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Targets Recommended: P2X Receptor

61

抑制剂 & 化合物

2

天然产物

5

化合物库

18

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name
L9410	共价抑制剂库		1920 compounds
	1920 种小分子的独特集合，包含已发现的共价抑制剂以及包含某些共价反应基团常见弹头的分子，如氯乙酰基，2-氯丙酰基，丙烯酰基，1-丙-2-炔基，1-丁-2-炔基，酮羰基，二硫键等，可以用于共价抑制剂药物研发；
L2520	糖代谢化合物库		702 compounds
	702 种糖代谢相关的化合物，可用于高通量和高内涵筛选；
L9420	外泌体相关化合物库		76 compounds
	76 种外泌体相关的化合物，可以用于高通量和高内涵筛选；
L6210	藏药化合物库		747 compounds
	747 种藏药来源的天然产物分子集合，可以用于高通量和高内涵筛选；
L6810	中药单体化合物库		2755 compounds
	2755 种中药来源的单体化合物，是药物开发、药理研究等领域的有力工具；

化合物库

共价抑制剂库

Cat.No: L9410

Compounds: 1920

糖代谢化合物库

Cat.No: L2520

Compounds: 702

外泌体相关化合物库

Cat.No: L9420

Compounds: 76

藏药化合物库

Cat.No: L6210

Compounds: 747

中药单体化合物库

Cat.No: L6810

Compounds: 2755

Cat. No.	Product Name	Target	Signaling Pathways
T10466	BAY-1797	P2X Receptor	Membrane transporter/Ion channel; Neuroscience
	BAY-1797 是具有口服活性的选择性P2X4高效拮抗剂，对人 P2X4 的IC50为 211 nM，具有抗伤害和抗炎作用。
T2067	NS11394 NS 11394	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	NS11394 是可口服GABAA 的阳性变构调节剂 (PAM)，Ki 值为 0.5 nM。它对GABAA 的选择性依次为 α5、α3、α2 和α1 受体，具有抗炎和抗焦虑活性。
TQ0039	(±)-Zanubrutinib (±)-BGB-3111	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	(±)-Zanubrutinib ((±)-BGB-3111) 是一种有效的口服Bruton’s 酪氨酸激酶(Btk)抑制剂，具有优越的口服生物利用度，可实现更高的暴露量和更完整的靶点抑制。
T70388	(S)-Enitociclib VIP152	CDK	Cell Cycle/Checkpoint
	(S)-Enitociclib (VIP152) 是一种选择性 CDK9 抑制剂，通过抑制 RNA 聚合酶 II 介导的转录来诱导 MYC+ 淋巴瘤的完全消退，抑制抗凋亡和促生存蛋白的转录。
T1486	Oseltamivir phosphate GS 4104,磷酸奥司他韦	Influenza Virus	Microbiology/Virology
	Oseltamivir phosphate (GS 4104) 是一种神经氨酸酶抑制剂，可研究流感。
T39584	MI-3454	Histone Methyltransferase	Chromatin/Epigenetic
	MI-3454 是一种具有口服活性，选择性和高效性的 Menin-MLL1 相互作用抑制剂，可抑制具有 MLL1 易位或 NPM1 突变的急性白血病细胞增殖并诱导分化。MI-3454 通过下调参与白血病发生的关键基因，诱导MLL1重排或NPM1突变白血病小鼠模型中白血病的完全缓解或消退。
T22986	MK 1903	GPR	Endocrinology/Hormones; GPCR/G Protein
	MK 1903 是一种有效的、具有选择性的羟基羧酸受体2 (HCA2) 的完全激动剂。HCA2也叫做G 蛋白偶联受体109A(GPR109A) 。MK 1903在使用表达人受体(ECso-12.9 nM)的 CHO 细胞进行的均匀时间分辨荧光(htf)测定中，它减少了福斯克林诱导的 cAMP 的产生。
T9808	Tetradecylthioacetic acid	PPAR	DNA Damage/DNA Repair; Metabolism
	Tetradecylthioacetic acid 是一种合成脂肪酸，在 β 位具有硫取代。这种修饰使 TTA 无法进行完全的 β-氧化并增加其生物活性，包括激活过氧化物酶体增殖物激活受体 (PPAR)，优先选择 PPARα。
T6075	Epothilone B 帕妥匹隆,Patupilone,EPO 906	Apoptosis; Microtubule Associated; Antibiotic; Antifungal	Apoptosis; Cytoskeletal Signaling; Microbiology/Virology
	Epothilone B (EPO 906) 是微管稳定剂，Ki 为0.71 μM。它与αβ-微管蛋白异二聚体亚基结合，使αβ-微管蛋白解离减少。
T9542	NS3861	AChR	Neuroscience
	NS3861 是烟碱型乙酰胆碱受体的激动剂，对α3β4 nAChR 具有高亲和力。能够分别与α3β4 (Ki:0.62 nM)、α3β2 (Ki:25 nM)、α4β4 (Ki:7.8 nM)、α4β2 (Ki:55 nM) 结合。
T21543	AP 18	TRP/TRPV Channel	Membrane transporter/Ion channel
	AP-18 是选择性的 TRPA1 抑制剂。AP-18 可以抑制 50 μM 肉桂醛诱导的 TRPA1 激活，在小鼠和人中的 IC50 分别为 4.5 μM 和 3.1 μM。AP-18 可以逆转 CFA 诱导的小鼠机械性痛觉过敏。AP-18 可以浓度依赖的方式减弱 30 μM AITC 诱导的 Yo-Pro 摄取(IC50= 10.3 μM)。
T36466	Chlorin E6 Ce6,Chlorin e6,CE6	Parasite	Microbiology/Virology
	Chlorin E6 (CE6) 是一种第二代光敏剂，在与辐照结合使用时具有抗肿瘤活性。在植入性纤维肉瘤的小鼠模型中，Chlorin E6（2.5-10 毫克/千克，静脉注射，50-200 焦耳/平方厘米的辐照）在不同程度的辐照后会导致肿瘤完全消失。在一项针对支气管源性早期浅表鳞状细胞癌患者的 I 期临床研究中，对包括 Chlorin E6 在内的制剂进行了测试，结果良好（40 毫克/平方米，静脉注射，100 焦耳/平方厘米的激光辐照）。在一项针对早期肺癌患者的二期临床试验中，同样的给药模式使 82.9% 的患者获得了完全应答。Chlorin E6 已被研究为一种纳米技术给药工具。
T69989	(S)-Pomalidomide	Others	Others
	(S)-Pomalidomide is an inhibitor of angiogenesis and growth of B-cell neoplasias, which induces complete regressions of Burkitt's lymphoma cell tumors.
T39938	M-1211	Others	Others
	M 1121 is a covalent and orally active inhibitor of the menin-MLL interaction capable of achieving complete and persistent tumor regression.
