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Search Results for " anemia "

Targets Recommended: Estrogen/progestogen Receptor

38

抑制剂 & 化合物

9

天然产物

2

化合物库

20

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name
L8400	血液病分子库		514 compounds
	514 种造血系统疾病相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；
L3100	造血毒性小分子库		101 compounds
	101 种生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；

化合物库

血液病分子库

Cat.No: L8400

Compounds: 514

造血毒性小分子库

Cat.No: L3100

Compounds: 101

Cat. No.	Product Name	Target	Signaling Pathways
T4505	Ferrous Bisglycinate Bisglycine iron(II) salt,Iron(II) bisglycinate,甘氨酸亚铁	Estrogen/progestogen Receptor	Endocrinology/Hormones
	Ferrous Bisglycinate (Bisglycine iron(II) salt) 是口服具有活力的铁强化剂剂补充剂。它可用于研究缺铁性贫血。
T8132	Iron sucrose Iron saccharate,蔗糖铁,Sucroferric oxyhydroxide	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Iron sucrose (Sucroferric oxyhydroxide) 是一种静脉注射铁制剂，也是一种促氧化剂，可用于研究缺铁性贫血。
T13692	Ferric maltol Iron(III) 2-methyl-4-oxo-4H-pyran-3-olate,麦芽酚铁	Others	Others
	Ferric maltol (Iron(III) 2-methyl-4-oxo-4H-pyran-3-olate) 是一种具有口服活性的单一铁离子 (Fe3+) 复合物，可用于研究炎症性肠病缺铁性贫血。
T7606	Guanosine 5'-diphosphate disodium salt 5'-二磷酸鸟苷二钠,5'-GDP-Na2,鸟苷-5'-二磷酸二钠盐	Endogenous Metabolite	Metabolism
	Guanosine 5'-diphosphate disodium salt (5'-GDP-Na2) 是一种核苷二磷酸。它是一种潜在的铁动员剂，能够阻断铁调素-铁转运蛋白相互作用，也可以调节白 IL-6/stat-3 途径。
T4651	Vadadustat N-(5-(3-氯苯基)-3-羟基吡啶-2-羰基)甘氨酸,PG-1016548,AKB-6548	HIF/HIF Prolyl-Hydroxylase; HIF	Angiogenesis; Chromatin/Epigenetic; Metabolism
	Vadadustat 是一种可滴定口服的缺氧诱导因子脯氨酰羟化酶 (HIF-PH) 抑制剂，是一种促红细胞生成剂，在动物慢性肾脏疾病模型中，有用于贫血的研究潜力。
T35044	Velaresol BW12C79,BW 12C,BW 12C79,BW-12C79,BW-12C	Others	Others
	Velaresol (BW 12C79) 可用于研究肿瘤、镰刀型贫血症和消化系统疾病。
T77595	H3B-8800	Others	Others
	H3B-8800是一种SF3B1调节剂，可用于研究输血依赖性贫血。
T77726	INCB-000928	ALK	Angiogenesis; Tyrosine Kinase/Adaptors
	Zilurgisertib (INCB-000928）是一种具有选择性和有效性的 ALK 2 抑制剂，用于研究癌症和 MF 贫血。
T61144	Hepcidin antagonist-1	Others	Others
	Hepcidin antagonist-1 是一种铁调素拮抗剂。Hepcidin antagonist-1 可用于研究像缺铁疾病和贫血类的代谢紊乱。
T40823	NCGC00029283	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	NCGC00029283 is a potent inhibitor of Werner syndrome helicase-nuclease (WRN), displaying inhibitory activity against WRN helicase with an IC 50 value of 2.3 μM. Additionally, it exhibits inhibitory effects on Bloom syndrome protein helicase (BLM) and Fanconi anemia group J protein helicase (FANCJ) with IC 50 values of 12.5 μM and 3.4 μM, respectively.
T15219	Enarodustat JTZ-951	Others; HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism; Others
	Enarodustat (JTZ-951) 是口服具有活力的 hypoxia-inducible factor prolyl hydroxylase 抑制剂，EC50=0.22 μM，有用于肾性贫血症的研究潜力。
T15422	GSK-626616	DYRK	Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors
	GSK-626616 是一种口服具有活力的 DYRK3抑制剂 (IC50:0.7 nM)。它以相似的效力抑制 DYRK 家族的其他成员，可用于研究贫血。
T13730	Hydroxocobalamin acetate	Others	Others
	Hydroxocobalamin acetate 是可注射的天然维生素 B12，其不良反应特征良好，可用于研究维生素 B12 缺乏症 (包括恶性贫血) 。
T1386	Phenazopyridine hydrochloride Urodine,Pyridium,Phenazopyridine HCl,盐酸非那吡啶	Sodium Channel	Membrane transporter/Ion channel
	Phenazopyridine hydrochloride (Pyridium) 是一种具有局部止痛作用的化学物质，常被用于缓解手术、损伤尿道及尿路感染引起的疼痛、刺激、不适和尿急。
T39520	Vamifeport VIT-2763	Ferroptosis	Apoptosis
	Vamifeport (VIT-2763) 是一种新型具有口服活性且靶向铁转运蛋白的抑制剂，可降低 SCD Townes 模型中的溶血标志物。VIT-2763 可改善贫血和红细胞生成，可改善血管炎症，可研究 β-地中海贫血。
T16478	PF-04447943 PF 04447943,Edelinontrine,PF04447943	PDE	Metabolism
	PF-04447943 (Edelinontrine) 是一种有效且具有选择性的的磷酸二酯酶 9A 抑制剂，IC50 为 12 nM，比作用于其他PDE家族成员选择性高 78 倍 (IC50>1000 nM)。PF-04447943 具有抗炎活性，通过抑制氧化应激、炎症和调节T细胞极化来减轻炎症反应，且可用于研究镰刀型贫血症。
T3528	Senicapoc 塞尼卡泊,ICA-17043	Potassium Channel	Membrane transporter/Ion channel
	Senicapoc (ICA-17043) 是有效的，选择性的Gardos 通道 (Ca2+激活的 K+通道;KCa3.1) 阻断剂，IC50为 11 nM。Senicapoc 阻断人红细胞的 Ca2+诱导的铷通量，IC50为 11 nM，抑制红细胞脱水的IC50为 30 nM。
T19846	Butafenacil	Others	Others
	Butafenacil is an effective anemia inducer.
T32193	Iron sorbitex Jectofer,Yectofer,Iron Sorbitol,HSDB 1967,Astra 1572	Others	Others
	Iron Sorbitex is used for the treatment of Iron Sorbitex deficiency anemia in patients with chronic kidney disease. Iron Sorbitex can be used as an Iron Sorbitex replacement product used for the treatment of Iron Sorbitex deficiency anemia in patients wit
T70823	Momelotinib HCl	Others	Others
	Momelotinib HCl is a JAK1/2 inhibitor, reducing anemia in myelofibrosis (MF) patients.
T31851	Formiminoglutamic acid NSC-334078,NSC334078,NSC 334078	Others	Others
	Formiminoglutamic acid is used to indicate folic acid deficiency and megaloblastic anemia of pregnancy with the measurement in the urine after oral administration of histidine.
T72817	Colibactin 742	Others	Others
	Colibactin 742 是一种稳定的大肠杆菌素衍生物，可诱导DNA 链间交联、激活 Fanconi Anemia DNA 修复途径和 G2/M 期阻滞。
T82454	Epoetin zeta	Others	Others
	Epoetin zeta，内源性促红细胞生成素(Erythropoietin)的衍生物，作为促红细胞生成剂使用。它主要应用于肾源性贫血及其相关研究领域。
T72184	Ac-Tyr-Val-Lys-Asp-aldehyde
	Ac-Tyr-Val-Lys-Asp-aldehyde，一种caspase-1抑制剂，适用于慢性疾病相关贫血、化疗诱导贫血及钻石黑扇贫血的研究。
T82455	Epoetin beta Genetical recombination,rhEPO,EPOCH	Others	Others
	Epoetin beta (rhEPO)为促红细胞生成素的重组形式，起着维持红细胞生成的作用，常用于贫血研究。
T25496	Hexaglutamate folate Pteglu6	Others	Others
	Hexaglutamate folate is a naturally occurring form of folic acid. The bioavailability of dietary folate may be limited by the need for the glutamate moieties to be deconjugated before absorption. Folate deficiency in humans results in anemia, neural tube
T39040	HIF-PHD-IN-1	Others	Others
