31
4
7
3
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12137 |
N-(2-Hydroxypropyl)methacrylamide
|
Parasite | Microbiology/Virology |
N-(2-Hydroxypropyl)methacrylamide 用于合成共聚物,用于靶向递送内脏利什曼病中的抗寄生虫剂。 | |||
T5491 |
GSK3179106
|
c-RET | Apoptosis; Tyrosine Kinase/Adaptors |
GSK3179106 是选择性的、具有口服活性的RET 激酶抑制剂,对人和大鼠 RET 的 IC50 分别为 0.4 nM 和 0.2 nM。它能够减轻炎症后和应激引起的内脏超敏反应,对肠易激综合征具有潜在的应用价值。 | |||
T2525 |
Alosetron hydrochloride
Lotronex,盐酸阿洛司琼,GR 68755C,GR 68755,GR 68755X |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Alosetron hydrochloride (GR 68755) 是一种高选择性的 5-HT3 受体拮抗剂,可减轻清醒或麻醉犬直肠扩张的内脏伤害性效应,具有抗炎活性,用于肠易激综合征的研究。它阻断 5HT3 介导的豚鼠肌间和粘膜下神经元的快速去极化,IC50约为 55 nM。 | |||
T0033 |
Miltefosine
HePC,米替福新,Hexadecyl phosphocholine |
Akt; HIV Protease; PKC | Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Miltefosine (HePC) 是一种广谱抗微生物剂,是治疗内脏和皮肤利什曼病的药物。它是 CTP 磷酸胆碱胞苷基转移酶的抑制剂。 | |||
T39746 |
DNDI-6148
|
Parasite | Microbiology/Virology |
DNDI-6148 具有抗实验性皮肤利什曼病活性,通过抑制利什曼原虫裂解和多聚腺苷酸化特异性因子 (CPSF3) 核酸内切酶起作用,可用于研究内脏利什曼病。 | |||
T33846 |
Oxyphenonium bromide
Spasmophen,Oxifenon,奥芬溴铵,Oxyfenon,Atrenyl,Oxyphenon |
Others | Others |
Oxyphenonium bromide (Oxyfenon) 具有抗胆碱能活性,可用于治疗胃和十二指肠溃疡以及缓解内脏痉挛的研究。 | |||
T39214L |
LXE408 fumarate
LXE408 fumarate (1799330-15-6 Free base) |
Proteasome | Proteases/Proteasome; Ubiquitination |
LXE408 fumarate 是一种口服有效的,非竞争性的,动素体选择性蛋白酶体 (proteasome) 抑制剂。LXE408 fumarate 抑制 L. donovani 蛋白酶体 (IC50=0.04 μM) 和 L. donovani (EC50=0.04 μM)。LXE408 fumarate 具有较弱的透过血脑屏障能力。LXE408 fumarate 具有用于内脏利什曼病 (VL) 研究的潜力。 | |||
T11661 |
INT-767
|
FXR; GPCR19 | GPCR/G Protein; Metabolism |
INT-767 是一种高效的法尼类固醇 X 受体 (FXR)/TGR5 双激动剂,可预防 NASH 并促进内脏脂肪棕色脂肪生成和线粒体功能,可用于研究非酒精性脂肪性肝炎。 | |||
T16448 |
PD173212
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
PD 173212是一种阻断 N-型电压敏感性钙通道 (N-type voltage sensitive calcium channel, Cav2.2)的阻滞剂。PD173212的腹腔注射给药(0.0017-1.7 μmol/kg)显著降低了2,4-二硝基苯磺酸(DNBS)诱导结肠炎小鼠的内脏超敏反应。 | |||
T7295 |
Miridesap
Ro63-8695,CPHPC,GSK2315698 |
Others | Others |
Miridesap (GSK2315698) 是一种血清淀粉样蛋白 P 组分 (SAP) 的配体,能够利用肝脏清除导致循环 SAP 的快速消耗。 它也可以明显减少脑脊液和内脏淀粉样蛋白沉积物中的 SAP。 | |||
T37427 |
(2R/S)-6-PNG
6-Prenylnaringenin,(±)-6-Prenylnaringenin |
Calcium Channel; HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism |
(2R/S)-6-PNG (6-Prenylnaringenin) 是新型天然组蛋白脱乙酰酶抑制剂,具有抗癌抗肿瘤活性,可阻断T型钙通道可减轻小鼠的神经性和内脏疼痛。 | |||
TP1057L |
Phe-Met-Arg-Phe Like Peptide acetate
Pqdpflrfamide acetate,Phe-Met-Arg-Phe Like Peptide acetate(98495-35-3 free base) |
Others | Others |
Phe-Met-Arg-Phe Like Peptide acetate (Pqdpflrfamide acetate)(98495-35-3 free base) 是一种来自蜗牛 Helix aspersa 的内脏和躯体肌肉的 FMRF 样肽。 FMRF (Phe-Met-Arg-Phe) 是一种由 4 个氨基酸残基组成的神经肽肽。 | |||
T71716 |
Nav1.1-IN-B
|
Others | Others |
Nav1.1-IN-B is a selective NaV1.1 inhibitor which reduces visceral hypersensitivity. | |||
T28346 |
PD-217014 HCl
PD 217014,PD217014,PD-217,014,PD-217014 |
Others | Others |
