TBHQ

TBHQ (tert-Butylhydroquinone) 是一种抗氧化剂，可通过对氧化还原敏感的转录因子 Nrf2 诱导抗氧化反应。它也是一种ERK 激活剂，逆转 Dehydrocorydaline 对黑素瘤细胞增殖的抑制作用。

产品编号 T5364Cas号 1948-33-0

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TBHQ

产品编号 T5364别名 tert-Butylhydroquinone, 叔丁基氢醌, 特丁基对苯二酚Cas号 1948-33-0

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规格	价格	库存
100 mg	¥ 153	现货
500 mg	¥ 331	现货
1 g	¥ 415	现货
1 mL x 10 mM (in DMSO)	¥ 365	现货

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"TBHQ"的相关化合物库

产品介绍

生物活性

产品描述	TBHQ (tert-Butylhydroquinone) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2.
体外活性	HeLa细胞经t2,5-Di-tert-butylhydroquinone处理后，表现出对线粒体硫氧还蛋白-2(Trx2)的优先氧化，而细胞内谷胱甘肽和细胞质硫氧还蛋白-1未受影响。t2,5-Di-tert-butylhydroquinone处理促使Trx2过表达抑制了Nrf2的积累和活性[1]。在用t2,5-Di-tert-butylhydroquinone预处理Jurkat T细胞，并随之用抗CD3/抗CD28激活之前，能显著降低白介素-2(IL-2)在转录和蛋白水平上的产生。同样，CD25的表达也在经t2,5-Di-tert-butylhydroquinone预处理后减少，尽管此减少的程度较IL-2为轻[2]。
体内活性	TBHQ处理预防了TAC诱导的左室扩张和心脏功能障碍，并降低了心肌细胞凋亡的发生率。TBHQ诱导的Akt激活伴随着Bad、糖原合成酶激酶-3β（GSK-3β）和哺乳动物雷帕霉素靶蛋白（mTOR）的磷酸化增加。体内阻断Akt通路加速了心脏功能障碍，并消除了TBHQ的保护效果。TBHQ还减少了应激心肌中的反应性醛类产物和蛋白质氧化的产生[3]。
细胞实验	Jurkat T cells were cultured in 96-well plates (1×10^5 cells/well) and treated as described, and cell supernatants were harvested 24h after activation with anti-CD3/anti-CD28. IL-2 was quantified from cell supernatants by the use of a commercially available kit per the manufacturer's protocol. Relative light intensity was quantified at 450nm by Bio-Tek μQuant microplate reader. The IL-2 concentrations of each sample were then calculated using a line ar standard curve on Microsoft Excel [2].
动物实验	TBHQ powder was directly mixed with the animal food powder at a ratio of 1% (w/w) as described previously. The efficacy of this protocol for TBHQ treatment in vivo has also been validated by other groups. TBHQ treatment was continued for 4 weeks after the TAC surgery [3].
别名	tert-Butylhydroquinone, 叔丁基氢醌, 特丁基对苯二酚

化学信息

分子量	166.22
分子式	C₁₀H₁₄O₂
CAS No.	1948-33-0

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 50 mg/mL (300.81 mM)

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.0161 mL	30.0806 mL	60.1612 mL	300.8062 mL
5 mM	1.2032 mL	6.0161 mL	12.0322 mL	60.1612 mL
10 mM	0.6016 mL	3.0081 mL	6.0161 mL	30.0806 mL
20 mM	0.3008 mL	1.5040 mL	3.0081 mL	15.0403 mL
50 mM	0.1203 mL	0.6016 mL	1.2032 mL	6.0161 mL
100 mM	0.0602 mL	0.3008 mL	0.6016 mL	3.0081 mL