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TMPJ-00464
|
APE Protein, Human, Recombinant
APEX,Apurinic-Apyrimidinic Endonuclease 1,APEN,DNA-(Apurinic...
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Human
|
E. coli
|
|
Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases, APE1 cleaves the AP site to allow resynthesis and ligation to complete repair. APE1 stimulates the DNA binding activity of many transcription factors, which participate in cancer promotion and progression. APE1 regulates the redox state of multiple transcription factors, such as c-Jun, c-Fos, NF-kB, p53. APEN is also involved in calcium-dependent down... |
|
TMPY-00382
|
Thioredoxin/TRX Protein, Mouse, Recombinant
Txn,Txn1,thioredoxin
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Mouse
|
E. coli
|
|
Thioredoxin/TRX Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 11.7 kDa and the accession number is P10639. |
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TMPH-00739
|
Thioredoxin-1 Protein, E. coli, Recombinant (His)
Thioredoxin 1,trxA
|
E. coli
|
E. coli
|
|
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Thioredoxin-1 Protein, E. coli, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 15.7 kDa and the accession number is P0AA25. |
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TMPY-02201
|
Peroxiredoxin 6 Protein, Human, Recombinant (His)
p29,PRX,1-Cys,HEL-S-128m,peroxiredoxin 6,NSGPx,AOP2...
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Human
|
E. coli
|
|
PRDX6, a member of antioxidant protein superfamily, plays an important role in oxidative stress, catabolism of lipids and phospholipid lipisomes. Peroxiredoxin 6 (PRDX6) is involved in redox regulation of the cell and is thought to be protective against oxidant injury. Peroxiredoxin 6 (PRDX6) is a bifunctional protein with both glutathione peroxidase (GPx) and iPLA2 activities，which are concomitantly increased with the expression of PRDX6. PRDX6 promoted lung tumor growth in an in vivo allograft... |
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TMPY-02084
|
Thioredoxin 2/TRX2 Protein, Human, Recombinant (His)
MT-TRX,RP5-1119A7. 13-005,TRX2,MTRX,thioredoxin 2
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Human
|
E. coli
|
|
Thioredoxin-2, also known as TXN2, MTRX and TRX2, is a member of the thioredoxin family. Tryparedoxins (TXN) are thioredoxin-related proteins which, as trypanothione:peroxiredoxin oxidoreductases, constitute the trypanothione-dependent antioxidant defense and may also serve as substrates for ribonucleotide reductase in trypanosomatids. Thioredoxin-2 / TXN2 contains one thioredoxin domain. It is widely expressed in adult (at protein level) and fetal tissues. Human Thioredoxin-2 / TXN2 is a small ... |
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TMPH-03505
|
Glutaredoxin 4/GrxD Protein, Shigella flexneri, Recombinant (His & SUMO)
grxD,Monothiol glutaredoxin,Glutaredoxin 4
|
Shigella flexneri
|
E. coli
|
|
Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. |
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TMPH-02153
|
Sulfiredoxin-1 Protein, Human, Recombinant (His & Myc)
SRXN1,Sulfiredoxin-1
|
Human
|
E. coli
|
|
Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase. |
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TMPY-03605
|
Glutaredoxin 1/GRX1 Protein, Human, Recombinant (His)
GLRX,GRX,GRX1,glutaredoxin
|
Human
|
E. coli
|
|
Glutaredoxin-1, also known as GRX1 and GLRX, belongs to theglutaredoxin family. Glutaredoxinsare smallredoxenzymes that useglutathioneas a cofactor. Glutaredoxins are oxidized by substrates, and reduced non-enzymatically by glutathione. Glutaredoxin-1 functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. Glutaredoxin-1 exists in either a reduced or an oxidized form. Glutaredoxins function as electron carriers ... |
|
TMPH-00418
|
Rubredoxin Protein, Clostridium pasteurianum, Recombinant (His & SUMO)
Rubredoxin
|
Clostridium pasteurianum
|
E. coli
|
|
Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule. Rubredoxin Protein, Clostridium pasteurianum, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 22.0 kDa and the accession number is P00268. |
|
TMPY-02462
|
Peroxiredoxin 5 Protein, Mouse, Recombinant (His)
peroxiredoxin 5,PrxV,AOPP,Pmp20,AOEB166,Prdx6
|
Mouse
|
E. coli
|
|
Peroxiredoxin 5 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 18.5 kDa and the accession number is P99029-1. |
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TMPY-02250
|
Thioredoxin/TRX Protein, Human, Recombinant
thioredoxin,TRDX,DKFZp686B1993,MGC61975,TXN,TRX1,RP...
