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Search Results for " vascularization "

Targets Recommended: AChR

6

抑制剂 & 化合物

7

化合物库

5

重组蛋白

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Cat. No.	Product Name
L2100	抗癌化合物库		7234 compounds
	7234 种肿瘤相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；
L2160	抗癌活性化合物库		3188 compounds
	3188 种具有抗肿瘤活性的化合物的特有集合，用于高通量、高内涵筛选；
L2150	抗癌药物库		3080 compounds
	3080 个具有抗癌活性小分子的独特集合，生物活性已经临床前实验证实，可用于高通量、高内涵筛选；
L2110	抗癌上市药物库		1779 compounds
	1779 个具有抗癌活性小分子的独特集合，所有化合物都经过了严格的临床前研究和临床试验，由FDA、EMA 或NMPA 批准上市，可用于高通量、高内涵筛选。
L2120	抗癌临床化合物库		2545 compounds
	2545 个具有抗癌活性小分子的独特集合，可用于高通量高内涵筛选。
L4800	血管生成库		1353 compounds
	1353 个高潜力的抑制或促进血管生成的小分子集合，可用于药物靶点开发、血管生成机理研究的高通量筛选，高内涵筛选；
L2180	抗肿瘤库Plus		1468 compounds
	1468 种抗肿瘤相关、结构新颖的化合物；

化合物库

抗癌化合物库

Cat.No: L2100

Compounds: 7234

抗癌活性化合物库

Cat.No: L2160

Compounds: 3188

抗癌药物库

Cat.No: L2150

Compounds: 3080

抗癌上市药物库

Cat.No: L2110

Compounds: 1779

抗癌临床化合物库

Cat.No: L2120

Compounds: 2545

血管生成库

Cat.No: L4800

Compounds: 1353

抗肿瘤库Plus

Cat.No: L2180

Compounds: 1468

Cat. No.	Product Name	Target	Signaling Pathways
T2141	Mecamylamine hydrochloride 盐酸美加明,Inversine,Mevasin	AChR	Neuroscience
	Mecamylamine hydrochloride (Mevasin) 是一种易穿过血脑屏障的烟碱拮抗剂，用作高血压的神经节阻滞剂，具有抗神经疾病作用。
T12205	Ned 19	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Ned 19 is a selective membrane-permeant non competitive antagonist of NAADP and strongly inhibits tumor growth and vascularization as well as lung metastases in mice.
T3024	Avitinib AC0010,艾维替尼	EGFR; JAK; BTK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Avitinib (AC0010) 是一种不可逆的、突变体选择性的EGFR 抑制剂，可有效抑制非小细胞肺癌中EGFR T790M 耐药突变。阿比替尼也是一种新型BTK 抑制剂。
T75156L	Bevasiranib sodium	Others	Others
	Bevasiranib sodium 是一种siRNA，可沉默产生血管内皮生长因子(VEGF)的基因。VEGF 在脉络膜新生血管形成(choroidal neo-vascularization, CNV)的发病机制中起着关键作用，而CNV 是湿性年龄相关性黄斑变性(wet age-related macular degeneration, wet AMD)的前兆。
T75156	Bevasiranib	Others	Others
	Bevasiranib 是一种siRNA，可沉默产生血管内皮生长因子(VEGF)的基因。VEGF 在脉络膜新生血管形成(choroidal neo-vascularization, CNV)的发病机制中起着关键作用，而CNV 是湿性年龄相关性黄斑变性(wet age-related macular degeneration, wet AMD)的前兆。
T84998	QLT0267	Others	Others
	QLT0267 is an inhibitor targeting integrin-linked kinase (ILK; IC50= 26 nM), showing over 10-fold selectivity against cyclin-dependent kinases 1, 2, and 5 (Cdk1, Cdk2, and Cdk5), and over 1,000-fold selectivity against C-terminal Src kinase (CSK), DNA-PK, Pim-1, Akt, PKC, and casein kinase 2 (CK2) at a concentration of 10 mg/ml. This compound effectively inhibits the proliferation of NPA187 papillary thyroid cancer cells with an IC50 of approximately 3 µM and induces apoptosis in NPA187, DRO, an...

化合物

Mecamylamine hydrochloride

Cat.No: T2141

Synonym: 盐酸美加明,Inversine,Mevasin

Target: AChR

Cat.No: T12205

Target: Calcium Channel

Cat.No: T3024

Synonym: AC0010,艾维替尼

Target: EGFR, JAK, BTK

Bevasiranib sodium

Cat.No: T75156L

Target: Others

Cat.No: T75156

Target: Others

Cat.No: T84998

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03962	AFM Protein, Human, Recombinant (His) afamin,ALBA,ALB2,ALF	Human	HEK293 Cells
	Afamin is an 87 kDa glycoprotein with five predicted N-glycosylation sites. Afamin's glycan abundance contributes to conformational and chemical inhomogeneity presenting great challenges for molecular structure determination. Afamin, a human plasma glycoprotein and putative transporter of hydrophobic molecules, has been shown to act as extracellular chaperone for poorly soluble, acylated Wnt proteins, forming a stable, soluble complex with functioning Wnt proteins. The 2.1-Å crystal structure of...
TMPJ-00071	EPO/Erythropoietin Protein, Human, Recombinant (His) Erythropoietin,EPO,红细胞生长素,Epoetin	Human	HEK293 Cells
	Erythropoietin (EPO) is a glycoprotein hormone that is principally known for its role in erythropoiesis, where it is responsible for stimulating proliferation and differentiation of erythroid progenitor cells. Erythropoietin is a member of the EPO/TPO family. It is a secreted, glycosylated cytokine composed of four alpha helical bundles. The differentiation of CFU-E (Colony Forming Unit-Erythroid) cells into erythrocytes can only be accomplished in the presence of EPO. Physiological levels of EP...
TMPK-00867	EMAP-II/AIMP1 Protein, Mouse, Recombinant (His) p43,SCYE1,HLD3,EMAP-II,AIMP1,EMAP-2	Mouse	E. coli
	The potent antiangiogenic and proinflammatory protein Endothelial Monocyte Activating Polypeptide II (EMAP II) has been described as a mediator of pulmonary vascular and alveolar formation and its expression is inversely related to the periods of vascularization and alveolarization in the developing lung. Hence the study of EMAP II could play a vital role in studying and devising appropriate therapeutics for diseases of aberrant lung development, such as BPD.
TMPH-02855	PML Protein, Mouse, Recombinant (His & Myc) Protein PML,Pml	Mouse	E. coli
	Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosp...
TMPY-01709	HIF-1 alpha Protein, Human, Recombinant (His) bHLHe78,HIF-1 α,hypoxia inducible factor 1, alpha subunit (b...	Human	E. coli
	HIF-1 alpha, also known as HIF1A, contains 1 basic helix-loop-helix (bHLH) domain, 1 PAC (PAS-associated C-terminal) domain, and 2 PAS (PER-ARNT-SIM) domains. It is one of the two subunits of Hypoxia-inducible factor-1 (HIF1). HIF1 is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has...

重组蛋白

AFM Protein, Human, Recombinant (His)

Cat.No: TMPY-03962

Species: Human

Expression System: HEK293 Cells

EPO/Erythropoietin Protein, Human, Recombinant (His)

Cat.No: TMPJ-00071

Species: Human

Expression System: HEK293 Cells

EMAP-II/AIMP1 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00867

Species: Mouse

Expression System: E. coli

PML Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02855

Species: Mouse

Expression System: E. coli

HIF-1 alpha Protein, Human, Recombinant (His)

Cat.No: TMPY-01709

Species: Human

Expression System: E. coli

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