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Search Results for " hippocampus "

Targets Recommended: AChR

49

抑制剂 & 化合物

4

天然产物

19

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T23513	VU10010 VU 10010	AChR	Neuroscience
	VU10010 (VU 10010) 是一种高度选择性的M4mAChR 变构增强剂，EC50为 400 nM。它与 M4mAChR 的变构位点结合，增强与 G 蛋白偶联，增加对乙酰胆碱的亲和力，还会增加卡巴胆碱引起的兴奋性传导抑制。
T1566	Aripiprazole 阿立哌唑,OPC-14597	5-HT Receptor	GPCR/G Protein; Neuroscience
	Aripiprazole (OPC-14597) 是血清素受体 5-HT1A 和多巴胺 D2 受体的部分激动剂，还用作突触后拮抗剂和血清素受体 5-HT2A 的拮抗剂。
T19333	Gadoteridol ProHance,SQ-32692,钆特醇,Gd-HP-DO3A	Others	Others
	Gadoteridol (Gd-HP-DO3A) 是含钆基的 MRI 造影剂，可用于中枢神经系统成像。
T8702	SKF-83566	Dopamine Receptor; 5-HT Receptor; AChR	GPCR/G Protein; Neuroscience
	SKF-83566 是一种具有血脑渗透性和口服活性的 D1 样多巴胺受体拮抗剂和一种较弱的竞争性 5-HT2 受体拮抗剂，Ki 为 11 nM。它是竞争性多巴胺转运蛋白抑制剂，可用于研究帕金森氏症和对尼古丁渴望的缓解的相关研究。
T4297	Flibanserin BIMT-17BS,氟立班丝氨,Girosa,BIMT-17	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Flibanserin (Girosa) 一种具有口服活性的 5-HT1A 受体激动剂和 5-HT2A 受体拮抗剂，Ki 值分别为 1 和 49 nM。它与多巴胺 D4 受体结合，Ki 值在 4 到 24 nM 之间。它是一种血清素能抗抑郁药，用于治疗性欲减退症。
T12617L	(R)-CR8 (R)-CR8,(R)-Isomer,(2R)-2-[[9-异丙基-6-[[[4-(2-吡啶基)苯基]甲基]氨基]-9H-嘌呤-2-基]氨基]-1-丁醇,CR8	Apoptosis; CDK	Apoptosis; Cell Cycle/Checkpoint
	(R)-CR8 ((R)-Isomer) 是 Roscovitine 类似物，是CDK1/2/5/7/9抑制剂。它作为一种分子胶降解剂来消耗细胞周期蛋白 K。它诱导细胞凋亡并具有神经保护作用。
T5468	YF-2	Others; Epigenetic Reader Domain; Histone Acetyltransferase	Chromatin/Epigenetic; Others
	YF-2 是一种高选择性，可透过血脑屏障的组蛋白乙酰转移酶激动剂，能够在海马区乙酰化 H3，对 CBP、PCAF 和 GCN5 的EC50值分别为 2.75、29.04 和 49.31 μM，具有抗肿瘤和抗阿尔滋海默症的活性。
T16816	S 18986	GluR	Neuroscience
	S 18986是一种选择性、可口服活性、能渗透大脑的AMPA型受体阳性异构体调节剂，在啮齿动物中展示出增强认知的特性。它在大鼠海马体内诱导去甲肾上腺素和乙酰胆碱的释放，从而提高了对象识别记忆能力。
T11800	L-803087	Somatostatin	GPCR/G Protein
	L-803087 是一种具有高效性和选择性的生长抑素 sst4 受体激动剂，对 sst4 的 Ki 值为 0.7 nM，比其他生长抑素受体的选择性高 280 倍以上。L-803087 在体外诱导 AMPA 介导的海马突触反应，在体内增加了海藻酸盐促使的小鼠癫痫发作。
T37547	trans-Urocanic Acid trans-UCA,(E)-Urocanic acid
	trans-Urocanic Acid ((E)-Urocanic acid) 是一种主要分布于海马体和前额叶皮层的化合物，是顺式UCA的异构体，是表皮紫外线保护剂，可增强替诺福韦艾拉酚胺在长效HIV应用中的稳定性。trans-urocanic acid 可有效调节免疫功能，可在体外抑制人类自然杀伤细胞的活性，可用于研究阿尔茨海默病。
T37190	L-Allylglycine	Dehydrogenase; GABA Receptor	Membrane transporter/Ion channel; Metabolism; Neuroscience
	L-Allylglycine 是 GABA 合成酶（谷氨酸脱羧酶）的有效抑制剂。
T13975	ZSET-845	Others	Others
	ZSET-845 is an enhancer of cognitive which enhances choline acetyltransferase activity in the hippocampus in the rat.
T61934	Repinotan BAY x 3702 free base	5-HT Receptor	GPCR/G Protein; Neuroscience
	Repinotan (BAY x 3702 free base) 是一种可透过血脑屏障（BBB)且具有口服活性和选择的 5-HT1A 受体激动剂，具有神经保护活性，可拮抗吗啡诱导的麻醉大鼠通气抑制，可用于研究急性缺血性中风和创伤性脑损伤。
T28139	NCFP	Others	Others
	NCFP is a mGlu5 positive allosteric modulator. It positively modulates mGlu5 without the induction of long-term potentiation and long-term depression in the hippocampus.
T10542	Bifeprunox	Others	Others
	Bifeprunox is a potent partial agonist of dopamine D2-like and 5-HT1A receptor (pEC50: 6.37 for hippocampus 5-HT1A; pKis: 7.19 and 8.83 for cortex 5-HT1A and striatum D2). It is an antipsychotic for the research of schizophrenia.
TP1685	Cortistatin-14 TFA (186901-48-4 free base) Cortistatin-14 TFA
	Cortistatin-14 is a neuropeptide have structural similarity to somatostatin-14. It is produced in the cortex and hippocampus of central nervous system.
TP1188	Cortistatin 14, human, rat CST-14, human, rat
	Cortistatin 14 is a somatastatin-like neuropeptide with neuronal depressant and sleep modulating properties. Cortistatin 14 is present primarily in the cortex and hippocampus.
T25558	JNJ-55511118 JNJ 55511118	Others	Others
	JNJ-55511118 is a selective negative modulator of AMPA receptors containing TARP-γ8 (Ki: 26 nM). It had excellent pharmacokinetic properties. JNJ-55511118 exhibited a dose-dependent inhibition of neurotransmission within the hippocampus and a strong antic
