|
TMPH-01081
|
CHMP7 Protein, Human, Recombinant (His)
Charged multivesicular body protein 7,Chromatin-mod...
|
Human
|
E. coli
|
|
ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway. CHMP7 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 56.9 kDa and the accession number is Q8WUX9. |
|
TMPH-00089
|
SPT16 Protein, Arabidopsis thaliana, Recombinant (His & SUMO)
Facilitates chromatin transcription complex subunit...
|
Arabidopsis thaliana
|
E. coli
|
|
SPT16 Protein, Arabidopsis thaliana, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 36.9 kDa and the accession number is O82491. |
|
TMPH-00886
|
ATF7IP2 Protein, Human, Recombinant (His)
MCAF2,ATF7-interacting protein 2,Activating transcription fa...
|
Human
|
E. coli
|
|
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) activity (Probable). AT... |
|
TMPH-02580
|
CHRAC1 Protein, Mouse, Recombinant (His & Myc)
CHRAC-1,NF-YC-like protein,Chrac1,YCL1,Chromatin ac...
|
Mouse
|
E. coli
|
|
Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex. CHRAC1 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 21.4 kDa and the accession number is Q9JKP8. |
|
TMPH-02159
|
SMARCC1 Protein, Human, Recombinant (His & SUMO)
SWI/SNF-related matrix-associated actin-dependent regulator ...
|
Human
|
E. coli
|
|
SMARCC1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 41.5 kDa and the accession number is Q92922. |
|
TMPH-02160
|
SMARCB1 Protein, Human, Recombinant (His)
BRG1-associated factor 47,SNF5 homolog,Integrase interactor ...
|
Human
|
E. coli
|
|
SMARCB1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 49.0 kDa and the accession number is Q12824. |
|
TMPH-01905
|
SMARCA2 Protein, Human, Recombinant (His)
Probable global transcription activator SNF2L2,SWI/SNF-relat...
|
Human
|
P. pastoris (Yeast)
|
|
SMARCA2 Protein, Human, Recombinant (His) is expressed in Yeast. |
|
TMPH-01906
|
SMARCA2 Protein, Human, Recombinant (His & SUMO)
BRG1-associated factor 190B,SNF2-alpha,SWI/SNF-related matri...
|
Human
|
E. coli
|
|
SMARCA2 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. |
|
TMPH-02217
|
SMARCA4 Protein, Human, Recombinant (His)
Transcription activator BRG1,Protein brahma homolog 1,SWI/SN...
|
Human
|
P. pastoris (Yeast)
|
|
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor compl... |
|
TMPH-00841
|
SMARCA4 Protein, Human, Recombinant (His)
ATP-dependent helicase SMARCA4,Mitotic growth and transcript...
|
Human
|
E. coli
|
|
SMARCA4 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 37.1 kDa and the accession number is P51532. |
|
TMPY-00117
|
FGF-16 Protein, Human, Cynomolgus, Recombinant
fibroblast growth factor 16
|
Human,Cynomolgus
|
Baculovirus Insect Cells
|
|
Fibroblast growth factor 16 (FGF16) is preferentially expressed in the heart after birth, suggesting its regulation is associated with tissue-specific chromatin remodeling and DNA-protein interactions. Mutation of the MEF2 site resulted in a blunting of FGF16 promoter activity in transfected neonatal rat cardiac myocytes, that chromatin remodeling and MEF2 binding in the FGF16 promoter contribute to expression in the postnatal heart. FGF16 involvement in the fine tuning of the human skeleton of ... |
|
TMPY-02580
|
Histone H1 Protein, Human, Recombinant (His)
HSP60,HSP65,CPN60,H1 histone family, member 0,H10,HLD4,HSPD1...
