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Cat. No. | Product Name | Target | Signaling Pathways |
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TP1422 |
Interleukin (IL)-6 Receptor
|
Others | Others |
Interleukin (IL)-6 Receptor 是一种肽,来源于白细胞介素6受体。 | |||
T21048L |
Interleukin 1beta acetate(117027-34-6 Free base)
|
||
Interleukin 1beta acetate(117027-34-6 Free base) 在生命科学相关研究中具有广泛的应用。 | |||
T5110 |
IRAK inhibitor 6
|
IRAK | Immunology/Inflammation; NF-κB |
IRAK inhibitor 6 是白细胞介素-1受体相关激酶-4的抑制剂(IC50:160 nM)。 | |||
T82060 |
Interleukin-6 fragment (human)
|
||
Interleukin-6 fragment (human) 是一种多效性细胞因子,由淋巴细胞及非淋巴细胞产生。该分子的编码基因位于人类第7号染色体,长度大约为5 kb。Interleukin-6 fragment (human) 在免疫响应、急性相应、炎症过程、癌症治疗及血液造血方面均有重要的潜在应用。 | |||
T12352L |
Oxidopamine hydrobromide
6-Hydroxydopamine hydrobromide,6-羟基多巴胺氢溴酸盐,6-OHDA hydrobromide |
Mitophagy; Dopamine Receptor; Autophagy | Autophagy; GPCR/G Protein; Neuroscience |
Oxidopamine hydrobromide (6-OHDA hydrobromide) 是一种神经递质多巴胺拮抗剂,可选择性地破坏多巴胺能神经元,是一种广泛使用的神经毒素。 | |||
T12352 |
Oxidopamine hydrochloride
6-Hydroxydopamine hydrochloride,6-OHDA hydrochloride,6-羟基多巴胺盐酸盐 |
Mitophagy; Dopamine Receptor; Autophagy | Autophagy; GPCR/G Protein; Neuroscience |
Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) 是一种神经递质多巴胺拮抗剂,可选择性地破坏多巴胺能神经元,是一种广泛使用的神经毒素。 | |||
T6761 |
Ossirene
AS101 |
IL Receptor; Caspase; Interleukin | Apoptosis; Immunology/Inflammation; Proteases/Proteasome |
Ossirene (AS101) 是一种免疫调节抑制剂,是一种新型 IL-1beta 转化酶抑制剂,可用于自身免疫性疾病和某些恶性肿瘤。它通过抑制IL-10消除 STAT3 的磷酸化,有效抑制Caspase-1。 | |||
TQ0181 |
Resatorvid
CLI-095,TAK-242,瑞沙托维 |
TNF; TLR; Autophagy; Interleukin | Apoptosis; Autophagy; Immunology/Inflammation |
Resatorvid (TAK-242) 是一种 Toll 样受体 4 (TLR4) 的抑制剂,具有选择性。Resatorvid 直接与 Cys747 结合,阻止 TLR4 与 TIRAP 结合,从而阻止下游信号转导。Resatorvid 具有抗肿瘤活性、抗炎活性和神经保护作用。 | |||
T27695 |
JTE-607
JTE-607 dihydrochloride,JTE-607 HCl,甲氧番荔枝碱 |
Cysteine Protease | Proteases/Proteasome |
JTE-607 HCl 是高选择性的炎性细胞因子合成抑制剂,可保护小鼠免受内毒素休克。它作用于 LPS 刺激的人 PBMC,抑制TNF-α(IC50:11 nM)、IL-1β(IC50:5.9 nM)、IL-6(IC50:8.8 nM)、IL-8(IC50:7.3 nM)和IL-10(IC50:9.1 nM)。 | |||
T4602 |
Hydrocortisone hemisuccinate
Hydrocortisone 21-he,氢化可的松琥珀酸酯,hydrocortisone 21-hemisuccinate*free acid,Hydrocortisone 21-hemisuccinate |
Glucocorticoid Receptor; Others; Interleukin | Endocrinology/Hormones; Immunology/Inflammation; Others |
Hydrocortisone hemisuccinate (hydrocortisone 21-hemisuccinate*free acid) 是糖皮质激素, 是口服有活性的甾体抗炎剂。它能够降低IL-6(IC50:6.7 μM)、IL-3(IC50:21.4 μM)的生物活性,可用于研究溃疡性结肠炎。 | |||
T9911 |
Tocilizumab
|
Interleukin | Immunology/Inflammation |
