首页工具

登录

搜索结果

Search Results for " postsynaptic "

Targets Recommended: GluR

44

抑制剂 & 化合物

4

天然产物

13

重组蛋白

1

同位素标记化合物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T3478	Ro 67-7476	GluR	Neuroscience
	Ro 67-7476 是mGluR1的正变位调节剂，能增强表达 rat mGluR1a 的 HEK293 细胞中谷氨酸诱导的钙释放，EC50为 60.1 nM。它是 P-ERK1/2 激动剂，可以在外源添加谷氨酸的情况下激活 ERK1/2 磷酸化 (EC50=163.3 nM)。
TQ0084	lumateperone Tosylate ITI-007,Lumateperone甲苯磺酸盐	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	lumateperone Tosylate (ITI-007) 是5-HT 2A 受体拮抗剂，Ki 为 0.54 nM，突触前 D2受体的部分激动剂和突触后 D2受体的拮抗剂，Ki 为 32 nM。
T21069	Lumateperone ITI 722,ITI722,ITI-007,卢美哌隆,ITI007	5-HT Receptor	GPCR/G Protein; Neuroscience
	Lumateperone (ITI 722) 是一种 5HT2A 受体拮抗剂和多巴胺受体磷蛋白调节剂 (DPPM)。
T3275	Nefazodone hydrochloride Dutonin,MJ-13754-1,Serzone,BMY-13754-1,BMY-13754,萘法唑酮盐酸盐	5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Nefazodone hydrochloride (Serzone) 是一种强效和选择性的5HT2A 拮抗剂，Ki 为5.8 nM，对 5-HT 和去甲肾上腺素摄取具有中度抑制作用，IC50分别为 290 和 300 nM。它是一种苯哌嗪类抗抑郁药，具有微弱的 α-肾上腺素阻断活性，用于治疗抑郁症、攻击性行为和恐慌症。
T23007	MM 77 dihydrochloride MM 77二盐酸盐	5-HT Receptor	GPCR/G Protein; Neuroscience
	MM 77 dihydrochloride 是一种有效的 5-HT1A 受体突触后拮抗剂，具有抗焦虑样活性。
T0101	Doxazosin mesylate UK 33274 mesylate,甲磺酸多沙唑嗪	Mitophagy; Adrenergic Receptor; Autophagy	Autophagy; GPCR/G Protein; Neuroscience
	Doxazosin mesylate (UK 33274 mesylate) 是一种喹唑啉衍生物。它是一种选择性拮抗突触后α1-肾上腺素能受体。
T8631	pyridostigmine Regonol,Mestinon-SR,UNII-19QM69HH21,PyridostigmineBromine,Pyridostigminum	Others	Others
	Pyridostigmine(Regonol) 是一种乙酰胆碱酯酶抑制剂，可通过增加突触后运动终板的乙酰胆碱来治疗重症肌无力。
T25672	Lesopitron	5-HT Receptor	GPCR/G Protein; Neuroscience
	Lesopitron 是一种具有突触前和突触后5-HT1A 激动剂活性的抗焦虑剂，在大鼠社会交往和狨猴焦虑模型中比5-HT1A 激动剂更有效。Lesopitron 能对抗苯二氮卓类药物戒断引起的啮齿动物的焦虑且急性毒性很低，不会增强酒精或巴比妥类药物的作用。
T8452	Dantrolene	Others	Others
	Dantrolene 是一种肌肉松弛剂，是人红细胞谷胱甘肽还原酶的非竞争性抑制剂，其Ki 和IC50值分别为 111.6 μM 和 52.3 μM。它是兰尼碱受体拮抗剂及Ca2+信号稳定剂。它可用于研究恶性高热、亨廷顿病、肌肉痉挛和其他神经阻滞剂恶性综合征。
T1158	Phenoxybenzamine hydrochloride 苯氧苯札明,NCI-c01661,NSC 37448,盐酸酚苄明,Phenoxybenzamine HCl	CaMK; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Phenoxybenzamine hydrochloride (NCI-c01661) 是一种选择性的 α-adrenoceptor 和 calmodulin 的抑制剂，是常用的抗高血压药。
T13112	Tat-NR2B9c Tat-NR2Bct,NA-1	NO Synthase; iGluR	Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience
	Tat-NR2B9c (NA-1) 是一种突触后密度-95（PSD-95）抑制剂，具有神经保护和抗癫痫作用。Tat-NR2B9c 可抑制PSD-95d2、 PSD-95d1 和 PSD-95，可阻止NMDA诱导的神经元NADPH氧化酶的激活，从而阻断超氧化物的产生，可减少中风后急性期的缺血性损伤。
T4440	Saclofen	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Saclofen 是竞争性GABAB 受体拮抗剂(IC50:7.8 μM)。它可研究 GABAB 受体调节大脑中缓慢抑制性突触后电位的功能。
T38192	Unifiram	Others	Others
	Unifiram 是一种认知增强剂。 Unifiram 诱导大鼠海马 CA1 区场兴奋性突触后电位 (fEPSP) 幅度的持久增加 (EC50= 27 nM) 并增加大鼠大脑皮层中乙酰胆碱 (ACh) 的释放。
T7218	Endomorphin 2 内吗啡肽 2	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Endomorphin 2 是一种高亲和力和选择性的 μ-阿片受体激动剂，对 kappa3 结合位点具有合理的亲和力，Ki 为 20 到 30 nM 之间。
T13112L1	Tat-NR2B9c acetate Tat-NR2B9c acetate (500992-11-0 Free base),NA-1 acetate	Others	Others
	Tat-NR2B9c acetate (NA-1 acetate) 是一种突触后密度 95 (PSD-95) 抑制剂，对 PSD-95d2 (PSD-95 PDZ domain 2) 和 PSD-95d1 的 EC50 值分别为 6.7 nM 和 670 nM。它破坏 PSD-95/NMDAR 相互作用，抑制 NR2A 和 NR2B 与 PSD-95 的结合，IC50 值分别为 0.5 μM 和 8 μM。它还抑制神经元一氧化氮合酶 (nNOS)/PSD-95 相互作用，并具有神经保护功效。
TP1945L1	Pep2m, myristoylated acetate Pep2m, myristoylated acetate(1423381-07-0 free base)	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	Pep2m, myristoylated acetate(1423381-07-0 free base) 是一种细胞可渗透的肉豆蔻酰化形式的 pep2m。 GluA2（AMPA 受体）亚基的 C 末端与 N-乙基马来酰亚胺敏感融合蛋白 (NSF)（一种调节 AMPA 受体功能的蛋白质）之间相互作用的肽抑制剂。降低 CA1 神经元中的突触后电流、培养的海马神经元中 AMPA 介导的电流和 AMPA 受体表面表达。
