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Search Results for " drug-based "

Targets Recommended: Parasite

110

抑制剂 & 化合物

5

天然产物

35

化合物库

3

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name
L6900	稀有天然产物库		693 compounds
	693 种稀有天然产物的集合，可以用于高通量和高内涵筛选；
L7830	高溶解性片段药效团化合物库		985 compounds
	高溶解性片段药效团库包含985 个片段小分子。
L8800	药物片段库		1119 compounds
	1119 种药物片段分子，是FBDD 方法新药筛选的有力工具；
L6160	Ro5类药天然产物库		2703 compounds
	2703 种符合 RO5原则的天然产物单体集合，可以用于高通量和高内涵筛选；
L7800	高溶解性片段库		2728 compounds
	2728 种片段分子合集，数量适中，是 FBDD 方法新药筛选的有力工具。
LF1000	多样性核心预制库		50000 compounds
	For your convenience, there are Diversity Sets of 5,000, 10,000, 15,000, and 20,000 compounds with no structure overlap.
L1580	GPCR库Plus		338 compounds
	338 种GPCR 靶向、结构新颖的化合物；
L1500	GPCR靶点分子库		1940 compounds
	1940 种与 G 蛋白及其耦联受体相关的生物活性小分子化合物，所有小分子都具有良好的生物和药理活性，部分是 FDA 批准的上市药物；
L2151	化疗药物库		48 compounds
	48 个肿瘤化疗药物，可以用于高通量和高内涵筛选；
L1710	抗COVID-19化合物库		1133 compounds
	1133 种对SARS-CoV-2有抑制作用或潜在抑制作用的化合物集合，可用于高通量和高内涵筛选；
L1700	抗病毒库		1040 compounds
	1040 种具有抗病毒活性的化合物的特有集合，是筛选新型抗病毒药的有效工具；可用于高通量筛选和高内涵筛选；
L6810	中药单体化合物库		2755 compounds
	2755 种中药来源的单体化合物，是药物开发、药理研究等领域的有力工具；
L4600	植物来源化合物库		3048 compounds
	3048 个植物来源天然产物的独特集合，来自277类植物的精心之选；
L4020	NO PAINS 化合物库		9384 compounds
	TargetMol NO PAINS 化合物库包含 9384 个剔除了PAINS 的小分子活性化合物，可用于新药研发，信号通路研究，老药新用等研究。
L6700	抗癌天然产物库		1772 compounds
	1772 种已知活性天然产物的独特集合，是肿瘤药物开发、抗癌先导化合物筛选等领域的有力工具，可用于HTS 和HCS。
L2500	人内源代谢化合物库		499 compounds
	499 种内源性生物活性化合物的独特集合，用于高通量、高内涵筛选；
L7600	趋化因子抑制剂库		59 compounds
	59 种趋化因子或其受体抑制剂的独特集合，可用于高通量筛选和高内涵筛选；
L3600	细胞因子抑制剂库		604 compounds
	604 个与细胞因子紧密相关的化合物集合，是高通量、高内涵筛选的良好载体；
L5900	血脑屏障通透化合物库		509 compounds
	509 个 CNS-Penetrant 生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；
L5700	精选片段库		246 compounds
	246 个片段小分子的独特集合，可用于基于片段的筛选和药物发现（FBDD）；
L8000	干细胞分化化合物库		1197 compounds
	1197 种干细胞分化信号通路相关的生物活性小分子化合物的特有集合，可用于高通量、高内涵筛选；
L4500	抗真菌库		252 compounds
	252 个抗真菌活性化合物的独特集合，包含作用于真菌相关靶点的化合物和临床中用于真菌类疾病的药物，是相关疾病药物筛选的有效工具。
DO1200	药物靶点库		53200 compounds
	数量多，含53200种小分子化合物，是高通量筛选的有力工具；
L2190	抗肺癌化合物库		1702 compounds
	1702 种与肺癌相关的化合物，可以用于抗肺癌药物研发和药理研究；
L6030	天然产物衍生物虚筛化合物库		163000 compounds
	16.3万种天然产物衍生物，并且在持续增加中；
L6800	中国药典收录天然产物库		2051 compounds
	2051 种中国药典收录的天然产物，是药物开发、药理研究等领域的有力工具；
L2191	抗乳腺癌化合物库		1939 compounds
	1939 种与乳腺癌相关的化合物，可以用于抗乳腺癌药物研发和药理研究；
L2100	抗癌化合物库		7234 compounds
	7234 种肿瘤相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；
L6300	药食同源库		1290 compounds
	1290 个药食同源化合物的独特集合，可用于高通量筛选和高内涵筛选；
L6020	天然产物单体化合物库		16627 compounds
	16627 种精选天然产物集合，结构多样，遍布多种动植物与微生物；
L2170	肿瘤免疫治疗小分子化合物库		449 compounds
	449 种靶向肿瘤免疫治疗靶点的小分子，可用于高通量和高内涵筛选，是研究肿瘤免疫治疗的有力工具；
L9500	表型筛选靶点鉴定库		1796 compounds
	1796 种靶点明确的已知活性化合物，适合表型筛选；
L7110	抗高血压化合物库		678 compounds
	678 种高血压相关的小分子，用于高通量和高内涵筛选；
L7100	抗肥胖化合物库		2247 compounds
	2247 个抗肥胖化合物的独特集合，可用于高通量筛选和高内涵筛选；
L6220	蒙药化合物库		950 compounds
	950 种蒙药来源的天然产物分子集合，可以用于高通量和高内涵筛选；

