|
TMPY-01253
|
LAMP1 Protein, Human, Recombinant (His)
CD107a,lysosomal-associated membrane protein 1,LGP1...
|
Human
|
HEK293 Cells
|
|
LAMP1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.8 kDa and the accession number is A0A024RDY3. |
|
TMPY-03685
|
LAMP2 Protein, Cynomolgus, Recombinant (His)
lysosomal-associated membrane protein 2
|
Cynomolgus
|
HEK293 Cells
|
|
LAMP2 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.4 kDa and the accession number is G7Q3L7. |
|
TMPY-02916
|
LAMP1 Protein, Rat, Recombinant (hFc)
lysosomal-associated membrane protein 1
|
Rat
|
HEK293 Cells
|
|
LAMP1 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65.1 kDa and the accession number is P14562. |
|
TMPH-02771
|
GBA Protein, Mouse, Recombinant (His & SUMO)
Lysosomal galactosylceramidase,Cholesteryl-beta-glu...
|
Mouse
|
E. coli
|
|
GBA Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli. |
|
TMPH-02772
|
GBA Protein, Mouse, Recombinant (His)
Cholesteryl-beta-glucosidase,Lysosomal galactosylce...
|
Mouse
|
P. pastoris (Yeast)
|
|
GBA Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 57.5 kDa and the accession number is P17439. |
|
TMPJ-00964
|
PRCP Protein, Human, Recombinant (His)
PCP,Proline Carboxypeptidase,PRCP,Lysosomal Pro-X C...
|
Human
|
HEK293 Cells
|
|
Lysosomal Pro-X Carboxypeptidase (PRCP) belongs to the peptidase S28 family. PRCP is detected in many tissues, with highest levels observed in placenta, lung, and liver. It is also present in the heart, brain, pancreas, and kidney. PRCP exists as a homodimer. PRCP cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH. PRCP has been s... |
|
TMPH-01624
|
GBA Protein, Human, Recombinant
Lysosomal glycosylceramidase,Acid beta-glucosidase,...
|
Human
|
E. coli
|
|
Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction tha... |
|
TMPH-01623
|
GBA Protein, Human, Recombinant (His & Myc & SUMO)
Lysosomal acid glucosylceramidase,GBA1,Lysosoma...
|
Human
|
E. coli
|
|
Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction tha... |
|
TMPH-03342
|
GBA2 Protein, Rat, Recombinant (His)
Bile acid glucosyl transferase GBA2,Glucosylceramidase 2,Non...
|
Rat
|
E. coli
|
|
GBA2 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 42.6 kDa and the accession number is Q5M868. |
|
TMPY-03643
|
LAMP3/CD208 Protein, Rhesus, Recombinant (His)
lysosomal associated membrane protein 3,LAMP3
|
Rhesus
|
HEK293 Cells
|
|
LAMP3/CD208 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.6 kDa and the accession number is Q8MJJ2. |
|
TMPH-00497
|
PLA2G15 Protein, Canine, Recombinant (His & Myc)
Lysophospholipase 3,Lysosomal phospholipase A2,...
|
Canine
|
Baculovirus Insect Cells
|
|
PLA2G15 Protein, Canine, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 46.8 kDa and the accession number is Q6XPZ3. |
|
TMPH-02692
|
PLA2G15 Protein, Mouse, Recombinant (His & Myc)
Phospholipase A2 group XV,1-O-acylceramide synthase,Pla2g15,...
|
Mouse
|
E. coli
|
|
PLA2G15 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 50.5 kDa and the accession number is Q8VEB4. |
|
TMPY-00963
|
ASAH2 Protein, Mouse, Recombinant (His)
N-acylsphingosine amidohydrolase (non-lysosomal cer...
|
Mouse
|
HEK293 Cells
|
|
ASAH2 (N-acylsphingosine amidohydrolase 2), also known as neutral ceramidase, is a type II integral membrane protein that can be cleaved to produce a soluble secreted protein. The enzyme is abundant in the brush border membranes of the intestine, and also expressed in several tissues such as kidney, brain and liver. The primary structure of ASAH2/neutral ceramidase is highly conserved from bacteria to humans, however, there is a clear difference in the molecular architecture. The murine ASAH2 po... |
|
TMPY-04115
|
LAMP2 Protein, Human, Recombinant (His)
lysosomal-associated membrane protein 2,LAMP-2,CD10...
