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Targets Recommended: Others FLAP Epoxide Hydrolase

77

抑制剂 & 化合物

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天然产物

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化合物库

5

重组蛋白

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同位素标记化合物

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Cat. No.	Product Name
L2151	化疗药物库		48 compounds
	48 个肿瘤化疗药物，可以用于高通量和高内涵筛选；

化合物库

化疗药物库

Cat.No: L2151

Compounds: 48

Cat. No.	Product Name	Target	Signaling Pathways
T8844	Diflapolin	Others; FLAP; Epoxide Hydrolase	Immunology/Inflammation; Metabolism; Others
	Diflapolin 是高活性的双 5-脂氧合酶激活蛋白(FLAP)/可溶性环氧化物水解酶抑制剂，具有显著的抗炎作用和较高的靶向选择性。它抑制分离的 sEH 的活性，IC50为20 nM。它还抑制完整人单核细胞和中性粒细胞中 5-LOX 产物的形成，IC50分别为 30 和 170 nM。
T8313	HCH6-1	Others	Others
	HCH6-1 是甲酰肽受体 1 的竞争性二肽拮抗剂。它能够抑制 fMLF (FPR1激动剂) 特异性激活的人中性粒细胞的趋化性、超氧阴离子生成和弹性酶释放。动物实验中，它对急性肺损伤具有保护作用，可用于研究 FPR1 参与的炎症性肺部疾病。
T9043	AS1810722	P450; STAT	JAK/STAT signaling; Metabolism; Stem Cells
	AS1810722 是口服有效的STAT6抑制剂，IC50为 1.9 nM。它是一种稠合双环嘧啶衍生物，对有良好的CYP3A4抑制作用，具有用于过敏性疾病，如哮喘和特应性疾病的研究潜力。
T1115	Doxylamine succinate 琥珀酸多西拉敏,Decapryn	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Doxylamine succinate (Decapryn) 是一种吡啶衍生物组胺 H1 拮抗剂，具有明显的镇静特性。它竞争性阻断组胺 H1 受体并限制典型的过敏和过敏反应，可防止组胺引起的皮肤和粘膜疼痛和瘙痒。
T0946	Mepivacaine hydrochloride Mepivacaine HCl,盐酸甲哌卡因	Sodium Channel	Membrane transporter/Ion channel
	Mepivacaine hydrochloride (Mepivacaine HCl) 是具有局部麻醉特性的酰胺衍生物。Mepivacaine hydrochloride 与神经元细胞膜上特定的电压门控钠离子通道结合，抑制钠离子内流和膜去极化。
T35367	Thioacetamide TAA,硫代乙酰胺	Others	Others
	Thioacetamide 是一种肝毒剂，广泛用于诱导实验性肝损伤，在大鼠中引起肝细胞坏死和随后的炎症（主要是 M1-/M2-巨噬细胞，没有中性粒细胞浸润）。
T2018	Apilimod 阿匹莫德,阿吡莫德,STA 5326	IL Receptor; PI3K; Interleukin	Immunology/Inflammation; PI3K/Akt/mTOR signaling
	Apilimod (STA 5326) 是一种有效的、高度选择性的PIKfyve 抑制剂，是一种 IL-12/IL-23 的有效抑制剂，抑制人和猴的 PBMC 细胞中的 IL-12，IC50值为 1 nM 和 2 nM。
T1787	Levobupivacaine	Sodium Channel	Membrane transporter/Ion channel
	Levobupivacaine 是一种氨基酰胺类局麻药，属于n-alkylsubstituted pipecoloxylidide 家族。它是bupivacaine 的 S-对映异构体。
T6831	Etretinate Retinoid,Tegison,Etretinato,Ethyl etrinoate,Ro 10-9359,依曲替酯	Apoptosis; Others	Apoptosis; Others
	Etretinate (Ro 10-9359) 是一种口服芳香族维甲酸，对牛皮癣和其他皮肤病综合征有效。它激活类视黄醇受体，引起细胞分化的诱导、细胞增殖的抑制和炎症细胞对组织浸润的抑制。
T0029	Procaine Duracaine,Spinocaine,普鲁卡因,Novocaine,Vitamin H3,奴夫卡因	Histone Demethylase; DNA/RNA Synthesis; Sodium Channel	Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Membrane transporter/Ion channel
	Procaine (Vitamin H3) 是DNA 脱甲基剂，是一种酯类局部麻醉剂。它起效缓慢，作用持续时间短，主要用于浸润麻醉、周围神经阻滞和脊髓阻滞。
T8857	LJP-1586 HCl LJP 1586,LJP-1586 hydrochloride,LJP-1586,LJP1586	Others	Others
	LJP-1586 HCl 是一种高选择性的血管粘附蛋白-1（VAP-1）抑制剂，通过减少脑出血（ICH）后粘附分子表达和免疫细胞浸润而显示出抗炎作用。
T79185	STAT6-IN-2	STAT	JAK/STAT signaling; Stem Cells
	STAT6-IN-2 (Comp R-84) 是STAT6的一种抑制剂，能够抑制嗜酸粒细胞趋化因子-3的分泌，常用于免疫疾病研究。
T16379	Oglemilast GRC 3886	PDE	Metabolism
	Oglemilast (GRC 3886) 是一种具有口服活性磷酸二酯酶 4 (PDE4) 抑制剂，对 PDE4D3 的 IC50 为 0.5 nM。Oglemilast 在体外和体内抑制肺细胞浸润，包括嗜酸性粒细胞增多和嗜中性粒细胞减少。Oglemilast 具有应用于炎症性气道疾病的潜力。
T8732	CTPI-2	Others; Mitochondrial Metabolism	Metabolism; Others