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Human
|
E. coli
|
|
Thioredoxin/TRX Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 11.7 kDa and the accession number is P10599. |
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TMPH-00016
|
Ferredoxin Protein, Acetoanaerobium sticklandii, Recombinant (His & Myc)
Ferredoxin
|
Acetoanaerobium sticklandii
|
E. coli
|
|
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. |
|
TMPY-05169
|
Peroxiredoxin 2 Protein, Mouse, Recombinant (His)
Torin,TPx-B,Band-8,peroxiredoxin 2,PRP,AL022839,TR,...
|
Mouse
|
Baculovirus Insect Cells
|
|
Peroxiredoxin 2 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 24.1 kDa and the accession number is Q61171. |
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TMPY-02200
|
Peroxiredoxin 2 Protein, Human, Recombinant (His)
PRP,HEL-S-2a,TSA,NKEF-B,TDPX1,PTX1,TPX1,peroxiredox...
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Human
|
Baculovirus Insect Cells
|
|
Peroxiredoxin 2 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 24 kDa and the accession number is P32119. |
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TMPY-02208
|
Peroxiredoxin 5 Protein, Human, Recombinant (His)
B166,HEL-S-55,prx-V,ACR1,PMP20,AOEB166,SBBI10,PRXV,peroxi
|
Human
|
E. coli
|
|
Peroxiredoxin 5 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 18.5 kDa and the accession number is P30044-2. |
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TMPY-02372
|
Peroxiredoxin 1 Protein, Mouse, Recombinant (His)
PAG,OSF-3,OSF3,Paga,PRDX1,Tdpx2,PrxI,TDX2,TPxA,prx1,peroxi
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Mouse
|
E. coli
|
|
Peroxiredoxin 1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 23.5 kDa and the accession number is P35700. |
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TMPY-01276
|
Peroxiredoxin 1 Protein, Human, Recombinant (His)
PAGA,peroxiredoxin 1,NKEFA,MSP23,PAG,TDPX2,PAGB,PRX...
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Human
|
E. coli
|
|
Peroxiredoxin 1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 22.9 kDa and the accession number is A0A384NPQ2. |
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TMPY-03407
|
NQO1 Protein, Human, Recombinant (His)
NAD(P)H dehydrogenase, quinone 1,NMORI,DIA4,QR1,NMOR1,DTD,DH...
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Human
|
E. coli
|
|
NQO1 gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. NQO1 forms homodimers and reduces quinones to hydroquinones. NQO1's enzymatic activity prevents the one-electron reduction of quinones that results in the production of radical species. Mutations in the NQO1 gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered ex... |
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TMPH-02198
|
TXNRD2 Protein, Human, Recombinant (His & SUMO)
TR-beta,Thioredoxin reductase 2, mitochondrial,Thio...
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Human
|
E. coli
|
|
Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis. Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling. |
|
TMPY-04022
|
BOLA1 Protein, Human, Recombinant (His)
CGI-143,bolA family member 1
|
Human
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E. coli
|
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BOLA1 is a mitochondrial protein that counterbalances the effect of L-buthionine-(S,R)-sulfoximine (BSO)-induced glutathione (GSH) depletion on the mitochondrial thiol redox potential. Furthermore, overexpression of BOLA1 nullifies the effect of BSO and S-nitrosocysteine on mitochondrial morphology. Conversely, knockdown of the BOLA1 gene increases the oxidation of mitochondrial thiol groups. Supporting a role of BOLA1 in controlling the mitochondrial thiol redox potential is that BOLA1 ortholog... |
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TMPY-05058
|
TMX1 Protein, Human, Recombinant (mFc)
thioredoxin-related transmembrane protein 1,PDIA11,...
