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ACY-775

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产品编号 TQ0074Cas号 1375466-18-4

ACY-775 是一种特异性有效的组蛋白脱乙酰酶 6 抑制剂,IC50值为 7.5 nM。

ACY-775
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ACY-775

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纯度: 97.67%
产品编号 TQ0074Cas号 1375466-18-4

ACY-775 是一种特异性有效的组蛋白脱乙酰酶 6 抑制剂,IC50值为 7.5 nM。

规格价格库存数量
1 mg
¥ 236
现货
5 mg
¥ 583
现货
10 mg
¥ 972
现货
25 mg
¥ 2,010
现货
50 mg
¥ 2,920
现货
100 mg
¥ 4,190
现货
200 mg
¥ 5,650
现货
1 mL x 10 mM (in DMSO)
¥ 636
现货
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产品介绍

生物活性
产品描述
ACY-775 is an effective and specific inhibitor of HDAC6 (IC50: 7.5 nM).
靶点活性
HDAC1:2123 nM, HDAC6:7.5 nM
体外活性
Upon treatment with ACY-775, a clear enhancement of the acetylation of α-tubulin is visible, while histone acetylation remains unaltered. Acetylation of α-tubulin is visualized by immunofluorescence and the intensity in the neurites of the neurons is quantified and normalized to the length of the fluorescent signal. In vehicle-treated DRG neurons, acetylated α-tubulin is already present. Upon treatment with ACY-775, the signal intensity of acetylated α-tubulin increases significantly. A significant increase in motility of mitochondria and also the total number of mitochondria within the neurites are observed compared with vehicle-treated DRG neurons. A significantly higher number of retrogradely transport mitochondria is observed in DRG neurons treated with ACY-775 compared with vehicle-treated cells [1].
体内活性
Biodistribution profiles of ACY-775 are examined after acute dosing at 5 or 50?mg/kg over 2?h. At t=30?min after acute 50?mg/kg injection, respective plasma levels of ACY-775 is 1359?ng/mL (4.1?μM). Elimination from the plasma is rapid, with a plasmatic half-life of 12?min and a concentration below 10?ng/mL after 2?h. When ACY-775 (50?mg/kg) is administered repeatedly in wild-type mice at 24?h, 4?h, and 30?min before killing, significant increases in α-tubulin acetylation are observed in all tested brain regions [2].
细胞实验
Undifferentiated RN46A-B14 cells are grown. They are treated with 2.5?μM ACY-738, ACY-775, tubastatin A, 0.6?μM TSA or vehicle (0.1% DMSO) for 4?h. Samples are processed using a histone extraction kit and quantified using protein assay [2].
动物实验
Mice are tested for immobility in the TST. At 30?min or 2?h after i.p. injection of ACY-738 (5, 50?mg/kg), ACY-775 (5, 50?mg/kg), and citalopram (0.5, 2, 20?mg/kg), a combination of the previous, or vehicle, mice are attached to the test rig and time immobile over 6?min is recorded. For open-field activity, mice are injected with ACY-738 or ACY-775 at 5, 10, or 50?mg/kg or vehicle and allowed to explore [2].
化学信息
分子量330.36
分子式C17H19FN4O2
CAS No.1375466-18-4
SmilesONC(=O)c1cnc(NC2(CCCCC2)c2cccc(F)c2)nc1
密度1.342 g/cm3 (Predicted)
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度信息
DMSO: 100 mg/mL (302.70 mM), Sonication and heating are recommended.
溶液配制表
DMSO
1mg5mg10mg50mg
1 mM3.0270 mL15.1350 mL30.2700 mL151.3500 mL
5 mM0.6054 mL3.0270 mL6.0540 mL30.2700 mL
10 mM0.3027 mL1.5135 mL3.0270 mL15.1350 mL
20 mM0.1514 mL0.7568 mL1.5135 mL7.5675 mL
50 mM0.0605 mL0.3027 mL0.6054 mL3.0270 mL
100 mM0.0303 mL0.1514 mL0.3027 mL1.5135 mL

SCI 文献

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法:
TargetMol | Animal experiments比如您的给药剂量是 10 mg/kg ,每只动物体重 20 g ,给药体积 100 μLTargetMol | Animal experiments 一共给药动物 10 只 ,您使用的配方为 5% TargetMol | reagent DMSO+ 30%PEG300+ 5%Tween 80 + 60% ddH2O. 那么您的工作液浓度为 2 mg/mL
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent ( 母液浓度为 40 mg/mL ), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:50μLDMSOTargetMol | reagent 母液,添加 300 μLPEG300TargetMol | reagent 混匀澄清,再加 50μLTween 80, 混匀澄清,再加 600μLddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。

1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
%Tween 80
%ddH2O

剂量转换

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