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Search Results for " cytokines "
Targets Recommended: Others

118

抑制剂 & 化合物

57

天然产物

8

化合物库

136

重组蛋白

2

同位素标记化合物

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Cat. No. Product Name
L3600 细胞因子抑制剂库

604 compounds
604 个与细胞因子紧密相关的化合物集合,是高通量、高内涵筛选的良好载体;
L1400 MAPK 抑制剂库

365 compounds
365 种与MAPK 信号通路相关的生物活性小分子化合物的特有集合,可用于高通量筛选和高内涵筛选;
L8000 干细胞分化化合物库

1197 compounds
1197 种干细胞分化信号通路相关的生物活性小分子化合物的特有集合,可用于高通量、高内涵筛选;
L7900 成骨分子库

317 compounds
317 种成骨相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选;
L2500 人内源代谢化合物库

499 compounds
499 种内源性生物活性化合物的独特集合,用于高通量、高内涵筛选;
L6140 糖类及苷类化合物库

595 compounds
595 种糖类或苷类的化合物,可用于高通量筛选和高内涵筛选;
L6120 黄酮类天然产物库

514 compounds
514 种黄酮类天然产物的独特集合,可用于高通量筛选和高内涵筛选;
L9420 外泌体相关化合物库

76 compounds
76 种外泌体相关的化合物,可以用于高通量和高内涵筛选;

化合物库

细胞因子抑制剂库
Cat.No: L3600
Compounds: 604
MAPK 抑制剂库
Cat.No: L1400
Compounds: 365
干细胞分化化合物库
Cat.No: L8000
Compounds: 1197
成骨分子库
Cat.No: L7900
Compounds: 317
人内源代谢化合物库
Cat.No: L2500
Compounds: 499
糖类及苷类化合物库
Cat.No: L6140
Compounds: 595
黄酮类天然产物库
Cat.No: L6120
Compounds: 514
外泌体相关化合物库
Cat.No: L9420
Compounds: 76
Cat. No. Product Name Target Signaling Pathways
T21729 (±)-Lisofylline

Others Others
(±)-Lisofylline 是一种对映异构体特异性、烷基取代的甲基黄嘌呤,在下调白细胞活化方面具有特异性和有效的活性。它是一种抗炎剂。
T38361 GSK717

IL Receptor; NOD Immunology/Inflammation; NF-κB
GSK717 是 NOD2(核苷酸结合寡聚结构域 2) 的选择性抑制剂。它抑制壁酰二肽 (MDP) 诱导的 NOD2 介导的信号转导,抑制 MDP 刺激的 HEK293/hNOD2 细胞分泌 IL-8 (IC50为 400 nM)。
T8233 BRD3308

Apoptosis; HIV Protease; HDAC Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
BRD3308 是一种高选择性的HDAC3抑制剂,IC50为 54 nM。它可激活HIV-1转录并破坏HIV-1潜伏期。它抑制由炎性细胞因子或糖脂毒性应激诱导的胰腺 β 细胞凋亡,并增加功能性胰岛素释放。
T6716 Valsartan

Diovan,缬沙坦,Tareg,CGP 48933

RAAS Endocrinology/Hormones
Valsartan (CGP 48933) 是一种血管紧张素 II 受体拮抗剂,有用于高血压和心力衰竭的研究潜力。
T2036 6-OAU

GTPL5846

GPR Endocrinology/Hormones; GPCR/G Protein
6-OAU (GTPL5846) 是 GPR84 的替代激动剂,在 Gqi5 嵌合体存在的情况下,在 HEK293 细胞中激活人 GPR84,在 PI 测定中 EC50 为 105 nM。
T0446 Naphazoline hydrochloride

盐酸萘甲唑啉,Albalon,Rhinantin,Naphazoline HCl

Adrenergic Receptor GPCR/G Protein; Neuroscience
Naphazoline hydrochloride (Naphazoline HCl) 是一种咪唑啉衍生物,是一种眼血管收缩剂。
T21445 Naphazoline

AK-Con,Naphcon-a,Clear Eyes,All Clear,萘甲唑林

Adrenergic Receptor GPCR/G Protein; Neuroscience
Naphazoline (Naphcon-a) 是一种具有显着 α 肾上腺素能活性的拟交感神经化合物。 萘甲唑啉可用作血管收缩剂,当应用于粘膜时可快速减少肿胀。
T38423 CL097

CL097

Reactive Oxygen Species; TLR Immunology/Inflammation; Metabolism; NF-κB
CL097 是 TLR7 和 TLR8 的有效激动剂。 CL097 诱导巨噬细胞中的促炎细胞因子和 NADPH 氧化酶引发,从而增加 fMLF 刺激的 ROS 产生。
T4982 Benznidazol

苄哒唑,苄硝唑,Radanil,Benznidazole,Ro 71051,Ro 07-1051

Antibiotic; Parasite Microbiology/Virology
Benznidazol (Benznidazole) 是一种抗寄生虫药物,对哥伦比亚 T. cruzi 菌株的 IC50值为 20.35 μM,有潜力研究美洲锥虫病。
T27034 CL075

3M002,CL-075

NF-κB; TLR; MyD88 Immunology/Inflammation; NF-κB
CL075 (3M002) 是一种选择性TLR8 激动剂。CL075具有免疫调节活性,通过触发 MyD88 依赖性信号通路,激活 NF-κB 和 IRF7 引发炎症性细胞因子和 I 型干扰素 (IFN) 的产生。
T15689 L-798106

L 798106,CM9,GW-671021,CM-9,GW671021

Prostaglandin Receptor GPCR/G Protein; Immunology/Inflammation
L-798106 (CM9) 是一种具有选择性和高效性的前列腺素类 EP3 受体拮抗剂 ,抑制 EP4,EP1 和 EP2 受体,抑制动脉粥样硬化中促炎细胞因子的水平,可减弱 PGE2 诱导的咳嗽。
T30231 AVP-13358

Others Others
AVP-13358是一种CD23拮抗剂(免疫球蛋白ε-Fc 受体拮抗剂),一种免疫球蛋白E 抑制剂。AVP-13358对IgE、细胞因子和CD23有强效活性 ,可用于治疗免疫系统疾病、感染和耳鼻喉科疾病。
T17107 TMC353121

IL Receptor; TNF; RSV Apoptosis; Immunology/Inflammation; Microbiology/Virology
TMC353121 是呼吸道合胞病毒 (RSV) 融合抑制剂,具有抗 RSV 活性,抑制炎性细胞因子 TNF-α、IL-6 和 IL-1β 以及趋化因子、KC、IP-10、MCP 和 MIP1-α 的产生。
T6964 Resiquimod

R848,雷西莫特,S28463

HCV Protease; TLR Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
Resiquimod (R848) 是一种 Toll 样受体7/8的激动剂,可诱导细胞因子上调。
T20763 Betamethasone disodium phosphate

Vista-Methasone,NSC90616,Betamethasone 21-phosphate disodium salt,NSC-90616

Others Others
Betamethasone disodium phosphate (Betamethasone 21-phosphate disodium salt) 是一种具有抗炎活性的皮质类固醇,通过减少促炎细胞因子的分泌促进 M1 至 M2 巨噬细胞极化,可用于研究瘢痕疙瘩和类风湿性关节炎。
T6914 Oclacitinib maleate

PF-03394197 maleate,奥拉替尼马来酸盐,PF-03394197

Tyrosine Kinases; JAK Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
Oclacitinib maleate (PF-03394197 maleate) 是一种新型JAK 抑制剂,有效抑制JAK1,IC50为 10 nM。
T7872 Monolaurin

Others Others
Monolaurin 是椰子油中的一种表面活性剂和乳化剂。它抑制葡萄球菌、链球菌、加德纳菌、念珠菌和嗜血杆菌的生长,并减少促炎细胞因子的产生。
T15096 Delgocitinib

JTE-052,迪高替尼,Corectim(Delgocitinib)

Tyrosine Kinases; JAK Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
Delgocitinib(JTE-052)是一种特异性的JAK(Janus激酶)抑制剂,其对JAK1、JAK2、JAK3 和 Tyk2 的 IC50 值分别为 2.8、2.6、13 和 58 nM。Delgocitinib 通过JAK-依赖性细胞因子参与多种炎症和自身免疫性疾病,能有效地遏制多种细胞因子信号传递,同时抑制了因细胞因子而引发的瘙痒。它可广泛用于治疗各种炎症性疾病,包括自身免疫性疾病和超敏反应。
T9543 Syk Inhibitor II hydrochloride

Others Others
Syk Inhibitor II hydrochloride 信号传导的影响在狼疮中可能很突出。
T33535 MW01-2-151SRM

MW 151,MW-151,MW012151SRM,MW151,MW01 2 151SRM

Others Others
MW01-2-151SRM 是一种新型可穿过血脑屏障的小分子小胶质细胞活化抑制剂,具有抗神经炎作用,可减弱神经炎症模型中的神经胶质细胞因子上调,可用研究创伤性脑损伤、阿尔茨海默病和海藻氨酸毒性。
T2401 Alogliptin Benzoate

苯甲酸阿格列汀,SYR 322,Alogliptin(SYR-322)benzoate

Ferroptosis; Proteasome; DPP-4 Apoptosis; Proteases/Proteasome; Ubiquitination
Alogliptin Benzoate (SYR 322) 是一种有效且特异性的 DPP-4 抑制剂 ,IC50值小于 10 nM,其选择性比 DPP-8/9 高 10,000 倍以上,可用于研究 2 型糖尿病。
T6273 Vadimezan

DMXAA,伐地美生,5,6-Dimethylxanthenone-4-acetic Acid,NSC 640488,ASA-404

Influenza Virus; VDA; STING; IFNAR Angiogenesis; Immunology/Inflammation; Microbiology/Virology
Vadimezan (DMXAA) 是一种血管破坏剂,一种鼠 STING 激动剂,也是一种细胞因子如 I 型 IFN 的诱导剂。Vadimezan 具有抗肿瘤活性,可以诱导肿瘤中的血流快速停止,但不影响正常组织中的血流。
T36310 AKT-IN-6

INCB-047775

Akt Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
AKT-IN-6 (INCB-047775)对ATK 有抑制作用。Akt 是对生长因子、细胞因子和其他细胞刺激的细胞信号传导的重要组成部分。Akt 的异常激活与2型糖尿病和癌症的发生密切相关。
T79600 Zharp2-1

RIP kinase Apoptosis; NF-κB
Zharp2-1是一种 RIPK2 抑制剂,抑制了 MDP 诱导或单核细胞增生李斯特菌感染诱导的炎症细胞因子的转录,缓解MDP诱导的小鼠腹膜炎症状,可用于研究炎症性肠病 (IBD)。
T0468 Lidocaine