	HIF-PHD-IN-1 is a pharmacological compound that acts as an orally active inhibitor of the hypoxia-inducible factor prolyl hydroxylase domain (HIF-PHD), displaying an IC50 of 54 nM for hHIF-PHD2. Its potential as a therapeutic agent for renal anemia is highly promising.
T18667	(S,R,S)-AHPC-C5-COOH VH032-C5-COOH	Others	Others
	(S,R,S)-AHPC-C5-COOH (VH032-C5-COOH) is a synthesized E3 ligase ligand-linker conjugate, contains the VH032 VHL-based ligand and a linker to form PROTACs. VH-032 is a selective and potent inhibitor of VHL/HIF-1α interaction with a Kd of 185 nM, has the potential for the study of anemia and ischemic diseases[1].
T16993	Taribavirin	Others	Others
	Taribavirin is an orally active inosine monophosphate dehydrogenase inhibitor. Taribavirin is designed to concentrate within the liver to target HCV-infected hepatocytes while minimizing distribution within red blood cells (RBCs) and the development of he
T79241	PHD2-IN-1	HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism
	PHD2-IN-1 为一种口服活性强效 HIF-脯氨酰羟化酶2 (PHD2) 抑制剂，具有 22.53 nM 的 IC50 值，适用于贫血病研究。
T16992	Taribavirin hydrochloride	Others	Others
	Taribavirin hydrochloride is an orally active inosine monophosphate dehydrogenase inhibitor. Taribavirin hydrochloride is designed to concentrate within the liver to target HCV-infected hepatocytes while minimizing distribution within red blood cells and
T75328	Hydroxocobalamin hydrochloride	Others	Others
	Hydroxocobalamin hydrochloride 是天然维生素B12的可注射形式，因其优良的安全性质，被用于研究维生素B12缺乏症（包括恶性贫血）相关治疗。
T74544	(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine	PROTACs	PROTAC
	(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine 是一种能同时靶向Smad3的泛素化和降解并提高HIF-α蛋白水平的双靶点PROTAC，展现出对肾性贫血的多途径抗纤维化和肾脏保护作用。
T77076	Luspatercept
	Luspatercept (ACE-536) 是一种重组修饰的 ActRIIB 融合蛋白，与转化生长因子β超家族配体结合，通过与GDF11结合抑制Smad2/3信号通路，从而增加红细胞数量并促进红细胞前体成熟，用于贫血的研究。
T72120	Guanosine 5'-diphosphate sodium GDP sodium	Others	Others
	Guanosine 5'-diphosphate (GDP) sodium 是一种核苷二磷酸，可激活 5'-三磷酸腺苷敏感的 K+通道。Guanosine 5'-diphosphate sodium 是一种潜在的铁动员剂，可阻断铁调素-铁转运蛋白 (hepcidin-ferroportin) 相互作用并调节 IL-6/stat-3通路。Guanosine 5'-diphosphate sodium 可用于炎症研究，如炎症性贫血 (AI)。
T76995	Sotatercept
	Sotatercept (ACE-011) 是一种可溶性激活素受体 2A (ACVR2A) 型 IgGFc 融合蛋白。Sotatercept 结合了激活素和生长分化因子，试图恢复生长促进和生长抑制信号通路之间的平衡。Sotatercept 在肺动脉高压、贫血、骨质流失、红细胞生成、多发性骨髓瘤 (MM) 溶骨性病变中有潜在的应用。
T82474	Empasiprubart ARGX-117
	Empasiprubart (ARGX-117) 是一种针对补体 C2 的人源化抑制性单克隆抗体。该抗体通过结合 C2 的 Sushi-2 结构域来阻止 C3 原转化酶的形成，进而抑制 C3 的激活，并阻断经典途径与凝集素途径的上游激活。Empasiprubart 展现出 pH 和钙依赖性的靶标结合能力，并在自身免疫性溶血性贫血以及抗体介导的器官移植排斥模型中，预防了补体介导的细胞毒性作用。
T84718	Folic acid disodium Vitamin B9 disodium,Vitamin M disodium	Others	Others
	Folic acid disodium，Folic acid的口服活性钠盐形式，具有固有溶出速率（IDR）为4.96·105g/s。它作为单碳转移反应中的辅助因子，有助于防治神经管缺陷、缺血和癌症。Folic acid disodium的过量可能会损害胚胎大脑发展并促进癌前细胞变化的增长；而其缺乏则可能导致巨幼细胞性贫血。