	CTPI-2 是一种特异性线粒体柠檬酸盐载体SLC25A1抑制剂，KD=3.5 μM，具有抗肿瘤作用。它能够抑制糖酵解、PPARγ 及其下游靶点葡萄糖转运蛋白 GLUT4。它阻断非酒精性脂肪性肝炎逆转脂肪变性的显著改变，防止演变为脂肪性肝炎，减少肝脏和脂肪组织中炎性巨噬细胞的浸润，并显著减轻由高脂肪饮食引起的肥胖。
T61356	CXCR2 antagonist 3	Others	Others
	CXCR2 antagonist 3 (compound 11h) is a highly effective antagonist of CXC chemokine receptor 2 (CXCR2). It displays potent activity in inhibiting neutrophil infiltration into the air pouch, with double-digit nanomolar potencies against CXCR2. Moreover, CXCR2 antagonist 3 reduces the infiltration of neutrophils and MDSCs, while enhancing the infiltration of CD3+ T lymphocytes into Pan02 tumor tissues [1].
T25525	IDT	Others	Others
	IDT is an orally active TNFα modulator. It acts by altering neutrophil infiltration, improving cognition and diminishing tau and amyloid pathology in the 3xTgAD mouse model.
T76567	Met-RANTES (human)
	Met-RANTES (human) 为一部分CCR5拮抗剂，能够降低血液单核细胞向肝脏浸润的程度。
TP1379	KKI-5 TFA(97145-43-2 free base) KKI-5 (TFA)
	KKI-5 (TFA) is a specific tissue kallikrein inhibitor.Kki-5 (TFA) can reduce breast cancer cell infiltration.
T70107	Olcorolimus	Others	Others
	Olcorolimus inhibits single allergen-induced allergic inflammation such as eosinophilic and lymphocytic infiltration and mRNA expression for interleukin (IL)-4 and IL-5
T82642	Cyclo(RGDfK(Mal))
	Cyclo(RGDfK(Mal))为一种五肽，能促进人多能干细胞的附着与渗透，适用于三维干细胞培养及其扩增。
T80502	P4pal10
	P4pal10为PAR4拮抗剂，能在体内抑制凝血酶介导的小鼠血小板聚集，并显著减少Carrageenan引起的水肿及粒细胞浸润。
T37259	14(S)-HDHA	Others	Others
	Docosahexaenoic acid is a nutritionally-derived ω-3 fatty acid that is abundant in the brain and the retina and is thought to be important in early development and for therapeutic approaches to inflammatory disorders and cancer. 14(S)-HDHA is an oxygenation product of DHA that serves as a precursor to maresin 1 , an anti-inflammatory, pro-resolving mediator that prevents polymorphonuclear neutrophil (PMN) infiltration and stimulates macrophage phagocytosis. At doses as low as 0.2 ng/mouse 14(S)-...
T70874	Vipoglanstat	Others	Others
	Vipoglanstat is a prostaglandin E synthase inhibitor and an anti-inflammatory. Vipoglanstat ameliorates leukocyte infiltration and lung injury resulting from both endotoxin-induced and sepsis-induced lung injury.
T30215	AUY-954 free base AUY 954,NVP-AUY954,AUY-954,AUY954	Others	Others
	AUY-954 is an effective selective S1P(1) modulator. It can significantly reduce the local expression of EAN rat sciatic nerve T cells, B cells, macrophage infiltration, inflammatory demyelination, interleukin-17 and matrix metalloproteinase-9.
T33595	Naproxcinod AZD3582,Nitronaproxen,AZD-3582,Naproxen-N-butyl nitrate,HCT3012,AZD 3582	Others	Others
	Naproxcinod, a nitric oxide-releasing NSAID derivative, significantly improved skeletal muscle strength and fatigue resistance in sedentary and exercise mice, reducing inflammatory infiltration and fibrotic deposition in the myocardium and diaphragm. In a
T28933	TCV-309 TCV309	Others	Others
	TCV-309 is an inhibitor of platelet activating factor (PAF). TCV-309 reduces graft PMN infiltration and enhances early function of 24-hour-preserved rat kidneys with long warm ischemia. TCV-309 attenuates the priming effects of bronchoalveolar macrophages