T70681	G-4120	Others	Others
	G-4120 is a biochemical that has been shown to have a dose-dependent complete inhibition of arterial and venous thrombosis.
T15167	Draflazine R-75231	Others	Others
	Draflazine is an ENT1 inhibitor. It completely reverses the hypersensitivity in the complete Freund’s adjuvant (CFA) model of mechanical hyperalgesia. Draflazine also completely reverses the hypersensitivity of the carrageenan inflammation model of therma
T62266	PPARα agonist 1	Others	Others
	PPARα agonist 1 是一种完整的、有效的 PPARα激动剂。
T61305	LasR-IN-3	Others	Others
	LasR-IN-3, a chemical compound, acts as an inhibitor of LasR in Pseudomonas aeruginosa. It induces structural instability in LasR and causes complete dissociation of its functioning dimeric form [1].
T35480	dBRD9-A dBRD9-A	Others	Others
	Potent BRD9 degrader. Selectively binds BRD9 and elicits near complete degradation of BRD9 at nanomolar concentrations. Inhibits growth of synovial sarcoma cells in vitro and tumor progression in a synovial sarcoma xenograft mouse model.
T76572	Acetyl neurotensin (8-13)
	Acetyl neurotensin (8-13) 是神经降压素类似物，具有完全结合和药理活性。
T40409	Tau Peptide (275-305) (Repeat 2 domain)
	Tau Peptide (275-305), also known as the R2 domain fragment, represents the second repeat unit of the microtubule-binding domain of the Alzheimer's tau peptide. Tau Peptide (275-305) is considered crucial in determining the biochemical characteristics of the complete tau protein.
T40223	EEDi-5273	Others	Others
	EEDi-5273 is a highly potent and orally efficacious inhibitor of EED, with an approximate IC50 value of 0.2 nM. This compound exhibits exceptional activity, capable of achieving complete and persistent regression of tumors.
T80136	Val9-Oxytocin	Vasopressin Receptor	GPCR/G Protein
	Val9-Oxytocin为完全抗拮抗加压素(1a)受体的化合物，其结构上是Oxytocin的衍生物，特点在于Gly9位点被Val9取代。
T81352	pTH (2-38) (human)
	pTH (2-38) (human) 促进骨骼合成代谢，并能增加血清中INS-PTH（完整N末端特异性PTH）的水平。
T36946	PW0464 PW0464	Others	Others
	PW0464, a nanomolar potent complete G protein biased ligand, is a noncatechol D1R agonist, with an EC50 of 5.8 nM (Gs-cAMP)[1]. PW0464 (compound 24) is found to elicit complete G protein bias, showing no activity for D1R-mediated β-arrestin recruitment[1].PW0464 (compound 24), the non-catechol agonist, forms bonds with S1985.42 and S2025.46 via its fluorine atom[2]. [1]. Pingyuan Wang, et al. Synthesis and Pharmacological Evaluation of Noncatechol G Protein Biased and Unbiased Dopamine D1 Recept...
T35479	CRBN-6-5-5-VHL	PROTACs	PROTAC
	Potent and selective cereblon degrader (DC50 = 1.5 nM). Induces complete degradation of cereblon in MM1S cells. Comprises a cereblon E3 ligase ligand joined by a linker to a ligand for the E3 ligase VHL. Cell-permeable. Steinebach et al (2019) PROTAC-mediated crosstalk between E3 ligases. Chem.Commun.(Camb) 55 1821 PMID:30672516
T63328	AMXI-5001 hydrochloride	Others	Others
	AMXI-5001 hydrochloride 是口服具有活力的、有效的 parp1/2 和微管聚合抑制剂，且IC50 值明显低于现有的临床 PARP1/2 抑制剂。MXI-5001 hydrochloride 对多种人类癌细胞表现出选择性抗肿瘤细胞毒性，能够诱导已建立的肿瘤，包括较大的肿瘤完全消退。
T11314	Fosmanogepix APX001,E1211	Others	Others
	Fosmanogepix (APX001) is a first-in-class, orally available broad-spectrum antifungal agent. It acts as an N-phosphonooxymethyl prodrug that undergoes rapid and complete metabolism by systemic alkaline phosphatases. This metabolism leads to the formation of the active moiety, APX001A. Fosmanogepix (APX001), with its ability to target the highly conserved Gwt1 fungal enzyme, holds great potential for the development of treatments against invasive fungal infections.