T24919	UBP714 UBP 714,UBP-714	Others	Others
	UBP714 is a derivative of the NMDA receptor negative allosteric modulator UBP608. It also enhanced NMDAR mediated field EPSPs in the CA1 region of the hippocampus. UBP714 is a novel template for the development of potent and subunit selective NMDAR potent
T38281	C22 Galactosylceramide (d18:1/22:0)	Others	Others
	C22 Galactosylceramide is a sphingolipid that has been found in the central nervous system.1,2C22 Galactosylceramide levels are increased in the spinal cord, but not the brain or liver, of mice fed a methionine-restricted diet.1C22 Galactosylceramide has been found in postmortem hippocampus from patients with Alzheimer's disease.2[Matreya, LLC.]
T36178	Aspalatone	Others	Others
	Aspalatone is an anti-platelet aggregator (IC50 = 180 μM, in vitro) that prolongs bleeding time significantly in a rodent model of thromboembolism. Additionally at a minimal effective dose of 24 mg/kg, aspalatone generates antioxidant and neuroprotective effects against kainic acid-induced epilepsy in rat hippocampus.
T38217	1-Stearoyl-2-Adrenoyl-sn-glycero-3-PE	Others	Others
	1-Stearoyl-2-adrenoyl-sn-glycero-3-PE is a phospholipid that contains stearic acid and adrenic acid at thesn-1 andsn-2 positions, respectively. 1-Stearoyl-2-adrenoyl-sn-glycero-3-PE levels are inversely correlated with subject age in mitochondria isolated from human post-mortem hippocampus.1 1.Hancock, S.E., Friedrich, M.G., Mitchell, T.W., et al.Decreases in phospholipids containing adrenic and arachidonic acids occur in the human hippocampus over the adult lifespanLipids50(9)861-872(2015)
T70365	JTP-4819	Others	Others
	JTP-4819 is a potent and selective prolyl endopeptidase (PEP) inhibitor with potential for treating Alzheimer's disease. At nanomolar concentration, JTP-4819 inhibited the degradation of substance P, arginine-vasopressin, and thyrotropin-releasing hormone by PEP in supernatants of the rat cerebral cortex and hippocampus. Repeated administration of JTP-4819 reversed the aging-induced decrease in brain substance P-like and thyrotropin-releasing hormone-like immunoreactivity, suggesting that this d...
T61130	SSTR4 agonist 3	Others	Others
	SSTR4 agonist 3 is a potent compound that activates the SSTR4 receptor. The SSTR4 receptor is highly expressed in the hippocampus and neocortex, which are regions associated with memory, learning, and Alzheimer's disease pathology. SSTR4 agonists demonstrate strong efficacy in rodent models of pain, both acute and chronic, by reducing peripheral nociception and inflammation. Considering its potential application in pain research, SSTR4 agonist 3 is of interest[1].
T38711	YF-2 hydrochloride	Others	Others
	YF-2 hydrochloride is a potent histone acetyltransferase activator that exhibits high selectivity and can pass through the blood-brain barrier. It specifically acetylates H3 in the hippocampus, with EC50 values of 2.75 μM, 29.04 μM, and 49.31 μM for CBP, PCAF, and GCN5, respectively. Notably, it does not affect HDAC activity. Moreover, YF-2 hydrochloride demonstrates promising anti-cancer and anti-Alzheimer's disease properties.
T70595	Artemisinin B	Others	Others
	Artemisinin B is a drug which may improve spatial memory in dementia patients and alter the levels of inflammatory cytokines in the hippocampus and the cortex. Artemisinin B may inhibit neuroinflammation and exert neuroprotective effects on cognitive functions by modulating the TLR4-MyD88-NF-κB signaling pathway. Artemisinin B has shown potential in the treatment of neuroinflammatory diseases.
TP1662	Galanin Receptor Ligand M35
	The chimeric peptide M35 [galanin (1-13)-bradykinin(2-9) amide] is a high-affinity galanin receptor ligand acting as a galanin receptor antagonist in the rat spinal cord, rat hippocampus and isolated mouse pancreatic islets. The radiolabelled M35 and perf
