PTEN

bpV(phen) is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor (IC50s: 343 nM, 920 nM, and 38 nM for PTP-β, PTP-1B, and PTEN).

Cucurbitacin B (Cuc B) 是一具有抗癌活性的天然产物。

Oroxin B 是从传统中草药木蝴蝶中分离出来的黄酮类天然产物，在恶性淋巴瘤细胞中诱导肿瘤抑制性 ER 应激。它通过上调 PTEN，下调 COX-2，VEGF，PI3K 和 p-AKT，对肝癌细胞具有明显的抑制作用，诱导细胞早期凋亡。

SF1670 (PTPase CD45 Inhibitor) 是一种特异性 PTEN 抑制剂，IC50 为 2 μM。

Ginkgolic acid C17:1 是分离自银杏叶中，通过诱导PTEN 和SHP-1酪氨酸磷酸酶抑制组成型和诱导型 STAT3 活化。它具有抗癌活性。

VO-Ohpic trihydrate (VO-Ohpic) 是一种有效的磷酸酶和张力蛋白同源物（PTEN）抑制剂，IC50 为 35 nM。

BpV(HOpic) (bpV (HOpic)) 是 PTEN 选择性抑制剂，IC50=14 nM。BpV(HOpic) 具有神经保护作用。

Afzelin (Kaempferol-3-O-rhamnoside) 具有多种细胞活性，例如 DNA 保护、抗菌、抗氧化和抗炎以及 UV 吸收活性，并且可以通过 UV 吸收和细胞活性的组合保护人体皮肤免受 UVB 引起的损伤。 Afzelin 减轻线粒体损伤，增强线粒体生物合成并降低线粒体自噬相关蛋白、parkin 和 putative kinase 1 的水平。

Salidroside 是一种从红景天中分离出来的具有生物活性的酚苷化合物，是一种脯氨酰内肽酶抑制剂。Salidroside能通过激活 mTOR 信号缓解肿瘤恶病质小鼠模型中的恶病质症状，还能通过增强 PINK1/Parkin 介导的线粒体自噬来保护多巴胺能神经元。Salidroside也可以通过调节CDK4-cyclin D1通路阻滞G1期和/或调节Cdc2-cyclin B1通路阻滞G2期阻滞来抑制癌细胞的生长。

Matrine (Vegard) 是一种从槐属植物中分离出来的生物碱，可作为一种κ阿片受体激动剂，有抗肿瘤活性。

CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) 是一种氧化磷酸化 (OXPHOS) 抑制剂，线粒体质子载体解偶联剂。CCCP 抑制 STING 及其下游信号分子 TBK1 和 IRF3 的激活。

MitoBloCK-11 (MB-11) 是线粒体蛋白输入的小分子抑制剂，可能通过转运蛋白 Seo1 起作用，但不通过 Tom70 或 Tom20；抑制含有疏水片段的前体蛋白，以特定方式在缺乏尿嘧啶的培养基中促进生长，并影响斑马鱼的发育。

CIB-L43是高亲和力和可口服的 TRBP 抑制剂 (KD = 4.78 nM)，能够有效抑制致癌miR-21的生物合成，增加PTEN和Smad7的表达，并阻断AKT和TGF-β信号通路，从而抑制肝细胞癌（HCC）细胞的增殖和迁移。

BpV(phen) trihydrate是一种胰岛素模拟物和一种有效的PTP和PTEN抑制剂，对 PTEN/PTP-β/PTP-1B的IC50=38/343/920 nM，对利什曼原虫具有抑制活性，能够诱导细胞凋亡和促炎因子分泌，激活Th1型途径，具有抗血管生成和抗肿瘤活性。

VO-OHPic is a reversible, noncompetitive, and selective inhibitor of PTEN with an IC50 of 46 nM. It effectively attenuates apoptosis, adverse cardiac remodeling, and the presence of pro-inflammatory M1 macrophages in models of doxorubicin-induced cardiomyopathy. Additionally, VO-OHPic inhibits autophagy [1] [2] [3].

