GDC-0276

Name: GDC-0276
Brand: TargetMol
SKU: T11377
Price: 106 USD
Availability: InStock
Rating: 4.5 (1 reviews)

产品编号 T11377Cas号 1494581-70-2

GDC-0276, a potent, selective, reversible, and orally active NaV1.7 inhibitor with an IC50 value of 0.4 nM, offers potential for pain treatment while overcoming limitations associated with current pain medications, including addiction and off-target side effects. It is well tolerated and demonstrates a favorable pharmacokinetic profile.

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GDC-0276

纯度: 无数据

产品编号 T11377Cas号 1494581-70-2

规格	价格	库存
2 mg	¥ 3,330	5日内发货
5 mg	¥ 4,440	5日内发货
25 mg	¥ 11,700	6-8周
50 mg	¥ 15,300	6-8周
100 mg	¥ 19,500	6-8周

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TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

产品介绍

生物活性

产品描述	GDC-0276, a potent, selective, reversible, and orally active NaV1.7 inhibitor with an IC50 value of 0.4 nM, offers potential for pain treatment while overcoming limitations associated with current pain medications, including addiction and off-target side effects. It is well tolerated and demonstrates a favorable pharmacokinetic profile.
靶点活性	Nav1.7 electrophysiology:0.4 nM
体内活性	GDC-0276 is not detected in urine;?however, metabolites in urine were enriched in 14C with observed specific activities of 19.6 μCi/mg.e.GDC-0276 (oral adminstration; 0.5-5 mg/kg) shows enrichment of 14C with observed specific activities of 22.6 μCi/mg.