81
28
4
23
8
Cat. No. | Product Name | ||
---|---|---|---|
L2610 | 神经递质受体化合物库 | 1513 compounds | |
1513 种与神经递质受体相关的化合物,用于高通量、高内涵筛选; | |||
L7300 | 钾通道分子库 | 152 compounds | |
152 种钾通道相关化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L2800 | 5-羟色胺分子库 | 268 compounds | |
268 种生物活性小分子化合物,用于高通量、高内涵筛选; | |||
L3300 | 组胺&褪黑色素化合物库 | 153 compounds | |
153 种生物活性小分子化合物,用于高通量、高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6259 |
Dizocilpine
地佐环平,MK-801 |
NMDAR; iGluR | Membrane transporter/Ion channel; Neuroscience |
Dizocilpine (MK-801) 是一种选择性非竞争性NMDA 受体拮抗剂,Kd=37.2 nM,是一种抗惊厥剂。它通过与 NMDA 相关离子通道内的一个位点结合而起作用,从而阻止 Ca2+的流动。 | |||
TP1253 |
Argireline
六胜肽,Acetyl hexapeptide-3,阿基瑞林 |
Others | Others |
Argireline (Acetyl hexapeptide-3) 是可渗透皮肤的、无毒的抗皱肽。它对神经肌肉接头处依赖 Ca2+的神经递质释放具有显著的抑制作用。它具有抗皱和抗衰老的活性。 | |||
T4297 |
Flibanserin
BIMT-17BS,氟立班丝氨,Girosa,BIMT-17 |
Dopamine Receptor; 5-HT Receptor | GPCR/G Protein; Neuroscience |
Flibanserin (Girosa) 一种具有口服活性的 5-HT1A 受体激动剂和 5-HT2A 受体拮抗剂,Ki 值分别为 1 和 49 nM。它与多巴胺 D4 受体结合,Ki 值在 4 到 24 nM 之间。它是一种血清素能抗抑郁药,用于治疗性欲减退症。 | |||
T3320 |
Dizocilpine Maleate
(+)-Mk-801 Hydrogen Maleate,MK 801,地卓亚平马来酸盐,Dizocilpine hydrogen maleate,地佐环平马来酸盐,(+)-MK 801 maleate,(+)-MK 801 (Maleate) |
NMDAR; iGluR | Membrane transporter/Ion channel; Neuroscience |
Dizocilpine Maleate (MK 801) 是一种选择性和非竞争性的 NMDA 受体拮抗剂,Kd 值为 37.2 nM。它用于治疗 NMDA 受体可能发挥重要作用的多种神经退行性疾病或疾病。 | |||
T16800 |
(RS)-AMPA
(±)-AMPA |
iGluR | Membrane transporter/Ion channel; Neuroscience |
(RS)-AMPA ((±)-AMPA) 是谷氨酸的一种类似物,对兴奋性神经递质 L-谷氨酸有激动作用。它不会干扰海藻酸或 NMDA 受体的结合位点。 | |||
T3269 |
Metadoxine
pyridoxine-pyrrolidone carboxylat,Metasin,Metadoxil,美他多辛 |
5-HT Receptor; PKA | GPCR/G Protein; Neuroscience; Tyrosine Kinase/Adaptors |
Metadoxine (Metadoxil) 能够阻断蛋白激酶 A- cAMP 反应原件结合蛋白通路,阻断脂肪细胞的分化。 | |||
T12352 |
Oxidopamine hydrochloride
6-Hydroxydopamine hydrochloride,6-OHDA hydrochloride,6-羟基多巴胺盐酸盐 |
Mitophagy; Dopamine Receptor; Autophagy | Autophagy; GPCR/G Protein; Neuroscience |
Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) 是一种神经递质多巴胺拮抗剂,可选择性地破坏多巴胺能神经元,是一种广泛使用的神经毒素。 | |||
T0426 |
Piracetam
UCB-6215,吡拉西坦 |
GluR; iGluR | Membrane transporter/Ion channel; Neuroscience |
Piracetam (UCB-6215) 是神经递质 γ-氨基丁酸 (GABA) 的环状衍生物,用于治疗广泛的认知障碍。 | |||
T2990 |
Phenibut
Phenybut,Fenigam,非尼布特,Fenibut,PhGABA,Aminophenylbutyric acid,β-Phenyl-γ-aminobutyric acid |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Phenibut (Aminophenylbutyric acid) 是GABA-B 激动剂,可作为 GABA 类似物,主要作用于 GABAB 受体,具有抗焦虑和增强认知的作用。 | |||
T4174 |
NSC 191412
|
Others | Others |
NSC 191412 能与多种酶和受体相互作用,包括乙酰胆碱酯酶和神经递质多巴胺的受体,是这些酶和受体的激动剂或激活剂。 | |||
T12352L |
Oxidopamine hydrobromide
6-Hydroxydopamine hydrobromide,6-羟基多巴胺氢溴酸盐,6-OHDA hydrobromide |
Mitophagy; Dopamine Receptor; Autophagy | Autophagy; GPCR/G Protein; Neuroscience |
Oxidopamine hydrobromide (6-OHDA hydrobromide) 是一种神经递质多巴胺拮抗剂,可选择性地破坏多巴胺能神经元,是一种广泛使用的神经毒素。 | |||
T9857L |
Vasopressin acetate
Vasopressin acetate (11000-17-2 Free base) |
Endogenous Metabolite | Metabolism |
Vasopressin acetate 是一种环状九肽,在下丘脑中枢合成。 Vasopressin acetate 作为一种神经递质,通过与特定的 G 蛋白偶联受体结合发挥其作用。 | |||
T0267 |
Zonisamide
AD 810,唑尼沙胺,CI 912 |
Calcium Channel; Sodium Channel; Carbonic Anhydrase | Membrane transporter/Ion channel; Metabolism |
Zonisamide (AD 810) 是锌酶碳酸酐酶 (carbonic anhydrase) 的有效抑制剂,对人类线粒体同工酶 hCA II 和 hCA V 作用的 Ki 值分别为 35.2 nM 和 20.6 nM。Zonisamide 具有抗癫痫活性,在癫痫、癫痫发作和帕金森病的研究中具有价值。 | |||
T0290 |
Tizanidine hydrochloride
盐酸替扎尼定,Tizanidine HCl,DS 103-282 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Tizanidine hydrochloride (Tizanidine HCl) 是一种 α2-肾上腺素受体激动剂,可抑制神经递质从 CNS 去甲肾上腺素激活的神经元中释放。 | |||
TP2309 |
Neurotensin TFA
NEUROTENSIN TFA,Neurotensin TFA (39379-15-2 free base),神经加压素 |
Others | Others |
Neurotensin TFA (39379-15-2 free base) 是一种内源性 13 个氨基酸的神经肽,具有显着的阿片类非依赖性镇痛作用。它在大脑中充当神经递质,在肠道中充当激素,也充当神经调节剂。由于它与多种神经递质系统如多巴胺能、血清素能、谷氨酸能、GABA 能和胆碱能系统。它具有作为人体代谢物、有丝分裂原、神经递质和创伤的作用。 | |||
TP1981L |
Neuropeptide S (Mouse) acetate
|
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