T72284	Glucokinase activator 3	Others	Others
	Glucokinase activator3 是Glucokinase (GK) 的一种高效全效激活剂，AC50 值为 38 nM，具有研究 2 型糖尿病潜力。
T78672	I-287	Others	Others
	I-287为一种口服活性PAR2选择性抑制剂，能对Gαq和Gα12/13的活性以及其下游效应物施加负异构调控。该化合物能够减轻Complete Freund's adjuvant引发的小鼠炎症，适用于免疫炎症研究。
T71023	MI-888 free base	Others	Others
	MI-888 is a potent MDM2 inhibitor (Ki = 0.44 nM) with a superior pharmacokinetic profile and enhanced in vivo efficacy. MI-888 is capable of achieving rapid, complete, and durable tumor regression in two types of xenograft models of human cancer with oral administration and represents the most potent and efficacious MDM2 inhibitor reported to date.
T60637	PARP1-IN-11	Others	Others
	PARP1-IN-11 (compound 49) 是一种有效的 PARP1抑制剂，其 IC50值为 0.082 μM，可完全抑制 PARP1，并显著抑制 PARP3、TNKS1 和 TNKS2。
T70335	Cangrelor free acid	Others	Others
	Cangrelor is a P2Y12 inhibitor, and was approved in June 2015 as an antiplatelet drug for intravenous application. Cangrelor is a high-affinity, reversible inhibitor of P2Y12 receptors that causes almost complete inhibition of ADP-induced platelet aggregate. It is a modified ATP derivative stable to enzymatic degradation. It does not require metabolic conversion to an active metabolite. This allows cangrelor’s immediate effect after infusion, and the therapeutic effects can be maintained with...
T76549	TAT-NSF700scr
	TAT-NSF700scr拥有完整的TAT结构域和甘氨酸连接肽，后接随机排列的NSF氨基酸序列，该化合物作为非抑制SNARE介导的胞吐作用的对照肽而被使用。
T75406	Endoglycoceramidase II (EGCase II)	Others	Others
	Endoglycoceramidase II (EGCase II) 是一种能从糖鞘脂的神经酰胺部分释放完整聚糖的内切-β-葡萄糖苷酶。该酶专门催化多种糖鞘脂中寡糖与神经酰胺之间的 β-糖苷键的水解反应。
T76001	Apraglutide TFA
	Apraglutide TFA (FE 203799 TFA) 是一种合成的、含33个氨基酸的肽类药物，为长效GLP-2类似物。它能在全回肠切除后导致的新生短肠综合征小猪中增强适应性和线性肠生长。
T41164	FC 11	PROTACs	PROTAC
	FC 11 is a highly potent focal adhesion Ki nase (FAK) PROTAC®Degrader (DC50 values are 40 to 370 pM depending on cell line), which is composed of the FAK inhibitor PF 562217 joined by a linker to the cereblon-binding ligand Pomalidomide. The effects of FC 11 are reversible upon compound wash out. FC 11 also degrades autophosphorylated FAK (pFAKtyr397), displaying near complete degradation after 3 hours at 100 nM in TM3 cells.
T76513	2F5 epitope
	2F5 epitope 是肽 gp41 (659-671) 片段，包含能够中和广谱初级HIV-1分离株的三种已知抗体之一的完整表位，并且是连续表位。2F5 epitope 被广泛中和抗体 2F5 识别。
T34278	Redaporfin F 2BMet,F2BMet,F-2BMet,LUZ11,LUZ 11,LUZ-11	Others	Others
	Redaporfin, also known as F-2BMet or LUZ-11, is a photosensitizer for Photodynamic Therapy (PDT) of cancer. Redaporfin showed a high efficacy in the treatment of male BALB/c mice with subcutaneously implanted colon (CT26) tumours. Vascular-PDT with 1.5 mg
T77630	EP3 antagonist 4	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	EP3 antagonist 4 是一种 EP3 拮抗剂，对 hEP 有抑制作用， Ki 值为 2 nM。EP3 antagonist 4 在大鼠完整 PK 研究中显示出较低的体内清除率、高口服 AUC 和良好的生物利用度。EP3 antagonist 4 可用于研究糖尿病和细胞功能障碍。
TP2182	Lamin fragment	Others	Others
	Lamin fragment has a peptide sequence of Lys-Ala-Gly-Gln-Val-Val-Thr-Ile-Trp. Lamin polypeptides have an almost complete α-helical conformation with multiple α-helical domains separated by non-α-helical linkers that are highly conserved in length and amin
T76263	Beinaglutide
	Beinaglutide 是一种重组人 GLP-1(rhGLP-1) 多肽，与人 GLP-1(7-36) 具有几乎 100% 的同源性。Beinaglutide 在血糖控制、抑制食物摄入和胃排空和促进体重减轻方面表现出依赖于剂量的作用。Beinaglutide 具有研究超重/肥胖和非酒精性脂肪性肝炎 (NASH) 的潜力。
T62180	CB1/2 agonist 2	Others	Others
	CB1/2 agonist 2 (compound 23) 是一种有效的非选择性大麻素 (cannabinoid) 配体，其Ki 分别为 3.5 nM 和 1.2 nM。CB1/2 agonist 2 是一种 CB1 的完全激动剂，也是 CB2 竞争性反向激动剂。CB1/2 agonist 2 表现出抗伤害效果。
