91
19
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12
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Cat. No. | Product Name | ||
---|---|---|---|
L9810 | 抗纤维化化合物库 | 1180 compounds | |
1180 种潜在的抗纤维化分子,是研究纤维化的有效工具,可以用于高通量筛选和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T22344 |
Icatibant Acetate
|
Bradykinin Receptor | GPCR/G Protein |
Icatibant acetate 是一种特异性缓激肽 B2 受体拮抗剂,其 IC50=1.07 nM,Ki=0.798 nM。 | |||
T35664 |
Tetracosactide acetate
|
Others | Others |
Tetracosactide acetate 是一种合成的多肽,可刺激肾上腺释放皮质类固醇 ,如皮质醇。Tetracosactide acetate 在溃疡性结肠炎和克罗恩病、青少年和成人类风湿性关节炎和骨关节病方面有研究的价值。 | |||
T20615 |
Olsalazine
奥沙拉嗪,Dipentium,Salicylic acid |
Others | Others |
Olsalazine (Dipentium) 是一种抗炎药,用于治疗炎症性肠病。它也是一种新型的 DNA 去甲基化剂。 | |||
T9377 |
ASK1-IN-2
|
Apoptosis; ASK; MAPK | Apoptosis; MAPK |
ASK1-IN-2 是一种口服有活性的凋亡信号调节激酶 1 抑制剂(IC50:32.8 nM)。它可用于研究溃疡性结肠炎。 | |||
T64336 |
Izilendustat
|
HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism |
tert-butyl 4-[[1-[(4-chlorophenyl)methyl]-3-hydroxy-2-oxopyridin-4-yl]methyl]piperazine-1-carboxylate 是一种脯氨酰羟化酶抑制剂。 | |||
T30751 |
Carotegrast methyl
AJM300 |
Integrin | Cytoskeletal Signaling |
Carotegrast methyl (AJM300) 是一种口服有效和选择性 α4 整联蛋白拮抗剂,可预防小鼠结肠炎。HCA2969 是 Carotegrast methyl 的活性代谢产物,是一种特异的双重 α4β1/α4β7 整联蛋白拮抗剂。 | |||
T12079 |
ML604440
|
Proteasome | Proteases/Proteasome; Ubiquitination |
ML604440 是一种特异性的、有效的、细胞可渗透的蛋白酶体 β1i (LMP2) 亚基抑制剂,能够破坏 MHC I 类细胞表面表达,IL-6 分泌以及 naïve T helper 向 17 T helper 细胞的分化。它可以改善实验性结肠炎和 EAE 疾病。 | |||
T10831L |
Cl-amidine hydrochloride
|
Apoptosis; PAD | Apoptosis; Chromatin/Epigenetic |
Cl-amidine hydrochloride 是一种口服有效的PAD 抑制剂,可阻断组蛋白 3 瓜氨酸化和中性粒细胞胞外陷阱的形成,并提高败血症小鼠的存活率。它可诱导癌细胞凋亡,还可诱导 miR-16 引起细胞周期阻滞。 | |||
T4084 |
Sibofimloc
VRT-1353385,Antibiotic-202,Antibiotic 202 |
Antibacterial; Antibiotic | Microbiology/Virology |
Sibofimloc (Antibiotic-202) 是一种肠道限制性的,具有口服活性的 FimH 粘附抑制剂,有抗细菌感染活性,被开发用于治疗炎症性肠病的研究。 | |||
T31482 |
Diloxanide
Diloxanid,RD 3803,RD3803,RD-3803,Diloxanida,二氯尼特 |
Parasite | Microbiology/Virology |
Diloxanide (RD3803) 是一种抗原虫制剂,可研究组织学内阿米巴原虫或者其他原虫感染引起的无症状肠道阿米巴病。它是一种活性的鲁米那抗阿米巴试剂,是由其前药二氯尼特糠酸酯在胃肠道中水解得来的。 | |||
T2171 |
SEW2871
SEW2871 |
S1P Receptor; LPL Receptor | GPCR/G Protein |
SEW 2871 是一种可口服的高选择性 S1P1激动剂,EC50为 13.8 nM。它减少血液中的淋巴细胞数量,可用于糖尿病、阿尔茨海默氏病、肝纤维化和炎症相关研究。它激活 ERK、Akt 和 Rac 信号通路,并诱导 S1P1 内在化和再循环。 | |||
T2525 |
Alosetron hydrochloride
Lotronex,盐酸阿洛司琼,GR 68755C,GR 68755,GR 68755X |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Alosetron hydrochloride (GR 68755) 是一种高选择性的 5-HT3 受体拮抗剂,可减轻清醒或麻醉犬直肠扩张的内脏伤害性效应,具有抗炎活性,用于肠易激综合征的研究。它阻断 5HT3 介导的豚鼠肌间和粘膜下神经元的快速去极化,IC50约为 55 nM。 | |||
T4602 |
Hydrocortisone hemisuccinate
Hydrocortisone 21-he,氢化可的松琥珀酸酯,hydrocortisone 21-hemisuccinate*free acid,Hydrocortisone 21-hemisuccinate |
Glucocorticoid Receptor; Others; Interleukin | Endocrinology/Hormones; Immunology/Inflammation; Others |
Hydrocortisone hemisuccinate (hydrocortisone 21-hemisuccinate*free acid) 是糖皮质激素, 是口服有活性的甾体抗炎剂。它能够降低IL-6(IC50:6.7 μM)、IL-3(IC50:21.4 μM)的生物活性,可用于研究溃疡性结肠炎。 | |||