Neuropeptide S (Mouse) acetate 是一种生物活性肽。它作为 20 种氨基酸的神经递质/神经调节剂,可用于觉醒、焦虑、运动、摄食行为、记忆和药物成瘾的研究。 | |||
T7401 |
(S)-3-AMino-2-Methylpropanoic acid-HCl
|
Others | Others |
(S)-3-AMino-2-Methylpropanoic acid-HCl 是一种氨基酸衍生物,是兴奋性神经递质谷氨酸的激动剂,影响神经系统。 | |||
T11393 |
GET73
Gamma hydroxybutyric acid analogue,GET 73 |
GluR | Neuroscience |
GET73 (Gamma hydroxybutyric acid analogue) 是天然神经递质 γ-羟基丁酸的类似物。它对谷氨酸在海马的传递有显著的影响。它具有抗酒精和抗焦虑的作用。 | |||
T0719 |
Tetrabenazine
Xenazine,丁苯那嗪,Ro 1-9569 |
Others; Dopamine Receptor; Monoamine Transporter | GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience; Others |
Tetrabenazine (Ro 1-9569) 是 VMAT 抑制剂,用作抗精神病药和治疗各种运动障碍。 | |||
T2663 |
GTS-21 dihydrochloride
GTS 21 dihydrochloride,DMXB-A,DMBX-anabaseine |
5-HT Receptor; AChR | GPCR/G Protein; Neuroscience |
GTS-21 dihydrochloride (DMBX-anabaseine) 是一种选择性 α7 烟碱乙酰胆碱受体激动剂,具有抗炎和增强认知的活性。它也是一种拮抗剂,对人α4β2的 Ki 为20 nM,对5-HT3A 受体的 IC50为3.1 μM。 | |||
T4440 |
Saclofen
|
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Saclofen 是竞争性GABAB 受体拮抗剂(IC50:7.8 μM)。它可研究 GABAB 受体调节大脑中缓慢抑制性突触后电位的功能。 | |||
T20344 |
Acetylcholine bromide
|
Others | Others |
Acetylcholine bromide 是乙酰胆碱的溴化物盐。它是一种神经递质,存在于神经肌肉接头、自主神经节、副交感神经效应器接头、交感神经效应器接头的一个子集以及中枢神经系统的许多部位。 | |||
T9146 |
ms48107
Benzenemethanol, 2-[4-amino-6-[[(4-phenoxyphenyl)methyl]amino]-1,3,5-triazin-2-yl]-3-fluoro- |
Others | Others |
MS48107 是 G 蛋白偶联受体 68 (GPR68) 的选择性正变构调节剂,对GPR68的选择性高于密切相关的神经递质转运蛋白,质子 GPCR 和 hERG 离子通道。它可以穿越过小鼠的血脑屏障。 | |||
T1471 |
Duloxetine hydrochloride
Duloxetine HCl,盐酸度洛西汀,LY-248686 hydrochloride,(S)-Duloxetine hydrochloride,LY-248686 HCl |
Dopamine Receptor; 5-HT Receptor; Serotonin Transporter; Norepinephrine | GPCR/G Protein; Neuroscience |
Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) 是一种 5-羟色胺-去甲肾上腺素重吸收 (serotonin-norepinephrine reuptake) 抑制剂 (SNRI),Ki=4.6 nM,可用于广泛性焦虑症的研究。 | |||
T7783 |
2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINE
|
Others | Others |
2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINE 是一种单胺类神经递质,已被研究其调节各种神经递质活性的潜力,包括血清素、多巴胺和去甲肾上腺素,还研究了其作为5-HT2A 受体激动剂的潜力。 | |||
T50046 |
L-Valyl-L-phenylalanine HCl
Valylphenylalanine HCl; H-VAL-PHE-OH HCl |
Others | Others |
2-(2-amino-3-methylbutanamido)-3-phenylpropanoic acid hydrochloride 是一种氨基酸类化合物,是谷氨酸的合成类似物,谷氨酸是中枢神经系统中的一种重要神经递质。它已被研究其在各种神经疾病中的潜在治疗应用,包括阿尔茨海默病、帕金森病和癫痫。 | |||
T50094 |
DL-Willardiine
2-amino-3-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)propanoic acid |
Others | Others |
DL-Willardiine (2-amino-3-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)propanoic acid) 是一种非天然氨基酸,谷氨酸的衍生物。它是mGluR5的激动剂,可以调节参与神经递质合成和分解的酶的活性,并影响离子通道和其他膜蛋白的活性。 | |||
T6604 |
Nepicastat hydrochloride
Nepicastat HCl,内匹司他盐酸盐,RS-25560-197 hydrochloride,SYN-117 hydrochloride,Nepicastat (SYN-117) HCl |
Hydroxylase | Metabolism |
Nepicastat hydrochloride (RS-25560-197 hydrochloride) 是一种选择性的,有效的,口服活性的多巴胺 β 羟化酶(dopamine-beta-hydroxylase)抑制剂,对牛和人多巴胺 β 羟化酶的IC50分别为IC50=8.5 nM 和IC50=9 nM。Nepicastat HCl 可以穿过血脑屏障。 | |||
T3534 |
Tetrabenazine Racemate
Nitoman,丁苯那嗪外消旋体,丁苯那嗪,Ro 1-9569 Racemate,Rubigen,TETRABENAZINE |
Monoamine Transporter | Membrane transporter/Ion channel |
Tetrabenazine Racemate (Rubigen) 是一种选择性和可逆的囊泡单胺转运蛋白 2(VMAT-2) 抑制剂。它阻断神经递质吸收到肾上腺素能储存囊泡中,并已被用作囊泡运输系统的高亲和力标记。 | |||
T16263 |
N6-Cyclopentyladenosine
UK-80882,CPA |
Adenosine Receptor | GPCR/G Protein; Neuroscience |
N6-Cyclopentyladenosine (CPA) 是一个选择性的腺苷A1 受体 (Adenosine A1 receptor)的激动剂,可用于模拟腺苷A1受体的作用,对人A1、A2A 和 A3 受体的Ki 分别为 2.3 nM、790 nM 和 43 nM。N6-Cyclopentyladenosine (CPA) 可用于调节细胞信号传导、神经递质释放和其他生物学过程。 | |||
T9492 |
3-METHOXY-DL-TYROSINE
|
Others | Others |
3-METHOXY-DL-TYROSINE 是一种在人体和许多其他生物体中发现的天然氨基酸,是一种非必需氨基酸。它是神经递质多巴胺的前体,参与大脑中多巴胺水平的调节,在多种疾病中有潜在治疗应用,包括帕金森病、抑郁症和肥胖症。 | |||
T9340 |
1-phenyl-3,4-dihydroisochinoline
3,4-Dihydro-1-phenylisoquinoline,1-苯基-3,4-二氢异喹啉 |
Others | Others |
1-phenyl-3,4-dihydroisochinoline (3,4-Dihydro-1-phenylisoquinoline) 是神经递质多巴胺的结构类似物,与中枢神经系统中的多巴胺受体相互作用。它已被研究为治疗帕金森病、阿尔茨海默病和亨廷顿舞蹈症等神经疾病的潜在治疗剂。 | |||
T50008 |
