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Search Results for " rodent "

Targets Recommended: Potassium Channel

81

抑制剂 & 化合物

3

天然产物

8

重组蛋白

3

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T7512	BMS-191011 BMS-A	Potassium Channel	Membrane transporter/Ion channel
	BMS-191011 (BMS-A) 是一种大电导 Ca2+激活的钾通道 (Ca2+-activated potassium (maxi-K) channel) 激活剂，在中风模型中有研究价值。
T9532	MRT-81	Others; Hedgehog/Smoothened	GPCR/G Protein; Others; Stem Cells
	MRT-81 是一种人和啮齿动物 smoothened 受体的有效拮抗剂，能够抑制 hedgehog 的活性，在 Shh-light2 细胞中的IC50值为 41 nM。它可用于研究癌症。
T9786	Lu AF27139	P2X Receptor	Membrane transporter/Ion channel; Neuroscience
	Lu AF27139 是一种有效的选择性 P2X7 受体拮抗剂（人和大鼠的 IC50 分别为 12 和 2.4 nM，小鼠、人和大鼠的 Ki 分别为 22、54 和 13 nM）。 Lu AF27139 可用于中枢神经系统疾病研究。
T25824	ML400 ML 400,CID-73050863,ML-400,CID73050863,CID 73050863	Phosphatase	Metabolism
	ML400 (CID73050863) 是 LMPTP 的变构抑制剂，EC50 为 1μM。 ML400 显示出良好的细胞活性和啮齿动物药代动力学。
T39762	AHR antagonist 5 free base	Aryl Hydrocarbon Receptor	Immunology/Inflammation
	AHR antagonist 5 free base 是一种具有口服活性的 AHR 拮抗剂，在人和啮齿动物细胞系中的 IC50 约为 35-150 nM。
T21818	Pregnenolone Carbonitrile Pregnenolone 16α-carbonitrile ,5-Pregnen-3β-ol-20-one-16α-carbonitrile	P450	Metabolism
	Pregnenolone Carbonitrile (5-Pregnen-3β-ol-20-one-16α-carbonitrile) 是一种啮齿动物-PXR 的激活剂，可诱导 CYP3A 的表达。
TP1666L	Kisspeptin-10, rat acetate(478507-53-8 free base)	GPR; Kisspeptin	Endocrinology/Hormones; GPCR/G Protein
	Kisspeptin-10, rat acetate(478507-53-8 free base) 是啮齿动物 Kisspeptin 受体 (KISS1, GPR54) 的内源性配体。
T0489	Flutamide SCH 13521,氟他胺	Androgen Receptor	Endocrinology/Hormones
	Flutamide (SCH 13521) 是一种抗雄激素化合物，在啮齿动物和犬科动物中的效力与环丙孕酮大致相同。
T40588	Acifluorfen	Others	Others
	Acifluorfen 是一种除草剂。Acifluorfen 是一种原卟啉原氧化酶抑制剂，可促进原卟啉 IX 的积累，并诱导啮齿动物肝脏发生肿瘤。它会引起敏感植物物种中的色素和脂质强烈的光氧化破坏。
T1860	Imepitoin AWD 131-138,ELB-138,伊匹妥英	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Imepitoin (AWD 131-138) 是一种新型的低亲和力部分苯二氮卓受体激动剂，有抗惊厥和抗焦虑作用。
T22419	S-Methylisothiourea sulfate (S)-Methylisothiourea sulfate,S-甲基异硫脲硫酸盐,S-甲基异硫脲半硫酸盐	NOS; NO Synthase; HSV	Immunology/Inflammation; Microbiology/Virology
	S-Methylisothiourea sulfate ((S)-Methylisothiourea sulfate) 是一种选择性 iNOS 抑制剂，在感染性休克的啮齿动物模型中发挥有益作用。
T8960	MONNA	Chloride channel	Membrane transporter/Ion channel
	MONNA 是 TMEM16A (Anoctamin-1)阻滞剂，IC50为 80 nM。它在氯离子存在或不存在的情况下诱导啮齿动物抵抗动脉的血管舒张。
T24051	Exisulind Sulindac sulfone,CP248	Apoptosis; PKA	Apoptosis; Tyrosine Kinase/Adaptors
	Exisulind (CP248) 通过激活蛋白激酶 G (PKG) 诱导细胞凋亡。 Exisulind 在实体瘤和血液癌细胞系中表现出抗肿瘤活性，并且是结肠癌、前列腺癌、膀胱癌、乳腺癌和肺癌啮齿动物模型中肿瘤生长的抑制剂。
T36851L	Peptide5 acetate	Others	Others
	Peptide5 acetate 可减少脊髓损伤后的动物肿胀、星形胶质细胞增生和神经元细胞死亡。 Peptide5 acetate 显着降低啮齿动物离体模型中的脊髓损伤 (SCI) 程度。
T16977	Talampanel GYKI-53773,LY-300164	Apoptosis; GluR	Apoptosis; Neuroscience