T40958	Milategrast E6007	Others	Others
	Milategrast is a chemical compound that functions as a potent cell adhesion inhibitor and cell infiltration inhibitor. In vitro studies have demonstrated its ability to effectively inhibit the adhesion of Jurkat cells to human fibronectin, with an IC50 value of less than 5 μM.
T61599	XT2	Others	Others
	XT2 is a highly potent, orally active, and selective inhibitor of NF-κB-inducing kinase (NIK), exhibiting an IC50 of 9.1 nM. It effectively suppresses the upregulation of ALT, a vital biomarker for acute liver injury, induced by CCl4. Additionally, XT2 significantly decreases immune cell infiltration into the damaged liver tissue. As a result, XT2 holds immense potential in liver inflammatory disease research [1].
T38043	Resolvin E4	Others	Others
	Resolvin E4 (RvE4) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1It is produced from eicosapentaenoic acid by 15-lipoxygenase (15-LO)via15(S)-HpEPE and 15S-hydroxy, 5S-HpEPE intermediatesin vitroand by isolated human M2 macrophages or polymorphonuclear (PMN) neutrophils under normoxic or hypoxic conditions. RvE4 synthesis is enhanced in M2 macrophage and neutrophil co-cultures, indicating transcellular biosynthesis by a potential 15-LO and 5-LO mechanism...
T73520	TNG260	Others	Others
	TNG260 是一种CoREST 选择性脱乙酰酶(CoreDAC) 抑制剂。 TNG260 抑制HDAC1的选择性是HDAC3的 10 倍。 TNG260 导致HDAC1抑制，逆转由 STK11 缺失驱动的抗 PD1 耐药性。 TNG260 减少嗜中性粒细胞的瘤内浸润。 TNG260 表现出免疫介导的细胞杀伤。
T62927	HPK1-IN-22	Others	Others
	HPK1-IN-22 (compound ZYF0033) 是一种造血祖细胞激酶 1 (HPK1) 抑制剂，基于 MBP 蛋白的磷酸化抑制作用的 IC50小于 10 nM。HPK1-IN-22 能够减少 SLP76 (丝氨酸 376) 的磷酸化，促进抗癌免疫反应。HPK1-IN-22 可以抑制 4T-1 同基因小鼠模型中的肿瘤生长，增加 DC、NK 细胞和 CD107a+CD8+T 细胞的肿瘤内浸润，但会减少 T 细胞、PD-1+CD8+T 细胞、TIM-3+CD8+T 细胞和 LAG3+CD8+T 细胞的浸润。
T38042	Resolvin D4 Resolvin D4,RvD4	Others	Others
	Resolvin D4 (RvD4) is a specialized pro-resolving mediator derived from docosahexaenoic acid . [1] It has been detected in human milk, in the dorsal pouch of mice before and after infection with S. aureus, and in untreated tissues from humans, mice, and sardines.[2][3] RvD4, at 10 ng/mouse, reduces neutrophil infiltration in zymosan A-induced peritonitis and, at 200 ng/mouse, diminishes neutrophil infiltration in response to S. aureus infection. [3] With isolated cells, RvD4 promotes phagocytosi...
T62301	J-1063	Others	Others
	J-1063 是一种选择性、口服具有活力的、有效的 ALK5 抑制剂 (IC50: 0.039 μM)。 J-1063 能够抑制炎症浸润，胶原沉积，肝细胞坏死，表现出抗肝纤维化作用。J-1063 具有潜力进行肝纤维化的研究。
T70346	TOP1362	Others	Others
	TOP1362 is a Narrow Spectrum Kinase Inhibitors Demonstrate Promise for the Treatment of Dry Eye Disease and Other Ocular Inflammatory Disorders. TOP1362 strongly inhibited the kinase targets p38α, Syk, Src, and Lck, blocked the rise in p38α expression in hyperosmolar Chang cells, and potently reduced inflammatory cytokine release in cellular models of innate and adaptive immunities. In the EIU model, TOP1362 dose-dependently attenuated the LPS-induced rise in inflammatory cell infiltration and o...