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Human
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HEK293 Cells
|
|
As a thiol-based tumor suppressor, TMX1 increases mitochondrial ATP production and apoptosis progression. TMX1 is the first example of a topology-specific client protein redox catalyst acting both in the folding and in the degradative pathways. |
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TMPY-02043
|
PARK7/DJ-1 Protein, Human, Recombinant (His)
DJ1,HEL-S-67p,DJ-1,parkinson protein 7
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Human
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E. coli
|
|
Parkinson's disease locus DJ-1 (PARK7) is a differentially expressed transcript. DJ-1 plays a physiologic role in protection of erythroid cells from oxidant damage, a function unmasked in the context of oxidative stress. PARK7 belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress... |
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TMPH-03073
|
TDX Protein, Japonica rice, Recombinant (His & Myc)
OsTrx26,Tetratricoredoxin,TPR repeat-containing thi...
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Rice
|
E. coli
|
|
Probable thiol-disulfide oxidoreductase that may participate in various redox reactions and act as chaperone under heat shock. May interact with HSP70 proteins through the TPR repeats. TDX Protein, Japonica rice, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 42.0 kDa and the accession number is Q6ES52. |
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TMPY-02433
|
APE1/APEX1 Protein, Human, Recombinant (His)
APEX,HAP1,APX,APE,APEX nuclease (multifunctional DNA repair ...
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Human
|
E. coli
|
|
The enzyme is known to be a redox factor (Ref-1) stimulating DNA binding activity of AP-1 binding proteins such as Fos and Jun as well as a multifunctional DNA repair enzyme having 5' AP endonuclease, DNA 3' repair diesterase, 3'-5' exonuclease and DNA 3'-phosphatase activities.Although Apex mRNA was expressed ubiquitously, the levels varied significantly, suggesting organ- or tissue-specific expression of the Apex gene. The highest level was observed in the testis, relatively high levels in the... |
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TMPJ-01225
|
PDILT Protein, Human, Recombinant (His)
PDILT,Protein Disulfide-Isomerase-Like Protein of the Testis
|
Human
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HEK293 Cells
|
|
Protein Disulfide-Isomerase-Like Protein of the Testis (PDILT) is a protein that belongs to the protein disulfide isomerase family. Human PDILT is synthesized as a 584 amino acid precursor that contains an 20 amino acid signal sequence and a 564 amino acid mature chain. PDILT contains 1 thioredoxin domain lacks the conserved redox-active Cys at position 417 which is replaced by a Ser residue, suggesting that it lacks thioredoxin activity. PDILT is an enzyme in the endoplasmic reticulum in eukary... |
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TMPJ-00720
|
TXNDC12 Protein, Human, Recombinant (His)
TLP19,ERp19,Thioredoxin Domain-Containing Protein 1...
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Human
|
HEK293 Cells
|
|
Thioredoxin Domain-Containing Protein 12 belongs to the thioredoxin superfamily. In this family, proteins possess a thioredoxin fold with a consensus active-site sequence (CxxC) and have roles in redox regulation, defense against oxidative stress, refolding of disulfide-containing proteins, and regulation of transcription factors. TXNDC12 is widely expressed in many tissues and contains one thioredoxin domain. |
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TMPH-02195
|
TXNDC17 Protein, Human, Recombinant (GST)
Thioredoxin-like protein 5,Protein 42-9-9,Thior...
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Human
|
E. coli
|
|
Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide. |
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TMPJ-00934
|
PRDX3 Protein, Human, Recombinant
Protein MER5 homolog,Thioredoxin-Dependent Peroxide...