	Talampanel (LY-300164) 是一种口服和选择型 AMPA 受体拮抗剂，具有抗癫痫活性。在啮齿动物的中风模型中，它具有神经保护作用。Talampanel 减弱 caspase-3 依赖性细胞凋亡。
T15260	Evenamide NW-3509	Sodium Channel	Membrane transporter/Ion channel
	Evenamide (NW-3509) 是一种口服有效的电压门控钠通道 (sodium channel, VGSC) 阻滞剂，Ki 为 0.4 µM，在精神分裂症中有研究价值。Evenamide 在精神病，躁狂症，抑郁和攻击性的各种啮齿动物模型中具有显著功效。
T70084	Dersalazine Dersalazine Free Base	IL Receptor; Platelet aggregation	Immunology/Inflammation; Others
	Dersalazine (Dersalazine Free Base) 是血小板活化因子抑制剂，通过下调 IL-17表达，在不同啮齿动物型结肠炎中发挥肠道抗炎活性，对溃疡性结肠炎患者具有潜在疗效。
T4364	Aftin-4 Aftin 4,Aftin4	Beta Amyloid; Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	Aftin-4 是一种 β-淀粉样蛋白42(Aβ42) 的诱导剂。
T25853	NBQX Disodium FG9202 disodium,NBQX 2Na	GluR	Neuroscience
	NBQX Disodium (FG9202 disodium) 是高度选择性，竞争型的 AMPA 受体拮抗剂，具有保护神经系统和抗惊厥活性的作用。NBQX Disodium 是NBQX 的盐类物质。 NBQX 是一种有效并具有选择性的AMPA /红藻氨酸受体拮抗剂，可用于拮抗谷氨酸的兴奋性毒性。在啮齿类动物模型中具有抗惊厥作用。
T14212	AMG-1694	Glucokinase	Metabolism
	AMG-1694 是一种强效的葡萄糖激酶-葡萄糖激酶调节蛋白（GK-GKRP）干扰物，能促进 GK-GKRP 复合物的解离，其 IC50 值为 7 nM，从而间接提高 GK 酶的活性。AMG-1694 可使几种啮齿动物糖尿病模型的血糖水平恢复正常，并降低糖尿病动物而非正常血糖动物的血糖。AMG-1694 能有效逆转 GKRP 对 GK 活性的抑制作用，并促进 GK 转位。
T4436	RO1138452 CAY10441	Others; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Others
	RO1138452 (CAY10441) 是一种选择性和可口服的前列环素受体拮抗剂，pKi 为8.3。它拮抗卡前列环素诱导的人神经母细胞瘤腺苷酸环化酶的激活，以剂量依赖性方式阻断环 AMP 积累，具有镇痛活性。
T67791	BMS-903452	GPR	Endocrinology/Hormones; GPCR/G Protein
	BMS-903452是一种有效的、具有选择性的 GPR119激动剂，EC50为14 nM。BMS-903452可用于治疗急性和慢性啮齿动物糖尿病。GPR119主要在胰腺 b 细胞和胃肠道肠内分泌细胞中表达，对9种不同的细胞色素 P450酶没有显著的抑制作用(IC50 > 40 μM)，不激活 PXR (EC50>50 μM)，并且对肝脏(HEPG2)细胞系没有毒性。
T1880	P7C3	Others	Others
	P7C3 是一种 aminopropyl carbazole 类化合物，具有口服活性，可透过血脑屏障，具有神经保护作用。它可用于神经退行性疾病，如帕金森病的研究。
T31406	Dezaguanine Dezaguanina,NSC 261726,CI-908,CI 908	Others	Others
	Dezaguanine is a novel antipurine antimetabolite with significant activity against transplantable rodent solid tumors, particularly breast adenocarcinoma.
T14356	AVE-8134	PPAR	DNA Damage/DNA Repair; Metabolism
	AVE-8134 is an agonist of PPARα. For human and rodent PPARα receptor, the EC50 values are 100 and 3000 nM, respectively.
T69135	AGN-2979	Others	Others
	AGN-2979 is a tryptophan hydroxylase (TPH) activation inhibitor that shows antidepressant properties in rodent models of depression.
TP1666	Kisspeptin-10, rat
	Kisspeptin-10, rat is an Endogenous ligand for the rodent kisspeptin receptor (KISS1, GPR54).
T28032	MF266-1 MF 266-1,MF-266-1	Others	Others
	MF266-1, a selective E prostanoid receptor 4 antagonist, relieves joint inflammation and pain in rodent models of osteoarthritis and rheumatoid.
T39502	Lipid 5	Others	Others
	Lipid 5 is an amino lipid compound that demonstrates proficient mRNA delivery in rodent and primate models, displaying favorable pharmacokinetics and minimal toxicity.
