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Search Results for " cdk6 "

Targets Recommended: Others

71

抑制剂 & 化合物

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同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T40047	CDK6/9-IN-1 CDK6/9-IN-1	Others	Others
	CDK6/9-IN-1 (compound 66) is a potent dual inhibitor of CDK 6 and CDK 9 that can be administered orally. It exhibits inhibitory activity with IC 50 values of 40.5 nM and 39.5 nM against CDK6 and CDK9, respectively.
T18515	Palbociclib-propargyl PROTAC CDK6 ligand 1	Others	Others
	Palbociclib-propargyl, a PROTAC ligand targeting the protein CDK6, connects to the CRBN ligand through a PEG linker to form PROTAC CP-10. CP-10 exhibits a potent DC50 value of 2.1 nM against CDK6[1].
T63071	CDK6/PIM1-IN-1	Others	Others
	CDK6/PIM1-IN-1 是一种平衡的、有效的、双重 CDK6 (IC50: 39 nM) 和 PIM1 (IC50: 88 nM) 抑制剂。CDK6/PIM1-IN-1 对 CDK4 表现出抑制作用，其 IC50 值为 3.6 nM。CDK6/PIM1-IN-1 能够明显抑制急性髓系白血病 (AML) 细胞增殖，将细胞周期阻滞在 G1 期并诱导细胞凋亡。CDK6/PIM1-IN-1 表现出抗 AML 活性。
T36694	XY028-140 XY028-140	CDK; PROTACs	Cell Cycle/Checkpoint; PROTAC
	XY028-140 是一种特异性 CDK4/CDK6 降解，抑制 CDK4/6 在癌细胞中的表达和活性。 XY028-140 是一种 PROTAC，由 Cereblon 配体和 CDK 配体相连接。
T8762	SW106065 SW-106065	Apoptosis	Apoptosis
	SW106065 是一种恶性外周神经鞘瘤（MPNST）细胞凋亡诱导剂。它抑制 sMPNST 和其他 MPNST 模型的 ATP 消耗，EC50 为 1 µM。
T6920	ON123300	FGFR; c-RET; JAK; CDK; PDGFR; Src; AMPK	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
	ON123300 是一种可透过血脑屏障的多激酶抑制剂，作用于 CDK4、CDK6、Ark5、PDGFRβ、FGFR1、RET 和 Fyn，IC50值为3.9、9.82、5、26、26、9.2和11 nM。它在脑肿瘤中抑制 Akt 磷酸化及激活 Erk。
T10736	CDK4/6-IN-2	CDK	Cell Cycle/Checkpoint
	CDK4/6-IN-2 是一种CDK4和CDK6抑制剂，IC50分别为 2.7 和 16 nM。
T39957	CDK4/6-IN-6	CDK	Cell Cycle/Checkpoint
	CDK4/6-IN-6 是CDK4/CDK6的有效抑制剂，结合CDK4/Cyclin D1 和 CDK6/Cyclin D3 的 Ki 为 0.6 nM 和 13.9 nM。
T11345L	Lerociclib dihydrochloride G1T38 dihydrochloride	CDK	Cell Cycle/Checkpoint
	Lerociclib dihydrochloride (G1T38 dihydrochloride) 是一种有效的选择性CDK4/CDK6抑制剂，抑制CDK6/CyclinD3和CDK4/CyclinD1，IC50值分别为 2 nM 和 1 nM。
T3111	Abemaciclib methanesulfonate abemaciclib mesylate,LY2835219,LY2835219 mesylate,LY2835219 (methanesulfonate)	CDK	Cell Cycle/Checkpoint
	Abemaciclib methanesulfonate (LY2835219) 是一种选择性的CDK4/6抑制剂，能够抑制 CDK4/CDK6 的活性，IC50分别为 2 nM 和 10 nM。