T37478	Acetyl β-Endorphin (1-26) (human) (trifluoroacetate salt)
	Acetyl β-endorphin (1-26) is a neuropeptide found in rat hippocampus, brain stem, and pituitary. It is also present in the human hypothalamus, where it comprises approximately 4.9% of total β-endorphin peptides. Acetyl β-endorphin (1-26) is produced through posttranslational processing of β-endorphin and is processed similarly in rat and human hypothalamus. Levels of acetyl β-endorphin (1-26) increase in the rat pars intermedia and brain stem following chronic administration of haloperidol .
T35809	C20 Sphingomyelin (d18:1/20:0)	Others	Others
	C20 Sphingomyelin is a naturally occurring sphingolipid. Levels of C20 sphingomyelin are upregulated in the hippocampus of rats with diabetes induced by streptozotocin and in human plasma where it is positively correlated with insulin resistance in obese humans. C20 sphingomyelin is also upregulated in the liver of a mouse model of Niemann-Pick type C1 disease, a neurodegenerative cholesterol-sphingolipid lysosomal storage disorder. The plasma concentration of C20 sphingomyelin is decreased in m...
T76358	Neuropeptide Y (1-24) (human)
	Neuropeptide Y (1-24) (human) 是一种神经肽，它能够抑制大鼠输精管电刺激引发的抽搐反应，同时在体内刺激 N-methyl-D-aspartate (NMDA) 促使大鼠海马背侧 CA3 区神经元激活。
T80170	Tamapin	Potassium Channel	Membrane transporter/Ion channel
	Tamapin为靶向小电导Ca(2+)激活的K(+) (SK)通道的毒液肽，尤以钾通道SK2为选择性阻断剂。该化合物能够抑制海马锥体神经元SK通道介导的电流，来源于印度红蝎(Mesobuthus tamulus)。
TP2136	(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin
	Selective vasopressin V1A receptor antagonist. Inhibits vasopressin and oxytocin-induced increases in intracellular calcium concentrations in vitro (IC50 values are 5 and 30 nM respectively). Exhibits potent and prolonged antivasopressor activity and indu
T28653	S-8510 free base SB 737552,SB-737552,S8510,SB737552,S-8510,S 8510	Others	Others
	S-8510 is a GABA-A receptor inverse agonist. S-8510 selectively potentiated pentylenetetrazol-induced convulsion without affecting minimal electroconvulsive shock- or strychnine-induced convulsion in ddY mice. S-8510 ameliorated memory impairment induced
T76221	Leptin (116-130)
	Leptin(116-130)是一种生物活性的瘦素片段，能促进AMPA受体运输至突触并加强活动依赖性的海马突触可塑性。此外，Leptin(116-130)在抗淀粉样蛋白毒性模型中有效阻止海马突触损伤和神经元细胞死亡，显示出对研究阿尔茨海默病(AD)具有重要潜力。
T36521	Alaproclate (hydrochloride)	Others	Others
	Alaproclate is a selective serotonin reuptake inhibitor (SSRI).1,2 It inhibits depletion of serotonin (5-HT) induced by 4-methyl-α-ethyl-m-tyramine in rat cerebral cortex, hippocampus, hypothalamus, and striatum (EC50s = 18, 4, 8, and 12 mg/kg, respectively).1 Alaproclate inhibits NMDA-evoked currents and depolarization-induced voltage-dependent potassium currents in rat hippocampal neurons (IC50s = 1.1 and 6.9 μM, respectively) and does not inhibit GABA-evoked currents when used at concentratio...
T80185	Huwentoxin I HWTX-I	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Huwentoxin I (HWTX-I)为一种肽毒素，针对电压门控钠通道和N型钙通道具有抑制作用。该化合物对大鼠海马神经元和蟑螂DUM神经元的钠离子通道展现出抑制能力，其IC50值分别为66.1 nM和4.80 nM。
T60911	SSTR4 agonist 4	Others	Others
	SSTR4 agonist 4 是一种有效的SSTR4激动剂，具有用于疼痛研究的潜力。SSTR4 激动剂在与急性和慢性相关的抗外周伤害感受和抗炎活性相关疼痛的啮齿动物模型中有效。SSTR4 在海马和新皮质、记忆和学习区域以及阿尔茨海默病病理学中的表达水平相对较高。
T76493	(Glu2)-TRH
	(Glu2)-TRH 是一种代谢稳定的 Thyrotropin-releasing hormone(TRH) 类似物，是小鼠大脑中 TRH 胆碱能作用的负调节剂。(Glu2)-TRH 显着减弱 TRH 诱导的海马细胞外乙酰胆碱释放。(Glu2)-TRH 不被甲状腺解放酶代谢。(Glu2)-TRH 在中枢神经系统中表现出神经保护、抗抑郁、抗惊厥作用。
T35663	Cortistatin-29 (rat) (trifluoroacetate salt)	Others	Others
	Cortistatin-29 is a neuropeptide that is structurally similar to somatostatin-28. It is produced by cleavage of preprocortistatin to procortistatin, which is cleaved at dibasic amino acids to form cortistatin-29 and cortistatin-14 as well as other partial cleavage products. Cortistatin mRNA is expressed in the human brain and in interneurons of the rat hippocampus and cerebral cortex. Cortistatin-29 binds to somatostatin (SST) receptors with IC50 values of 2.8, 7.1, 0.2, 3, and 13.7 nM for SST1-...