Lignocaine,Alphacaine,Xylocaine,利多卡因

Apoptosis; ERK; NF-κB; MEK; Sodium Channel; Histamine Receptor Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK; Membrane transporter/Ion channel; Neuroscience; NF-κB
Lidocaine (Alphacaine) 是一种酰胺衍生物,抑制涉及复杂电压和依赖性的钠通道,可用于研究室性心律失常。它通过调节 miR-145 表达和进一步抑制 MEK/ERK 和 NF-κB 信号通路来减少胃癌细胞的生长,迁移和侵袭。
T67896 CB2R/FAAH modulator-1

Cannabinoid Receptor; FAAH GPCR/G Protein; Metabolism; Neuroscience
CB2R/FAAH modulator-1是一种大麻素2型受体(CB2R)激动剂,同时也是脂肪酸酰胺水解酶(FAAH)抑制剂(IC50=4 μM),可减少促炎和增加抗炎细胞因子的产生,常用于炎症研究。对 CB2R 和 CB1R 的Kis 分别为14.8 nM 和241.3 nM。
TP1592L C-Reactive Protein (CRP) 174-185 acetate

C-Reactive Protein (CRP) 174-185 acetate(160369-86-8 free base)

Others Others
C-Reactive Protein (CRP) 174-185 acetate(160369-86-8 free base) 是一种急性期血清蛋白,可响应炎性细胞因子而合成,在动物中产生抗肿瘤作用。片段 CRP (174-185) (RS-83277) 通过显着增强体外人单核细胞和肺泡巨噬细胞的杀肿瘤活性显示出相似的活性。
T38362 Guselkumab

CNTO 1959

IL Receptor Immunology/Inflammation
Guselkumab (CNTO 1959) 是一种针对IL-23p19亚基的重组人IgG1单克隆抗体。Guselkumab 与人和食蟹猴IL-23结合,Kd 值分别为3.3和1.9 pmol/L。Guselkumab 对IL-23信号通路下游细胞因子的产生具有抑制作用,可用于银屑病关节炎的研究。
T76781 Itolizumab

EQ-001

Others Others
Itolizumab (Anti-Human CD6 Recombinant Antibody) 是一种人源化针对 CD6 的细胞外 SRCR 远端结构域 1的重组 抗 CD6 单克隆抗体。Itolizumab 可减缓 T 细胞增殖并抑制促炎细胞因子的产生。Itolizumab 可用于研究银屑病、类风湿性关节炎 (RA)和 COVID-19 疾病等多种疾病。
T12848 SB-657510

Others; Neurotensin Receptor GPCR/G Protein; Others
SB-657510 是 urotensin II (UII) receptor (UT) 拮抗剂。 对于人,猴,猫,大鼠和小鼠的UT 的 Ki 值分别为 61、17、30、65 和 56 nM。SB-657510 通过抑制 UII 诱导的人类血管内皮细胞中炎性介质,如粘附分子,使细胞因子和组织因子上调从而发挥抗炎作用。SB 657510对糖尿病小鼠模型中糖尿病相关动脉粥样硬化疾病具有治疗作用。
T15017 CU-T12-9

TLR Immunology/Inflammation
CU-T12-9 是特异性 TLR1/2激动剂,可激活先天免疫系统和适应性免疫系统。它选择性激活 TLR1/2 异二聚体,可通过促进 TLR1 和 TLR2 二聚而激活 NF-κB 信号,引起下游 TNF-α、IL-10 和 iNOS 增加。
T67924 ABzOH

Others Others
ABzOH 是一种苯甲酸衍生物,结构类似于阿司匹林等非甾体抗炎药,具有抗炎、抗肿瘤和抗增殖作用。ABzOH 不仅可以抑制肿瘤坏死因子- α (TNF-a)、白细胞介素-1β (IL-1β)和白细胞介素-6 (IL-6)等促炎细胞因子的表达还对乳腺癌、肺癌和胰腺癌具有抑制作用。
T61025 GSK-1482160

P2X Receptor Membrane transporter/Ion channel; Neuroscience
GSK-1482160是一种CNS-渗透的P2X7受体负变构调节剂,具有口服活性。P2X7受体参与中枢和外周免疫细胞产生促炎细胞因子,因此GSK-1482160具有研究炎症性疾病的潜力。GSK-1482160具有出色的体外效价(在包括人类在内的多种物种的重组和初始P2X7受体的功能和电生理测试中)和交叉靶标选择性。
T2548 Diflorasone

Glucocorticoid Receptor Endocrinology/Hormones
Diflorasone 是一种皮质类固醇激素受体激动剂,具有抗炎和免疫抑制作用。它可通过细胞膜扩散进入细胞,并与细胞质中的糖皮质激素受体结合。它用于研究湿疹、牛皮癣等皮肤病。
T41142 EM 163

IL Receptor; p38 MAPK; MyD88 Immunology/Inflammation; MAPK
EM 163是一种 TIR-TIR 相互作用抑制剂,它是MyD88蛋白的TIR(Toll/白细胞介素-1受体)结构域拟态。EM 163针对IL-1受体中的TIR 结构域,阻断与MyD88的相互作用。EM 163抑制葡萄球菌肠毒素B(SEB)引起的体内炎症细胞因子的产生。EM 163能保护小鼠免受SEB 冲击引起的死亡。在体外的大鼠海马神经元中,EM 163阻断p38的激活和IL-1β对化学诱导的长期电位(LTP)引发的蛋白质合成的抑制作用。
T25453 Glaspimod

F 107647,SK&,F-107647,F107647

Others Others
Glaspimod is a synthetic hematoregulatory peptide. It shares biological and/or modulatory activities with natural hematopoetic cytokines.
T31018 CP 115953

CP115953,Cp-115,953,CP-115953

Others Others
CP 115953 stimulated the production of cytokines by lymphocytes. CP 115953 inhibits the activity of topoisomerase II by interacting with the enzyme.
T70484 AD-35

Others Others
AD-35 is a neuroprotectant for treating Alzheimer’s diseases by significantly inhibiting the production and release of proinflammatory cytokines TNF-α and IL-1β.
T71814 ST026567

Others Others
ST026567 is a potent mast cell (MC) activator which promotes de novo synthesis of cytokines and induces the release of eicosanoids from human and mouse MCs.
T71711 ST029248

Others Others
ST029248 is a potent mast cell (MC) activator, promoting de novo synthesis of cytokines and inducing the release of eicosanoids from human and mouse MCs.
T7503L Upadacitinib tartrate

ABT 494,ABT-494,ABT494

Others Others
Upadacitinib is a potent and selective JAK inhibitor. Upadacitinib is approximately 74 fold selective for Jak1 over Jak2 in cellular assays dependent on specific, relevant cytokines. Upadacitinib demonstrates efficacy in rat arthritis models.
T30831 Cgp 43182

Cgp-43182,Cgp43182

Others Others
CGP 43182 is an effective inhibitor of group IIA secretory phospholipase A2 (Group IIA sPLA2) activity in vitro, which can be used to prevent the synergistic effect of pro-inflammatory genes stimulated by cytokines mediated by NFkappaB.
T16570 Pralnacasan

VX-740,HMR 3480

Others Others
Pralnacasan inhibits proinflammatory cytokines IL-18, IL-1β , and IFN-γ. Pralnacasan is an effective, non-peptide, and orally active interleukin-1β converting enzyme inhibitor (Ki: 1.4 nM). Pralnacasan has the potential for osteoarthritis and rheumatoid a
T70367 SNU-BP

Others Others
SNU-BP is an agonist of PPAR-gamma, inhibiting lipopolysaccharide (LPS)-induced NO production and pro-inflammatory cytokines. SNU-BP potentiates interleukin-4-induced arginase-1 expression, and promotes microglial polarization toward an M2 anti-inflammatory phenotype.
T70001 Pyrazinib

Others Others
Pyrazinib is a novel inhibitor of angiogenesis and metabolism of oesophageal adenocarcinoma (oac) radioresistance, significantly inhibiting the secretion of il-6, il-4, il-8 and il-13 cytokines from in oac radioresistant cells
T10366 Arg-Gly-Asp-Ser

Fibronectin tetrapeptide,RGDS peptide

Others Others
Arg-Gly-Asp-Ser is an integrin-binding sequence that inhibits integrin receptor function. It decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, MMP-9, and iNOS
T60517 CL097 hydrochloride

Others Others
CL097 hydrochloride 是一种有效的 TLR7和 TLR8激动剂。CL097 hydrochloride 可在巨噬细胞中诱导促炎细胞因子和 NADPH 氧化酶启动活性,从而增加 fMLF 刺激的ROS 产生。
T26776 Berteroin

OR-009512,KB-47947,LP-088984,KB47947,LP088984

Others Others
Berteroin is an erucin homolog and potential antioxidant. It is present in cruciferous vegetables, including rucola salad leaves, Chinese cabbage and mustard oil. It decreases the release of pro-inflammatory cytokines in LPS-stimulated macrophages. It als
T81668 NLRP3 agonist 1

NOD-like Receptor (NLR) Immunology/Inflammation
NLRP3 agonist1 (compound 23)为高效口服活性NLRP3激动剂。该化合物能够激活Caspase-1酶,进而将pro-IL-1β与pro-IL-18等促炎细胞因子裂解为成熟型态。
T72223 Anti-inflammatory agent 7

Others Others
Anti-inflammatory agent 7 通过阻断 LPS 处理的 RAW 264.7 细胞和小鼠的 NF-κB/MAPK 信号通路抑制促炎细胞因子。