T62847	AMXI-5001	Others	Others
	AMXI-5001 是一种有效的、口服具有活力的 parp1/2 和微管聚合抑制剂。MXI-5001 对多种人类癌细胞显示出选择性抗肿瘤细胞毒性，其 IC50s 远低于现有的临床 PARP1/2 抑制剂。AMXI-5001 能够诱导已建立的肿瘤（包括很大的肿瘤）完全消退。
T70013	Pipendoxifene	Others	Others
	Pipendoxifene, also known as ERA-923, is a new antiestrogen with potential anticancer activity. ERA-923 potently inhibits estrogen binding to ER-alpha (IC50 = 14 nM). In ER-alpha-positive human MCF-7 breast carcinoma cells, ERA-923 inhibits estrogen-stimulated growth (IC50 = 0.2 nM) associated with cytostasis. In vitro, a MCF-7 variant with inherent resistance to tamoxifen (10-fold) or 4-OH tamoxifen (>1000-fold) retains complete sensitivity to ERA-923 . In preclinical models, ERA-923 has an imp...
TP2514	BPC 157 acetate Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val,GEPPPGKPADDAGLV	Others	Others
	Body Protection Compound 157 (BPC 157) is a pentadecapeptide derived from BPC, identified in gastric juice, exhibiting diverse biological activities. At 2 µg/ml, BPC 157 enhances primary rat tendon fibroblast cell migration and F-actin formation. Furthermore, doses of 0.01 and 10 µg/kg, intraperitoneally (i.p.), mitigate paw swelling, bone erosion, and mononuclear cell infiltration in the joints of rats with rheumatoid arthritis induced by complete Freund's adjuvant (CFA). It also diminishes gas...
T69985	Lifirafenib HCl	Others	Others
	Lifirafenib, also known as Beigene-283, is a Novel potent and selective RAF Kinase and EGFR inhibitor. BGB-283-displays Potent Antitumor Activity in B-RAF Mutated Colorectal Cancers. In vitro, BGB-283 potently inhibits B-RAFV600E-activated ERK phosphorylation and cell proliferation. It demonstrates selective cytotoxicity and preferentially inhibits proliferation of cancer cells harbouring B-RAFV600E and EGFR mutation/amplification. In B-RAFV600E CRC cell lines, BGB-283 effectively inhibits the ...
T36564	(S)-Acenocoumarol	Others	Others
	Acenocoumarol is a short-lived oral anti-coagulant, which, like warfarin, functions by inhibiting vitamin K epoxide reductase. It has higher intrinsic anticoagulant potency than warfarin and phenprocoumon, when evaluated in vitro. Acenocoumarol has a single chiral center that gives rise to two different enantiomeric forms. (S)-Acenocoumarol has a shorter plasma elimination half-life (1.8 hours) and faster plasma clearance (28.5 L/hour), compared to the (R)-enantiomer (6.6 hours, 1.9 L/hour). The...
T68457	GSK812397	Others	Others
	GSK812397 is a potent entry inhibitor of X4-tropic strains of HIV-1, as demonstrated in multiple in vitro cellular assays. GSK812397 is a noncompetitive antagonist of the CXCR4 receptor, with GSK812397 producing a concentration-dependent decrease in both an SDF-1-mediated chemotaxis and intracellular calcium release (IC50s were 0.34+/-0.01 nM and 2.41+/-0.50 nM, respectively). GSK812397 is effective against a broad range of X4- and X4R5-utilizing clinical isolates. The potency and efficacy of GS...
T65440	Sodium Thiosulfate Pentahydrate	Others	Others
	Sodium thiosulfate (Pentahydrate) is an antioxidant and antifungal. Sodium thiosulfate protects against cisplatin-induced hearing loss in children and is not associated with serious adverse events attributed to its use[3]. The addition of sodium thiosulfate, administered 6 hours after cisplatin chemotherapy, resulted in a lower incidence of cisplatin-induced hearing loss among children with standard-risk hepatoblastoma, without jeopardizing overall or event-free survival[4]. Calciphylaxis is a p...