Tocilizumab 是抗人白细胞介素-6 受体 (IL-6R) 的中和抗体,能够阻碍 IL-6 与 IL-6R 的结合,进而抑制经典和反式信号。它可用于研究类风湿性关节炎,对重症 COVID-19 冠状病毒病方面的研究具有显著效果。 | |||
T76722 |
Sarilumab
REGN-88,SAR-153191 |
IL Receptor | Immunology/Inflammation |
Sarilumab(SAR-153191) 是一种有效的白细胞介素-6 IL-6 受体拮抗剂,是人源免疫球蛋白 G1 单克隆抗体。 Sarilumab 抑制由 IL-6 介导的信号传导,可减少炎症。Sarilumab 可用于预防和治疗类风湿关节炎。 | |||
T7606 |
Guanosine 5'-diphosphate disodium salt
5'-二磷酸鸟苷二钠,5'-GDP-Na2,鸟苷-5'-二磷酸二钠盐 |
Endogenous Metabolite | Metabolism |
Guanosine 5'-diphosphate disodium salt (5'-GDP-Na2) 是一种核苷二磷酸。它是一种潜在的铁动员剂,能够阻断铁调素-铁转运蛋白相互作用,也可以调节白 IL-6/stat-3 途径。 | |||
T67924 |
ABzOH
|
Others | Others |
ABzOH 是一种苯甲酸衍生物,结构类似于阿司匹林等非甾体抗炎药,具有抗炎、抗肿瘤和抗增殖作用。ABzOH 不仅可以抑制肿瘤坏死因子- α (TNF-a)、白细胞介素-1β (IL-1β)和白细胞介素-6 (IL-6)等促炎细胞因子的表达还对乳腺癌、肺癌和胰腺癌具有抑制作用。 | |||
T60739L |
Y13g dihydrochloride
Y13g 2HCl(T60739 Free base) |
IL Receptor; AChE | Immunology/Inflammation; Neuroscience |
Y13g dihydrochloride 是白细胞介素 6 (IL-6) 和乙酰胆碱酯酶 (AChE)的有效抑制剂(这两个靶点阿尔茨海默症 (AD) 进展的有关)。Y13g dihydrochloride 逆转 STZ 诱导的记忆缺陷,并表现出与正常动物相似的组织病理学。 | |||
T12781 |
RV01
|
Others | Others |
RV01 是一种新型的白藜芦醇喹啉取代类似物,可抑制 DNA 损伤,降低乙醇诱导的乙醛脱氢酶 (ALDH2) 的 mRNA 表达,具有清除羟自由基的活性。RV01 降低 iNOS 的表达,具有抗神经炎症作用。RV01降低肿瘤坏死因子-a (TNF-a)和白细胞介素-6 (IL-6) mRNA 水平和分泌,抑制lps 诱导的ROS 生成和烟酰胺腺嘌呤二核苷酸磷酸(NADPH)氧化酶活化,降低toll 样受体4 (TLR4)的蛋白表达,抑制lps 诱导的丝裂原活化蛋白激酶(MAPK)和核转录因子-кB (NF-кB)信号通路的激活。 | |||
T4403 |
AX-024 hydrochloride
AX-024 HCl |
IL Receptor; TNF; COX; IFNAR; Interleukin | Apoptosis; Immunology/Inflammation; Neuroscience |
AX-024 hydrochloride (AX-024 HCl) 是一种细胞因子释放抑制剂,可强烈抑制 IL-6、TNFα、IFN-γ、IL-10 和 IL-17A 的产生。它是口服可利用的 TCR-Nck 相互作用抑制剂,可选择性地抑制 TCR 触发的 T 细胞活化。它通过靶向 SH3结构域调节细胞信号传导,具有低毒、高效和高选择性的特点。 | |||
TP1516L |
C-Reactive Protein (CRP) 77-82 acetate
C-Reactive Protein (CRP) 77-82 acetate(130349-01-8 free base) |
Others | Others |
C-Reactive Protein (CRP) 77-82 acetate(130349-01-8 free base) 是 C-反应蛋白的 77-82 片段。 C-反应蛋白 (CRP) 是炎症的原型标志物,是心血管风险标志物,可能促进动脉粥样硬化。C-反应蛋白 (CRP) 是一种环状(环状)五聚体蛋白,存在于血浆中,其循环浓度炎症反应而升高。它是一种肝脏来源的急性期蛋白,在巨噬细胞和 T 细胞分泌 IL-6 后会增加。 | |||
T2548 |
Diflorasone
|
Glucocorticoid Receptor | Endocrinology/Hormones |
Diflorasone 是一种皮质类固醇激素受体激动剂,具有抗炎和免疫抑制作用。它可通过细胞膜扩散进入细胞,并与细胞质中的糖皮质激素受体结合。它用于研究湿疹、牛皮癣等皮肤病。 | |||
T71639 |
AUH-6-96
|
Others | Others |
AUH-6-96 is an inhibitor of JAK/STAT signaling, inhibiting both constitutive and interleukin-6-induced STAT3 phosphorylation, selectively affecting cell viability only of cancer cells harboring aberrant JAK/STAT signaling. | |||
T19854 |
Evoxine
|
Others | Others |
Evoxine is a selective inhibitor of CO2-induced immune suppression. It inhibits hypercapnic suppression of interleukin-6 and the chemokine CCL2 expression in human THP-1 macrophages. | |||
