The effects of TAE-1 on differentiated human SH-SY5Y neuronal cells grown in tissue culture.?Results showed that the stimulation of neuronal cellular process length and branching was noted.?Moreover, the increased synaptophysin suggested that TAE-1 could stimulate synapse formation.?Increased expression of MAP2 was also observed, indicating that TAE-1 promoted the differentiation of human neurons.?In addition, targeted AChE inhibition was evaluated by electrochemical quantification of the enzymatic product, thiocholine, on unmodified gold screen-printed electrodes.?It was found that at increasing TAE-1concentrations, there was a corresponding decrease in the AChE activity resulting in reduced amount of oxidizable thiocholine.?The IC50 value was found to be 0.465 μM for TAE-1[1]