化合物

(±)-Lisofylline
Cat.No: T21729
Synonym:
Target: Others
GSK717
Cat.No: T38361
Synonym:
Target: IL Receptor, NOD
BRD3308
Cat.No: T8233
Synonym:
Target: Apoptosis, HIV Protease, HDAC
Valsartan
Cat.No: T6716
Synonym: Diovan,缬沙坦,Tareg,CGP 48933
Target: RAAS
6-OAU
Cat.No: T2036
Synonym: GTPL5846
Target: GPR
Naphazoline hydrochloride
Cat.No: T0446
Synonym: 盐酸萘甲唑啉,Albalon,Rhinantin,Naphazoline HCl
Target: Adrenergic Receptor
Naphazoline
Cat.No: T21445
Synonym: AK-Con,Naphcon-a,Clear Eyes,All Clear,萘甲唑林
Target: Adrenergic Receptor
CL097
Cat.No: T38423
Synonym: CL097
Target: Reactive Oxygen Species, TLR
Benznidazol
Cat.No: T4982
Synonym: 苄哒唑,苄硝唑,Radanil,Benznidazole,Ro 71051,Ro 07-1051
Target: Antibiotic, Parasite
CL075
Cat.No: T27034
Synonym: 3M002,CL-075
Target: NF-κB, TLR, MyD88
L-798106
Cat.No: T15689
Synonym: L 798106,CM9,GW-671021,CM-9,GW671021
Target: Prostaglandin Receptor
AVP-13358
Cat.No: T30231
Synonym:
Target: Others
TMC353121
Cat.No: T17107
Synonym:
Target: IL Receptor, TNF, RSV
Resiquimod
Cat.No: T6964
Synonym: R848,雷西莫特,S28463
Target: HCV Protease, TLR
Betamethasone disodium phosphate
Cat.No: T20763
Synonym: Vista-Methasone,NSC90616,Betamethasone 21-phosphate disodium salt,NSC-90616
Target: Others
Oclacitinib maleate
Cat.No: T6914
Synonym: PF-03394197 maleate,奥拉替尼马来酸盐,PF-03394197
Target: Tyrosine Kinases, JAK
Monolaurin
Cat.No: T7872
Synonym:
Target: Others
Delgocitinib
Cat.No: T15096
Synonym: JTE-052,迪高替尼,Corectim(Delgocitinib)
Target: Tyrosine Kinases, JAK
Syk Inhibitor II hydrochloride
Cat.No: T9543
Synonym:
Target: Others
MW01-2-151SRM
Cat.No: T33535
Synonym: MW 151,MW-151,MW012151SRM,MW151,MW01 2 151SRM
Target: Others
Alogliptin Benzoate
Cat.No: T2401
Synonym: 苯甲酸阿格列汀,SYR 322,Alogliptin(SYR-322)benzoate
Target: Ferroptosis, Proteasome, DPP-4
Vadimezan
Cat.No: T6273
Synonym: DMXAA,伐地美生,5,6-Dimethylxanthenone-4-acetic Acid,NSC 640488,ASA-404
Target: Influenza Virus, VDA, STING, IFNAR
AKT-IN-6
Cat.No: T36310
Synonym: INCB-047775
Target: Akt
Zharp2-1
Cat.No: T79600
Synonym:
Target: RIP kinase
Lidocaine
Cat.No: T0468
Synonym: Lignocaine,Alphacaine,Xylocaine,利多卡因
Target: Apoptosis, ERK, NF-κB, MEK, Sodium Channel, Histamine Receptor
CB2R/FAAH modulator-1
Cat.No: T67896
Synonym:
Target: Cannabinoid Receptor, FAAH
C-Reactive Protein (CRP) 174-185 acetate
Cat.No: TP1592L
Synonym: C-Reactive Protein (CRP) 174-185 acetate(160369-86-8 free base)
Target: Others
Guselkumab
Cat.No: T38362
Synonym: CNTO 1959
Target: IL Receptor
Itolizumab
Cat.No: T76781
Synonym: EQ-001
Target: Others
SB-657510
Cat.No: T12848
Synonym:
Target: Others, Neurotensin Receptor
CU-T12-9
Cat.No: T15017
Synonym:
Target: TLR
ABzOH
Cat.No: T67924
Synonym:
Target: Others
GSK-1482160
Cat.No: T61025
Synonym:
Target: P2X Receptor
Diflorasone
Cat.No: T2548
Synonym:
Target: Glucocorticoid Receptor
EM 163
Cat.No: T41142
Synonym:
Target: IL Receptor, p38 MAPK, MyD88
Glaspimod
Cat.No: T25453
Synonym: F 107647,SK&,F-107647,F107647
Target: Others
CP 115953
Cat.No: T31018
Synonym: CP115953,Cp-115,953,CP-115953
Target: Others
AD-35
Cat.No: T70484
Synonym:
Target: Others
ST026567
Cat.No: T71814
Synonym:
Target: Others
ST029248
Cat.No: T71711
Synonym:
Target: Others
Upadacitinib tartrate
Cat.No: T7503L
Synonym: ABT 494,ABT-494,ABT494
Target: Others
Cgp 43182
Cat.No: T30831
Synonym: Cgp-43182,Cgp43182
Target: Others
Pralnacasan
Cat.No: T16570
Synonym: VX-740,HMR 3480
Target: Others
SNU-BP
Cat.No: T70367
Synonym:
Target: Others
Pyrazinib
Cat.No: T70001
Synonym:
Target: Others
Arg-Gly-Asp-Ser
Cat.No: T10366
Synonym: Fibronectin tetrapeptide,RGDS peptide
Target: Others
CL097 hydrochloride
Cat.No: T60517
Synonym:
Target: Others
Berteroin
Cat.No: T26776
Synonym: OR-009512,KB-47947,LP-088984,KB47947,LP088984
Target: Others
NLRP3 agonist 1
Cat.No: T81668
Synonym:
Target: NOD-like Receptor (NLR)
Anti-inflammatory agent 7
Cat.No: T72223
Synonym:
Target: Others
Cat. No. Product Name Target Signaling Pathways
T3S2312 Poncirin

枸橘苷,Isosakuranetin-7-neohesperidoside

Apoptosis; Others Apoptosis; Others
Poncirin (Isosakuranetin-7-neohesperidoside) 是从三叶草中分离出来的一种天然产物,具有抗炎活性。 它防止脂肪生成,增强间充质干细胞中的成骨细胞分化,增加骨矿物质密度,改善小梁微结构,可能反映 GIO 小鼠的骨形成增加和骨吸收减少。
TN1721 Gypenoside L

ERK; p38 MAPK; Calcium Channel; NF-κB; ROS Immunology/Inflammation; MAPK; Membrane transporter/Ion channel; Metabolism; NF-κB
Gypenoside L 是存在于绞股蓝中的一种皂苷,可增加 SA-β-半乳糖苷酶活性,促进衰老相关分泌细胞因子的产生。它还可以激活p38和ERK MAPK 通路和NF-κB 通路以诱导衰老,具有抗肿瘤和抗炎活性。
T9862 Pseudocoptisine chloride

盐酸异黄连碱,Isocoptisine chloride

AChE Neuroscience
Pseudocoptisine chloride (Isocoptisine chloride) 是从 Corydalis Tuber 中分离出来的,具有抗炎和抗健忘的作用。 Pseudocoptisine chloride 抑制乙酰胆碱酯酶 (AChE) 活性 (IC50 = 12.8 μM)。
TN6722 Terminolic acid

2α,6β,23-trihydroxyl oleanolic acid

Antibacterial Microbiology/Virology
Terminolic acid (2α,6β,23-trihydroxyl oleanolic acid) 是一种从 Combretum racemosum 中分离得到的五环三萜糖苷,可通过与 IL-1β 和 IL-6 的受体活性位点结合抑制促炎细胞因子,并通过与 IL-4 受体结合位点结合增强抗炎细胞因子。它还表现出适度的抗菌活性。
TN6796 2'-FUCOSYLLACTOSE

2'-Fucosyl-D-lactose,2'-岩藻糖基乳糖

Others Others
2'-FUCOSYLLACTOSE (2'-Fucosyl-D-lactose) 是一种含岩藻糖的寡糖。
TN1291 7,3',4'-Tri-O-methylluteolin

5-Hydroxy-3',4',7-trimethoxyflavone,木犀草素-7,3',4'-三甲醚

TNF; COX; Interleukin Apoptosis; Immunology/Inflammation; Neuroscience
7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) 是来自草药马鞭草科的一种类黄酮,具有抗炎,解热,镇咳,抗糖尿病、抗癌和抗黑素生成特性。它以浓度依赖方式明显抑制促炎细胞因子,可显著降低在转录水平的诱导型一氧化氮合酶和环加氧酶-2 的 mRNA 表达。
T34295 Resiniferatoxin

RTX,[3H]resiniferatoxin,树脂毒素

IL Receptor Immunology/Inflammation
Resiniferatoxin ([3H]resiniferatoxin) 抑制 Th1 细胞因子的产生,有助于防御 T.spiralis 感染,并可用于免疫反应调节剂的研究。
T2S2150 Noricaritin

诺里卡汀,去甲淫羊藿黄素

Others Others
Noricaritin 是一种来源于淫羊藿根的黄酮类化合物,可诱导肺组织细胞增殖,抑制人肺上皮细胞中促炎细胞因子和趋化因子的产生。
T6S0107 Peimine

贝母素甲,Wanpeinine A,Dihydroisoimperialine,Verticine,贝母甲素

Others Others
Peimine (Wanpeinine A) 是一种天然化合物,具有很好抗炎症活性。
T10689 Cauloside D

Others Others
Cauloside D 是一种分离自 Caulophyllum robustumMax 中的三萜苷类化合物。它能够阻碍 iNOS 和促炎细胞因子的表达,具有抗炎活性。
T14149 AICAR phosphate

AICA Riboside phosphate,Acadesine phosphate

Mitophagy; NOS; YAP; AMPK Autophagy; Chromatin/Epigenetic; Immunology/Inflammation; PI3K/Akt/mTOR signaling; Stem Cells
AICAR phosphate (Acadesine phosphate) 是 AMPK 激活剂且是自噬、YAP 和 mitophagy 抑制剂,也是一种腺苷类似物, 可调节糖代谢和脂代谢,抑制促炎细胞因子和 iNOS 的产生。
T5660 Menthone

IL Receptor; TNF; NF-κB; Parasite Apoptosis; Immunology/Inflammation; Microbiology/Virology; NF-κB
Menthone 是一种从植物和薄荷油中提取的单萜,是精油的主要挥发性成分,具有抗炎和抗氧化特性。
T5S0167 Atractylenolide I

白术内酯 I,白术内酯I;苍术内酯I

IL Receptor; TNF; TLR; JAK; STAT Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Stem Cells
Atractylenolide I 是从白术根中得到的一种倍半萜烯,具有神经保护、抗过敏、抗炎和抗癌等多种生物活性。它是一种TLR4拮抗剂,在 A375 细胞中,能够降低JAK2和STAT3的磷酸化水平。
T3826 Polygalasaponin F

异牡荆苷,瓜子金皂苷己

NF-κB; TLR; Akt; PI3K Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR signaling
Polygalasaponin F 是从瓜子金中提取的齐墩果烷型三萜皂苷,可通过调节TLR4-PI3K/AKT-NF-kB 信号通路减少神经炎症细胞因子的分泌,能降低炎性细胞因子肿瘤坏死因子 α 的释放。
T3829 Ginsenoside F3