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Human
|
E. coli
|
|
Thioredoxin-Dependent Peroxide Reductase Mitochondrial (PRDX3) is an enzyme that belongs to the AhpC/TSA family. Human and mouse PRDX3 genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Human PRDX3 protein has an antioxidant function and is localized in the mitochondrion. PRDX3 is involved in redox regulation of the cell. PRDX3 protects radical-sensitive enzymes from oxidative damage by a radical-generating system. It acts synergistically with M... |
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TMPY-02271
|
TRXR1/TXNRD1 Protein, Human, Recombinant (aa 161-647, His)
thioredoxin reductase 1,TR1,TXNR,TR,TRXR1,GRIM-12
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Human
|
E. coli
|
|
Thioredoxin reductase 1 (TXNRD1) which is a selenocysteine-containing protein is overexpressed in many malignancies. TXNRD1 plays a key role in regulating cell growth and transformation, and protects cells against oxidative damage. We investigated the association between TXNRD1 polymorphisms and ATDH susceptibility. Moreover, TXNRD1 is an essential selenium-containing enzyme involved in detoxification of reactive oxygen species (ROS) and redox signaling. And genetic variations in TXNRD1 favor th... |
|
TMPH-03443
|
GPX2 Protein, S. cerevisiae, Recombinant (His & Myc)
Glutathione peroxidase homolog 2,Glutathione peroxidase-like...
|
Saccharomyces cerevisiae
|
E. coli
|
|
Glutathione peroxidase-like protein that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress. Plays an important role in the oxidative stress-induced response in the presence of Ca(2+). Has peroxidase activity using preferentially thioredoxin as a reducing power. The redox state of the mitochondrial GPX2 is regulated by TRX1 and TRX2 (cytoplasmic thioredoxin), and by TRX3 (mitochondrial matrix thioredoxin). Involved in sporulation. GPX2 Protein, ... |
|
TMPJ-00826
|
TXN Protein, Human, Recombinant (His)
ADF,TXN,TRX1,Thioredoxin,TRX,ATL-Derived Factor,TRD...
|
Human
|
E. coli
|
|
Thioredoxin (TXN) is a member of the Thioredoxin family. Thioredoxin exists as a disulfide-linked homodimer and contains one Thioredoxin domain. Thioredoxin is up-regulated by ionizing radiation. Thioredoxin participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Thioredoxin also plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contri... |
|
TMPJ-00666
|
CLIC2 Protein, Human, Recombinant (His)
CLIC2,XAP121,Chloride Intracellular Channel Protein 2
|
Human
|
E. coli
|
|
Chloride Intracellular Channel Protein 2 (CLIC2) is a critical component of all living cells; it regulatescellular traffic of Chloride ion and it can be inserted into membranes anf form chloride ion channels. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions, channel activity depends on the pH. CLIC2 is involved in regulating membrane potential and organic solute transport. CLIC2 modulates the activity of RYR2 and inhibits Calcium influx. CLIC2 can be d... |
|
TMPJ-01098
|
PRDX4 Protein, Human, Recombinant (His)
Prx-IV,Thioredoxin-Dependent Peroxide Reductase A03...
|
Human
|
E. coli
|
|
Peroxiredoxin-4 (PRDX4) is a member of the AhpC/TSA family. PRDX4 is a cytoplasmic protein and contains one thioredoxin domain. PRDX4 exists in homodimer or heterodimer with PRDX1. PRDX4 reduces hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. In addition, PRDX4 is probably involved in redox regulation of the cell, regulating the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-... |
|
TMPY-04771
|
CARKL Protein, Human, Recombinant (His & GST)
SHK,CARKL,sedoheptulokinase
|
Human
|
Baculovirus Insect Cells
|
|
CARKL, also known as SHPK, is a nonprotein kinase of glucose metabolism. CARKL has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. CARKL catalyzes an orphan reaction in the pentose phosphate pathway, refocusing cellular metabolism to a high-redox state upon physiological or artificial downregulation. CARKL-dependent metabolic reprogramming is required for proper M1- and ... |
|
TMPJ-00704
|
SCO1 Protein, Human, Recombinant (GST)
Protein SCO1 Homolog Mitochondrial,SCOD1,SCO1
|
Human
|
E. coli
|
|
Protein SCO1 Homolog, Mitochondrial (SCO1) is a member of the SCO1/2 family. SCO1 has a homodimer structure. SCO1 is located in mitochondrion and is highly expressed in muscle, heart, and brain. It is characterized by high rates of Oxidative Phosphorylation (OxPhos). SCO1 is thought to play a important role in cellular copper homeostasis, mitochondrial redox signaling and insertion of copper into the active site of COX. The defects of SCO1 can result in Mitochondrial Complex IV Deficiency (MT-C4... |
|
TMPJ-01404
|
TMX2 Protein, Human, Recombinant (His)
Cell proliferation-inducing gene 26 protein,TMX2,Thiored...