T71444	GYKI-12743 HCl	Others	Others
	GYKI-12743 HCl is a postsynaptic vascular alpha-adrenoceptor antagonist.
T24462	Mezilamine	Others	Others
	Mezilamine is an antagonist of dopamine. It also blocks presynaptic but stimulating postsynaptic alpha-adrenoceptors.
T13162	Tiodazosin BL-5111	Others	Others
	Tiodazosin is a competitive antagonist of the postsynaptic alpha-adrenergic receptor.
T32029	GYKI-16084 GYKI 16084	Others	Others
	GYKI-16084 is a postsynaptic alpha2 receptor blocker with potential efficacy in the treatment of benign prostatic hyperplasia.
T68767	Mezilamine HCl	Others	Others
	Mezilamine HCl is a dopamine antagonist, blocking presynaptic but stimulating postsynaptic alpha-adrenoceptors.
T0068L	Fluphenazine Decanoate Dihydrochloride	Others	Others
	Fluphenazine Decanoate Dihydrochloride is an antipsychotic agent, it could block postsynaptic dopamine D2 receptors in the limbic, cortical system and basal ganglia.
T69787	EF-7412	Others	Others
	EF-7412 is a ligand that is characterized as an antagonist in vivo in pre- and postsynaptic 5-HT(1A)R sites.
T70478	S 15931	Others	Others
	S 15931 antagonizes postsynaptic 5-HT(1A) receptors and is an agonist for 5-HT(1A) autoreceptors.
T26772	Tacitin Tacitin,Benzoctamine HCl,Methyl(methyl-9,10-ethano-9(10H)-anthryl)ammonium chloride,Tacitine,Benzoctamine Hydrochloride,Benzoctamine (hydrochloride)	Others	Others
	Tacitin (Benzoctamine Hydrochloride) 显示出镇静和抗焦虑的特性。Tacitin 能阻断中枢突触后5-羟色胺受体。
T13112L	Tat-NR2B9c TFA NA-1 (TFA)	Others	Others
	Tat-NR2B9c TFA is a 20-aa peptide, and acts as an inhibitor of postsynaptic density-95 (PSD-95)(EC50 of 6.7 nM for PSD-95d2), and possesses neuroprotective efficacy.
T0068L2	Fluphenazine free base Siqualine,Fluphenazine,Fluorophenazine,Fluorphenazine,Triflumethazine,Fluorfenazine	Others	Others
	Flufenazine is an antipsychotic drug. It is used to treat chronic mental illnesses such as schizophrenia. Flufenazine works by blocking postsynaptic dopamine D2 receptors in the limbic system, cortical system, and basal ganglia. This prevents the effects
T28987	TN-871 HCl TN-871 dihydrochloride,TN871,TN 871,TN-871	Others	Others
	TN-871 is a potassium and calcium channel antagonist. TN-871 modulates transmitter release from preganglionic nerve terminals without changing the postsynaptic sensitivity of the ganglion cells to ACh.
T38975	WAY-100135 dihydrochloride	Others	Others
	WAY-100135 dihydrochloride is a potent and selective antagonist of both presynaptic and postsynaptic 5-HT 1A receptors, exhibiting an IC 50 value of 34 nM specifically at the rat hippocampal 5-HT 1A receptor. This compound displays promising antipsychotic effects.
TP2073	BigLEN(mouse) BigLEN (mouse)
	GPR171 agonist. ProSAAS-derived neuropeptide. Regulates food intake in mice. Inhibits the release of glutamate onto parvocellular neurons of the paraventricular nucleus in a process dependent upon activation of postsynaptic G proteins.
T68825	Doxazosin HCl	Others	Others
	Doxazosin HCl is the salt form of Doxazosin Free Base which acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation.
T70340	JHU-58	Others	Others
	JHU-58 is a novel dipeptide MrgC agonist. JHU-58 inhibited both mechanical and heat hypersensitivity in rats after an L5 spinal nerve ligation (SNL). JHU58 attenuated the evoked excitatory postsynaptic currents in substantia gelatinosa (SG) neurons in wild-type mice, but not in Mrg knockout mice, after peripheral nerve injury.
T73685	(R)-Preclamol hydrochloride	Others	Others