T12419	PF-04634817 succinate	COX	Immunology/Inflammation; Neuroscience
	PF-0463481 succinate is a potent and orally active dual antagonist of CCR2/CCR5 with comparable human and rodent CCR2 potency with IC50 of 20.8 nM.
T69304	MRL20	Others	Others
	MRL20 is a selective PPARγ modulator (SPPARγM) which displays robust anti-diabetic activity with an improved therapeutic window in comparison to a PPARγ full agonist in a rodent efficacy model.
T12419L	PF-04634817	CCR	Immunology/Inflammation; Microbiology/Virology
	PF-0463481 is safe and well-tolerated and has the potential for the study of diabetic nephropathy. PF-0463481 is an effective and orally active dual CCR2/CCR5 antagonist. It also has comparable human and rodent CCR2 potency (rat IC50=20.8 nM). PF-0463481
T16113	ML753286	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions. ML753286 is an orally active and selective inhibitor of BCRP (IC50: 0.6 μM). It is also stable in plasma across species.
T28894	SZV558 SZV 558,SZV-558	Others	Others
	SZV558 is a potent inhibitor of both human and rodent MAO-B. SZV558 is safe in high doses with no hERG and mutagenic activities and demonstrated neuroprotection in an in vivo chronic model of PD.
T9586	Broparestrol (E)-	Others	Others
	Broparestrol (E)- 具有抗生育活性，是啮齿动物乳腺肿瘤发生的有效抑制剂。
T68955	Musettamycin	Others	Others
	Musettamycin is a potent inducer of erythroid differentiation in hemopoietic cells lines of rodent and human origin. It also has antimicrobial effects similar to the anthracycline class since it inhibits gram-positive bacteria and typically doesn't affect gram-negative bacteria.
T68567	AMG-131 besylate	Others	Others
	AMG-131 besylate is a hypoglycemic agent. It is a potent PPARγ partial agonist that displays robust glucose-lowering activity in rodent models of diabetes while exhibiting a reduced side-effects profile compared to marketed TZDs.
T26862	BMS-902483	Others	Others
	BMS-902483 is a potent α7 partial agonist. BMS-902483 improved cognition in preclinical rodent models. BMS-902483 showed FLIR α7 EC50=9.3nM; α7 Electrophysiology, rat; Area EC50 = 140 nM; Peak, Area (Ymax %) = 40, 54. 5-HT3A IC50 = 480 nm.
T69950	Delgocitinib EtOH	Others	Others
	Delgocitinib, also known as LEO-124249 and JTE052, is a potent and selective JAK inhibitor. JTE-052 reduces skin inflammation and ameliorates chronic dermatitis in rodent models: Comparison with conventional therapeutic agents. JTE-052 regulates contact hypersensitivity by downmodulating T cell activation and differentiation.
T38666	CP-346086 dihydrate	Others	Others
	CP-346086 dihydrate is a potent and orally active inhibitor of microsomal triglyceride transfer protein (MTP), exhibiting an IC50 value of 2.0 nM for both human and rodent MTP. This compound effectively lowers plasma cholesterol and triglyceride levels in vivo.