化合物

Ferrous Bisglycinate

Cat.No: T4505

Synonym: Bisglycine iron(II) salt,Iron(II) bisglycinate,甘氨酸亚铁

Target: Estrogen/progestogen Receptor

Cat.No: T8132

Synonym: Iron saccharate,蔗糖铁,Sucroferric oxyhydroxide

Target: Reactive Oxygen Species

Cat.No: T13692

Synonym: Iron(III) 2-methyl-4-oxo-4H-pyran-3-olate,麦芽酚铁

Target: Others

Guanosine 5'-diphosphate disodium salt

Cat.No: T7606

Synonym: 5'-二磷酸鸟苷二钠,5'-GDP-Na2,鸟苷-5'-二磷酸二钠盐

Target: Endogenous Metabolite

Cat.No: T4651

Synonym: N-(5-(3-氯苯基)-3-羟基吡啶-2-羰基)甘氨酸,PG-1016548,AKB-6548

Target: HIF/HIF Prolyl-Hydroxylase, HIF

Cat.No: T35044

Synonym: BW12C79,BW 12C,BW 12C79,BW-12C79,BW-12C

Target: Others

Cat.No: T77595

Target: Others

Cat.No: T77726

Target: ALK

Hepcidin antagonist-1

Cat.No: T61144

Target: Others

Cat.No: T40823

Target: DNA/RNA Synthesis

Cat.No: T15219

Synonym: JTZ-951

Target: Others, HIF/HIF Prolyl-Hydroxylase

Cat.No: T15422

Target: DYRK

Hydroxocobalamin acetate

Cat.No: T13730

Target: Others

Phenazopyridine hydrochloride

Cat.No: T1386

Synonym: Urodine,Pyridium,Phenazopyridine HCl,盐酸非那吡啶

Target: Sodium Channel

Cat.No: T39520

Synonym: VIT-2763

Target: Ferroptosis

Cat.No: T16478

Synonym: PF 04447943,Edelinontrine,PF04447943

Target: PDE

Cat.No: T3528

Synonym: 塞尼卡泊,ICA-17043

Target: Potassium Channel

Cat.No: T19846

Target: Others

Cat.No: T32193

Synonym: Jectofer,Yectofer,Iron Sorbitol,HSDB 1967,Astra 1572

Target: Others

Momelotinib HCl

Cat.No: T70823

Target: Others

Formiminoglutamic acid

Cat.No: T31851

Synonym: NSC-334078,NSC334078,NSC 334078

Target: Others

Cat.No: T72817

Target: Others

Cat.No: T82454

Target: Others

Ac-Tyr-Val-Lys-Asp-aldehyde

Cat.No: T72184

Cat.No: T82455

Synonym: Genetical recombination,rhEPO,EPOCH

Target: Others

Hexaglutamate folate

Cat.No: T25496

Synonym: Pteglu6

Target: Others

Cat.No: T39040

Target: Others

(S,R,S)-AHPC-C5-COOH

Cat.No: T18667

Synonym: VH032-C5-COOH

Target: Others

Cat.No: T16993

Target: Others

Cat.No: T79241

Target: HIF/HIF Prolyl-Hydroxylase

Taribavirin hydrochloride

Cat.No: T16992

Target: Others

Hydroxocobalamin hydrochloride

Cat.No: T75328

Target: Others

(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine

Cat.No: T74544

Target: PROTACs

Cat.No: T77076

Guanosine 5'-diphosphate sodium

Cat.No: T72120

Synonym: GDP sodium

