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TMPH-03419
|
Rotavirus A (strain RVA/Human/United States/Wa/1974/G1P1A[8]) VP6 Protein (His)
Intermediate capsid protein VP6
|
RV-A
|
E. coli
|
|
Rotavirus A (strain RVA/Human/United States/Wa/1974/G1P1A[8]) VP6 Protein (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 50.9 kDa and the accession number is P03530. |
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TMPH-03062
|
Norovirus (strain Human/NoV/United States/Norwalk/1968/GI) VP1 Protein (Flag & Myc)
p59,Capsid protein VP1
|
Norwalk virus
|
HEK293 Cells
|
|
Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate the genomic RNA and VP2 proteins. Attaches virion to target cells by binding histo-blood group antigens present on gastroduodenal epithelial cells.; Soluble capsid protein may play a role in viral immunoevasion. |
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TMPY-02956
|
Apolipoprotein L/APOL1 Protein, Human, Recombinant (His)
APOL1,apolipoprotein L1,APOL,FSGS4,APOL-I,APO-L
|
Human
|
Baculovirus Insect Cells
|
|
APOL1, also known as apolipoprotein L1, is a minor apoprotein component of HDL (High-density lipoprotein) or 'good cholesterol' which is synthesized in the liver and also in many other tissues, including pancreas, kidney, and brain. APOL1 belongs to the apolipoprotein L family. It may play a role in lipid exchange and transport throughout the body. It may also participate in reverse cholesterol transport from peripheral cells to the liver. Defects in APOL1 are the cause of focal segmental glomer... |
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TMPY-03758
|
Vaccinia Virus B18R/B19R Protein (His)
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VACV
|
Baculovirus Insect Cells
|
|
B18R is a type I interferon (IFN)-binding protein, which is encoded by the B18R open reading frame in the WR (Western Reserve) strain of vaccinia virus. It is also known as B19R in the Copenhagen strain of Vaccinia. B18R exists in a soluble and a membrane-bound form. As a type I IFN receptor, B18R has a broad species specificity. It has high affinity for human IFN-alpha and also binds rabbit, bovine, rat, pig, and mouse IFN-alpha and IFN-beta. It has been shown that secreted B18R binds to un... |
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TMPJ-01065
|
Noggin/NOG Protein, Mouse, Recombinant (His)
Nog,Noggin
|
Mouse
|
HEK293 Cells
|
|
Noggin is a secreted homodimeric glycoprotein that is an antagonist of bone morphogenetic proteins (BMPs). Mouse Noggin cDNA encodes a 232 amino acid (aa) residue precursor protein with 19 aa residue putative signal peptide that is cleaved to generate the 213 aa residue mature protein which is secreted as a homodimeric glycoprotein. Secreted Noggin probably remains close to the cell surface due to its binding of heparin-containing proteoglycans. Noggin binds some BMPs such as BMP4 with high affi... |
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TMPJ-00815
|
FBPase1 Protein, Human, Recombinant (His, E. coli)
6-Bisphosphate 1-Phosphohydrolase 1,FBP1,FBP,FBPase 1,D-Fruc...
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Human
|
E. coli
|
|
Fructose-1,6-Bisphosphatase 1 (FBPase 1) is a member of the FBPase class 1 family. FBPase 1 is a gluconeogenesis regulatory protein, which catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. FBPase 1 can assume an active R-state, or an inactive T-state. FBPase 1 deficiency is inherited as an autosomal recessive disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis in newborn infants or young chi... |
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TMPH-02163
|
Syncytin-1 Protein, Human, Recombinant (His & SUMO)
Endogenous retrovirus group W member 1,Enverin,Env-W,Syncyti...