T39303	CP-346086	Others	Others
	CP-346086 is a highly potent and orally bioavailable inhibitor of microsomal triglyceride transfer protein (MTP), exhibiting an IC50 value of 2.0 nM against both human and rodent MTP. This compound effectively reduces plasma levels of cholesterol and triglycerides when administered in vivo.
TP2340	Hemoregulatory peptide 5b hp 5B,Pglu-glu-asp-cys-lys-OH,Peedck,Glp-glu-asp-cys-lys-OH,SP1 Pentapeptide
	Hemoregulatory peptide 5b is a synthetic analog of granulocyte chalone which initially identified in extracts of rodent bone marrow and human leukocytes. Monomer inhibits both formations of GM-CFC colonies and cytotoxic drug-induced recruitment of murine
T36178	Aspalatone	Others	Others
	Aspalatone is an anti-platelet aggregator (IC50 = 180 μM, in vitro) that prolongs bleeding time significantly in a rodent model of thromboembolism. Additionally at a minimal effective dose of 24 mg/kg, aspalatone generates antioxidant and neuroprotective effects against kainic acid-induced epilepsy in rat hippocampus.
T78019	Nangibotide TFA LR12 TFA
	Nangibotide TFA为TREM-1受体抑制剂，调控先天免疫反应。该化合物能降低啮齿动物心肌缺血再灌注模型的系统性及局部炎症。
T21886	HE-3235	Others	Others
	Apoptone 是 3β- 雄烷二醇合成类似物，是一种具有口服生物可利用度的抗癌剂。Apoptone 在前列腺癌和乳腺癌的啮齿类动物模型中具有活性。
T60537	ARUK3001185	Others	Others
	ARUK3001185 (Compound 8l) 是选择性的、口服有效的、脑渗透性的 Notum 抑制剂（IC50 = 6.7 nM），适合在啮齿动物疾病模型中口服给药。
T71093	SB-1578 citrate	Others	Others
	SB-1578 citrate is a novel, orally bioavailable JAK2 inhibitor with specificity for JAK2 within the JAK family and also potent activity against FLT3 and c-Fms. SB1578 blocks the activation of these kinases and their downstream signaling in pertinent cells, leading to inhibition of pathological cellular responses. The biochemical and cellular activities of SB1578 translate into its high efficacy in two rodent models of arthritis.
T14205	AM679	Others	Others
	AM679 is a potent and selective FLAP inhibitor with IC50s of 2.2 nM/0.6 nM/154 nM for FLAP binding/hLA/hWB respectively. IC50 value: 2.2 nM/0.6 nM/154 nM(FLAP binding/hLA/hWB) [1] AM679 showed an improved CYP inhibition profile (IC50 3A4 = 16.7 lM, 2C9 =
T81707	Nangibotide LR12
	Nangibotide为TREM-1受体抑制剂，具有调节先天免疫反应的作用。在啮齿动物心肌缺血再灌注模型中，Nangibotide能有效减轻全身及原位的炎症反应。
T39587	APJ receptor agonist 4	Others	Others
	APJ Receptor Agonist 4 is a potent, orally active apelin receptor (APJ) agonist, demonstrating an EC50 of 0.06 nM and a Ki of 0.07 nM. It exhibits excellent pharmacokinetic profiles in rodent heart failure (HF) models and has shown an acceptable safety profile in preclinical toxicology studies. This compound effectively improves cardiac function, making it valuable for research into HF disease.

