vitro denaturated aldolase and glyceraldehyde-3-phosphate dehydrogenase in accordance with the chaperone model of HSPB1 and HSPB5. HSPB11 overexpression protected a...
TMPY-01924 HSP60 Protein, Mouse, Recombinant (His)

heat shock 60kDa protein 1 (chaperonin),Hsp60,60kDa

Mouse E. coli
HSP60 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 62.3 kDa and the accession number is P63038-1.
TMPH-00595 HtpG Protein, E. coli, Recombinant

High temperature protein G,Heat shock protein C62.5...

E. coli E. coli
Molecular chaperone. Has ATPase activity.
TMPH-03636 HSP70 Protein, Toxoplasma gondii, Recombinant (His)

HSP70,Heat shock 70 kDa protein

Toxoplasma gondii E. coli
N/A. HSP70 Protein, Toxoplasma gondii, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 78.9 kDa and the accession number is A0A125YXI9.
TMPH-01427 HSPA8 Protein, Human, Recombinant (His)

Lipopolysaccharide-associated protein 1,HSPA8,Heat shock...

Human P. pastoris (Yeast)
HSPA8 Protein, Human, Recombinant (His) is expressed in Yeast.
TMPH-03649 HSP100 Protein, Trypanosoma cruzi, Recombinant (His & Myc)

Heat shock protein 100,HSP100,Protein CLP

Trypanosoma cruzi E. coli
N/A. HSP100 Protein, Trypanosoma cruzi, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 22.9 kDa and the accession number is O15885.
TMPH-03113 HSP90AA1 Protein, Pig, Recombinant (His)

HSP90AA1,Heat shock protein HSP 90-alpha

Sus scrofa (Pig) Baculovirus Insect Cells
HSP90AA1 Protein, Pig, Recombinant (His) is expressed in Baculovirus insect cells with N-6xHis tag. The predicted molecular weight is 19.7 kDa and the accession number is O02705.
TMPH-00071 AtHsp23.6 Protein, Arabidopsis thaliana, Recombinant (His)

23.6 kDa heat shock protein, mitochondrial,AtHsp23....

Arabidopsis thaliana E. coli
AtHsp23.6 Protein, Arabidopsis thaliana, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 24.4 kDa and the accession number is Q96331.
TMPH-01429 HSP90AA1 Protein, Human, Recombinant (His)

Lipopolysaccharide-associated protein 2,Heat shock ...

Human E. coli
HSP90AA1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 36.0 kDa and the accession number is P07900.
TMPJ-00754 CRYAA Protein, Human, Recombinant (His)

Heat Shock Protein Beta-4,CRYA1,α-Crystallin A Chai...

Human E. coli
Alpha-Crystallin A Chain (CRYAA) belongs to the small heat shock protein (HSP20) family and can be induced by heat shock. The expression of CRYAA is preferentially restricted to the lens cell. CRYAA may contribute to the transparency and refractive index of the lens. CRYAA has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Two additional functions of CRYAA are an autokinase activity and participation in the intracellular architecture.
TMPH-00466 HSP90AA1 Protein, Danio rerio, Recombinant (His & Myc)

Heat shock protein HSP 90-alpha 1,hsp90a.1

Danio rerio (Zebrafish) Baculovirus Insect Cells
HSP 90-alpha 1 Protein, Danio rerio, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 27.9 kDa and the accession number is Q90474.
TMPY-06091 HSP70 Protein, Mouse, Recombinant (His)

Hsp70-3,Hsp72,hsp68,hsp70A1,heat shock 70kDa protei...

Mouse HEK293 Cells
HSP70 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.5 kDa and the accession number is Q3TU85.
TMPY-04804 Cpn10/HSPE1 Protein, Human, Recombinant (His)

GROES,heat shock 10kDa protein 1,EPF,HSP10,CPN10

Human E. coli
Cpn10/HSPE1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 13.2 kDa and the accession number is A0A384N6A4.
TMPH-03133 HSP18.1 Protein, Pisum sativum, Recombinant (His & SUMO)

18.1 kDa class I heat shock protein,HSP 18.1,HSP18....