|
Human
|
E. coli
|
|
TMX2 is a single-pass type I membrane protein and contains 1 thioredoxin domain. Thioredoxin plays an important role in various cellular processes through redox regulation. The Molecular Cloning and characterization of one member of the thioredoxin superfamily, designated as TMX2.The TMX2 cDNA consists of 1644 nucleotides and contains an open reading frame encoding a protein of 372 amino acids with a predicted molecular mass of 42.5 kDa and an isoelectric point of 8.94. The TMX2 protein may pos... |
|
TMPY-03406
|
NMNAT1 Protein, Human, Recombinant (His)
PNAT1,LCA9,nicotinamide nucleotide adenylyltransferase 1,NMN...
|
Human
|
Baculovirus Insect Cells
|
|
NMNAT, also known as NMNAT1, is a member of the Nicotinamide-nucleotide adenylyltransferases. It is widely expressed with high levels in skeletal muscle, heart, liver, and kidney. NMNAT appears to have the ability to protect against axonal degeneration following mechanical or toxic insults. The coenzyme NAD and its derivatives are involved in hundreds of metabolic redox reactions and are utilized in protein ADP-ribosylation, histone deacetylation, and in some Ca(2+) signaling pathways. NMNAT enz... |
|
TMPJ-01020
|
GFER Protein, Human, Recombinant (His)
Augmenter of liver regeneration,FAD-linked sulfhydryl oxidas...
|
Human
|
E. coli
|
|
GFER is a hepatotrophic growth factor and flavin-linked sulfhydryl oxidase which belongs to the Erv1/ALR family of proteins. GFER is widely expressed in various human tissues. They are two isoforms of this protein. Isoform 1 could regenerate the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ER... |
|
TMPY-02890
|
ERP27 Protein, Human, Recombinant (mFc)
endoplasmic reticulum protein 27,C12orf46,PDIA8
|
Human
|
HEK293 Cells
|
|
ERP27 contains 1 thioredoxin domain and is a noncatalytic member of the protein disulfide isomerase family. Protein disulfide isomerases (PDIs) constitute a family of structurally related enzymes which catalyze disulfide bonds formation, reduction, or isomerization of newly synthesized proteins in the lumen of the endoplasmic reticulum (ER). They act also as chaperones, and are, therefore, part of a quality-control system for the correct folding of the proteins in the same subcellular compartmen... |
|
TMPY-01589
|
Serpin B10 Protein, Mouse, Recombinant (His)
Serpinb10-ps,serpin peptidase inhibitor, clade B (ovalbumin)...
|
Mouse
|
Baculovirus Insect Cells
|
|
Serpins are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhi... |
|
TMPY-02299
|
ALDH3A1 Protein, Human, Recombinant (His)
ALDHIII,aldehyde dehydrogenase 3 family, member A1,ALDH3
|
Human
|
Baculovirus Insect Cells
|
|
Aldehyde dehydrogenase 3A1 (ALDH3A1) is a metabolic enzyme that catalyzes the oxidation of various aldehydes. Certain types of epithelial tissues in mammals, especially those continually exposed to environmental stress (e.g., corneal epithelium), express ALDH3A1 at high levels and its abundance in such tissues is perceived to help to maintain cellular homeostasis under conditions of oxidative stress. Metabolic as well as non-metabolic roles for ALDH3A1 have been associated with its mediated resi... |
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