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Search Results for " hypersensitivity "

Targets Recommended: Sodium Channel

45

抑制剂 & 化合物

7

天然产物

1

化合物库

9

重组蛋白

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Cat. No.	Product Name
L5510	肝脏毒性化合物库		1001 compounds
	1001 个肝脏毒性化合物的特有集合，可用于高通量、高内涵筛选，是毒理学研究的良好工具；

化合物库

肝脏毒性化合物库

Cat.No: L5510

Compounds: 1001

Cat. No.	Product Name	Target	Signaling Pathways
T9685	DS-1971a	Sodium Channel	Membrane transporter/Ion channel
	DS-1971a 是选择性、口服有效的 NaV1.7抑制剂，对 hNaV1.7 和 mNaV1.7 的 IC50分别为 22.8 和 59.4 nM。DS-1971a 在缓解疼痛方面有研究价值。
T4563	Thonzylamine neohetramine,松齐拉敏	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Thonzylamine (neohetramine) 是可口服的H1组胺受体拮抗剂，具有抗组胺和抗过敏特性，可用于鼻充血、过敏性结膜炎和其他过敏性疾病的研究。
T5491	GSK3179106	c-RET	Apoptosis; Tyrosine Kinase/Adaptors
	GSK3179106 是选择性的、具有口服活性的RET 激酶抑制剂，对人和大鼠 RET 的 IC50 分别为 0.4 nM 和 0.2 nM。它能够减轻炎症后和应激引起的内脏超敏反应，对肠易激综合征具有潜在的应用价值。
T14984	CLP257	Potassium Channel	Membrane transporter/Ion channel
	CLP257 是有效的 K+-Cl- 协同转运蛋白 KCC2 选择性激活剂 (EC50: 616 nM)。它可减轻神经性疼痛大鼠的超敏反应，并在翻译后调节质膜 KCC2 蛋白周转。它在 KCC2 活性降低的神经元中恢复受损的 Cl- 转运。
T14127	Adenosine A1 receptor activator T62	Adenosine Receptor	GPCR/G Protein; Neuroscience
	Adenosine A1 receptor activator T62 是腺苷 A1 受体的变构增强剂，有镇痛作用。
T1824	TGR5 Receptor Agonist	GPCR19	GPCR/G Protein
	TGR5 Receptor Agonist 是一种TGR5(GPCR19)激动剂。
T21472	Dimethindene maleate 马来酸二甲茚定,UNII-6LL60J9E0O,SU 6518,SU-6518	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Dimethindene maleate (SU 6518) 是一种组胺 H1 拮抗剂，可用于治疗过敏反应、瘙痒和鼻炎的研究。
T124635	Cyclo(L-Pro-L-Ile)
	Cyclo(L-Pro-L-Ile) 是一种来自苏云金芽孢杆菌双酮哌嗪，可诱发中度超敏反应，可用于研究松树枯萎病。
T27178	Dimiracetam NT-11624,NT11624,BND11624,ISF4185,BND-11624,ISF-4185	Others	Others
	Dimiracetam (NT-11624) 是一种具有口服活性的抗神经病变化合物，可抑制过敏和神经改变，可用于研究认知障碍、抑郁症和神经性疼痛。
T15192	Eact	Chloride channel	Membrane transporter/Ion channel
	Eact 是一种选择性和有效的 TMEM16A 激活剂，可直接激活感觉伤害感受器中的 TRPV1 通道，还会产生瘙痒、急性伤害感受和热过敏。
T36478	BI-6901	CCR	Immunology/Inflammation; Microbiology/Virology
	BI-6901 是一种选择性 CCR10 拮抗剂。在DNFB接触超敏反应的小鼠模型中，BI 6901 以剂量依赖的方式显示其抗炎反应。
T77340L	AB21 HCl	Sigma receptor	GPCR/G Protein
	AB21 HCl 是 σ1 受体的选择性拮抗剂，σ1 受体的 Ki 为 13 nM，σ2 受体的 Ki 为 102 nM。 AB21 HCl 具有降低机械过敏的能力。
T16448	PD173212	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	PD 173212是一种阻断 N-型电压敏感性钙通道 (N-type voltage sensitive calcium channel, Cav2.2)的阻滞剂。PD173212的腹腔注射给药(0.0017-1.7 μmol/kg)显著降低了2,4-二硝基苯磺酸(DNBS)诱导结肠炎小鼠的内脏超敏反应。
T16240	N,N'-Diacetyl-L-cystine (Ac-Cys-OH)2,DiNAC	Others	Others
	N,N'-Diacetyl-L-cystine (DiNAC) 是一种具有免疫调节特性的 N-乙酰基半胱氨酸的二硫二聚体。它在高脂血症兔中也具有抗动脉粥样硬化的作用。它是啮齿类动物中接触敏感/迟发型超敏反应的有效口服活性调节剂。
T3627	IQ-1S free acid IQ-1,IQ-1S,IQ-1S (free acid)	NF-κB; JNK	MAPK; NF-κB
	IQ-1S free acid (IQ-1S) 是 NF-κB/激活蛋白1 (AP-1) 抑制剂(IC50:2.3±0.41 μM)。它对 JNK1(Kd:240 nM)、JNK2(Kd:360 nM) 和 JNK3(Kd:100 nM)的都具有高的结合亲和力。