T77163	Pexelizumab
	Pexelizumab (h5G1.1-SC)为一种针对C5补体成分的人源化单克隆抗体。该化合物可抑制凋亡(apoptosis)和白细胞浸润，常用于研究脑缺血再灌注损伤和心肌梗死。
T76983	Tengonermin
	Tengonermin (ARENEGYR) 是一种血管靶向剂，由与CNGRCG 肽结合的人肿瘤坏死因子-α (TNF-α) 组成。Tengonermin 通过改变肿瘤微环境来增加肿瘤内化疗的渗透和 T 细胞浸润。
T84937	1,1'-Ethylidene-bis-(L-tryptophan) Peak 97 Contaminant	Others	Others
	1,1'-Ethylidene-bis-(L-tryptophan) is a potential impurity in L-tryptophan commercial products, promoting EoL-3 eosinophilic leukemia cell proliferation, enhancing eosinophil cationic protein release from human peripheral blood eosinophils, and boosting IL-5 production in human T cells. At 40 µg/kg, it triggers fascia thickening, mast cell infiltration, inflammation, and fibrosis in mouse superficial adipose and panniculus carnosus tissues, serving as an eosinophilia-myalgia syndrome research mo...
T84455	17(R)-Resolvin D1 methyl ester Aspirin-triggered-Resolvin D1 methyl ester	Others	Others
	17(R)-Resolvin D1 (17(R)-RvD1) is an aspirin-triggered epimer of RvD1 that equivalently inhibits human polymorphonuclear leukocyte migration across the endothelium (EC50= ~30 nM), a precursor to acute inflammation. Unlike RvD1, it resists rapid degradation by eicosanoid oxidoreductases. In a mouse peritonitis model, 17(R)-RvD1 dose-dependently reduces leukocyte infiltration, achieving up to a 35% decrease with a 100 ng dose. Additionally, its methyl ester derivative, designed to enhance its phar...
T38384	Nexinhib20	Others	Others
	Nexinhib20 is an inhibitor of the protein-protein interaction between the small GTPase Rab27a and its effector JFC1 (IC50 = 2.6 μM).[1] It inhibits myeloperoxidase (MPO) secretion induced by granulocyte macrophage colony-stimulating factor (GM-CSF) and fMLP in isolated human neutrophils (IC50 = 0.33 μM). Nexinhib20 (30 mg/kg) reduces LPS-induced increases in plasma MPO levels, as well as LPS-induced hepatic and renal neutrophil infiltration in a mouse model of endotoxin-induced systemic inflamma...
T72668	PD-1/PD-L1-IN-26	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	PD-1/PD-L1-IN-26 (Compound II-14) 是一种高效的 PD-1/PD-L1 抑制剂，IC50 为 0.0380 μM。该化合物能够激活肿瘤免疫微环境，通过促进 CD4+ T 细胞向肿瘤组织的浸润。PD-1/PD-L1-IN-26 展示了在癌症治疗研究中的应用潜力。
T79643	PD-1/PD-L1-IN-33	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	PD-1/PD-L1-IN-33 (Compound N11) 是抑制PD-1与PD-L1相互作用的抑制剂，IC50 值为 6.3 nM。该化合物能够促进T细胞的增殖、激活以及浸润肿瘤球，显示出免疫调节和抗肿瘤的活性。
T84912	PD1-PDL1-IN 2	Others	Others
	PD1-PDL1-IN 2 是一种高效且选择性的PD-1/PD-L1抑制剂，在体内展现出显著的抗肿瘤活性。该化合物能够促进细胞毒性T细胞对肿瘤的浸润并诱导IL-2的表达，同时对TGF-β mRNA的表达亦具有强烈的抑制效果。
T69230	AZD-1236	Others	Others
	AZD1236 is a potent and reversible inhibitor of human MMP-9 and MMP-12 (IC50 = 4.5 and 6.1nM, respectively), with >10-fold selectivity to MMP-2 and MMP-13 and >350-fold selectivity to other members of the enzyme family. AZD1236 activity is approximately 20 to 50-fold lower at the rat, mouse, and guinea pig orthologues. In acute models of lung injury, AZD1236 inhibited the haemorrhage and inflammation induced by instillation of human MMP-12 into rat lungs by ~80% at 0.81mg/kg, and also abolished ...