2,2-Dimethyl-5-(2,5-xylyloxy)valeramide
5-(2,5-二甲基苯氧基)-2,2-二甲基戊酰胺,5-(2,5-dimethylphenoxy)-2,2-dimethylpentanamide |
Others | Others |
2,2-Dimethyl-5-(2,5-xylyloxy)valeramide (5-(2,5-dimethylphenoxy)-2,2-dimethylpentanamide) 是一种苯氧基家族化合物。它已被证明对神经系统具有刺激作用,包括神经元放电率的增加、突触传递的增加和神经递质释放的增加;还被证明对心血管系统有刺激作用,包括提高心率和血压。 | |||
T41194 |
FFN 102 mesylate
|
Others | Others |
FFN 102 mesylate 是pH 响应型荧光假神经递质(FFN),作为选择性多巴胺转运蛋白(DAT)和VMAT2底物。FFN 102 mesylate 与38个中枢神经系统受体(包括多巴胺和血清素受体)无明显结合。它的Ex-max在pH 值5时为340 nm,在pH 值7.5时为370 nm,在pH 值为5和7.5时,Em-max为435 nm。 | |||
T3354 |
BIA 10-2474
BIA10-2474 |
FAAH; Autophagy | Autophagy; Metabolism; Neuroscience |
BIA 10-2474 是一种长效可逆的脂肪酸酰胺水解酶抑制剂,与人类内源性大麻素系统相互作用,可增加中枢神经系统和外周组织,对大鼠大脑不同区域的 IC50值为50至70mg/kg。它用于治疗焦虑症、帕金森氏病和多发性硬化症、高血压或肥胖症的慢性疼痛。 | |||
T9857 |
Vasopressin
antidiuretic hormone (ADH),argipressin,arginine vasopressin (AVP) |
Endogenous Metabolite | Metabolism |
Vasopressin (argipressin) 是一种由下丘脑神经元合成的环状九肽,是肽原激素合成中的一种激素。Vasopressin 参与下丘脑-垂体-肾上腺轴调节过程,增加无溶质水从肾小管的滤液中重新吸收回循环中的量,收缩小动脉提高压强,增强促肾上腺皮质激素释放因子的刺激作用调节垂体促肾上腺皮质激素分泌。Vasopressin 在神经传导过程中可作为神经递质,与特定的 G 蛋白偶联受体结合发挥作用。 | |||
T21409 |
GABOB (beta-hydroxy-GABA)
β-hydroxy-GABA,beta-hydroxy-GABA,GABOB |
Others | Others |
GABOB is an anticonvulsant used to treat epilepsy. GABOB is an endogenous active metabolite, it is analogue to the neurotransmitter γ-aminobutyric acid (GABA), therefore may function as a neurotransmitter. | |||
T21340 |
Pergolide
|
Others | Others |
Pergolide, an ergoline-based dopamine receptor agonist, is used for the treatment of Parkinson's disease, which is associated with low levels of the neurotransmitter dopamine in the brain. | |||
T22781 |
FFN 511
|
Others | Others |
Fluorescent false neurotransmitter (FFN) | |||
T20522 |
Acetylcholine perchlorate
AI351678,AI3-51678,AI3 51678 |
Others | Others |
Acetylcholine perchlorate is the perchlorate salt of acetylcholine. Acetylcholine, an endogenous neurotransmitter at cholinergic synapses, could amplify the action potential of the sarcolemma following by inducing muscle contractions. | |||
T25107 |
Arginylphenylalaninamide
Rfamide,Arg-phe-NH2 |
Others | Others |
Arginylphenylalaninamide, an FMRamide fragment, may be utilized as a neurotransmitter or neuromodulator by optic lobe neurons of different types. | |||
TP2155 |
Substance P TFA
Neurokinin P TFA |
Others | Others |
Substance P TFA (Neurokinin P TFA) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS, targeting the neurokinin 1 receptor (NK1-receptor, NK1R). | |||
T0128L |
Vigabatrin Hydrochloride
盐酸氨己烯酸,γ-Vinyl-GABA hydrochloride |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Vigabatrin Hydrochloride (γ-Vinyl-GABA hydrochloride) 是抑制性神经递质 GABA 乙烯基衍生物,不可逆地抑制 GABA 转氨酶对 GABA 的分解代谢,增加脑中 GABA 的水平。 | |||
TP1253L |
Argireline acetate
|
||
Argireline acetate 显着抑制神经肌肉接头处 Ca2+ 依赖性神经递质(乙酰胆碱)的释放。 Argireline acetate 具有抗皱和抗衰老活性。 | |||
T39962 |
Valiloxibic acid
XWL-008,Acidum valiloxibicum |
Others | Others |
Valiloxibic acid is a prodrug of γ-Hydroxybutyric acid (GHB).GHB is a naturally occurring neurotransmitter and a psychoactive drug, it acts on the GHB receptor and is a weak agonist at the GABAB receptor. | |||
T15743 |
Levomepromazine
Methotrimeprazine |
Others | Others |
Methotrimeprazine is an orally available neuroleptic agent. It is commonly used to relieve nausea and vomiting in palliative care settings. Levomepromazine has antagonist actions at multiple neurotransmitter receptor sites, including cholinergic, dopamine | |||
T26260 |
Tetrabenazine methanesulfonate
NSC169886,NSC 169886,NSC-169886 |
Others | Others |
Tetrabenazine methanesulfonate is a medicine formerly utilized as an antipsychotic and therapy for various movement disorders. Tetrabenazine methanesulfonate blocks neurotransmitter uptake into adrenergic storage vesicles and has been used as a high-affin | |||
T77212 |
L-α-lysophosphatidylinositol (Soy) (sodium)
|
Others | Others |
L-α-lysophosphatidylinositol Soy sodium 作为GPR55的内源性配体,是一种既属于内源性溶血磷脂也是内源性大麻素神经递质的化合物。 | |||