Pisum sativum E. coli
N/A. HSP18.1 Protein, Pisum sativum, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 34.1 kDa and the accession number is P19243.
TMPH-00708 DegP Protein, E. coli, Recombinant (His)

Periplasmic serine endoprotease DegP,Heat shock pro...

E. coli P. pastoris (Yeast)
DegP acts as a chaperone at low temperatures but switches to a peptidase (heat shock protein) at higher temperatures. Degrades transiently denatured and unfolded or misfolded proteins which accumulate in the periplasm following heat shock or other stress conditions. DegP is efficient with Val-Xaa and Ile-Xaa peptide bonds, suggesting a preference for beta-branched side chain amino acids. Only unfolded proteins devoid of disulfide bonds appear capable of being cleaved, thereby preventing non-spec...
TMPJ-00915 HSP40 Protein, Human, Recombinant (His)

HDJ1,HSPF1,DNAJ1,Heat Shock 40 kDa Protein 1,HSP40,...

Human E. coli
DnaJ Homolog Subfamily B Member 1 (DNAJB1) is a member of the heat shock protein family. Heat shock proteins (HSPs) are a highly conserved family of stress response proteins. HSPs function primarily as molecular chaperones, facilitating the folding of other cellular proteins, preventing protein aggregation, or targeting improperly folded proteins to specific degradative pathways. DNAJB1 regulates cellular processes by aiding in the folding, transport and assembly. DNAJB1 contains a J-domain whic...
TMPH-00189 HtpG Protein, Bacteroides fragilis, Recombinant (His & Myc & SUMO)

Chaperone protein HtpG,Heat shock protein HtpG,htpG...

Bacteroides fragilis E. coli
Molecular chaperone. Has ATPase activity. HtpG Protein, Bacteroides fragilis, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 57.0 kDa and the accession number is Q5LCH4.
TMPJ-01372 Cornulin Protein, Human, Recombinant (His)

Tumor-Related Protein,58 kDa Heat Shock Protein,PDR...

Human E. coli
Cornulin is a member of the fused gene family of molecular chaperones. Human Cornulin contains N-terminus EF-hand domains and Ca2+ binding domains, and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. Cornulin involves in the mucosal/epithelial immune response and epidermal differentiation. Cornulin is a survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and ...
TMPH-02638 HSPA5 Protein, Mouse, Recombinant (E. coli, His)

Hspa5,Heat shock protein 70 family protein 5,Endopl...

Mouse E. coli
Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate. Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ER...
TMPH-02639 HSPA5 Protein, Mouse, Recombinant (His)

78 kDa glucose-regulated protein,Immunoglobulin heavy chain-...

Mouse P. pastoris (Yeast)
HSPA5 Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 72.5 kDa and the accession number is P20029.
TMPH-00887 AHSA1 Protein, Human, Recombinant (GST)

C14orf3,p38,Activator of 90 kDa heat shock protein ...

Human E. coli
Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. AHSA1 Protein, Human, Recombinant (GST) is expressed i...
TMPJ-01382 HSPB8 Protein, Human, Recombinant (His)

Small stress protein-like protein HSP22,CRYAC,E2IG1,Alpha-cr...

Human E. coli
Heat shock protein beta-8 (HSPB8) belongs to the small heat shock protein (HSP20) family. This protein can be inducted by 17-beta-estradiol, and is predominantly expressed in skeletal muscle and heat, mainly located in the cytoplasm and nucleus. HSPB8 usually exists in monomer, it can interact with HSPB1 and DNAJB6. HSPB8 displays temperature-dependent chaperone activity,appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have bee...
TMPY-06846 HSP90 alpha Protein, Mouse, Recombinant (His)

AL024080,Hspca,hsp4,Hsp86-1,heat shock protein 90kD...

Mouse Baculovirus Insect Cells
HSP90 alpha Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 87.19 kDa and the accession number is NP_032328.2.
TMPJ-00755 CRYAB Protein, Human, Recombinant (His)

α(B)-Crystallin,Alpha(B)-Crystallin,Heat Shock Prot...

Human E. coli
α Crystallin B Chain (CRYAB) is a cytoplasmic protein that belongs to the small heat shock protein (HSP20) family. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. Alpha crystallins acts as molecular chaperones and hold them in in large soluble aggregates. CRYAB is expressed widely in many tissues and or...
TMPY-01876 HSP60 Protein, Human, Recombinant (His & GST)

GROEL,HSP60,HLD4,HSP-60,CPN60,SPG13,HSP65,HuCHA60,heat s...

