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Search Results for " slow-binding "

Targets Recommended: Cysteine Protease Parasite

19

抑制剂 & 化合物

1

天然产物

4

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T12909	SID 26681509	Cysteine Protease; Parasite	Microbiology/Virology; Proteases/Proteasome
	SID 26681509 是可逆的，竞争性的人组织蛋白酶 L 选择性抑制剂，IC50为 56 nM。它抑制Plasmodium falciparum 的体外繁殖，IC50为15.4 μM，抑制Leishmania major，IC5012.5 μM。
T11831	LDN-27219	Others	Others
	LDN-27219 是一种人组织型转谷氨酰胺酶抑制剂(IC50:600 nM)。
T25372	EMD57033 EMD-57033,(+)-EMD 57033,EMD 57033	Calcium Channel; Carbonic Anhydrase	Membrane transporter/Ion channel; Metabolism
	EMD57033是一种心脏肌钙蛋白C（cTnC）激活剂，是一种显性的Ca2+增敏剂。EMD57033通过与心脏/慢速骨骼肌钙蛋白C 异构体结合从而发挥促进心脏收缩的功能。
T3193	Pimelic diphenylamide 106 Histone Deacetylase Inhibitor VII,TC-H 106,RGFA-8	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Pimelic diphenylamide 106 (RGFA-8) 是一种缓慢和紧密结合的I 类HDAC 抑制剂，对HDAC1、 2和3的IC50值分别150、760和370 nM。
T61111	UCB-5307	TNF	Apoptosis
	UCB-5307 是一种小分子化合物，可在体外抑制 TNFR1 信号转导和下游功能。人 TNFα 的 KD 为 9 nM。 TNF 直接通过缓慢的结合动力学结合，KD = 6 nM。 UCB-5307 可以通过预制的 hTNF/hTNFR1 复合物。
T6707	Tiotropium Bromide hydrate BA-679 BR hydrate,BA 679BR,噻托溴铵一水合物	AChR	Neuroscience
	Tiotropium Bromide hydrate (BA-679 BR hydrate) 是长效的毒蕈碱受体拮抗剂，可用于治疗慢性阻塞性气道疾病 (COPD)。
T28798	SL-25.1188 SL25.1188	Others	Others
	SL-25.1188 is a monoamine oxidase B (MAO-B) inhibitor. SL-25.1188 is characterized by reversible binding, high brain uptake, and very slow plasma metabolism in vivo.
T38730	Ara-F-NAD+	Others	Others
	Ara-F-NAD+, an arabino analogue of NAD + , is a potent, slow-binding CD38 NADase inhibitor, with a K i of 169 nM.
T24348	L 708286 L708286,L-708286,DFKi	Others	Others
	L 708286 is an agent of peptide-based phenethylcarbamoyldifluoromethylene. It is a slow-binding inhibitor of human leucocyte elastase (HLE).
T15285	FK706	Serine Protease	Proteases/Proteasome
	FK706 is a slow-binding and competitive human neutrophil elastase inhibitor (IC50: 83 nM; Ki: 4.2 nM). FK706 also inhibits mouse neutrophil elastase and porcine pancreatic elastase (IC50s: 22 nM and 100 nM, respectively). FK706 has an anti-inflammatory ef
T28245	ONO-0300302 ONO 0300302	Others	Others
	ONO-0300302 is a slow tight binding LPA1 antagonist (IC50: 0.16 nM) used to treat Benign Prostatic Hyperplasia. ONO-0300302 inhibits significantly an LPA-induced increase of intraurethral pressure (IUP) in rat (3 mg/kg, p.o.) and dog (1 mg/kg, p.o.) over
T74032	Ara-F-NAD+ sodium	Others	Others
	Ara-F-NAD+ sodium 是一种 NAD+的 arabino 类似物。Ara-F-NAD+ sodium 是一种有效的、可逆的、缓慢结合的CD38NADase 抑制剂。
T29073	UR-2922 UR 2922	Others	Others