|
Human
|
E. coli
|
|
This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5.; Endogenous envelope proteins may have kept, lost or modified their original function during evolution. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein (SU) mediates receptor r... |
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TMPY-03981
|
CPLX3 Protein, Human, Recombinant (His)
CPXIII,Nbla11589,CPX-III,complexin 3
|
Human
|
HEK293 Cells
|
|
CPLX3, also known as complexin 3, belongs to the complexin/synaphin family. As a SNARE-binding protein, complexin (CPX), can act either as a facilitator or as an inhibitor of membrane fusion, constituting a controversial dilemma. CPX acts sequentially on assembling SNAREpins, first facilitating zippering by nearly doubling the distance at which v- and t-SNAREs can engage and then clamping them into a half-zippered fusion-incompetent state. Specifically, the central helix of CPX allows SNAREs to ... |
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TMPH-00522
|
Recombinase cre Protein, Enterobacteria phage P1, Recombinant (His & Myc)
cre,Recombinase cre
|
Escherichia phage P1
|
E. coli
|
|
Catalyzes site-specific recombination between two 34-base-pair LOXP sites. Its role is to maintain the phage genome as a monomeric unit-copy plasmid in the lysogenic state. |
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TMPH-02198
|
TXNRD2 Protein, Human, Recombinant (His & SUMO)
TR-beta,Thioredoxin reductase 2, mitochondrial,Thioredoxin r...
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Human
|
E. coli
|
|
Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis. Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling. |
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TMPH-02509
|
ANGPTL8 Protein, Mouse, Recombinant (E. coli, His)
Angiopoietin-like protein 8,Lipasin,Gm6484,Refeeding-induced...
|
Mouse
|
E. coli
|
|
Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state. According to a report, may act by promoting ANGPTL3 cleavage. According to another study, not required for cleavage of ANGPTL3. |
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TMPY-06623
|
CB2/CNR2 Protein, Human, Recombinant
CB2,CB-2,CX5
|
Human
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HEK293 Cells
|
|
Genetic variants within the CNR2 gene encoding the cannabinoid receptor CB2 are associated with osteoporosis and low bone mineral density (BMD) in case-control studies. There is a possibility that genetic variants of the CNR1 gene may produce a liability to the complication of psychotic state after abuse of methamphetamine. |
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TMPH-01671
|
Human metapneumovirus (strain CAN97-83) Fusion glycoprotein F0 (His & SUMO)
Fusion glycoprotein F0,F
|
HMPV
|
E. coli
|
|
Inactive precursor that is cleaved to give rise to the mature F1 and F2 fusion glycoproteins.; Class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and plasma cell membrane fusion, the coiled coil regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The forma... |
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TMPY-02805
|
GNGT1 Protein, Human, Recombinant (His)
guanine nucleotide binding protein (G protein), γ transducin...
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Human
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E. coli
|
|
GNGT1 is a subunit of transducin. Heterotrimeric G proteins consist of alpha, beta, and gamma subunits. They are membrane-bound GTPases that are linked to 7-TM receptors. They function as signal transducers for the 7-transmembrane-helix G protein-coupled receptors. They are involved as a modulator or transducer in various transmembrane signaling systems. G proteins are bound to GDP in the 'off' state. GNGT1 is the gamma subunit of transducin. Ligand-receptor binding results in detachment of the ... |
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TMPH-00206
|
Pertactin autotransporter Protein, Bordetella pertussis, Recombinant (His & SUMO)
prn,P.93,Pertactin autotransporter
|
Bordetella pertussis
|
E. coli
|
|
Agglutinogen that binds to eukaryotic cells; a process mediated by the R-G-D sequence. Pertactin may have a role in bacterial adhesion, and thus play a role in virulence. May contribute to the disease state of whooping cough. Pertactin autotransporter Protein, Bordetella pertussis, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 45.8 kDa and the accession number is P14283. |
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TMPH-01286
|
EEF2 Protein, Human, Recombinant (His)
Elongation factor 2,EEF2,EF2,EF-2
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Human
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E. coli
|
|
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. |
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TMPJ-01377
|
Testin Protein, Human, Recombinant (His)
TES,Testin,TESS
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Human
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E. coli
|
|
Testin belongs to the prickle/espinas/testin family. Testin contains three LIM zinc-binding domains and one PET domain, TES as a scaffold protein that may have a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. In addition, TES can also as a tumor suppressor, inhibits tumor cell growth, regulate the cell proliferation.TES interacts with many cytoskeletal proteins, such as Zyxin, Mena, Actin, Talin and VASP. The ability of TES to associate with alpha-acti... |
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TMPH-02510
|
ANGPTL8 Protein, Mouse, Recombinant (His)
Rifl,Refeeding-induced fat and liver protein,Betatrophin,Ang...