|
Human
|
HEK293 Cells
|
|
LAMP2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.77 kDa and the accession number is P13473-2. |
|
TMPY-04137
|
ATP6V1F Protein, Human, Recombinant (GST)
Vma7,ATPase, H+ transporting, lysosomal 14kDa, V1 s...
|
Human
|
E. coli
|
|
ATP6V1F encodes a component of vacuolar ATPase mediating acidification. The cDNA and the genomic sequences of ATP6V1F were cloned successfully for the first time from the Giant Panda (Ailuropoda melanoleuca) using reverse transcription polymerase chain reaction and touchdown-polymerase chain reaction, respectively. Topology prediction showed that there is one protein kinase C phosphorylation site, two Casein kinase II phosphorylation sites, and one N-myristoylation site in the ATP6V1F protein. U... |
|
TMPH-02906
|
Sialidase-1 Protein, Mouse, Recombinant (His)
G9 sialidase,N-acetyl-alpha-neuraminidase 1,Sialidase-1,Neu1...
|
Mouse
|
E. coli
|
|
Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage. Sialidase-1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 46.3 kDa and the accession number is O35657. |
|
TMPY-02980
|
BLOC1S2 Protein, Human, Recombinant (GST)
CEAP,CEAP11,BLOS2,biogenesis of lysosomal organelle...
|
Human
|
E. coli
|
|
BLOC1S2, also known as BLOS2, belongs to the BLOC1S2 family. It is a component of BLOC-1 complex. The BLOC-1 complex is composed of BLOC1S1, BLOC1S2, BLOC1S3, DTNBP1, MUTED, PLDN, CNO/cappuccino and SNAPIN. The BLOC-1 complex is required for normal biogenesis of lysosome-related organelles, such as platelet dense granules and melanosomes. BLOC1S2 interacts directly with BLOC1S1, BLOC1S3, MUTED, CNO/cappuccino and SNAPIN. It may play a role in cell proliferation. It also plays a role in intracell... |
|
TMPJ-00837
|
LAMP1 Protein, Mouse, Recombinant (His)
Lysosomal membrane glycoprotein A,CD107a,LAMP-1,CD1...
|
Mouse
|
HEK293 Cells
|
|
Lysosomal associated membrane protein 1 (LAMP1) is an approximately 120 kDa transmembrane glycoprotein that is a major protein component of lysosomal membranes. Mature mouse LAMP1 consists of a 346 amino acid (aa) intralumenal domain (ECD), a 24 aa transmembrane segment, and a 12 aa cytoplasmic tail. Its lumenal domain is organized into two heavily N-glycosylated regions separated by a Ser/Pro-rich linker that carries a minor amount of O-linked glycosylation. Within the lumenal domain, mouse LAM... |
|
TMPH-03323
|
LIPA Protein, Rat, Recombinant (His)
Lysosomal acid lipase/cholesteryl ester hydrolase,L...
|
Rat
|
E. coli
|
|
Catalyzes the deacylation of triacylglyceryl and cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol. LIPA Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 48.6 kDa and the accession number is Q64194. |
|
TMPH-01626
|
LIPA Protein, Human, Recombinant (GST)
Lysosomal acid lipase/cholesteryl ester hydrolase,L...
|
Human
|
E. coli
|
|
Catalyzes the deacylation of triacylglyceryl and cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol. LIPA Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 70.0 kDa and the accession number is P38571. |
|
TMPH-01625
|
LIPA Protein, Human, Recombinant (His)
Cholesteryl esterase,Lysosomal acid lipase/choleste...
|
Human
|
P. pastoris (Yeast)
|
|
Catalyzes the deacylation of triacylglyceryl and cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol. LIPA Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 45.0 kDa and the accession number is P38571. |
|
TMPY-01013
|
LAMP3/CD208 Protein, Human, Recombinant (His)
LAMP,DC LAMP,lysosomal associated membrane protein ...
|
Human
|
HEK293 Cells
|
|
LAMP3/CD208 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39 kDa and the accession number is Q9UQV4. |
|
TMPY-02382
|
LAMP2 Protein, Mouse, Recombinant (His)
Mac3,LGP-B,CD107b,LampII,Lamp-2a,lysosomal-associat...
|
Mouse
|
HEK293 Cells
|
|
LAMP2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40.6 kDa and the accession number is P17047-1. |
|
TMPY-02252
|
LAMTOR2 Protein, Human, Recombinant (His)
Ragulator2,p14,MAPBPIP,MAPKSP1AP,RP11-336K24.9,HSPC003,late ...