PD-217014 is a GABA analog. It inhibits (3)H-gabapentin binding to alpha(2)delta subunit of voltage-gated calcium channels in a concentration-dependent manner (K(i) = 18 nmol/l). PD-217014 possesses visceral analgesic activity. | |||
T71308 |
DSP-6952
|
Others | Others |
DSP-6952 is a 5-HT4 receptor partial agonist, inhibiting visceral hypersensitivity and ameliorating gastrointestinal dysfunction. | |||
T12970L |
Solabegron HCl
GW-427,353,GW427353,GW-427353,GW 427,353,GW427,353 |
Others | Others |
Solabegron (GW-427,353), is a selective agonist of β3 adrenergic receptors. In addition, Solabegron has been shown to produce visceral analgesia by releasing somatostatin from fat cells. | |||
TP1057 |
Phe-Met-Arg-Phe Like Peptide, Snail Helix aspersa
Phe-Met-Arg-Phe Like Peptide |
||
Phe-Met-Arg-Phe-like peptide, derived from the visceral and somatic muscles of the snail Helix aspersa, is a neuropeptide known as FMRF (Phe-Met-Arg-Phe). This peptide comprises four amino acid residues[1]. | |||
T33637 |
Neostibosan
Stibanilic acid,693B,Astaril,Ethylstibamine,p-Aminobenzenestibonic acid,Bayer 693 |
Others | Others |
Neostibosan is an arsenic-containing parasitic agent. Due to the activity of arsenic on visceral L/Ashmaniasis, one of the pentvalent antimony, which is less toxic, is synthesized and has potential activity on tumor cells. | |||
T35374L |
(Ala13)-Apelin-13 acetate
|
Apelin receptor | GPCR/G Protein |
(Ala13)-Apelin-13 acetate,一种 APJ 拮抗剂,可调节CRF 诱导的增强的结肠运动、内脏敏感性和肠屏障。 | |||
T71476 |
Afegostat TFA
|
Others | Others |
Afegostat, aslo known as Isofagomine, and AT2101, was an experimental drug for the treatment of certain forms of Gaucher's disease. Isofagomine (IFG) is an acid β-glucosidase (GCase) active site inhibitor that acts as a pharmacological chaperone. FG inhibits GCase with K(i) ~30 nM for wild-type and mutant enzymes (N370S and V394L). Administration of IFG (30 mg/kg/day) to the mice homozygous for GCase mutations (V394L, D409H, or D409V) led to increased GCase activity in visceral tissues and brain... | |||
T39214 |
LXE408
LXE408 |
Others | Others |
LXE408 is an orally active, kinetoplastid-selective proteasome inhibitor, exhibiting non-competitive inhibitory effects. It demonstrates an IC50 of 0.04 μM for L. donovani proteasome and an EC50 of 0.04 μM for L. donovani. Moreover, LXE408 shows limited ability to traverse the blood-brain barrier. Hence, LXE408 holds promise for advancing research in the field of visceral leishmaniasis (VL). | |||
T41183 |
Helianorphin-19
|
||
Helianorphin-19 is a high affinity, potent and selective κ-opioid receptor (KOR) agonist (Ki = 25 nM; EC50= 45 nM). Helianorphin-19 exhibits approximately 200-fold selectivity for KOR over μ and δ-opioid receptors.In vivoHelianorphin-19 shows potent peripheral analgesic efficacy in a mouse model of visceral pain without affecting motor coordination/sedation. | |||
T85064 |
1-1(Z)-Hexadecenyl-2-Palmitoyl-sn-glycero-3-PC