|
Human
|
E. coli
|
|
H1 histone family, member 0 (H1F0) is a member of the H1 histone family of nuclear proteins which are a component of chromatin in eukaryotic cells. It's involved in maintaining the structure of chromatin by packing the "beads on a string" sub-structure into a high order structure. The lysine-rich H1 histone family in mammals includes eleven members. In higher eukaryotes, all H1 variants have the same general structure, consisting of a central conserved globular domain and less conserved N-termin... |
|
TMPY-00005
|
FGF-8a Protein, Human, Recombinant
fibroblast growth factor 8 (androgen-induced),FGF-8,AIGF,NEW...
|
Human
|
E. coli
|
|
In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. Retinoic acid (RA) directly represses Fgf8 through a RARE-mediated mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of RA-FGF antagonism during progenitor cell differentiation. Fgf8 encodes a key signaling fac... |
|
TMPY-06986
|
FGF-8b Protein, Human, Recombinant
NEWENTRY,fibroblast growth factor 8 (androgen-induced),FGF-8...
|
Human
|
E. coli
|
|
In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. Retinoic acid (RA) directly represses Fgf8 through a RARE-mediated mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of RA-FGF antagonism during progenitor cell differentiation. Fgf8 encodes a key signaling fac... |
|
TMPY-02521
|
HIST3H2A Protein, Human, Recombinant
histone cluster 3, H2a,MGC3165
|
Human
|
E. coli
|
|
Histones are a complex family of highly conserved basic proteins responsible for packaging chromosomal DNA into nucleosomes. There are subtype diversities: H1, H2A, H2B, and H3 or H4. It has become more and more evident that histone modifications are key players in the regulation of chromatin states and dynamics as well as in gene expression. Therefore, histone modifications and the enzymatic machinery that set them are crucial regulators that can control cellular proliferation, differentiation,... |
|
TMPY-03650
|
BirA Protein, E. coli, Recombinant (His & MBP)
BirA,dhbB,bioR
|
E. coli
|
E. coli
|
|
The enzyme BirA is a key reagent because of its ability to biotinylate proteins at a specific residue in a recognition sequence. This enzyme is used to biotinylate the C termini of membrane proteins, allowing these proteins to be tetramerized by binding to streptavidin. Because of the specificity of the biotinylation at the C terminus, the orientation of the membrane proteins on the streptavidin is equivalent to that of the native protein on the cell surface. These tetrameric proteins can be use... |
|
TMPJ-01399
|
ASF1A Protein, Human, Recombinant (His, T7)
CIA,Anti-Silencing Function Protein 1 Homolog A,ASF1A,Histon...
|
Human
|
E. coli
|
|
Human Histone Chaperone ASF1A (ASF1A) belongs to the H3/H4 family of histone chaperone proteins. ASF1A is ubiquitously expressed in many cells and tissues, interacting with histones H3 and H4. ASF1A cooperates with Chromatin Assembly Factor 1 to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. In addition, ASF1A is necessary for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associat... |
|
TMPH-02849
|
DEK Protein, Mouse, Recombinant (His)
|
Mouse
|
Baculovirus Insect Cells
|
|
Involved in chromatin organization. |
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TMPH-01236
|
DFFB Protein, Human, Recombinant (His)
DNA fragmentation factor 40 kDa subunit,Caspase-activated DN...
|
Human
|
E. coli
|
|
Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology. |
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TMPJ-00694
|
BRD4 Protein, Human, Recombinant (His & Flag)
MCAP,HUNK1,HUNKI,bromodomain-containing protein 4
|
Human
|
E. coli
|
|
Bromodomain-containing protein 4 (BRD4) is a member of the BET class chromatin reader proteins that bind acetylated histones and play a key role in transcriptional regulation and transmission of epigenetic memory. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure. BRD bromodomains serve as recognition motifs for ... |
|
TMPH-01800
|
Nucleolin Protein, Human, Recombinant (His)
NCL,Protein C23,Nucleolin
|
Human
|
P. pastoris (Yeast)
|
|
Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Nucleolin Protein, ... |
|
TMPH-01091
|
CHD1L Protein, Human, Recombinant (His & SUMO)
Amplified in liver cancer protein 1,CHD1L,ALC1,Chromodomain-...