|
Human
|
E. coli
|
|
Ragulator complex protein LAMTOR2, also known as Endosomal adaptor protein p14, Late endosomal/lysosomal Mp1-interacting protein, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2, Mitogen-activated protein-binding protein-interacting protein, Roadblock domain-containing protein 3, LAMTOR2, MAPBPIP, and ROBLD3, is a protein which belongs to the GAMAD family. LAMTOR2 / ROBLD3 is a regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factor... |
|
TMPH-02023
|
Renin receptor Protein, Human, Recombinant (His)
Vacuolar ATP synthase membrane sector-associated protein M8-...
|
Human
|
E. coli
|
|
Renin receptor Protein, Human, Recombinant (His) is expressed in E. coli. |
|
TMPJ-01287
|
Sialidase-1 Protein, Human, Recombinant (His)
NEU1,NANH,Lysosomal Sialidase,G9 Sialidase,Sialidas...
|
Human
|
HEK293 Cells
|
|
Sialidase-1 belongs to the N-acetyl-a neuraminidase family. Sialidase-1 is expressed in many tissues; it is highly expressed in the pancreas, and weakly expressed in the brain. Sialidase-1 is a lysosomal enzyme, which cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. Deficiencies in the human enzyme Sialidase-1 leads to sialidosis, a rare lysosomal storage disease. Sialidase-1 has been shown to interact with Cathepsin A (protective protein), β-galactosi... |
|
TMPH-01771
|
ASAH2 Protein, Human, Recombinant (His)
HNAC1,LCDase (hCD),BCDase,Non-lysosomal ceramidase,...
|
Human
|
E. coli
|
|
ASAH2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 25.2 kDa and the accession number is Q9NR71. |
|
TMPH-03324
|
LIMPII/SR-B2 Protein, Rat, Recombinant (His & Myc)
85 kDa lysosomal membrane sialoglycoprotein,Scarb2,...
|
Rat
|
E. coli
|
|
Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting. LIMPII/SR-B2 Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 53.7 kDa and the accession number is P27615. |
|
TMPJ-00299
|
LIMPII/SR-B2 Protein, Mouse, Recombinant (hFc)
LIMP II,Lysosome membrane protein II,SCARB2,85 kDa lysos...
|
Mouse
|
HEK293 Cells
|
|
Lysosome membrane protein II (LIMPII)，also known as SCARB2, is a type III multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all tissues and cell types so far examined. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junc... |
|
TMPH-01985
|
ASAH2B Protein, Human, Recombinant (His)
ASAH2L,ASAH2B,Putative inactive non-lysosomal ceram...
|
Human
|
E. coli
|
|
N/A. ASAH2B Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.0 kDa and the accession number is P0C7U1. |
|
TMPJ-00298
|
CD36 Protein, Human, Recombinant (aa 27-432, His)
LGP85,Scavenger Receptor Class B Member 2,CD36,Lysosome Memb...
|
Human
|
HEK293 Cells
|
|
Scavenger Receptor Class B Member 2 (SCARB2) is a type III multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all tissues and cell types so far examined. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstructio... |
|
TMPH-01996
|
LAMTOR1 Protein, Human, Recombinant (His)
LAMTOR1,Late endosomal/lysosomal adaptor and MAPK a...
|
Human
|
E. coli
|
|
LAMTOR1 Protein, Human, Recombinant (His) is expressed in E. coli. |
|
TMPJ-01378
|
Mp1 Protein, Human, Recombinant (His)
Mitogen-Activated Protein Kinase Kinase 1-Interacting Protei...
|
Human
|
E. coli
|
|
Mitogen-Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) was identified as an interacting protein that belongs to the LAMTOR3 family. MAPKSP1 restricted to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. MAPKSP1 interacts with MAP2K1/MEK1 and MAPK2 and enhances the activation of MAPK2, and thus is thought to function as an adaptor to enhance the eff... |
|
TMPH-01029
|
CAPN1 Protein, Human, Recombinant (His)
CANPL1,CAPN1,Calpain-1 catalytic subunit,Micromolar-calpain,...
|
Human
|
E. coli
|
|
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409'. CAPN1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 85.9 kDa and the accession number is P07384. |
|
TMPH-01031
|
CAPN2 Protein, Human, Recombinant (His)
Calpain-2 catalytic subunit,Millimolar-calpain,Calpain-2 lar...