	'(R)-Preclamol hydrochloride ((+)-3-PPP hydrochloride)为Preclamol hydrochloride的R-对映异构体，作为DA激动剂，展现出对自身受体及突触后受体的刺激特性。'
T60270	(R)-Preclamol	Others	Others
	(R)-Preclamol 是一种具有自身受体和突触后受体刺激特性的多巴胺 (DA) 激动剂。(R)-Preclamol 以低剂量抑制小鼠和大鼠的运动活动。
T76590	(d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin
	(d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin，是一种催产素受体拮抗剂，可消除 CA1 锥体神经元中催产素增强的抑制性突触后电流。
T82885	BigLEN(mouse) TFA
	BigLEN(mouse) TFA 是一种GPR171激动剂，同时也是源自proSAAS的神经肽。该化合物调节小鼠的食物摄入，并且依赖于突触后G蛋白的激活，抑制谷氨酸释放到下丘脑室旁核的旁核细胞上。
T80704	α-Pompilidotoxin α-PMTX
	α-Pompilidotoxin (α-PMTX) 是从 Anoplius samariensis 的毒液中分离的一种神经毒素。它能剂量依赖性地增强兴奋性突触后电流（EPSCs），并且这种增强作用是可逆的。α-Pompilidotoxin 在神经科学研究中被作为实验工具广泛应用。
T38389	Prostaglandin D2 Ethanolamide Prostaglandin D2 Ethanolamide	Others	Others
	Prostaglandin D2 ethanolamide (PGD2-EA) is a bioactive lipid produced by the sequential metabolism of anandamide (arachidonoyl ethanolamide) by cyclooxygenase (COX) enzymes, in particular by COX-2, and PGD synthase. The biosynthesis of PGD2-EA from anandamide can also be increased when anandamide metabolism is diminished by deletion of fatty acid amide hydrolase. PGD2-EA is inactive against recombinant prostanoid receptors, including the D prostanoid receptor. It increases the frequency of minia...
T70183	Eptapirone fumarate	Others	Others
	Eptapirone, also known as F11440, is a potent 5HT(1A) receptor agonist with marked anxiolytic and antidepressant potential. The affinity of F 11440 for 5-HT1A binding sites (pKi, 8.33) was higher than that of buspirone (pKi, 7.50), and somewhat lower than that of flesinoxan (pKi, 8.91). In vivo, F 11440 was 4- to 20-fold more potent than flesinoxan, and 30- to 60-fold more potent than buspirone, in exerting 5-HT1A agonist activity at pre- and postsynaptic receptors in rats (measured by, for exam...
TP1945	Pep2m, myristoylated
	Cell-permeable, myristoylated form of pep2m. Peptide inhibitor of the interaction between the C-terminus of the GluA2 (AMPA receptor) subunit and N-ethylmaleimide-sensitive fusion protein (NSF), a protein that regulates AMPA receptor function. Reduces pos
T75838	PDZ1 Domain inhibitor peptide TFA
	PDZ1 Domain inhibitor peptide TFA，一种环状肽，以 β-Ala 内酰胺侧链为接头，专一性靶向 PSD-95 的 PDZ1 域。此化合物能干扰 GluR6/PSD-95 间的相互作用，通过与 GluR6 的 C 末端竞争，抑制其在 PDZ1 域的结合。
T70063	GYKI 52466 HCl	Others	Others
	GYKI 52466 is an allosteric AMPA receptor antagonist. It selectively inhibits AMPA-induced inward currents (IC50 = 7.5 µM) over NMDA- or GABA-induced inward currents in primary rat hippocampal neurons at 50 µM but also inhibits kainate-induced inward currents in the same cells (IC50 = 11 µM).2 GYKI 52466 (10 µM) reduces the amplitude of spontaneous excitatory postsynaptic currents (EPSCs) in the same cells. It increases the latency to seizure onset and reduces mortality in a rat model of general...
T79718	CaMKIIα-PHOTAC	CaMK	Neuroscience
	CaMKIIα-PHOTAC是一种靶向Ca2+/钙调蛋白依赖性蛋白激酶IIα（CaMKIIα）的光化学靶向嵌合体（PHOTAC）。该分子在特定波长光照射下实现靶蛋白的泛素化及通过蛋白酶体催化的降解。CaMKIIα-PHOTAC能在光照条件下显著降低小鼠海马区域的诱发LTP反应强度，减弱突触功能，并对维护亚细胞级别的树突结构域、长时程增强及记忆能力起到关键作用。
T38204	GAT229	Others	Others
	GAT229 is a positive allosteric modulator of cannabinoid receptor 1 (CB1) and the S-(-) enantiomer of the CB1 modulator GAT211. It does not activate the receptor on its own but enhances the binding and activity of CB agonists. GAT229 (1 μM) enhances the binding of the CB1 full agonist CP 55,940 to CHO cells expressing human recombinant CB1 (hCB1), as well as the activity of 2-arachidonoyl glycerol , arachidonoyl ethanolamide , and CP 55,940 in arrestin2 recruitment assays and increases ERK1/2 an...