化合物

Cat.No: T10466

Target: P2X Receptor

Cat.No: T2067

Synonym: NS 11394

Target: GABA Receptor

(±)-Zanubrutinib

Cat.No: TQ0039

Synonym: (±)-BGB-3111

Target: BTK

(S)-Enitociclib

Cat.No: T70388

Synonym: VIP152

Target: CDK

Oseltamivir phosphate

Cat.No: T1486

Synonym: GS 4104,磷酸奥司他韦

Target: Influenza Virus

Cat.No: T39584

Target: Histone Methyltransferase

Cat.No: T22986

Target: GPR

Tetradecylthioacetic acid

Cat.No: T9808

Target: PPAR

Cat.No: T6075

Synonym: 帕妥匹隆,Patupilone,EPO 906

Target: Apoptosis, Microtubule Associated, Antibiotic, Antifungal

Cat.No: T9542

Target: AChR

Cat.No: T21543

Target: TRP/TRPV Channel

Cat.No: T36466

Synonym: Ce6,Chlorin e6,CE6

Target: Parasite

(S)-Pomalidomide

Cat.No: T69989

Target: Others

Cat.No: T39938

Target: Others

Cat.No: T70681

Target: Others

Cat.No: T15167

Synonym: R-75231

Target: Others

PPARα agonist 1

Cat.No: T62266

Target: Others

Cat.No: T61305

Target: Others

Cat.No: T35480

Synonym: dBRD9-A

Target: Others

Acetyl neurotensin (8-13)

Cat.No: T76572

Tau Peptide (275-305) (Repeat 2 domain)

Cat.No: T40409

Cat.No: T40223

Target: Others

Cat.No: T80136

Target: Vasopressin Receptor

pTH (2-38) (human)

Cat.No: T81352

Cat.No: T36946

Synonym: PW0464

Target: Others

Cat.No: T35479

Target: PROTACs

AMXI-5001 hydrochloride

Cat.No: T63328

Target: Others

Cat.No: T11314

Synonym: APX001,E1211

Target: Others

Glucokinase activator 3

Cat.No: T72284

Target: Others

Cat.No: T78672

Target: Others

MI-888 free base

Cat.No: T71023

Target: Others

Cat.No: T60637

Target: Others

Cangrelor free acid

Cat.No: T70335

Target: Others

Cat.No: T76549

Endoglycoceramidase II (EGCase II)

Cat.No: T75406

Target: Others

Apraglutide TFA

Cat.No: T76001

Cat.No: T41164

Target: PROTACs

Cat.No: T76513

Cat.No: T34278

Synonym: F 2BMet,F2BMet,F-2BMet,LUZ11,LUZ 11,LUZ-11

Target: Others

EP3 antagonist 4

Cat.No: T77630

Target: Prostaglandin Receptor

Cat.No: TP2182

Target: Others

Cat.No: T76263

CB1/2 agonist 2

Cat.No: T62180

Target: Others

Cat.No: T62847

Target: Others

Cat.No: T70013

Target: Others

BPC 157 acetate

Cat.No: TP2514

Synonym: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val,GEPPPGKPADDAGLV

Target: Others

Lifirafenib HCl

Cat.No: T69985

Target: Others

(S)-Acenocoumarol

Cat.No: T36564

Target: Others

Cat.No: T68457

Target: Others

Sodium Thiosulfate Pentahydrate

Cat.No: T65440

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T1549	Raloxifene hydrochloride LY156758 hydrochloride,盐酸雷洛昔芬,Raloxifene HCl,LY139481 hydrochloride,Keoxifene hydrochloride,LY156758 (Keoxifene) HCl	Estrogen Receptor/ERR; Others; MAO; Estrogen/progestogen Receptor; Autophagy	Autophagy; Endocrinology/Hormones; Metabolism; Neuroscience; Others
	Raloxifene hydrochloride (LY156758 hydrochloride) 是一种选择性且可口服的雌激素受体调节剂，用于预防绝经后妇女的骨质疏松症。它对骨骼和胆固醇代谢具有雌激素激动作用，但对乳腺和子宫组织具有完全的雌激素拮抗作用。
TN1890	Lupeol acetate	Others; TNF; NOS	Apoptosis; Immunology/Inflammation; Others
	Lupeol acetate possesses antinociceptive, antifertility, and anti-inflammatory properties, the effect probably involves the opioid system, as indicated by the complete blockade of the opioid antagonist naloxone.

