GJ103 sodium salt

GJ103 sodium salt 是 GJ072 的活性类似物，它是一种通读化合物 (RTC)。它已被证明可以降低水溶液的表面张力，使分子更容易在溶液中移动。它还被证明可以降低水溶液的粘度，使分子更容易在溶液中移动。此外，它还被证明可以降低水溶液的pH 值，这会对生物体的生化和生理过程产生各种影响。

产品编号 T4251Cas号 1459687-96-7

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GJ103 sodium salt

产品编号 T4251Cas号 1459687-96-7

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规格	价格	库存
1 mg	¥ 176	现货
5 mg	¥ 509	现货
10 mg	¥ 805	现货
25 mg	¥ 1,590	现货
50 mg	¥ 1,930	现货
100 mg	¥ 2,820	现货
200 mg	¥ 3,930	现货
1 mL x 10 mM (in DMSO)	¥ 398	现货

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"GJ103 sodium salt"的相关化合物库

产品介绍

生物活性

产品描述	GJ103 sodium salt is an active analog of GJ072, a read-through compound. It has been shown to reduce the surface tension of aqueous solutions, which makes it easier for molecules to move through the solution. It has also been shown to reduce the viscosity of aqueous solutions, which makes it easier for molecules to move through the solution. Additionally, it has been shown to reduce the pH of aqueous solutions, which can have a variety of effects on the biochemical and physiological processes of living organisms.
体外活性	GJ072在TGA和TAG终止密码子上激活ATM激酶，并通过FACS检测恢复了ATMpSer1981自磷酸化和SMC1pSer966跨磷酸化。GJ072对具有同源TAA突变的A-T细胞活跃，并能在经治疗的A-T细胞中诱导检测到的完整长度ATM蛋白。初步的构效关系研究产生了八个GJ072的活性类似物。一些GJ072类似物（例如GJ103、GJ106、GJ109和GJ111）通过FCATMpSer1981和IRIF试验，在所有三个PTCs中一致显示其活性。GJ071、GJ072及其一些类似物（如GJ103）与RTC13或RTC14具有相似的读通活性，但对A-T细胞来说比RTC13和RTC14更为耐受。GJ103在高达300 μM的浓度下，不在A-T细胞中显示明显的细胞毒性。
体内活性	GJ103 sodium salt 具有水溶性，这将使我们能够通过系统给药评估其体内活性。
细胞实验	Cell proliferation assay is used to measure cytotoxicity. Cells are seeded into a flat-bottom 96-well plate, including control wells containing complete growth medium alone as blank absorbance readings. After RTC treatment (GJ103), activated-XTT Solution is added into each well, and the cells are returned to the cell culture incubator for 12-14 hours. The absorbance is measured at 480 nM with relevant 630 nM to assess nonspecific readings.

化学信息

分子量	364.36
分子式	C₁₆H₁₃N₄NaO₃S
CAS No.	1459687-96-7

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

H2O: Soluble

DMSO: 50 mg/mL (137.23 mM)

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7445 mL	13.7227 mL	27.4454 mL	137.2269 mL
5 mM	0.5489 mL	2.7445 mL	5.4891 mL	27.4454 mL
10 mM	0.2745 mL	1.3723 mL	2.7445 mL	13.7227 mL
20 mM	0.1372 mL	0.6861 mL	1.3723 mL	6.8613 mL
50 mM	0.0549 mL	0.2745 mL	0.5489 mL	2.7445 mL
100 mM	0.0274 mL	0.1372 mL	0.2745 mL	1.3723 mL