T13202	Trilaciclib hydrochloride G1T28 hydrochloride	CDK	Cell Cycle/Checkpoint
	Trilaciclib hydrochloride (G1T28 hydrochloride) 是一种CDK4/6的抑制剂，对 CDK4 和 CDK6 的IC50值分别为 1 nM 和 4 nM。
T15335	FN-1501	FLT; CDK	Angiogenesis; Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors
	FN-1501 是一种有效的 FLT3 和 CDK 抑制剂，具有抗肿瘤的活性，对 CDK2/cyclin A、CDK4/cyclin D1、CDK6/cyclin D1 和 FLT3 的 IC50值分别为 2.47、0.85、1.96 和 0.28 nM。
T8463	PF-06873600	CDK	Cell Cycle/Checkpoint
	PF-06873600 是一种选择性和口服生物可利用的细胞周期蛋白依赖性激酶 (CDK) 抑制剂（CDK2、CDK4 和 CDK6，Ki 分别为 0.09 nM、0.13 nM 和 0.16 nM），具有潜在的抗肿瘤活性。
T10220	LSN2839567 Abemaciclib metabolite M2	CDK	Cell Cycle/Checkpoint
	LSN2839567 (Abemaciclib metabolite M2) 是 Abemaciclib 的活性代谢物，是一种强效的 CDK4 和 CDK6 抑制剂（IC50s：1-3 nM），具有抗癌活性。LSN2839567 抑制 CDK9。LSN2839567 以浓度依赖性方式抑制细胞生长和细胞周期进程，可用于研究乳腺癌和肺癌。
T1785	Palbociclib PD 0332991,帕博西尼,帕布昔利布	CDK	Cell Cycle/Checkpoint
	Palbociclib (PD 0332991) 是一种 CDK 抑制剂，抑制 CDK4 和 CDK6 (IC50=11/16 nM)，具有口服活性。Palbociclib 具有抗肿瘤活性，有用于 ER 阳性和 HER2 阴性乳腺癌的研究潜力。
T74710	YX-2-107	CDK; PROTACs	Cell Cycle/Checkpoint; PROTAC
	YX-2-107 是一种具有选择性和高效性的降解 CDK6 的 PROTAC ，IC50 值为 4.4 nM。YX-2-107 在体外对 RB 磷酸化和 FOXM1 表达有抑制作用，对大鼠体内 Ph+ ALL 的发展有抑制作用。YX-2-107 可用于预防和治疗 Ph 染色体阳性 (Ph+) 急性淋巴细胞白血病 (ALL)。
T5395	BSJ-03-123	CDK; PROTACs	Cell Cycle/Checkpoint; PROTAC
	BSJ-03-123是一种有效的 CDK6 选择性小分子降解剂，是由 Cereblon 配体和 CDK 配体相连的 PROTAC。
T6837	Flavopiridol L868275,Alvocidib,夫拉平度,NSC 649890 HCl,HMR-1275	Apoptosis; HIV Protease; CDK; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; Microbiology/Virology; Proteases/Proteasome
	Flavopiridol (Alvocidib) 是一种广谱CDK 竞争型抑制剂，抑制 CDK1，CDK2，CDK4的IC50分别为30，170，100 nM。
T10745	CDK9-IN-7	CDK	Cell Cycle/Checkpoint
	CDK9-IN-7 (compound 21e) 是一种高效选择性的，具有口服活性的 CDK9/cyclin T 抑制剂 (IC50=11 nM)，与抑制其他 CDK 相比更有效 (CDK4/cyclinD=148 nM; CDK6/cyclinD=145 nM)。CDK9-IN-7 具有抗癌活性并没有明显的毒性。CDK9-IN-7 诱导非小细胞肺癌 (NSCLC) 细胞凋亡，在 G2 期阻滞细胞周期，并具有抑制非小细胞肺癌干细胞特性。
T21720	GP-82996 Cdk4/6 Inhibitor IV,CINK4	CDK	Cell Cycle/Checkpoint
	GP-82996 (CINK4) (CINK4) 是 CDK4/6的药理学抑制剂。GP-82996 对 CDK4/cyclin D1、CDK6/cyclin D1 和 Cdk5/p35 的 IC50s 分别为 1.5、5.6 和 25 μM。GP-82996 诱导肿瘤细胞 U2OS 的凋亡，可用于癌症研究。