T73511	SZM679	RIP kinase	Apoptosis; NF-κB
	SZM679是一种口服有效的选择性RIPK1抑制剂，其对RIPK1的Kd值为8.6 nM，而对RIPK3的Kd值则大于5000 nM。该化合物能够逆转肿瘤坏死因子诱导的全身炎症反应，并在海马和皮质中降低Tau蛋白的过度磷酸化、神经炎症以及RIPK1磷酸化水平。SZM679可用于阿尔茨海默病（AD）的研究。
T70063	GYKI 52466 HCl	Others	Others
	GYKI 52466 is an allosteric AMPA receptor antagonist. It selectively inhibits AMPA-induced inward currents (IC50 = 7.5 µM) over NMDA- or GABA-induced inward currents in primary rat hippocampal neurons at 50 µM but also inhibits kainate-induced inward currents in the same cells (IC50 = 11 µM).2 GYKI 52466 (10 µM) reduces the amplitude of spontaneous excitatory postsynaptic currents (EPSCs) in the same cells. It increases the latency to seizure onset and reduces mortality in a rat model of general...
T61930	Yhhu-3792	Others	Others
	Yhhu-3792 激活 Notch 信号通路并促进 Hes3 和 Hes5 的表达。Yhhu-3792 增强神经干细胞 (NSC) 的自我更新能力，扩大了 NSC 池并促进了小鼠海马齿状回部分 (DG) 的内源性神经形成。Yhhu-3792 可提高小鼠的情景和空间记忆能力。 Yhhu-3792 在记忆障碍相关 DG 功能障碍中具有研究潜力。
T11827	Pradigastat ANJ908,LCQ908-NXA,LCQ908A,LCQ-908	Transferase	Metabolism
	Pradigastat (LCQ-908) 是一种具有口服活性、有效性和选择性的二酰基甘油酰基转移酶 1 (DGAT1) 抑制剂，可用于治疗便秘，可用于研究肥胖和糖尿病。
T79718	CaMKIIα-PHOTAC	CaMK	Neuroscience
	CaMKIIα-PHOTAC是一种靶向Ca2+/钙调蛋白依赖性蛋白激酶IIα（CaMKIIα）的光化学靶向嵌合体（PHOTAC）。该分子在特定波长光照射下实现靶蛋白的泛素化及通过蛋白酶体催化的降解。CaMKIIα-PHOTAC能在光照条件下显著降低小鼠海马区域的诱发LTP反应强度，减弱突触功能，并对维护亚细胞级别的树突结构域、长时程增强及记忆能力起到关键作用。
T83909	6-hydroxy Buspirone BMY 28674,BMS-52821
	6-hydroxy Buspirone是抗焦虑化合物buspirone的活性代谢产物，通过细胞色素P450（CYP）亚型CYP3A4从buspirone转化而来。该化合物在大鼠海马和背侧缝核的5-羟色胺（5-HT）受体亚型5-HT1A上具有亲和力（EC50s分别为4和1 µM），并作为多巴胺D2、D3、D4受体拮抗剂（IC50s分别为3.1、4.9、和0.85 µM）。同时，它还以浓度依赖性方式抑制表达人类转运体的S2近端小管细胞中的有机阳离子转运体1（OCT1）、OCT2和OCT3。
T37718	Galanin (rat, mouse) (trifluoroacetate salt) GAL (rat, mouse),Galanin (rat, mouse) (trifluoroacetate salt)
	Galanin is a neuropeptide with diverse biological activities. [1][2][3][4][5] It binds to rat galanin (GAL) receptor subtypes GAL1-3 (IC50s = 0.339, 1.35, and 3.31 nM, respectively) and human GAL1-3 (IC50s = 0.288, 1.62, and 12.3 nM, respectively). [1] Galanin binds to and inhibits contraction of guinea pig gastric smooth muscle cells induced by carbachol . [2] In vivo, Galanin (6 nmol, i.c.v.) increases feeding behavior in rats and increases latency to hindpaw withdrawal in response to heat and...
T38145	Eltoprazine	Others	Others
	Eltoprazine(DU28853) is a serenic or antiaggressive agent which as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor.IC50 value:Target: 5-HT1A/1B agonist; 5-HT2C antagonistin vitro: The binding of [3H]eltoprazine to whole tissue sections was saturable and revealed an apparent dissociation constant (Kd) of 11 nM. Specific [3H]eltoprazine binding was completely displaced by 5-HT; conversely, unlabelled eltoprazine reduced [3H]5-HT binding to the levels of no...
T36947	Pyrithiamine (hydrobromide)	Others	Others
	Pyrithiamine is the pyridine analog of thiamine that prevents growth of organisms that require intact thiamine. [1] It inhibits the growth of bacterial and fungal species at a pyrithiamine:thiamine ratio of 10:1 in growth media and induces symptoms of thiamine deficiency in mice at a dietary ratio of 3:1. These effects are reversible with addition of sufficient thiamine in all species. Pyrithiamine inhibits the formation of cocarboxylase from thiamine in chicken blood in a dose-dependent manner....
T10360	AR-A 2 AR-A 000002	Others	Others
	AR-A 2 is a selective 5-HT1B receptor antagonist, with a high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki: 0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT1D receptor (Ki: 5 nM).