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Mouse
|
P. pastoris (Yeast)
|
|
Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state. According to a report, may act by promoting ANGPTL3 cleavage. According to another study, not required for cleavage of ANGPTL3. ANGPTL8 Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 22.5 kDa and the... |
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TMPK-00881
|
B7-2 Protein, Human, Recombinant (His & Avi), Biotinylated
LAB72,B7-2,B7-2 antigen,FUN-1,CD86 molecule,MGC34413,B70,B72...
|
Human
|
HEK293 Cells
|
|
B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimulatory receptors, CD28 and CTLA-4, is essential for the activation and regulation of T cell immunity. B7-1 and B7-2 do not form hetero-oligomers, underscoring the biological relevance of dimeric and monomeric state of B7-1 and B7-2, respectively. B7-2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian c... |
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TMPH-03443
|
GPX2 Protein, S. cerevisiae, Recombinant (His & Myc)
Glutathione peroxidase homolog 2,Glutathione peroxidase-like...
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Saccharomyces cerevisiae
|
E. coli
|
|
Glutathione peroxidase-like protein that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress. Plays an important role in the oxidative stress-induced response in the presence of Ca(2+). Has peroxidase activity using preferentially thioredoxin as a reducing power. The redox state of the mitochondrial GPX2 is regulated by TRX1 and TRX2 (cytoplasmic thioredoxin), and by TRX3 (mitochondrial matrix thioredoxin). Involved in sporulation. GPX2 Protein, ... |
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TMPJ-01192
|
ELAPOR1 Protein, Human, Recombinant (His)
ELAPOR1,Endosome-Lysosome Associated Apoptosis And Autophagy...
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Human
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HEK293 Cells
|
|
Endosome/lysosome-associated apoptosis and autophagy regulator (ELAPOR1), also known as EIG121 protein, is a type I transmembrane protein induced by estrogen. The estrogen-induced gene 121 (EIG121) has been associated with breast and endometrial cancers,but its mechanism of action remains unknown.May protect cells from cell death by inducing cytosolic vacuolization and upregulating the autophagy pathway. That EIG121 is a good endometrial biomarker associated with a hyperestrogenic state and estr... |
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TMPJ-00464
|
APE Protein, Human, Recombinant
APEX,Apurinic-Apyrimidinic Endonuclease 1,APEN,DNA-(Apurinic...
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Human
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E. coli
|
|
Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases, APE1 cleaves the AP site to allow resynthesis and ligation to complete repair. APE1 stimulates the DNA binding activity of many transcription factors, which participate in cancer promotion and progression. APE1 regulates the redox state of multiple transcription factors, such as c-Jun, c-Fos, NF-kB, p53. APEN is also involved in calcium-dependent down... |
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TMPH-00540
|
Epstein-Barr virus (strain GD1) LMP1 Protein (His)
LMP1,Protein p63,Latent membrane protein 1
|
EBV
|
P. pastoris (Yeast)
|
|
Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several signaling pathways, including those of the NF-kappa-B family. LMP1 signaling leads to up-regulation of antiapoptotic proteins and provide growth signals in latently infected cells. Interacts with host UBE2I and subsequently affects the sumoylation state of several cellular protein... |
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TMPK-00882
|
B7-2 Protein, Human, Recombinant (hFc)
B7-2,FUN-1,B7-2 antigen,CD86,LAB72,CD86 molecule,CD28LG2,B70...
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Human
|
HEK293 Cells
|
|
B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimulatory receptors, CD28 and CTLA-4, is essential for the activation and regulation of T cell immunity. B7-1 and B7-2 do not form hetero-oligomers, underscoring the biological relevance of dimeric and monomeric state of B7-1 and B7-2, respectively. B7-2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag.... |
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TMPH-01090
|
CBX8 Protein, Human, Recombinant (His)
Polycomb 3 homolog,hPc3,Pc3,Rectachrome 1,CBX8,Chromobox pro...
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Human
|
E. coli
|
|
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. CBX8 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. Th... |
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TMPY-02135
|
S100A16 Protein, Human, Recombinant
S100F,DT1P1A7,S100 calcium binding protein A16,MGC17528,AAG1...