T3147 |
Pyrrolidinedithiocarbamate ammonium
PDTC,Pyrrolidinedithiocarbamate,吡咯烷二硫代氨基甲酸铵,APDC,1-Pyrrolidinedithiocarboxylic acid ammonium salt,Ammonium pyrrolidinedithiocarbamate,吡咯烷二硫代甲酸铵 |
NF-κB | NF-κB |
Pyrrolidinedithiocarbamate ammonium (1-Pyrrolidinedithiocarboxylic acid ammonium salt) 是一种选择性的、能透过血脑屏障的NF-κB 抑制剂。 | |||
T27020 |
Cilansetron
KC-9946,KC9946,DU-123265,DU123265 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Cilansetron 是一种具有有效性和选择性的 5-HT3 受体拮抗剂,可用于结肠炎引发的相关疾病。 | |||
T9914 |
Vedolizumab
|
Integrin | Cytoskeletal Signaling |
Vedolizumab 是一种人源化单克隆抗体,靶向α4β7整联蛋白,用于溃疡性结肠炎和克罗恩病的相关研究。 | |||
T28285 |
P-2281
P 2281,P2281 |
mTOR | PI3K/Akt/mTOR signaling |
P-2281 是一种 mTOR 抑制剂,具有抗癌和抗炎功效。P-2281 通过抑制 T 细胞功能来抑制葡聚糖硫酸钠 (DSS) 诱导的结肠炎,并且在人类结肠炎的小鼠模型中有效。 | |||
T70084 |
Dersalazine
Dersalazine Free Base |
IL Receptor; Platelet aggregation | Immunology/Inflammation; Others |
Dersalazine (Dersalazine Free Base) 是血小板活化因子抑制剂,通过下调 IL-17表达,在不同啮齿动物型结肠炎中发挥肠道抗炎活性,对溃疡性结肠炎患者具有潜在疗效。 | |||
T0512 |
Phthalylsulfathiazole
酞磺胺噻唑,Sulfathalidine,N4-Phthalylsulfathiazole |
Antibacterial; Antibiotic | Microbiology/Virology |
Phthalylsulfathiazole (N4-Phthalylsulfathiazole) 是磺胺类抗菌药。 | |||
T3620 |
Solcitinib
索西替尼,GLPG-0778,GSK-2586184 |
JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
Solcitinib (GLPG-0778) 是一种可口服的,选择性的竞争性JAK1抑制剂,IC50值为 9.8 nM,可用于银屑病的研究。它对其选择性是对 JAK2、JAK3 和 TYK2 的 11、55 和 23 倍。 | |||
T77582 |
Anti-inflammatory agent 51
|
NF-κB | NF-κB |
Anti-inflammatory agent 51 是一种具有抗炎活性和潜在抗肿瘤活性的酰胺/磺酰胺衍生物,对 NF-κB 激活有抑制作用,可用于研究急性肺损伤和溃疡性结肠炎。 | |||
T1544 |
Olsalazine disodium
Dipentum,奥沙拉秦钠,Olsalazine Sodium |
Others; COX; Antibacterial; Antibiotic | Immunology/Inflammation; Microbiology/Virology; Neuroscience; Others |
Olsalazine disodium (Dipentum) 是抗炎化合物,可作用于溃疡性结肠炎和炎症性肠病。 | |||
T22963 |
McN-A 343
|
AChR | Neuroscience |
McN-A 343作为选择性M1 muscarinic激动剂, 以其刺激交感神经节中muscarinic传导的能力而闻名。在溃疡性结肠炎的实验模型中,它已被发现能有效减轻炎症和氧化应激。 | |||
T2587 |
Ecabet Sodium
TA-2711E,TA-2711,伊卡倍特钠 |
Reactive Oxygen Species; Antibacterial | Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB |
Ecabet Sodium (TA-2711) 可通过抑制活性氧的产生,促进幽门螺杆菌的根除,可用于胃肠道疾病的相关研究。 | |||
T71691 |
Pumafentrine
BY 343 |
PDE | Metabolism |
Pumafentrine(BY 343) 是 PDE3/PDE4双重抑制剂,可降低小鼠实验性结肠炎的临床评分和 TNF 表达。 | |||
T21979 |
P32/98 hemifumarate
P32/98 (hemifumarate)(136259-20-6 free base) |
DPP-4 | Proteases/Proteasome |
P32/98 hemifumarate 是一种二肽基肽酶 IV (DPP4) 抑制剂,具有降血糖作用,可在 Zucker 糖尿病大鼠模型中可改善胰岛素敏感性和 β 细胞反应性,可用于研究2型糖尿病和结肠炎。 | |||
T77404 |
Tesnatilimab
IPH-23XX,JNJ-64304500,JNJ 4500 |
Others | Others |
Tesnatilimab 是一种有效的人源化 IgG4 单克隆抗体,可与免疫激活受体 NKG2D 结合。Tesnatilimab 具有潜在的免疫调节和抗炎活性,可用于研究活动性溃疡性结肠炎 。 | |||
T35898 |
Izencitinib
TD-1473,JNJ-8398 |
JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
Izencitinib (JNJ-8398) 是一种具有口服活性和肠道选择性的 JAK 抑制剂,具有潜在的抗炎活性,可用于研究溃疡性结肠炎和克罗恩病。 | |||
T67942 |