T70010 |
Kaitocephalin
|
Others | Others |
Kaitocephalin is a non-selective ionotropic glutamate receptor antagonist, meaning it blocks the action of the neurotransmitter glutamate. It is produced by the fungus Eupenicillium shearii. Although similar molecules have been produced synthetically, kaitocephalin is the only known naturally occurring glutamate receptor antagonist. | |||
TP2026 |
GRP (porcine)
|
||
Mammalian bombesin-like peptide neurotransmitter that is an agonist for the gastrin-releasing peptide receptor (GRPR). GRP has been reported to activate GABAergic interneurons in the amygdala leading to increased GABA release and fear suppression in mice |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2850 |
Bicuculline
荷包牡丹碱,(+)-Bicuculline,d-Bicuculline |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Bicuculline ((+)-Bicuculline) 是从东北延胡索中提取的一种生物碱,能阻断 Ca2+激活钾 (SK) 通道。它是一种竞争性的神经递质 GABAA 受体拮抗剂,IC50为 2 μM。 | |||
T1644 |
Dopamine hydrochloride
盐酸多巴胺,Dopamine HCl,ASL279 |
Ferroptosis; Dopamine Receptor; 5-HT Receptor; Endogenous Metabolite | Apoptosis; GPCR/G Protein; Metabolism; Neuroscience |
Dopamine hydrochloride (ASL279) 是在脑黑质、脑腹侧被盖区和下丘脑中产生的一种天然儿茶酚胺,由二羟基苯丙氨酸脱羧形成,是去甲肾上腺素和肾上腺素的前体。它通过 D2 多巴胺受体来诱导 VEGFR2 的内吞作用,有促进血管生成活性。 | |||
T0469 |
Octopamine hydrochloride
章鱼胺盐酸盐,(±)-p-Octopamine hydrochlorid,(+,-)-Octopamine HCl,章胺盐酸盐 |
Dopamine Receptor; Endogenous Metabolite; Adrenergic Receptor | GPCR/G Protein; Metabolism; Neuroscience |
Octopamine hydrochloride ((±)-p-Octopamine hydrochlorid) 是一种与去甲肾上腺素结构相关的生物单胺类物质,在无脊椎动物中起着神经调节剂、神经激素和神经递质的作用。它对转染人 alpha2-肾上腺素受体(ARs)的中国仓鼠卵巢细胞 α2-ARs 有刺激作用。它提高糖原分解、糖酵解、糖异生、摄氧量和门脉灌注压。 | |||
T0508 |
γ-Aminobutyric acid
Gamma-aminobutyric acid,4-Aminobutyric acid,4-氨基丁酸,γ-氨基丁酸,GABA,4-Aminobutanoic acid,Piperidic acid |
GABA Receptor; Endogenous Metabolite | Membrane transporter/Ion channel; Metabolism; Neuroscience |
γ-Aminobutyric acid (4-Aminobutyric acid) 是成年哺乳动物大脑中主要的抑制性神经递质,能够与离子移变 GABA 受体(GABAA) 受体和促代谢受体 (GABAB) 受体结合发挥作用。 | |||
T2596 |
N-Acetyl-β-Asp-Glu
|
Others | Others |
N-Acetyl-β-Asp-Glu 是一种肽类神经递质,是哺乳动物神经系统中第三常见的神经递质。 NAAG 由通过肽键偶联的 N-乙酰天冬氨酸 (NAA) 和谷氨酸组成。 | |||
T21066 |
Norepinephrine bitartrate salt
|
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Norepinephrine bitartrate salt 是一种肾上腺素能神经递质。 | |||
T4860 |
5-Hydroxytryptamine creatinine sulfate monohydrate
Serotonin creatinine sulfate monohydrate,5-Hydroxytryptamine creatinine sulfate complex,5-五羟色胺肌酸酐 |
Others; Endogenous Metabolite | Metabolism; Others |
5-Hydroxytryptamine creatinine sulfate monohydrate (Serotonin creatinine sulfate monohydrate) 是内源性代谢产物的一种。 | |||
T5855 |
Edrophonium chloride
|
AChE | Neuroscience |
Edrophonium chloride 是一种乙酰胆碱酯酶抑制剂,可通过特异性结合其催化位点来防止神经递质乙酰胆碱的分解。 | |||
T2209 |
Serotonin hydrochloride
5-HT hydrochloride,5-羟基色胺盐酸盐,5-HT HCl,Serotonin HCl,5-Hydroxytryptamine hydrochloride |
5-HT Receptor; Endogenous Metabolite; Transferase | GPCR/G Protein; Metabolism; Neuroscience |
Serotonin hydrochloride (Serotonin HCl) 是一种内源性 5-HT 受体激动剂、CNS 中的单胺神经递质和儿茶酚 O-甲基转移酶 (COMT) 抑制剂,Ki 值为 44 μM。 | |||
T0627 |
β-Alanine
beta-Alanine,beta-氨基丙酸,3-Aminopropanoic acid,2-Carboxyethylamine,β-丙氨酸 |
GABA Receptor; Endogenous Metabolite | Membrane transporter/Ion channel; Metabolism; Neuroscience |
β-Alanine (3-Aminopropanoic acid) 是一种天然存在的β-氨基酸,在体内由二氢尿嘧啶和肌肽降解形成,它作为神经递质可激活甘氨酸和GABA受体。 | |||
T6751 |
Acetylcholine iodide
Acetylcolina |
Others | Others |
Acetylcholine iodide (Acetylcolina) 是一种在中枢和外周神经系统中常见的神经递质。 | |||
T4808 |
Agmatine sulfate
Agmatine sulfate salt,硫酸胍基丁胺 |
Endogenous Metabolite; NO Synthase; Imidazoline Receptor | Immunology/Inflammation; Metabolism; Neuroscience |
Agmatine sulfate (Agmatine sulfate salt) 是咪唑啉受体的内源性激动剂和一氧化氮合酶抑制剂。它靶向神经递质系统,离子通道和一氧化氮合成。 | |||
T0710 |
L-Cycloserine
Levcycloserine,Levcicloserina,(-)-Cycloserine,(S)-Cycloserine,Levcycloserinum,环丝氨酸,(S)-4-Amino-3-isoxazolidone |
HIV Protease; GABA Receptor | Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
