137
30
1
83
5
Cat. No. | Product Name | ||
---|---|---|---|
L2550 | 谷氨酰胺代谢化合物库 | 565 compounds | |
565 种谷氨酰胺代谢相关的分子,可以用于高通量和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2013 |
Ponalrestat
|
Reductase | Endocrinology/Hormones; Metabolism |
Ponalrestat 是一种口服有效的,选择性的和非竞争性的醛糖还原酶抑制剂,对 ALR2选择性选择性较高,Ki 为 7.7 nM, 对 ALR1 的选择性较弱,Ki 为 60 μM。Ponalrestat 抑制葡萄糖向山梨糖醇的转化。 | |||
T8490 |
Butoconazole
1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole,布康唑 |
Antifungal | Microbiology/Virology |
Butoconazole (1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole) 是一种咪唑类抗真菌药物,可治疗白色念珠菌引起的阴道感染。它可通过抑制类固醇起抗菌作用。 | |||
T13584 |
BMVC-8C3O
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
BMVC-8C3O 是一种 DNA G-四链体 (G4) 配体,可诱导人类端粒 DNA G4 中的非平行到平行形式的拓扑转换 | |||
T2061 |
APY0201
|
PI3K; Interleukin | Immunology/Inflammation; PI3K/Akt/mTOR signaling |
APY0201 是PIKfyve 抑制剂,能够抑制 PtdIns3P 转化为PtdIns(3,5)P2 (IC50:5.2 nM),还能够抑制IL-12/IL-23产生。 | |||
T2148 |
Carbidopa monohydrate
Carbidopa Hydrate,S(-)-Carbidopa,卡比多巴水合物 |
Decarboxylase; Aryl Hydrocarbon Receptor | Immunology/Inflammation; Metabolism; Others |
Carbidopa monohydrate (S(-)-Carbidopa) 是一种外周型脱羧酶抑制剂,可用于帕金森病的研究。它是一种选择性芳香烃受体 (AhR) 调节剂。它抑制胰腺癌细胞和肿瘤生长。 | |||
T3281 |
Delapril hydrochloride
indalapril,地拉普利盐酸盐,Alindapril Hydrochloride,Delapril Hydrochloride,盐酸地拉普利,CV 3317 |
RAAS | Endocrinology/Hormones |
Delapril hydrochloride (indalapril) 是一种血管紧张素转化酶抑制剂,能够用于心血管疾病的研究。 | |||
T77507 |
(-)-Benzotetramisole
|
Others | Others |
(-)-Benzotetramisole 使一种高效且具有选择性的催化剂。(-)-Benzotetramisole 是抗蠕虫化合物四咪唑3 的苯annulated 衍生物,本身也是转化的有效催化剂。 | |||
T4049 |
Genz-123346 free base
|
Glucokinase | Metabolism |
Genz-123346 free base 是一种能够阻断神经酰胺向GL1转化的GL1合酶的抑制剂,其抑制GM1的IC50值为14 nM。 | |||
T23550 |
YM-750
YM 750 |
Acyltransferase | Metabolism |
YM-750 是一种有效的酰基:胆固醇酰基转移酶(ACAT)抑制剂,IC50为0.18 μM。 | |||
T27832 |
Lifibrol
U 83860,K-12148,K-12.148,U-83860,K12148 |
Lipid | Metabolism |
Lifibrol (U-83860) 是一种胆固醇合成抑制剂。Lifibrol 具有抗胆固醇和降血脂的作用,可促进高胆固醇血症和混合型高脂血症患者体内低密度脂蛋白载脂蛋白 B-100 的转化。 | |||
T0961 |
Trometamol
三(羟甲基)氨基甲烷,Tromethamine,缓血酸铵 |
COX | Immunology/Inflammation; Neuroscience |
Trometamol (Tromethamine) 是一种在生理范围内控制 pH 值的有效胺类化合物,也是一种低毒性的生物惰性氨基醇,可以在体内和体外缓冲二氧化碳和酸。 | |||
T1462 |
Captopril
SQ 14225,甲巯丙脯酸,卡托普利,SQ-14534,SA333 |
RAAS | Endocrinology/Hormones |
Captopril (SA333) 是一种含巯基的,具有口服活性的血管紧张素转换酶(ACE)抑制剂 ,IC50=0.025 μM,广泛应用于高血压和充血性心力衰竭的研究。Captopril 也是NDM-1抑制剂,IC50=7.9 μM。 | |||
T1736 |
Apixaban
阿哌沙班,BMS-562247-01 |
Factor Xa | Metabolism |
Apixaban (BMS-562247-01) 是一种高度选择性,可逆的、口服具有活力的凝血因子 Xa (Factor Xa) 抑制剂,抑制人和兔凝血因子 Xa 的 Ki 分别为 0.08 nM 和 0.17 nM。它可以用于研究各种血栓栓塞疾病。 | |||
T2134 |
Dorzolamide hydrochloride
MK507 hydrochloride,L671152 hydrochloride,MK-507 (L-671152) HCl,盐酸多佐胺,Dorzolamide HCl |
Carbonic Anhydrase | Metabolism |
Dorzolamide hydrochloride (MK507 hydrochloride) 是一种碳酸酐酶carbonic anhydrase II 抑制剂,能够抑制红细胞CA-II(IC50:0.18 nM) 和CA-I(IC50:600 nM) 。 | |||
T8987 |
Epiblastin A
|
Casein Kinase | Metabolism; Stem Cells |
Epiblastin A 是 ATP 竞争性的酪蛋白激酶 1 (CK1) 抑制剂,能够抑制 CK1α (IC50:8.9 µM)、 CK1δ (IC50:0.5 µM)、CK1 ɛ (IC50:4.7 µM)。它能够抑制 CK1 诱导外胚层干细胞重编程为胚胎干细胞。 | |||
T1484L |
Perindopril erbumine
培哚普利叔丁胺,培哚普利叔丁胺盐,S9490-3,Perindopril tert-butylamine salt |
Apoptosis; RAAS; MRP | Apoptosis; Endocrinology/Hormones; Immunology/Inflammation |
Perindopril erbumine (S9490-3) 是一种长效血管紧张素转换酶抑制剂。 | |||
T1790 |
Fosaprepitant dimeglumine
福沙匹坦二甲葡胺,L785298,福沙吡坦二甲葡胺,MK-0517,Fosaprepitant dimeglumine salt |
Neurokinin receptor | GPCR/G Protein; Neuroscience |
Fosaprepitant dimeglumine (MK-0517) 是 Aprepitant 的前药。它是一种神经激肽 1 受体拮抗剂,可用于预防化疗引起的恶心呕吐。 | |||
T20339 |
7-Hydroxymethotrexate
NSC 380963,NSC-380963,NSC380962,NSC380963,NSC 380962,NSC-380962 |
Drug Metabolite | Metabolism |
7-Hydroxymethotrexate 是 Methotrexate 主要的代谢产物。Methotrexate 对叶酸具有抑制作用,抑制二氢叶酸还原酶,从而防止叶酸转化为四氢叶酸,并抑制 DNA 合成。Methotrexate 对代谢也具有抑制作用。 | |||
T72814 |
11β-HSD1-IN-12
|
Dehydrogenase | Metabolism |
11β-HSD1-IN-12 是一种11β-HSD1抑制剂。11β-HSD1 可从非活性形式再生活性糖皮质激素,在调节细胞内糖皮质激素浓度方面很重要。11β-HSD1-IN-12 可用于肥胖和代谢综合征的研究。 | |||
T16510 |
PF-915275
|
Dehydrogenase | Metabolism |
PF-915275 是口服有效的人 11β-羟基类固醇脱氢酶1型选择性抑制剂,Ki 为 2.3 nM,在 HEK293 细胞中的EC50为 15 nM 。它对人和猴原代肝细胞中可的松向皮质醇的转化具有剂量依赖性,EC50分别为 20 nM 和 100 nM。 | |||
T77379 |
Bexmarilimab
FP-1305 |
Others | Others |
Bexmarilimab (FP-1305) 是一种高效的人源化抗 CLEVER-1 IgG4 抗体,其 IC50 值为 4.51 nM。Bexmarilimab 能够促使肿瘤相关巨噬细胞表型 M2 到 M1 的免疫转换。Bexmarilimab 可用于研究癌症。 | |||
T1438 |
Butoconazole nitrate
RS 35887,硝酸布康唑 |
Estrogen/progestogen Receptor; Antifungal | Endocrinology/Hormones; Microbiology/Virology |
Butoconazole nitrate (RS 35887) 是一种咪唑类抗真菌药物,可治疗由白色念珠菌引起的阴道感染。它可通过抑制类固醇合成起到抗菌作用。 | |||
T28482 |
Firibastat
QGC 001,QGC-001,RB-150,RB150,QGC001,RB 150 |
Aminopeptidase | Metabolism |
Firibastat (RB150) 是一种具有口服活性的 EC33 前体药物。Firibastat 是一种首创的脑氨基肽酶 A(APA) 抑制剂 (Ki=200 nM),选择性地抑制高血压大鼠脑血管紧张素 II 转化为血管紧张素 III,降低血压。 | |||
T0196 |
Diclofenac
双氯芬酸,奥尔芬,Diclofenacum,Voltaren |
Apoptosis; COX | Apoptosis; Immunology/Inflammation; Neuroscience |
