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Pericyazine

Name: Pericyazine
Brand: TargetMol
SKU: T16472
Price: 247 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 氰噻嗪, RP 8909, Propericiazine

货号 T16472Cas号 2622-26-6 一键复制产品信息纯度: 99.61%

很棒

Pericyazine (Propericiazine) 是第一代抗精神病药物，是一种选择性的 D2 多巴胺受体 (D2-dopamine receptor) 拮抗剂，具有肾上腺溶解、抗胆碱能和锥体外系作用，被用作短期管理严重焦虑状态和精神病的辅助药物。

Pericyazine

一键复制产品信息

很棒

纯度: 99.61%

货号 T16472Cas号 2622-26-6

别名 氰噻嗪, RP 8909, Propericiazine

为众多的药物研发团队赋能，

让新药发现更简单！

规格	价格	库存
1 mg	¥ 247	现货
5 mg	¥ 662	现货
10 mg	¥ 1,070	现货
25 mg	¥ 2,150	现货
50 mg	¥ 3,560	现货
100 mg	¥ 4,970	现货
200 mg	¥ 6,860	现货
1 mL x 10 mM (in DMSO)	¥ 532	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.61%

颜色: 黄色

性状: Solid

资源下载: COA LCMS HNMR产品操作手册

产品介绍

Pericyazine AI Summary

Pericyazine exhibits a diverse range of bioactivities with significant biochemical and pharmacological properties. It has a dissociation constant (pKa) of 8.76, indicating moderate acidity/basicity, and a partition coefficient (log P) of 3.52, which suggests its lipophilicity. It interacts with androgen receptors, shown by a Ki value of 3000.0 nM in displacing [3H]mibolerone. The compound is a potent inhibitor of Lamin A splicing (6.3 nM) and has moderate inhibitory effects on the ERK signaling pathway (10000.0 nM) and other biological targets, including GCN5L2, human tyrosyl-DNA phosphodiesterase 1, and several viral activities. Pericyazine also shows selective enzyme inhibition, with IC50 values of 7000.0 nM for AChE and 230.0 nM for BChE, and a selectivity index ratio of 30.0 towards BChE. It demonstrates antiplasmodial activity with an IC50 of 6562.0 nM against Plasmodium falciparum. Furthermore, it exhibits antiviral activity against SARS-CoV-2, inhibiting the main protease with residual activity of 55.0% at 100 uM, and various other targets such as OATP transporters and cholinesterase enzymes. The compound's bioactivities cover a broad spectrum, indicating its potential for diverse therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Pericyazine (Propericiazine) is a selective D2-dopamine receptor antagonist. Pericyazine is a first-generation antipsychotic drug that is used as an adjunct to the short-term management of severe anxiety states and psychosis.
别名	氰噻嗪, RP 8909, Propericiazine

化学信息

分子量	365.49
分子式	C₂₁H₂₃N₃OS
CAS No.	2622-26-6
Smiles	OC1CCN(CCCN2c3ccccc3Sc3ccc(cc23)C#N)CC1
密度	1.32g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 200 mg/mL (547.21 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (13.68 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7361 mL	13.6803 mL	27.3605 mL	136.8026 mL
5 mM	0.5472 mL	2.7361 mL	5.4721 mL	27.3605 mL
10 mM	0.2736 mL	1.3680 mL	2.7361 mL	13.6803 mL
20 mM	0.1368 mL	0.6840 mL	1.3680 mL	6.8401 mL
50 mM	0.0547 mL	0.2736 mL	0.5472 mL	2.7361 mL
100 mM	0.0274 mL	0.1368 mL	0.2736 mL	1.3680 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。