T19839	Oxatomide Oxatomida	P2X Receptor; Calcium Channel; 5-HT Receptor; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Oxatomide (Oxatomida) 是一种有效且具有口服活性的双重 H1 组胺受体和 P2X7 受体双重拮抗剂，具有抗组胺和抗过敏活性。Oxatomide 可用于阻断人 P2X7 受体中 ATP 诱导的电流，IC50 为 0.95 μM。Oxatomide 对 ATP 诱导的 Ca2+ 内流具有抑制作用，IC50 值为 0.43 μM。Oxatomide 对 5-羟色胺具有抑制作用。Oxatomide可用于治疗免疫系统疾病和研究超敏反应。
T15096	Delgocitinib JTE-052,迪高替尼,Corectim（Delgocitinib）	Tyrosine Kinases; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Delgocitinib（JTE-052）是一种特异性的JAK（Janus激酶）抑制剂，其对JAK1、JAK2、JAK3 和 Tyk2 的 IC50 值分别为 2.8、2.6、13 和 58 nM。Delgocitinib 通过JAK-依赖性细胞因子参与多种炎症和自身免疫性疾病，能有效地遏制多种细胞因子信号传递，同时抑制了因细胞因子而引发的瘙痒。它可广泛用于治疗各种炎症性疾病，包括自身免疫性疾病和超敏反应。
T24771	SCH-336 SCH336,SCH 336	Cannabinoid Receptor	GPCR/G Protein
	SCH-336是一种 CB2受体激动剂(Ki-1.8 nM, EC50-2 nM)，具有有效性，选择性和口服活性。SCH-336对 CB1受体也具有生物活性，对CB2受体的选择性是CB1的100倍。SCH-336能够减少鸟苷5'-3- o -(硫)三磷酸与含hCB 的膜的结合，抑制 BaF3/CB2 细胞迁移，抑制小鼠延迟型超敏反应模型中的白细胞迁移，抑制小鼠过敏模型中抗原诱导的肺嗜酸性粒细胞增多。
T71716	Nav1.1-IN-B	Others	Others
	Nav1.1-IN-B is a selective NaV1.1 inhibitor which reduces visceral hypersensitivity.
T71308	DSP-6952	Others	Others
	DSP-6952 is a 5-HT4 receptor partial agonist, inhibiting visceral hypersensitivity and ameliorating gastrointestinal dysfunction.
T15167	Draflazine R-75231	Others	Others
	Draflazine is an ENT1 inhibitor. It completely reverses the hypersensitivity in the complete Freund’s adjuvant (CFA) model of mechanical hyperalgesia. Draflazine also completely reverses the hypersensitivity of the carrageenan inflammation model of therma
T71310	DS 4574	Others	Others
	DS 4574 is a peptidoleukotriene receptor antagonist used in treatment of hypersensitivity.
T31126	CX-659S CX659S,UNII-YG2F04AVMQ,CX 659S	Others	Others
	CX-659S is a novel diaminuracil derivative that indirectly inhibits Langerhans cell function by blocking the MEK1/2 -- ERK1/2 pathway in keratinocytes. CX-659S can inhibit the contact hypersensitivity induced by haptens in mice.
T69431	A-420983	Others	Others
	A-420983 is a novel potent Lck inhibitor, exhibiting oral efficacy in animal models of delayed-type hypersensitivity and organ transplant rejection.
T71938	MNF	Others	Others
	MNF, also known as 3,4-MNF, is an antagonist of the aryl hydrocarbon receptor (AhR). MNF reduces UVR-mediated immunosuppression and induces Tregs in murine contact hypersensitivity (CHS).
TP1339	OVA Peptide 323-339
	OVA Peptide (323-339) represents a T and B cell epitope of Ovalbumin (Ova), which play an important role in the development and development of immediate hypersensitivity in BALB/c mice.
T69950	Delgocitinib EtOH	Others	Others
	Delgocitinib, also known as LEO-124249 and JTE052, is a potent and selective JAK inhibitor. JTE-052 reduces skin inflammation and ameliorates chronic dermatitis in rodent models: Comparison with conventional therapeutic agents. JTE-052 regulates contact hypersensitivity by downmodulating T cell activation and differentiation.