Diclofenac (Diclofenacum) 是一种具有抗炎活性的非甾体苯乙酸衍生物,是 COX 抑制剂,在 CHO 细胞中,对人 COX-1 和 COX-2 的 IC50值分别为 4 和 1.3 nM。它对绵羊 COX-1 和 COX-2 的 IC50值分别为 5.1 μM,0.84 μM。它通过活化 caspase 级联反应来诱导神经干细胞凋亡。 | |||
T1184 |
Rivaroxaban
BAY 59-7939,利伐沙班 |
Factor Xa; Thrombin | Metabolism; Proteases/Proteasome |
Rivaroxaban (BAY 59-7939) 是高效选择性的凝血因子 Xa (FXa) 直接抑制剂,IC50=0.7 nM,Ki 为 0.4 nM。 | |||
T4281 |
Endoxifen
(E/Z)-N-desmethyl-4-hydroxy Tamoxifen,N-去甲基-4-羟基-,(E/Z)-Endoxifen |
Estrogen Receptor/ERR; Aromatase; Estrogen/progestogen Receptor; Parasite; Drug Metabolite | Endocrinology/Hormones; Metabolism; Microbiology/Virology |
Endoxifen ((E/Z)-Endoxifen) 是 Tamoxifen 的关键活性代谢物,能抑制芳香酶的活性,与雌激素受体有较高的亲和力和特异性。它有潜力研究乳腺癌。 | |||
T1574 |
Etoricoxib
Arcoxia,MK-663,Tauxib,L-791456,Nucoxia,Desvenlafaxine,依托考昔 |
COX | Immunology/Inflammation; Neuroscience |
Etoricoxib (MK-663) 是一种合成的非甾体抗炎药 (NSAID),具有解热、镇痛和潜在的抗肿瘤特性。它是可口服的选择性 COX-2抑制剂,对人全血 COX-2 和 COX-1 的 IC50值分别为 1.1 和 116 μM。 | |||
T14878 |
CAY10566
|
Dehydrogenase; Stearoyl-CoA Desaturase (SCD) | Metabolism |
CAY10566 是选择性的、口服具有活性的硬脂酰辅酶 A 去饱和酶 1 抑制剂,在小鼠和人酶测定中IC50分别为 4.5 和 26 nM。它具有显著的细胞活性,可阻断 HepG2 细胞中饱和长链脂肪酸-CoAs (LCFA-CoAs) 向单不饱和 LCFA-CoAs 的转化 。 | |||
TP1115 |
L-Asparaginase
L-ASNase |
Others | Others |
L-Asparaginase (L-ASNase) 是催化 L-天冬酰胺转化的水解酶,从血浆中去除 L-天冬酰胺,导致 RNA 和 DNA 合成抑制,随后引起细胞凋亡。它用于急性淋巴细胞白血病的研究。 | |||
T1185 |
Rofecoxib
MK 966,罗非昔布,罗非考昔,MK-0966 |
COX | Immunology/Inflammation; Neuroscience |
Rofecoxib (MK 966) 是可口服的 COX-2特异性抑制剂,具有抗炎、解热和镇痛特性以及潜在的抗肿瘤特性。在人骨肉瘤细胞和中国仓鼠卵巢细胞中,对人 COX-2 的 IC50值分别为 26 和 18 nM。 | |||
T1139 |
Salbutamol
Albuterol,沙丁胺醇,AH-3365 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Salbutamol (Albuterol) 是短效的 β2 肾上腺素受体激动剂,用于哮喘和慢性阻塞性肺疾病(COPD) 引发的支气管痉挛的研究。 | |||
T1676 |
Rosuvastatin
罗伐他汀,ZD 4522,瑞舒伐他汀 |
Potassium Channel; HMG-CoA Reductase; Autophagy | Autophagy; Membrane transporter/Ion channel; Metabolism |
Rosuvastatin (ZD 4522) 是一种抗血脂药,可竞争性抑制羟甲基戊二酰辅酶 A 还原酶,用于降低血浆胆固醇水平和预防心血管疾病。它降低低密度脂蛋白胆固醇、甘油三酯和 C-反应蛋白水平。它阻断人类醚-a-go-go 相关基因电流,IC50为 195 nM,延迟心脏复极化,延长动作电位持续时间和校正 QT 间期间隔。 | |||
T71703L |
Isomer-Turosteride
Isomer-Turosteride(Isomer-137099-09-3) |
Reductase | Endocrinology/Hormones; Metabolism |
Isomer-Turosteride (Isomer-Turosteride(Isomer-137099-09-3)) 是一种新型 5α- 还原酶抑制剂。Isomer-Turosteride 在成年大鼠中的抗前列腺作用与抑制T向 DHT 的转化有关。Isomer-Turosteride引起前列腺 DHT 的降低,与 T 含量的继发性增加无关。Isomer-Turosteride 具有抗癌活性,可抑制肿瘤细胞的生长。 | |||
T4039 |
BIBB 515
|
Others | Others |
BIBB 515 是口服具有活力的 2,3-氧化角鲨烯环化酶选择性抑制剂,在大鼠和小鼠中的 ED50值分别为 0.2-0.5 mg/kg 和 0.36-33.3 mg/kg (1-5 小时)。它主要利用抑制低密度脂蛋白的产生,从而发挥降脂作用。 | |||
T37190 |
L-Allylglycine
|
Dehydrogenase; GABA Receptor | Membrane transporter/Ion channel; Metabolism; Neuroscience |
L-Allylglycine 是 GABA 合成酶(谷氨酸脱羧酶)的有效抑制剂。 | |||
T25127 |
Azalanstat
RS-21607,RS 21607,RS21607 |
Others | Others |
Azalanstat is a lanosterol 14 alpha-demethylase inhibitor. The enzyme catalyzes the first step in the conversion of lanosterol to cholesterol in mammals. | |||
T32539 |
Laidlomycin propionate
|
Others | Others |
Laidlomycin propionate improves the rate of gain and feed conversion in both steers and heifers. | |||
T1574L |
Etoricoxib HCl
L-791456 monohydrochloride salt,L791456 hydrochloride,L-791456 hydrochloride,L 791456 hydrochloride,Etoricoxib hydrochloride |
Others | Others |
Etoricoxib HCl is a synthetic, nonsteroidal anti-inflammatory drug. Etoricoxib specifically binds to and inhibits the enzyme cyclooxygenase-2, resulting in inhibition of the conversion of arachidonic acid into prostaglandins. | |||
T3281L |
Delapril
Alindapril |
Others | Others |
Delapril is an ACE inhibitor. It blocks the conversion of angiotensin I to angiotensin II. | |||
T40841 |
L-2-Aminooxy-3-phenylpropanoic acid hydrobromide
|
Others | Others |
L-2-Aminooxy-3-phenylpropanoic acid hydrobromide is a powerful inhibitor of L-phenylalanine ammonia-lyase, an enzyme responsible for catalyzing the conversion of L-phenylalanine to trans-cinnamic acid. | |||
T70209 |
Nepicastat hydrochloride monohydrate
|
Others | Others |
Nepicastat hydrochloride monohydrate is an inhibitor of dopamine beta-hydroxylase, an enzyme that catalyzes the conversion of dopamine to norepinephrine. | |||
T11070L |
DO34
|
Others | Others |
DO34 is a highly potent and centrally active inhibitor of diacylglycerol lipase (IC50: 6 nM for DAGLα conversion of SAG to 2-AG). | |||
T40852 |
(Rac)-γ-Tocopherol
(Rac)-γ-Tocopherol,DMPBQ |
Others | Others |
(Rac)-γ-Tocopherol (DMPBQ) is an isoform of Vitamin E that undergoes conversion to γ-Tocopherol through the action of tocopherol cyclase. | |||
T1517L |
Benserazide
Ro-44602,Ro44602,Ro 44602,Serazide |
Others | Others |
Benserazide is an inhibitor of dopa decarboxylase. It is often given with levodopa in the treatment of Parkinson's to prevent the conversion of levodopa to dopamine in the periphery, thereby increasing the amount that reaches the central nervous system an | |||
T27119 |
Daglutril
SLV306,SLV 306,SLV-306 |
Others | Others |
Daglutril, a NEP/ECE inhibitor, is potentially used for the treatment of hypertension, heart failure andpulmonary. Daglutril inhibits systemic conversion of big endothelin-1 in humans. | |||