化合物

Cat.No: T3478

Target: GluR

lumateperone Tosylate

Cat.No: TQ0084

Synonym: ITI-007,Lumateperone甲苯磺酸盐

Target: Dopamine Receptor, 5-HT Receptor

Cat.No: T21069

Synonym: ITI 722,ITI722,ITI-007,卢美哌隆,ITI007

Target: 5-HT Receptor

Nefazodone hydrochloride

Cat.No: T3275

Synonym: Dutonin,MJ-13754-1,Serzone,BMY-13754-1,BMY-13754,萘法唑酮盐酸盐

Target: 5-HT Receptor, Adrenergic Receptor

MM 77 dihydrochloride

Cat.No: T23007

Synonym: MM 77二盐酸盐

Target: 5-HT Receptor

Doxazosin mesylate

Cat.No: T0101

Synonym: UK 33274 mesylate,甲磺酸多沙唑嗪

Target: Mitophagy, Adrenergic Receptor, Autophagy

Cat.No: T8631

Synonym: Regonol,Mestinon-SR,UNII-19QM69HH21,PyridostigmineBromine,Pyridostigminum

Target: Others

Cat.No: T25672

Target: 5-HT Receptor

Cat.No: T8452

Target: Others

Phenoxybenzamine hydrochloride

Cat.No: T1158

Synonym: 苯氧苯札明,NCI-c01661,NSC 37448,盐酸酚苄明,Phenoxybenzamine HCl

Target: CaMK, Adrenergic Receptor

Cat.No: T13112

Synonym: Tat-NR2Bct,NA-1

Target: NO Synthase, iGluR

Cat.No: T4440

Target: GABA Receptor

Cat.No: T38192

Target: Others

Cat.No: T7218

Synonym: 内吗啡肽 2

Target: Opioid Receptor

Tat-NR2B9c acetate

Cat.No: T13112L1

Synonym: Tat-NR2B9c acetate (500992-11-0 Free base),NA-1 acetate

Target: Others

Pep2m, myristoylated acetate

Cat.No: TP1945L1

Synonym: Pep2m, myristoylated acetate(1423381-07-0 free base)

Target: PKC

Cat.No: T71444

Target: Others

Cat.No: T24462

Target: Others

Cat.No: T13162

Synonym: BL-5111

Target: Others

Cat.No: T32029

Synonym: GYKI 16084

Target: Others

Cat.No: T68767

Target: Others

Fluphenazine Decanoate Dihydrochloride

Cat.No: T0068L

Target: Others

Cat.No: T69787

Target: Others

Cat.No: T70478

Target: Others

Cat.No: T26772

Synonym: Tacitin,Benzoctamine HCl,Methyl(methyl-9,10-ethano-9(10H)-anthryl)ammonium chloride,Tacitine,Benzoctamine Hydrochloride,Benzoctamine (hydrochloride)

Target: Others

Cat.No: T13112L

Synonym: NA-1 (TFA)

Target: Others

Fluphenazine free base

Cat.No: T0068L2

Synonym: Siqualine,Fluphenazine,Fluorophenazine,Fluorphenazine,Triflumethazine,Fluorfenazine

Target: Others

Cat.No: T28987

Synonym: TN-871 dihydrochloride,TN871,TN 871,TN-871

Target: Others

WAY-100135 dihydrochloride

Cat.No: T38975

Target: Others

Cat.No: TP2073

Synonym: BigLEN (mouse)

