购物车
- 全部删除
- 您的购物车当前为空
RS-246204 is an R-spondin-1 substitute compound. RS-246204 is able to initiate small intestinal organoids without the use of the R-spondin-1 protein.
为众多的药物研发团队赋能,
让新药发现更简单!
RS-246204 is an R-spondin-1 substitute compound. RS-246204 is able to initiate small intestinal organoids without the use of the R-spondin-1 protein.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
2 mg | ¥ 1,950 | 5日内发货 | |
5 mg | ¥ 2,890 | 5日内发货 | |
25 mg | ¥ 10,600 | 6-8周 | |
50 mg | ¥ 13,800 | 6-8周 | |
100 mg | ¥ 17,500 | 6-8周 | |
1 mL x 10 mM (in DMSO) | ¥ 3,180 | 5日内发货 |
产品描述 | RS-246204 is an R-spondin-1 substitute compound. RS-246204 is able to initiate small intestinal organoids without the use of the R-spondin-1 protein. |
体外活性 | RS-246204 could promote the initial formation and growth of enteroids in the medium without R-spondin-1. The enteroids grown with RS-246204 had a similar differentiation capacity as well as self-renewal capacity as the enteroids grown with R-spondin-1. The RS-246204-derived enteroids could successfully produce the forskolin-induced swelling and the organoid based epithelial to mesenchymal transition model [1]. |
体内活性 | RS-246204 obviously enhanced BrdU+ cells and body weight in the DSS induced colitis model. RS-246204 activates the R-spondin dependent pathway in Lgr5 stem cells, thereby enhancing proliferation or the anti-apoptotic effect, promoting regeneration of the intestinal epithelium and reducing the disease severity [1]. |
分子量 | 339.37 |
分子式 | C16H13N5O2S |
CAS No. | 878451-87-7 |
密度 | 1.54 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
溶解度信息 | DMSO: 5 mg/mL (14.73 mM), Sonication is recommended. | ||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||
DMSO
|
评论内容