T76115 |
Pyruvate kinase
|
Others | Others |
Pyruvate kinase 是一种糖酵解酶,催化磷酸烯醇式丙酮酸和 ADP 转化为丙酮酸和 ATP。 | |||
T85007 |
10(S)-HOME
HOD |
Others | Others |
10(S)-HOME, an oxylipin, acts as an intermediate in the conversion process of oleic acid into the antibacterial hydroxy fatty acid 7,10-dihydroxy-8(E)-octadecenoic acid within P. aeruginosa. | |||
T34084 |
Plastoquinone
Q 254,Q-254,Q254 |
Others | Others |
Plastoquinone is a polyunsaturated side-chain quinone derivative which is an important link in the electron transport chain of green plants during the photosynthetic conversion of light energy by photophosphorylation into the potential energy of chemical | |||
T76106 |
Glycerol phosphate dehydrogenase
|
Others | Others |
Glycerol phosphate dehydrogenase 催化磷酸二羟丙酮转化为 α-甘油磷酸。 | |||
T11389 |
Genz-123346
|
Others | Others |
Genz-123346 blocks the conversion of ceramide to glucosylceramide (GL1) and inhibits GM1 with an IC50 value of 14 nM. Genz-123346 is a potent, orally available glucosylceramide synthase inhibitor. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4888 |
Phosphocreatine disodium hydrate
磷酸肌酸二钠盐,Phosphocreatine disodium salt hydrate |
Others; Endogenous Metabolite | Metabolism; Others |
Phosphocreatine disodium hydrate 是内源性代谢产物的一种。 | |||
T3793 |
(20R)-Ginsenoside Rh1
20(R)-Ginsenoside Rh1,人参皂苷 R-RH1,人参皂苷R-RH1 |
Others | Others |
(20R)-Ginsenoside Rh1 (20(R)-Ginsenoside Rh1) 是 Ginsenoside Rh1 的 R 型异构体,分离自 Panax Ginseng 中,能够阻碍凝血酶诱导的纤维蛋白原向纤维蛋白的转化。 | |||
T20255 |
L-Galactose
Galactose, L- |
Endogenous Metabolite | Metabolism |
L-Galactose (Galactose, L-) 是一种天然产物,广泛存在动植物体内。L-Galactose 在Pistia stratiotes 中被证明是D-葡萄糖转化为草酸的分子途径中的关键中间体。 | |||
T4929 |
L-2-Phosphoglyceric acid
L-GLYCERATE 3-PHOSPHATE 二钠盐,L-2-Phosphoglyceric acid disodium salt h |
Others; Endogenous Metabolite | Metabolism; Others |
L-2-Phosphoglyceric acid (L-2-Phosphoglyceric acid disodium salt) 是内源性代谢产物的一种。 | |||
T5755 |
Aloesin
|
Tyrosinase | Proteases/Proteasome |
Aloesin 是芦荟的活性成分之一,能够通过 MAPK 信号通路发挥抗癌作用,并具有抗炎、紫外线保护和抗菌作用。 | |||
T0610 |
Piceatannol
白皮杉醇,trans-Piceatannol,Astringenin |
Apoptosis; Serine/threonin kinase; PKA; Syk; PKC; Autophagy | Angiogenesis; Apoptosis; Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism; Tyrosine Kinase/Adaptors |
Piceatannol (Astringenin) 是一种Syk 抑制剂,可降低由 TNF 诱导的 iNOS 表达,可研究急性肺损伤。它是存在于各种水果和蔬菜中天然存在的多酚二苯乙烯,可诱导细胞自噬和凋亡,具有抗癌和抗炎特性。 | |||
T4811 |
D-Alanine
D-α-Alanine,Ba 2776,(R)-Alanine,D-丙氨酸,(R)-2-Aminopropionic acid |
Chloride channel; Endogenous Metabolite | Membrane transporter/Ion channel; Metabolism |
D-Alanine ((R)-Alanine) 是一种GlyR 和PMBA 的弱激动剂,其对GlyR 的EC50=9 mM。 | |||
T4726 |
D-Glucose 6-phosphate sodium
G6P sodium salt,D-Glucose 6-phosphate sodium salt,D-葡萄糖-6-磷酸钠盐,Sodium Glucose-6-Phosphate |
Others; Endogenous Metabolite | Metabolism; Others |
D-Glucose 6-phosphate sodium (G6P sodium salt) 是内源性代谢产物的一种。 | |||
T1664 |
Meglutol
Dicrotalic acid,3-Hydroxy-3-methylglutaric acid,美格鲁托 |
Endogenous Metabolite; HMG-CoA Reductase; Autophagy | Autophagy; Metabolism |
Meglutol (3-Hydroxy-3-methylglutaric acid) 是一种抗血脂剂,可降低胆固醇、甘油三酯、血清 β-脂蛋白和磷脂。它抑制胆固醇生物合成中的限速酶羟甲基戊二酰辅酶 A 还原酶的活性。 | |||
T10938 |
D-Kynurenine
D-尿嘧啶,(R)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid,ZINC901103 |
GPR; AhR; Endogenous Metabolite | Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Metabolism |
D-Kynurenine (ZINC901103) 是 D-色氨酸的代谢物和 GPR109B 的激动剂。 D-Kynurenine 激活 AhR 并促进上皮细胞向间充质的转化。 D-Kynurenine 在 D-氨基酸氧化酶的荧光分析中用作底物。 | |||
T4887 |
3-Amino-2-methylpropanoic acid
DL-3-AMINOISOBUTYRIC ACID,3-氨基异丁酸,α-Methyl-β-alanine |
Endogenous Metabolite | Metabolism |
3-Amino-2-methylpropanoic acid (α-Methyl-β-alanine) 是 N-carbamyl-beta-aminoisobutyric acid 经 enzyme Beta-ureidopropionase (EC 3.5.1.6)转化后的产物,是嘧啶降解的最后一步。-尿嘧啶丙酸酶缺乏症是一种与神经异常相关的嘧啶降解的先天性错误。 | |||
T5069 |
D-Glucose 6-phosphate potassium salt
|
Others | Others |
在细胞中,当葡萄糖被己糖激酶或葡萄糖激酶磷酸化或在糖原分解过程中通过磷酸葡萄糖变位酶转化葡萄糖 1-磷酸时,会产生D-glucose 6-phosphate (G6P)。 G6P 位于糖酵解和戊糖磷酸途径的起点。当血糖水平高时,它也可以作为糖原储存。 | |||
T3578 |
Pyridoxal phosphate
PLP,PAL-P,磷酸吡哆醛,pyridoxal 5'-phosphate,Pyridoxyl phosphate,Pyridoxal 5′-phosphate,Vitamin B6 phosphate |
Reverse Transcriptase; Endogenous Metabolite | Metabolism; Microbiology/Virology |
Pyridoxal phosphate (Vitamin B6 phosphate) 是维生素 B6 的活性形式,可抑制逆转录酶活性,用于研究迟发性运动障碍症。 | |||
T5079 |
Adenosine 5'-diphosphate sodium salt
腺苷-5‘-二磷酸钠盐,Adenosine-5'-diphosphate trisodium salt,ADP sodium salt |
Others; Endogenous Metabolite | Metabolism; Others |
Adenosine 5'-diphosphate sodium salt (ADP sodium salt) 是一种核苷二磷酸,是一种 ATP 酶对 ATP 去磷酸化的产物。它通过在 P2T-嘌呤受体上的作用诱导人血小板聚集并抑制刺激的腺苷酸环化酶。 | |||
T2P2923 |
Stearic acid
硬脂酸,Isostearic acid,Octadecanoic acid,Cetylacetic acid |
Phosphatase; Endogenous Metabolite | Metabolism |
Stearic acid (Cetylacetic acid) 是长链饱和脂肪酸,存在于许多动植物油脂中。 | |||
T1591 |
Ancitabine hydrochloride
NSC 145668 HCl,盐酸环胞苷,Cyclocytidine hydrochloride,Cyclo-CMP hydrochloride,Cyclocytidine HCl,Cyclo-C |