T80501	Myr-TAT-CBD3	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Myr-TAT-CBD3是CRMP2-CaV2.2交互作用的抑制剂，有效减弱角叉菜胶诱导的热超敏反应，并能逆转大鼠术后疼痛模型的热超敏反应，适用于炎症和术后疼痛研究。
T70340	JHU-58	Others	Others
	JHU-58 is a novel dipeptide MrgC agonist. JHU-58 inhibited both mechanical and heat hypersensitivity in rats after an L5 spinal nerve ligation (SNL). JHU58 attenuated the evoked excitatory postsynaptic currents in substantia gelatinosa (SG) neurons in wild-type mice, but not in Mrg knockout mice, after peripheral nerve injury.
T78000	OVA Peptide (323-339)
	OVA Peptide (323-339) 是卵清蛋白(OVA)的T和B细胞表位，对BALB/c小鼠的瞬时超敏反应生成与发展至关重要。
T71053	AHR-5333 mandelate	Others	Others
	AHR-5333 mandelate is an anti-allergy compound which has been shown to protect against antigen-induced anaphylactic collapse and ascaris antigen-induced skin hypersensitivity. AHR-5333 mandelate has also been shown to inhibit 5-HETE, LTB4 and LTC4 synthesis.
T73433	MS47134	Others	Others
	MS47134是一种MRGPRX4激动剂，具有高效性和选择性，其EC50为149 nM。该化合物可应用于疼痛、瘙痒以及肥大细胞介导的超敏反应研究。
T78923	DDO-8926	Epigenetic Reader Domain	Chromatin/Epigenetic
	DDO-8926 是一种高效的选择性BET抑制剂，其通过抑制促炎细胞因子表达和降低神经兴奋性，显著减缓机械性超敏反应，被应用于神经性疼痛的研究领域。
T78916	AB21 oxalate	Sigma receptor	GPCR/G Protein
	AB21 oxalate为选择性S1R拮抗剂，对S1R的Ki为13 nM，对S2R为102 nM，能有效降低机械超敏反应。
T38326	Cromolyn (sodium salt hydrate)	Others	Others
	Cromolyn is a chromone complex that acts as a mast cell stabilizer, preventing the release of histamine. Its mechanism of action is thought to involve an interference with the antigen-stimulated calcium transport across the mast cell membrane, thereby inhibiting mast cell release of histamine, leukotrienes, and other substances that cause hypersensitivity reactions.
T83213	AC-099	Others	Others
	AC-099 hydrochloride（化合物 3）作为NPFF2R的选择性全激动剂（EC50=1189 nM）和NPFF1R的部分激动剂（EC50=2370 nM），可降低大鼠脊神经结扎引起的痛觉超敏。
T67212	Ligustrazine HCl	Others	Others
	Ligustrazine Hydrochloride, is a natural substance discovered in the plant Ligusticum chuanxiong Hort. It inhibits platelet aggregation, improves atherosclerosis situation, protects endothelium injury, and has antithrombotic effects.in vivo,ligustrazine hydrochloride at 10 and 20 mg/kg produced significant analgesic effects against mechanical stimuli,and ligustrazine hydrochloride at 80 mg/kg, also significantly alleviated cold hypersensitivity manifested by reduction in cold vocalization temper...
T60289	Pemirolast	Others	Others
	Pemirolast 是一种具有口服活性的抗过敏剂。Pemirolast 通过抑制感觉神经肽的释放来减轻紫杉醇超敏反应，可用于对支气管哮喘和结膜炎的研究。
T35461	δ14-Triamcinolone acetonide	Others	Others
	δ14-Triamcinolone acetonide is a potential impurity found in commercial preparations of triamcinolone acetonide. Triamcinolone acetonide is a synthetic corticosteroid. It decreases cytokine levels, the firing rate of sensory neurons, and mechanical hypersensitivity in a rat spinal nerve ligation model when used at a dose of 1.5 mg/kg prior to and following surgery for three days. Triamcinolone acetonide also decreases outflow facility in a mouse model of steroid-induced glaucoma when 20 μl of a ...