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Human
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E. coli
|
|
S100A16 is a member of S100 protein superfamily that carries calcium-binding EF-hand motifs. S100 proteins are cell- and tissue-specific and are involved in many intra- and extracellular processes through interacting with specific target proteins. S100A16 expression was found to be astrocyte-specific. The S100A16 protein was found to accumulate within nucleoli and to translocate to the cytoplasm in response to Ca(2+) stimulation. The homodimeric structure of human S100A16 in the apo state has be... |
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TMPY-02802
|
GNG13 Protein, Human, Recombinant (His)
G(gamma)13,h2-35,G(γ)13,guanine nucleotide binding protein (...
|
Human
|
E. coli
|
|
GNG13 is a subunit of heterotrimeric G proteins which consist of alpha, beta, and gamma subunits. Heterotrimeric G proteins are membrane-bound GTPases that are linked to 7-TM receptors. They function as signal transducers for the 7-transmembrane-helix G protein-coupled receptors. They are involved as a modulator or transducer in various transmembrane signaling systems. Each G protein is composed of an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding... |
|
TMPJ-00946
|
TALDO1 Protein, Human, Recombinant (His)
Transaldolase,TALDO1,TAL,TALDOR,TALDO
|
Human
|
HEK293 Cells
|
|
Transaldolase (TALDO1) belongs to the transaldolase family of Type 1 subfamily. TALDO1 is expressed selectively in oligodendrocytes of the brain. TALDO1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. TALDO1 deficiency results in telangiectases of the sk... |
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TMPH-02175
|
TAF5L Protein, Human, Recombinant (GST)
TAF5L,TAF5-like RNA polymerase II p300/CBP-associated factor...
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Human
|
E. coli
|
|
Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. With TAF6L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state. |
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TMPK-00880
|
B7-2 Protein, Human, Recombinant (His & Avi)
B70,B7-2 antigen,B7-2,CD86 molecule,CD86,CD28LG2,MGC34413,BU...
|
Human
|
HEK293 Cells
|
|
B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimulatory receptors, CD28 and CTLA-4, is essential for the activation and regulation of T cell immunity. B7-1 and B7-2 do not form hetero-oligomers, underscoring the biological relevance of dimeric and monomeric state of B7-1 and B7-2, respectively. B7-2 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-Hi... |
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TMPY-03059
|
Tubulin cofactor A Protein, Human, Recombinant
tubulin folding cofactor A
|
Human
|
E. coli
|
|
Tubulin folding cofactor A belongs to the TBCA family. It is one of four proteins (cofactors A, D, E, and C) involved in the early step of the tubulin folding pathway. These proteins can fold intermediates and finally lead to correctly folded beta-tubulin. It is believed that tubulin folding cofactors A and D play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Tubulin folding cofactor E binds to the cofactor D/beta-tubulin complex; interaction with... |
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TMPU-00003
|
STAT2 Protein, Human, Recombinant (His)
|
Human
|
E. coli
|
|
Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of... |
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TMPJ-00961
|
STAT1 Protein, Human, Recombinant
Transcription Factor ISGF-3 Components p91/p84,STAT1,Signal ...
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Human
|
E. coli
|
|
Signal Transducer and Activator of Transcription 1-Alpha/Beta (STAT1) contains one SH2 domain and belongs to the transcription factor STAT family. When tyrosine- and serine-phosphorylated, STAT1 can form a homodimer termed IFN-gamma-activated factor (GAF), migrate into the nucleus and bind to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. STAT1 functions as signal transducer and transcription activator that mediates cellul... |
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TMPJ-00972
|
CDKN1B Protein, Human, Recombinant (His)
KIP1,CDKN1B,Cyclin-Dependent Kinase Inhibitor p27,Cyclin-Dep...
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Human
|
E. coli
|
|
Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B) is a Kinesin-related motor protein necessary for mitotic spindle assembly and chromosome segregation. CDKN1B is expressed in all tissues with highest levels observed in skeletal muscle. CDKN1B is a potent inhibitor of Cyclin E- and Cyclin A-CDK2 complexes. CDKN1B forms a complex with Cyclin Type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. In addition, CDKN1B acts as an inhibitor or an ... |
|
TMPK-00653
|
B7-2 Protein, Cynomolgus, Recombinant (His)
B72,MGC34413,LAB72,B7-2,FUN-1,B7-2 antigen,CD86,BU63,CD28LG2...
|
Cynomolgus
|
HEK293 Cells
|
|
B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimulatory receptors, CD28 and CTLA-4, is essential for the activation and regulation of T cell immunity. B7-1 and B7-2 do not form hetero-oligomers, underscoring the biological relevance of dimeric and monomeric state of B7-1 and B7-2, respectively. B7-2 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His... |
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TMPY-02240
|
STAT1 Protein, Human, Recombinant (His & GST)
IMD31A,IMD31B,IMD31C,STAT91,CANDF7,signal transducer and act...