Cat.No: T68825

Target: Others

Cat.No: T70340

Target: Others

(R)-Preclamol hydrochloride

Cat.No: T73685

Target: Others

Cat.No: T60270

Target: Others

(d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin

Cat.No: T76590

BigLEN(mouse) TFA

Cat.No: T82885

α-Pompilidotoxin

Cat.No: T80704

Synonym: α-PMTX

Prostaglandin D2 Ethanolamide

Cat.No: T38389

Synonym: Prostaglandin D2 Ethanolamide

Target: Others

Eptapirone fumarate

Cat.No: T70183

Target: Others

Pep2m, myristoylated

Cat.No: TP1945

PDZ1 Domain inhibitor peptide TFA

Cat.No: T75838

Cat.No: T70063

Target: Others

CaMKIIα-PHOTAC

Cat.No: T79718

Target: CaMK

Cat.No: T38204

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T5766	(+)-Coclaurine Coclaurine,乌药碱	Others	Others
	(+)-Coclaurine 是从多种植物来源中分离出来的四氢异喹啉生物碱，具有抗衰老作用。
T3377	L-Phenylalanine L-苯丙氨酸,(S)-2-Amino-3-phenylpropionic acid,phenylalanine,3-Phenyl-L-alanine	Calcium Channel; Endogenous Metabolite; iGluR	Membrane transporter/Ion channel; Metabolism; Neuroscience
	L-Phenylalanine (3-Phenyl-L-alanine) 是分离自大肠杆菌的必需氨基酸，是 NMDARs(KB573 μM) 和非 NMDARs 的甘氨酸和谷氨酸结合位点的竞争性拮抗剂，用于食品香料和药品的生产中。它是一种电压依赖性 α2δ 亚基 Ca2+通道拮抗剂，Ki 为 980 nM。
T4S0145	Corylifol A Corylinin,补骨脂异黄酮A	hCE; STAT; UGT	JAK/STAT signaling; Metabolism; Stem Cells
	Corylifol A (Corylinin) 是补骨脂中的一种天然产物，可抑制IL-6 诱导的STAT3激活和磷酸化，IC50值为0.81 μM。
TN3368	Akuammigine	Opioid Receptor; Adrenergic Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Akuammigine has in vitro antimalarial activity. Akuammigine competitively antagonizes the effect of noradrenaline on postsynaptic alpha-adrenoceptors, yielding pA2 values of 4.68. Akuammidine also shows a preference for mu-opioid binding sites with Ki val

天然产物

Cat.No: T5766

Synonym: Coclaurine,乌药碱

Target: Others

L-Phenylalanine

Cat.No: T3377

Synonym: L-苯丙氨酸,(S)-2-Amino-3-phenylpropionic acid,phenylalanine,3-Phenyl-L-alanine