人参皂苷F3

Others; IFNAR; Interleukin Immunology/Inflammation; Others
Ginsenoside F3 是一种皂苷,提取自Panax ginseng 叶片。它能够调节1 型 (IL-2, IFN-γ) 及 2 型细胞因子(IL-4 and IL-10) 的产生和表达,有免疫增强的作用。
TN1410 Asperulosidic acid

ASPA,车叶草苷酸

ERK; NF-κB MAPK; NF-κB
Asperulosidic acid (ASPA) 是从白花蛇舌草药中提取的一种环烯醚萜苷,具有抗肿瘤、抗氧化和抗炎作用。它通过抑制 NF-κB 和丝裂原活化蛋白激酶信号通路抑制炎性细胞因子释放发挥抗炎作用。
T5S1895 Norisoboldine

Laurelliptine,去甲异波尔定,(+)-Laurelliptine

MAPK; Adenosine Receptor GPCR/G Protein; MAPK; Neuroscience
Norisoboldine ((+)-Laurelliptine) 是一种可口服的芳基烃受体激动剂,是乌药中主要的异喹啉类生物碱,可用于类风湿性关节炎和溃疡性结肠炎的研究。
TN2091 Polygalacin D

Apoptosis; IAP Apoptosis
Polygalacin D 是从桔梗中分离的一种天然产物,具有抗癌和抗增殖特性。它通过 PI3K/Akt 途径诱导凋亡。它抑制 IAP 蛋白家族的表达,并通过抑制 GSK3β,Akt 的磷酸化和 PI3K 的表达来阻断 PI3K/Akt 途径。
T2S2362 Dehydrocorydaline nitrate

去氢延胡索甲素硝酸盐,硝酸脱氢紫堇碱

BCL; Others; PARP; p38 MAPK; Caspase; Parasite; Autophagy Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Others; Proteases/Proteasome
Dehydrocorydaline nitrate 是生物碱。Dehydrocorydaline 调节 Bax,Bcl-2蛋白表达,激活 caspase-7,caspase-8,并使 PARP 失活。它能增强 p38 MAPK 活化,具有抗炎、抗癌、抗疟疾等功效。
T10065L 2',3'-cGAMP sodium

2'-3'-cyclic GMP-AMP sodium

STING; cGAS Immunology/Inflammation
2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) 是细胞天然免疫中第二信使,在 DNA 结合条件下由 cGAMP 合成酶 (cGAS) 催化形成。2',3'-cGAMP sodium 可与 STING 结合形成二聚体,诱导 IFN-β 及其他细胞因子的产生和表达。
T2S2173 (E)-Naringenin chalcone

Isosalipurpol,柚皮苷查尔酮,Chalconaringenin,trans-2'4'6'4-tetrahydroxychalcone,柚皮素查耳酮

Others Others
Naringenin chalcone (Isosalipurpol) 是一种黄酮醇生物合成的中间体,在查耳酮异构酶的作用下,自发代谢成柚皮素。它具有抗炎和抗过敏活性。
T3426 Bacoside A

MMP; Others; TNF; Dopamine Receptor; NOS; ROS Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuroscience; Others; Proteases/Proteasome
Bacoside A has a possible anticancer activity that could be inducing cell cycle arrest and apoptosis through Notch pathway in GBM in vitro. It exerts cytoprotective efficacy by attenuation of ROS generated through oxidative stress by an increase in the concentration of antioxidant enzymes and sustain membrane integrity which leads to restoring the damage caused by tBHP. Bacoside A can able to inhibit the progression of Experimental Autoimmune Encephalomyelitis (EAE) may be by the inhibition of i...
T3877 Esculentoside A

NF-κB; COX Immunology/Inflammation; Neuroscience; NF-κB
Esculentoside A 是一种三萜皂苷,从商陆根部分离得到。它在具有抗炎活性,对环氧合酶-2 具有选择性抑制活性。它通过抑制NF-κB 和丝裂原活化蛋白激酶信号通路抑制 LPS 诱导的急性肺损伤中的炎症反应。
T3779 Crocin II

Crocin 2,西红花苷II,Crocetin gentiobiosylglucosyl ester,藏红花,Tricrocin,Crocin B

Caspase; COX; NO Synthase Apoptosis; Immunology/Inflammation; Neuroscience; Proteases/Proteasome
Crocin II (Crocetin gentiobiosylglucosyl ester) 是从栀子果实中分离出来的一种天然产物,具有抗氧化、抗癌和抗抑郁活性。它抑制 iNOS 和 COX-2的蛋白质和 m-RNA 的表达,还抑制NO 产生,IC50值为 31.1 μM。
TN1448 (-)-Bornyl acetate

L-(-)-Bornyl acetate,左旋乙酸冰片酯,Bornyl acetate,(-)-乙酸龙脑酯

p38 MAPK; NF-κB; JNK; Antifungal MAPK; Microbiology/Virology; NF-κB
(-)-Bornyl acetate (L-(-)-Bornyl acetate) 是存在于牛膝草油中的一种具有抗真菌活性的 (+)-Bornyl acetate 低活性异构体。
T6S0139 Neobavaisoflavone

Apoptosis; DNA/RNA Synthesis Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
Neobavaisoflavone 是一种从Psoralea corylifolia 的种子中分离出来的类黄酮。它具有抗炎,抗癌和抗氧化的作用。它在中至高浓度下可抑制 DNA 聚合酶,也可抑制血小板聚集。
T5S0045 Isofraxidin

6,8-Dimethoxyumbelliferone,异秦皮啶,Phytodolor,异嗪皮啶

MMP; ERK; p38 MAPK; TLR; COX Immunology/Inflammation; MAPK; Neuroscience; Proteases/Proteasome
Isofraxidin (Phytodolor) 是来自刺五加的香豆素成分,抑制MMP-7表达和人肝癌细胞侵袭。它作用于肝癌细胞,抑制ERK1/2磷酸化。它减弱iNOS 和COX-2表达,还抑制TLR4/髓样分化蛋白 2 复合物的形成。
T9113 Myristicin

Myristicine,肉豆蔻醚

IL Receptor; Anti-infection; BCL; P450; PARP; 5-HT Receptor; Caspase; GABA Receptor; NO Synthase Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome
Myristicin (Myristicine) 是一种在香料和伞形植物中发现的天然产物。肉豆蔻素具有抗胆碱能、抗菌和肝保护作用,还具有抗炎作用,其通过钙途径抑制dsrna 刺激的巨噬细胞中的NO、细胞因子、趋化因子和生长因子。Myristicin 可以诱导细胞凋亡,其特征是改变线粒体膜电位、细胞色素c 释放、Caspase-3激活、parp 切割和DNA 断裂。
T4S0878 Prunetin

樱黄素,Prunusetin

ERK; Dehydrogenase; NF-κB MAPK; Metabolism; NF-κB
Prunetin (Prunusetin) 是一种O-甲基化异黄酮,具有抗炎的作用。它是人醛脱氢酶的有效抑制剂。
T2S2264 Linalool

Linalol,(±)-Linalool,Phantol,沉香醇

Apoptosis; IL Receptor; TNF; Endogenous Metabolite; iGluR Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience
Linalool (Linalol) 是存在芫荽等植物中的单萜类天然产物,是竞争性NMDA 受体拮抗剂,具有抗肿瘤和抗心脏毒性的作用。它通过激活 Nrf2 诱导抗氧化防御和通过抑制 NF-κB 减少炎症反应来保护其免受 LPS/GalN 诱导的肝损伤,具有镇痛、抗菌和抗炎的特性。
TN1831 Macranthoside A

Kalopanaxsaponin H

Antioxidant oxidation-reduction
Macranthoside A (Kalopanaxsaponin H) 是一种从地黄中提取的三萜糖苷,属于环烯醚萜类化合。Macranthoside A 具有抗炎、抗氧化、抗菌和神经保护活性,抑制促炎细胞因子的产生和抑制炎症信号通路的激活,有助于中和有害的自由基,保护细胞免受氧化损伤,可以促进神经元的存活和生长,并防止氧化应激或神经毒性化合物引起的神经元细胞死亡,具有治疗神经退行性疾病、心血管疾病和肝损伤的潜力。
T2563 Acetyl-L-carnitine hydrochloride

Acetyl L-carnitine hydrochloride,O-Acetylcarnitine,乙酰-L-肉(毒)碱盐酸盐,O-acetyl-L-carnitine,O-Acetyl-L-carnitine hydrochloride

Others; Endogenous Metabolite Metabolism; Others
Acetyl-L-carnitine hydrochloride (Acetyl L-carnitine hydrochloride) 是一种由内源性左旋肉碱的乙酰化形式的盐酸盐组成的营养补充剂,具有潜在的神经保护、认知增强、抗抑郁和免疫调节活性。还可缓解化疗、糖尿病或其他疾病引起的周围神经病变。此外,乙酰左旋肉碱可能通过增加T淋巴细胞成熟来调节免疫反应,并可能下调促炎细胞因子对病毒(如SARS-CoV-2)的反应。它还可能破坏ACE2信号通路并抑制活性氧(ROS)的产生。
T4S0797 Berberine

小檗碱,Berberin,Umbellatine,黄连素

Reactive Oxygen Species; Topoisomerase; Endogenous Metabolite; Antibacterial; Antibiotic; Autophagy Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
Berberine (Umbellatine) 属于生物碱类天然产物,可以激活 AMPK、抑制 DNA 拓扑异构酶、诱导 ROS 生成。Berberine 具有抗肿瘤、抗菌、降血糖、降血脂等生物学活性。
T3S2259 Methyl eugenol

4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether,丁香酚甲醚,丁子香酚甲醚

GABA Receptor Membrane transporter/Ion channel; Neuroscience
Methyl eugenol (4-allylveratrole) 是一种苯丙类化合物,存在于植物叶子、果实、根茎中,当植物相应的部位因食草动物进食而受损时,就会释放。它可用于消灭雄性东方果蝇。
T6677 Sophocarpine

ERK; p38 MAPK; NF-κB; TLR; COX; HER; JNK; STAT Angiogenesis; Immunology/Inflammation; JAK/STAT signaling; MAPK; Neuroscience; NF-κB; Stem Cells; Tyrosine Kinase/Adaptors
Sophocarpine 是一种从传统草药苦参中提取的重要生物碱。苦参具有抗病毒、抗肿瘤和抗炎等多种药理作用。它通过多种机制显著抑制癌细胞的生长,具有抗肿瘤活性。
TN1485 Chicanine

Others; NF-κB; Prostaglandin Receptor GPCR/G Protein; Immunology/Inflammation; NF-κB; Others
Chicanine has anti-inflammatory activity in macrophages by down-regulating LPS-induced inflammatory cytokines in IκBα±/MAPK/ERK signaling pathways.
T14877 Cauloside C