Target: Others

Cat.No: T76995

Cat.No: T82474

Synonym: ARGX-117

Folic acid disodium

Cat.No: T84718

Synonym: Vitamin B9 disodium,Vitamin M disodium

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T7210	Guanosine 5'-diphosphate GDP,鸟苷-5ˊ-二磷酸	Endogenous Metabolite	Metabolism
	Guanosine 5'-diphosphate (GDP) 是核苷二磷酸，是潜在的铁动员剂，能够阻断铁调素-铁转运蛋白相互作用并调节白细胞介素-6 (IL-6)/stat-3 途径。
T1040	Vitamin B12 Cyanocobalamin,Cobalamin,维生素B12	Endogenous Metabolite	Metabolism
	Vitamin B12 (Cobalamin) 是一种维生素，在维持血流形成和脑、神经系统正常功能等方面发挥关键作用。
T8074	Esafosfan trisodium Fosfructose trisodium,D-果糖-1,6-二磷酸三钠盐,D-Fructose-1,6-diphosphate trisodium salt octahydrate,FDP trisodium,Diphosphofructose trisodium	Others; Endogenous Metabolite	Metabolism; Others
	Esafosfan trisodium (FDP trisodium) 是一种细胞保护性的天然糖磷酸盐，用于镰状细胞性贫血，心血管缺血和哮喘的研究。Fosfructose trisodium 通过刺激无氧糖酵解起作用，其在缺血条件下产生三磷酸腺苷。
T5543	TriacetonaMine 四甲基哌啶酮,Odoratine,tempidon,tmpone,Vincubine,2,2,6,6-Tetramethyl-4-piperidinone	Others	Others
	TriacetonaMine (Vincubine) 是一种合成医药产品、农药和聚合物光稳定剂的中间体。它是热解油的主要组分。它是植物和真菌提取物的人工制品，使用丙酮和氢氧化铵，或在分离过程的不同步骤中天然出现铵盐。
T3228	Fosfructose D-fructose-1,6-diphosphate,Betulanonaprenol,4937-84-2,Diphosphofructose,二磷酸果糖,Fructose 1,6-diphosphate,D-fructofuranose 1,6-bisphosphate,Esafosfan	Others; Endogenous Metabolite	Metabolism; Others
	D-fructose-1,6-diphosphate 是一种细胞保护性的天然糖磷酸盐，Fosfructose 通过刺激无氧糖酵解起作用，其在缺血条件下产生三磷酸腺苷,有潜力用于心血管缺血，镰状细胞性贫血和哮喘的研究。
T4723	D-Tagatose 塔格糖,D-(-)-Tagatose,D-塔格糖,d-tagatos	Others; Endogenous Metabolite	Metabolism; Others
	D-Tagatose (D-(-)-Tagatose) 是自然界中发现的一种罕见的单糖，具有益生元特性。它是研究II 型糖尿病的潜在抗糖尿病药物，也是帮助提升结肠有益细菌、预防结肠癌和抑制胆固醇的益生元。它是蔗糖的替代品，也是口香糖、果汁和饮料等食品中的低热量甜味剂。
T31836	Folate sodium Folic acid, monosodium salt,Folvite sodium
	Folate sodium, as a member of the vitamin B family, can stimulate the hematopoietic system. Folic acid can be used in the treatment and prevention of folate deficiencies and megaloblastic anemia.
T13731	Hydroxocobalamin monohydrochloride Vitamin B12a monohydrochloride,盐酸羟钴胺	Others	Others
	Hydroxocobalamin monohydrochloride is an injectable naturally occurring form of vitamin B12. It is used as a dietary supplement in the treatment of vitamin B12 deficiency including pernicious anemia.
T78476	Hydroxocobalamin Vitamin B12a	Endogenous Metabolite	Metabolism
	Hydroxocobalamin（Vitamin B12a）为可注射型天然维生素B12，不良反应特性良好，适用于治疗维生素B12缺乏症（包括恶性贫血）的膳食补充。

