IDH1 Inhibitor 1

Name: IDH1 Inhibitor 1
Brand: TargetMol
SKU: T11613
Rating: 4.5 (1 reviews)

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产品编号 T11613Cas号 2234285-81-3

IDH1 Inhibitor 1 is an orally bioavailable, brain-penetrant, and selective mutant IDH1 inhibitor (IC50s: 0.021 μM, 0.045 μM, and 2.52 μM for IDH1R132H, IDH1R132C, and IDH1WT).

IDH1 Inhibitor 1

还可以

产品编号 T11613Cas号 2234285-81-3

IDH1 Inhibitor 1 is an orally bioavailable, brain-penetrant, and selective mutant IDH1 inhibitor (IC50s: 0.021 μM, 0.045 μM, and 2.52 μM for IDH1R132H, IDH1R132C, and IDH1WT).

规格	价格	库存
25 mg	¥ 16,100	10-14周
50 mg	¥ 21,300	10-14周
100 mg	¥ 27,500	10-14周

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生物活性

产品描述	IDH1 Inhibitor 1 is an orally bioavailable, brain-penetrant, and selective mutant IDH1 inhibitor (IC50s: 0.021 μM, 0.045 μM, and 2.52 μM for IDH1R132H, IDH1R132C, and IDH1WT).
靶点活性	IDH1 (R132C):0.045 μM , IDH1 (WT):2.52 μM , IDH1 (R132H):0.021 μM
体外活性	IDH1 Inhibitor 1 inhibits cellular HCT116-IDH1R132H/+ with an IC50 of 0.039 μM.
体内活性	IDH1 Inhibitor 1 is also profiled in a patient-derived IDH1 mutant HCT116-IDH1R132H/+ mechanistic xenograft tumor model in mice to evaluate in vivo inhibition of 2-HG production. IDH1 Inhibitor 1, dosed orally at 150 mg/kg, inhibits new 2-HG production.IDH1 Inhibitor 1 ?inhibits 2-hydroxyglutarate (2-HG) production in a preclinical xenograft tumor model.