Others Others
Cauloside C, a triterpene glycoside isolated from Caulophyllum robustum Max, exerts anti-inflammatory effects through the inhibition of expression of iNOS and proinflammatory cytokines.
TMA2576 Episappanol

IL Receptor; TNF Apoptosis; Immunology/Inflammation
Episappanol has anti-inflammatory activity , it can significantly inhibit the secretion of the pro-inflammatory cytokines interleukin (IL-6) and tumor necrosis factor-alpha (TNF-α).
TN6566 Licoflavanone

Licoflavanone exhibits antioxidant and anti-inflammatory activities,it markedly decreases pro-inflammatory cytokines and cyclooxygenase 2/inducible nitric oxide synthase (COX-2/iNOS) expression levels.
TN4879 Questinol

IL Receptor; TNF; COX; Prostaglandin Receptor Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuroscience
Questinol exhibits significant anti-obesity activity. It shows anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, it can inhibit the production of pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6 and inhibit NO an
T38838 QS-21

Stimulon,QS-21

Others Others
QS-21, an immunostimulatory saponin, is a powerful vaccine adjuvant that stimulates both Th2 humoral and Th1 cell-mediated immune responses by interacting with antigen presenting cells (APCs) and T cells. Additionally, QS-21 activates the NLRP3 inflammasome, leading to the release of cytokines IL-1β and IL-18, which are dependent on caspase-1.
TN4013 Esculentic acid

IL Receptor; TNF; COX Apoptosis; Immunology/Inflammation; Neuroscience
Esculentic acid has anti-inflammatory effect, it has protective effects against LPS-induced endotoxic shock may be mediated, at least in part, by regulation the release of inflammatory cytokines and mediators, and protein expression of COX-2 in mice.
TN1504 Citreorosein

羟基大黄素

cAMP; NF-κB; PI3K GPCR/G Protein; NF-κB; PI3K/Akt/mTOR signaling
Citreorosein is a cAMP phosphodiesterase inhibitor, it has anti-inflammatory effect, inhibits proinflammatory cytokines production through the inhibition of both MAPKs and AKT-mediated IκB kinase (IKK) phosphorylation and subsequent inhibition of transcription factor NF-κB activation.
TN6366 Lupinalbin A

鲁冰花

Lupinalbin A as the most potent estrogen receptor α- and aryl hydrocarbon receptor agonist in Eriosema laurentii de Wild. (Leguminosae). It exerts anti-inflammatory effects via the inhibition of pro-inflammatory cytokines and blocking of IFN-β/STAT1 pathw
T5S0313 Liguiritigenin-7-O-D-apiosyl-4'-O-D-glucoside

Liquiritin apioside,甘草苷元-7-O-D-芹糖-4'-O-D-葡萄糖苷

Others; TNF Apoptosis; Others
Liquiritin apioside has antioxidant property by inducing glutathione (GSH) biosynthesis via the inhibition of cytokines and protected lung epithelial cells against cigarette smoke-mediated oxidative stress, might be as protective agent against epithelial
TN5149 Tirotundin

NF-κB; COX; PPAR DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Neuroscience; NF-κB
Tirotundin is a PPARα/γ dual agonist, it exerts anti-diabetic effect through PPARγ pathway. It shows anti-inflammatory activity, it inhibits inhibit the activation of NF-kappa B, thereby, the synthesis of inflammatory mediators such as cytokines and chemo
T81408 Preleoheterin

Preleoheterin(化合物3)为一类从L. japonicus分离得到的拉丹烷二萜。
TN3983 Ergosta-7,22-dien-3-one

NO Synthase; LTR Immunology/Inflammation
Ergosta-7,22-dien-3-one 是一种羊毛甾烷,能够从台湾灵芝的子实体中分离得到。Ergosta-7,22-dien-3-one 具有促炎特性,它能刺激一氧化氮的产生,诱导基因的表达,并诱导 J774A.1 细胞产生 TLRs、细胞因子、趋化因子和细胞粘附分子。
TN5474 Bonducellin

Bonducellin has anti-inflammatory activities, it can significantly and dose-dependently inhibit the inflammatory mediators; nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12. Bonducellin shows weak antimalarial ac
T38394 PSMα3

Others Others
PSMα3 is a peptide compound that can be utilized to induce tolerance in dendritic cells (DCs) for DC vaccination strategies. It effectively penetrates and modulates human monocyte-derived DCs by modifying the maturation process induced by TLR2 or TLR4. Additionally, PSMα3 inhibits the production of both pro- and anti-inflammatory cytokines and decreases antigen uptake. Notably, PSMα3 is a significant virulence factor released by the most pathogenic strains of methicillin-resistant Staphylococcus...
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天然产物

Poncirin
Cat.No: T3S2312
Synonym: 枸橘苷,Isosakuranetin-7-neohesperidoside
Target: Apoptosis, Others
Gypenoside L
Cat.No: TN1721
Synonym:
Target: ERK, p38 MAPK, Calcium Channel, NF-κB, ROS
Pseudocoptisine chloride
Cat.No: T9862
Synonym: 盐酸异黄连碱,Isocoptisine chloride
Target: AChE
Terminolic acid
Cat.No: TN6722
Synonym: 2α,6β,23-trihydroxyl oleanolic acid
Target: Antibacterial
2'-FUCOSYLLACTOSE
Cat.No: TN6796
Synonym: 2'-Fucosyl-D-lactose,2'-岩藻糖基乳糖
Target: Others
7,3',4'-Tri-O-methylluteolin
Cat.No: TN1291
Synonym: 5-Hydroxy-3',4',7-trimethoxyflavone,木犀草素-7,3',4'-三甲醚
Target: TNF, COX, Interleukin
Resiniferatoxin
Cat.No: T34295
Synonym: RTX,[3H]resiniferatoxin,树脂毒素
Target: IL Receptor
Noricaritin
Cat.No: T2S2150
Synonym: 诺里卡汀,去甲淫羊藿黄素
Target: Others
Peimine
Cat.No: T6S0107
Synonym: 贝母素甲,Wanpeinine A,Dihydroisoimperialine,Verticine,贝母甲素
Target: Others
Cauloside D
Cat.No: T10689
Synonym:
Target: Others
AICAR phosphate
Cat.No: T14149
Synonym: AICA Riboside phosphate,Acadesine phosphate
Target: Mitophagy, NOS, YAP, AMPK
Menthone
Cat.No: T5660
Synonym:
Target: IL Receptor, TNF, NF-κB, Parasite
Atractylenolide I
Cat.No: T5S0167
Synonym: 白术内酯 I,白术内酯I;苍术内酯I
Target: IL Receptor, TNF, TLR, JAK, STAT
Polygalasaponin F
Cat.No: T3826
Synonym: 异牡荆苷,瓜子金皂苷己
Target: NF-κB, TLR, Akt, PI3K
Ginsenoside F3
Cat.No: T3829
Synonym: 人参皂苷F3
Target: Others, IFNAR, Interleukin
Asperulosidic acid
Cat.No: TN1410
Synonym: ASPA,车叶草苷酸
Target: ERK, NF-κB
Norisoboldine
Cat.No: T5S1895
Synonym: Laurelliptine,去甲异波尔定,(+)-Laurelliptine
Target: MAPK, Adenosine Receptor
Polygalacin D
Cat.No: TN2091
Synonym:
Target: Apoptosis, IAP
Dehydrocorydaline nitrate
Cat.No: T2S2362
Synonym: 去氢延胡索甲素硝酸盐,硝酸脱氢紫堇碱
Target: BCL, Others, PARP, p38 MAPK, Caspase, Parasite, Autophagy
2',3'-cGAMP sodium
Cat.No: T10065L
Synonym: 2'-3'-cyclic GMP-AMP sodium
Target: STING, cGAS
(E)-Naringenin chalcone
Cat.No: T2S2173
Synonym: Isosalipurpol,柚皮苷查尔酮,Chalconaringenin,trans-2'4'6'4-tetrahydroxychalcone,柚皮素查耳酮
Target: Others
Bacoside A
Cat.No: T3426
Synonym:
Target: MMP, Others, TNF, Dopamine Receptor, NOS, ROS
Esculentoside A
Cat.No: T3877
Synonym:
Target: NF-κB, COX
Crocin II
Cat.No: T3779
Synonym: Crocin 2,西红花苷II,Crocetin gentiobiosylglucosyl ester,藏红花,Tricrocin,Crocin B
Target: Caspase, COX, NO Synthase
(-)-Bornyl acetate
Cat.No: TN1448
Synonym: L-(-)-Bornyl acetate,左旋乙酸冰片酯,Bornyl acetate,(-)-乙酸龙脑酯
Target: p38 MAPK, NF-κB, JNK, Antifungal
Neobavaisoflavone
Cat.No: T6S0139
Synonym:
Target: Apoptosis, DNA/RNA Synthesis
Isofraxidin
Cat.No: T5S0045
Synonym: 6,8-Dimethoxyumbelliferone,异秦皮啶,Phytodolor,异嗪皮啶
Target: MMP, ERK, p38 MAPK, TLR, COX
Myristicin
Cat.No: T9113
Synonym: Myristicine,肉豆蔻醚
Target: IL Receptor, Anti-infection, BCL, P450, PARP, 5-HT Receptor, Caspase, GABA Receptor, NO Synthase
Prunetin
Cat.No: T4S0878
Synonym: 樱黄素,Prunusetin
Target: ERK, Dehydrogenase, NF-κB
Linalool
Cat.No: T2S2264
Synonym: Linalol,(±)-Linalool,Phantol,沉香醇
Target: Apoptosis, IL Receptor, TNF, Endogenous Metabolite, iGluR
Macranthoside A
Cat.No: TN1831
Synonym: Kalopanaxsaponin H
Target: Antioxidant
Acetyl-L-carnitine hydrochloride
Cat.No: T2563
Synonym: Acetyl L-carnitine hydrochloride,O-Acetylcarnitine,乙酰-L-肉(毒)碱盐酸盐,O-acetyl-L-carnitine,O-Acetyl-L-carnitine hydrochloride
Target: Others, Endogenous Metabolite
Berberine
Cat.No: T4S0797
Synonym: 小檗碱,Berberin,Umbellatine,黄连素
Target: Reactive Oxygen Species, Topoisomerase, Endogenous Metabolite, Antibacterial, Antibiotic, Autophagy
Methyl eugenol
Cat.No: T3S2259
Synonym: 4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether,丁香酚甲醚,丁子香酚甲醚
Target: GABA Receptor
Sophocarpine
Cat.No: T6677
Synonym:
Target: ERK, p38 MAPK, NF-κB, TLR, COX, HER, JNK, STAT
Chicanine
Cat.No: TN1485
Synonym:
Target: Others, NF-κB, Prostaglandin Receptor
Cauloside C
Cat.No: T14877
Synonym:
Target: Others
Episappanol
Cat.No: TMA2576
Synonym:
Target: IL Receptor, TNF
Licoflavanone
Cat.No: TN6566
Synonym:
Target:
Questinol
Cat.No: TN4879
Synonym:
Target: IL Receptor, TNF, COX, Prostaglandin Receptor
QS-21
Cat.No: T38838
Synonym: Stimulon,QS-21
Target: Others
Esculentic acid
Cat.No: TN4013
Synonym:
Target: IL Receptor, TNF, COX
Citreorosein
Cat.No: TN1504
Synonym: 羟基大黄素
Target: cAMP, NF-κB, PI3K
Lupinalbin A
Cat.No: TN6366
Synonym: 鲁冰花
Target:
Liguiritigenin-7-O-D-apiosyl-4'-O-D-glucoside
Cat.No: T5S0313
Synonym: Liquiritin apioside,甘草苷元-7-O-D-芹糖-4'-O-D-葡萄糖苷
Target: Others, TNF
Tirotundin
Cat.No: TN5149
Synonym:
Target: NF-κB, COX, PPAR
Preleoheterin
Cat.No: T81408
Synonym:
Target:
Ergosta-7,22-dien-3-one
Cat.No: TN3983
Synonym:
Target: NO Synthase, LTR
Bonducellin
Cat.No: TN5474
Synonym:
Target:
PSMα3
Cat.No: T38394
Synonym:
Target: Others
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Cat. No. Product Name Species Expression System
TMPY-06981 IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli)