Antimicrobial agent-21
|
MAPK | MAPK |
Antimicrobial agent-21是一种有效的丝裂原活化蛋白激酶抑制剂 ,具有抗菌、抗炎和抗肿瘤活性,可用来治疗白内障,溃疡性结肠炎,脑膜炎和川崎氏病帕金森氏症。 | |||
T64334 |
Glycolithocholic acid, sodium salt
|
Others | Others |
Glycolithocholic acid, sodium salt 是 Glycolithocholic acid 的钠盐。Glycolithocholic acid 是一种甘氨酸结合的次级胆汁酸。Glycolithocholic acid 可用于诊断溃疡性结肠炎 (UC),非酒精性脂肪性肝炎 (NASH0) 和原发性硬化性胆管炎 (PSC)。 | |||
T6923 |
Ozanimod
奥扎莫德,RPC-1063 |
S1P Receptor; LPL Receptor | GPCR/G Protein |
Ozanimod (RPC-1063) 是一种选择性S1P1和S1P5受体激动剂,在[35S]-GTPγS 结合实验中,EC50分别为 410 pM 和 11 nM。它可研究治疗克罗恩病、溃疡性结肠炎、多发性硬化症和复发性多发性硬化症的试验。 | |||
T10208 |
A-69412
N-1-(Fur-3-ylethyl)-N-hydroxyurea |
Lipoxygenase | Metabolism |
A-69412 (N-1-(Fur-3-ylethyl)-N-hydroxyurea) 是一种特异性的 5-脂氧合酶 (5-LO) 的可逆抑制剂。 A-69412 能用于哮喘和溃疡性结肠炎,以及其他炎症和过敏症状的研究。 | |||
T77666 |
MoTPS1-IN-1
|
Antifungal | Microbiology/Virology |
MoTPS1-IN-1(Compound j11),一种MoTPS1抑制剂,可作为抗真菌剂。该化合物通过与MoTPS1的Glu396相互作用发挥抑制作用,进而抑制M. oryzae的致病性。 | |||
T60657 |
(R)-STU104
|
TNF; MAPK | Apoptosis; MAPK |
(R)-STU104 是一种新型 TAK1-MKK3 蛋白-蛋白相互作用 (PPI)抑制剂,抑制 TNF-α,通过与 MKK3 结合并破坏TAK1磷酸化MKK3来抑制TAK1/MKK3/p38/MnK1/MK2/elF4E信号通路。(R)-STU104 是治疗溃疡性结肠炎的候选化合物。 | |||
T76741 |
Eldelumab
BMS-936557,MDX-1100 |
CXCR | Autophagy; GPCR/G Protein; Immunology/Inflammation |
Eldelumab (BMS-936557) 是一种人源化抗 IP-10 IgG 1型单克隆抗体,对 CXCL10 具有抑制作用。Eldelumab 具有抗炎活性,可与 CXCL10 结合,可用于研究类风湿性关节炎。 | |||
T62552 |
Ozanimod hydrochloride
BMS-986374 hydrochloride,RPC-1063 hydrochloride |
S1P Receptor | GPCR/G Protein |
Ozanimod hydrochloride (RPC-1063 hydrochloride) 是一种可口服且具有选择性和高效性的鞘氨醇 1-磷酸 (S1P) 受体调节剂,对S1P1 和 S1P5显示出较高的亲和力。Ozanimod 具有潜在的抗癌活性,可用于研究复发性多发性硬化 (MS) 、溃疡性结肠炎、冠状病毒感染和骨髓增生。 | |||
T5095 |
Oxazolone
4-乙氧基亚甲基-2-苯基-2-唑啉-5-酮,4-Ethoxymethylene-2-phenyl-2-oxazolin-5-one |
Others | Others |
Oxazolone 已被用作半抗原化剂,可在成年斑马鱼肠道组织中诱导炎症反应,并可用作两种形式的炎症性肠病(如克罗恩病和溃疡性结肠炎)的基因表达研究模型。 | |||
T4615 |
Balsalazide sodium hydrate
巴柳氮钠水合物,Balsalazide disodium dihydrate,巴柳氮钠,Balsalazide disodium salt dihydrate,Balsalazide disodium |
STAT; Interleukin | Immunology/Inflammation; JAK/STAT signaling; Stem Cells |
Balsalazide sodium hydrate (Balsalazide disodium) 可通过调节IL-6/STAT3通路起抑癌作用,可用于治疗炎症性肠病。 | |||
T27150 |
Dersalazine sodium
UR12746,Dersalazine,UR 12746S (sodium salt),UR-12746S (sodium salt),UR-12746 |
Others | Others |
Dersalazine, a PAF antagonist and TNFα inhibitor, is used potentially for the treatment of ulcerative colitis. It showed anti-inflammatory effect in reactivated colitis in rats, as evidenced by a significant reduction in MPO activity. | |||
T34831 |
Teupolioside
trans-Lamalboside,Lamiuside A,Teupolioside HTN |
Others | Others |
Teupolioside is a putatively ameliorates colitis that is isolated from Ajuga reptans. | |||
T68355 |
BTZO-15
|
Others | Others |
BTZO-15 is a novel ARE activator, ameliorating DSS- and TNBS-induced colitis in rats. | |||
T61826 |
NLRP3-IN-4
|
Others | Others |