T21916	TC-SP 14	Others	Others
	TC-SP 14, also known as compound 14, is a highly active and potent S1P1 agonist with oral bioavailability. It exhibits an EC50 value of 0.042 μM, indicating its strong binding affinity to the S1P1 receptor. Notably, its interaction with the S1P3 receptor is minimal, as evidenced by an EC50 value of 3.47 μM. TC-SP 14 demonstrates significant pharmacological effects, including a marked reduction in blood lymphocyte counts and the attenuation of delayed type hypersensitivity response to antigen cha...
T37167	Reduced Haloperidol	Others	Others
	Reduced haloperidol is an active metabolite of haloperidol . It is formed via reduction of haloperidol by ketone reductase. Reduced haloperidol inhibits radioligand binding to sigma-1 and dopamine D2 receptors (Kis = 1.4 and 31 nM, respectively) and stimulates brain-derived neurotrophic factor (BDNF) secretion from CCF-SSTG1 and U87MG astrocytic glial cells. It also inhibits norepinephrine, dopamine, and serotonin (5-HT) reuptake (Kis = 21, 25, and 33 μM, respectively, in COS-7 cells expressing ...
T37620	Leukotriene C4 methyl ester	Others	Others
	Leukotriene C4 (LTC4) is the parent cysteinyl-leukotriene produced by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, and mast cells, and by transcellular metabolism in platelets. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute all...
T31657	Epothilone F	Others	Others
	Epothilone F is a derivative or analogue of Epothilone D. Epothilone F is also an active metabolite of Epothilone D. In molecule of Epothilone F, a hydroxymethyl group is on the thiazole ring. Like taxanes, Epothilone F prevents cancer cells from dividing
T36851	Peptide5
	Connexin43 mimetic peptide. Reduces swelling, astrogliosis, neuroinflammation and neuronal cell death following spinal cord injury ex vivo and in vivo. Exhibits analgesic effects in models of neuropathic pain. O'Carroll et al (2008) Connexin 43 mimetic peptides reduce swelling, astrogliosis and neuronal cell death after spinal cord injury. Cell.Commun.Adhes. 15 27 PMID:18649176 \|Mao et al (2017) Characterisation of Peptide5 systemic administration for treating traumatic spinal cord injured rats....
T83731	Tat-CBD3 TFA
	Tat-CBD3是一种抑制N型电压门控钙通道Cav2.2与collapsin response mediator protein 2 (CRMP2)之间的蛋白质-蛋白质相互作用的抑制剂。它还能抑制CRMP2与NMDA受体NR2B亚单位之间的蛋白质-蛋白质相互作用。在无细胞实验中，Tat-CBD3 (10 µM)能将Cav2.2-CRMP2相互作用抑制43%，并在免疫共沉淀实验中抑制NMDA受体NR2B亚单位-CRMP2相互作用。它能在初级大鼠背根神经节 (DRG) 神经元中减少约60%的电压诱导钙电流，并在初级大鼠海马神经元中减少谷氨酸诱导的胞内钙水平增加。Tat-CBD3 (20 mg/kg)在大鼠中脑动脉闭塞 (MCAO) 引发的脑缺血模型中减少梗死体积。鞘内给药Tat-CBD3 (20 µg/5 µl)可防止大鼠卡拉胶诱导的热敏感性。