|
Human
|
E. coli
|
|
DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding. CHD1L Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 37.3 kDa an... |
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TMPH-01477
|
Histone H1.3 Protein, Human, Recombinant (His & MBP)
Histone H1s-2,H1-3,Histone H1.3,Histone H1c
|
Human
|
E. coli
|
|
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. HIST1H1D Protein, Human, Recombinant (His & MBP) is expressed in E. coli expression system with N-MBP and C-6xHis tag. The predicted molecula... |
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TMPH-01090
|
CBX8 Protein, Human, Recombinant (His)
Polycomb 3 homolog,hPc3,Pc3,Rectachrome 1,CBX8,Chromobox pro...
|
Human
|
E. coli
|
|
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. CBX8 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. Th... |
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TMPH-00770
|
2S albumin Protein, Glycine max, Recombinant (His)
2S albumin,Napin-type 2S albumin 3,GM2S-1,2S seed storage al...
|
Glycine max
|
P. pastoris (Yeast)
|
|
This is a 2S seed storage protein.; binds to mammalian chromatin, preventing the normal formation of the kinetochore complex in the centromere and leading to the disruption of mitosis. |
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TMPJ-00918
|
HMGB2 Protein, Human, Recombinant (His)
High Mobility Group Protein B2,HMG2,High Mobility Group Prot...
|
Human
|
HEK293 Cells
|
|
High Mobility Group Protein B2 (HMGB2) belongs to the non-histone chromosomal high-mobility group protein family. Members of this family are chromatin-associated and widely spread in the nucleus of higher eukaryotic cells. HMGB2 contains 2 HMG box DNA-binding domains. It is associated with chromatin and has the ability to bend DNA, preferentially single-stranded DNA. It is shown that HMGB2 is able to efficiently bend DNA and form DNA circles. In addition, HMGB2 is involved in the final ligation ... |
|
TMPH-02227
|
ERG Protein, Human, Recombinant (His)
Transcriptional regulator ERG,Transforming protein ERG,ERG
|
Human
|
P. pastoris (Yeast)
|
|
Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure. ERG Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 56.6 kDa and the accession number is P11308. |
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TMPJ-00986
|
CTCF Protein, Human, Recombinant
Transcriptional Repressor CTCF,CCCTC-Binding Factor,CTCFL Pa...
|
Human
|
E. coli
|
|
Transcriptional Repressor CTCF (CTCF) belongs to the CTCF Zinc-Finger Protein family. CTCF contains twelve C2H2-type zinc fingers and interacts with CHD8. CTCF is widely expressed in many tissues, and it is absent in primary spermatocytes. CTCF is involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. CTCF plays an essential role in oocyte and preimplantation embryo development by activating or rep... |
|
TMPH-00604
|
CDTA Protein, E. coli, Recombinant (His)
Cytolethal distending toxin subunit A,CDTA,CDT A
|
E. coli
|
E. coli
|
|
CDTs are cytotoxins which induce host cell distension, growth arrest in G2/M phase, nucleus swelling, and chromatin fragmentation in HeLa cells. CdtA, along with CdtC, probably forms a heterodimeric subunit required for the delivery of CdtB. |
|
TMPY-01332
|
HIST1H3A Protein, Human, Mouse, Recombinant
Histone H3.1,histone cluster 1, H3a,Histone H3
|
Human,Mouse
|
E. coli
|
|
Histone H3.1, also known as HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J, is a member of the histone H3 family which is a core component of nucleosome. It is expressed during the S phase, then expression strongly decreases as cell division slows down during the process of differentiation. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machinery which requires DNA as a template. Histones thereby pla... |
|
TMPH-01213
|
DNASE1L3 Protein, Human, Recombinant (His)
DNase I homolog protein DHP2,DNAS1L3,DNase I-like 3,Deoxyrib...