化合物库

稀有天然产物库

Cat.No: L6900

Compounds: 693

高溶解性片段药效团化合物库

Cat.No: L7830

Compounds: 985

药物片段库

Cat.No: L8800

Compounds: 1119

Ro5类药天然产物库

Cat.No: L6160

Compounds: 2703

高溶解性片段库

Cat.No: L7800

Compounds: 2728

多样性核心预制库

Cat.No: LF1000

Compounds: 50000

Cat.No: L1580

Compounds: 338

GPCR靶点分子库

Cat.No: L1500

Compounds: 1940

化疗药物库

Cat.No: L2151

Compounds: 48

抗COVID-19化合物库

Cat.No: L1710

Compounds: 1133

Cat.No: L1700

Compounds: 1040

中药单体化合物库

Cat.No: L6810

Compounds: 2755

植物来源化合物库

Cat.No: L4600

Compounds: 3048

NO PAINS 化合物库

Cat.No: L4020

Compounds: 9384

抗癌天然产物库

Cat.No: L6700

Compounds: 1772

人内源代谢化合物库

Cat.No: L2500

Compounds: 499

趋化因子抑制剂库

Cat.No: L7600

Compounds: 59

细胞因子抑制剂库

Cat.No: L3600

Compounds: 604

血脑屏障通透化合物库

Cat.No: L5900

Compounds: 509

精选片段库

Cat.No: L5700

Compounds: 246

干细胞分化化合物库

Cat.No: L8000

Compounds: 1197

Cat.No: L4500

Compounds: 252

药物靶点库

Cat.No: DO1200

Compounds: 53200

抗肺癌化合物库

Cat.No: L2190

Compounds: 1702

天然产物衍生物虚筛化合物库

Cat.No: L6030

Compounds: 163000

中国药典收录天然产物库

Cat.No: L6800

Compounds: 2051

抗乳腺癌化合物库

Cat.No: L2191

Compounds: 1939

抗癌化合物库

Cat.No: L2100

Compounds: 7234

药食同源库

Cat.No: L6300

Compounds: 1290

天然产物单体化合物库

Cat.No: L6020

Compounds: 16627

肿瘤免疫治疗小分子化合物库

Cat.No: L2170

Compounds: 449

表型筛选靶点鉴定库

Cat.No: L9500

Compounds: 1796

抗高血压化合物库

Cat.No: L7110

Compounds: 678

抗肥胖化合物库

Cat.No: L7100

Compounds: 2247

蒙药化合物库

Cat.No: L6220

Compounds: 950

Cat. No.	Product Name	Target	Signaling Pathways
T7744	Piperaquine tetraphosphate tetrahydrate 4,4'-(1,3-丙烷双-4,1-哌嗪基)双(7-氯喹啉)磷酸盐水合物,四磷酸哌喹四水合物	Parasite	Microbiology/Virology
	Piperaquine tetraphosphate tetrahydrate 是一种双喹啉抗寄生虫剂，可与青蒿素联用研究抗疟。
T7532	Piperaquine	Parasite	Microbiology/Virology
	Piperaquine 是一种双喹啉化合物，可抑制来自疟疾感染患者的恶性疟原虫分离株的离体生长，IC50 范围为 11.8-217.3 nM。
T3723	Dioxopromethazine hydrochloride	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Dioxopromethazine hydrochloride 是一种基于目标的药物分类，在全球许多国家都有销售。
T0225	Pizotifen Malate Pizotyline (malate),BC-105 (malate),BC-105,苯噻啶苹果酸盐	5-HT Receptor	GPCR/G Protein; Neuroscience
	Pizotifen Malate (BC-105 malate) 是5-HT2受体的拮抗剂，对5-HT1C 有高亲和力。
T4966	Ufenamate 氟芬那酸丁酯,Flufenamic acid butyl ester,Butyl flufenamate,氟灭酸丁酯	Others	Others
	Ufenamate (Flufenamic acid butyl ester) 是一种基于邻氨基苯甲酸的抗炎药。它可用于皮肤疾病研究。
T9783	Boc-C16-COOH	PROTAC Linker; ADC Linker	Antibody-drug Conjugate/ADC Related; PROTAC
	Boc-C16-COOH 可以作为 ADC linker 或 PROTAC linker，用于合成抗体偶联药物或合成 PROTAC。
T9781	Boc-C14-COOH 十六烷基二酸单叔丁酯	PROTAC Linker; ADC Linker	Antibody-drug Conjugate/ADC Related; PROTAC
	Boc-C14-COOH 可以作为 ADC linker 或PROTAC linker，用于合成抗体偶联药物或合成 PROTAC。
T5377	Dimethyl itaconate	Others	Others
	Dimethyl itaconate 是一种化学试剂，用于合成功能化 2-异恶唑啉，用于基于片段的药物发现。
T15976	Mal-PEG1-NHS ester	Others; PROTAC Linker; ADC Linker	Antibody-drug Conjugate/ADC Related; Others; PROTAC
	Mal-PEG1-NHS ester 是一种可裂解的基于 PEG 的 ADC 接头，用于合成抗体-药物偶联物。它也是基于 PEG 的 PROTAC 接头，可用于 PROTAC 的合成。
T33604	Z-Glycine Carbobenzoxyglycine,N-苄氧羰基-甘氨酸,N-Carbobenzoxyglycine	Others	Others
	Z-Glycine (Carbobenzoxyglycine) 是一种药物-脂质结合物，旨在促进脑渗透，基于其亲脂性和与生物膜中脂质的相似性。
T9785	20-(tert-Butoxy)-20-oxoicosanoic acid	PROTAC Linker; ADC Linker	Antibody-drug Conjugate/ADC Related; PROTAC