T39903 |
PROTAC IRAK4 degrader-6
PROTAC IRAK4 degrader-6 |
Others | Others |
PROTAC IRAK4 degrader-6 is a potent Cereblon-based compound designed to degrade interleukin-1 receptor-associated kinase 4 (IRAK4). | |||
T34811 |
Terrein
NSC 291308,土曲霉酮,Terrain,(+)Terrein,NSC291308,NSC-291308 |
Others | Others |
Terrain, also known as NSC 291308, is a fungal metabolite with diverse biological activities. Terrein reduces age-related inflammation induced by oxidative stress through Nrf2/ERK1/2/HO-1 signalling in aged HDF cells. (+)-terrein suppresses interleukin-6/ | |||
T76753 | Olokizumab | ||
Olokizumab (CDP 6038) 是一种人源化单克隆抗体,靶向白细胞介素-6 (IL-6),适用于类风湿关节炎 (RA) 的研究。 | |||
T79256 |
DPP-4-IN-8
|
Others | Others |
DPP-4-IN-8 (compound 27) 是一种高效的选择性DPP4抑制剂,具有 0.96 μM 的 Ki。该化合物能够抑制 Caco-2 和 HepG-2 细胞中的 DPP4 二肽酶活性,并剂量依赖性地降低 TNF-α、IL-6 和 IL-1β 的表达水平[1]。 | |||
T69223 |
CC-1088
|
Others | Others |
CC-1088 is an analog of thalidomide with potential antineoplastic activity that belongs to the functional class of agents called selective cytokine inhibitory drugs (SelCIDs). SelCIDs inhibit phosphodiesterase-4 (PDE 4), an enzyme involved in tumor necrosis factor alpha (TNF alpha) production. CC-1088 inhibits production of the cytokines vascular endothelial growth factor (VEGF) (a pro-angiogenic factor) and interleukin-6 (IL-6). | |||
T60739 |
Y13g
|
Others | Others |
Y13g 是白细胞介素 6 (IL-6) 和乙酰胆碱酯酶 (AChE)的有效抑制剂, 这两个靶点阿尔茨海默症 (AD) 进展的有关。Y13g 逆转 STZ 诱导的记忆缺陷,并表现出与正常动物相似的组织病理学。 | |||
T77062 | Levilimab | ||
Levilimab (BCD-089),一种全人源性抗IL-6R单克隆抗体,作为炎症缓解抗体用于类风湿研究。 | |||
T76712 | Satralizumab | ||
Satralizumab为一种人源化单克隆抗体,有效抑制白细胞介素-6(IL-6)。此抗体能防止dTAA在褐家鼠中的形成与发展,并可应用于视神经脊髓炎(NMOSD)及降胸主动脉动脉瘤(dTAA)的研究。 | |||
T76803 | Elsilimomab | ||
Elsilimomab (B-E8) 是一种抗白介素-6 (IL-6) 的 IgG1单克隆抗体,其 KD 为 22 pM,IC50为 1.4 nM。Elsilimomab 可用于多发性骨髓瘤、肾细胞癌和类风湿性关节炎 (RA) 的研究。 | |||
T73372 |
GNE-2256
|
Others | Others |
GNE-2256 (molecule 19) 是一种具有口服活性的IRAK4(白介素 1 受体关联激酶 4) 抑制剂 (IRAK4Ki=1.4 nM ; IL-6IC50=190 nM)。 | |||
T76675 | Clazakizumab | ||
Clazakizumab是一种具有高亲和力和特异性的单克隆抗体,针对IL-6(白细胞介素-6)细胞因子。它可能对抑制COVID-19中因SARS-CoV-2引起的细胞因子反应有帮助。此外,Clazakizumab也被用于研究银屑病关节炎(PsA)和肾抗体介导的排斥反应。 | |||
T71176 |
Atiprimod (free base)
|
Others | Others |
Atiprimod is an orally bioavailable small molecule belonging to the azaspirane class of cationic amphiphilic agents with anti-inflammatory, antineoplastic, and antiangiogenic properties. Atiprimod inhibits the phosphorylation of signal transducer and activator of transcription 3 (STAT3), blocking the signalling pathways of interleukin-6 and vascular endothelial growth factor (VEGF) and downregulating the anti-apoptotic proteins Bcl-2, Bcl-XL, and Mcl-1, thereby inhibiting cell proliferation, ind... | |||