Target: Calcium Channel, Endogenous Metabolite, iGluR

Cat.No: T4S0145

Synonym: Corylinin,补骨脂异黄酮A

Target: hCE, STAT, UGT

Cat.No: TN3368

Target: Opioid Receptor, Adrenergic Receptor

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00652	PSD-95 Protein, Rat, Recombinant (His) PSD95,SAP90,Disks large homolog 4,SAP-90,PSD-95,Postsyna...	Rat	E. coli
	Disks large homolog 4(DLG4) is a cell membrane protein and it is a member of the membrane-associated guanylate kinase (MAGUK) family. The protein contains 1 guanylate kinase-like domain，3 PDZ (DHR) domains and 1 SH3 domain. With PSD-93 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. DLG4 is the be...
TMPK-00798	IGSF11 Protein, Mouse, Recombinant (His) Bt-IGSF,BtIGSF,IgSF11,VSIG3,Bt IGSF,CXADRL1,CT119	Mouse	HEK293 Cells
	Immunoglobulin superfamily member 11 (IgSF11), a homophilic adhesion molecule that preferentially expressed in the brain, is a dual-binding partner of the postsynaptic scaffolding protein PSD-95 and AMPA glutamate receptors (AMPARs).
TMPH-02331	GLRA1 Protein, Human, Recombinant (His & Myc) Glycine receptor subunit alpha-1,GLRA1,Glycine receptor stry...	Human	E. coli
	Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Channel activity is potentiat...
TMPH-00423	Tetanus toxin Protein, Clostridium tetani, Recombinant (B2M & His) Tentoxylysin,Tetanus toxin,tetX	Clostridium tetani	E. coli
	Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-\|-Phe-77' bond of synaptobrevin-2. Tetanus toxin Protein, Clostridium tetani, Recombinant (B2M & His) is expressed in E. coli expression...
TMPJ-01401	NTNG1 Protein, Human, Recombinant (hFc) NTNG1,LMNT1,Netrin-G1,Laminet-1	Human	HEK293 Cells
	Netrin-G1, known as NTNG-1, and is a member of the UNC-6/Netrin family of proteins. The NTNG1 gene is located on chromosome 1p13.3 and encodes a glycosylphosphatidylinositol protein anchored to the presynaptic membrane. Netrin G1 molecule has been described to be involved in axonal guidance/maintenance and axonal growth cone by specifically interacting with its receptor the Netrin G1 ligand (NGL-1), which is located at the postsynaptic compartment. Netrin Gs knockout mice have disturbed subdendr...
TMPJ-00944	PPP1CC Protein, Human, Recombinant (His) PP-1G,Serine/Threonine-Protein Phosphatase PP1-Gamma Catalyt...	Human	E. coli
	Serine/Threonine-Protein Phosphatase PP1-Υ Catalytic Subunit (PPP1CC) is a member of the PPP phosphatase family. It is essential for cell division, participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. PPP1CC colocalizes with SPZ1 in the nucleus, with URI1 at mitochondrion, Rapidly exchanges between the nucleolar, nucleoplasmic and cytoplasmic compartments. As a cofactor, PPP1CC binds one iron ion and one manganese ion per subunit.. In addition, PPP1C...
TMPY-04414	MUSK Protein, Human, Recombinant (aa 433-783, His & GST) FADS,CMS9,muscle, skeletal, receptor tyrosine kinase	Human	Baculovirus Insect Cells
	Muscle, skeletal receptor tyrosine-protein kinase, also known as Muscle-specific tyrosine-protein kinase receptor, Muscle-specific kinase receptor, and MUSK, is a single-pass type I membrane protein that belongs to the protein kinase superfamily and tyr protein kinase family. MUSK contains one FZ (frizzled) domain, three Ig-like C2-type (immunoglobulin-like) domains, and one protein kinase domain. This protein is a muscle-specific tyrosine kinase receptor and it may play a role in clustering of ...
TMPH-00430	VxXIIC Protein, Conus vexillum, Recombinant (His & Myc & SUMO) Alpha-conotoxin VxXXC,VxXIIC	Conus vexillum	E. coli
	Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin specifically blocks mammalian neuronal nAChR of the alpha-7/CHRNA7, alpha-3-beta-2/CHRNA3-CHRNB2 and alpha-4-beta-2/CHRNA4-CHRNB2 subtypes. VxXXA and VxXXB inhibit alpha-7/CHRNA7 and alpha-3-beta-2/CHRNA3-CHRNB2 nAChR more efficiently than VxXXC. VxXXB is the most effective at inhibiting alpha-4-beta-2/CHRNA4-CHRNB2 nAChR, followed by VxXXC and VxXXA. VxXII...
TMPY-04373	CAMKII alpha/CAMK2A Protein, Human, Recombinant (GST) calcium/calmodulin-dependent protein kinase II alpha,calcium...	Human	Baculovirus Insect Cells
	Ca2+/calmodulin-dependent protein kinase2A (CAMK2A) belongs to the serine/threonine protein kinase family and, together with other 28 different isoforms, belongs to the Ca2+/ calmodulin-dependent protein kinase subfamily. CaM kinase Ⅱ is thought to be an important mediator of learning and memory and is also necessary for Ca2+homeostasis and reuptake in cardiomyocytes chloride transport in epithelia, positive T-cell selection, and CD8 T-cell activation. CAMKIIA is one of the major forms of CAMKII...
TMPY-01842	Neuroligin-3/NLGN3 Protein, Human, Recombinant (His) neuroligin 3,HNL3	Human	HEK293 Cells
	Neuroligin 3 (NLGN3) is a member of the type-B carboxylesterase/lipase family. Neuroligins (NLGNs) are a family of presumptive postsynaptic cell adhesion molecules. Neuroligins (NLs) constitute a family of cell-surface proteins that interact with neurexins (beta-Nxs), another class of neuronal cell-surface proteins, one of each class functioning together in synapse formation. Neuroligins control the formation and functional balance of excitatory and inhibitory synapses in hippocampal neurons. NL...
TMPY-03750	CRIPT Protein, Human, Recombinant (His) HSPC139,SSMDF,cysteine-rich PDZ-binding protein	Human	E. coli
	CRIPT, also known as cysteine-rich PDZ-binding protein, belongs to the CRIPT family. It interacts with TUBB1. CRIPT also interacts strongly with the PDZ3 domain of members of the DLG4 family. It is involved in the cytoskeletal anchoring of DLG4 in excitatory synapses. CRIPT is highly conserved from mammals to plants and binds selectively to the third PDZ domain (PDZ3) of PSD-95 via its C terminus. n heterologous cells, CRIPT causes a redistribution of PSD-95 to microtubules. In brain, CRIPT colo...
TMPY-01692	NETO1 Protein, Human, Recombinant (His) neuropilin (NRP) and tolloid (TLL)-like 1,BCTL1,BTCL1	Human	HEK293 Cells
	Neuropilin tolloid-like 1 (NETO1), a complement C1r/C1s, Uegf, Bmp1 (CUB) domain-containing transmembrane protein, is a novel component of the NMDAR complex critical for maintaining the abundance of NR2A-containing NMDARs in the postsynaptic density. The N-methyl-D-aspartate receptor (NMDAR), a major excitatory ligand-gated ion channel in the central nervous system (CNS), is a principal mediator of synaptic plasticity. Both NETO1 and NETO2 share an identical and unique domain structure thus repr...
TMPJ-01188	CORO6 Protein, Human, Recombinant (His) Coronin-6,Clipin-E,CORO6	Human	E. coli
	Coronin 6, a newly identified member of the coronin family, is highly enriched at adult NMJs and regulates AChR clustering via modulating the interaction between receptors and the actin cytoskeletal network. Coronins are a family of conserved actin-binding proteins originally identified in the actin-rich structure of the amoeba Dictyostelium discoideum . To date, seven members of coronins have been identified in mammals, and most exhibit tissue-specific distribution patterns. Coronin 6 is promin...