化合物

Cat.No: T9685

Target: Sodium Channel

Cat.No: T4563

Synonym: neohetramine,松齐拉敏

Target: Histamine Receptor

Cat.No: T5491

Target: c-RET

Cat.No: T14984

Target: Potassium Channel

Adenosine A1 receptor activator T62

Cat.No: T14127

Target: Adenosine Receptor

TGR5 Receptor Agonist

Cat.No: T1824

Target: GPCR19

Dimethindene maleate

Cat.No: T21472

Synonym: 马来酸二甲茚定,UNII-6LL60J9E0O,SU 6518,SU-6518

Target: Histamine Receptor

Cyclo(L-Pro-L-Ile)

Cat.No: T124635

Cat.No: T27178

Synonym: NT-11624,NT11624,BND11624,ISF4185,BND-11624,ISF-4185

Target: Others

Cat.No: T15192

Target: Chloride channel

Cat.No: T36478

Target: CCR

Cat.No: T77340L

Target: Sigma receptor

Cat.No: T16448

Target: Calcium Channel

N,N'-Diacetyl-L-cystine

Cat.No: T16240

Synonym: (Ac-Cys-OH)2,DiNAC

Target: Others

IQ-1S free acid

Cat.No: T3627

Synonym: IQ-1,IQ-1S,IQ-1S (free acid)

Target: NF-κB, JNK

Cat.No: T19839

Synonym: Oxatomida

Target: P2X Receptor, Calcium Channel, 5-HT Receptor, Histamine Receptor

Cat.No: T15096

Synonym: JTE-052,迪高替尼,Corectim（Delgocitinib）

Target: Tyrosine Kinases, JAK

Cat.No: T24771

Synonym: SCH336,SCH 336

Target: Cannabinoid Receptor

Cat.No: T71716

Target: Others

Cat.No: T71308

Target: Others

Cat.No: T15167

Synonym: R-75231

Target: Others

Cat.No: T71310

Target: Others

Cat.No: T31126

Synonym: CX659S,UNII-YG2F04AVMQ,CX 659S

Target: Others

Cat.No: T69431

Target: Others

Cat.No: T71938

Target: Others

OVA Peptide 323-339

Cat.No: TP1339

Delgocitinib EtOH

Cat.No: T69950

Target: Others

Cat.No: T80501

Target: Calcium Channel

Cat.No: T70340

Target: Others

OVA Peptide (323-339)

Cat.No: T78000

AHR-5333 mandelate

Cat.No: T71053

Target: Others

Cat.No: T73433

Target: Others

Cat.No: T78923

Target: Epigenetic Reader Domain

Cat.No: T78916

Target: Sigma receptor

Cromolyn (sodium salt hydrate)