Others; DNA/RNA Synthesis; Autophagy | Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others |
Ancitabine hydrochloride (NSC 145668 HCl) 是一种天然的抗白血病药物。 | |||
T4877 |
L-Homocystine
|
Endogenous Metabolite | Metabolism |
L-Homocystine 是一种 L-homocysteine 的氧化物。其中 L-homocysteine 是抗血栓因子、血管舒张损害剂、促炎因子,也是研究心血管疾病发生机制的内质网应激反应的诱导剂。 | |||
T4858 |
4-Hydroxyphenylpyruvic acid
4-羟苯基丙酮酸,4-Hydroxyphenylpyruvic acid |
Endogenous Metabolite | Metabolism |
4-Hydroxyphenylpyruvic acid 是一种苯丙氨酸代谢的中间产物,是一种酶抑制剂。 | |||
TN2769 |
2-Hydroxynaringenin
|
Others | Others |
The recombinant protein exhibits high FNS I activity catalyzing the conversion of naringenin to apigenin and 2-Hydroxynaringenin. | |||
T37774 |
Thielavin A
|
Others | Others |
Thielavin A is a fungal metabolite originally isolated from T. terricola that is related to thielavin B . Thielavin A inhibits COX, blocking both the conversion of arachidonic acid to prostaglandin H2 and the conversion of PGH2 to PGE2 . Thielavin A also inhibits glucose-6-phosphatase in rat liver microsomes (IC50 = 4.6 μM). It is a non-competitive inhibitor of α-glucosidase from S. cerevisiae (IC50 = 23.8 μM; Ki = 27.8 μM). | |||
TN1655 |
Ganoderal A
|
Others | Others |
The oxygenated sterols( 26-oxygenosterols ganoderol A, ganoderol B, ganoderal A, and ganoderic acid Y) from G. lucidum can inhibit cholesterol biosynthesis via conversion of acetate or mevalonate as a precursor of cholesterol. | |||
T82445 |
Erinacine P
|
||
Erinacine P(化合物1)为担子菌猴头菇YB4-6237菌丝体分离得到的木犀草素亲代代谢产物。其在温和条件下可化学转化为猴头素B,继而可转化为猴头素A。 | |||
T78471 |
α,α-Trehalose 6-phosphate potassium
Tre6P potassium |
Endogenous Metabolite | Metabolism |
α,α-Trehalose 6-phosphate (Tre6P) potassium 是一种α,α′-trehalose的6-磷酸衍生物及内源代谢物。在Tre6P磷酸酶 (T6PP) 的催化下,α,α-Trehalose 6-phosphate可被高效转化为α,α′-trehalose。 | |||
TN1751 |
Hydroxycitric acid
|
ERK; p38 MAPK; Fatty Acid Synthase | MAPK; Metabolism |
(-)-Hydroxycitric acid (HCA) can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to act as a competitive inhibitor of the enzyme ATP-citrate lyase, which catalyzes the conversion of citrate and coenzyme A to oxaloacetate and acetyl coenzyme A (acetyl-CoA), primary building blocks of fatty acid and cholesterol synthesis. | |||
T35710 |
N-Acetyl-S-allyl-L-cysteine
|
Others | Others |
L-Deoxyalliin , also known as S-allyl-L-cysteine, is a water soluble organosulfur compound derived from garlic that has neuroprotective and antioxidative activities. N-Acetyl-S-allyl-L-cysteine is a principal metabolite of L-deoxyalliin in humans, mice, rats, and dogs. It is readily detected in plasma and urine. The conversion of L-deoxyalliin to N-acetyl-S-allyl-L-cysteine appears to be mediated by a family of flavin-containing monooxygenases. | |||
T83416 |
2-(Methylamino)benzoic acid
N-Methylanthranilic acid |
||
2-(Methylamino)benzoic acid 为 methyl-N-methylanthranilates (MMA) 的主要代谢物,系通过酯基转化形成。此化合物可从柑橘中提取,并具备潜在的镇痛功能。2-(Methylamino)benzoic acid 亦应用于监测大鼠肝脏中 MMA 的代谢情况。 | |||
T35415 |
α-D-Glucose-1,6-bisphosphate (potassium salt hydrate)
|
Others | Others |
α-D-Glucose-1,6-bisphosphate is abis-phosphorylated derivative of α-D-glucose that has roles in carbohydrate metabolism.1It is the product of the reaction of glucose-1- or 6-phosphate with glucose-1,6-bisphosphate synthase (PGM2LI) in the conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate.2It is also a cofactor for the bacterial enzyme phosphopentomutase.3,4α-D-Glucose-1,6-bisphosphate has been used in the study of carbohydrate metabolism. 1.Beitner, R.Regulation of carbohydrate metabol... | |||
T75576 |
Solidagonic acid
|
Others | Others |
Solidagonic acid 通过促进异常单极纺锤体向双极纺锤体的转变来抑制 HSET 运动活动。Solidagonic acid 抑制裂殖酵母细胞死亡,并使有丝分裂纺锤体从单极形态逆转为双极形态。Solidagonic acid 对 Lactuca sativaL. 和 Lolium multiflorumLam 的幼苗具有生长抑制活性。 | |||
T5141 |
L-2-Phosphoglyceric acid disodium salt hydrate
L-2-Phosphoglyceric acid 二钠盐水合物 |
Others | Others |
L-2-Phosphoglyceric acid disodium salt hydrate 是一种甘油酸,可作为糖酵解第九步的底物。它被烯醇化酶催化为磷酸烯醇式丙酮酸 (PEP),这是葡萄糖转化为丙酮酸的倒数第二个步骤。 | |||
T37452 |
Stephacidin B
|
Others | Others |
Stephacidin B is a fungal metabolite that has been found inA. ochraceus.1Dimeric stephacidin B is rapidly converted to a monomer, avrainvillamide ,in vitro.2Stephacidin B is cytotoxic to a variety of cancer cells, including testosterone-independent PC3 and -sensitive LNCaP prostate cancer cells (IC50s = 0.37 and 0.06 μM, respectively) and estradiol-independent SK-BR-3 and -sensitive MCF-7 breast cancer cells (IC50s = 0.32 and 0.27 μM, respectively).1It induces apoptosis in HepG2 and Huh7 hepatoc... |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-01108 |
Factor VII Protein, Human, Recombinant (His & SUMO)
F7,Serum prothrombin conversion accelerator,Proconv... |
Human | E. coli |
Factor VII Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPY-02014 |
Coagulation factor VII/F7 Protein, Human, Recombinant (His)
coagulation factor VII (serum prothrombin conversion |
Human | HEK293 Cells |