|
Human
|
E. coli
|
|
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs. CAPN2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 82... |
|
TMPY-00828
|
Iduronate 2 sulfatase/IDS Protein, Human, Recombinant (His)
MPS2,IDS,SIDS,iduronate 2-sulfatase
|
Human
|
HEK293 Cells
|
|
Iduronate 2-Sulfatase, also known as IDS, is a member of the highly conserved sulfatase family of enzymes that catalyze the hydrolysis of O- and N-sulfate esters from a variety of substrates. The human Iduronate 2-Sulfatase/IDS consists of a signal peptide, a propeptide, and a mature chain that may be further processed into two chains. Among the identified 18 human sulfatases, Iduronate 2-Sulfatase/IDS is required for the lysosomal degradation of the glycosaminoglycans (GAG), heparan sulfate, an... |
|
TMPY-02585
|
Acid sphingomyelinase/SMPD1 Protein, Mouse, Recombinant (His)
aSMase,ASM,Zn-SMase,A-SMase,sphingomyelin phosphodiesterase ...
|
Mouse
|
Baculovirus Insect Cells
|
|
Sphingomyelin phosphodiesterase 1 (SMPD1) , also known as ASM ( acid sphingomyelinase ), is a member of the acid sphingomyelinase family of enzymes. Three isoforms have been identified, isoform 1 is 631 amino acids (aa) in length as the pro form, while Isoform 2 and isoform 3 have lost catalytic activity. The active SMPD1 isoform 1 contains one saposin B-type domain that likely interacts with sphingomyelin, and a catalytic region. Human SMPD1 is 86% aa identical to mouse SMPD1. SMPD1 is a monome... |
|
TMPJ-00869
|
GLB1 Protein, Human, Recombinant (His)
Lactase,Acid Beta-Galactosidase,Elastin Receptor 1,GLB1,Acid...
|
Human
|
HEK293 Cells
|
|
β Galactosidase is a lysosomal β Galactosidase that hydrolyzes the terminal β Galactose from Ganglioside and Keratan sulfate. In lysosome, the mature β Galactosidase protein associates with Cathepsin A and Neuraminidase 1 to form the lysosomal multienzyme complex . An alternative splicing at the RNA level of β Galactosidase results a catalytically inactive β Galactosidase that plays an important role in vascular development. Defects of β-galactosidase (GLB1) are the cause of diseases like GM1-ga... |
|
TMPY-02887
|
IFI30 Protein, Human, Recombinant (His)
interferon γ inducible protein 30,IP30,IFI-30,GILT,IP-30,int...
|
Human
|
HEK293 Cells
|
|
IFI30 belongs to the GILT family. This family includes the two characterized human gamma-interferon-inducible lysosomal thiol reductase (GILT) sequences: P13284 and Q9UL08. It also contains several other eukaryotic putative proteins with similarity to GILT. The aligned region contains three conserved cysteine residues. Besides, the two GILT sequences possess a C-X(2)-C motif that is shared by some of the other sequences in the family. This motif is thought to be associated with disulfide bond re... |
|
TMPK-01001
|
RNF43 Protein, Mouse, Recombinant (hFc)
Rnf43,RING finger protein 43,RING-type E3 ubiquitin transfer...
|
Mouse
|
HEK293 Cells
|
|
RNF43 (E3 ubiquitin-protein ligase RNF43 or RING-type E3 ubiquitin transferase RNF43) functions as a tumor suppressor, by exerting a predominant negative feedback mechanism in the Wnt/β-catenin signaling pathway. RNF43 inhibits Wnt/beta-catenin signaling by ubiquitinating Frizzled receptor and targeting it to the lysosomal pathway for degradation. |
|
TMPH-02432
|
Legumain Protein, Cynomolgus, Recombinant (E. coli, His & Myc)
Legumain,Protease, cysteine 1,LGMN,Asparaginyl endopeptidase
|
Cynomolgus
|
E. coli
|
|
Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Legumain Protein, Cynomolg... |
|
TMPY-03282
|
FUCA1 Protein, Human, Recombinant (His)
fucosidase, alpha-L- 1, tissue,fucosidase, α-L- 1, tissue,FU...