化合物

Cat.No: T23513

Synonym: VU 10010

Target: AChR

Cat.No: T1566

Synonym: 阿立哌唑,OPC-14597

Target: 5-HT Receptor

Cat.No: T19333

Synonym: ProHance,SQ-32692,钆特醇,Gd-HP-DO3A

Target: Others

Cat.No: T8702

Target: Dopamine Receptor, 5-HT Receptor, AChR

Cat.No: T4297

Synonym: BIMT-17BS,氟立班丝氨,Girosa,BIMT-17

Target: Dopamine Receptor, 5-HT Receptor

Cat.No: T12617L

Synonym: (R)-CR8,(R)-Isomer,(2R)-2-[[9-异丙基-6-[[[4-(2-吡啶基)苯基]甲基]氨基]-9H-嘌呤-2-基]氨基]-1-丁醇,CR8

Target: Apoptosis, CDK

Cat.No: T5468

Target: Others, Epigenetic Reader Domain, Histone Acetyltransferase

Cat.No: T16816

Target: GluR

Cat.No: T11800

Target: Somatostatin

trans-Urocanic Acid

Cat.No: T37547

Synonym: trans-UCA,(E)-Urocanic acid

Cat.No: T37190

Target: Dehydrogenase, GABA Receptor

Cat.No: T13975

Target: Others

Cat.No: T61934

Synonym: BAY x 3702 free base

Target: 5-HT Receptor

Cat.No: T28139

Target: Others

Cat.No: T10542

Target: Others

Cortistatin-14 TFA (186901-48-4 free base)

Cat.No: TP1685

Synonym: Cortistatin-14 TFA

Cortistatin 14, human, rat

Cat.No: TP1188

Synonym: CST-14, human, rat

Cat.No: T25558

Synonym: JNJ 55511118

Target: Others

Cat.No: T24919

Synonym: UBP 714,UBP-714

Target: Others

C22 Galactosylceramide (d18:1/22:0)

Cat.No: T38281

Target: Others

Cat.No: T36178

Target: Others

1-Stearoyl-2-Adrenoyl-sn-glycero-3-PE

Cat.No: T38217

Target: Others

Cat.No: T70365

Target: Others

SSTR4 agonist 3

Cat.No: T61130

Target: Others

YF-2 hydrochloride

Cat.No: T38711

Target: Others

Cat.No: T70595

Target: Others

Galanin Receptor Ligand M35

Cat.No: TP1662

Acetyl β-Endorphin (1-26) (human) (trifluoroacetate salt)

Cat.No: T37478

C20 Sphingomyelin (d18:1/20:0)

Cat.No: T35809

Target: Others

Neuropeptide Y (1-24) (human)

Cat.No: T76358

Cat.No: T80170

Target: Potassium Channel

(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin

Cat.No: TP2136

S-8510 free base

Cat.No: T28653

Synonym: SB 737552,SB-737552,S8510,SB737552,S-8510,S 8510

Target: Others

Leptin (116-130)

Cat.No: T76221

Alaproclate (hydrochloride)

Cat.No: T36521

Target: Others

Cat.No: T80185

Synonym: HWTX-I

Target: Calcium Channel

SSTR4 agonist 4

Cat.No: T60911

Target: Others

Cat.No: T76493

Cortistatin-29 (rat) (trifluoroacetate salt)

Cat.No: T35663

Target: Others

Cat.No: T73511

Target: RIP kinase

Cat.No: T70063

Target: Others

Cat.No: T61930

Target: Others

Cat.No: T11827

Synonym: ANJ908,LCQ908-NXA,LCQ908A,LCQ-908

Target: Transferase

CaMKIIα-PHOTAC

Cat.No: T79718

Target: CaMK

6-hydroxy Buspirone

Cat.No: T83909

Synonym: BMY 28674,BMS-52821

Galanin (rat, mouse) (trifluoroacetate salt)

Cat.No: T37718

Synonym: GAL (rat, mouse),Galanin (rat, mouse) (trifluoroacetate salt)

Cat.No: T38145

Target: Others

Pyrithiamine (hydrobromide)