化合物

Cat.No: T7512

Synonym: BMS-A

Target: Potassium Channel

Cat.No: T9532

Target: Others, Hedgehog/Smoothened

Cat.No: T9786

Target: P2X Receptor

Cat.No: T25824

Synonym: ML 400,CID-73050863,ML-400,CID73050863,CID 73050863

Target: Phosphatase

AHR antagonist 5 free base

Cat.No: T39762

Target: Aryl Hydrocarbon Receptor

Pregnenolone Carbonitrile

Cat.No: T21818

Synonym: Pregnenolone 16α-carbonitrile ,5-Pregnen-3β-ol-20-one-16α-carbonitrile

Target: P450

Kisspeptin-10, rat acetate(478507-53-8 free base)

Cat.No: TP1666L

Target: GPR, Kisspeptin

Cat.No: T0489

Synonym: SCH 13521,氟他胺

Target: Androgen Receptor

Cat.No: T40588

Target: Others

Cat.No: T1860

Synonym: AWD 131-138,ELB-138,伊匹妥英

Target: GABA Receptor

S-Methylisothiourea sulfate

Cat.No: T22419

Synonym: (S)-Methylisothiourea sulfate,S-甲基异硫脲硫酸盐,S-甲基异硫脲半硫酸盐

Target: NOS, NO Synthase, HSV

Cat.No: T8960

Target: Chloride channel

Cat.No: T24051

Synonym: Sulindac sulfone,CP248

Target: Apoptosis, PKA

Peptide5 acetate

Cat.No: T36851L

Target: Others

Cat.No: T16977

Synonym: GYKI-53773,LY-300164

Target: Apoptosis, GluR

Cat.No: T15260

Synonym: NW-3509

Target: Sodium Channel

Cat.No: T70084

Synonym: Dersalazine Free Base

Target: IL Receptor, Platelet aggregation

Cat.No: T4364

Synonym: Aftin 4,Aftin4

Target: Beta Amyloid, Gamma-secretase

Cat.No: T25853

Synonym: FG9202 disodium,NBQX 2Na

Target: GluR

Cat.No: T14212

Target: Glucokinase

Cat.No: T4436

Synonym: CAY10441

Target: Others, Prostaglandin Receptor

Cat.No: T67791

Target: GPR

Cat.No: T1880

Target: Others

Cat.No: T31406

Synonym: Dezaguanina,NSC 261726,CI-908,CI 908

Target: Others

Cat.No: T14356

Target: PPAR

Cat.No: T69135

Target: Others

Kisspeptin-10, rat

Cat.No: TP1666

Cat.No: T28032

Synonym: MF 266-1,MF-266-1

Target: Others

Cat.No: T39502

Target: Others

PF-04634817 succinate

Cat.No: T12419

Target: COX

Cat.No: T69304

Target: Others

Cat.No: T12419L

Target: CCR

Cat.No: T16113

Target: AMPK

Cat.No: T28894

Synonym: SZV 558,SZV-558

Target: Others

Broparestrol (E)-

Cat.No: T9586

Target: Others

Cat.No: T68955

Target: Others

AMG-131 besylate

Cat.No: T68567

Target: Others

Cat.No: T26862

Target: Others

Delgocitinib EtOH

Cat.No: T69950

Target: Others

CP-346086 dihydrate

Cat.No: T38666

Target: Others

Cat.No: T39303

Target: Others

Hemoregulatory peptide 5b

Cat.No: TP2340

Synonym: hp 5B,Pglu-glu-asp-cys-lys-OH,Peedck,Glp-glu-asp-cys-lys-OH,SP1 Pentapeptide

Cat.No: T36178

Target: Others

Nangibotide TFA

Cat.No: T78019

Synonym: LR12 TFA

Cat.No: T21886

Target: Others

Cat.No: T60537

Target: Others

SB-1578 citrate

Cat.No: T71093

Target: Others

Cat.No: T14205

Target: Others

Cat.No: T81707

Synonym: LR12

APJ receptor agonist 4

Cat.No: T39587

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T2925	Schisandrin B gamma-Schisandrin,Schizandrin B,五味子素B,五味子乙素,Schisandrin B (Sch B),Wuweizisu-B	ATM/ATR; Reactive Oxygen Species; Autophagy	Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; NF-κB; PI3K/Akt/mTOR signaling
	Schisandrin B (Schisandrin B (Sch B)) 是从五味子中分离联苯环辛二烯衍生物，对啮齿类动物的肝脏和心脏的抗氧化作用。
T5S0661	Koumine	Others	Others
	Koumine 是一种从钩吻中得到的生物碱，具有高效抗肿瘤活性，在肿瘤细胞中能够提高 Bax/Bcl-2 的蛋白比例和 caspase-3 的表达。在类风湿性关节炎动物模型中，它能够预防关节炎的发展。它具有抗焦虑、抗应激、抗银屑病作用，也可用于缓解疼痛的研究。
T4S0969	Obtusifolin 决明蒽醌,决明蒽醌；美决明子素	Antioxidant; NF-κB	NF-κB; oxidation-reduction
	Obtusifolin 是分离自决明子的种子中，能够抑制NF-kB 通路，调节气道上皮细胞中 MUC5AC 粘蛋白的基因表达和产生。它通过靶向甲状旁腺激素相关蛋白来抑制邻苯二甲酸酯诱导的乳腺癌骨转移。