NLRP3-IN-4 is a highly efficient and orally bioavailable inhibitor of NLRP3 inflammasome, which exhibits strong anti-inflammatory properties specifically targeted towards colitis. | |||
T69287 |
NAA-004
|
Others | Others |
NAA-004, also known as APAZA, has been shown to significantly inhibit toxin A-induced myeloperoxidase activity, luminal fluid accumulation, and structural damage to the colon in instances of toxin A-induced colitis. | |||
T34126 |
Prednisolone sodium metazoate
|
Others | Others |
Prednisolone sodium metazoate is used in the treatment of Inflammatory Bowel Disease, Ulcerative Colitis, and GI Disorders. | |||
T72406 |
Tofacitinib Prodrug-1
|
Others | Others |
Tofacitinib Prodrug-1 是减轻托法替尼 (Tofacitinib) 全身性不良反应的口服有效前药。Tofacitinib Prodrug-1 能在小鼠模型有效减轻恶唑酮诱导的结肠炎,具有低毒性,是治疗溃疡性结肠炎的潜在候选药物。 | |||
T29013 |
HE 3286
Triolex,HE-3286,HE3286 |
Others | Others |
Triolex, an NF-kB inhibitor, is used potentially for the treatment of rheumatoid arthritis, ulcerative colitis. | |||
T26680 |
ATL-801
|
Others | Others |
ATL-801 is anselective antagonist of A2B receptor with herapeutic activity for colitis. | |||
T27142 |
Delmitide
Rationally Designed Peptide-58,RDP-1258,RDP5,Allotrap-1258,RDP1258,RDP-5 |
||
Delmitide, a TNF-alpha production inhibitor, is used potentially for the treatment of Crohn's disease and ulcerative colitis. | |||
T68891 |
Rivanicline galactarate
|
Others | Others |
Rivanicline galactarate is a Nicotinic Receptor Agonist that may be useful in the treatment of Ulcerative Colitis. | |||
T71314 |
GL-V9
|
Others | Others |
GL-V9 is an AMPK activator, protecting against colitis-associated colorectal cancer by limiting NLRP3 inflammasome through autophagy. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2S0342 |
Armillarisin A
|
Others; Interleukin | Immunology/Inflammation; Others |
Armillarisin A 具有上调 IL-4和下调 IL-1β 的效果,对溃疡性结肠炎具有潜在的研究价值。 | |||
T6S1027 |
Tussilagone
|
Others | Others |
Tussilagone 是Tussilago farfara 的主要活性成分,具有抗炎作用。它抑制盲肠结扎和穿刺导致脓毒症的小鼠的炎症反应,提高其生存率。它改善葡聚糖硫酸钠诱导的小鼠结肠炎的炎症反应。 | |||
TN1084 |
1,3,5,8-Tetrahydroxyxanthone
Desmethylbellidifolin,去甲基雏叶龙胆酮 |
Anti-infection | Microbiology/Virology |
1,3,5,8-Tetrahydroxyxanthone (Desmethylbellidifolin) 是一种天然黄酮,从 Gentianella acuta 中提取得到。它具有镇痉作用和抗炎作用。 | |||
T2718 |
Palmatine chloride
|
Others; Indoleamine 2,3-Dioxygenase (IDO); Aurora Kinase | Cell Cycle/Checkpoint; Chromatin/Epigenetic; Metabolism; Others |
Palmatine chloride 是口服具有活力的不可逆 IDO-1抑制剂。它能够减轻结肠损伤,预防肠道菌群失调和调节色氨酸分解代谢,并改善 DSS 诱发的结肠炎。 | |||
T5S0802 |
Palmatine
巴马汀,Berbericinine,Burasaine |
Indoleamine 2,3-Dioxygenase (IDO); AChR; AChE; Aurora Kinase | Cell Cycle/Checkpoint; Chromatin/Epigenetic; Metabolism; Neuroscience |
Palmatine (Burasaine) 是口服具有活力的、不可逆IDO-1抑制剂。它可以减轻结肠损伤,预防肠道菌群失调和调节色氨酸分解代谢,从而改善DSS (Dextran Sulphate Sodium Salt) 诱发的结肠炎。它有用于结肠炎的研究潜力。 | |||
T31964 |
Glycolithocholic acid
Lithocholic acid glycine conjugate,甘氨石胆酸,Lithocholylglycine |
Endogenous Metabolite | Metabolism |