T72120 |
Guanosine 5'-diphosphate sodium
GDP sodium |
Others | Others |
Guanosine 5'-diphosphate (GDP) sodium 是一种核苷二磷酸,可激活 5'-三磷酸腺苷敏感的 K+通道。Guanosine 5'-diphosphate sodium 是一种潜在的铁动员剂,可阻断铁调素-铁转运蛋白 (hepcidin-ferroportin) 相互作用并调节 IL-6/stat-3通路。Guanosine 5'-diphosphate sodium 可用于炎症研究,如炎症性贫血 (AI)。 | |||
T69451 |
R-130823
|
Others | Others |
R-130823 is a ighly selective inhibition against mitogen-activated protein kinase p38alpha (IC50=22 nM). The release of tumor necrosis factor-alpha, interleukin-1beta, -6 and -8 was inhibited in lipopolysaccharide-stimulated human blood pretreated by R-130823 , with IC50 values of 0.089, 0.066, 0.95 and 0.16 microM, respectively. R-130823 reduced the established hind paw swelling in rat adjuvant-induced arthritis, while methotrexate showed no suppression. In the same model, R-130823 ameliorated ... | |||
T68306 |
INCB16562
|
Others | Others |
INCB16562 is a novel, selective, and orally bioavailable small-molecule inhibitor of JAK1 and JAK2 markedly selective over JAK3. Treatment of myeloma cells with INCB16562 potently inhibited interleukin-6 (IL-6)-induced phosphorylation of STAT3. INCB16562 abrogated the protective effects of recombinant cytokines or bone marrow stromal cells and sensitized myeloma cells to cell death by exposure to dexamethasone, melphalan, or bortezomib. Oral administration of INCB16562 antagonized the growth of ... | |||
T85063 |
GHK-Cu acetate
Gly-His-Lys-Cu(II) |
Others | Others |
GHK-Cu acetate, a complex of the tripeptide Gly-His-Lys and a copper(II) ion, exhibits wound healing and anti-inflammatory properties. It enhances fibroblast proliferation, collagen production, and the release of pro-matrix metalloproteinase-2 (MMP-2) and glycosaminoglycans (GAGs), while also increasing decorin expression in rat wound tissue. Furthermore, at a concentration of 10 µM, it reduces levels of reactive oxygen species (ROS), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α)... | |||
TP1516 |
C-Reactive Protein (CRP) (77-82)
C-Reactive Protein (CRP) 77-82 |
||
C-Reactive Protein (CRP) 77-82 is the 77-82 fragment of C-Reactive Protein. C-Reactive Protein (CRP), the prototypic marker of inflammation, is a cardiovascular risk marker and may promote atherogenesis.C-reactive protein (CRP) is an annular (ring-shaped) | |||
T37604 |
ITK inhibitor
|
Others | Others |