天然产物

Cat.No: T2925

Synonym: gamma-Schisandrin,Schizandrin B,五味子素B,五味子乙素,Schisandrin B (Sch B),Wuweizisu-B

Target: ATM/ATR, Reactive Oxygen Species, Autophagy

Cat.No: T5S0661

Target: Others

Cat.No: T4S0969

Synonym: 决明蒽醌,决明蒽醌；美决明子素

Target: Antioxidant, NF-κB

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03604	VAMP3 Protein, Human, Recombinant (His) vesicle-associated membrane protein 3,CEB	Human	E. coli
	VAMP3, also known as cellubrevin, is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. Because of VAMP3 gene's high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, VAMP3 was shown to be the human equivalent ...
TMPY-02288	Glyoxalase II/HAGH Protein, Human, Recombinant (His) HAGH1,GLO2,GLX2,hydroxyacylglutathione hydrolase,GLXII	Human	E. coli
	HAGH (Hydroxyacylglutathione Hydrolase) is a Protein Coding gene. 3 alternative splicing and alternative initiation of human isoforms have been reported. The enzyme encoded by this gene is classified as a thioesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. HAGH belongs to the Metallo-beta-lactamase superfamily. HAGH is widely expressed in the kidney, liver, and other tissues. Diseases associated with HAGH include Hydroxyacyl Glutathio...
TMPY-02891	PSG6 Protein, Human, Recombinant (His) PSG12,PSG6,PSBG-6,pregnancy specific β-1-glycoprotein 6,PSG1...	Human	Baculovirus Insect Cells
	PSG6 is a pregnancy-specific glycoprotein(PSG). PSGs are secreted proteins produced by the rodent and primate placenta and play a critical role in pregnancy success. The levels of PSGs are highest during the third trimester of pregnancy, a time marked by the most profound suppression of MS disease attacks. PSGs regulate T-cell function. The regulation of T-cell function during pregnancy is likely the result of significant hormonal changes and may well involve immunoregulatory proteins derived fr...
TMPY-03627	CREB3L1 Protein, Human, Recombinant (aa 396-519, His) OASIS,PSEC0238,cAMP responsive element binding protein 3-lik...	Human	HEK293 Cells
	CREB3L1, also known as OASIS, is a cellular transcription factor synthesized as a membrane-bound precursor. It is a putative endoplasmic reticulum (ER) stress sensor in astrocytes with a mechanism of activation. OASIS mRNA expression was detected in pancreatic β-cell lines and rodent islets, and the expression level was up-regulated by ER stress-inducing compounds. CREB3L1 may have a role in pancreas development. CREB3L1 may also play an important role in limiting virus spread by inhibiting prol...
TMPJ-00906	CRHBP Protein, Human, Recombinant (His) CRF-BP,CRF-Binding Protein,Corticotropin-Releasing Factor-Bi...	Human	HEK293 Cells
	Corticotropin-Releasing Factor-Binding Protein (CRHBP) is a 37 kDa secreted glycoprotein that binds both CRH and urocortin in a 42 kDa extracellular complex. The molecule is approximately 300 amino acids in length and demonstrates five intrachain disulfide bonds. Difference between CRHBP from different species exist, human CRHBP is found in plasma while rodent and sheep CRHBP is limited to neuroendocrine tissues. CRHBP may inactivate CRH and may prevent inappropriate pituitary-adrenal stimulatio...
TMPJ-01187	Siglec-E Protein, Mouse, Recombinant (hFc) SiglecE,Siglec-E	Mouse	HEK293 Cells
	Siglecs are sialic acid specific I‑type lectins that are characterized by an extracellular domain (ECD) with an N‑terminal Ig‑like V‑set domain followed by varying numbers of Ig‑like C2‑set domains. Mouse Siglec‑E, also known as Myeloid Inhibitory Siglec (MIS), is an 80 ‑ 85 kDa member of the CD33‑related subfamily of Siglecs. Rodent and primate Siglec gene families have significantly diverged, and Siglec‑9 is the most likely human ortholog of mouse Siglec‑E. Siglec‑E is expressed as a heavily N...
TMPY-02766	PSPH Protein, Human, Recombinant PSP,phosphoserine phosphatase,PSPHD	Human	E. coli
	Phosphoserine phosphatase (PSPH) belongs to a subfamily of the phosphotransferases. PSPH is the rate-limiting enzyme in l-serine biosynthesis. It has previously been found that Phosphoserine phosphatase (PSPH) plays a role in epidermal homeostasis. Phosphoserine phosphatase (PSP) catalyzes the hydrolysis of phosphoserine to serine. Phosphoserine phosphatase (PSPH) expression has been examined in human-mouse somatic cell hybrids retaining different combination of human chromosomes. Phosphoserine ...
TMPJ-00100	Artemin Protein, Human, Recombinant ARTN,Artemin,EVN,Enovin,Neublastin	Human	E. coli
	Human Artemin is a GDNF family ligand that is distantly related to the TGF-β superfamily of molecules. It is synthesized as a preproprotein, and contains a variable length pre-, or signal sequence, plus a 68 amino acid (aa) proregion and a 113 aa mature segment. Following synthesis and proteolytic processing, mature ARTN is secreted as a presumably glycosylated, 28 kDa disulfide-linked homodimer that contains three intrachain disulfide bonds and the typical TGF-β signature cysteine-knot motif. I...

