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Anti-IL6ST Monoclonal Antibody
产品编号 TMAZ-0043
别名 Interleukin-6 receptor subunit beta, Interleukin-6 signal transducer, Membrane glycoprotein 130, CDw130, Oncostatin-M receptor subunit alpha
Anti-IL6ST Monoclonal Antibody is a rabbit antibody targeting IL6ST. Anti-IL6ST Monoclonal Antibody can be used in ELISA, FACS, IF.
Anti-IL6ST Monoclonal Antibody
Anti-IL6ST Monoclonal Antibody
产品编号 TMAZ-0043 别名 Interleukin-6 receptor subunit beta, Interleukin-6 signal transducer, Membrane glycoprotein 130, CDw130, Oncostatin-M receptor subunit alpha
Anti-IL6ST Monoclonal Antibody is a rabbit antibody targeting IL6ST. Anti-IL6ST Monoclonal Antibody can be used in ELISA, FACS, IF.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 μg | ¥ 488.36¥ 842 | 7日内发货 | |
| 50 μg | ¥ 585.8¥ 1,010 | 7日内发货 | |
| 100 μg | ¥ 820.12¥ 1,414 | 7日内发货 |
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偶联与修饰
抗原信息
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| 产品描述 | Anti-IL6ST Monoclonal Antibody is a rabbit antibody targeting IL6ST. Anti-IL6ST Monoclonal Antibody can be used in ELISA, FACS, IF. |
| 别名 | Interleukin-6 receptor subunit beta, Interleukin-6 signal transducer, Membrane glycoprotein 130, CDw130, Oncostatin-M receptor subunit alpha |
| Ig Type | Rabbit monoclonal IgG |
| 交叉反应 | Human |
| 验证活性 | Flow cytometry analysis of IL6ST overexpressed 293F cells with TMAZ-0043, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| 应用 | ELISA, FACS, IF |
| 推荐剂量 | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Single-pass type I membrane |
| 构建方式 | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of IL6ST protein. |
| 纯化方式 | Protein A Affinity Purified |
| 性状 | Liquid |
| 缓冲液 | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| 纯度 | > 95% as determined by SDS-PAGE. |
| 研究背景 | Signal-transducing molecule (PubMed: 2261637). The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates the intracellular JAK-MAPK and JAK-STAT3 signaling pathways (PubMed: 19915009, PubMed: 2261637, PubMed: 23294003). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed: 19915009, PubMed: 23294003, PubMed: 25731159). In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop (By similarity). Also activates the yes-associated protein 1 (YAP) and NOTCH pathways to control inflammation-induced epithelial regeneration, independently of STAT3 (By similarity). Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL27RA/WSX1 and CNTFR (PubMed: 19386761). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity)|Binds to the soluble IL6: sIL6R complex (hyper-IL6), thereby blocking IL6 trans-signaling. Inhibits sIL6R-dependent acute phase response (PubMed: 11121117, PubMed: 21990364, PubMed: 30279168). Also blocks IL11 cluster signaling through IL11R (PubMed: 30279168) |
| 偶联 | Unconjugated |
| 其他可选修饰符 | Biotin/APC/PE/AF488/AF555/AF647 |
| 可提供抗体种类 | 1 |
| 免疫原 | IL6ST |
| 抗原种属 | Human |
| 基因ID | 3572 |
| Uniprot ID | |
| 研究领域 | Immunology Research |
| 分子量 | 150 kDa |
存储&运输
| 储存方式 | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| 运输方式 | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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