	20-(tert-Butoxy)-20-oxoicosanoic acid 可以作为 ADC linker 或 PROTAC linker，用于合成抗体偶联药物或合成 PROTAC。
T41312	Fmoc-Lys-OH hydrochloride	PROTAC Linker; ADC Linker	Antibody-drug Conjugate/ADC Related; PROTAC
	Fmoc-Lys-OH hydrochloride 是一种基于烷基链的 PROTAC linker。 Fmoc-Lys-OH hydrochloride 是一种不可降解的 ADC linker，用于合成抗体-药物偶联物 (ADC)。
T15839	m-PEG12-amine	Others; ADC Linker	Antibody-drug Conjugate/ADC Related; Others
	m-PEG12-amine是一种基于PEG的PROTAC连接器，同时也是一种在PROTACs[1]和抗体药物偶联物(ADCs)[2]的合成中使用的不可切割的12单位PEG ADC连接器。
T14589	Biotin-PEG3-acid 18-[(3AS,4S,6AR)-六氢-2-氧代-1H-噻吩并[3,4-D]咪唑-4-基]-14-氧代-4,7,10-三氧杂-13-氮杂十八烷酸	Others; PROTAC Linker	Others; PROTAC
	Biotin-PEG3-acid 是一种属于 PEG 类的、生物素标记的 PROTAC linker，可用于 PROTAC 分子的合成。
T16218	N-Boc-PEG5-bromide	Others; PROTAC Linker; ADC Linker	Antibody-drug Conjugate/ADC Related; Others; PROTAC
	N-Boc-PEG5-bromide 是 PROTAC 的 linker，属于 PEG 类和 Alkyl/ether 类.它也是可降解的 ADC 连接桥，用于抗体药物结合物的合成。
FL0195	N-Boc-4-hydroxy-L-proline methyl ester	Others; ADC Linker	Antibody-drug Conjugate/ADC Related; Others
	N-Boc-cis-4-hydroxy-L-proline methyl ester为不可降解(non-cleavable)的ADC linker，用于抗体药物偶联体(ADCs)合成。该化合物同时作为基于烷基链(alkyl chain)的PROTAC linker，适用于PROTAC合成。
T16315	NH2-PEG6-Boc 氨基-五聚乙二醇-丙酸叔丁酯	PROTAC Linker; ADC Linker	Antibody-drug Conjugate/ADC Related; PROTAC
	NH2-PEG6-Boc 是一种基于 PEG 的 PROTAC 接头，可用于 PROTAC 的合成。它也是一种不可切割的 6 单元 PEG ADC 接头，用于合成抗体-药物偶联物。
T15304	Fmoc-8-amino-3,6-dioxaoctanoic acid Fmoc-NH-PEG2-CH2COOH,[2-[2-(Fmoc-氨基)乙氧基]乙氧基]乙酸	PROTAC Linker; ADC Linker	Antibody-drug Conjugate/ADC Related; PROTAC
	Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) 是一种可裂解的 ADC 连接剂，用于合成抗体-药物偶联物。它也是一种基于 PEG 的 PROTAC 接头，可用于 PROTAC 的合成。
T4630	NSC 404988	Others	Others
	NSC 404988 是一种苯甲酰胺类生物活性化合物，用于化合物的合成和药物的制备，还被用于药物代谢的研究和生物系统中代谢物的分析。
T8488	GMB-475	Bcr-Abl; PROTACs	Angiogenesis; Cytoskeletal Signaling; PROTAC; Tyrosine Kinase/Adaptors
	GMB-475 是一种基于PROTAC 的BCR-ABL1酪氨酸激酶降解剂，克服了BCR-ABL1依赖的耐药性。 GMB-475 靶向 BCR-ABL1 蛋白并募集 E3 连接酶 Von Hippel Lindau (VHL)。导致泛素化和随后的致癌融合蛋白降解
T18143	m-PEG12-OH Dodecaethylene Glycol Monomethyl Ether	Others; PROTAC Linker; ADC Linker	Antibody-drug Conjugate/ADC Related; Others; PROTAC
	m-PEG12-OH (Dodecaethylene Glycol Monomethyl Ether) 是一种基于 PEG 的 PROTAC 接头，可用于 PROTAC 的合成。它也是一种不可切割的 12 单元 PEG ADC 接头，用于合成抗体-药物偶联物。
T9019	JHU37152 JHU 37152	AChR	Neuroscience
	JHU37152 (JHU 37152) 是一种可透过血脑屏障的DREADD 激动剂。在 HEK-293 细胞的荧光和基于 BRET 的测定中，对hM3Dq 和hM4Di DREADDs 的EC50值分别为 5 和 0.5 nM。
T9018	JHU37160 JHU 37160	AChR	Neuroscience
	JHU37160 (JHU 37160) 是一种可透过血脑屏障的 DREADD 激动剂。在 HEK-293 细胞的荧光和基于 BRET 的测定中，对hM3Dq 和hM4Di DREADDs 的EC50值分别为 18.5 和 0.2 nM。
T0910	Terpin hydrate Terpin Monohydrate,cis-Terpin hydrate,萜品(水合结晶)	Others	Others
	Terpin hydrate 是一种祛痰药，可除去急慢性支气管炎病人的黏液。
T35841	5-Benzyloxygramine	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	5-Benzyloxygramine 是一种 N 蛋白、蛋白互作的原位稳定剂，具有抗病毒和稳定 N-NTD 蛋白的作用。它能够阻断多巴胺受体，可拮抗 5-HT 对大鼠子宫和兔耳的作用。
T18701	SPDB-DM4	Others; Drug-Linker Conjugates for ADC	Antibody-drug Conjugate/ADC Related; Others
	SPDB-DM4 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications, employing the maytansine-based payload DM4 (a tubulin inhibitor) connected through a SPDB linker. This compound demonstrates significant anti-tumor efficacy.