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Human
|
Baculovirus Insect Cells
|
|
STAT1 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT1 can be activated by various ligands, including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. It is a signal transducer and transcription activator that mediates cellular responses to interferons (IFNs),... |
|
TMPY-00473
|
NRBF2 Protein, Human, Recombinant (His & GST)
NRBF-2,nuclear receptor binding factor 2,COPR2,COPR1
|
Human
|
Baculovirus Insect Cells
|
|
NRBF2 (Nuclear Receptor Binding Factor 2) is a Protein Coding gene. The encoded protein may modulate transcriptional activation by target nuclear receptors. It is widely expressed in the appendix, placenta, and other tissues. NRBF2/Atg38 has been identified as the fifth subunit of the macroautophagy/autophagy class III phosphatidylinositol 3-kinase (PtdIns3K) complex, along with ATG14/Barkor, BECN1/Vps30, PIK3R4/p150/Vps15, and PIK3C3/Vps34. NRBF2 is a critical molecular switch of PtdIns3K and a... |
|
TMPY-04771
|
CARKL Protein, Human, Recombinant (His & GST)
SHK,CARKL,sedoheptulokinase
|
Human
|
Baculovirus Insect Cells
|
|
CARKL, also known as SHPK, is a nonprotein kinase of glucose metabolism. CARKL has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. CARKL catalyzes an orphan reaction in the pentose phosphate pathway, refocusing cellular metabolism to a high-redox state upon physiological or artificial downregulation. CARKL-dependent metabolic reprogramming is required for proper M1- and ... |
|
TMPY-00176
|
FNDC4 Protein, Human, Recombinant (mFc)
fibronectin type III domain containing 4,FRCP1
|
Human
|
HEK293 Cells
|
|
FNDC4 acts as an anti-inflammatory factor on macrophages and improves mouse model of induced colitis. FNDC4 could suppress osteoclast formation via NF-kappaB pathway and downregulation of CXCL10. Analysis of binding of FNDC4 to different immune cell types reveals strong and specific binding to macrophages and monocytes. FNDC4 treatment of bone marrow-derived macrophages in vitro results in reduced phagocytosis, increased cell survival and reduced proinflammatory chemokine expression. Hence, trea... |
|
TMPH-00541
|
Epstein-Barr virus (strain AG876) LMP1 Protein (His & Myc)
Latent membrane protein 1,Protein p63,LMP1
|
EBV
|
E. coli
|
|
Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several signaling pathways, including those of the NF-kappa-B family. LMP1 signaling leads to up-regulation of antiapoptotic proteins and provide growth signals in latently infected cells. Interacts with host UBE2I and subsequently affects the sumoylation state of several cellular protein... |
|
TMPH-01551
|
IFNLR1 Protein, Human, Recombinant (His & SUMO)
Cytokine receptor class-II member 12,Likely interleukin or c...
|
Human
|
E. coli
|
|
The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primar... |
|
TMPH-00542
|
Epstein-Barr virus (strain Raji) LMP1 Protein (His)
Latent membrane protein 1,LMP1,Protein p63
|
EBV
|
P. pastoris (Yeast)
|
|
Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several signaling pathways, including those of the NF-kappa-B family. LMP1 signaling leads to up-regulation of antiapoptotic proteins and provide growth signals in latently infected cells. Interacts with host UBE2I and subsequently affects the sumoylation state of several cellular protein... |
|
TMPH-02585
|
ACOD1 Protein, Mouse, Recombinant (His & Myc)
Cis-aconitate decarboxylase,Cis-aconitic acid decarboxylase,...
|
Mouse
|
Baculovirus Insect Cells
|
|
Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the anti... |
|
TMPJ-00168
|
HVEM Protein, Mouse, Recombinant (hFc)
Tnfrsf14,Herpesvirus entry mediator,ATAR,Tumor necrosis fact...
