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TA01 是一种心源性抑制剂,有效抑制CK1和p38 MAPK,其对 CK1ε,CK1δ 和 p38 MAPK 的IC50值分别为 6.4 nM,6.8 nM 和 6.7 nM。
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TA01 是一种心源性抑制剂,有效抑制CK1和p38 MAPK,其对 CK1ε,CK1δ 和 p38 MAPK 的IC50值分别为 6.4 nM,6.8 nM 和 6.7 nM。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 189 | 现货 | |
5 mg | ¥ 447 | 现货 | |
10 mg | ¥ 713 | 现货 | |
25 mg | ¥ 1,290 | 现货 | |
50 mg | ¥ 1,930 | 现货 | |
100 mg | ¥ 2,910 | 现货 | |
200 mg | ¥ 3,960 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 530 | 现货 |
产品描述 | TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively. |
靶点活性 | p38 MAP kinase:6.7 nM, CKIϵ:6.4 nM , CKIδ:6.8 nM |
体外活性 | TA-01是一种强效的CK1和p38 MAPK抑制剂,其IC50分别为CK1ε(6.4 nM)、CK1δ(6.8 nM)和p38 MAPK(6.7 nM)。TA-01(5 μM)不具有细胞毒性,能完全抑制心脏发生,但在较低浓度时可以诱导心脏发生[1]。 |
激酶实验 | Compounds (TA-01) are dissolved in DMSO?and tested at?10 μM concentrations?against a panel of 97 kinases, which are related to stem cell differentiation and cell signaling pathways. Kinome profiling is carried out by kinase profiling service[1]. |
细胞实验 | HES-3, H7 and IPS are harvested and seeded at 1.1 × 106 cells/mL as EBs in ultra-low attachment 12-well plates in bSFS medium: DMEM supplemented with 2 mM l-glutamine, 0.182 mM sodium pyruvate, 1% non-essential amino acids, 0.1 mM β-mercaptoethanol, 5.6 mg/L transferrin, 20 μg/L sodium selenite, 0.25% (w/vol) Bovine Serum Albumin and 0.25% (w/vol) Hysoy. Cells are incubated at 37°C and 5% CO2 to allow EB formation. The medium is refreshed after 1 day and then every 2-3 days. Cells are stimulated with the respective compounds (TA-01) dissolved in DMSO (1 μL DMSO/mL of media) starting from day 1 or day 4, until day 8. CHIR99021 is applied for the first 24 h only[1]. |
分子量 | 351.32 |
分子式 | C20H12F3N3 |
CAS No. | 1784751-18-3 |
Smiles | Fc1ccc(cc1)-c1nc([nH]c1-c1ccncc1)-c1c(F)cccc1F |
密度 | 1.337 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
溶解度信息 | DMSO: 9 mg/mL (25.62 mM) | |||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||
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