interleukin 1 α,IL1,白介素,IL-1F1,IL1-α,IL-1A,IL1F1,白细胞介素,IL-1 ...

Human E. coli
IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophage...
TMPJ-01210 IL-33 Protein, Mouse, Recombinant

Interleukin-1 family member 11,白细胞介素,NF-HEV and IL- 1F11,白介素...

Mouse E. coli
Mouse Interleukin 33 (IL-33) is a 30 kDa proinflammatory cytokine which may also regulates gene transcription in producer cells. IL-33 is constitutively expressed in smooth muscle and airway epithelia. IL-33 was identified based on sequence and structural homology with IL-1 family cytokines. It is up‑regulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL-1 alpha or IL‑1 beta stimulation. IL-33 is structurally related to IL-1, which induces helper T cells to produ...
TMPK-00114 C-Reactive Protein /CRP Protein, Human, Recombinant (His)

C-reactive protein,MGC88244,PTX1MGC149895,CRP,pentraxin 1,PT...

Human HEK293 Cells
C-reactive protein (CRP) is a polypeptide molecule belonging to the family of pentraxins. CRP is synthesized primarily by the liver in response to certain pro-inflammatory cytokines. It plays an important role in innate immunity, opsonization by its properties, complement activation and immunoglobulins receptor binding. CRP is a protein of the acute systemic inflammation and is, therefore, a prime marker of inflammation.The CRP is quantified by immunonephelometry or immunoturbidimetry. C-Reactiv...
TMPJ-00327 M-CSF/CSF1 Protein, Human, Recombinant (His)

Lanimostim,M-CSF,CSF-1,MCSF,CSF1,集落刺激因子,Macrophage Colony-St...

Human HEK293 Cells
Macrophage Colony-Stimulating Factors (m-csf) are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and themonocytes-macrophages. CSF-1 promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. It also plays an important role in the regulation of osteoclast proliferation and differentiation, the regulatio...
TMPY-02904 TLR4 Protein, Human, Recombinant (His)

TLR-4,TOLL,toll-like receptor 4,ARMD10,TLR4,CD284

Human Baculovirus Insect Cells
TLR4, also known as TLR-4, is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. TLR4 is most abundantly expressed...
TMPJ-01467 Oncostatin M/OSM Protein, Human, Recombinant (E. coli, His)

Oncostatin-M,OSM

Human E. coli
Oncostatin M (OSM) is a glycoprotein belonging to the interleukin-6 family of cytokines that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. OSM encodes a growth regulator, which Inhibits the proliferation of a number of tumor cell lines. It stimulates proliferation of AIDS-KS cells. OSM regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. OSM is considered as a pleiotropic cytokine that initiates its biological ac...
TMPJ-01461 IL-15RA & IL-15 Protein, Human, Recombinant (hFc)

IL-15 Receptor α & IL-15 Fusion Protein,Interleukin-15,IL15R...

Human HEK293 Cells
IL15RA is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells.IL-15 is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 ...
TMPY-02550 Eotaxin/CCL11 Protein, Human, Recombinant (His)

SCYA11,chemokine (C-C motif) ligand 11

Human E. coli
CCL11 or chemokine (C-C motif) ligand 11 is a member of the chemokine (C-C motif) ligand family. Chemokin (C-C motif) ligand 11 is a member of the chemokine family. There are four members of the chemokine family: C-C kemokines, C kemokines, CXC kemokines and CX3C kemokines. The C-C kemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands (CCL)-1 to 28. Chemokines are a family of small ...
TMPJ-01462 IL-15RA & IL-15 Protein, Human, Recombinant - PBS Lyophilized (hFc)

IL15,IL15RA&IL15,IL-15,Interleukin-15,IL-15 Receptor α & IL-...

Human HEK293 Cells
IL15RA is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells.IL-15 is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 ...
TMPK-01029 IL-1RAP/IL-1RAcP Protein, Mouse, Recombinant (aa 21-367, His)

C3orf13,IL1RAP,IL-1 R3,IL-1 RAcP

Mouse HEK293 Cells
Interleukin (IL)-1R3 is the co-receptor in three signaling pathways that involve six cytokines of the IL-1 family (IL-1α, IL-1β, IL-33, IL-36α, IL-36β and IL-36γ). In many diseases, multiple cytokines contribute to disease pathogenesis. For example, in asthma, both IL-33 and IL-1 are of major importance, as are IL-36 and IL-1 in psoriasis.
TMPY-02724 XCL2 Protein, Human, Recombinant (His)

SCM1B,hCG_1729916,SCM-1b,chemokine (C motif) ligand 2,SCYC2

Human Baculovirus Insect Cells
XCL2 is a small cytokine belonging to the XC chemokine family. Chemokines are a group of cytokines. Members of this group of so-called C-Chemokines belong to the SCY family of cytokines and are designated XCL (L for ligand) followed by a number. XCL2 is the new designation of SCM-1-beta. XCL2 is highly related to another chemokine called XCL1. XCL2 gene is located on chromosome 1 in humans. XCL2 is predominantly expressed in activated T cells, but can also be found at low levels in unstimulated ...
TMPK-00646 gp130/IL6ST Protein, Rhesus macaque, Recombinant (His)

IL-6 R β,gp130,IL6ST,IL-6R-beta,CD130,gp130/CD130/IL-6 R β,C...

Rhesus HEK293 Cells
gp130 is a common signal transducing component of the functional receptor complexes for the interleukin (IL)-6 family of cytokines, ie, IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M, ciliary neurotrophic factor, and cardiotrophin-1. These cytokines exhibit pleiotropic biological activities in, for instance, immune, hematopoietic, and neural systems, and function in a redundant manner owing to the shared usage of gp130. gp130/IL6ST Protein, Rhesus macaque, Recombinant (His) is expre...
TMPK-00412 gp130/IL6ST Protein, Human, Recombinant (His)

gp130,CD130,IL-6 R beta,IL6ST,IL-6R-β,IL-6R-beta,IL-6RB,gp13...

Human HEK293 Cells
gp130 is a common signal transducing component of the functional receptor complexes for the interleukin (IL)-6 family of cytokines, ie, IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M, ciliary neurotrophic factor, and cardiotrophin-1. These cytokines exhibit pleiotropic biological activities in, for instance, immune, hematopoietic, and neural systems, and function in a redundant manner owing to the shared usage of gp130. gp130/IL6ST Protein, Human, Recombinant (His) is expressed in H...
TMPJ-00617 IL-33 Protein, Rhesus macaque, Recombinant (His)

Interleukin-33,IL1F11,IL33,白介素,白细胞介素,IL-1F11,Interleukin-1 F...

Rhesus E. coli
Interleukin-33 (IL-33) belongs to the IL-1 superfamily. IL33 is highly expressed in endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes, but almost undetectable in placenta. IL33 induces the production of T helper-2 (Th2)-associated cytokines. IL-33 is a cytokine that mediates its biological effects by binding to and signals through IL1RL1/ST2 and IL-1 Receptor Accessory Protein (IL1RAP), activating intracellular molecules in the NF-κB and MAP kinase signaling pathways...
TMPK-01483 HLA-A*02:03&B2M&AFP (FMNKFIYEI) Monomer Protein, Human, MHC (His & Avi), Biotinylated

AFPD,AFP,Alpha-fetoprotein,HPAFP,MHC,FETA,Alpha-1-fetoprotei...

Human HEK293 Cells
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response.
TMPK-01515 HLA-A*02:01&B2M&AFP (FMNKFIYEI) Monomer Protein, Human, MHC (His & Avi)

HPAFP,Alpha-fetoprotein,MHC,FETA,Alpha-feto,Alpha-1-fetoprot...

Human HEK293 Cells
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response.
TMPY-01033 IL-32 Protein, Human, Recombinant (isoform alpha, His)

IL-32δ,IL-32beta,IL32,TAIFc,IL-32γ,白介素,IL-32 Protein(isoform...

Human HEK293 Cells
IL-32 is a recently discovered cytokine that induces various proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and chemokines in both human and mouse cells through the NF-kappaB and p38 MAPK inflammatory signal pathways. It is regulated robustly by other major proinflammatory cytokines and is crucial to inflammation and immune responses. Four of the IL-32 isoforms (alpha, beta, gamma, and delta) are the most representative IL-32 transcripts, and the gamma isoform of IL-32 is the most active,...
TMPY-04081 Cathepsin H Protein, Mouse, Recombinant (His)

cathepsin H,AL022844

Mouse HEK293 Cells
Proinflammatory cytokines decreased the expression of CTSH in human islets and primary rat beta-cells, and overexpression of CTSH protected insulin-secreting cells against cytokine-induced apoptosis. Cathepsin H Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.6 kDa and the accession number is AAA82966.1.
TMPY-06479 Cathepsin H Protein, Human, Recombinant (His)

CPSB,ACC-5,minichain,ACC4,ACC5,cathepsin H,ACC-4

Human HEK293 Cells
Proinflammatory cytokines decreased the expression of CTSH in human islets and primary rat beta-cells, and overexpression of CTSH protected insulin-secreting cells against cytokine-induced apoptosis. Cathepsin H Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.62 kDa and the accession number is NP_004381.2.
TMPK-00136 ULBP-2 Protein, Human, Recombinant (His & Avi)

ALCAN-α,RAET1L,NKG2D ligand 2,ALCAN-alpha,N2DL2,ULBP-2/5/6,R...