1-1(Z)-Hexadecenyl-2-Hexadecanoyl-sn-glycero-3-Phosphocholine,PC(P-16:0/16:0),C16(plasm)-16:0-PC,16:0p/16:0-PC,1-1(Z)-Hexadecenyl-2-Hexadecanoyl-sn-glycero-3-Phosphatidylcholine |
Others | Others |
1-1(Z)-Hexadecenyl-2-palmitoyl-sn-glycero-3-PC, a plasmalogen, appears in various rat tissues including the liver, heart, kidney, and both gluteus and soleus muscles, as well as visceral and subcutaneous adipose tissues. It serves in lipid bilayer synthesis to investigate how amphiphilic compounds, like lysophosphatidylcholine (1-palmitoyl-2-hydroxy-sn-glycero-3-PC) and lysoplasmenylcholine, influence membrane dynamics. | |||
T78559 |
PDE7-IN-3
|
Others | Others |
PDE7-IN-3(例2)是一种具有潜在镇痛活性的PDE7磷酸二酯酶抑制剂,可用于探究炎性、神经性、内脏性及伤害性疼痛。 | |||
T63186 |
Cav 3.2 inhibitor 1
|
Others | Others |
Cav 3.2 inhibitor 1为T型钙离子通道(calcium channel)抑制剂,其与多巴胺受体(D2 receptor)的结合亲和力较低,主要应用于研究身体和内脏疼痛。 | |||
T63606 |
Cav 3.2 inhibitor 2
|
Others | Others |
Cav 3.2 inhibitor 2 是一种 Cav3.2 T-type Ca2+channels 的抑制剂,-80mV 恒定电位下,其IC50=0.09339 μM。Cav 3.2 inhibitor 2 对小鼠 T 通道依赖性的躯体和内脏疼痛表现出有效的抑制作用。Cav 3.2 inhibitor 2 能够用于研究顽固性疼痛。 | |||
T85181 |
Urocortin II (human) TFA
|
Others | Others |
Urocortin II, a neuropeptide hormone within the corticotropin-releasing factor (CRF) family—which comprises mammalian CRF, urocortin I, urocortin III, frog sauvagine, and piscine urotensin I—displays 34, 43, and 37-40% sequence homology with rat and human CRF, human urocortin I, and human urocortin III, respectively. This compound enhances rabbit ventricular myocyte shortening and relaxation in both a time- and concentration-dependent manner. In vivo studies reveal that urocortin II lowers arter... | |||
T76127 |
Urocortin II, mouse
|
||
Urocortin II, mouse 是一种选择性的 2 型促肾上腺皮质激素释放因子 (CRF2) 受体内源性多肽激动剂,对CRFR2和CRFR1的Ki 值分别为 0.66 nM 和 ﹥100 nM。Urocortin II, mouse 通过以 cAMP/PKA 和 Ca2+/CaMKII 依赖性方式激活 CRF2 受体。Urocortin II, mouse 在中枢神经系统的离散区域表达,并激活参与内脏感觉信息处理和调节自主神经外流的中枢神经元。 | |||
T65387 |
Paromomycin, sulfate (1:1)
|
Others | Others |
Paromomycin (Sulfate Salt) is an aminoglycoside that is active against Gram-negative and many Gram-positive bacteria as well as some protozoa and cestodes. Paromomycin in combination with sodium stibogluconate has proven to be effective in African and Indian VL (visceral leishmaniasis) and improves survival in African VL[3]. PS (Paromomycin Sulfate) is effective for elimination of B. coli without hematological side effects[4]. The activity of phosphoglucose isomerase was slightly inhibited by 10... | |||
T83802 |
TNP-ATP sodium
|
||
TNP-ATP是ATP的衍生物,同时是嘌呤P2Y1、P2X3和P2X2/3受体的拮抗剂(IC50s分别为6、0.9和7 nM,在表达人类受体的HEK293细胞中)。该化合物相对于嘌呤P2X2、P2X4和P2X7受体显示出选择性(IC50s分别为2、15.2和>30 µM,在表达人类受体的HEK293细胞中)。TNP-ATP能降低表达P2X3和P2X2/3受体的1321N1细胞中乙酸诱导的钙流量(IC50s分别为100和62 nM)。它还可以减轻小鼠模型中由乙酸诱发的痛性绞曲(ED50 = 6.35 µmol/kg)。在403 nm激发下,其发射最大峰值为547 nm,当结合于胰岛素降解酶(IDE)时,其相对荧光强度增加四倍,并且发射峰移至538 nm。 | |||
T36373 |
Urocortin II (mouse) (trifluoroacetate salt)
|
||