Glycolithocholic acid (Lithocholic acid glycine conjugate) 属于内源性代谢产物,是甘氨酸结合的次级胆汁酸。它可用于诊断非酒精性脂肪性肝炎,溃疡性结肠炎和原发性硬化性胆管炎。 | |||
T8160 |
EGCG Octaacetate
乙酰化表没食子儿茶素没食子酸酯,乙酰化EGCG |
Others; Antibacterial | Microbiology/Virology; Others |
EGCG Octaacetate 是表没食子儿茶素没食子酸酯的前药,对革兰氏阳性菌和革兰氏阴性菌有潜在抗菌可能。它可下调 PI3K/Akt/NFκB 磷酸化和 p65 乙酰化来降低促炎介质水平,减少小鼠结肠炎引起的结肠癌。 | |||
TN1238 |
3,4-O-Isopropylidene-shikimic acid
3,4-O-异亚丙基莽草酸,3,4-O-Isopropylidene shikimic acid |
NOS; NO Synthase | Immunology/Inflammation |
3,4-O-Isopropylidene-shikimic acid (3,4-O-Isopropylidene shikimic acid) 是一种从Hypericum wightianum 中提取得到的天然产物。它具有抗炎症和抗氧化作用。 | |||
T7908 |
DL-Methionine Methylsulfonium Chloride
DL-蛋氨酸甲基氯化锍,维生素U |
Others | Others |
DL-methionine methylsulfonium chloride 是天然的蛋氨酸衍生物。它能够有效保护胃粘膜,避免其受到乙醇诱导的损伤。 | |||
TN1370 |
Allura Red AC
Allura Red,CI 16035,FD&C RED NO. 40 |
Others; Estrogen/progestogen Receptor; Androgen Receptor | Endocrinology/Hormones; Others |
Allura Red AC (CI 16035) 是一种非常重要的食用偶氮染料,可用于食品、药品、造纸、化妆品和纺织行业。Allura Red AC 可通过小鼠肠道血清素促进实验性结肠炎的易感性。 | |||
T2735 |
5-Acetylsalicylic acid
5-乙酰水杨酸(阿司匹林),5-acetyl-2-hydroxybenzoic acid |
Others | Others |
5-Acetylsalicylic acid (5-acetyl-2-hydroxybenzoic acid) 是炎症性肠病中的活性剂,具有抗炎活性。 | |||
TN7235 |
4-methoxylonchocarpin
|
TNF; NF-κB | Apoptosis; NF-κB |
4-methoxylonchocarpin 是从Abrus precatorius 的根中分离出来的以一种有效的抗炎化合物。4-methoxylonchocarpin 通过抑制LPS 与巨噬细胞的TLR4结合来抑制NF-κB 激活TNF 表达,抑制TNBS 引起的小鼠结肠炎。 | |||
T6S1579 |
Monotropein
水晶兰苷,Monotropeine |
Others | Others |
Monotropein (Monotropeine) 是从Morinda officinalis 中获得,能够抑制硫酸葡聚糖硫酸钠诱导的结肠炎小鼠模型中炎性因子的表达。 | |||
TN5770 |
Gingerenone A
|
Nrf2 | Immunology/Inflammation |
Gingerenone A 是一种有效的 Nrf2-Gpx4 激活剂,是从生姜里面分离出来的小分子化合物,具有抗癌活性,可延长癌细胞的细胞周期,可抑制右旋糖酐硫酸钠 (DSS) 诱导的结肠炎小鼠继发性肝损伤 (SLI) 中的铁死亡。 | |||
T5S1177 |
Aloin B
Isobarbaloin,芦荟苷B,芦荟素B |
Others | Others |
Aloin B (Isobarbaloin) 是一种芦荟素的异构体。其中芦荟素是芦荟中的具生理活性蒽醌化合物。 | |||
T3929 |
Kaurenoic acid
Kauren-19-Oic Acid,异贝壳杉烯酸,kaurenoate,kaur-16-en-18-oic acid |
Others | Others |
Kaurenoic acid (kaurenoate) 是一种二萜,来源于 Sphagneticola trilobata 中,可以抑制细胞因子的产生和激活 NO–cyclic GMP–PKG–ATP- 敏感型钾通道信号通路,并抑制炎症疼痛。 | |||
T75433 |
Norisoboldine hydrochloride
|
Others | Others |
Norisoboldine hydrochloride是一种口服活性天然芳基烃受体(AhR)激动剂,作为林参中的主要异喹啉类生物碱,适用于类风湿性关节炎和溃疡性结肠炎的研究。 | |||
T38330 |
Collinin
|
Others | Others |
Collinin is a coumarin that has been found in Z. schinifolium and has diverse biological activities.1,2,3,4 It is active against drug-susceptible and -resistant strains of M. tuberculosis (MIC50s = 3.13-6.25 μg/ml).1 Collinin inhibits LPS-induced nitric oxide (NO) production (IC50 = 5.9 μM) and reduces COX-2 protein levels in RAW 264.7 cells.2 It completely inhibits aggregation of isolated rabbit platelets induced by arachidonic acid , collagen, or platelet activating factor (PAF) when used at a... | |||
T37770 |
Taurohyodeoxycholic acid
|
Others | Others |