T6049	SNS-032 SNS032,BMS-387032	Apoptosis; GSK-3; CDK	Apoptosis; Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells
	SNS-032 (BMS-387032) 是选择性的CDK2/7/9有效抑制剂，IC50值分别为 48 nM/62 nM/4 nM。它有抗肿瘤作用。
T2506	AZD-5438 AZD5438	CDK	Cell Cycle/Checkpoint
	AZD-5438 有效抑制 CDK1,CDK2,CDK9，IC50值分别为 16 nM, 6 nM, 20 nM，但它对 GSK3β，CDK5，CDK6 的抑制作用较弱。
T1778	AT7519 Hydrochloride AT7519 HCl,AT 7519 hydrochloride salt	Apoptosis; GSK-3; CDK	Apoptosis; Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells
	AT7519 Hydrochloride (AT7519 HCl) 是一种多CDK 抑制剂，对 CDK1、CDK2、CDK4-CDK6 以及 CDK9 的IC50值分别为 210、47、100、13、170 和 <10 nM。
T6205	AT7519	Apoptosis; GSK-3; CDK	Apoptosis; Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells
	AT7519 是一种CDK 抑制剂，对 CDK1，CDK2，CDK4-CDK6 以及 CDK9 的IC50值分别为 210，47，100，13，170 和 <10 nM。
T2378	RGB-286638 free base	GSK-3; MEK; JAK; CDK	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; MAPK; PI3K/Akt/mTOR signaling; Stem Cells
	RGB-286638 free base 是一种新型 CDK 抑制剂，抑制cyclin T1-CDK9、cyclin B1-CDK1、cyclin E-CDK2、cyclin D1-CDK4、cyclin E-CDK3和p35-CDK5活性，IC50分别为 1、2、3、4、5 和 5 nM。它也抑制 GSK-3β、TAK1、Jak2 和 MEK1，IC50值分别为 3、5、50和 54 nM。
T6239	Palbociclib monohydrochloride PD 0332991 hydrochloride,Palbociclib hydrochloride,帕布昔利布盐酸盐,Palbociclib (PD-0332991) HCl	CDK	Cell Cycle/Checkpoint
	Palbociclib monohydrochloride (PD 0332991 hydrochloride) 是一种口服的细胞周期蛋白依赖性激酶 (CDK) 抑制剂，具有潜在的抗肿瘤活性。它抑制 CDK4和 CDK6，IC50分别为11 nM，16 nM。它有用于 ER 阳性和 HER2 阴性乳腺癌的研究潜力。
T13202L	Trilaciclib G1T28	CDK	Cell Cycle/Checkpoint
	Trilaciclib is an inhibitor of CDK4/6 (IC50s: 1 nM and 4 nM for CDK4 and CDK6, respectively).
T13627	CP-10	CDK; PROTACs	Cell Cycle/Checkpoint; PROTAC
	CP-10 is a PROTAC with highly selective and remarkable CDK6 degradation (DC50: 2.1 nM). It inhibits the proliferation of several hematopoietic cancer cells including multiple myeloma and can degrade mutated and overexpressed CDK6.
T10735	CDK4/6/1 Inhibitor Crozbaciclib	CDK	Cell Cycle/Checkpoint
	CDK4/6/1 Inhibitor (Crozbaciclib) 是一种 CDK4/6 抑制剂 (IC50s: 3 and 1 nM). CDK4/6抑制剂是一类用于治疗一些类型的激素受体阳性、her2阴性乳腺癌的化合物，可阻断了乳腺癌细胞分裂和繁殖的过程。
T10737	CDK4/6-IN-3	CDK	Cell Cycle/Checkpoint
	CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor (Kis: <0.3 nM and 2.2 nM) used for the treatment of glioblastoma. It inhibits CDK1 with a Ki of 110 nM.