|
Human
|
Baculovirus Insect Cells
|
|
Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA. Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis. The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells. Is active on chromatin in apoptotic cell-derived membrane-coated mic... |
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TMPY-03498
|
ING4 Protein, Human, Recombinant (His)
inhibitor of growth family, member 4,p29ING4,my036
|
Human
|
E. coli
|
|
ING4 is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. ING4 contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. ING4 protein can bind TP53 and EP3/p3, a component of the histone acetyltransferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. ING4 is a component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activi... |
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TMPH-01214
|
DNASE1L3 Protein, Human, Recombinant
DHP2,Deoxyribonuclease I-like 3,Deoxyribonuclease gamma,DNas...
|
Human
|
E. coli
|
|
Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA. Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis. The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells. Is active on chromatin in apoptotic cell-derived membrane-coated mic... |
|
TMPH-01212
|
DNASE1L3 Protein, Human, Recombinant (His & Myc)
LSD,Liver and spleen DNase,Deoxyribonuclease I-like 3,DNAS1L...
|
Human
|
E. coli
|
|
Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends. Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA. Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis. The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells. Is active on chromatin in apoptotic cell-derived membrane-coated mic... |
|
TMPJ-00675
|
ZNHIT1 Protein, Human, Recombinant (His)
ZNFN4A1,CGBP1,inc finger HIT domain-containing protein 1,cyc...
|
Human
|
E. coli
|
|
ZNHIT1 belongs to the ZNHIT1 family and contains one HIT-type zinc finger. It can be phosphorylated on Thr by MAPK11 or MAPK14. ZNHIT1 is a component of the chromatin-remodeling SRCAP complex, which is composed of at least SRCAP, DMAP, RUVBL1, RUVBL2, ACTL6A, YEATS4, ACTR6 and ZNHIT1. ZNHIT1 may play a role in p53-mediated apoptosis induction. |
|
TMPH-00769
|
2S albumin Protein, Glycine max, Recombinant (His & SUMO)
2S seed storage albumin protein,Napin-type 2S albumin 3,2S a...
|
Glycine max
|
E. coli
|
|
This is a 2S seed storage protein.; binds to mammalian chromatin, preventing the normal formation of the kinetochore complex in the centromere and leading to the disruption of mitosis. 2S albumin Protein, Glycine max, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 32.2 kDa and the accession number is P19594. |
|
TMPH-01776
|
HMGN2 Protein, Human, Recombinant (GST)
Non-histone chromosomal protein HMG-17,HMGN2,High mobility g...
|
Human
|
E. coli
|
|
Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. HMGN2 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 36.4 kDa and the accession number is P05204. |
|
TMPH-01526
|
KMT2E Protein, Human, Recombinant (His & Myc)
Inactive histone-lysine N-methyltransferase 2E,Myeloid/lymph...
|
Human
|
E. coli
|
|
Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Also acts as an important cell cycle regulator, participating in cell cycle r... |
|
TMPY-04420
|
TLK1 Protein, Human, Recombinant (His & GST)
KIAA0137,PKU-beta,tousled like kinase 1,PKU-β
|
Human
|
Baculovirus Insect Cells
|
|
Tousled-like kinase 1 (or protein kinase ubiquitous, PKU-beta/TLK1) is a serine/threonine protein kinase that is implicated in chromatin remodeling, DNA replication and mitosis. TLK1 has a function important for proper chromosome segregation and maintenance of diploid cells at mitosis in mammalian cells that could be mediated by reduced phosphorylation of histone H3 and condensation of chromosomes, although other explanations to the phenotype are possible. |
|
TMPH-00605
|
CDTB Protein, E. coli, Recombinant (His & Myc & SUMO)
CDTB,Cytolethal distending toxin subunit B,Deoxyribonuclease...
|
E. coli
|
E. coli
|
|
Part of the tripartite complex that is required for the CDT activity. CdtB exhibits a DNA-nicking endonuclease activity, and very probably causes DNA damage in intoxicated cells. This damage induces G2/M cell cycle arrest, chromatin fragmentation, cell distention and nucleus enlargement. CDTB Protein, E. coli, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 47.4 kDa and the accession number is Q46669. |
|
TMPH-01088
|
CBX5 Protein, Human, Recombinant (His & Myc)
HP1 alpha,CBX5,Heterochromatin protein 1 homolog al...