Taurohyodeoxycholic acid (THDCA) is a taurine-conjugated form of the secondary bile acid hyodeoxycholic acid .1THDCA decreases the size and weight of human gallstonesin vitro. It increases bile flow, biliary cholesterol secretion, and biliary lipid secretion in rats.2Co-administration of THDCA with taurochenodeoxycholic acid prevents TCDCA-induced hepatotoxicity, increasing bile flow as well as biliary acid and phospholipid secretion in rats.3THDCA also reduces myeloperoxidase activity, expressi... |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-00493 |
IL-19 Protein, Human, Recombinant (His)
interleukin 19,Interleukin-19,IL-10C,NG.1,ZMDA1,MDA1 |
Human | Baculovirus Insect Cells |
The molecular features at the IL19 locus may modestly alter the establishment of HIV-1 infection. Interleukin (IL) 19, IL-20, and IL-24 belong to the IL-10 cytokine family and have been identified to play a role in the regulation of epidermal functions and inflammation. The expression of IL19 in biopsies of patients with active ulcerative colitis was increased compared with patients with quiescent ulcerative colitis and that colitis was attenuated in IL-19-deficient mice. The disruption of the e... | |||
TMPK-01137 |
FAM3D Protein, Human, Recombinant (hFc)
OIT1,EF7,FAM3D |
Human | HEK293 Cells |
The physiological homeostasis of gut mucosal barrier is maintained by both genetic and environmental factors and its impairment leads to pathogenesis such as inflammatory bowel disease. A cytokine like molecule, FAM3D (mouse Fam3D), is highly expressed in mouse gastrointestinal tract. Here, we demonstrate that deficiency in Fam3D is associated with impaired integrity of colonic mucosa, increased epithelial hyper-proliferation, reduced anti-microbial peptide production and increased sensitivity t... | |||
TMPY-03673 |
REG3B Protein, Mouse, Recombinant (His)
Pap,HIP,REG-III,PAP1 |
Mouse | HEK293 Cells |
Expression of REG3B was sufficient to inhibit cytokine-induced activation of STAT3 in IECs. The human REG3beta protein, the functional counterpart of mouse REG3B, inhibited STAT3 activity in human 293T cells, and its expression level in colorectal tumors correlated inversely with pSTAT3 level and survival times of patients. REG3B negatively regulates cytokine-induced activation of STAT3 in colon epithelial cells. This pathway might be targeted in patients with colitis to reduce carcinogenesis. | |||
TMPK-00971 |
CRTAM Protein, Mouse, Recombinant (His)
CRTAM,CD355,CD355 antigen |
Mouse | HEK293 Cells |
Class-I Restricted T Cell-Associated Molecule (CRTAM) is a protein that is expressed after T cell activation. The interaction of CRTAM with its ligand, nectin-like 2 (Necl2), is required for the efficient production of IL-17, IL-22, and IFNγ by murine CD4 T cells, and it plays a role in optimal CD8 T and NK cell cytotoxicity. CRTAM promotes the pro-inflammatory cytokine profile; therefore, it may take part in the immunopathology of autoimmune diseases such as diabetes type 1 or colitis. CRTAM Pr... | |||