Human HEK293 Cells
ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway, mediating natural killer cell cytotoxicity.
TMPH-02306 VTI1B Protein, Human, Recombinant (His & SUMO)

Vti1-rp1,VTI1B,Vesicle transport through interaction with t-...

Human E. coli
V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence.
TMPH-03543 Enterotoxin type C-3 Protein, S. aureus, Recombinant (His & SUMO)

SEC3,entC3,Enterotoxin type C-3

Staphylococcus aureus E. coli
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of proinflammatory cytokines. Causes also the intoxication staphylococcal food poisoning syndrome. Enterotoxin type C-3 Protein, S. aureus, Recombinant (His & SUMO) is expressed in E. coli expression system wi...
TMPH-03540 Enterotoxin type B Protein, S. aureus, Recombinant (GST)

entB,Enterotoxin type B,SEB

Staphylococcus aureus E. coli
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of proinflammatory cytokines. Causes also the intoxication staphylococcal food poisoning syndrome. Enterotoxin type B Protein, S. aureus, Recombinant (GST) is expressed in E. coli expression system with N-GST ...
TMPH-03545 Enterotoxin type E Protein, S. aureus, Recombinant (His & SUMO)

Enterotoxin type E,SEE,entE

Staphylococcus aureus E. coli
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of proinflammatory cytokines. Causes also the intoxication staphylococcal food poisoning syndrome.
TMPH-03539 Enterotoxin type B Protein, S. aureus, Recombinant (His)

Enterotoxin type B,SEB,entB

Staphylococcus aureus P. pastoris (Yeast)
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of proinflammatory cytokines. Causes also the intoxication staphylococcal food poisoning syndrome.
TMPY-04260 p38 Protein, Human, Recombinant (His)

mitogen-activated protein kinase 14,CSPB1,PRKM14,RK,p38α,CSB...

Human Baculovirus Insect Cells
MAPK14 contains 1 protein kinase domain and belongs to the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. MAPK14 can be detected in the brain, heart, placenta, pancreas, and skeletal muscle and it is expressed to a lesser extent in the lung, liver, and kidney. MAPK14 is activated by various environmental stresses ...
TMPK-01477 HLA-A*02:01&B2M&AFP (FMNKFIYEI) Monomer Protein, Human, MHC (His & Avi), Biotinylated

HPAFP,FETA,Alpha-1-fetoprotein,AFPD,AFP,Alpha-feto,MHC,Alpha...

Human HEK293 Cells
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response.
TMPK-01484 HLA-A*02:03&B2M&AFP (FMNKFIYEI) Monomer Protein, Human, MHC (His & Avi)

HPAFP,FETA,AFP,AFPD,Alpha-1-fetoprotein,MHC,Alpha-fetoprotei...

Human HEK293 Cells
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response.
TMPK-01521 HLA-A*02:01&B2M&AFP (PLFQVPEPV) Monomer Protein, Human, MHC (His & Avi)

MHC,Alpha-feto,AFPD,Alpha-1-fetoprotein,Alpha-fetoprotein,FE...

Human HEK293 Cells
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response.
TMPK-01436 HLA-A*02:01&B2M&AFP (FMNKFIYEI) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled

Alpha-1-fetoprotein,FETA,MHC,Alpha-feto,AFPD,Alpha-fetoprote...

Human HEK293 Cells
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response.
TMPK-01478 HLA-A*02:01&B2M&AFP (PLFQVPEPV) Monomer Protein, Human, MHC (His & Avi), Biotinylated

AFP,FETA,Alpha-feto,HPAFP,Alpha-1-fetoprotein,MHC,Alpha-feto...

Human HEK293 Cells
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response.
TMPK-01519 HLA-A*02:01&B2M&AFP (FMNKFIYEI) Tetramer Protein, Human, MHC (His & Avi)

MHC,FETA,AFP,Alpha-feto,AFPD,Alpha-1-fetoprotein,HPAFP,Alpha...

Human HEK293 Cells
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response.
TMPK-01520 HLA-A*02:01&B2M&AFP (PLFQVPEPV) Tetramer Protein, Human, MHC (His & Avi)

Alpha-1-fetoprotein,AFP,HPAFP,FETA,AFPD,MHC,Alpha-fetoprotei...

Human HEK293 Cells
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response.
TMPK-01417 HLA-A*02:03&B2M&AFP (FMNKFIYEI) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled

Alpha-1-fetoprotein,HPAFP,AFPD,AFP,Alpha-feto,MHC,FETA,Alpha...

Human HEK293 Cells
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response.
TMPK-01482 HLA-A*02:03&B2M&AFP (FMNKFIYEI) Tetramer Protein, Human, MHC (His & Avi)

MHC,AFPD,Alpha-fetoprotein,FETA,Alpha-1-fetoprotein,AFP,HPAF...

Human HEK293 Cells
Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response.
TMPY-02795 Eotaxin-2 Protein, Human, Recombinant (His)

MPIF-2,chemokine (C-C motif) ligand 24,SCYA24,MPIF2,Ckb-6

Human Baculovirus Insect Cells
CCL24, also known as Eotaxin-2 and MPIF-2, belongs to the intercrine beta (chemokine CC) family. CCL24 gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. CCL24 displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. CCL24 is als...
TMPJ-00324 ICAM-1/CD54 Protein, Rhesus macaque, Recombinant (hFc)

Intercellular adhesion molecule 1,ICAM1,CD54,ICAM-1

Rhesus HEK293 Cells
Intercellular adhesion molecule 1 (ICAM1) is known as CD54. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is increased in atherosclerotic and transplant-associated atherosclerotic tissue and animal models of atherosclerosis. Additionally, ICAM-1 has been implicated in the progression of autoimmune diseases. ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-...
TMPK-00492 IL-18BP Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated

Igifbp,Interleukin-18-binding protein,IL-18BP

Cynomolgus HEK293 Cells
Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer,components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesting that IL-18 therapy could enhance anti-tumour immunity. IL-18BP, a high-affinity IL-18 decoy receptor, is frequently upregulated in diverse human and mouse tumours and limits the anti-tumour activity of IL-18 in mice. IL-18BP Protein (Primary Amine Labeling), Cynomolgus, Recombi...
TMPK-00920 IL-1 alpha/IL-1A Protein, Cynomolgus, Recombinant (His)

IL-1A,白介素,IL-1 alpha,Interleukin-1 alpha,IL-1 α,IL1α,Interle...

Cynomolgus HEK293 Cells
The interleukin (IL)-1 family of cytokines is currently comprised of 11 members that have pleiotropic functions in inflammation and cancer. IL-1α and IL-1β were the first members of the IL-1 family to be described, and both signal via the same receptor, IL-1R. Over the last decade, much progress has been made in our understanding of biogenesis of IL-1β and its functions in human diseases.
TMPK-00043 IL-21 Protein, Human, Recombinant (His & Avi), Biotinylated

IL-21,白介素,Interleukin-21,白细胞介素,CVID11,Za11

Human E. coli
Interleukin-21 (IL-21), produced predominantly by CD4 T cells and natural killer T (NKT) cells, is a newly discovered member of the common γ-chain family of cytokines. It has been implicated in many immunological processes and has been linked to autoimmune diseases, allergies and other inflammatory diseases. IL-21 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in E. coli expression system with N-His-Avi tag. The predicted molecular weight is 18.30 kDa and the accession number...
TMPK-00258 Latent TGF beta 3 Protein, Human, Recombinant (His)

TGFβ3,转化生长因子,TGF-β3,TGF-beta3,TGFβ,TGF-β,ARVD,TGFB3,Latent T...

Human HEK293 Cells
Transforming growth factor-betas (TGF-βs) are multifunctional cytokines that have been implicated in the regulation of a broad range of biological processes, including cell proliferation, cell survival, and cell differentiation. And transforming growth factor beta3 (TGFbeta3) is a key protein involved in scar-free healing observed in embryos. Latent TGF beta 3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 45.9 kDa and t...
TMPH-01250 MAP2K3 Protein, Human, Recombinant (His & SUMO)

MAP2K3,MAPK/ERK kinase 3,Dual specificity mitogen-activated ...

Human E. coli
Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. MAP2K3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 55.3 kDa and the accession numbe...
TMPH-01020 BTN3A1 Protein, Human, Recombinant (Yeast, His)

Butyrophilin subfamily 3 member A1,BTN3A1,CD277,BTF5

Human P. pastoris (Yeast)
Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate. BTN3A1 Protein, Human, Recombinant (Yeast, His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 26.2 kDa and the...
TMPK-00893 PGF Protein, Human, Recombinant (hFc)

PlGF,SHGC-10760,PGFL,PGF,D12S1900,PlGF-2

Human HEK293 Cells
Placental growth factor (PGF) is another member of the VEGF family of cytokines with pro-angiogenic and pro-inflammatory effects. Retinal inhibition of PGF in combination with VEGF-A prevents vascular leakage and CNV possibly via modulating their own expression in mononuclear phagocytes. PGF-related, optimized strategies to target inflammation-mediated angiogenesis may help to increase efficacy and reduce non-responders in the treatment of wet AMD patients.
TMPH-03542 Enterotoxin type C-2 Protein, S. aureus, Recombinant

Enterotoxin type C-2,entC2,SEC2

Staphylococcus aureus E. coli
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of proinflammatory cytokines. Causes also the intoxication staphylococcal food poisoning syndrome. Enterotoxin type C-2 Protein, S. aureus, Recombinant is expressed in E. coli expression system. The predicted ...
TMPK-01172 IL-21 Protein, Mouse, Recombinant (His & Avi), Biotinylated

白介素,Interleukin-21,IL-21,Za11,CVID11,白细胞介素

Mouse E. coli
Interleukin-21 (IL-21), produced predominantly by CD4 T cells and natural killer T (NKT) cells, is a newly discovered member of the common γ-chain family of cytokines. It has been implicated in many immunological processes and has been linked to autoimmune diseases, allergies and other inflammatory diseases. IL-21 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in E. coli expression system with N-His-Avi tag. The predicted molecular weight is 17.9 kDa and the accession number ...
TMPH-01021 BTN3A1 Protein, Human, Recombinant (E. coli, His)

CD277,Butyrophilin subfamily 3 member A1,BTN3A1,BTF5

Human E. coli
Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate. BTN3A1 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular wei...
TMPK-00035 IL-4 Protein, Human, Recombinant (His & Avi), Biotinylated

binetrakin,BCGF1,IL4,白介素,白细胞介素,BSF1,IL-4,MGC79402,interleuki...