	UR-2922 is an oral antagonist of platelet GPIIb/IIIa. UR-2922 possessed a high affinity for the human platelet receptor (K(d) <1 nM) and a slow dissociation rate (k(off)= 90 min) in vitro. UR-2922 induced no ligand-induced binding sites (LIBS) expression
T73051	Leritrelvir RAY1216	SARS-CoV	Microbiology/Virology
	Leritrelvir (RAY1216)，一种口服活性SARS-CoV-2主要蛋白酶慢紧抑制剂，其Ki值为8.6 nM。
T38050	CP-609754	Transferase	Metabolism
	CP-609754 是高效的、可逆的法尼基转移酶抑制剂，对重组人 H-Ras 和重组 K-Ras 法尼基化的 IC50分别为 0.57 ng/mL 和 46 ng/mL。CP-609754有潜在的抗癌作用。
T21681	AACOCF3 Arachidonyl trifluoromethyl ketone,Arachidonyltrifluoromethane	Phospholipase	Metabolism
	AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeable trifluoromethyl ketone analog of arachidonic acid. It is a potent and selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2). By blocking the production of arachidonate and 12-hydroxyeicosatetraenoic acid in calcium ionophore-challenged platelets, AACOCF3 hinders their synthesis. Moreover, AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets. Given its diverse applications, AACOCF3 ...
T37492	11-trans Leukotriene C4 11-trans Leukotriene C4	Others	Others
	11-trans Leukotriene C4 (11-trans LTC4) is a C-11 double bond isomer of LTC4. LTC4 undergoes slow temperature-dependent isomerization to 11-trans LTC4 during storage. 11-trans LTC4 is produced in smaller amounts relative to LTC4 in ionophore-stimulated HMC-1 cells (a human mast cell line) and equine eosinophils, but not in human neutrophils or RBL-1 cells. It is nearly equipotent with LTC4 for contraction of guinea pig parenchymal and ileum. In a radioligand binding assay using guinea pig ileum ...
T71000	RO-5328673	Others	Others
	RO-5328673 is a dual NK2/NK3 antagonist. O5328673. [(3)H]RO5328673 bound to a single saturable site on hNK2, hNK3 and gpNK3 with high-affinity. RO5328673 acted as an insurmountable antagonist at both human and guinea-pig NK3 receptors in the [(3)H]IP accumulation assay. In binding kinetic analyses, [(3)H]RO5328673 had fast association and dissociation rates at hNK2 while it had a fast association rate and a remarkably slow dissociation rate at gp and hNK3. In electrophysiological recordings of g...
T71618	Oxocarbazate	Others	Others
	Oxocarbazate, also known as CID23631927, is an inhibitor of human cathepsin L. In the cathepsin L inhibition assay, The oxocarbazate caused a time-dependent 17-fold drop in IC50 from 6.9 nM (no preincubation) to 0.4 nM (4-h preincubation). Slowly reversible inhibition was demonstrated in a dilution assay. CID23631927 demonstrate activity in blocking both SARS-CoV (IC50 = 273 nM) and Ebola virus (IC50 = 193 nM) entry into human embryonic. CID 23631927 was a subnanomolar, slow-binding, reversible...