TMPK-01385 |
CRTAM Protein, Canine, Recombinant (His)
CRTAM,CD355 antigen,CD355 |
Canine | HEK293 Cells |
Class-I Restricted T Cell-Associated Molecule (CRTAM) is a protein that is expressed after T cell activation. The interaction of CRTAM with its ligand, nectin-like 2 (Necl2), is required for the efficient production of IL-17, IL-22, and IFNγ by murine CD4 T cells, and it plays a role in optimal CD8 T and NK cell cytotoxicity. CRTAM promotes the pro-inflammatory cytokine profile; therefore, it may take part in the immunopathology of autoimmune diseases such as diabetes type 1 or colitis. CRTAM Pr... | |||
TMPY-03172 |
Argininosuccinate lyase Protein, Human, Recombinant (His & GST)
ASAL,argininosuccinate lyase,ASL |
Human | Baculovirus Insect Cells |
The recycling of citrulline by argininosuccinate synthase 1 (ASS1) and argininosuccinate lyase (ASL) is crucial to maintain arginine availability and nitric oxide (NO) production. Nitric oxide (NO) plays an established role in numerous physiological and pathological processes, but the specific cellular sources of NO in disease pathogenesis remain unclear, preventing the implementation of NO-related therapy. Argininosuccinate lyase (ASL) is the only enzyme able to produce arginine, the substrate ... | |||
TMPY-00176 |
FNDC4 Protein, Human, Recombinant (mFc)
fibronectin type III domain containing 4,FRCP1 |
Human | HEK293 Cells |
FNDC4 acts as an anti-inflammatory factor on macrophages and improves mouse model of induced colitis. FNDC4 could suppress osteoclast formation via NF-kappaB pathway and downregulation of CXCL10. Analysis of binding of FNDC4 to different immune cell types reveals strong and specific binding to macrophages and monocytes. FNDC4 treatment of bone marrow-derived macrophages in vitro results in reduced phagocytosis, increased cell survival and reduced proinflammatory chemokine expression. Hence, trea... | |||
TMPY-03308 |
ADAM17 Protein, Rat, Recombinant (His)
ADAM metallopeptidase domain 17 |
Rat | HEK293 Cells |
ADAM17 is a member of the ADAM protein family of disintegrins and metalloproteases. ADAM17 is ubiquitously expressed in the human colon, with increased activity in the colonic mucosa of patients with ulcerative colitis, a main form of inflammatory bowel disease. The expression of ADAM17 may be inhibited by ethanol. It is involved in the processing of tumor necrosis factor alpha (TNF-α) at the surface of the cell, and from within the intracellular membranes of the trans-Golgi network. ADAM1... | |||
TMPY-02952 |
SIAE Protein, Human, Recombinant (His)
CSE-C,AIS6,CSEC,LSE,YSG2,sialic acid acetylesterase |
Human | Baculovirus Insect Cells |
Sialate O-acetylesterase belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. It is widely expressed with high expression in the testis, prostate, and colon. The systematic name of this enzyme class is N-acyl-O-acetylneuraminate O-acetylhydrolase. Other names in common use include N-acetylneuraminate acetyltransferase, sialate 9(4)-O-acetylesterase, and sialidase. Sialate O-acetylesterase catalyzes the removal of O-acetyl ester groups from position 9 of the p... | |||