天然产物

Guanosine 5'-diphosphate

Cat.No: T7210

Synonym: GDP,鸟苷-5ˊ-二磷酸

Target: Endogenous Metabolite

Cat.No: T1040

Synonym: Cyanocobalamin,Cobalamin,维生素B12

Target: Endogenous Metabolite

Esafosfan trisodium

Cat.No: T8074

Synonym: Fosfructose trisodium,D-果糖-1,6-二磷酸三钠盐,D-Fructose-1,6-diphosphate trisodium salt octahydrate,FDP trisodium,Diphosphofructose trisodium

Target: Others, Endogenous Metabolite

Cat.No: T5543

Synonym: 四甲基哌啶酮,Odoratine,tempidon,tmpone,Vincubine,2,2,6,6-Tetramethyl-4-piperidinone

Target: Others

Cat.No: T3228

Synonym: D-fructose-1,6-diphosphate,Betulanonaprenol,4937-84-2,Diphosphofructose,二磷酸果糖,Fructose 1,6-diphosphate,D-fructofuranose 1,6-bisphosphate,Esafosfan

Target: Others, Endogenous Metabolite

Cat.No: T4723

Synonym: 塔格糖,D-(-)-Tagatose,D-塔格糖,d-tagatos

Target: Others, Endogenous Metabolite

Cat.No: T31836

Synonym: Folic acid, monosodium salt,Folvite sodium

Hydroxocobalamin monohydrochloride

Cat.No: T13731

Synonym: Vitamin B12a monohydrochloride,盐酸羟钴胺

Target: Others

Hydroxocobalamin

Cat.No: T78476

Synonym: Vitamin B12a

Target: Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01322	FANCC Protein, Human, Recombinant (His & SUMO) FANCC,Fanconi anemia group C protein	Human	E. coli
	DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. FANCC Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 79.4 kDa and the accession number is Q00597.
TMPY-02544	FANCA Protein, Human, Recombinant (His) FA-H,FA1,FAA,FAH,FANCH,FACA,Fanconi anemia, complem...	Human	Baculovirus Insect Cells
	FANCA is one of the six known Fanconi anemia gene products (FANCA, FANCC, FANCD2, FANCE, FANCF, and FANCG proteins). Fanconi anemia (FA) is a genetic disorder predisposing to aplastic anemia and cancer characterized by hypersensitivity to DNA-damaging agents and oxidative stress. FANCA associates with the IκB kinase (IKK) signalsome via interaction with IKK2. Components of the FANCA complex undergo rapid, stimulus-dependent changes in phosphorylation, which are blocked by kinase-inactive IKK2.
TMPH-00365	Chicken anemia virus (isolate USA 26p4) Apoptin Protein (His) VP3,Apoptin	CAV	E. coli
	May act as transcriptional regulator. Induces apoptosis in infected cells. Element of infectious replication cycle. Chicken anemia virus (isolate USA 26p4) Apoptin Protein (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 17.1 kDa and the accession number is P54095.
TMPH-00366	Chicken anemia virus (isolate Germany Cuxhaven-1) Apoptin Protein (GST) VP3,Apoptin	CAV	E. coli
	May act as transcriptional regulator. Induces apoptosis in infected cells. Element of infectious replication cycle. Chicken anemia virus (isolate Germany Cuxhaven-1) Apoptin Protein (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 40.3 kDa and the accession number is Q99152.
TMPH-00367	Chicken anemia virus (isolate Germany Cuxhaven-1) Apoptin Protein (His & SUMO) Apoptin,VP3	CAV	E. coli
	May act as transcriptional regulator. Induces apoptosis in infected cells. Element of infectious replication cycle. Chicken anemia virus (isolate Germany Cuxhaven-1) Apoptin Protein (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 29.3 kDa and the accession number is Q99152.
TMPH-02318	ZBTB32 Protein, Human, Recombinant (His) ZBTB32,Zinc finger and BTB domain-containing protein 32,FANC...	Human	E. coli
	DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells. ZBTB32 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 36.5 kDa and the accession number is Q9Y2Y4.
TMPJ-00947	RPS19 Protein, Human, Recombinant RPS19,40S Ribosomal Protein S19	Human	E. coli
	40S Ribosomal Protein S19 (RPS19) is a ribosomal protein that Belongs to the ribosomal protein S19e family. RPS19 is located in the nucleoli, and higher level expression is seen in colon carcinoma tissue than normal colon tissue. It required for pre-rRNA processing and maturation of 40S ribosomal subunits. RPS19 plays a role in many biological processes, such as endocrine pancreas development, erythrocyte differentiation, mRNA metabolic process. Defects in RPS19 are the cause of Diamond-Blackfan...