重组蛋白

PSD-95 Protein, Rat, Recombinant (His)

Cat.No: TMPJ-00652

Species: Rat

Expression System: E. coli

IGSF11 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00798

Species: Mouse

Expression System: HEK293 Cells

GLRA1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02331

Species: Human

Expression System: E. coli

Tetanus toxin Protein, Clostridium tetani, Recombinant (B2M & His)

Cat.No: TMPH-00423

Species: Clostridium tetani

Expression System: E. coli

NTNG1 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-01401

Species: Human

Expression System: HEK293 Cells

PPP1CC Protein, Human, Recombinant (His)

Cat.No: TMPJ-00944

Species: Human

Expression System: E. coli

MUSK Protein, Human, Recombinant (aa 433-783, His & GST)

Cat.No: TMPY-04414

Species: Human

Expression System: Baculovirus Insect Cells

VxXIIC Protein, Conus vexillum, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-00430

Species: Conus vexillum

Expression System: E. coli

CAMKII alpha/CAMK2A Protein, Human, Recombinant (GST)

Cat.No: TMPY-04373

Species: Human

Expression System: Baculovirus Insect Cells

Neuroligin-3/NLGN3 Protein, Human, Recombinant (His)

Cat.No: TMPY-01842

Species: Human

Expression System: HEK293 Cells

CRIPT Protein, Human, Recombinant (His)

Cat.No: TMPY-03750

Species: Human

Expression System: E. coli

NETO1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01692

Species: Human

Expression System: HEK293 Cells

CORO6 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01188

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T19297	Doxazosin D8 UK 33274 D8	Others	Others
	Doxazosin D8 (UK 33274 D8) is a deuterium labeled Doxazosin (UK 33274).Doxazosin, a quinazoline derivative, selectively antagonizes postsynaptic AP1 adrenergic receptor.

同位素标记化合物

Cat.No: T19297

Synonym: UK 33274 D8

Target: Others

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