Urocortin II is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF , urocortin , urocortin III , frog sauvagine, and piscine urotensin I.1 Mouse urocortin II shares 34 and 42% sequence homology with rat CRF and urocortin . It is expressed in mouse paraventricular, supraoptic, and arcuate nuclei of the hypothalamus, the locus coeruleus, and in motor nuclei of the brainstem and spinal ventral horn. Urocortin II selectively binds to CRF... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T20225 |
Dicentrine, (-)-
L-Dicentrine,荷包牡丹碱,NSC 251699,NSC251699,NSC-251699 |
Others | Others |
Dicentrine, (-)- (NSC-251699) 是一种在几种植物物种中发现的非卟啉生物碱,在小鼠内脏痛的急性模型中显示出显著的镇痛活性。 | |||
TN6791 |
Palvanil
Hexadecanamide |
TRP/TRPV Channel | Membrane transporter/Ion channel |
Palvanil (Hexadecanamide) 是一种快速脱敏的 TRPV1 激动剂。它可能是治疗 IBS 的有前途的药物,因为它可以调节肠道蠕动并减轻内脏疼痛。 | |||
T2P2923 |
Stearic acid
硬脂酸,Isostearic acid,Octadecanoic acid,Cetylacetic acid |
Phosphatase; Endogenous Metabolite | Metabolism |
Stearic acid (Cetylacetic acid) 是长链饱和脂肪酸,存在于许多动植物油脂中。 | |||
TN3568 |
Calceolarioside A
|
Calcium Channel; Antifection | Membrane transporter/Ion channel; Metabolism; Microbiology/Virology |
Calceolarioside A shows potent activity against visceral leishmaniasis. It can induce a dose-related aggregant effect on rabbit platelets, which may be partly related to a calcium-dependent mechanism. Calceolarioside A also has potent antioxidative activi |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00262 |
Serpin A12 Protein, Human, Recombinant (GST)
Visceral Adipose Tissue-Derived Serine Protease Inh... |
Human | E. coli |
Vaspin (Visceral Adipose-Specific SERPIN) is a newly described adipokine. Vaspin has three β-sheets, nine α-helices, and one central loop; the structure is part of the set of distinctive features that are descriptive of Serpin family members. Vaspin is also a unique insulin sensitizing adipocytokine in obesity. A recent publication indicates that Vaspin mRNA expression in visceral fat is positively correlated with BMI and percent of body fat. and could be associated with parameters of obesity, i... | |||
TMPY-02585 |
Acid sphingomyelinase/SMPD1 Protein, Mouse, Recombinant (His)
aSMase,ASM,Zn-SMase,A-SMase,sphingomyelin phosphodiesterase ... |
Mouse | Baculovirus Insect Cells |
Sphingomyelin phosphodiesterase 1 (SMPD1) , also known as ASM ( acid sphingomyelinase ), is a member of the acid sphingomyelinase family of enzymes. Three isoforms have been identified, isoform 1 is 631 amino acids (aa) in length as the pro form, while Isoform 2 and isoform 3 have lost catalytic activity. The active SMPD1 isoform 1 contains one saposin B-type domain that likely interacts with sphingomyelin, and a catalytic region. Human SMPD1 is 86% aa identical to mouse SMPD1. SMPD1 is a monome... | |||
TMPH-03341 |
Neurotrophin 3 Protein, Rat, Recombinant (His & Myc)
Neurotrophin-3,Neurotrophic factor,Nerve growth factor 2,HDN... |
Rat | E. coli |