TMPY-01033 |
IL-32 Protein, Human, Recombinant (isoform alpha, His)
IL-32δ,IL-32beta,IL32,TAIFc,IL-32γ,白介素,IL-32 Protein(isoform... |
Human | HEK293 Cells |
IL-32 is a recently discovered cytokine that induces various proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and chemokines in both human and mouse cells through the NF-kappaB and p38 MAPK inflammatory signal pathways. It is regulated robustly by other major proinflammatory cytokines and is crucial to inflammation and immune responses. Four of the IL-32 isoforms (alpha, beta, gamma, and delta) are the most representative IL-32 transcripts, and the gamma isoform of IL-32 is the most active,... | |||
TMPJ-00698 |
BTNL2 Protein, Mouse, Recombinant (His)
Ng9,Butyrophilin-like protein 2,Btnl2,Gm315 |
Mouse | HEK293 Cells |
Butyrophilin-like 2 (BTNL2) is a member of the BTN/MOG Ig-superfamily and functions as a negative regulator of immune cell activation. Mouse BTNL2 is type I transmembrane glycoprotein that contains an extracellular domain (ECD), a transmembrane region and a short cytoplasmic domain. The ECD features two V-type Ig-like domains, two C-type Ig-like domains, and four glycosylation sites. BTNL2 is expressed in epithelial cells of the small intestine, colonic dendritic cells, and in cells of the lymph... | |||
TMPY-01000 |
BVES Protein, Human, Recombinant (GST)
CARICK,LGMD2X,POP1,blood vessel epicardial substance,POPDC1,... |
Human | E. coli |
Blood vessel epicardial substance (BVES), or POPDC1, is a tight junction-associated transmembrane protein that modulates epithelial-to-mesenchymal transition (EMT) via junctional signaling pathways. BVES plays a protective role both in ulcerative and infectious colitis and identify BVES as a critical protector of colonic mucosal integrity. The Popeye domain containing1, also called Bves (Popdc1/Bves), is a transmembrane protein that functions in muscle regeneration, heart rate regulation, hypoxi... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T70214 |
BMS-986202
|
||
BMS-986202 is a novel Tyk2 inhibitor, binding to Tyk2 JH2, showing efficacies for IL-23-driven acanthosis, anti-CD40-induced colitis, and spontaneous lupus. | |||
T71293 |
Nifuroxazide-d4
|
||
Nifuroxazide-d4 is intended for use as an internal standard for the quantification of nifuroxazide by GC- or LC-MS. Nifuroxazide is a nitrofuran antibiotic. It is active against strains of the enteropathogenic bacteria C. jejuni, Salmonella, Y. enterocolitica, Shigella, and E. coli. It inhibits quorum sensing and virulence factor production in P. aeruginosa. Nifuroxazide inhibits STAT3 activity in a reporter assay and decreases viability of U266 and INA-6 myeloma cells, which have constitutive S... |