Cefminox (Sodium) is a new cephamycin antibiotic possessing a D-amino acid moiety derived from D-cysteine at the C-7B side chain. Cefminox is active against a wide range of bacteria, especially Gram-negative and anaerobic bacteria. Cefminox shows excellent in vivo efficacy (ED50) which is higher than would be expected from its in vitro activity (MIC). Moreover, cefminox possesses more potent activity in suppression of bacterial regrowth than other cephems[1]. Cefminox (Sodium) was the most active beta-lactam, with an MIC at which 50% of isolates are inhibited (MIC50) of 1.0 microg/ml and an MIC90 of 16.0 microg/ml. Cefminox was especially active against Bacteroides fragilis (MIC90, 2.0 microg/ml), Bacteroides thetaiotaomicron (MIC90, 4.0 microg/ml), fusobacteria (MIC90, 1.0 microg/ml), peptostreptococci (MIC90, 2.0 microg/ml), and clostridia, including Clostridium difficile (MIC90, 2.0 microg/ml)[2]. The use of a single preoperative dose of cefminox was similar in efficacy to 3 doses of cefoxitin administered every 4 hours, and that the serum and tissue concentrations attained provide adequate antibiotic coverage[3]. Moreover, cefminox as a dual agonist of IP (Prostacyclin receptor) and PPARγ (peroxisome proliferator-activated receptor-gamma) that significantly inhibits PASMC proliferation by up-regulation of PTEN (phosphatase and tensin homolog) and cAMP ( cyclic adenosine monophosphate), suggesting that it has potential for treatment of PAH(pulmonary arterial hypertension)[4].

MTK458 (EP-0035985) 是一种具有口服活性和脑渗透性的 PINK1 激活剂，在PFF 接种模型中促进 α-突触核蛋白病理学的清除并降低 pUb。MTK458 通过刺激 PINK1/TOM 复合物的二聚化和稳定来诱导病理学的α-突触核蛋白清除。MTK458 可用于帕金森病的研究。

SQLE-IN-1 是一种角鲨烯环氧化酶 (SQLE) 抑制剂，具有抗肿瘤活性，可抑制肝癌细胞系 Huh7 的增殖和迁移能力，抑制细胞胆固醇的生成，增加抑癌基因PTEN的表达，抑制PI3K和AKT的蛋白表达。

Valinomycin (NSC-122023) 是钾离子选择性运输载体，是一种环状缩酚肽类抗生素。它通过影响生物膜抑制淋巴细胞的扩增，能诱导 CHO 细胞凋亡，也可诱导 PINK1 激活，促进 Parkin 在 Ser65 位点磷酸化。

Kinetin triphosphate tetrasodium(KTP tetrasodium)是Kinetin triphosphate的四钠盐形式。Kinetin triphosphate是一种ATP类似物，能够增强帕金森病相关突变体线粒体激酶PINK1(G309D) 和 PINK1(WT)的活性，对神经退行性疾病具有治疗潜力。

T0467 is a chemical compound that activates the translocation of parkin to the mitochondria in a PINK1-dependent manner in vitro. However, T0467 does not induce the accumulation of PINK1 in the mitochondria of dopaminergic neurons. As a result, T0467 shows promise as a potential compound for activating the PINK1-Parkin signaling pathway and can be utilized in research related to Parkinson's disease and related disorders.

FT3967385 is a newly developed compound that functions as a USP30 inhibitor, emulating the genetic deficiency of USP30. This inhibition serves as a catalyst for the amplification of mitochondrial ubiquitylation through the PINK1-PARKIN pathway.

Sophocarpine 是一种从传统草药苦参中提取的重要生物碱。苦参具有抗病毒、抗肿瘤和抗炎等多种药理作用。它通过多种机制显著抑制癌细胞的生长，具有抗肿瘤活性。

FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone) 是一种氧化磷酸化 (OXPHOS) 抑制剂，线粒体质子载体解偶联剂。FCCP 常被用作细胞凋亡诱导剂。