L-Cycloserine ((-)-Cycloserine) 不可逆地抑制大肠杆菌以及各种动物大脑中的 GABA 吡哆醛 5'-磷酸依赖性转氨酶,导致体内抑制性神经递质 γ-氨基丁酸水平升高。 | |||
T6534 |
Histamine dihydrochloride
组胺二盐酸盐,peremin,Ceplene,Histamine 2HCl |
Endogenous Metabolite; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience |
Histamine dihydrochloride (Ceplene) 是 Histamine 的二盐酸形式。Histamine 是一种有机氮化合物,是一种强效的胃分泌兴奋剂,支气管平滑肌收缩剂,血管舒张剂,也是一种中枢作用的神经递质。 | |||
T0965 |
Histamine
Ergamine,组胺 |
5-HT Receptor; Endogenous Metabolite; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience |
Histamine (Ergamine) 是通过组胺的酶促脱羧衍生的胺。它是一种强大的胃分泌兴奋剂、支气管平滑肌的收缩剂、血管扩张剂以及中枢作用的神经递质。 | |||
T2O2731 |
L-Aspartic acid
L-天冬氨酸,L-天冬氨酸;L-天冬碱;L-酰胺天冬酸;L-天冬酰胺一水物,Aspatofort,Asparagic acid |
Others; Endogenous Metabolite | Metabolism; Others |
L-Aspartic acid (Aspatofort) 是一种氨基酸,是结肠特异性药物输送的前体药物。 | |||
T2O2728 |
glycine
2-Aminoacetic acid,Glycolixir,Aminoacetic acid,Glycosthene,Glycocoll,甘氨酸 |
MT Receptor; Endogenous Metabolite; iGluR | Membrane transporter/Ion channel; Metabolism; Neuroscience |
glycine (2-Aminoacetic acid) 是中枢神经系统的抑制性神经递质,也是谷氨酸的联合激动剂,有促进谷氨酸能NMDA 受体兴奋的潜力。它主要存在于明胶和丝素蛋白中,并在治疗上用作营养物质。 | |||
T5292 |
N-Acetyl-L-tyrosine
N-乙酰-L-酪氨酸,N-Acetyltyrosine,Ac-Tyr-OH |
Others; Endogenous Metabolite | Metabolism; Others |
N-Acetyl-L-tyrosine (Ac-Tyr-OH) 是一种来源于AA 乙酰酶作用下的酪氨酸,和芳香族氨基酸脱羧酶缺乏症以及酪氨酸血症有关,能够作为儿茶酚胺的前体,用于治疗神经递质。 | |||
T3095 |
Tyramine
4-hydroxyphenethylamine,酪胺,para-tyramine,p-Tyramine,mydrial,Tocosine,Uteramine |
MAO; Endogenous Metabolite | Metabolism; Neuroscience |
Tyramine (Uteramine) 是天然存在于体内或某些食物中的氨基酸。Tyramine 有助于调节血压。 | |||
T6805 |
Choline bitartrate
2,3,4-trihydroxy-4-oxobutanoate,2-hydroxyethyl(trimethyl)azanium,酒石酸氢胆碱 |
Others; AChR | Neuroscience; Others |
Choline bitartrate (2-hydroxyethyl(trimethyl)azanium) 是一种存在于食物中的营养胆碱,可影响肝脏疾病、动脉粥样硬化和神经系统疾病等疾病。它是神经递质乙酰胆碱的前体,作为甲基供体参与各种代谢过程和脂质代谢。 | |||
T2A2532 |
L-Histidine
Glyoxaline-5-alanine,L-(-)-Histidine,L-组氨酸,histidine,组氨酸,L-Hisidine |
Mitochondrial Metabolism; Endogenous Metabolite | Metabolism |
L-Histidine (L-(-)-Histidine) 是人类生长和组织修复所需的一种半必需氨基酸(儿童应从食物中获得)。 L-Histidine 是线粒体谷氨酰胺转运的抑制剂。 | |||
T1208 |
Citicoline sodium
Citicoline sodium salt,CDP-choline,胞磷胆碱钠 |
Apoptosis; Others; Endogenous Metabolite | Apoptosis; Metabolism; Others |
Citicoline sodium (CDP-choline) 是一种合成细胞膜组分磷脂酰胆碱的中间体,有神经保护作用。 | |||
T6S2227 |
Spinosin
斯皮诺素,Flavoayamenin |
Others | Others |
Spinosin (Flavoayamenin) 是一种具有神经保护作用的 C-糖苷类黄酮,从 Zizyphus jujube 种子分离得到,能够激活 Nrf2/HO-1 通路,并抑制 Aβ1-42的产生和聚合。 | |||
T0647 |
Tryptamine
|
Dehydrogenase; 5-HT Receptor; Endogenous Metabolite; TRP/TRPV Channel | GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Tryptamine 是一种在动物、植物和真菌中发现的单胺生物碱。它含有吲哚环结构,结构类似于色氨酸。在哺乳动物的大脑中发现了微量这种物质,并被认为是一种神经递质或神经调节剂。 | |||
T4439 |
sn-Glycero-3-phosphocholine
Choline Alfoscerate,甘磷酸胆碱,Glycerophosphocholine,Glycerophosphorylcholine,Alpha-GPC,Choline glycerophosphate,L-α-GPC |
Endogenous Metabolite; AChE | Metabolism; Neuroscience |
sn-Glycero-3-phosphocholine (Choline glycerophosphate) 是脑磷脂生物合成的前体,能够提高胆碱在神经组织中的生物利用度。它对认知功能有显著影响,同时具有良好的耐受性和安全性,因此能够用于阿尔茨海默病和痴呆症的研究。 | |||
T4881 |
Phosphorylethanolamine
O-Phosphorylethanolamine,乙醇胺磷酸酯 |
Others; Endogenous Metabolite | Metabolism; Others |
Phosphorylethanolamine (O-Phosphorylethanolamine) 是磷脂代谢的一种磷酸单酯代谢物。Phosphorylethanolamine 是磷脂合成的前体,也是磷脂分解的产物。与其他器官相比,大脑中磷酸单酯的含量要高得多。在大脑发育过程中,磷单酯通常在神经增生期间升高。这也与大脑发育过程中正常的程序性细胞死亡和突触修剪的发生相吻合。这些发现与磷酸单酯在膜生物合成中的作用是一致的。Phosphorylethanolamine 与抑制性神经递质GABA和GABAB受体部分激动剂 3-氨基丙基膦酸具有很强的结构相似性。Phosphorylethanolamine 是一种磷单酯,在阿尔茨海默病患者的大脑中减少。 | |||
T7044 |
Norepinephrine
去甲肾上腺素,Levophed,Levonoradrenaline,Aktamin,Nor-Epirenan,Levonor,Arterenol |
MMP; Endogenous Metabolite; Adrenergic Receptor; Autophagy | Autophagy; GPCR/G Protein; Metabolism; Neuroscience; Proteases/Proteasome |
Norepinephrine (Levophed) 属于生物碱类天然产物,是一种神经递质,一种肾上腺素能受体 (AR) 的激动剂,对 α1、α2 和 β1 AR 具有激活活性。Norepinephrine 被用作抗休克的血管活性剂。 | |||
TN3351 |
Aflatrem
|