Human E. coli
HSP60 Protein, Human, Recombinant (His & GST) is expressed in E. coli expression system with His and GST tag. The predicted molecular weight is 88.7 kDa and the accession number is A0A024R3X4.
TMPY-02443 HSP70 Protein, Human, Recombinant (His)

heat shock 70kDa protein 1A,HSP70-1,HSP70I,HSP70-1A...

Human Baculovirus Insect Cells
HSP70 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 72.2 kDa and the accession number is A8K5I0.
TMPH-00729 RpoH Protein, E. coli, Recombinant (His & Myc)

RNA polymerase sigma-32 factor,Heat shock regulator...

E. coli E. coli
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. Intracellular concentration of free RpoH protein increases in response to heat shock, which causes association with RNA polymerase (RNAP) and initiation of transcription of heat shock genes, including numerous global transcriptional regulators and genes involved in maintaining membrane...
TMPH-01428 TRAP1 Protein, Human, Recombinant (GST)

TNFR-associated protein 1,Tumor necrosis factor type 1 recep...

Human E. coli
Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. TRAP1 Protein, Human, Recombinant (GST) is expressed in E. coli expressi...
TMPY-06845 HSP90 alpha Protein, Human, Recombinant (His)

EL52,HSP89A,heat shock protein 90kDa alpha (cytosol...

Human Baculovirus Insect Cells
HSP90 alpha Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 87.06 kDa and the accession number is NP_005339.3.
TMPY-02217 HSC70 Protein, Human, Recombinant (His)

HSP73,HSC54,HSP71,NIP71,LAP-1,HEL-33,HSPA10,HSC71,LAP1,HEL-S...

Human E. coli
HSPA8, also known as HSC70, is a member of the heat shock protein family due to homology with other heat shock proteins. The heat shock protein 70 family is comprised of both heat-inducible and constitutively expressed members. The latter are called heat-shock cognate proteins. HSPA8 belongs to the heat-shock cognate subgroup. Members of the human heat-shock protein multigene family have several highly conserved proteins with structural and functional properties in common but vary in the extent ...
TMPJ-00995 Serpin H1 Protein, Human, Recombinant (His)

Arsenic-Transactivated Protein 3,SERPINH2,Rheumatoid Arthrit...

Human HEK293 Cells
Serpin H1 is a serine proteinase inhibitors Which belongs to the serpin family. Serpin H1 is induced by heat shock. Serpin H1 localizes to the endoplasmic reticulum lumen and binds specifically to collagen. Thus it is thought to be a molecular chaperone involved in the maturation of collagen molecules. Autoantibodies to this protein have been found in patients with rheumatoid arthritis. Serpin H1 may be a marker for cancer and nucleotide polymorphisms in this gene may be associated with preterm ...
TMPH-01285 EEF1D Protein, Human, Recombinant (His)

Elongation factor 1-delta,EF1D,EF-1-delta,EEF1D,Antigen NY-C...

Human E. coli
EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.; Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE).
TMPK-00693 HSP27/HSPB1 Protein, Human, Recombinant (His)

Hsp27,SRP27,HMN2B,HSP 27,HSPB1,CMT2F,HSP28

Human E. coli
Heat shock protein beta-1 (HSPB1, also known as HSP27) is a small heat shock protein involved in many cellular processes and reportedly protects cells against oxidative stress. This protein is expressed only in insulin-dependent tissues (heart, skeletal muscle, and fat tissue), and expression of HspB7 is regulated by many different factors. HspB7 has an unusual N-terminal sequence, a conservative α-crystallin domain, and very short C-terminal domain lacking conservative IPV tripeptide involved i...
TMPK-00015 Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi)

GROES,Hsp10,Chaperonin 10,HSPE1,EPF,CPN10

Human,Mouse,Goat E. coli
Cpn10/HSPE, a 10-kDa heat shock protein, is a novel interacting partner of NPAT. A pool of Cpn10 is colocalized with NPAT foci during G1 and S phases in nuclei.Cpn10 is important for S phase progression and cell proliferation. Interaction of Heat Shock Protein Cpn10 with the Cyclin E/Cdk2 Substrate Nuclear Protein Ataxia-Telangiectasia (NPAT) Is Involved in Regulating Histone Transcription. Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi) is expressed in E. coli expression system w...
TMPK-00016 Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi), Biotinylated