天然产物

Raloxifene hydrochloride

Cat.No: T1549

Synonym: LY156758 hydrochloride,盐酸雷洛昔芬,Raloxifene HCl,LY139481 hydrochloride,Keoxifene hydrochloride,LY156758 (Keoxifene) HCl

Target: Estrogen Receptor/ERR, Others, MAO, Estrogen/progestogen Receptor, Autophagy

Cat.No: TN1890

Target: Others, TNF, NOS

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00464	APE Protein, Human, Recombinant APEX,Apurinic-Apyrimidinic Endonuclease 1,APEN,DNA-(Apurinic...	Human	E. coli
	Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases, APE1 cleaves the AP site to allow resynthesis and ligation to complete repair. APE1 stimulates the DNA binding activity of many transcription factors, which participate in cancer promotion and progression. APE1 regulates the redox state of multiple transcription factors, such as c-Jun, c-Fos, NF-kB, p53. APEN is also involved in calcium-dependent down...
TMPJ-01395	NIP7 Protein, Human, Recombinant (His) KD93,NIP7,60S Ribosome Subunit Biogenesis Protein NIP7 Homol...	Human	E. coli
	60S Ribosome Subunit Biogenesis Protein NIP7 Homolog (NIP7) belongs to the NIP7 family. NIP7 contains one PUA domain, it is essential for the process of proper 27S pre-rRNA and 60S ribosome subunit assembly. NIP7 is a monomer form and interacts with NOL8 and SBDS, and may bind to RNA. In addition, NIP7 is one of the many trans-acting factors required for eukaryotic ribosome biogenesis, which interacts with nascent pre-ribosomal particles and dissociates as they complete maturation and are export...
TMPK-00495	CADM3 Protein, Cynomolgus, Recombinant (His) NECL1,IGSF4B,CADM3,TSLC1-like 1,GSF4B,NECL-1,TSLL1,SynCAM3,m...	Cynomolgus	HEK293 Cells
	Cell adhesion molecules belonging to the Cadm family, and in particular Cadm3 (axonal) and its heterophilic binding partner Cadm4 (Schwann cell), mediate these interactions along the internode.over-expressing Cadm3 on the surface of DRG neuron axons results in an almost complete inability by Schwann cells to form myelin segments. Axons of superior cervical ganglion (SCG) neurons, which do not normally support the formation of myelin segments by Schwann cells, express higher levels of Cadm3 compa...
TMPJ-00961	STAT1 Protein, Human, Recombinant Transcription Factor ISGF-3 Components p91/p84,STAT1,Signal ...	Human	E. coli
	Signal Transducer and Activator of Transcription 1-Alpha/Beta (STAT1) contains one SH2 domain and belongs to the transcription factor STAT family. When tyrosine- and serine-phosphorylated, STAT1 can form a homodimer termed IFN-gamma-activated factor (GAF), migrate into the nucleus and bind to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. STAT1 functions as signal transducer and transcription activator that mediates cellul...
TMPY-03786	PLAC9 Protein, Human, Recombinant (mFc) placenta specific 9,PLAC9	Human	HEK293 Cells
	PLAC9 belongs to the PLAC9 family. PLAC9 gene is a placental-enriched gene. There are other two placental-enriched genes: Plac1 and Plac8. Plac1 is strongly expressed in all trophoblast-derived cells in the placenta and has been described in 2. Plac8 expression is restricted to the spongiotrophoblast layer during development, whereas PLAC9 is weakly expressed though highly enriched in placenta. For both, cDNAs with complete open reading frames were recovered and exon-intron structures inferred f...
TMPY-04375	Casein Kinase 1 alpha Protein, Human, Recombinant (GST) CKIa,casein kinase 1, alpha 1,casein kinase 1, α1,CK1a,Casei...	Human	Baculovirus Insect Cells
	Casein kinase I isoform alpha, also known as CKI-alpha, CK1 and CSNK1A1, is a cytoplasm protein which belongs to theprotein kinase superfamily, CK1 Ser/Thr protein kinase family and casein kinase I subfamily. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. High expression of CSNK2A1, or concomitantly high expression of CSNK2A1, are independent prognostic factors of poor survival in NSCLC patients. CSNK2A1 are use...
TMPY-02285	Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural/NS2 Protein NS2 Protein	H1N1	E. coli
	Non-structural protein 2 (NS2) plays a crucial role in the hepatitis C virus (HCV) assembly. NS2 was predicted to be composed of three transmembrane (TM) segments. Hepatitis C virus (HCV) nonstructural protein 2 (NS2) is a hydrophobic, transmembrane protein that is required not only for NS2-NS3 cleavage but also for infectious virus production.NS2 protein is essential for hepatitis C virus (HCV) replication. NS2 protein was expressed and purified. Aptamers against NS2 protein were raised and ant...
TMPY-03963	CALCB Protein, Human, Recombinant (mFc) CGRP-II,calcitonin-related polypeptide β,calcitonin-related ...	Human	HEK293 Cells
	CALCB, also known as CGPR and calcitonin 2, belongs to the calcitonin family. CALCB is a calcitonin (CT) peptide which may play a role in the mediation of human inflammatory diseases. It is highly expressed in the skin, blood, and cerebrospinal fluid. CGRP immunolabeling (IL) was detected in epidermal keratinocytes at levels that were especially high and widespread in the skin of humans from locations afflicted with postherpetic neuralgia (PHN) and complex region pain syndrome type 1 (CRPS), of ...
TMPJ-00072	IL-18BPd Protein, Mouse, Recombinant (hFc) Interleukin 18 Binding Protein Isoform d,IL-18 BPd,Igifbp,In...	Mouse	HEK293 Cells