TMPK-01170	Hepcidin/HAMP Protein, Mouse, Recombinant (GST) Hamp1,LEAP-1,PLTR,HFE2B,LEAP1,Hepc1,Hepc	Mouse	E. coli
	Hepcidin, the main regulator of iron metabolism, is synthesized and released by hepatocytes in response to increased body iron concentration and inflammation. Deregulation of hepcidin expression is a common feature of genetic and acquired iron disorders: in Hereditary Hemochromatosis (HH) and iron-loading anemias low hepcidin causes iron overload, while in Iron Refractory Iron Deficiency Anemia (IRIDA) and anemia of inflammation (AI), high hepcidin levels induce iron-restricted erythropoiesis.
TMPJ-01034	TIM Protein, Human, Recombinant (His) TPI1,TPI,Triose-Phosphate Isomerase,Triosephosphate Isomeras...	Human	E. coli
	Triose-phosphate isomerase, also named Triose-phosphate isomerase, TPI and TIM, is an enzyme that catalyzes the reversible interconversion of the triose phosphate isomers dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate. TPI has been found in nearly every organism searched for the enzyme, including animals such as mammals and insects as well as in fungi, plants, and bacteria. However, some bacteria that do not perform glycolysis, like ureaplasmas, lack TPI. TPI plays an important role...
TMPY-04765	PKLR Protein, Human, Recombinant (His) PKRL,PKR,RPK,PKL,PK1,pyruvate kinase, liver and RBC	Human	E. coli
	Pyruvate kinase (PKLR) is a critical erythrocyte enzyme that is required for glycolysis and production of ATP. Pyruvate kinase deficiency (PKD) is the most frequent red blood cell enzyme abnormality of the glycolytic pathway and the most common cause of hereditary nonspherocytic hemolytic anemia. Over 250 PKLR-gene mutations have been described, including missense/nonsense, splicing and regulatory mutations, small insertions, small and gross deletions, causing PKD and hemolytic anemia of variabl...
TMPJ-01046	RPS7 Protein, Human, Recombinant (His) RPS7,40S ribosomal protein S7	Human	E. coli
	40S ribosomal protein S7(RPS7) belongs to the S7E family of ribosomal proteins. It is phosphorylated by NEK6 during post-translational modification. RPS7 is located in the cytoplasm, binds IPO9 with high affinity. it also can interacts with NEK6. As is required for rRNA maturation and typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. The unnormal expression of RPS7 may cause Diamond-Blackfan anemia 8.
TMPJ-00800	BPGM Protein, Human, Recombinant (His) 3-Diphosphoglycerate Mutase,2,DPGM,Bisphosphoglycerate Mutas...	Human	E. coli
	Bisphosphoglycerate Mutase (BPGM) is a member of the Phosphoglycerate Mutase family and BPG-Dependent PGAM subfamily. BPGM is a multifunctional enzyme. BPGM catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity. It also has phosphoglycerate phosphomutase activity. BPGM plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of 2,3-bisphosphoglycerate (2,3-BPG). Deficiency of BPGM increases the affinity of cells...
TMPY-04263	UBE2T Protein, Human, Recombinant (His) FANCT,PIG50,ubiquitin-conjugating enzyme E2T,HSPC150	Human	E. coli
	Ube2T is the E2 ubiquitin-conjugating enzyme of the Fanconi anemia DNA repair pathway and it is overexpressed in several cancers, representing an attractive target for the development of inhibitors. Notably, UBE2T locates at 1q32.1, and the gain of 1q is frequently observed in a variety of cancers. For instance, UBE2T serves an important role in the growth of bladder cancer cells, and may be considered as a potential biomarker and therapeutic target for bladder cancer.
TMPJ-00836	G6PD Protein, Human, Recombinant (His) Glucose-6-Phosphate 1-Dehydrogenase,G6PD	Human	HEK293 Cells
