TRC051384 HCl is an inducer of heat shock protein Hsp70, activating heat shock factor-1 and enhancing Hsp72 expression in neurons and glial cells.

TRC051384，一种属于取代2-丙烯-1-酮类的新化合物，是一种强效的热休克蛋白70（HSP70）诱导剂。使用TRC051384显著减少了短暂性缺血性中风大鼠模型中与中风相关的神经损伤（梗死募集到梗塞区域的面积减少87%，脑水肿减少25%）和残疾，并且即使在缺血发作后8小时内给药，也能有效降低障碍。在缺血发作后4小时内开始治疗的TRC051384，在第2天和第7天的生存率显著提高（分别提高50%和67.3%）。TRC051384诱导HSP70的机制涉及HSF1的激活，并导致伴侣和抗炎活性的提高。这些结果表明，TRC051384具有作为治疗缺血性中风的新型药理学试剂的潜力。

Focal cerebral ischemia was produced in rats by occluding the MCA using the intra luminal suture technique.?Rats subjected to 2 hours focal cerebral ischemia were administered by intra-peritoneal route, TRC051384 or vehicle every 2 hours for 48 hours, from 4th hour or 8th hour after onset of ischemia.?Progression of infarct and edema was assessed up to 48 hours post ischemic insult using magnetic resonance imaging and the neurological disability and survival studied till 7 days.