Cat.No: T36947

Target: Others

Cat.No: T10360

Synonym: AR-A 000002

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T3767	Polygalacic acid Virgaureagenin G,毛果一枝黄花皂苷元G,远志酸	MMP; AChR; AChE	Neuroscience; Proteases/Proteasome
	Polygalacic acid (Virgaureagenin G) 是一种从远志 Polygala tenuifolia Willd 根中分离出来的三萜，可抑制 MMP 表达。它对认知障碍有显著的神经保护作用，PA 通过抑制乙酰胆碱酯酶活性，增加胆碱乙酰转移酶活性，提高海马和额皮质中的乙酰胆碱水平来提高胆碱能系统反应性。它可以用于骨关节炎相关研究。
T6S2227	Spinosin 斯皮诺素,Flavoayamenin	Others	Others
	Spinosin (Flavoayamenin) 是一种具有神经保护作用的 C-糖苷类黄酮，从 Zizyphus jujube 种子分离得到，能够激活 Nrf2/HO-1 通路，并抑制 Aβ1-42的产生和聚合。
T4956	Tetrahydroxystilbene-2-O-β-D-glucoside tetrahydroxyl diphenylethylene-2-o-gluco,何首乌苷,EH-201	Others	Others
	Tetrahydroxystilbene-2-O-β-D-glucoside (EH-201) 是一种低分子量的促红细胞生成素诱导剂。
T3779	Crocin II Crocin 2,西红花苷II,Crocetin gentiobiosylglucosyl ester,藏红花,Tricrocin,Crocin B	Caspase; COX; NO Synthase	Apoptosis; Immunology/Inflammation; Neuroscience; Proteases/Proteasome
	Crocin II (Crocetin gentiobiosylglucosyl ester) 是从栀子果实中分离出来的一种天然产物，具有抗氧化、抗癌和抗抑郁活性。它抑制 iNOS 和 COX-2的蛋白质和 m-RNA 的表达，还抑制NO 产生，IC50值为 31.1 μM。

天然产物

Polygalacic acid

Cat.No: T3767

Synonym: Virgaureagenin G,毛果一枝黄花皂苷元G,远志酸

Target: MMP, AChR, AChE

Cat.No: T6S2227

Synonym: 斯皮诺素,Flavoayamenin

Target: Others

Tetrahydroxystilbene-2-O-β-D-glucoside

Cat.No: T4956

Synonym: tetrahydroxyl diphenylethylene-2-o-gluco,何首乌苷,EH-201

Target: Others

Cat.No: T3779

Synonym: Crocin 2,西红花苷II,Crocetin gentiobiosylglucosyl ester,藏红花,Tricrocin,Crocin B