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Aflatrem is a tremorgenic mycotoxin with acute neurotoxic effects, a single low dose of aflatrem is able to induce degeneration of neuronal processes in hippocampal neurotransmitter systems. Aflatrem potentiates the gamma-aminobutyric acid (GABA)-induced |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02245 |
SNAP-25 Protein, Human, Recombinant (His)
synaptosomal-associated protein, 25kDa,SEC9,SNAP,RIC-4,dJ106... |
Human | E. coli |
Synaptosomal-associated protein 25, also known as Super protein, Synaptosomal-associated 25 kDa protein, SNAP25 and SNAP, is a cytoplasm and cell membrane protein that belongs to the SNAP-25 family. SNAP25 / SUP contains 2 t-SNARE coiled-coil homology domains. SNAP25 / SUP is a membrane bound protein anchored to the cytosolic face of membranes via palmitoyl side chains in the middle of the molecule. SNAP25 / SUP protein is a component of the SNARE complex, which is proposed to account for the sp... | |||
TMPH-03383 |
Synaptotagmin-12 Protein, Rat, Recombinant (His)
Syt12,Synaptotagmin-12,Synaptotagmin XII,Synaptotagmin-relat... |
Rat | E. coli |
Synaptic vesicle phosphoprotein that enhances spontaneous neurotransmitter release but does not effect induced neurotransmitter release. Unlike other synaptotagmins, it does not bind Ca(2+) or phospholipids. Essential for mossy-fiber long-term potentiation in the hippocampus. Synaptotagmin-12 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 50.7 kDa and the accession number is P97610. | |||
TMPH-02149 |
ALDH5A1 Protein, Human, Recombinant (His)
Succinate-semialdehyde dehydrogenase, mitochondrial,NAD(+)-d... |
Human | P. pastoris (Yeast) |
Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). | |||
TMPH-01564 |
ICA1 Protein, Human, Recombinant (His)
Islet cell autoantigen p69,ICA1,69 kDa islet cell autoantige... |
Human | P. pastoris (Yeast) |
May play a role in neurotransmitter secretion. | |||
TMPY-02025 |
CPLX2 Protein, Human, Recombinant (His)
CPX-2,Hfb1,921-L,complexin 2,CPX2 |
Human | E. coli |
Complexin-2 (CPLX2), a member of the complexin/synaphin family, is a soluble pre-synaptic protein believed to regulate neurotransmitter release from pre-synaptic terminals. Complexins are soluble proteins that regulate the activity of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes necessary for vesicle fusion. Complexins are unable to bind to monomeric SNARE proteins but bind with high affinity to ternary SNARE complexes and with lower affinity to target ... | |||
TMPH-00423 |
Tetanus toxin Protein, Clostridium tetani, Recombinant (B2M & His)
Tentoxylysin,Tetanus toxin,tetX |
Clostridium tetani | E. coli |
Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2. Tetanus toxin Protein, Clostridium tetani, Recombinant (B2M & His) is expressed in E. coli expression... | |||
TMPH-02161 |
Synapsin-1 Protein, Human, Recombinant (GST)
SYN1,Brain protein 4.1,Synapsin I,Synapsin-1 |
Human | E. coli |
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level. | |||
TMPY-01742 |
Acetylcholinesterase Protein, Mouse, Recombinant (His)
Acre,Chrne,acetylcholinesterase (Yt blood group) |
Mouse | HEK293 Cells |
Acetylcholinesterase, also known as ACHE, is an enzyme that degrades (through its hydrolytic activity) the neurotransmitter acetylcholine, producing choline and an acetate group. Acetylcholinesterase plays a crucial role in nerve impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter acetylcholine (ACh). ACHE appears to be a potential therapeutic target at muscle injuries including organophosphate myopathy. It is an externally oriented membrane-bound enzyme and ... | |||
TMPH-01025 |
CALCA Protein, Human, Recombinant (GST)
Calcitonin gene-related peptide 1,CGRP-I,CALCA,CALC1,Alpha-t... |
Human | E. coli |
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP. CALCA Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 30.6 kDa and the accession number is P06881. | |||
TMPH-01368 |
GABRP Protein, Human, Recombinant (His)
GABRP,GABA(A) receptor subunit pi,Gamma-aminobutyric acid re... |