	Interleukin 18 binding protein (IL-18BP) is a physiological inhibitor that acts through binding to the receptor-binding site of IL-18. IL-18 stimulates INF-γ, which then stimulates 18BP production via NF-κB. The interaction between IL-18 and IL-18BP has a significant role in the inflammation process. IL-18 BPs have four isoforms, a, b, c and d, which are spliced by different ways. The IL-18 BP isoforms a and c each contain one immunoglobulin (Ig)-like C2-type domain which is essential to the bin...
TMPJ-01440	Cutinase Protein, Thermobifida fusca, Recombinant (His) Cutinase	Thermobifida fusca	E. coli
	Cutinase belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is cutin hydrolase. Cutinase is a serine esterase containing the classical Ser, His, Asp triad of serine hydrolases. The protein belongs to the alpha-beta class, with a central beta-sheet of 5 parallel strands covered by 5 helices on either side of the sheet. Cutin monomers released from the cuticle by small amounts of cutinase on fungal spore surfaces can g...
TMPY-02597	IL-37 Protein, Human, Recombinant FIL1Z,IL-37,白细胞介素,IL37,IL1F7,IL-1RP1,FIL1(ζ),IL1RP1,FIL1,白介素...	Human	E. coli
	Interleukin 1 family member 7, or interleukin 37 (IL1F7 / IL37 / IL-1H4) is a secretory protein belonging to the Interleukin 1 family. IL-1F7 was localized in human peripheral monocytic cells. It has been localized the expression of IL-1F7b protein in discrete cell populations including plasma cells and tumor cells. These data suggest that IL-1F7 may be involved in immune response, inflammatory diseases, and/or cancer. Through constructing an adenoviral vector that allows high-level expression i...
TMPY-02887	IFI30 Protein, Human, Recombinant (His) interferon γ inducible protein 30,IP30,IFI-30,GILT,IP-30,int...	Human	HEK293 Cells
	IFI30 belongs to the GILT family. This family includes the two characterized human gamma-interferon-inducible lysosomal thiol reductase (GILT) sequences: P13284 and Q9UL08. It also contains several other eukaryotic putative proteins with similarity to GILT. The aligned region contains three conserved cysteine residues. Besides, the two GILT sequences possess a C-X(2)-C motif that is shared by some of the other sequences in the family. This motif is thought to be associated with disulfide bond re...
TMPY-04936	BCL2A1 Protein, Human, Recombinant (His) BFL1,ACC1,ACC-2,GRS,ACC-1,HBPA1,BCL2 related protein A1,BCL2...	Human	E. coli
	B-cell lymphoma 2-related protein A1 (BCL2A1) is a member of the BCL-2 family of anti-apoptotic proteins that confers resistance to treatment with anti-cancer drugs. Immunohistochemical expression of Wnt11 and BCL2A1 in complete moles and normal villi. Bcl2 family proteins control mitochondrial apoptosis and its members exert critical cell type and differentiation stage-specific functions, acting as barriers against autoimmunity or transformation. Anti-apoptotic Bcl2a1/Bfl1/A1 is frequently der...
TMPY-02724	XCL2 Protein, Human, Recombinant (His) SCM1B,hCG_1729916,SCM-1b,chemokine (C motif) ligand 2,SCYC2	Human	Baculovirus Insect Cells
	XCL2 is a small cytokine belonging to the XC chemokine family. Chemokines are a group of cytokines. Members of this group of so-called C-Chemokines belong to the SCY family of cytokines and are designated XCL (L for ligand) followed by a number. XCL2 is the new designation of SCM-1-beta. XCL2 is highly related to another chemokine called XCL1. XCL2 gene is located on chromosome 1 in humans. XCL2 is predominantly expressed in activated T cells, but can also be found at low levels in unstimulated ...
TMPJ-01259	CD3 epsilon/CD3e Protein, Cynomolgus, Recombinant (aa 22-117, hFc) CD3 epsilon,T-cell antigen receptor complex, epsilon subunit...	Cynomolgus	HEK293 Cells
	T-cell surface glycoprotein CD3 epsilon chain, also known as CD3E, is a single-pass type I membrane protein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. The CD3 epsilon subunit of the T cell receptor (TCR) complex contains two defined signaling domains, a proline-rich sequence and an immune tyrosine activation m...
TMPH-00711	BioH Protein, E. coli, Recombinant (His & Myc) bioB,Carboxylesterase BioH,Biotin synthesis protein BioH,Pim...	E. coli	E. coli
	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters. E.coli employs a methylation and demethylation strategy to allow elongation of a temporarily disguised malonate moiety to a pimelate moiety by the fatty acid synthetic enzymes. BioH shows a preference for short chain fatty acid esters (acyl c...
TMPY-02240	STAT1 Protein, Human, Recombinant (His & GST) IMD31A,IMD31B,IMD31C,STAT91,CANDF7,signal transducer and act...	Human	Baculovirus Insect Cells
	STAT1 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT1 can be activated by various ligands, including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. It is a signal transducer and transcription activator that mediates cellular responses to interferons (IFNs),...
TMPY-03105	Ki67/MKI67 Protein, Human, Recombinant (GST) MIB-1,PPP1R105,marker of proliferation Ki-67,MIB-,KIA	Human	E. coli
	MKI67 contains 1 FHA domain and plays a key role in cell proliferation. During interphase, the MKI67 antigen can be exclusively detected within the cell nucleus, whereas in mitosis most of the protein is relocated to the surface of the chromosomes. MKI67 protein is present during all active phases of the cell cycle (G1, S, G2, and mitosis), but is absent from resting cells. MKI67 is an excellent marker to determine the growth fraction of a given cell population. The fraction of MKI67-positive tu...