T15732	Ribociclib succinate LEE011 琥珀酸盐,瑞博西尼琥珀酸盐,LEE011 succinate	CDK	Cell Cycle/Checkpoint
	Ribociclib succinate (LEE011 succinate) 是一种高度特异性的CDK4/6抑制剂，IC50值分别为 10 nM 和 39 nM。它对细胞周期蛋白 B/CDK1 复合物的效力低 1000 倍。
T11345	Lerociclib G1T38	CDK	Cell Cycle/Checkpoint
	Lerociclib (G1T38) is a potent and selective inhibitor of CDK4/6, with IC50s of 2nM, 1 nM for CDK6/CyclinD3 and CDK4/CyclinD1, respectively.
T35477	BSJ-Bump	Others	Others
	Negative control for BSJ-03-123 . Displays binding and no degradation of Cdk6 in vitro. Brand et al (2019) Homolog-selective degradation as a strategy to probe the function of CDK6 in AML. Cell Chem.Biol. 26 300 PMID:30595531
T22590	AT7519 TFA AT7519 trifluoroacetate	Others	Others
	AT7519 is a kinase inhibitor (IC50: 0.19, 0.044, 0.51, 0.067, 0.66 and 0.018 μM for CDK1/cyclinB, CDK2/CyclinA, CDK2/Cyclin E, CDk4/CyclinD1, CDK6/Cyclin D3, CDk5/p35).
T39956	CDK4/6-IN-5 CDK4/6-IN-5	Others	Others
	CDK4/6-IN-5 is a highly effective inhibitor of CDK4 and CDK6, with Ki values of 0.2 and 4.4 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively (WO2019207463A1, example A93).
T9636	Dalpiciclib SHR-6390	CDK	Cell Cycle/Checkpoint
	Dalpiciclib (SHR-6390) 是一种高选择性、口服生物利用度和相当效力的 CDK4 和 CKD6 抑制剂，IC50 分别为 12.4 nM 和 9.9 nM。它通过抑制磷酸化 Rb 蛋白和诱导 G1 细胞周期阻滞在食管鳞状细胞癌中发挥有效的抗肿瘤活性。
T2381	Abemaciclib CDK4/6 dual inhibitor,LY2835219	CDK	Cell Cycle/Checkpoint
	Abemaciclib (LY2835219) 是一种 CDK4/6 的双重抑制剂 (IC50=2/10 nM)，具有选择性和特异性。Abemaciclib 具有抗肿瘤活性，被用于治疗晚期或转移性乳腺癌。
T17904	Pomalidomide-PEG1-C2-N3 E3 ligase Ligand-Linker Conjugates 50,Cereblon Ligand-Linker Conjugates 13	Others	Others
	Pomalidomide-PEG1-C2-N3 is a compound that has been synthesized as a conjugate of an E3 ligase ligand-linker. This compound incorporates the cereblon ligand based on Pomalidomide and a 1-unit PEG linker, which are commonly used in PROTAC technology. Utilizing Pomalidomide-PEG1-C2-N3, it is possible to design a selective CDK6 PROTAC degrader known as CP-10. CP-10 effectively induces the degradation of CDK6, displaying a DC50 value of 2.1 nM[1].
TP2133	[Ala92]-p16 (84-103)