Target: Caspase, COX, NO Synthase

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-05510	BDNF Protein, Mouse, Recombinant (His) brain-derived neurotrophic factor	Mouse	HEK293 Cells
	BDNF is a member of thenerve growth factorfamily. It is highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. It also can be detected in heart, lung, skeletal muscle, testis, prostate and placenta. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. During development, BDNF promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. It participates in axonal growth,...
TMPH-02555	C1QL1 Protein, Mouse, Recombinant (His) C1q and tumor necrosis factor-related protein 14,Complement ...	Mouse	P. pastoris (Yeast)
	May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses.
TMPH-02862	Wnt8b Protein, Mouse, Recombinant (His & Myc & SUMO) Wnt8b,Protein Wnt-8b	Mouse	E. coli
	Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus.
TMPY-03053	Ezrin Protein, Human, Recombinant (His) HEL-S-105,CVL,VIL2,CVIL,ezrin	Human	E. coli
	VIL2, also known as villin-2, belongs to the ERM protein family. It is expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. VIL2 contains 1 FERM domain and may be involved in connections of major cytoskel
TMPH-03383	Synaptotagmin-12 Protein, Rat, Recombinant (His) Syt12,Synaptotagmin-12,Synaptotagmin XII,Synaptotagmin-relat...	Rat	E. coli
	Synaptic vesicle phosphoprotein that enhances spontaneous neurotransmitter release but does not effect induced neurotransmitter release. Unlike other synaptotagmins, it does not bind Ca(2+) or phospholipids. Essential for mossy-fiber long-term potentiation in the hippocampus. Synaptotagmin-12 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 50.7 kDa and the accession number is P97610.
TMPJ-00818	ALDOC Protein, Human, Recombinant (His) Aldolase C,ALDC,zebrin II,Aldo3,Scrg2,Fructose-bisphosphate ...	Human	HEK293 Cells
	Fructose-bisphosphate aldolase C (ALDOC) belongs to the class I fructose-bisphosphate aldolase family. It is an enzyme that, in humans, is encoded by the ALDOC gene. ALDOC is expressed exclusively in the hippocampus and Purkinje cells of the brain. ALDOC is a glycolytic enzyme which catalyzes the reversible aldol cleavage of fructose-1,6-biphosphate and fructose 1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde-3-phosphate or glyceraldehydes respectively
TMPH-02600	C1QL3 Protein, Mouse, Recombinant (His & Myc) C1ql,Gliacolin,C1q and tumor necrosis factor-related protein...	Mouse	Baculovirus Insect Cells
	May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC1 and PCK1 and hence decreases de novo glucose production.
TMPY-04463	CDKL2 Protein, Human, Recombinant (His) KKIAMRE,P56,cyclin-dependent kinase-like 2 (CDC2-related kin...	Human	Baculovirus Insect Cells
	Cyclin-dependent kinase-like 2 (Cdkl2) is a member of cdc2-related serine / threonine protein kinase family and it is found expressed in various brain regions, including the cerebral cortex, entorinal cortex, hippocampus, amygdala, and dorsal thalamus. The high expression in these brain regions suggests that Cdkl2 may have functions in congnition and emotion processes. Cdkl2 accumulates primarily in the cytoplasm, with lower levels in the nucleus.
TMPJ-00709	LY6H Protein, Human, Recombinant (His) Ly-6H,LY6H,Lymphocyte Antigen 6H	Human	HEK293 Cells
	Lymphocyte Antigen 6H (LY6H) is a novel member of the LY6 family of glycosylphosphatidylinositol-anchored cell surface glycoproteins. LY6H contains one UPAR/Ly6 domain. Human LY6H is synthesized as a 140 amino acid precursor that contains a 25 amino acid signal sequence, 20 amino acid propeptide that is removed in the mature form, and a 90 amino acid mature chain. LY6H is highly expressed in the brain (cerebral cortex, amygdala, hippocampus and subthalamic nucleus) and in acute human leukemic ce...
TMPJ-00916	TIMP-2 Protein, Mouse, Recombinant (His) metalloproteinase inhibitor 2,Tissue inhibitor of metallopro...	Mouse	HEK293 Cells
	Mouse Metalloproteinase inhibitor 2(TIMP-2), belongs to a family of proteins that regulate the activation and proteolytic activity of matrix metalloproteinases (MMPs). There are four mammalian members of the family; TIMP‑1, TIMP‑2, TIMP‑3, and TIMP‑4. The TIMP-2 is detected in testis, retina, hippocampus and cerebral cortex. The function of TIMP 2 protein is to inhibit MMPs non covalently by the formation of binary complexes. Complexes with metalloproteinases (such as collagenases) and irreversi...
TMPY-04373	CAMKII alpha/CAMK2A Protein, Human, Recombinant (GST) calcium/calmodulin-dependent protein kinase II alpha,calcium...	Human	Baculovirus Insect Cells
	Ca2+/calmodulin-dependent protein kinase2A (CAMK2A) belongs to the serine/threonine protein kinase family and, together with other 28 different isoforms, belongs to the Ca2+/ calmodulin-dependent protein kinase subfamily. CaM kinase Ⅱ is thought to be an important mediator of learning and memory and is also necessary for Ca2+homeostasis and reuptake in cardiomyocytes chloride transport in epithelia, positive T-cell selection, and CD8 T-cell activation. CAMKIIA is one of the major forms of CAMKII...
TMPY-03410	TMEM25 Protein, Human, Recombinant (His) bA83N9.1,transmembrane protein 25	Human	HEK293 Cells
	TMEM25 is a novel member of the immunoglobulin superfamily. Immunoglobulin superfamily members are implicated in immune responses, growth factor signaling, and cell adhesion. TMEM25 contains 1 Ig-like (immunoglobulin-like) domain and is a target of pharmacogenomics in the field of oncology and regenerative medicine. TMEM25 isoform 1, consisting of exons 1-9, encoded a 366-aa transmembrane protein. TMEM25 isoform 2, consisting of exons 1-4 and 6-9, encoded a 322-aa secreted protein. TMEM25 mRNA w...
TMPJ-00858	Ezrin Protein, Human, Recombinant Villin-2,VIL2,EZR,p81,Ezrin,Cytovillin	Human	E. coli
	Ezrin is expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. The N-terminus of ezrin contains a FERM domain which is further subdivided into three subdomains. The C-terminus contain a ERM domain. As a member of the ERM protein family, Ezrin serves as an intermediate between the plasma membrane and the actin cytoskeleton. It plays a key role in cell surface structure adhesion, migration, and organization. Ezrin probably involved in connections of major cytoskele...
TMPJ-00614	CD47 Protein, Rhesus macaque, Recombinant (His & Flag) MER6,Integrin-Associated Protein,IAP,Leukocyte Surface Antig...	Rhesus	HEK293 Cells
	CD47, also known as Integrin‑Associated Protein (IAP) and OA3, is a glycosylated atypical member of the immunoglobulin superfamily. Mouse CD47 is an integral membrane protein that consists of a extracellular domain (ECD) with a single Ig‑like domain, five membrane-spanning regions with short intervening loops, and C‑terminal cytoplasmic tail. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. It plays an important r...
TMPY-01479	SPG3A Protein, Human, Recombinant (GST) HSN1D,atlastin GTPase 1,FSP1,atlastin1,GBP3,SPG3,SPG3A,AD-FS...	Human	Baculovirus Insect Cells
	Atlastin-1, also known as Spastic paraplegia 3 protein A, Guanine nucleotide-binding protein 3, GTP-binding protein 3, GBP3, ATL1 and SPG3A, is a multi-pass membrane protein which belongs to theGBP family and atlastin subfamily. ATL1 / SPG3A is expressed predominantly in the adult and fetal central nervous system. Expression of ATL1 / SPG3A in adult brain is at least 5-fold higher than in other tissues. ATL1 / SPG3A is detected predominantly in pyramidal neurons in the cerebral cortex and...
TMPY-01927	ANP32A Protein, Human, Recombinant (His & GST) MAPM,PP32,I1PP2A,C15orf1,LANP,HPPCn,PHAPI,acidic (leucine-ri...	Human	E. coli
	acidic leucine-rich nuclear phosphoprotein 32 family member A, also known as acidic nuclear phosphoprotein pp32, Leucine-rich acidic nuclear protein, Mapmodulin, Potent heat-stable protein phosphatase 2A inhibitor I1PP2A, Putative HLA-DR-associated protein I, PHAPI and ANP32A, is a nucleus, cytoplasm and endoplasmic reticulum. ANP32A / LANP is expressed in all tissues tested. It is highly expressed in kidney and skeletal muscle, moderate levels of expression is in brain, placenta and panc...
TMPY-01992	Kallikrein 8/KLK8 Protein, Human, Recombinant (His) kallikrein-related peptidase 8,PRSS19,TADG14,NRPN,NP,HNP	Human	HEK293 Cells
	Kallikrein-8, also known as Neuropsin, Serine protease 19, Serine protease TADG-14, Tumor-associated differentially expressed gene 14 protein, and KLK8 is a secreted protein that belongs to the peptidase S1 family and Kallikrein subfamily. It is a serine protease that is capable of degrading some proteins such as casein, fibrinogen, kininogen, fibronectin, and collagen type IV. Kallikrein-8 / KLK8 plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-c...
TMPH-02317	YTHDF1 Protein, Human, Recombinant (His) YTHDF1,Dermatomyositis associated with cancer putative autoa...	Human	P. pastoris (Yeast)
	Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and regulates their stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex. The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) shares m6A-containing mRNAs targets and act redundantly to mediate mRNA degradatio...
TMPH-01282	ELAVL4 Protein, Human, Recombinant (His & Myc & SUMO) PNEM,ELAVL4,HuD,Hu-antigen D,ELAV-like protein 4	Human	E. coli
	RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs. Plays a role in the regulation of mRNA stability, alternative splicing and translation. Binds to AU-rich element (ARE) sequences in the 3' untranslated region (UTR) of target mRNAs, including GAP43, VEGF, FOS, CDKN1A and ACHE mRNA. Many of the target mRNAs are coding for RNA-binding proteins, transcription factors and proteins involved in RNA processing and/or neuronal development and function. By binding to th...