T37506	MCTR2 MCTR2	Others	Others
	Maresin conjugates in tissue regeneration 2 (MCTR2) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages at the site of inflammation. DHA is oxidized to maresin 1 , which is converted to MCTR1 by glutathione S-transferase Mu 4 or leukotriene C4 synthase then to MCTR2 by γ-glutamyl transferase. MCTR2 accelerates tissue regeneration in planaria (1 and 100 nM). Pretreatment with MCTR2 prior to E. coli administration reduces neutrophil infiltration, shor...
T85331	S‐Y048 S Y048,(S)‐Y048
	S-Y048 是一种高效、选择性的 OXE 受体拮抗剂，可抑制 5‐oxo‐ETE 诱导的人类中性粒细胞的钙动员，pIC50 为 10.8（20 pM），还可抑制过敏原诱导的嗜酸性粒细胞浸润到对屋尘螨敏感的恒河猴皮肤中以及由气溶胶过敏原刺激引起的肺部炎症。
T37503	Maresin 2 3R,14S-diHDHA	Others	Others
	Docosahexaenoic acid is an ω-3 fatty acid that is abundant in the brain and the retina and is known to be important in early development.[1] [2] Maresin 2 (MaR2) is a 13R,14S-dihydroxy DHA formed by recombinant human macrophage 12-lipoxygenase and soluble epoxide hydrolase co-incubated with DHA. [3] At 1 ng/mouse, MaR2 was shown to reduce neutrophil infiltration by 40% in a mouse model of peritonitis, and at 10 pM, MaR2 can enhance human macrophage phagocytosis of zymosan A by 90%. [3] Analytica...
TP2514	BPC 157 acetate Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val,GEPPPGKPADDAGLV	Others	Others
	Body Protection Compound 157 (BPC 157) is a pentadecapeptide derived from BPC, identified in gastric juice, exhibiting diverse biological activities. At 2 µg/ml, BPC 157 enhances primary rat tendon fibroblast cell migration and F-actin formation. Furthermore, doses of 0.01 and 10 µg/kg, intraperitoneally (i.p.), mitigate paw swelling, bone erosion, and mononuclear cell infiltration in the joints of rats with rheumatoid arthritis induced by complete Freund's adjuvant (CFA). It also diminishes gas...
T76786	Cabiralizumab
	Cabiralizumab (FPA 008) 是一种抗 CSF1R 单克隆抗体 (MAb)。Cabiralizumab 可增强 T 细胞浸润和抗肿瘤 T 细胞免疫反应。Cabiralizumab 抑制破骨细胞的活化并阻止骨质破坏，可用于类风湿性关节炎 (RA) 的研究。Cabiralizumab 可与 Nivolumab 结合用于肺癌研究。
T38350	TAS 205	Others	Others
	TAS 205 is an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS; IC50= 55.8 nM).1It is selective for H-PGDS over lipocalin-type PGDS (L-PGDS) at 100 μM, as well as over enzyme and receptor panels at 10 μM. TAS 205 inhibits production of prostaglandin D2induced by A23187 in KU812 human and RBL-2H3 rat basophils with IC50values of 78.3 and 181.3 nM, respectively. It inhibits ovalbumin-induced nasal lavage fluid eosinophil infiltration and late-phase nasal obstruction in an ovalbumin-sens...
T37505	MCTR1 MCTR1	Others	Others
	Maresin conjugates in tissue regeneration 1 (MCTR1) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages at the site of inflammation. DHA is oxidized to maresin 1 , which is then converted to MCTR1 by glutathione S-transferase Mu 4 or leukotriene C4 synthase. MCTR1 accelerates tissue regeneration in planaria (1 and 100 nM). Pretreatment with MCTR1 (50 ng/mouse, i.p.) prior to E. coli administration reduces neutrophil infiltration, shortens the inflam...

