P2Y14R antagonist 2 (compound 39) is an effective and selective orally-active antagonist of P2Y14R with an IC50 of 0.40 nM. It exhibits anti-inflammatory properties and holds potential for use in studying colitis.

P2Y14 Receptor:0.40 nM

P2Y14R拮抗剂2（每日一次，连续七天通过直肠给药，每只小鼠100µL，浓度分别为50, 100 µM）对实验性结肠炎小鼠模型具有显著的抗炎作用。该小鼠模型选用6-8周龄，体重20-22g的雄性C57BL/6小鼠（结肠炎）。