Hsp10,Chaperonin 10,HSPE1,GROES,EPF,Cpn10

Human,Mouse,Goat E. coli
Cpn10/HSPE, a 10-kDa heat shock protein, is a novel interacting partner of NPAT. A pool of Cpn10 is colocalized with NPAT foci during G1 and S phases in nuclei.Cpn10 is important for S phase progression and cell proliferation. Interaction of Heat Shock Protein Cpn10 with the Cyclin E/Cdk2 Substrate Nuclear Protein Ataxia-Telangiectasia (NPAT) Is Involved in Regulating Histone Transcription. Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi), Biotinylated is expressed in E. coli expre...
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重组蛋白

HSP90 alpha Protein, Human, Recombinant
Cat.No: TMPY-01478
Species: Human
Expression System: E. coli
SSA1 Protein, S. cerevisiae, Recombinant (His & Myc)
Cat.No: TMPH-03446
Species: Saccharomyces cerevisiae
Expression System: E. coli
HSP90AB1 Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-01430
Species: Human
Expression System: E. coli
IbpA Protein, Yersinia pestis bv. Antiqua, Recombinant (His)
Cat.No: TMPH-03721
Species: Yersinia pestis
Expression System: E. coli
HSP70 Protein, Rat, Recombinant (His)
Cat.No: TMPY-06092
Species: Rat
Expression System: HEK293 Cells
CspA Protein, Salmonella enteritidis, Recombinant (His & Myc)
Cat.No: TMPH-03467
Species: Salmonella enteritidis
Expression System: E. coli
HSP21, chloroplastic Protein, Arabidopsis thaliana, Recombinant (His & Myc)
Cat.No: TMPH-00094
Species: Arabidopsis thaliana
Expression System: E. coli
HSP70 Protein, Chicken, Recombinant (His)
Cat.No: TMPH-00371
Species: Chicken
Expression System: E. coli
HSP70 Protein, Gallus gallus, Recombinant (His & Myc)
Cat.No: TMPH-00765
Species: Chicken
Expression System: Baculovirus Insect Cells
HSF1 Protein, Human, Recombinant (His)
Cat.No: TMPY-02072
Species: Human
Expression System: E. coli
DnaK Protein, E. coli, Recombinant (His)
Cat.No: TMPH-00592
Species: E. coli
Expression System: E. coli
DnaK Protein, E. coli, Recombinant (Yeast, His)
Cat.No: TMPH-00593
Species: E. coli
Expression System: P. pastoris (Yeast)
HSF2 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01080
Species: Human
Expression System: E. coli
TSST-1 Protein, S. aureus, Recombinant (His & SUMO)
Cat.No: TMPH-03579
Species: Staphylococcus aureus
Expression System: E. coli
HtpG Protein, E. coli, Recombinant (His)
Cat.No: TMPH-00594
Species: E. coli
Expression System: E. coli
HSPB11 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01411
Species: Human
Expression System: E. coli
HSP60 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-01924
Species: Mouse
Expression System: E. coli
HtpG Protein, E. coli, Recombinant
Cat.No: TMPH-00595
Species: E. coli
Expression System: E. coli
HSP70 Protein, Toxoplasma gondii, Recombinant (His)
Cat.No: TMPH-03636
Species: Toxoplasma gondii
Expression System: E. coli
HSPA8 Protein, Human, Recombinant (His)
Cat.No: TMPH-01427
Species: Human
Expression System: P. pastoris (Yeast)
HSP100 Protein, Trypanosoma cruzi, Recombinant (His & Myc)
Cat.No: TMPH-03649
Species: Trypanosoma cruzi
Expression System: E. coli
HSP90AA1 Protein, Pig, Recombinant (His)
Cat.No: TMPH-03113
Species: Sus scrofa (Pig)
Expression System: Baculovirus Insect Cells
AtHsp23.6 Protein, Arabidopsis thaliana, Recombinant (His)
Cat.No: TMPH-00071
Species: Arabidopsis thaliana
Expression System: E. coli
HSP90AA1 Protein, Human, Recombinant (His)
Cat.No: TMPH-01429
Species: Human
Expression System: E. coli
CRYAA Protein, Human, Recombinant (His)
Cat.No: TMPJ-00754
Species: Human
Expression System: E. coli
HSP90AA1 Protein, Danio rerio, Recombinant (His & Myc)