Interleukin-2-inducible T cell kinase (ITK) is a non-receptor tyrosine kinase expressed in T cells, NKT cells and mast cells which plays a crucial role in regulating the T cell receptor (TCR), CD28, CD2, chemokine receptor CXCR4, and FcepsilonR-mediated signaling pathways. ITK inhibitors can be used for the treatment of inflammation and immune-mediated disorders. ITK inhibitor (N-[5-[[3-[(4-Acetylpiperazin-1-yl)carbonyl]-4-methyl-6-methoxy-phenyl]thio]thiazol-2-yl]-4-(N-1,2-dimethylpropylaminome... | |||
T63893 |
Adenylyl cyclase type 2 agonist-1
|
Others | Others |
Adenylyl cyclase type 2 agonist-1 是腺苷酸环化酶 2 型 (AC2) 有效的激动剂 (EC50: 90 nM)。Adenylyl cyclase type 2 agonist-1 能够抑制 Interleukin-6 的表达,是一种潜在的对抗呼吸系统疾病的先导化合物。 | |||
T36668 |
Geranylgeranoic Acid
|
Others | Others |
Geranylgeranoic acid (GGA) is an isoprenoid that has been found inS. chinensisand has anticancer activity.1It induces apoptosis in Huh7 and PLC/PRF/5 human hepatoma cells and MLE-10 transformed mouse hepatocytes, but not primary mouse hepatocytes, when used at concentrations ranging from 1 to 20 μM. GGA (10 μM) induces apoptosis in Huh7 cellsvialoss of the mitochondrial membrane potential and activation of interleukin-1β-converting enzyme (ICE) and cysteine protease precursor 32 (CPP32).2It also... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2758 |
Madecassic acid
6-Deoxy-L-Galactose,羟基积雪草酸,L-Fucose,Brahmic acid,L-fucopyranose |
Others; TNF; COX; NO Synthase; Interleukin | Apoptosis; Immunology/Inflammation; Neuroscience; Others |
Madecassic acid (L-fucopyranose) 是分离自积雪草的一种天然产物,抑制iNOS、COX-2、TNF-α、IL-1beta 和IL-6,可通过在 RAW 264.7 巨噬细胞中下调NF-κB 激活而具有抗炎作用。 | |||
T2893 |
Muscone
3-Methylcyclopentadecanone,Methylexaltone,麝香酮 |
MMP; TNF; NF-κB; NOD-like Receptor (NLR); P-gp; Interleukin | Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; NF-κB; Proteases/Proteasome |
Muscone (3-Methylcyclopentadecanone) 是中药麝香的一种主要活性单体。它抑制NF-κB 和NLRP3炎性小体的活化,显著降低炎性细胞因子水平,并最终改善心脏功能和存活率。 | |||
T7210 |
Guanosine 5'-diphosphate
GDP,鸟苷-5ˊ-二磷酸 |
Endogenous Metabolite | Metabolism |
Guanosine 5'-diphosphate (GDP) 是核苷二磷酸,是潜在的铁动员剂,能够阻断铁调素-铁转运蛋白相互作用并调节白细胞介素-6 (IL-6)/stat-3 途径。 | |||
T3926 |
Echinatin
刺甘草查尔酮,Retrochalcone |
Free radical scavengers | oxidation-reduction |
Echinatin (Retrochalcone) 是分离自中草药甘草中,具有保肝和抗炎活性。在大鼠中,它可以被快速吸收和消除,并广泛分布,绝对生物利用度约为 6.81%。 | |||
T6S1597 |
Mulberroside A
桑皮苷 A,桑皮苷A |
TNF; Tyrosinase; Interleukin | Apoptosis; Immunology/Inflammation; Proteases/Proteasome |
Mulberroside A 是桑中的一种主要活性成分,可降低TNF-α、IL-1β和IL-6的表达,抑制 NALP3、caspase-1 和 NF-κB 的激活以及 ERK、JNK 和 p38 的磷酸化 。它抑制蘑菇酪氨酸酶,具有抗炎和抗细胞凋亡作用。 | |||