Coagulation factor VII, also known as Serum prothrombin conversion accelerator, Factor VII, F7 and FVII, is a member of the peptidase S1 family. Factor VII is one of the central proteins in the coagulation cascade. It is an enzyme of the serine protease class, and Factor VII (FVII) deficiency is the most frequent among rare congenital bleeding disorders. Factor VII contains two EGF-like domains, one Gla (gamma-carboxy-glutamate) domain and one peptidase S1 domain. The main role of factor VII is ... | |||
TMPH-01225 |
DHODH Protein, Human, Recombinant (His)
DHOdehase,DHODH,Dihydroorotate oxidase,Dihydroorotate dehydr... |
Human | E. coli |
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | |||
TMPH-00857 |
ABAT Protein, Human, Recombinant (His & Myc & SUMO)
L-AIBAT,GABA aminotransferase,GABA transaminase,GABA-T,(S)-3... |
Human | E. coli |
Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine. ABAT Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 73.3 kDa and the accession number is P80404. | |||
TMPH-00007 |
HMGCR Protein, Human, Recombinant (His)
HMGCR,3-hydroxy-3-methylglutaryl-coenzyme A reductase |
Human | E. coli |
Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis. HMGCR is the main target of statins, a class of cholesterol-lowering drugs. | |||
TMPY-02483 |
ATP citrate lyase/ACLY Protein, Human, Recombinant (His)
ATPCL,ACL,ATP citrate lyase,CLATP |
Human | Baculovirus Insect Cells |
ATP citrate lyase, also known as Acly or Acl, is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is composed of two polymer chains which are polypeptides in human. ATP citrate lyase is responsible for catalyzing the conversion of citrate and CoA into acetyl-CoA and oxaloacetate, along with the hydrolysis of ATP. A definitive role for ATP citrate lyase in tumorigenesis has emerged from ATP citrate lyase RNAi and chemical inhibitor studies, show... | |||
TMPY-00203 |
LOXL2 Protein, Mouse, Recombinant (His)
1110004B06Rik,4930526G11Rik,9430067E15Rik,lysyl oxidase-like... |
Mouse | HEK293 Cells |
Lysyl oxidase homolog 2, also known as Lysyl oxidase-like protein 2, Lysyl oxidase-related protein 2, Lysyl oxidase-related protein WS9-14 and LOXL2, is a secreted protein that belongs to the lysyl oxidase family. LOXL2 contains four SRCR domains. The lysyl oxidase family is made up of five members: lysyl oxidase (LOX) and lysyl oxidase-like 1-4 ( LOXL1, LOXL2, LOXL3, LOXL4 ). All members share conserved C-terminal catalytic domains that provide for lysyl oxidase or lysyl oxidase-like enzyme act... | |||
TMPY-01104 |
Coagulation factor XI/F11 Protein, Human, Recombinant (His)
coagulation factor 11,coagulation factor XI,FXI |
Human | HEK293 Cells |
Factor XI (plasma thromboplastin antecedent) is a plasma glycoprotein, and a zymogen acting as a serine protease which participates in blood coagulation as a catalyst in the conversion of factor IX to factor IXa in the presence of calcium ions. It is an unusual dimeric protease, with structural features that distinguish it from vitamin K-dependent coagulation proteases. The factor XI is synthesized in the liver as a single polypeptide chain with a molecular weight estimated between 125 ~160 kDa ... | |||
TMPH-00693 |
L-lactate dehydrogenase Protein, E. coli O9:H4, Recombinant (His)
lldD,L-lactate dehydrogenase |
E. coli | E. coli |
Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain. | |||
TMPJ-00496 |
PGM2 Protein, Human, Recombinant (His)
Phosphopentomutase,Phosphodeoxyribomutase,Glucose phosphomut... |
Human | E. coli |
Phosphoglucomutase-2 (PGM2) is a member of PGM family, which catalyzes the inter-conversion of sugar phosphates and participates in anabolic and catabolic reactions. When cells are grown in glucose, PGM catalyzes the conversion of glucose-6-phosphate to glucose-1-phosphate an important precursor required for the synthesis of UDP glucose and trehalose. PGM2 catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphope... | |||
TMPH-02627 |
DHODH Protein, Mouse, Recombinant (E. coli, His)
Dihydroorotate oxidase,DHODH,Dihydroorotate dehydrogenase (q... |
Mouse | E. coli |
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | |||
TMPH-03278 |
DHODH Protein, Rat, Recombinant (His)
DHODH,DHOdehase,Dihydroorotate dehydrogenase (quinone), mito... |
Rat | E. coli |
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | |||
TMPH-01608 |
DCT Protein, Human, Recombinant (His & Myc & SUMO)
DT,TYRP2,Tyrosinase-related protein 2,L-dopachrome Delta-iso... |
Human | E. coli |
Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA). | |||
TMPH-02850 |
DHODH Protein, Mouse, Recombinant (His)
Dihydroorotate oxidase,Dihydroorotate dehydrogenase (quinone... |
Mouse | E. coli |
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. | |||
TMPH-00843 |
HSD11B1 Protein, Human, Recombinant (His & SUMO)
7-oxosteroid reductase,11-beta-hydroxysteroid dehydrogenase ... |
Human | E. coli |
Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol. HSD11B1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 45.5 kDa and the accession number is P28845. | |||
TMPH-00757 |