	Peptide derived from the tumor suppressor protein p16; inhibits cyclin-dependent kinase-4 (cdk4)/cyclin D1 (IC50 ~ 1.5 μM) and binds to cdk6.
T61378	Anticancer agent 29	Others	Others
	Anticancer agent 29 (Compd E/Z-6f) exhibits potent anticancer activity, as indicated by IC50 values of 0.054 μM, 0.127 μM, 0.129 μM, and 0.396 μM for CDK2, CDK1, CDK4, and CDK6, respectively [1].
T72507	Palbociclib orotate PD 0332991 orotate	CDK	Cell Cycle/Checkpoint
	Palbociclib (PD 0332991) orotate 是一种口服活性的CDK4和CDK6选择性抑制剂，其IC50值分别为11 nM和16 nM。该化合物对癌细胞展示出抗增殖效果，并促使细胞周期处于阻滞状态。该药物适用于HR阳性、HER2阴性乳腺癌以及肝细胞癌的研究。
T78130	N-Methyl Palbociclib	Drug Metabolite	Metabolism
	N-MethylPalbociclib是一种Palbociclib的杂质。Palbociclib（PD 0332991）是一种口服活性的CDK4和CDK6抑制剂。
T61892	CDK4/6-IN-8	Others	Others
	CDK4/6-IN-8 (Compound 7p) 是选择性的CDK4（IC50= 5.01 nM）和CDK6（IC50= 3.97 nM）抑制剂。
T64244	CDK4/6-IN-10	Others	Others
	CDK4/6-IN-10 是一种选择性的、有效的、口服具有活力的 CDK4 (IC50: 22 nM) 和 CDK6 (IC50: 10 nM) 抑制剂，具有抗肿瘤效果。CDK4/6-IN-10 具有潜力进行多发性骨髓瘤 (MM) 的研究。
T67780	AM5992 CDK4/6-IN-16	CDK	Cell Cycle/Checkpoint
	AM5992 (化合物195) 是有效的CDK4和CDK6抑制剂（CDK4，IC50=0.013μM）。AM5992可用于CDK4介导的疾病的研究。
T35476	BSJ-04-132	PROTACs	PROTAC
	Selective Cdk4 degrader. Degrades Cdk4 in Molt-4 cells, with no effect on Cdk6 levels. Displays cereblon-dependent degradation. Jiang et al (2019) Development of dual and selective degraders of cyclin-dependent kinases 4 and 6. Angew.Chem.Int.Ed.Engl. 58 6321 PMID:30802347
T60328	CDK4/6-IN-12	Others	Others
	CDK4/6-IN-12 是一种有效的细胞周期蛋白依赖性激酶 4/6 抑制剂。CDK4/6-IN-12 对 CDK4 和 CDK6 具有抑制活性，IC50值分别为 592.3 nM 和 3090 nM。 CDK4/6-IN-12 可用于癌症的研究。
T63362	Ulecaciclib	Others	Others
	Ulecaciclib 是口服具有活力的、能够透过血脑屏障的、表现出良好的药代动力学特征的细胞周期蛋白依赖激酶 (CDK) 抑制剂，对CDKs 的ki 为 0.62 μM (CDK2/Cyclin A)、3 nM (CDK6/Cyclin D3) 、0.2 nM (CDK4/Cyclin D1)和 0.63 μM (CDK7/Cyclin H)。
T63634	Palbociclib dihydrochloride	Others	Others
	Palbociclib (PD 0332991) dihydrochloride 是口服具有活力的、选择性的 CDK4 (IC50: 11 nM) 和 CDK6 (IC50: 16 nM) 抑制剂。Palbociclib dihydrochloride 对癌细胞具有抗增殖活性，并阻滞细胞周期，能够用于 HR 阳性和 HER2 阴性乳腺癌，以及肝细胞癌的相关研究。
T79014	QR-6401	CDK	Cell Cycle/Checkpoint
	QR-6401是一种口服、选择性的大环CDK2抑制剂，其IC50分别针对CDK2/E1、CDK9/T1、CDK1/A2、CDK6/D3和CDK4/D1为0.37、10、22、34及45nM。在OVCAR3卵巢癌异种移植模型中，QR-6401表现出显著的抗肿瘤活性，显示出其作为癌症研究工具的潜能。