|
Human
|
HEK293 Cells
|
|
FUCA1 is a lysosomal enzyme involved in the degradation of fucose-containing glycoproteins and glycolipids. Mutations in FUCA1 gene are associated with fucosidosis (FUCA1D), which is an autosomal recessive lysosomal storage disease. Different phenotypes include clinical features such as neurologic deterioration, growth retardation, visceromegaly, and seizures in a severe early form; coarse facial features, angiokeratoma corporis diffusum, spasticity and delayed psychomotor development in a longe... |
|
TMPH-02557
|
CAPN1 Protein, Mouse, Recombinant (His)
CANP 1,Calpain-1 catalytic subunit,muCANP,CANPL1,Calcium-act...
|
Mouse
|
E. coli
|
|
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-388' and 'His-410'. |
|
TMPH-01030
|
CAPN14 Protein, Human, Recombinant (His & Myc)
Calpain-14,Calcium-activated neutral proteinase 14,CAPN14,CA...
|
Human
|
Baculovirus Insect Cells
|
|
Calcium-regulated non-lysosomal thiol-protease. CAPN14 Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 78.6 kDa and the accession number is A8MX76. |
|
TMPJ-00863
|
GNS Protein, Human, Recombinant (His)
N-Acetylglucosamine-6-Sulfatase,G6S,GNS,Glucosamine-6-Sulfat...
|
Human
|
HEK293 Cells
|
|
N-Acetylglucosamine-6-Sulfatase is a member of the Sulfatase family. N-Acetylglucosamine-6-Sulfatase is required for the lysosomal degradation of the Glycosaminoglycans (GAG) Heparan Sulfate and Keratan Sulfate. N-Acetylglucosamine-6-Sulfatase hydrolyzes the 6-Sulfate groups of the N-Acetyl-D-Glucosamine 6-Sulfate units of Heparan Sulfate and Keratan Sulfate. N-Acetylglucosamine-6-Sulfatase binds 1 Calcium ion per subunit. N-Acetylglucosamine-6-Sulfatase deficiency are the cause of Mucopolysacch... |
|
TMPY-05099
|
GBA/glucocerebrosidase Protein, Human, Recombinant (His)
glucosidase, β, acid,GLUC,GCB,GBA1,glucosidase, beta, acid
|
Human
|
HEK293 Cells
|
|
Mutations in the GBA gene, encoding the lysosomal hydrolase glucocerebrosidase (GCase), are the most common known genetic risk factor for Parkinson's disease (PD) and dementia with Lewy bodies (DLB). ASAH1 (acid ceramidase 1) and GBA2 (glucocerebrosidase 2) enzymes that mediate glucosylsphingosine production and metabolism are attractive therapeutic targets for treating mutant GBA-associated PD. |
|
TMPH-02431
|
Legumain Protein, Cynomolgus, Recombinant (His & Myc)
Legumain,Protease, cysteine 1,Asparaginyl endopeptidase,LGMN
|
Cynomolgus
|
Baculovirus Insect Cells
|
|
Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Legumain Protein, Cynomolg... |
|
TMPH-02667
|
Galactosylceramidase Protein, Mouse, Recombinant
Galactocerebroside beta-galactosidase,Galactocerebrosidase,G...
|
Mouse
|
E. coli
|
|
Hydrolyzes the galactose ester bonds of glycolipids such as galactosylceramide and galactosylsphingosine. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon. |
|
TMPY-00732
|
Cathepsin C Protein, Human, Recombinant (His)
DPP-I,PLS,JP,cathepsin C,CPPI,DPPI,PDON1,PALS,DPP1,JPD,HMS
|
Human
|
HEK293 Cells
|
|
Cathepsins are proteases found in many types of cells conserved in all animals, which have a vital role in mammalian cellular turnover such as bone resorption. The lysosomal cysteine protease Cathepsin C (CTSC), also known as dipeptidyl peptidase I (DPPI/DPP1), activates a number of granule-associated serine proteases with pro-inflammatory and immune functions by removal of their inhibitory N-terminal dipeptides. This lysosomal exo-cysteine protease belonging to the peptidase C1 family. Active c... |
|
TMPJ-00823
|
UBB Protein, Human, Recombinant
UBB,Polyubiquitin-B
|
Human
|
E. coli
|
|
Polyubiquitin-B(UBB) is one of Ubiquitins. Ubiquitin is one of the most conserved proteins known in eukaryotic organisms. Ubiquitin is required for ATP-dependent, non-lysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. |
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