T28011	Megazol CL 64855,CL-64855,CL64855	Others	Others
	Megazol is a nitroimidazole based drug that cures some protozoan infections. A study of nitroimidazoles found the drug extremely effective against T. cruzi and T. brucei which cause Chagas disease and African sleeping sickness, respectively.
T18730	sulfo-SPDB-DM4	Others; Drug-Linker Conjugates for ADC	Antibody-drug Conjugate/ADC Related; Others
	Sulfo-SPDB-DM4 is a drug-linker conjugate designed for antibody-drug conjugates (ADCs) that employs the maytansine-based payload (DM4, an antitubulin agent) connected through the sulfo-SPDB linker.
T11119	Duocarmycin DM free base Duocarmycin	Others; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Others
	Duocarmycin is a DNA minor groove binding alkylating agent and explored as drug–antibody conjugates (ADCs) . Duocarmycin is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity.
T14241	Amino-PEG4-CH2COOH	Others; ADC Linker	Antibody-drug Conjugate/ADC Related; Others
	Amino-PEG4-CH2COOH is a PEG-based PROTAC linker and a non-cleavable 4 unit PEG ADC linker employed in the synthesis of PROTACs and antibody-drug conjugates (ADCs).
T12776	RT-AM	Others	Others
	RT-AM is a pro-drug real thiol. Real Thiol is a reversible reaction-based fluorescent probe.
T15763	Lipoamido-PEG3-OH	Others	Others
	Lipoamido-PEG3-OH, also known as compound TA-TEG-G2CN, is a PEG-based PROTAC linker utilized in PROTAC synthesis. It is instrumental in the creation of a robust, dendronized gold nanoparticle (AuNP)-based drug delivery platform[1].
T38618	Mal-CO-PEG5-NHS ester Mal-CO-PEG5-NHS ester	Others; ADC Linker	Antibody-drug Conjugate/ADC Related; Others
	Mal-CO-PEG5-NHS ester is a 5-unit PEG-based, non-cleavable ADC linker utilized in the fabrication of antibody-drug conjugates (ADCs).
T17448	AmPEG6C2-Aur0131	Others; Drug-Linker Conjugates for ADC	Antibody-drug Conjugate/ADC Related; Others
	AmPEG6C2-Aur0131 is a drug-linker conjugate designed for anti-CXCR4 ADC applications, showcasing potent antitumor activity. It incorporates Aur0131, an auristatin-based microtubule inhibitor, connected through the non-cleavable AmPEG6C2 linker.
T18871	VCP-Eribulin	Others; Drug-Linker Conjugates for ADC	Antibody-drug Conjugate/ADC Related; Others
	VCP-Eribulin, an Eribulin-based drug for antibody conjugates[1], combines the VCP (ADCs linker) with Eribulin, a distinct microtubule inhibitor used in cancer treatments[2].
T16635	Propargyl-PEG4-Tos	Others; ADC Linker	Antibody-drug Conjugate/ADC Related; Others
	Propargyl-PEG4-Tos is a PEG-based PROTAC linker utilized for the synthesis of PROTACs and cleavable ADC linkers in antibody-drug conjugate (ADC) synthesis [1][2].
T74234	Linoleyl methane sulfonate	Others	Others
	Linoleyl methane sulfonate 可作为选择性的脂质载体，用于药物递送系统。
T14445	Azido-PEG4-C2-acid	Others; ADC Linker	Antibody-drug Conjugate/ADC Related; Others
	Azido-PEG4-C2-acid, a PEG-based PROTAC linker, is utilized in the synthesis of vRucaparib-TP4. It serves as a non-cleavable 4 unit PEG ADC linker for antibody-drug conjugate (ADC) synthesis.
T14256	Amino-Tri-(carboxyethoxymethyl)-methane	Others; ADC Linker	Antibody-drug Conjugate/ADC Related; Others