重组蛋白

APE Protein, Human, Recombinant

Cat.No: TMPJ-00464

Species: Human

Expression System: E. coli

NIP7 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01395

Species: Human

Expression System: E. coli

CADM3 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00495

Species: Cynomolgus

Expression System: HEK293 Cells

STAT1 Protein, Human, Recombinant

Cat.No: TMPJ-00961

Species: Human

Expression System: E. coli

PLAC9 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-03786

Species: Human

Expression System: HEK293 Cells

Casein Kinase 1 alpha Protein, Human, Recombinant (GST)

Cat.No: TMPY-04375

Species: Human

Expression System: Baculovirus Insect Cells

Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural/NS2 Protein

Cat.No: TMPY-02285

Species: H1N1

Expression System: E. coli

CALCB Protein, Human, Recombinant (mFc)

Cat.No: TMPY-03963

Species: Human

Expression System: HEK293 Cells

IL-18BPd Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00072

Species: Mouse

Expression System: HEK293 Cells

Cutinase Protein, Thermobifida fusca, Recombinant (His)

Cat.No: TMPJ-01440

Species: Thermobifida fusca

Expression System: E. coli

IL-37 Protein, Human, Recombinant

Cat.No: TMPY-02597

Species: Human

Expression System: E. coli

IFI30 Protein, Human, Recombinant (His)

Cat.No: TMPY-02887

Species: Human

Expression System: HEK293 Cells

BCL2A1 Protein, Human, Recombinant (His)

Cat.No: TMPY-04936

Species: Human

Expression System: E. coli

XCL2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02724

Species: Human

Expression System: Baculovirus Insect Cells

CD3 epsilon/CD3e Protein, Cynomolgus, Recombinant (aa 22-117, hFc)

Cat.No: TMPJ-01259

Species: Cynomolgus

Expression System: HEK293 Cells

BioH Protein, E. coli, Recombinant (His & Myc)

Cat.No: TMPH-00711

Species: E. coli

Expression System: E. coli

STAT1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02240

Species: Human

Expression System: Baculovirus Insect Cells

Ki67/MKI67 Protein, Human, Recombinant (GST)

Cat.No: TMPY-03105

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T11295	Flibanserin-d4 BIMT-17BS D4,BIMT-17 D4,Flibanserin D4	Others	Others
	Flibanserin, a compound identified as BIMT-17, acts as a complete agonist at the serotonin 5-HT1A receptor, with a binding affinity (Ki) of 1 nM, while functioning as an antagonist at the 5-HT2A receptor with a 49 nM affinity. Flibanserin D4 represents a deuterium-labeled version of Flibanserin.

同位素标记化合物

Cat.No: T11295

Synonym: BIMT-17BS D4,BIMT-17 D4,Flibanserin D4

Target: Others

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