化合物

Cat.No: T40047

Synonym: CDK6/9-IN-1

Target: Others

Palbociclib-propargyl

Cat.No: T18515

Synonym: PROTAC CDK6 ligand 1

Target: Others

CDK6/PIM1-IN-1

Cat.No: T63071

Target: Others

Cat.No: T36694

Synonym: XY028-140

Target: CDK, PROTACs

Cat.No: T8762

Synonym: SW-106065

Target: Apoptosis

Cat.No: T6920

Target: FGFR, c-RET, JAK, CDK, PDGFR, Src, AMPK

Cat.No: T10736

Target: CDK

Cat.No: T39957

Target: CDK

Lerociclib dihydrochloride

Cat.No: T11345L

Synonym: G1T38 dihydrochloride

Target: CDK

Abemaciclib methanesulfonate

Cat.No: T3111

Synonym: abemaciclib mesylate,LY2835219,LY2835219 mesylate,LY2835219 (methanesulfonate)

Target: CDK

Trilaciclib hydrochloride

Cat.No: T13202

Synonym: G1T28 hydrochloride

Target: CDK

Cat.No: T15335

Target: FLT, CDK

Cat.No: T8463

Target: CDK

Cat.No: T10220

Synonym: Abemaciclib metabolite M2

Target: CDK

Cat.No: T1785

Synonym: PD 0332991,帕博西尼,帕布昔利布

Target: CDK

Cat.No: T74710

Target: CDK, PROTACs

Cat.No: T5395

Target: CDK, PROTACs

Cat.No: T6837

Synonym: L868275,Alvocidib,夫拉平度,NSC 649890 HCl,HMR-1275

Target: Apoptosis, HIV Protease, CDK, Autophagy

Cat.No: T10745

Target: CDK

Cat.No: T21720

Synonym: Cdk4/6 Inhibitor IV,CINK4

Target: CDK

Cat.No: T6049

Synonym: SNS032,BMS-387032

Target: Apoptosis, GSK-3, CDK

Cat.No: T2506

Synonym: AZD5438

Target: CDK

AT7519 Hydrochloride

Cat.No: T1778

Synonym: AT7519 HCl,AT 7519 hydrochloride salt

Target: Apoptosis, GSK-3, CDK

Cat.No: T6205

Target: Apoptosis, GSK-3, CDK

RGB-286638 free base

Cat.No: T2378

Target: GSK-3, MEK, JAK, CDK

Palbociclib monohydrochloride

Cat.No: T6239

Synonym: PD 0332991 hydrochloride,Palbociclib hydrochloride,帕布昔利布盐酸盐,Palbociclib (PD-0332991) HCl

Target: CDK

Cat.No: T13202L

Synonym: G1T28

Target: CDK

Cat.No: T13627

Target: CDK, PROTACs

CDK4/6/1 Inhibitor

Cat.No: T10735

Synonym: Crozbaciclib

Target: CDK

Cat.No: T10737

Target: CDK

Ribociclib succinate

Cat.No: T15732

Synonym: LEE011 琥珀酸盐,瑞博西尼琥珀酸盐,LEE011 succinate

Target: CDK

Cat.No: T11345

Synonym: G1T38

Target: CDK

Cat.No: T35477

Target: Others

Cat.No: T22590

Synonym: AT7519 trifluoroacetate

Target: Others

Cat.No: T39956

Synonym: CDK4/6-IN-5

Target: Others

Cat.No: T9636

Synonym: SHR-6390

Target: CDK

Cat.No: T2381

Synonym: CDK4/6 dual inhibitor,LY2835219

Target: CDK

Pomalidomide-PEG1-C2-N3

Cat.No: T17904

Synonym: E3 ligase Ligand-Linker Conjugates 50,Cereblon Ligand-Linker Conjugates 13

Target: Others

[Ala92]-p16 (84-103)

Cat.No: TP2133

Anticancer agent 29

Cat.No: T61378

Target: Others

Palbociclib orotate

Cat.No: T72507

Synonym: PD 0332991 orotate

Target: CDK

N-Methyl Palbociclib

Cat.No: T78130

Target: Drug Metabolite

Cat.No: T61892

Target: Others

Cat.No: T64244

Target: Others

Cat.No: T67780

Synonym: CDK4/6-IN-16

Target: CDK

Cat.No: T35476

Target: PROTACs

Cat.No: T60328

Target: Others

Cat.No: T63362

Target: Others

Palbociclib dihydrochloride

Cat.No: T63634

Target: Others

Cat.No: T79014

Target: CDK

Cat. No.	Product Name	Target	Signaling Pathways
T16324	Nimbolide	Apoptosis; NF-κB; CDK	Apoptosis; Cell Cycle/Checkpoint; NF-κB
	Nimbolide 是源自印楝叶和花的一种三萜。它抑制CDK4/CDK6激酶活性。它抑制 NF-κB，Wnt，PI3K-Akt，MAPK 和 JAK-STAT 信号通路。它通过抑制NF-κB 而诱导肿瘤细胞凋亡。
T6S0221	Eriocitrin eriodictyol 7-rutinoside,圣草次甙,Eriodictyol-7-O-Rutinoside,Eriodictioside,圣草次甙；圣草次苷,Eriodictyol glycoside	Apoptosis; Carbonic Anhydrase	Apoptosis; Metabolism
	Eriocitrin (Eriodictyol-7-O-Rutinoside) 是从柠檬中分离出来的一种黄酮类天然产物，是强效的抗氧化剂。它通过激活线粒体涉及的内在信号传导途径来触发细胞凋亡。它通过上调 p53、cyclin A、cyclin D3 和 CDK6 使 S 期细胞周期停滞，从而抑制肝癌细胞的增殖。