Seems to promote the survival of visceral and proprioceptive sensory neurons. Neurotrophin 3 Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 21.1 kDa and the accession number is P18280. | |||
TMPH-01769 |
Neurotrophin 3 Protein, Human, Recombinant (His)
NTF3,HDNF,Neurotrophic factor,Neurotrophin-3,Nerve growth fa... |
Human | E. coli |
Seems to promote the survival of visceral and proprioceptive sensory neurons. Neurotrophin 3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 17.7 kDa and the accession number is P20783. | |||
TMPY-01893 |
Serpin A12 Protein, Human, Recombinant (His)
OL-64,serpin peptidase inhibitor, clade A (α-1 antiproteinas... |
Human | HEK293 Cells |
Serpins are the largest and most diverse family of protease inhibitors. Most serpins control proteolytic cascades, certain serpins do not inhibit enzymes, but instead perform diverse functions such as storage (ovalbumin, in egg white), hormone carriage proteins (thyroxine-binding globulin, cortisol-binding globulin) and tumor suppressor genes (maspin). Most inhibitory serpins target chymotrypsin-like serine proteases. These enzymes are defined by the presence of a nucleophilic serine residue in ... | |||
TMPK-00617 |
IL-13 Protein, Human, Recombinant (His & Avi)
NC30,ALRH,IL13,MGC116786,MGC116789,P600,MGC116788,BHR1,IL-13... |
Human | HEK293 Cells |
Interleukin-13 (IL-13) is a monomeric 17 kDa immunoregulatory cytokine that plays a key role in the pathogenesis of allergy, cancer, and tissue fibrosis. It is secreted by several helper T cell subsets, NK cells, mast cells, eosinophils, basophils, and visceral smooth muscle cells. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macro... | |||
TMPY-04445 |
PDK4 Protein, Mouse, Recombinant (His & GST)
AV005916,pyruvate dehydrogenase kinase 4 |
Mouse | Baculovirus Insect Cells |
Pyruvate dehydrogenase kinase 4 (PDK4) is a mitochondrial protein that regulates the TCA cycle.PDK4, a vital mitochondrial protein, controls the switch between glycolysis and oxidative phosphorylation based upon nutrient availability.Pyruvate dehydrogenase kinase 4 (PDK4) mRNA has been reported as an up-regulated gene in the heart and skeletal muscle of carnitine-deficient juvenile visceral steatosis (JVS) mice under fed conditions. PDK4 plays an important role in the inhibition of glucose oxida... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMID-0178 |
Stearic acid-18,18,18-d3
|
||
Stearic acid-18,18,18-d3 是 Stearic acid 的氘代化合物。Stearic acid 的 CAS 号为 57-11-4。Stearic acid是长链饱和脂肪酸,存在于许多动植物油脂中。 | |||
TMIJ-0052 |
Propionicacid-d5
|
||
Propionicacid-d5 是 Propionicacid 的氘代化合物。Propionicacid 的 CAS 号为 79-09-4。Propionic acid 被广泛用作食品中的抗真菌剂。它以低水平天然存在于乳制品中,并与其他短链脂肪酸 (SCFA) 一起普遍存在于人类和其他哺乳动物的胃肠道中,作为微生物消化碳水化合物的最终产物。在动物体内有显着的生理活性。 | |||
TMIJ-0054 |
Propionic-2,2-d2 acid
|
||
Propionic-2,2-d2 acid 是 Propionic acid 的氘代化合物。Propionic acid 的 CAS 号为 79-09-4。Propionic acid 被广泛用作食品中的抗真菌剂。它以低水平天然存在于乳制品中,并与其他短链脂肪酸 (SCFA) 一起普遍存在于人类和其他哺乳动物的胃肠道中,作为微生物消化碳水化合物的最终产物。在动物体内有显着的生理活性。 |