化合物

Cat.No: T12909

Target: Cysteine Protease, Parasite

Cat.No: T11831

Target: Others

Cat.No: T25372

Synonym: EMD-57033,(+)-EMD 57033,EMD 57033

Target: Calcium Channel, Carbonic Anhydrase

Pimelic diphenylamide 106

Cat.No: T3193

Synonym: Histone Deacetylase Inhibitor VII,TC-H 106,RGFA-8

Target: HDAC

Cat.No: T61111

Target: TNF

Tiotropium Bromide hydrate

Cat.No: T6707

Synonym: BA-679 BR hydrate,BA 679BR,噻托溴铵一水合物

Target: AChR

Cat.No: T28798

Synonym: SL25.1188

Target: Others

Cat.No: T38730

Target: Others

Cat.No: T24348

Synonym: L708286,L-708286,DFKi

Target: Others

Cat.No: T15285

Target: Serine Protease

Cat.No: T28245

Synonym: ONO 0300302

Target: Others

Ara-F-NAD+ sodium

Cat.No: T74032

Target: Others

Cat.No: T29073

Synonym: UR 2922

Target: Others

Cat.No: T73051

Synonym: RAY1216

Target: SARS-CoV

Cat.No: T38050

Target: Transferase

Cat.No: T21681

Synonym: Arachidonyl trifluoromethyl ketone,Arachidonyltrifluoromethane

Target: Phospholipase

11-trans Leukotriene C4

Cat.No: T37492

Synonym: 11-trans Leukotriene C4

Target: Others

Cat.No: T71000

Target: Others

Cat.No: T71618

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN3540	Broussonin C	Tyrosinase; Antifection	Microbiology/Virology; Proteases/Proteasome
	Broussonin C and broussin are antifungal compounds. Broussonin C exerts simple reversible slow-binding inhibition against diphenolase.

天然产物

Cat.No: TN3540

Target: Tyrosinase, Antifection

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-03070	TAP Protein, Ornithodoros moubata, Recombinant (His) Tick anticoagulant peptide	Ornithodoros moubata	P. pastoris (Yeast)
	TAP is a slow, tight-binding inhibitor of blood coagulation, specific for factor Xa.
TMPH-03071	TAP Protein, Ornithodoros moubata, Recombinant (His & Myc & SUMO) Tick anticoagulant peptide	Ornithodoros moubata	E. coli
	TAP is a slow, tight-binding inhibitor of blood coagulation, specific for factor Xa.
TMPY-03603	AHSP Protein, Human, Recombinant ERAF,alpha hemoglobin stabilizing protein,α hemoglobin stabi...	Human	E. coli
	AHSP, also known as ERAF, is a conserved mammalian erythroid protein which belongs to the AHSP family. It is expressed in blood and bone marrow. AHSP facilitates the production of Hemoglobin A by stabilizing free α-globin. It rapidly binds to ferrous α with association (k'(AHSP)) and dissociation (k(AHSP)) rate constants of ≈1 μm(-1) s(-1) and .2 s(-1), respectively, at pH 7.4 at 22 ℃. A small slow phase was observed when AHSP binds to excess ferrous αCO. This slow phase appears to be due to cis...
TMPY-01479	SPG3A Protein, Human, Recombinant (GST) HSN1D,atlastin GTPase 1,FSP1,atlastin1,GBP3,SPG3,SPG3A,AD-FS...	Human	Baculovirus Insect Cells
	Atlastin-1, also known as Spastic paraplegia 3 protein A, Guanine nucleotide-binding protein 3, GTP-binding protein 3, GBP3, ATL1 and SPG3A, is a multi-pass membrane protein which belongs to theGBP family and atlastin subfamily. ATL1 / SPG3A is expressed predominantly in the adult and fetal central nervous system. Expression of ATL1 / SPG3A in adult brain is at least 5-fold higher than in other tissues. ATL1 / SPG3A is detected predominantly in pyramidal neurons in the cerebral cortex and...

重组蛋白

TAP Protein, Ornithodoros moubata, Recombinant (His)

Cat.No: TMPH-03070

Species: Ornithodoros moubata

Expression System: P. pastoris (Yeast)

TAP Protein, Ornithodoros moubata, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-03071

Species: Ornithodoros moubata

Expression System: E. coli

AHSP Protein, Human, Recombinant

Cat.No: TMPY-03603

Species: Human

Expression System: E. coli

SPG3A Protein, Human, Recombinant (GST)

Cat.No: TMPY-01479

Species: Human

Expression System: Baculovirus Insect Cells

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