|
Human
|
E. coli
|
|
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. CBX5 Protein... |
|
TMPJ-00483
|
DFF45 Protein, Human, Recombinant (His)
DNA Fragmentation Factor Subunit Alpha,DFF45,H13,ICAD,DFFA,D...
|
Human
|
E. coli
|
|
DNA Fragmentation Factor Subunit Alpha (DFFA). DFFA exists as a heterodimer (DFF) with DFFB. DFF is activated once DFFA is cleaved by Caspase-3. The cleaved fragments of DFFA detach from DFFB (the active component of DFF), which in turn triggers DNA fragmentation as well as chromatin condensation during apoptosis. A reduced level of DFFA detected in ovarian endometriosis may be a part of an apoptosis-resistant mechanism enhancing the disease progression. |
|
TMPH-01677
|
MBD2 Protein, Human, Recombinant (His & KSI)
Methyl-CpG-binding domain protein 2,Methyl-CpG-binding prote...
|
Human
|
E. coli
|
|
Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters. |
|
TMPH-02711
|
H2B type 1-M Protein, Mouse, Recombinant (His)
Histone H2B type 1-M,H2bc14,H2B 291B
|
Mouse
|
E. coli
|
|
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. HIST1H2BM Protein, Mouse, Recombinant (His) is expressed in E... |
|
TMPJ-00998
|
MECP2 Protein, Human, Recombinant (His)
Methyl-CpG-binding protein 2,MeCp-2 protein,MECP2
|
Human
|
HEK293 Cells
|
|
The MeCP2 helps regulate gene activity (expression) by modifying chromatin, the complex of DNA and protein that packages DNA into chromosomes. The MeCP2 protein is present in cells throughout the body, although it is particularly abundant in brain cells.In the brain, the MeCP2 protein likely plays a role in maintaining connections (synapses) between neurons, where cell-to-cell communication occurs. The alternative splicing of proteins is critical for normal communication between neurons and may ... |
|
TMPH-03193
|
Alba Protein, Pyrococcus furiosus, Recombinant (His & SUMO)
DNA/RNA-binding protein Alba
|
Pyrococcus furiosus
|
E. coli
|
|
Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes. Alba Protein, Pyrococcus furiosus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molec... |
|
TMPJ-01040
|
MAX Protein, Human, Recombinant (His)
Protein Max,MAX,bHLHd4,Myc-Associated Factor X,Class D Basic...
|
Human
|
E. coli
|
|
Myc-Associated Factor X (MAX) is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It contains 1 basic helix-loop-helix (bHLH) domain. It is found in the brain, heart, and lung at high levels while lower levels are seen in the liver, kidney, and skeletal muscle. MAX forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC-MAX complex is a transcriptional activator, whereas the MA... |
|
TMPH-02205
|
Titin Protein, Human, Recombinant (His)
Connectin,TTN,Rhabdomyosarcoma antigen MU-RMS-40.14,Titin
|
Human
|
E. coli
|
|
Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to ch... |
|
TMPY-03596
|
JTB Protein, Human, Recombinant (mFc)
PAR,hJT,jumping translocation breakpoint,JTB,HSPC222,HJTB
|
Human
|
HEK293 Cells
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Jumping translocation breakpoint, also known as JTB, is a member of the JTB family. Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomal segments jumping to various telomeres. JTB is expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts. It is required for normal cytokinesis during mitosis. JTB plays a role in the regulation of cell proliferation. It may be a component of the chromosomal... |
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TMPH-02221
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TRIM24 Protein, Human, Recombinant (His & SUMO)
Transcription intermediary factor 1-alpha,E3 ubiquitin-prote...
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Human
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E. coli
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Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apopt... |
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