	Amino-Tri-(carboxyethoxymethyl)-methane, an ADC linker and PROTAC linker, is a cleavable PEG compound utilized for the synthesis of antibody-drug conjugates (ADCs)[1] and PEG-based PROTACs[2].
T16598	Propargyl-PEG2-amine 2-(2-(丙-2-炔-1-基氧基)乙氧基)乙胺	Others; ADC Linker	Antibody-drug Conjugate/ADC Related; Others
	Propargyl-PEG2-amine is a non-cleavable ADC linker employed for synthesizing antibody-drug conjugates (ADCs). It is a PEG-based PROTAC linker that finds applications in PROTAC synthesis [1][2].
T14726	Boc-gly-PEG3-endo-BCN	Others; ADC Linker	Antibody-drug Conjugate/ADC Related; Others
	Boc-gly-PEG3-endo-BCN is a PEG-based PROTAC linker and a cleavable 2-unit PEG ADC linker, utilized in the synthesis of PROTACs[1] and antibody-drug conjugates (ADCs)[2], respectively.
T15953	Mal-amido-PEG2-Val-Cit-PAB-PNP	Others; ADC Linker	Antibody-drug Conjugate/ADC Related; Others
	Mal-amido-PEG2-Val-Cit-PAB-PNP is a cleavable 2-unit polyethylene glycol (PEG) based ADC linker utilized in the construction of antibody-drug conjugates (ADCs)[1].
T14394	Azide-PEG3-Tos	Others; ADC Linker	Antibody-drug Conjugate/ADC Related; Others
	Azide-PEG3-Tos is a PEG-based PROTAC linker utilized in the synthesis of PROTACs[1]. It is a non-cleavable 3 unit PEG ADC linker employed in the synthesis of antibody-drug conjugates (ADCs)[2].
T17084	THP-PEG6-OH	Others; ADC Linker	Antibody-drug Conjugate/ADC Related; Others
	THP-PEG6-OH is a polyethylene glycol (PEG)-based PROTAC linker, utilized in the synthesis of PROTACs[1]. It is also a non-cleavable three-unit PEG linker for antibody-drug conjugates (ADCs)[2].
T14006	Boc-NH-PEG4-CH2CH2COOH	Others; ADC Linker	Antibody-drug Conjugate/ADC Related; Others
	Boc-NH-PEG4-CH2CH2COOH is a PEG-based PROTAC linker employed in the synthesis of PROTAC[1]. Additionally, it is utilized as a cleavable ADC linker for antibody-drug conjugates (ADC)[2].
T17055	Tetraethylene glycol monotosylate Tos-PEG4	Others; ADC Linker	Antibody-drug Conjugate/ADC Related; Others
	Tetraethylene glycol monotosylate is a cleavable and acylhydrazone-based ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
T68849	Cilobamine (free base)	Others	Others
	Cilobamine (free base) is a drug which acts as a norepinephrine-dopamine reuptake inhibitor and has stimulant and antidepressant effects. It can clearly be seen that the structure is based on dichloroisoprenaline that has been fused onto the bicycloalkane scaffold.
T14237	Amino-PEG4-alcohol	Others; ADC Linker	Antibody-drug Conjugate/ADC Related; Others
	Amino-PEG4-alcohol is a PEG-based PROTAC linker that can be employed for the synthesis of PROTACs[1]. It is also a non-cleavable 4 unit PEG ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs)[2].
T16314	NH2-PEG5-OH	Others; ADC Linker	Antibody-drug Conjugate/ADC Related; Others
	NH2-PEG5-OH is a polyethylene glycol (PEG)-based PROTAC linker, utilized for the synthesis of PROTACs[1]. It is a 5-unit PEG ADC linker that is non-cleavable, and employed in the synthesis of antibody-drug conjugates (ADCs)[2].
T17531	BCN-PEG3-Val-Cit	Others	Others
	BCN-PEG3-Val-Cit is a PEG-based linker commonly employed in PROTAC synthesis[1]. Additionally, it serves as a cleavable 3 unit PEG linker in the production of antibody-drug conjugates (ADCs)[2].