|
Mouse
|
HEK293 Cells
|
|
Mouse Protein Tnfrsf14, is a type I transmembrane protein belonging to the TNF receptor superfamily. It is tumor necrosis factor receptor superfamily member 14 and expressed on the surface of T cells during the resting state. Interaction of HVEM with TNF family member LIGHT co-stimulates T cells and promotes inflammation. HVEM also triggers inhibitory signaling cascade in effector T (Teff) cells and regulatory T cells (Tregs) as a ligand of B and T lymphocyte attenuator. Tnfrsf14 is detected in ... |
|
TMPY-02582
|
Ferritin light chain Protein, Human, Recombinant (His)
NBIA3,LFTD,MGC71996,ferritin, light polypeptide
|
Human
|
E. coli
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Ferritin, light polypeptide (FTL) is the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Storage of iron in the tissues occurs in the form of ferritin and hemosiderin. The latter originates from ferritin that has undergone intracellular digestion of its protein shell, leaving the iron core. Ferritin and hemosiderin are components of a continuum. Fer... |
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TMPJ-00554
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Vinculin Protein, Human, Recombinant
Metavinculin,VCL,Vinculin
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Human
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E. coli
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Vinculin is a focal adhesion and cytoskeletal protein that distributed mainly at cell-cell junctions and cell-extracellular matrix (ECM) adhesion that belongs to the Vinculin/α-Catenin family. Vinculin is an Actin-binding protein and component of the Actin-Linking Functional module that senses and feels the mechanical properties of the extracellular environment. Vinculin is also a key factor that couples, transmits, transduces, and regulates mechanical force between the cytoskeleton and adhesion... |
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TMPJ-01055
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HBA1 Protein, Human, Recombinant (His)
α-globin,Hemoglobin subunit alpha,HBH,HBA-T3,Alpha-globin,He...
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Human
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E. coli
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Hemoglobin subunit alpha 1 (HBA1), also known as α2β2, is a hetero-tetramer consisting of two α and two β subunits held together by non-covalent interactions. Each subunit contains a heme group with an iron atom in the Fe2+ state. Cooperativity of Hemoglobin (Hb) in binding with O2 and allosteric regulatory binding properties with CO2, H+, Cl−, and 2,3-DPG (2,3-bisphosphoglycerate) are based on subunit interactions. HBA1 is the most common type of Hb in adult humans, which mediates the transport... |
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TMPJ-01473
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BMP-7 Protein, Human, Recombinant
Eptotermin alfa,OP-1,OP1,Osteogenic protein 1,Bone morphogen...
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Human
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HEK293 Cells
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Bone morphogenetic protein 7 (BMP7), also known as osteogenic protein-1 (OP-1) is a member of Transforming growth factor-β (TGF-β) family of proteins. Bone morphogenetic proteins were discovered in 1965 by Marshal Urist, of which BMP7 is of particular interest in this review being a leptin-independent anorexinogen and having role in energy expenditure in the brown adipose tissue, which makes it a potential target for preventing/treating obesity. As it has been established that Obesity displays a... |
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TMPY-00323
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Hepatitis C virus (HCV-1a) NS3 protease/helicase immunodominant region Protein (aa 1356-1459, GST)
NS3
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HCV
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E. coli
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HCV NS3 displays three enzymatic activities: serine protease, NTPase, and RNA helicase. HCV NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A, and NS5A-NS5B. HCV NS3 RNA helicase binds to RNA and unwinds dsRNA in the 3' to 5' direction, and likely RNA stable secondary structure in the template strand (By similarity). Cleaves and inhibits the host antiviral protein MAVS. NS3/NS4A complex also prevents phosphorylation of human IRF3, t... |
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TMPJ-00884
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CXCL9 Protein, Mouse, Recombinant (His)
Protein m119,C-X-C motif chemokine 9,γ-interferon-induced mo...
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Mouse
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HEK293 Cells
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Chemokine (C-X-C motif) ligand 9 (CXCL9, MIG), is a small cytokine belonging to the CXC chemokine family. CXCL9 functions as one of the three ligands of chemokine receptor CXCR3 which is a G protein-coupled receptor found predominantly on T cells. It together with CXCL10 and CXCL11, may activate CXCR3 by binding to it. CXCL9 serves as a cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. It has been observed that tumour e... |
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