Human | E. coli |
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone. GABRP Protein, Human, Recombinant (His) is expressed in E. coli... | |||
TMPH-03399 |
VAMP2 Protein, Rat, Recombinant (His)
Vesicle-associated membrane protein 2,Vamp2,Synaptobrevin-2 |
Rat | E. coli |
Involved in the targeting and/or fusion of transport vesicles to their target membrane. Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. VAMP2 Protein, Rat, Recombina... | |||
TMPH-01394 |
GRIN1 Protein, Human, Recombinant (His)
N-methyl-D-aspartate receptor subunit NR1,Glutamate [NMDA] r... |
Human | E. coli |
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition. GRIN1 Protein, Human, Recombinant (His)... | |||
TMPH-03741 |
BoNT/F Protein, Clostridium botulinum, Recombinant (His)
Bontoxilysin-F,BoNT/F,botF,Botulinum neurotoxin type F |
Clostridium botulinum | E. coli |
Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes of nerve terminals of the eukaryotic host skeletal and autonomic nervous system, with frequent heart or respiratory failure. Precursor of botulinum neurotoxin F which may have 2 coreceptors; complex polysialylated gangliosides found on neural tissue and specific membrane-anchored proteins found in synaptic vesicles. Receptor proteins are exposed on host presynaptic cell ... | |||
TMPH-02162 |
Synaptotagmin-1 Protein, Human, Recombinant (His)
SYT1,Synaptotagmin-1,p65,Synaptotagmin I |
Human | E. coli |
Calcium sensor that participates in triggering neurotransmitter release at the synapse. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at leas... | |||
TMPY-02340 |
HNMT Protein, Human, Recombinant (GST)
HMT,HNMT-S1,HNMT-S2,histamine N-methyltransferase |
Human | E. coli |
HNMT (Histamine N-methyltransferase) is a Protein Coding gene. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. HNMT, the major enzyme for the metabolism of histamine in the rat brain, is potently inhibited by 9-amino-1,2,3,4-tetrahydroacridine (tacrine). Methylation is an important pathway in the biotransformation of many drugs, neurotransmitters, and xenobiotic compounds. Histamine N-methyltransferase (HNMT) catalyzes the N ... | |||
TMPJ-01379 |
TAC3 Protein, Human, Recombinant (His)
Neurokinin-B,Tachykinin-3,UNQ585/PRO1155,NKNB,ZNEUROK1,TAC3,... |
Human | E. coli |
Tachykinin 3 (TAC3) is a secreted protein that belongs to the Tachykinin family. Tachykinins are active peptides that excite neurons and evoke behavioral responses; they are potent vasodilators and secretagogues, and contract many smooth muscles in pregnancy. TAC3 is primarily expressed in the central and peripheral nervous systems and functions as a neurotransmitter. It is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension ... | |||
TMPY-03445 |
Aspartate Aminotransferase Protein, Human, Recombinant (His)
ASTQTL1,glutamic-oxaloacetic transaminase 1, soluble,cCAT,cA... |
Human | E. coli |
GOT1 (Glutamic-Oxaloacetic Transaminase 1) is a Protein Coding gene. GOT1 belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme that exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. GOT1 is an important regulator of levels of glut... | |||
TMPY-01959 |
Tryptophan Hydroxylase 1/TPH-1 Protein, Human, Recombinant (His)
TPRH,tryptophan hydroxylase 1,TRPH |
Human | E. coli |
Tryptophan 5-hydroxylase 1, also known as Tryptophan 5-monooxygenase 1, Tryptophan hydroxylase 1, TPH1, TPH and TPRH, is an enzyme that belongs to the biopterin-dependent aromatic amino acid hydroxylase family. TPH1 contains one ACT domain. Tryptophan hydroxylase catalyzes the biopterin-dependent monooxygenation of tryptophan to 5-hydroxytryptophan (5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin. It is the rate-limiting enzyme in the biosynthesis of serotonin. ... | |||
TMPY-04422 |
Casein Kinase 1 gamma 2 Protein, Human, Recombinant (His)
CK1g2,casein kinase 1, γ2,casein kinase 1, gamma 2,Casein Ki... |
Human | Baculovirus Insect Cells |