化合物

Piperaquine tetraphosphate tetrahydrate

Cat.No: T7744

Synonym: 4,4'-(1,3-丙烷双-4,1-哌嗪基)双(7-氯喹啉)磷酸盐水合物,四磷酸哌喹四水合物

Target: Parasite

Cat.No: T7532

Target: Parasite

Dioxopromethazine hydrochloride

Cat.No: T3723

Target: Histamine Receptor

Pizotifen Malate

Cat.No: T0225

Synonym: Pizotyline (malate),BC-105 (malate),BC-105,苯噻啶苹果酸盐

Target: 5-HT Receptor

Cat.No: T4966

Synonym: 氟芬那酸丁酯,Flufenamic acid butyl ester,Butyl flufenamate,氟灭酸丁酯

Target: Others

Cat.No: T9783

Target: PROTAC Linker, ADC Linker

Cat.No: T9781

Synonym: 十六烷基二酸单叔丁酯

Target: PROTAC Linker, ADC Linker

Dimethyl itaconate

Cat.No: T5377

Target: Others

Mal-PEG1-NHS ester

Cat.No: T15976

Target: Others, PROTAC Linker, ADC Linker

Cat.No: T33604

Synonym: Carbobenzoxyglycine,N-苄氧羰基-甘氨酸,N-Carbobenzoxyglycine

Target: Others

20-(tert-Butoxy)-20-oxoicosanoic acid

Cat.No: T9785

Target: PROTAC Linker, ADC Linker

Fmoc-Lys-OH hydrochloride

Cat.No: T41312

Target: PROTAC Linker, ADC Linker

Cat.No: T15839

Target: Others, ADC Linker

Biotin-PEG3-acid

Cat.No: T14589

Synonym: 18-[(3AS,4S,6AR)-六氢-2-氧代-1H-噻吩并[3,4-D]咪唑-4-基]-14-氧代-4,7,10-三氧杂-13-氮杂十八烷酸

Target: Others, PROTAC Linker

N-Boc-PEG5-bromide

Cat.No: T16218

Target: Others, PROTAC Linker, ADC Linker

N-Boc-4-hydroxy-L-proline methyl ester

Cat.No: FL0195

Target: Others, ADC Linker

Cat.No: T16315

Synonym: 氨基-五聚乙二醇-丙酸叔丁酯

Target: PROTAC Linker, ADC Linker

Fmoc-8-amino-3,6-dioxaoctanoic acid

Cat.No: T15304

Synonym: Fmoc-NH-PEG2-CH2COOH,[2-[2-(Fmoc-氨基)乙氧基]乙氧基]乙酸

Target: PROTAC Linker, ADC Linker

Cat.No: T4630

Target: Others

Cat.No: T8488

Target: Bcr-Abl, PROTACs

Cat.No: T18143

Synonym: Dodecaethylene Glycol Monomethyl Ether

Target: Others, PROTAC Linker, ADC Linker

Cat.No: T9019

Synonym: JHU 37152

Target: AChR

Cat.No: T9018

Synonym: JHU 37160

Target: AChR

Cat.No: T0910

Synonym: Terpin Monohydrate,cis-Terpin hydrate,萜品(水合结晶)