Reticuline oxidase Protein, Eschscholzia californica, Recombinant (His)
BBE1,Tetrahydroprotoberberine synthase,Berberine bridge-form... |
Eschscholzia californica | E. coli |
Essential to the formation of benzophenanthridine alkaloids in the response of plants to pathogenic attack. Catalyzes the stereospecific conversion of the N-methyl moiety of (S)-reticuline into the berberine bridge carbon of (S)-scoulerine. | |||
TMPH-02751 |
DCT Protein, Mouse, Recombinant (His & SUMO)
TRP2,L-dopachrome Delta-isomerase,TRP-2,TYRP2,L-dopachrome t... |
Mouse | E. coli |
Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA). DCT Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO tag. The predicted molecular weight is 69.7 kDa and the accession number is P29812. | |||
TMPH-00578 |
NrdD Protein, E. coli, Recombinant (His)
nrdD,Class III ribonucleoside-triphosphate reductase,Anaerob... |
E. coli | E. coli |
Catalyzes the conversion of ribonucleotides into deoxyribonucleotides, which are required for DNA synthesis and repair. NrdD Protein, E. coli, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 84.0 kDa and the accession number is P28903. | |||
TMPH-02626 |
DLAT Protein, Mouse, Recombinant (His)
Pyruvate dehydrogenase complex component E2,Dlat,Dihydrolipo... |
Mouse | HEK293 Cells |
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. | |||
TMPH-03654 |
Vaccinia virus (strain Western Reserve) 3-beta-HSD Protein (His & Myc)
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase,OP... |
VACV | E. coli |
Catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. During viral infection, steroid production contributes to virulence by inhibiting the host inflammatory response. Vaccinia virus (strain Western Reserve) 3-beta-HSD Protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted... | |||
TMPH-02299 |
UGP2 Protein, Human, Recombinant (His & SUMO)
UDP-glucose pyrophosphorylase,UTP--glucose-1-phosphate uridy... |
Human | E. coli |
UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. | |||
TMPH-02625 |
DLAT Protein, Mouse, Recombinant (E. coli, His)
Dihydrolipoyllysine-residue acetyltransferase component of p... |
Mouse | E. coli |
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. DLAT Protein, Mouse, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 62.8 kDa and the accession number is Q8BMF4. | |||
TMPH-00074 |
GlcNAcT-I Protein, Arabidopsis thaliana, Recombinant (His)
N-acetylglucosaminyltransferase I,Protein COMPLEX GLYCAN LES... |
Arabidopsis thaliana | Baculovirus Insect Cells |
Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans. Required for normal root growth and morphology. GlcNAcT-I Protein, Arabidopsis thaliana, Recombinant (His) is expressed in Baculovirus insect cells with C-6xHis tag. The predicted molecular weight is 51.6 kDa and the accession number is Q9XGM8. | |||
TMPH-00404 |
Acetoacetate decarboxylase Protein, Clostridium acetobutylicum, Recombinant (His)
AADase,EC:4.1.1.4,ADC,AAD |
Clostridium acetobutylicum | Baculovirus Insect Cells |
Catalyzes the conversion of acetoacetate to acetone and carbon dioxide. Acetoacetate decarboxylase Protein, Clostridium acetobutylicum, Recombinant (His) is expressed in Baculovirus insect cells with C-6xHis tag. The predicted molecular weight is 33.2 kDa and the accession number is P23670. | |||
TMPH-02643 |
Enteropeptidase Protein, Mouse, Recombinant (His & Myc)
Serine protease 7,Prss7,Transmembrane protease serine 15,Ent... |
Mouse | HEK293 Cells |
Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases. | |||
TMPH-01862 |
PFAS Protein, Human, Recombinant (His & Myc & SUMO)
Phosphoribosylformylglycinamidine synthase,Formylglycinamide... |
Human | E. coli |
Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. PFAS Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 45.4 kDa and the accession number is O15067. | |||
TMPH-00167 |
L-arabinose isomerase Protein, Bacillus subtilis, Recombinant (His & Myc)
L-arabinose isomerase,araA |
Bacillus subtilis | E. coli |
Catalyzes the conversion of L-arabinose to L-ribulose. L-arabinose isomerase Protein, Bacillus subtilis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 63.6 kDa and the accession number is P94523. | |||
TMPH-01601 |
Lactoylglutathione lyase/GLO1 Protein, Human, Recombinant (GST)
Ketone-aldehyde mutase,Glyoxalase I,Lactoylglutathione lyase... |
Human | E. coli |
Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis. | |||
TMPH-00689 |
Propionate kinase Protein, E. coli O6:H1, Recombinant (His & Myc)
tdcD,Propionate kinase |
E. coli | E. coli |
Catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. Propionate kinase Protein, E. coli O6:H1, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 50.4 kDa and the accession number is P59244. | |||
TMPH-00575 |
GlpD Protein, E. coli, Recombinant (His)
glpD,Aerobic glycerol-3-phosphate dehydrogenase |
E. coli | E. coli |
Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses molecular oxygen or nitrate as electron acceptor. GlpD Protein, E. coli, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 60.8 kDa and the accession number is P13035. | |||