化合物

Cat.No: T8844

Target: Others, FLAP, Epoxide Hydrolase

Cat.No: T8313

Target: Others

Cat.No: T9043

Target: P450, STAT

Doxylamine succinate

Cat.No: T1115

Synonym: 琥珀酸多西拉敏,Decapryn

Target: Histamine Receptor

Mepivacaine hydrochloride

Cat.No: T0946

Synonym: Mepivacaine HCl,盐酸甲哌卡因

Target: Sodium Channel

Cat.No: T35367

Synonym: TAA,硫代乙酰胺

Target: Others

Cat.No: T2018

Synonym: 阿匹莫德,阿吡莫德,STA 5326

Target: IL Receptor, PI3K, Interleukin

Levobupivacaine

Cat.No: T1787

Target: Sodium Channel

Cat.No: T6831

Synonym: Retinoid,Tegison,Etretinato,Ethyl etrinoate,Ro 10-9359,依曲替酯

Target: Apoptosis, Others

Cat.No: T0029

Synonym: Duracaine,Spinocaine,普鲁卡因,Novocaine,Vitamin H3,奴夫卡因

Target: Histone Demethylase, DNA/RNA Synthesis, Sodium Channel

Cat.No: T8857

Synonym: LJP 1586,LJP-1586 hydrochloride,LJP-1586,LJP1586

Target: Others

Cat.No: T79185

Target: STAT

Cat.No: T16379

Synonym: GRC 3886

Target: PDE

Cat.No: T8732

Target: Others, Mitochondrial Metabolism

CXCR2 antagonist 3

Cat.No: T61356

Target: Others

Cat.No: T25525

Target: Others

Met-RANTES (human)

Cat.No: T76567

KKI-5 TFA(97145-43-2 free base)

Cat.No: TP1379

Synonym: KKI-5 (TFA)

Cat.No: T70107

Target: Others

Cyclo(RGDfK(Mal))

Cat.No: T82642

Cat.No: T80502

Cat.No: T37259

Target: Others

Cat.No: T70874

Target: Others

AUY-954 free base

Cat.No: T30215

Synonym: AUY 954,NVP-AUY954,AUY-954,AUY954

Target: Others

Cat.No: T33595

Synonym: AZD3582,Nitronaproxen,AZD-3582,Naproxen-N-butyl nitrate,HCT3012,AZD 3582