重组蛋白

BDNF Protein, Mouse, Recombinant (His)

Cat.No: TMPY-05510

Species: Mouse

Expression System: HEK293 Cells

C1QL1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02555

Species: Mouse

Expression System: P. pastoris (Yeast)

Wnt8b Protein, Mouse, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-02862

Species: Mouse

Expression System: E. coli

Ezrin Protein, Human, Recombinant (His)

Cat.No: TMPY-03053

Species: Human

Expression System: E. coli

Synaptotagmin-12 Protein, Rat, Recombinant (His)

Cat.No: TMPH-03383

Species: Rat

Expression System: E. coli

ALDOC Protein, Human, Recombinant (His)

Cat.No: TMPJ-00818

Species: Human

Expression System: HEK293 Cells

C1QL3 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02600

Species: Mouse

Expression System: Baculovirus Insect Cells

CDKL2 Protein, Human, Recombinant (His)

Cat.No: TMPY-04463

Species: Human

Expression System: Baculovirus Insect Cells

LY6H Protein, Human, Recombinant (His)

Cat.No: TMPJ-00709

Species: Human

Expression System: HEK293 Cells

TIMP-2 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00916

Species: Mouse

Expression System: HEK293 Cells

CAMKII alpha/CAMK2A Protein, Human, Recombinant (GST)

Cat.No: TMPY-04373

Species: Human

Expression System: Baculovirus Insect Cells

TMEM25 Protein, Human, Recombinant (His)

Cat.No: TMPY-03410

Species: Human

Expression System: HEK293 Cells

Ezrin Protein, Human, Recombinant

Cat.No: TMPJ-00858

Species: Human

Expression System: E. coli

CD47 Protein, Rhesus macaque, Recombinant (His & Flag)

Cat.No: TMPJ-00614

Species: Rhesus

Expression System: HEK293 Cells

SPG3A Protein, Human, Recombinant (GST)

Cat.No: TMPY-01479

Species: Human

Expression System: Baculovirus Insect Cells

ANP32A Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-01927

Species: Human

Expression System: E. coli

Kallikrein 8/KLK8 Protein, Human, Recombinant (His)

Cat.No: TMPY-01992

Species: Human

Expression System: HEK293 Cells

YTHDF1 Protein, Human, Recombinant (His)

Cat.No: TMPH-02317

Species: Human

Expression System: P. pastoris (Yeast)

ELAVL4 Protein, Human, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-01282

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T71142	Tebuconazole-d9
	Tebuconazole-d9 is intended for use as an internal standard for the quantification of tebuconazole by GC- or LC-MS. Tebuconazole is a triazole fungicide that is active against both seed and foliar fungi. It inhibits 14α-demethylase isolated from U. maydis and S. bicolor with IC50 values of 0.05 and 0.16 nM, respectively. It inhibits the androgenic effect of the androgen receptor agonist DHT (IC20 = 2.89 µM) and is cytotoxic (EC20 = 38.9 µM) in an MDA-kb2 assay. Tebuconazole (50 and 100 mg/kg per...

同位素标记化合物

Tebuconazole-d9

Cat.No: T71142

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