TMPH-00844 |
HSD11B2 Protein, Human, Recombinant (His)
HSD11B2,11-beta-hydroxysteroid dehydrogenase type 2,Short ch... |
Human | P. pastoris (Yeast) |
Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. HSD11B2 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 46.1 kDa and the accession number is P80365. | |||
TMPJ-00955 |
MDH1 Protein, Human, Recombinant (His)
Cytosolic Malate Dehydrogenase,MDH1,MDHA,Diiodophenylpyruvat... |
Human | E. coli |
Malate Dehydrogenase, Cytoplasmic (MDH1) is an enzyme which belongs to the MDH Type 2 sub-family of LDH/MDH superfamily. MDH1 is involved in the Citric Acid Cycle that catalyzes the conversion of Malate into Oxaloacetate (using NAD+) and vice versa. MDH1 should not be confused with Malic Enzyme, which catalyzes the conversion of Malate to Pyruvate, producing NADPH. MDH1 also participates in Gluconeogenesis, the synthesis of Glucose from smaller molecules. Pyruvate in the mitochondria is acted up... | |||
TMPH-03198 |
MGAT1 Protein, Rabbit, Recombinant (His & Myc)
MGAT1,Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosa... |
Rabbit | E. coli |
Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans. MGAT1 Protein, Rabbit, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 53.2 kDa and the accession number is P27115. | |||
TMPH-00667 |
OGDC-E2 Protein, E. coli O157:H7, Recombinant (His)
Dihydrolipoamide succinyltransferase component of 2-oxogluta... |
E. coli | E. coli |
E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). OGDC-E2 Protein, E. coli O157:H7, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 49.9 kDa and the accession number is P0AFG7. | |||
TMPH-03260 |
Carboxypeptidase A1 Protein, Rat, Recombinant (His & Myc)
Cpa1,Carboxypeptidase A1,Cpa |
Rat | E. coli |
Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. Catalyzes the conversion of leukotriene C4 to leukotriene F4 via the hydrolysis of an amide bond. Carboxypeptidase A1 Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 39.6 kDa and the accession number is P00731. | |||
TMPH-02644 |
Enteropeptidase Protein, Mouse, Recombinant (His & SUMO)
Tmprss15,Entk,Enterokinase,Serine protease 7,Prss7,Transmemb... |
Mouse | E. coli |
Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases. Enteropeptidase Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 43.0 kDa and the accession number is P97435. | |||
TMPH-02476 |
HMGCR Protein, Mouse, Recombinant (His)
Hmgcr,3-hydroxy-3-methylglutaryl-coenzyme A reductase |
Mouse | E. coli |
Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis. HMGCR Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 20.4 kDa and the accession number is Q01237. | |||
TMPJ-00479 |
KHK Protein, Human, Recombinant (His)
KHK,Hepatic fructokinase,Ketohexokinase |
Human | HEK293 Cells |
Ketohexokinase, also known as Hepatic fructokinase, is a member of the carbohydrate kinase PfkB family. It exits as a homodimer and most abundant in liver, kidney, gut, spleen and pancreas. Low levels also found in adrenal, muscle, brain and eye.This enzyme catalyzes conversion of fructose to fructose-1-phosphate. It is the first enzyme with a specialized pathway that catabolizes dietary fructose. Defects in KHK are the cause of fructosuria. | |||
TMPH-02246 |
TGS1 Protein, Human, Recombinant (His & SUMO)
CLL-associated antigen KW-2,Cap-specific guanine-N2 methyltr... |
Human | E. coli |
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. | |||
TMPJ-00690 |
PGDS Protein, Human, Recombinant
Glutathione-Requiring Prostaglandin D Synthase,PGDS,Glutathi... |
Human | E. coli |
Hematopoietic Prostaglandin D Synthase (HPGDS) belongs to the GST superfamily and Sigma family. HPGDS contains one GST C-terminal domain and one GST N-terminal domain. HPGDS is highly expressed in adipose tissue, macrophages, and placenta, and it exists in the form of homodimer in living body. HPGDS is a cytosolic enzyme that isomerizes PGH(2). HPGDS is a bifunctional enzyme that catalyzes both the conversion of PGH2 to PGD2 and also shows low glutathione-peroxidase activity towards cumenehydrop... | |||
TMPY-04767 |
PMVK Protein, Human, Recombinant (His)
PMK,PMKA,phosphomevalonate kinase,HUMPMKI,PMKASE |
Human | E. coli |
PMVK is a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Studies in rat show that the message level and the enzyme activity of PMVK is regulated by sterol, and that this regulation is coordinated with 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol biosynthesis. | |||
TMPJ-01092 |
MGAT2 Protein, Human, Recombinant (His)
Alpha-1,Mannoside Acetylglucosaminyltransferase 2,6-Mannosyl... |
Human | HEK293 Cells |
Mannoside Acetylglucosaminyltransferase 2 (MGAT2) is a single-pass type II membrane protein that contains the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a hydrophobic non-cleavable signal-anchor domain and a C-terminal catalytic domain. MGAT2 catalyzes an essential step in the conversion of oligo-mannose to complex N-glycans. Defects in MGAT2 are the cause of congenital disorder of glycosylation type 2A. | |||