Target: Others

Cat.No: T28933

Synonym: TCV309

Target: Others

Cat.No: T40958

Synonym: E6007

Target: Others

Cat.No: T61599

Target: Others

Cat.No: T38043

Target: Others

Cat.No: T73520

Target: Others

Cat.No: T62927

Target: Others

Cat.No: T38042

Synonym: Resolvin D4,RvD4

Target: Others

Cat.No: T62301

Target: Others

Cat.No: T70346

Target: Others

Cat.No: T77163

Cat.No: T76983

1,1'-Ethylidene-bis-(L-tryptophan)

Cat.No: T84937

Synonym: Peak 97 Contaminant

Target: Others

17(R)-Resolvin D1 methyl ester

Cat.No: T84455

Synonym: Aspirin-triggered-Resolvin D1 methyl ester

Target: Others

Cat.No: T38384

Target: Others

PD-1/PD-L1-IN-26

Cat.No: T72668

Target: PD-1/PD-L1

PD-1/PD-L1-IN-33

Cat.No: T79643

Target: PD-1/PD-L1

Cat.No: T84912

Target: Others

Cat.No: T69230

Target: Others

Cat.No: T37506

Synonym: MCTR2

Target: Others

Cat.No: T85331

Synonym: S Y048,(S)‐Y048

Cat.No: T37503

Synonym: 3R,14S-diHDHA

Target: Others

BPC 157 acetate

Cat.No: TP2514

Synonym: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val,GEPPPGKPADDAGLV

Target: Others

Cat.No: T76786

Cat.No: T38350

Target: Others

Cat.No: T37505

Synonym: MCTR1

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T3662	Eleutheroside E	NF-κB	NF-κB
	Eleutheroside E 是刺五加的重要成分，具有抗炎，保护缺血心脏的功能。
T16733	Resolvin E1 RvE1	Others	Others
	Resolvin E1 is an effective endogenous pro-resolving mediator of inflammation. Resolvin E1 has unique counterregulatory actions that inhibit PMN transendothelial migration. Resolvin E1 also acts as an effective inhibitor of leukocyte infiltration, dendrit
TN4582	Moracin T	c-Myc; COX	Cell Cycle/Checkpoint; Immunology/Inflammation; Neuroscience
	Moracin treatment can inhibit the double 12-O-tetradecanoylphorbol 13-acetate (TPA) treatment-induced morphological changes reflecting inflammatory response, including leucocyte infiltration, hyperplasia and cell proliferation; moracin treatment furthermo
T83916	Cytogenin	Others	Others
	Cytogenin（一种源自S. eurocidicum的香豆素衍生物）具有多种生物活性。在每日给药25 mg/kg剂量下，能减轻Ehrlich鼠自发性腺癌模型的肿瘤重量。在体内，Cytogenin（每日30和100 mg/kg）可减少链脲佐菌素诱导的体重下降和血浆葡萄糖水平上升，以及小鼠糖尿病模型中巨噬细胞胰腺浸润。同时，在每日100 mg/kg的剂量下，能降低小鼠巨噬细胞中zymosan和LPS诱导的一氧化氮产生，及LPS诱导的Il-6水平增加。