Cat.No: T38326

Target: Others

Cat.No: T83213

Target: Others

Ligustrazine HCl

Cat.No: T67212

Target: Others

Cat.No: T60289

Target: Others

δ14-Triamcinolone acetonide

Cat.No: T35461

Target: Others

Cat.No: T21916

Target: Others

Reduced Haloperidol

Cat.No: T37167

Target: Others

Leukotriene C4 methyl ester

Cat.No: T37620

Target: Others

Cat.No: T31657

Target: Others

Cat.No: T36851

Cat.No: T83731

Cat. No.	Product Name	Target	Signaling Pathways
T0690	Quinine 奎宁树	Potassium Channel; Platelet aggregation; Parasite	Membrane transporter/Ion channel; Microbiology/Virology; Others
	Quinine 是一种从金鸡纳树皮中提取的生物碱，用于预防和治疗疟疾。它也用于特发性肌肉痉挛，可抑制电压脉冲引起的 MT mSlo3 (KCa5.1) 通道 +100 mV 电流, 其IC50值为 169 μM，是一种钾离子通道抑制剂。
T0330	Diphenhydramine hydrochloride 盐酸苯海拉明,Diphenhydramine HCl,DPH	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Diphenhydramine hydrochloride (DPH) 是一种组胺 H1 拮抗剂，用作镇咳药和止吐药。它还用于治疗瘙痒和皮肤病、过敏反应、抗帕金森病、催眠药和普通感冒制剂的成分。
T0186	Docetaxel trihydrate RP-56976 (Trihydrate),RP56976 (NSC 628503) Trihydrate,多西他赛三水合物	Apoptosis; BCL; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Docetaxel trihydrate (RP-56976 Trihydrate) 是一种抗肿瘤试剂，抑制微管解聚的IC50值为 0.2 μM。它是紫杉醇的半合成类似物，能减弱 bcl-2 和 bcl-xL 基因表达的影响。它阻滞G2/M 细胞周期，导致细胞凋亡。
T21261	Phaseolin
	Phaseolin, a protein from red kidney bean (Phaseolus vulgaris L.), plays a pivotal role in hypersensitivity induction.
TN7449	8-Hydroxy-5,7-dimethoxyflavanone	Others	Others
	8-Hydroxy-5,7-dimethoxyflavanone (PDMF) is a phytochemical with tumor-preventive properties, promoting p53-driven G2/M cell cycle arrest and apoptosis. It is a potent anti-allergic agent for preventing IgE-driven hypersensitivity reactions and possesses anti-inflammatory activity.
T36845	Isogarcinol	Others	Others
	Isogarcinol is a natural polyisoprenylated benzophenone first isolated from plant species in the genus Garcinia. It has immunosuppressant actions, inhibiting the protein phosphatase calcineurin (IC50 = 36 μM) and suppressing the proliferation of T cells. Oral administration of isogarcinol in mice decreases delayed type hypersensitivity, prolongs graft survival in allogeneic skin transplants, suppresses inflammation in collagen-induced arthritis, and reduces clinical symptoms in experimental auto...
T83864	Plipastatin A1 SNA-60-367-3,Fengycin IX	Others	Others
	Plipastatin A1是一种在B. cereus中发现的脂肽类化合物，具有酶抑制活性和免疫抑制活性。它能抑制磷脂酶A2（PLA2）、PLC和PLD（IC50分别为2.9、1.3和1.4 µM）。Plipastatin A1（100 µg/ml）能抑制LPS诱导的B细胞爆发生成和Concanavalin A诱导的T细胞爆发生成。在体内，Plipastatin A1（0.1 mg/动物）能抑制小鼠的迟发型超敏反应。