Target: Others

5-Benzyloxygramine

Cat.No: T35841

Target: Dopamine Receptor, 5-HT Receptor

Cat.No: T18701

Target: Others, Drug-Linker Conjugates for ADC

Cat.No: T28011

Synonym: CL 64855,CL-64855,CL64855

Target: Others

Cat.No: T18730

Target: Others, Drug-Linker Conjugates for ADC

Duocarmycin DM free base

Cat.No: T11119

Synonym: Duocarmycin

Target: Others, ADC Cytotoxin

Amino-PEG4-CH2COOH

Cat.No: T14241

Target: Others, ADC Linker

Cat.No: T12776

Target: Others

Lipoamido-PEG3-OH

Cat.No: T15763

Target: Others

Mal-CO-PEG5-NHS ester

Cat.No: T38618

Synonym: Mal-CO-PEG5-NHS ester

Target: Others, ADC Linker

AmPEG6C2-Aur0131

Cat.No: T17448

Target: Others, Drug-Linker Conjugates for ADC

Cat.No: T18871

Target: Others, Drug-Linker Conjugates for ADC

Propargyl-PEG4-Tos

Cat.No: T16635

Target: Others, ADC Linker

Linoleyl methane sulfonate

Cat.No: T74234

Target: Others

Azido-PEG4-C2-acid

Cat.No: T14445

Target: Others, ADC Linker

Amino-Tri-(carboxyethoxymethyl)-methane

Cat.No: T14256

Target: Others, ADC Linker

Propargyl-PEG2-amine

Cat.No: T16598

Synonym: 2-(2-(丙-2-炔-1-基氧基)乙氧基)乙胺

Target: Others, ADC Linker

Boc-gly-PEG3-endo-BCN

Cat.No: T14726

Target: Others, ADC Linker

Mal-amido-PEG2-Val-Cit-PAB-PNP

Cat.No: T15953

Target: Others, ADC Linker

Cat.No: T14394

Target: Others, ADC Linker

Cat.No: T17084

Target: Others, ADC Linker

Boc-NH-PEG4-CH2CH2COOH

Cat.No: T14006

Target: Others, ADC Linker

Tetraethylene glycol monotosylate

Cat.No: T17055

Synonym: Tos-PEG4

Target: Others, ADC Linker

Cilobamine (free base)

Cat.No: T68849

Target: Others

Amino-PEG4-alcohol

Cat.No: T14237

Target: Others, ADC Linker

Cat.No: T16314

Target: Others, ADC Linker

BCN-PEG3-Val-Cit

Cat.No: T17531

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T9784	Docosanedioic acid	PROTAC Linker; ADC Linker	Antibody-drug Conjugate/ADC Related; PROTAC
	Docosanedioic acid 可以作为ADC linker 或PROTAC linker，用于合成抗体偶联药物或合成 PROTAC。
T5S2361	Epiberberine	ERK; Beta-Secretase; MEK; BACE; AMPK; AChR; AChE	Chromatin/Epigenetic; MAPK; Neuroscience; PI3K/Akt/mTOR signaling
	Epiberberine 是一种从黄连中得到的生物碱，是AChE 和BChE 抑制剂，和非竞争性BACE1抑制剂。在 3T3-L1 细胞分化早期，它能够下调 Raf/MEK1/2/ERK1/2 和 AMPKα/Akt 信号通路。它具有抗氧化作用，能够清除 ONOO-，可用于阿尔滋海默症和糖尿病的研究。
T5S0053	Coptisine 黄连碱,Coptisin	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Coptisine (Coptisin) 是一种从黄连中分离到的生物碱，是非竞争性的IDO 抑制剂，Ki=为 5.8 μM，IC50=6.3 μM。
T0256	Citric acid trilithium salt tetrahydrate Lithium citrate tribasic tetrahydrate,柠檬酸三锂盐四水合物,Trilithium citrate tetrahydrate	Dehydrogenase; GSK-3; HIF/HIF Prolyl-Hydroxylase; Antibacterial; GluR	Chromatin/Epigenetic; Metabolism; Microbiology/Virology; Neuroscience; PI3K/Akt/mTOR signaling; Stem Cells
	Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) 是一种用于治疗精神疾病的药物。它也是一种医药和建筑材料, 可用于氨基酸定量分析时的梯度洗脱。
T4439	sn-Glycero-3-phosphocholine Choline Alfoscerate,甘磷酸胆碱,Glycerophosphocholine,Glycerophosphorylcholine,Alpha-GPC,Choline glycerophosphate,L-α-GPC	Endogenous Metabolite; AChE	Metabolism; Neuroscience
	sn-Glycero-3-phosphocholine (Choline glycerophosphate) 是脑磷脂生物合成的前体，能够提高胆碱在神经组织中的生物利用度。它对认知功能有显著影响，同时具有良好的耐受性和安全性，因此能够用于阿尔茨海默病和痴呆症的研究。