Human HEK293 Cells
Interleukin-4, also known as IL4, is a secreted protein which belongs to the IL-4 / IL-13 family. Interleukin-4 / IL4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation.In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated, And this cytokine is a ligand for interleukin 4 receptor.
TMPK-00710 Claudin-4 Protein-VLP, Human, Recombinant

Claudin4,CLDN4,Claudin-4,CPETR1,CPE-R,WBSCR8,CPE R

Human HEK293 Cells
Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is overexpressed in many epithelial malignancies and correlates with cancer progression. Changes in CLDN4 expression have been associated with epigenetic factors (such as hypomethylation of promoter DNA), inflammation associated with infection and cytokines, and growth factor signaling. CLDN4 helps to maintain the tumor microenvironment by forming TJs and acts as a barrier to the entry of anticancer drugs in...
TMPK-01248 CXCL4 Protein, Mouse, Recombinant (hFc)

PF-4,CXCL4,SCYB4,Oncostatin-A,Iroplact,MGC138298

Mouse HEK293 Cells
Chemokines regulate leukocyte migration during physiological and pathological conditions. It is currently accepted that these chemotactic cytokines are also important in the development and progression of cancer. CXCL4 and its non-allelic variant CXCL4L1 are two platelet-associated chemokines that have been attributed anti-tumoral activity as a result of their angiostatic potential and the chemotactic activity for anti-tumoral leukocytes. CXCL4 Protein, Mouse, Recombinant (hFc) is expressed in H...
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重组蛋白

IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli)
Cat.No: TMPY-06981
Species: Human
Expression System: E. coli
IL-33 Protein, Mouse, Recombinant
Cat.No: TMPJ-01210
Species: Mouse
Expression System: E. coli
C-Reactive Protein /CRP Protein, Human, Recombinant (His)
Cat.No: TMPK-00114
Species: Human
Expression System: HEK293 Cells
M-CSF/CSF1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00327
Species: Human
Expression System: HEK293 Cells
TLR4 Protein, Human, Recombinant (His)
Cat.No: TMPY-02904
Species: Human
Expression System: Baculovirus Insect Cells
Oncostatin M/OSM Protein, Human, Recombinant (E. coli, His)
Cat.No: TMPJ-01467
Species: Human
Expression System: E. coli
IL-15RA & IL-15 Protein, Human, Recombinant (hFc)
Cat.No: TMPJ-01461
Species: Human
Expression System: HEK293 Cells
Eotaxin/CCL11 Protein, Human, Recombinant (His)
Cat.No: TMPY-02550
Species: Human
Expression System: E. coli
IL-15RA & IL-15 Protein, Human, Recombinant - PBS Lyophilized (hFc)
Cat.No: TMPJ-01462
Species: Human
Expression System: HEK293 Cells
IL-1RAP/IL-1RAcP Protein, Mouse, Recombinant (aa 21-367, His)
Cat.No: TMPK-01029
Species: Mouse
Expression System: HEK293 Cells
XCL2 Protein, Human, Recombinant (His)
Cat.No: TMPY-02724
Species: Human
Expression System: Baculovirus Insect Cells
gp130/IL6ST Protein, Rhesus macaque, Recombinant (His)
Cat.No: TMPK-00646
Species: Rhesus
Expression System: HEK293 Cells
gp130/IL6ST Protein, Human, Recombinant (His)
Cat.No: TMPK-00412
Species: Human
Expression System: HEK293 Cells
IL-33 Protein, Rhesus macaque, Recombinant (His)
Cat.No: TMPJ-00617
Species: Rhesus
Expression System: E. coli
HLA-A*02:03&B2M&AFP (FMNKFIYEI) Monomer Protein, Human, MHC (His & Avi), Biotinylated
Cat.No: TMPK-01483
Species: Human
Expression System: HEK293 Cells
HLA-A*02:01&B2M&AFP (FMNKFIYEI) Monomer Protein, Human, MHC (His & Avi)
Cat.No: TMPK-01515
Species: Human
Expression System: HEK293 Cells
IL-32 Protein, Human, Recombinant (isoform alpha, His)
Cat.No: TMPY-01033
Species: Human
Expression System: HEK293 Cells
Cathepsin H Protein, Mouse, Recombinant (His)
Cat.No: TMPY-04081
Species: Mouse
Expression System: HEK293 Cells
Cathepsin H Protein, Human, Recombinant (His)
Cat.No: TMPY-06479
Species: Human
Expression System: HEK293 Cells
ULBP-2 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00136
Species: Human
Expression System: HEK293 Cells
VTI1B Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPH-02306
Species: Human
Expression System: E. coli
Enterotoxin type C-3 Protein, S. aureus, Recombinant (His & SUMO)
Cat.No: TMPH-03543
Species: Staphylococcus aureus
Expression System: E. coli
Enterotoxin type B Protein, S. aureus, Recombinant (GST)
Cat.No: TMPH-03540
Species: Staphylococcus aureus
Expression System: E. coli
Enterotoxin type E Protein, S. aureus, Recombinant (His & SUMO)
Cat.No: TMPH-03545
Species: Staphylococcus aureus
Expression System: E. coli
Enterotoxin type B Protein, S. aureus, Recombinant (His)
Cat.No: TMPH-03539
Species: Staphylococcus aureus
Expression System: P. pastoris (Yeast)
p38 Protein, Human, Recombinant (His)
Cat.No: TMPY-04260
Species: Human
Expression System: Baculovirus Insect Cells
HLA-A*02:01&B2M&AFP (FMNKFIYEI) Monomer Protein, Human, MHC (His & Avi), Biotinylated
Cat.No: TMPK-01477
Species: Human
Expression System: HEK293 Cells
HLA-A*02:03&B2M&AFP (FMNKFIYEI) Monomer Protein, Human, MHC (His & Avi)
Cat.No: TMPK-01484
Species: Human
Expression System: HEK293 Cells
HLA-A*02:01&B2M&AFP (PLFQVPEPV) Monomer Protein, Human, MHC (His & Avi)
Cat.No: TMPK-01521
Species: Human
Expression System: HEK293 Cells
HLA-A*02:01&B2M&AFP (FMNKFIYEI) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled
Cat.No: TMPK-01436
Species: Human
Expression System: HEK293 Cells
HLA-A*02:01&B2M&AFP (PLFQVPEPV) Monomer Protein, Human, MHC (His & Avi), Biotinylated
Cat.No: TMPK-01478
Species: Human
Expression System: HEK293 Cells
HLA-A*02:01&B2M&AFP (FMNKFIYEI) Tetramer Protein, Human, MHC (His & Avi)
Cat.No: TMPK-01519
Species: Human
Expression System: HEK293 Cells
HLA-A*02:01&B2M&AFP (PLFQVPEPV) Tetramer Protein, Human, MHC (His & Avi)
Cat.No: TMPK-01520
Species: Human
Expression System: HEK293 Cells
HLA-A*02:03&B2M&AFP (FMNKFIYEI) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled
Cat.No: TMPK-01417
Species: Human
Expression System: HEK293 Cells
HLA-A*02:03&B2M&AFP (FMNKFIYEI) Tetramer Protein, Human, MHC (His & Avi)
Cat.No: TMPK-01482
Species: Human
Expression System: HEK293 Cells
Eotaxin-2 Protein, Human, Recombinant (His)
Cat.No: TMPY-02795
Species: Human
Expression System: Baculovirus Insect Cells
ICAM-1/CD54 Protein, Rhesus macaque, Recombinant (hFc)
Cat.No: TMPJ-00324
Species: Rhesus
Expression System: HEK293 Cells
IL-18BP Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated
Cat.No: TMPK-00492
Species: Cynomolgus
Expression System: HEK293 Cells
IL-1 alpha/IL-1A Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-00920
Species: Cynomolgus
Expression System: HEK293 Cells
IL-21 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-00043
Species: Human
Expression System: E. coli
Latent TGF beta 3 Protein, Human, Recombinant (His)
Cat.No: TMPK-00258
Species: Human
Expression System: HEK293 Cells
MAP2K3 Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPH-01250
Species: Human
Expression System: E. coli
BTN3A1 Protein, Human, Recombinant (Yeast, His)
Cat.No: TMPH-01020
Species: Human
Expression System: P. pastoris (Yeast)
PGF Protein, Human, Recombinant (hFc)
Cat.No: TMPK-00893
Species: Human
Expression System: HEK293 Cells
Enterotoxin type C-2 Protein, S. aureus, Recombinant
Cat.No: TMPH-03542
Species: Staphylococcus aureus
Expression System: E. coli
IL-21 Protein, Mouse, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-01172
Species: Mouse
Expression System: E. coli
BTN3A1 Protein, Human, Recombinant (E. coli, His)
Cat.No: TMPH-01021
Species: Human
Expression System: E. coli
IL-4 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-00035
Species: Human
Expression System: HEK293 Cells
Claudin-4 Protein-VLP, Human, Recombinant
Cat.No: TMPK-00710
Species: Human
Expression System: HEK293 Cells
CXCL4 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPK-01248
Species: Mouse
Expression System: HEK293 Cells
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Cat. No. Product Name Target Signaling Pathways
TMID-0262 Lidocaine-d10 (N,N-diethyl-d10)

Lidocaine-d10 (N,N-diethyl-d10) 是 Lidocaine 的氘代化合物。Lidocaine 的 CAS 号为 137-58-6。Lidocaine是一种酰胺衍生物,抑制涉及复杂电压和依赖性的钠通道,可用于研究室性心律失常。它通过调节 miR-145 表达和进一步抑制MEK/ERK和NF-κB信号通路来减少胃癌细胞的生长,迁移和侵袭。
TMID-0254 Linalool-d3

Linalool-d3 是 Linalool 的氘代化合物。Linalool 的 CAS 号为 78-70-6。Linalool 是存在芫荽等植物中的单萜类天然产物,是竞争性NMDA受体拮抗剂,具有抗肿瘤和抗心脏毒性的作用。它通过激活 Nrf2 诱导抗氧化防御和通过抑制 NF-κB 减少炎症反应来保护其免受 LPS/GalN 诱导的肝损伤,具有镇痛、抗菌和抗炎的特性。

同位素标记化合物

Lidocaine-d10 (N,N-diethyl-d10)
Cat.No: TMID-0262
Synonym:
Target:
Linalool-d3
Cat.No: TMID-0254
Synonym:
Target:
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