Name: IDH1 Inhibitor 1
Brand: TargetMol
SKU: T11613
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

25 mg

¥ 13,900

10-14周

50 mg

¥ 18,300

10-14周

100 mg

¥ 23,500

10-14周

生物活性

产品描述	IDH1 Inhibitor 1 is an orally bioavailable, brain-penetrant, and selective mutant IDH1 inhibitor (IC50s: 0.021 μM, 0.045 μM, and 2.52 μM for IDH1R132H, IDH1R132C, and IDH1WT).
靶点活性	IDH1 (WT):2.52 μM , IDH1 (R132H):0.021 μM , IDH1 (R132C):0.045 μM
体外活性	IDH1 Inhibitor 1 inhibits cellular HCT116-IDH1R132H/+ with an IC50 of 0.039 μM.
体内活性	IDH1 Inhibitor 1 is also profiled in a patient-derived IDH1 mutant HCT116-IDH1R132H/+ mechanistic xenograft tumor model in mice to evaluate in vivo inhibition of 2-HG production. IDH1 Inhibitor 1, dosed orally at 150 mg/kg, inhibits new 2-HG production.IDH1 Inhibitor 1 ?inhibits 2-hydroxyglutarate (2-HG) production in a preclinical xenograft tumor model.

化学信息

分子量	450.39
分子式	C₂₀H₁₈F₄N₆O₂
CAS No.	2234285-81-3
Smiles	C[C@H](Nc1nccc(n1)N1[C@@H](CF)COC1=O)c1cn(cn1)-c1ccc(cc1)C(F)(F)F
密度	1.31g/cm3

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.

IDH1 Inhibitor 1