CP-10

Name: CP-10
Brand: TargetMol
SKU: T13627
Price: 179 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T13627Cas号 2366268-80-4

CP-10 is a PROTAC with highly selective and remarkable CDK6 degradation (DC50: 2.1 nM). It inhibits the proliferation of several hematopoietic cancer cells including multiple myeloma and can degrade mutated and overexpressed CDK6.

CP-10

还可以

产品编号 T13627Cas号 2366268-80-4

规格	价格	库存
5 mg	¥ 7,320	期货
10 mg	¥ 10,300	期货
50 mg	¥ 21,900	期货
100 mg	询价	期货
200 mg	询价	期货
1 mL x 10 mM (in DMSO)	¥ 10,225	期货

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产品介绍

生物活性

产品描述	CP-10 is a PROTAC with highly selective and remarkable CDK6 degradation (DC50: 2.1 nM). It inhibits the proliferation of several hematopoietic cancer cells including multiple myeloma and can degrade mutated and overexpressed CDK6.
靶点活性	CDK6:2.1 nM (Dc50), Cereblon:
体外活性	In human glioblastoma U251 cells, CP-10 induces nearly 72% degradation of CDK6 at 10 nM and 89% at 100 nM. The degradation of CDK4 induced by CP-10 is far weaker than that of CDK6 (DC50: 50-80 fold). CP-10 displays a cell inhibition potential in mantle cell lymphoma cells (in Mino, IC50≈8 nM) and multiple myeloma cell MM.1S (IC50≈10 nM).

化学信息

分子量	871.94
分子式	C₄₄H₄₉N₁₃O₇
CAS No.	2366268-80-4
密度	1.55 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 200 mg/mL (229.37 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1469 mL	5.7343 mL	11.4687 mL	57.3434 mL
5 mM	0.2294 mL	1.1469 mL	2.2937 mL	11.4687 mL
10 mM	0.1147 mL	0.5734 mL	1.1469 mL	5.7343 mL
20 mM	0.0573 mL	0.2867 mL	0.5734 mL	2.8672 mL
50 mM	0.0229 mL	0.1147 mL	0.2294 mL	1.1469 mL
100 mM	0.0115 mL	0.0573 mL	0.1147 mL	0.5734 mL