T0798 |
Triamcinolone
Fluoxyprednisolone,曲安西龙,Aristocort,Rodinolone |
Glucocorticoid Receptor; COX | Endocrinology/Hormones; Immunology/Inflammation; Neuroscience |
Triamcinolone (Aristocort) 是一种皮质类固醇激素受体激动剂,也是一种合成的长效糖皮质激素,具有抗炎活性。 | |||
T2S2264 |
Linalool
Linalol,(±)-Linalool,Phantol,沉香醇 |
Apoptosis; IL Receptor; TNF; Endogenous Metabolite; iGluR | Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Linalool (Linalol) 是存在芫荽等植物中的单萜类天然产物,是竞争性NMDA 受体拮抗剂,具有抗肿瘤和抗心脏毒性的作用。它通过激活 Nrf2 诱导抗氧化防御和通过抑制 NF-κB 减少炎症反应来保护其免受 LPS/GalN 诱导的肝损伤,具有镇痛、抗菌和抗炎的特性。 | |||
TMA2576 |
Episappanol
|
IL Receptor; TNF | Apoptosis; Immunology/Inflammation |
Episappanol has anti-inflammatory activity , it can significantly inhibit the secretion of the pro-inflammatory cytokines interleukin (IL-6) and tumor necrosis factor-alpha (TNF-α). | |||
TN3603 |
Carpinontriol B
|
IL Receptor; Antifection | Immunology/Inflammation; Microbiology/Virology |
Carpinontriol B has antimicrobial activity, it at 40 ug/disk caused the formation of zones of inhibition. It also has anti-inflammatory activity, it shows considerable inhibition on the production of nitric oxide and reduces the production of interleukin-6 in dose-dependent manner in RAW 264.7 cells. | |||
TN4190 | Hedycoronen A | IL Receptor; TNF | Apoptosis; Immunology/Inflammation |
Hedycoronen A and hedycoronen B have the potential anti-inflammatory benefits, they are potent inhibitors of LPS-stimulated interleukin-6 (IL-6) and IL-12 p40, with IC(50) ranging from 4.1±0.2 to 9.1±0.3 uM, they also show moderate inhibitory activity on | |||
TN4490 | Manassantin B | ERK; BCL; p38 MAPK; TNF; NF-κB; JNK; STAT; Antifection | Apoptosis; JAK/STAT signaling; MAPK; Microbiology/Virology; NF-κB; Stem Cells |
Manassantin B is a potent inhibitor of NF-κB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-κB. It also possesses anti-EBV lytic replication activity. Manassantin B inhibits interleukin-6-induced signal transducer and activator of transcription 3 activation in Hep3B cells, it has potential as a potent anti-inflammatory drug for use in pathological processes such as sepsis or acute lung injury. Manassantin B exerts antifibrotic activity in HSC-T6 cells, in pa... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMID-0254 |
Linalool-d3
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Linalool-d3 是 Linalool 的氘代化合物。Linalool 的 CAS 号为 78-70-6。Linalool 是存在芫荽等植物中的单萜类天然产物,是竞争性NMDA受体拮抗剂,具有抗肿瘤和抗心脏毒性的作用。它通过激活 Nrf2 诱导抗氧化防御和通过抑制 NF-κB 减少炎症反应来保护其免受 LPS/GalN 诱导的肝损伤,具有镇痛、抗菌和抗炎的特性。 |