天然产物

Eleutheroside E

Cat.No: T3662

Target: NF-κB

Cat.No: T16733

Synonym: RvE1

Target: Others

Cat.No: TN4582

Target: c-Myc, COX

Cat.No: T83916

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00641	LEC/CCL16 Protein, Human, Recombinant (His) SCYL4,HCC-4,ILINCK,LMC,SCYA16,NCC-4,CKb12,Mtn-1,LCC-1,LEC,ch...	Human	E. coli
	CCL16, a chemokine poorly characterized at the functional level. Human CCL16 is a member of the CC family, and its gene maps to human chromosome 17q. In the mouse, only a pseudogene has been identified to date. CCL16 is a functional ligand for CCR1, CCR2, CCR5, and CCR8. Recombinant CCL16 demonstrated chemotactic activity on human monocytes and lymphocytes. Based on the ability of human chemokines to exert activity on and bind to murine receptors, the TSA mouse adenocarcinoma cell line was trans...
TMPY-04984	CXCL17 Protein, Human, Recombinant (His) Dcip1,UNQ473,DMC,VCC1,chemokine (C-X-C motif) ligand 17,VCC-...	Human	P. pastoris (Yeast)
	Chemokine (C-X-C motif) ligand 17 (CXCL17) is the latest member of the chemokine family. CXCL17 is a potential oncogene and promising therapeutic target, is an independent biomarker of poor prognosis in patients with breast cancer, and can promote proliferation and migration of breast cancer cells in vitro and in vivo. CXCL17 is expressed in a variety of cancers and promotes tumor progression by recruiting myeloid-derived suppressor cells (MDSCs). CXCL17 attenuates IMQ-induced psoriasis-like ski...
TMPY-02125	CCL6 Protein, Mouse, Recombinant (His) Scya6,MRP-1,c10,RP23-320E6.4,chemokine (C-C motif) ligand 6	Mouse	HEK293 Cells
	Chemokine (C-C motif) ligand 6 (CCL6), also known as C-C chemokine C10 has only been identified in rodents, which is a small cytokine belonging to the CC chemokine family, beta-chemokine subfamily. C-C chemokine C10 is involved in the chronic stages of host defense reactions. C10 chemokine rapidly promotes disease resolution in the cecal ligation and puncture (CLP) model through its direct effects on the cellular events critically involved in host defense during septic peritonitis. CCL6 appears ...
TMPY-02210	Serpin B9 Protein, Human, Recombinant (His) CAP-3,PI-9,CAP3,PI9,serpin peptidase inhibitor, clade B (ova...	Human	Baculovirus Insect Cells
	SerpinB9, also known as Cytoplasmic antiproteinase 3, CAP-3, Peptidase inhibitor 9, SERPINB9 and PI-9, is a cytoplasm protein that belongs to the serpin family and Ov-serpin subfamily. Serpin-B9 ( CAP-3 / PI-9 ) is the only known human intracellular inhibitor of granzyme B (GrB), the effector molecule in immunity against cytomegalovirus (CMV) and in renal allograft rejection. Serpin-B9 and SPI-6 expression in immune-privileged cells, APCs, and CTLs protect these cells against the actions of gran...
TMPY-01654	ITCH Protein, Human, Recombinant (aa 526-903) itchy E3 ubiquitin protein ligase,NAPP1,dJ468O1.1,ADMFD,AIF4...	Human	E. coli
	E3 ubiquitin-protein ligase Itchy homolog, also known as Atrophin-1-interacting protein 4, NFE2-associated polypeptide 1, NAPP1, and ITCH, is a cell membrane protein that contains one C2 domain, one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and contains four WW domains. ITCH acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It catalyzes 'Lys-...

重组蛋白

LEC/CCL16 Protein, Human, Recombinant (His)

Cat.No: TMPY-00641

Species: Human

Expression System: E. coli

CXCL17 Protein, Human, Recombinant (His)

Cat.No: TMPY-04984

Species: Human

Expression System: P. pastoris (Yeast)

CCL6 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02125

Species: Mouse

Expression System: HEK293 Cells

Serpin B9 Protein, Human, Recombinant (His)

Cat.No: TMPY-02210

Species: Human

Expression System: Baculovirus Insect Cells

ITCH Protein, Human, Recombinant (aa 526-903)

Cat.No: TMPY-01654

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T71329	Theophylline-d6
	Theophylline-d6 is intended for use as an internal standard for the quantification of theophylline by GC- or LC-MS. Theophylline is an inhibitor of phosphodiesterase. It is also an adenosine A1 and A2 receptor antagonist. Theophylline induces relaxation of isolated cat bronchial smooth muscle segments precontracted with acetylcholine. It inhibits ovalbumin-induced increases in bronchoalveolar lavage fluid (BALF) eosinophil infiltration in an ovalbumin-sensitized mouse model of allergic asthma. F...

同位素标记化合物

Theophylline-d6

Cat.No: T71329

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