Cat.No: TMPH-00466
Species: Danio rerio (Zebrafish)
Expression System: Baculovirus Insect Cells
HSP70 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-06091
Species: Mouse
Expression System: HEK293 Cells
Cpn10/HSPE1 Protein, Human, Recombinant (His)
Cat.No: TMPY-04804
Species: Human
Expression System: E. coli
HSP18.1 Protein, Pisum sativum, Recombinant (His & SUMO)
Cat.No: TMPH-03133
Species: Pisum sativum
Expression System: E. coli
DegP Protein, E. coli, Recombinant (His)
Cat.No: TMPH-00708
Species: E. coli
Expression System: P. pastoris (Yeast)
HSP40 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00915
Species: Human
Expression System: E. coli
HtpG Protein, Bacteroides fragilis, Recombinant (His & Myc & SUMO)
Cat.No: TMPH-00189
Species: Bacteroides fragilis
Expression System: E. coli
Cornulin Protein, Human, Recombinant (His)
Cat.No: TMPJ-01372
Species: Human
Expression System: E. coli
HSPA5 Protein, Mouse, Recombinant (E. coli, His)
Cat.No: TMPH-02638
Species: Mouse
Expression System: E. coli
HSPA5 Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02639
Species: Mouse
Expression System: P. pastoris (Yeast)
AHSA1 Protein, Human, Recombinant (GST)
Cat.No: TMPH-00887
Species: Human
Expression System: E. coli
HSPB8 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01382
Species: Human
Expression System: E. coli
HSP90 alpha Protein, Mouse, Recombinant (His)
Cat.No: TMPY-06846
Species: Mouse
Expression System: Baculovirus Insect Cells
CRYAB Protein, Human, Recombinant (His)
Cat.No: TMPJ-00755
Species: Human
Expression System: E. coli
HSP60 Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-01876
Species: Human
Expression System: E. coli
HSP70 Protein, Human, Recombinant (His)
Cat.No: TMPY-02443
Species: Human
Expression System: Baculovirus Insect Cells
RpoH Protein, E. coli, Recombinant (His & Myc)
Cat.No: TMPH-00729
Species: E. coli
Expression System: E. coli
TRAP1 Protein, Human, Recombinant (GST)
Cat.No: TMPH-01428
Species: Human
Expression System: E. coli
HSP90 alpha Protein, Human, Recombinant (His)
Cat.No: TMPY-06845
Species: Human
Expression System: Baculovirus Insect Cells
HSC70 Protein, Human, Recombinant (His)
Cat.No: TMPY-02217
Species: Human
Expression System: E. coli
Serpin H1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00995
Species: Human
Expression System: HEK293 Cells
EEF1D Protein, Human, Recombinant (His)
Cat.No: TMPH-01285
Species: Human
Expression System: E. coli
HSP27/HSPB1 Protein, Human, Recombinant (His)
Cat.No: TMPK-00693
Species: Human
Expression System: E. coli
Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi)
Cat.No: TMPK-00015
Species: Human,Mouse,Goat
Expression System: E. coli
Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-00016
Species: Human,Mouse,Goat
Expression System: E. coli
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Cat. No. Product Name Target Signaling Pathways
T70960 Maprotiline-d3 hydrochloride

Maprotiline-d3 is intended for use as an internal standard for the quantification of maprotiline by GC- or LC-MS. Maprotiline is a tricyclic antidepressant. It binds to the norepinephrine transporter (NET) and is selective for NET over the serotonin and dopamine transporters. Maprotiline also binds to the serotonin (5-HT) receptor subtype 5-HT2A, as well as histamine H1, muscarinic acetylcholine, α1-adrenergic, and dopamine D2 receptors. In vivo, maprotiline inhibits norepinephrine reuptake in r...

同位素标记化合物

Maprotiline-d3 hydrochloride
Cat.No: T70960
Synonym:
Target:
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