Casein kinase I gamma 2 isoform (CSNK1G2), a member of the large casein kinase I (CKI) subfamily, protein kinase superfamily. It may affect the development of brain, and associate with vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. The CKI family includes several other isoforms (alpha, beta, gamma, and delta). Dishevelled (Dsh), another positive component of the Wnt pathway, becomes phosphorylated in response to Wnt signals. All the CKI isoforms, with the exce... | |||
TMPY-00186 |
GHRH Protein, Human, Recombinant (hFc)
GRF,INN,growth hormone releasing hormone,GHRF |
Human | HEK293 Cells |
The role of hypothalamic growth hormone-releasing hormone (GHRH) in the release of growth hormone (GH) from the pituitary is well established. Extra-hypothalamic growth hormone-releasing hormone (GHRH) plays an important role in infertility. Growth hormone releasing hormone (GHRH) has recently been shown to increase the level of gamma-aminobutyric acid (GABA) and activate GABA receptors (GABARs) in the cerebral cortex. GABA is an inhibitory neurotransmitter that can inhibit seizures. GHRH may pl... | |||
TMPH-01248 |
ADAR Protein, Human, Recombinant (His & SUMO)
ADAR1,IFI-4,136 kDa double-stranded RNA-binding protein,Inte... |
Human | E. coli |
Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences duri... | |||
TMPH-02631 |
PRKN Protein, Mouse, Recombinant (GST)
E3 ubiquitin-protein ligase parkin,Prkn,Parkin RBR E3 ubiqui... |
Mouse | E. coli |
Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2. Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or det... | |||
TMPH-01263 |
PRKN Protein, Human, Recombinant (His & SUMO)
PRKN,Parkin RBR E3 ubiquitin-protein ligase,E3 ubiquitin-pro... |
Human | E. coli |
Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2. Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or det... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T39565 |
L-Glutamic acid-15N
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L-Glutamic acid-15N is the 15N-labeled version of L-Glutamic acid, an excitatory neurotransmitter and an agonist at metabotropic, kainate, NMDA, and AMPA glutamate receptor subtypes. It directly activates the release of dopamine (DA) from dopaminergic terminals. | |||
TMIJ-0056 |
DL-Epinephrine-d6
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DL-Epinephrine-d6 是 DL-Epinephrine 的氘代化合物。DL-Epinephrine 的 CAS 号为 329-65-7。DL-Adrenalin 是一种激素和神经递质。 | |||
TMID-0059 |
DL-Epinephrine-d3
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DL-Epinephrine-d3 是 DL-Epinephrine 的氘代化合物。DL-Epinephrine 的 CAS 号为 329-65-7。DL-Adrenalin 是一种激素和神经递质。 | |||
TMID-0299 |
Zonisamide-d4
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Zonisamide-d4 是 Zonisamide 的氘代化合物。Zonisamide 的 CAS 号为 68291-97-4。Zonisamide 是锌酶碳酸酐酶 (carbonic anhydrase) 的有效抑制剂,对人类线粒体同工酶 hCA II 和 hCA V 作用的Ki值分别为 35.2 nM 和 20.6 nM。Zonisamide 具有抗癫痫活性,在癫痫、癫痫发作和帕金森病的研究中具有价值。 | |||
TMID-0176 |
4-Aminobutyric acid-2,2,3,3,4,4-d6
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4-Aminobutyric acid-2,2,3,3,4,4-d6 是 4-Aminobutyric acid 的氘代化合物。4-Aminobutyric acid 的 CAS 号为 56-12-2。γ-Aminobutyric acid 是成年哺乳动物大脑中主要的抑制性神经递质,能够与离子移变 GABA 受体 (GABAA) 受体和促代谢受体 (GABAB) 受体结合发挥作用。 | |||
TMIH-0205 |
Duloxetine-d3 HCl
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Duloxetine-d3 HCl 是 Duloxetine HCl 的氘代化合物。Duloxetine HCl 的 CAS 号为 136434-34-9。Duloxetine hydrochloride 是一种 5-羟色胺-去甲肾上腺素重吸收 (serotonin-norepinephrine reuptake) 抑制剂 (SNRI),Ki=4.6 nM,可用于广泛性焦虑症的研究。 | |||
TMIJ-0078 |
Glycine-d2
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Glycine-d2 是 Glycine 的氘代化合物。Glycine 的 CAS 号为 56-40-6。Glycine 是中枢神经系统的抑制性神经递质,也是谷氨酸的联合激动剂,有促进谷氨酸能NMDA受体兴奋的潜力。它主要存在于明胶和丝素蛋白中,并在治疗上用作营养物质。 | |||
TMID-0170 |
Homotaurine-d6
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Homotaurine-d6 是 Homotaurine 的氘代化合物。Homotaurine 的 CAS 号为 3687-18-1。Homotaurine 是一种具有口服活性的、可透过血脑屏障的天然氨基酸,存在于各种红色海藻中,能够可溶性 Aβ 结合并以非原纤维形式维持 Aβ。它是一种 GABA 类似物,具有神经保护,抗惊厥和抗高血压的活性。 |