天然产物

Docosanedioic acid

Cat.No: T9784

Target: PROTAC Linker, ADC Linker

Cat.No: T5S2361

Target: ERK, Beta-Secretase, MEK, BACE, AMPK, AChR, AChE

Cat.No: T5S0053

Synonym: 黄连碱,Coptisin

Target: Indoleamine 2,3-Dioxygenase (IDO)

Citric acid trilithium salt tetrahydrate

Cat.No: T0256

Synonym: Lithium citrate tribasic tetrahydrate,柠檬酸三锂盐四水合物,Trilithium citrate tetrahydrate

Target: Dehydrogenase, GSK-3, HIF/HIF Prolyl-Hydroxylase, Antibacterial, GluR

sn-Glycero-3-phosphocholine

Cat.No: T4439

Synonym: Choline Alfoscerate,甘磷酸胆碱,Glycerophosphocholine,Glycerophosphorylcholine,Alpha-GPC,Choline glycerophosphate,L-α-GPC

Target: Endogenous Metabolite, AChE

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00806	GHR/Growth Hormone R Protein, Human, Recombinant (His) GHR/BP,GH receptor,GHBP,GHR	Human	HEK293 Cells
	Pegvisomant, a growth hormone receptor (GHR) antagonist, is a well-known drug that was designed to treat acromegaly. However, recent studies have indicated that the GHR is a "moonlighting" protein that may exhibit dual functions based on its localization in the plasma membrane and nucleus.
TMPK-01158	Kallikrein 5/KLK5 Protein, Mouse, Recombinant (His) SCTE,KLKL2,KLK5,KLK-L2,Klnc,Kallikrein c	Mouse	HEK293 Cells
	The inhibition of kallikrein 5 (KLK5) has been identified as a potential strategy for treatment of the genetic skin disorder Netherton syndrome, in which loss-of-function mutations in the SPINK5 gene lead to down-regulation of the endogenous inhibitor LEKTI-1 and profound skin-barrier defects with severe allergic manifestations. To aid in the development of a medicine for this target, an X-ray crystallographic system was developed to facilitate fragment-guided chemistry and knowledge-based drug-...
TMPJ-00922	DCK Protein, Human, Recombinant (His & T7) DCK,Deoxycytidine Kinase	Human	E. coli
	Deoxycytidine Kinase (DCK) is a member of the DCK/DGK family. DCK exists as a homodimer and is localized to the nucleus. DCK is required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG), and deoxyadenosine (dA). DCK has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. In addition, DCK is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and c...

重组蛋白

GHR/Growth Hormone R Protein, Human, Recombinant (His)

Cat.No: TMPK-00806

Species: Human

Expression System: HEK293 Cells

Kallikrein 5/KLK5 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01158

Species: Mouse

Expression System: HEK293 Cells

DCK Protein, Human, Recombinant (His & T7)

Cat.No: TMPJ-00922

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0079	N-Carbobenzyloxyglycine-d2
	N-Carbobenzyloxyglycine-d2 是 N-Carbobenzyloxyglycine 的氘代化合物。N-Carbobenzyloxyglycine 的 CAS 号为 1138-80-3。Z-Glycine (Carbobenzoxyglycine) 是一种药物-脂质结合物，旨在促进脑渗透，基于其亲脂性和与生物膜中脂质的相似性。
T71212	Lornoxicam-d4
	Lornoxicam-d4 is intended for use as an internal standard for the quantification of lornoxicam by GC- or LC-MS. Lornoxicam is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. It inhibits production of thromboxane B2 from arachidonic acid in HEL human erythroleukemic cells, which endogenously express COX-1, as well as inhibits LPS-induced formation of prostaglandin F1α from arachidonic acid in Mono-Mac-6 cells, which endogenously e...

同位素标记化合物

N-Carbobenzyloxyglycine-d2

Cat.No: TMIJ-0079

Cat.No: T71212

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