天然产物

Cat.No: T0690

Synonym: 奎宁树

Target: Potassium Channel, Platelet aggregation, Parasite

Diphenhydramine hydrochloride

Cat.No: T0330

Synonym: 盐酸苯海拉明,Diphenhydramine HCl,DPH

Target: Histamine Receptor

Docetaxel trihydrate

Cat.No: T0186

Synonym: RP-56976 (Trihydrate),RP56976 (NSC 628503) Trihydrate,多西他赛三水合物

Target: Apoptosis, BCL, Microtubule Associated

Cat.No: T21261

8-Hydroxy-5,7-dimethoxyflavanone

Cat.No: TN7449

Target: Others

Cat.No: T36845

Target: Others

Cat.No: T83864

Synonym: SNA-60-367-3,Fengycin IX

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02499	Allergin-1 Protein, Mouse, Recombinant (His & Myc) Mca32,Gm885,Allergy inhibitory receptor 1,Mast cell immunogl...	Mouse	E. coli
	Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction. Allergin-1 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 20.1 kDa and the accession number is Q3TB92.
TMPH-01011	PRG2 Protein, Human, Recombinant (GST & His) Bone marrow proteoglycan,PRG2,Proteoglycan 2	Human	E. coli
	Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA. PRG2 Protein, Human, Recombinant (GST & His) is expressed in E. coli expression system with N-6xHis-GST tag. The predicted molecular weight is 41.2 kDa and the accession number is P13727.
TMPY-02544	FANCA Protein, Human, Recombinant (His) FA-H,FA1,FAA,FAH,FANCH,FACA,Fanconi anemia, complementation ...	Human	Baculovirus Insect Cells
	FANCA is one of the six known Fanconi anemia gene products (FANCA, FANCC, FANCD2, FANCE, FANCF, and FANCG proteins). Fanconi anemia (FA) is a genetic disorder predisposing to aplastic anemia and cancer characterized by hypersensitivity to DNA-damaging agents and oxidative stress. FANCA associates with the IκB kinase (IKK) signalsome via interaction with IKK2. Components of the FANCA complex undergo rapid, stimulus-dependent changes in phosphorylation, which are blocked by kinase-inactive IKK2.
TMPJ-00476	BMPG Protein, Human, Recombinant (His) Bone Marrow Proteoglycan,PRG2,Proteoglycan 2,Eosinophil Gran...	Human	HEK293 Cells
	Bone Marrow Proteoglycan (BMPG) is a secreted protein that contains one C-type lectin domain. BMPG is the predominant constituent of the crystalline core of the eosinophil granule. BMPG is highly expressed in placenta and pregnancy serum. BMPG may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin. BMPG induces non-cytolytic histamine release from human basophils. In addition, BMPG also participated in antiparasitic defense mechanisms and immune hypersensitivity re...
TMPH-02118	SCN1A Protein, Human, Recombinant (His) Sodium channel protein brain I subunit alpha,Sodium channel ...	Human	E. coli
	Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Plays a key role in brain, probably by regulating the moment when neurotransmitters are released in neurons. Involved in sensory perception of mechanical pain: activation in somatosensory neur...
TMPJ-00500	Kappa-Casein Protein, Human, Recombinant (His) CSNK,Kappa-Casein,κ-Casein,CSN10,CASK,CSN3	Human	HEK293 Cells
	Kappa-Casein (CSN3) is a secreted protein that belongs to the Kappa-Casein family. CSN3 exists in heteromultimers that are composed of alpha-s 1casein and kappa casein linked by disulfide bonds. CSN3 is involved in a number of important physiological processes. In the gut, CSN3 protein is split into an insoluble peptide (para kappa-casein) and a soluble hydrophilic glycopeptide (caseinomacropeptide). Caseinomacropeptide is responsible for increased efficiency of digestion, prevention of neonat...
TMPY-04945	Der p 2 Protein, Dermatophagoides pteronyssinus, Recombinant (His)	Dermatophagoides pteronyssinus	E. coli
	Hypersensitivity to house dust mite (Dermatophagoides sp.) allergens is one of the most common allergic reactions in the world. The house dust mite allergen, Der p 2, is a major allergen and 80–90% of patients who react to mite extract, react specifically to this protein or its homologues. Although it is well characterized in terms of allergenicity, there is still some ambiguity in terms of its biological function. Three-dimensional structural analysis of Der p 2 and its close homologues indicat...
TMPJ-01159	CD16/FCGR3 Protein, Mouse, Recombinant (His) IgG Fc receptor III,CD16,FcRIII,Low affinity immunoglobulin ...	Mouse	HEK293 Cells
	Low affinity immunoglobulin gamma Fc region receptor III (Fc gamma RIII/CD16) is a member of the Ig superfamily. Based on close relationships in their extracellular domains, the Fc gamma Rs have been divided into three classes composing of Fc gamma RI (CD64), Fc gamma RII (CD32), and Fc gamma RIII (CD16). Each group may be encoded by multiple genes and exist in different isoforms depending on species and cell type. Mouse CD16 is a type I transmembrane protein having two extracellular Ig-like dom...
TMPJ-00599	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (hFc & His) TIM3,Hepatitis A virus cellular receptor 2,KIM-3,T-cell memb...	Human	HEK293 Cells
	Hepatitis A virus cellular receptor 2（HAVCR2）is a single-pass type I membrane protein and it contains 1 Ig-like V-type (immunoglobulin-like) domain. The protein belongs to the immunoglobulin superfamily, and TIM family of proteins. The protein regulates macrophage activation. It inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. It may be also involved in T-cell homing and it is receptor for LGALS9. CD4 (MIM 186940)-positive T ...

重组蛋白

Allergin-1 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02499

Species: Mouse

Expression System: E. coli

PRG2 Protein, Human, Recombinant (GST & His)

Cat.No: TMPH-01011

Species: Human

Expression System: E. coli

FANCA Protein, Human, Recombinant (His)

Cat.No: TMPY-02544

Species: Human

Expression System: Baculovirus Insect Cells

BMPG Protein, Human, Recombinant (His)

Cat.No: TMPJ-00476

Species: Human

Expression System: HEK293 Cells

SCN1A Protein, Human, Recombinant (His)

Cat.No: TMPH-02118

Species: Human

Expression System: E. coli

Kappa-Casein Protein, Human, Recombinant (His)

Cat.No: TMPJ-00500

Species: Human

Expression System: HEK293 Cells

Der p 2 Protein, Dermatophagoides pteronyssinus, Recombinant (His)

Cat.No: TMPY-04945

Species: Dermatophagoides pteronyssinus

Expression System: E. coli

CD16/FCGR3 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01159

Species: Mouse

Expression System: HEK293 Cells

TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (hFc & His)

Cat.No: TMPJ-00599

Species: Human

Expression System: HEK293 Cells

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