天然产物

Cat.No: T16324

Target: Apoptosis, NF-κB, CDK

Cat.No: T6S0221

Synonym: eriodictyol 7-rutinoside,圣草次甙,Eriodictyol-7-O-Rutinoside,Eriodictioside,圣草次甙；圣草次苷,Eriodictyol glycoside

Target: Apoptosis, Carbonic Anhydrase

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04548	CDK4 Protein, Human, Recombinant (GST) CMM3,PSK-J3,cyclin-dependent kinase 4	Human	Baculovirus Insect Cells
	CDK4 is a member of the Ser/Thr protein kinase family. It is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of CDK4 is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). CDK4 was shown to be responsible for the phosphorylation of retinoblastoma gene product. CDK4 is the ser...
TMPY-03599	RPRD1B Protein, Human, Recombinant (His) C20orf77,regulation of nuclear pre-mRNA domain containing 1B...	Human	HEK293 Cells
	RPRD1B, together with RPRD1A, can accompany RNAP II from promoter regions to 3'-untranslated regions during transcription in vivo, predominantly interact with phosphorylated RNAP II, and can reduce CTD S5- and S7-phosphorylated RNAP II at target gene promoters. RNA polymerase II C-terminal domain (CTD) phosphorylation is important for various transcription-related processes. RPRD1B is a transcriptional regulator that enhances expression of CCND1. It also enhances the transcription of a number of...
TMPJ-00963	CDKN2C Protein, Human, Recombinant (His) Cyclin-Dependent Kinase 4 Inhibitor C,p18-INK4c,CDK...	Human	E. coli
	Cyclin-Dependent Kinase 4 Inhibitor C (CDKN2C) is a member of the INK4 family of cyclin dependent kinase inhibitors. CDKN2C contains 4 ANK repeats and interacts with CDK4 or CDK6. Highest levels of CDKN2C can be found in skeletal muscle, pancreas, and heart. CDKN2C inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB and prevent the activation of the CDK kinases. Studies have been shown the roles of CDKN2C gene in regulating spermatogenesis,...
TMPJ-00936	CCND2 Protein, Human, Recombinant (His) G1/S-specific cyclin-D2,CCND2	Human	E. coli
	CCND2，also known as G1/S-specific cyclin-D2，is a member of the highly conserved cyclin family. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclins function as regulators of CDK kinases. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. CCND2 is involved in a number of fundamental biological processes such ...

重组蛋白

CDK4 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04548

Species: Human

Expression System: Baculovirus Insect Cells

RPRD1B Protein, Human, Recombinant (His)

Cat.No: TMPY-03599

Species: Human

Expression System: HEK293 Cells

CDKN2C Protein, Human, Recombinant (His)

Cat.No: TMPJ-00963

Species: Human

Expression System: E. coli

CCND2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00936

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T12355	Palbociclib-d8 PD 0332991 D8,Palbociclib D8	CDK	Cell Cycle/Checkpoint
	Palbociclib D8 is a deuterium labeled Palbociclib. Palbociclib is a selective and orally active inhibitor of CDK4 and CDK6 (IC50s of 11 and 16 nM, respectively).
TMIJ-0275	Abemaciclib-d8
	Abemaciclib-d8 是 Abemaciclib 的氘代化合物。Abemaciclib 的 CAS 号为 1231929-97-7。Abemaciclib 是一种选择性的CDK4/6抑制剂，能够抑制 CDK4/CDK6 的活性，IC50分别为 2 nM 和 10 nM。

同位素标记化合物

Cat.No: T12355

Synonym: PD 0332991 D8,Palbociclib D8

Target: CDK

Cat.No: TMIJ-0275

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