TMPY-03617 |
GMPR Protein, Human, Recombinant (His)
GMPR1,guanosine monophosphate reductase |
Human | E. coli |
GMPR, also known as GMPR1, belongs to the IMPDH/GMPR family.This familyofenzymesincludesIMP dehydrogenaseandGMP reductase. These enzymes are involved inpurine metabolism and adopt aTIM barrelstructure. GMPR is an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP. GMPR functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | |||
TMPH-02908 |
AICDA Protein, Mouse, Recombinant (His & Myc)
Single-stranded DNA cytosine deaminase,Cytidine aminohydrola... |
Mouse | E. coli |
Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. | |||
TMPJ-01368 |
GPC1 Protein, Mouse, Recombinant (His)
Gpc1,Glypican-1 |
Mouse | HEK293 Cells |
Glypican-1 is a cell membrane protein and belongs to the glypican family. The protein may act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. It is required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated sig... | |||
TMPJ-00989 |
MTHFS Protein, Human, Recombinant (His)
5-formyltetrahydrofolate cyclo-ligase,10-methenyl-tetrahydro... |
Human | E. coli |
5-formyltetrahydrofolate cyclo-ligase (MTHFS) belongs to the 5-formyltetrahydrofolate cyclo-ligase family. It is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, contributes to tetrahydrofolate metabolism. MTHFS helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. An increased activity of the encoded protein can result in an increas... | |||
TMPJ-00724 |
LDHA Protein, Human, Recombinant (His)
LDH-M,Renal Carcinoma Antigen NY-REN-59,Cell Proliferation-I... |
Human | E. coli |
L-Lactate Dehydrogenase A Chain (LDHA) is an enzyme that catalyzes the conversion of L-lactate and NAD+ to pyruvate and NADH in the final step of anaerobic glycolysis. LDHA contains an N-terminal coenzyme binding region, a central catalytic site, and at least nine utilized Lys acetylation and two Tyr phosphorylation sites. LDHA belongs to the lactate dehydrogenase family, expressed predominantly in muscle tissue. LDHA mutations have been linked to exertional myoglobinuria. | |||
TMPY-04762 |
CKM Protein, Human, Recombinant (His)
creatine kinase, muscle,M-CK,CKMM |
Human | E. coli |
CKM, also known as CK-MM, is mainly expressed in skeletal muscle. As the primary CK isoenzyme, it also can be detected in heart muscle. CKM is a subunit of creatine kinase (CK). CK is an enzyme expressed by various tissues and cell types. It catalyses the conversion of creatine and consumes adenosine triphosphate (ATP) to create phosphocreatine and adenosine diphosphate (ADP). In the cells, the cytosolic CK enzymes consist of two subunits, which can be either B (brain type) or M (muscle type). | |||
TMPJ-00788 |
UROD Protein, Human, Recombinant (His)
UPD,UROD,Uroporphyrinogen Decarboxylase,URO-D |
Human | E. coli |
Uroporphyrinogen decarboxylase (UROD), is an enzyme of the heme biosynthetic pathway which belongs to the uroporphyrinogen decarboxylase family. This enzyme is responsible for catalyzing the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. UROD is a homodimeric enzyme that catalyzes the fifth step in heme biosynthesis: the elimination of carboxyl groups from the four acetate side chains of uroporphyrinogen III to yield coproporphyrinogen... | |||
TMPH-01391 |
GPI Protein, Human, Recombinant (His)
Sperm antigen 36,Neuroleukin,Glucose-6-phosphate isomerase,G... |
Human | E. coli |
In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis. Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion. GPI Protein, Huma... | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
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TMIJ-0127 |
Diclofenac-d4
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Diclofenac-d4 是 Diclofenac 的氘代化合物。Diclofenac 的 CAS 号为 15307-86-5。Diclofenac 是一种具有抗炎活性的非甾体苯乙酸衍生物,是COX抑制剂,在 CHO 细胞中,对人 COX-1 和 COX-2 的IC50值分别为 4 和 1.3 nM。它对绵羊 COX-1 和 COX-2 的IC50值分别为 5.1 μM,0.84 μM。它通过活化 caspase 级联反应来诱导神经干细胞凋亡。 | |||
TMIJ-0519 |
Fosaprepitant-d4 Dimeglumine
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Fosaprepitant-d4 Dimeglumine 是 Fosaprepitant Dimeglumine 的氘代化合物。Fosaprepitant Dimeglumine 的 CAS 号为 265121-04-8。Fosaprepitant dimeglumine 是 Aprepitant 的前药。它是一种神经激肽 1 受体拮抗剂,可用于预防化疗引起的恶心呕吐。 | |||
TMID-0178 |
Stearic acid-18,18,18-d3
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Stearic acid-18,18,18-d3 是 Stearic acid 的氘代化合物。Stearic acid 的 CAS 号为 57-11-4。Stearic acid是长链饱和脂肪酸,存在于许多动植物油脂中。 | |||
TMID-0233 |
Salbutamol-d9
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Salbutamol-d9 是 Salbutamol 的氘代化合物。Salbutamol 的 CAS 号为 18559-94-9。Salbutamol 是短效的 β2 肾上腺素受体激动剂,用于哮喘和慢性阻塞性肺疾病 (COPD) 引发的支气管痉挛的研究。 | |||
TMIH-0512 |
Salbutamol-d3
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Salbutamol-d3 是 Salbutamol 的氘代化合物。Salbutamol 的 CAS 号为 18559-94-9。Salbutamol 是短效的 β2 肾上腺素受体激动剂,用于哮喘和慢性阻塞性肺疾病 (COPD) 引发的支气管痉挛的研究。 |