重组蛋白

VAMP3 Protein, Human, Recombinant (His)

Cat.No: TMPY-03604

Species: Human

Expression System: E. coli

Glyoxalase II/HAGH Protein, Human, Recombinant (His)

Cat.No: TMPY-02288

Species: Human

Expression System: E. coli

PSG6 Protein, Human, Recombinant (His)

Cat.No: TMPY-02891

Species: Human

Expression System: Baculovirus Insect Cells

CREB3L1 Protein, Human, Recombinant (aa 396-519, His)

Cat.No: TMPY-03627

Species: Human

Expression System: HEK293 Cells

CRHBP Protein, Human, Recombinant (His)

Cat.No: TMPJ-00906

Species: Human

Expression System: HEK293 Cells

Siglec-E Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-01187

Species: Mouse

Expression System: HEK293 Cells

PSPH Protein, Human, Recombinant

Cat.No: TMPY-02766

Species: Human

Expression System: E. coli

Artemin Protein, Human, Recombinant

Cat.No: TMPJ-00100

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T71206	Tiagabine-d6 hydrochloride
	Tiagabine-d6 is intended for use as an internal standard for the quantification of tiagabine by GC- or LC-MS. Tiagabine is an inhibitor of GABA transporter 1. It inhibits seizures induced by DMCM in mice. Tiagabine reduces allodynia in a rodent model of neuropathic pain when used at a dose of 72.8 µmol/kg, and it acts synergistically with gabapentin to delay pain responses in mice in the hot plate test. Formulations containing tiagabine have been used as adjunctive therapies in the treatment of ...
TMIJ-0240	Lacosamide-d3 (Acetyl-d3)
	Lacosamide-d3 (Acetyl-d3) 是 Lacosamide 的氘代化合物。Lacosamide 的 CAS 号为 175481-36-4。Lacosamide是一种功能化氨基酸。Lacosamide以一种新的方式调节钠通道：它选择性地增强钠通道缓慢失活，而对快速失活没有影响Lacosamine在不同的啮齿类动物癫痫发作模型中显示出抗癫痫作用，在反映神经性疼痛和慢性炎性疼痛的不同类型和症状的实验动物模型中显示了抗伤害潜力。
TMID-0247	LacosaMide-d3
	LacosaMide-d3 是 LacosaMide 的氘代化合物。LacosaMide 的 CAS 号为 175481-36-4。Lacosamide是一种功能化氨基酸。Lacosamide以一种新的方式调节钠通道：它选择性地增强钠通道缓慢失活，而对快速失活没有影响Lacosamine在不同的啮齿类动物癫痫发作模型中显示出抗癫痫作用，在反映神经性疼痛和慢性炎性疼痛的不同类型和症状的实验动物模型中显示了抗伤害潜力。

同位素标记化合物

Tiagabine-d6 hydrochloride

Cat.No: T71206

Lacosamide-d3 (Acetyl-d3)

Cat.No: TMIJ-0240

Cat.No: TMID-0247

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