	Glucose-6-Phosphate 1-Dehydrogenase (G6PD) is a cytosolic enzyme that belongs to the glucose-6-phosphate dehydrogenase family. G6PD participates in the pentose phosphate pathway that supplies reducing energy to cells by maintaining the level of the co-enzyme nicotinamide adenine dinucleotide phosphate (NADPH). G6PD produces pentose sugars for nucleic acid synthesis and main producer of NADPH reducing power. NADPH in turn maintains the level of glutathione in these cells that helps protect the re...
TMPJ-00979	GSH-S Protein, Human, Recombinant (His) Glutathione Synthetase,GSS,GSH-S,GSH Synthetase,Glutathione ...	Human	E. coli
	Glutathione Synthetase belongs to the eukaryotic GSH synthase family. Glutathione Synthetase is the second enzyme in the glutathione biosynthesis pathway. It catalyses the condensation of gamma-glutamylcysteine and glycine to form glutathione. Glutathione play an important role in a variety of biological functions, including detoxification of xenobiotics, protection of cells from oxidative damage by free radicals, and membrane transport. The protein functions as a homodimer to catalyze the secon...
TMPY-04476	MVK Protein, Human, Recombinant (His & GST) POROK3,LRBP,MVLK,MK,mevalonate kinase	Human	Baculovirus Insect Cells
	Mevalonate kinase belongs to the GHMP kinase family, Mevalonate kinase subfamily. It can be found in a wide variety of organisms from bacteria to mammals. Mevalonate kinase may be a regulatory site in the cholesterol biosynthetic pathway. Defects in mevalonate kinase can cause mevalonic aciduria (MEVA). It is an accumulation of mevalonic acid which causes a variety of symptoms such as psychomotor retardation, dysmorphic features, cataracts, hepatosplenomegaly, lymphadenopathy, anemia, hypotonia,...
TMPY-02642	UBE2W Protein, Human, Recombinant (His) UBC16,UBC-16,ubiquitin-conjugating enzyme E2W (putative)	Human	E. coli
	Ubiquitin-conjugating enzymes, also known as UBE2W, E2 enzymes and more rarely as ubiquitin-carrier enzymes, perform the second step of protein ubiquitination. The modification of protein with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2W is a member of th...
TMPY-04380	DYRK3 Protein, Human, Recombinant (His & GST) REDK,RED,DYRK5,dual-specificity tyrosine-(Y)-phosphorylation...	Human	Baculovirus Insect Cells
	Dual specificity tyrosine-phosphorylation-regulated kinase 3, also known as Regulatory erythroid kinase, REDK and DYRK3, is a nucleus protein which belongs to theprotein kinase superfamily, CMGC Ser/Thr protein kinase family and MNB/DYRK subfamily. DYRKs are an emerging family of dual-specificity kinases that play key roles in cell proliferation, survival, and development. DYRK3 contains oneprotein kinase domain. Isoform 1 and isoform 2 of DYRK3 are highly expressed in testis and in hemat...
TMPH-01270	TRAIP Protein, Human, Recombinant (His) E3 ubiquitin-protein ligase TRAIP,TRAF-interacting protein,T...	Human	E. coli
	E3 ubiquitin ligase required to protect genome stability in response to replication stress. Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethered together, thereby blocking replication and transcription. Controls the choice between the two pathways of replication-coupled interstrand-cross-link repair by mediating ubiquitination of MCM7 subunit of the CMG helicase complex. Short ubiquitin chains on MCM7 promote recruitm...
TMPH-01267	RNF13 Protein, Human, Recombinant (His & Myc) RING finger protein 8,RNF8,E3 ubiquitin-protein ligase RNF8,...	Human	E. coli
	E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of hist...

重组蛋白

FANCC Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01322

Species: Human

Expression System: E. coli

FANCA Protein, Human, Recombinant (His)

Cat.No: TMPY-02544

Species: Human

Expression System: Baculovirus Insect Cells

Chicken anemia virus (isolate USA 26p4) Apoptin Protein (His)

Cat.No: TMPH-00365

Species: CAV

Expression System: E. coli

Chicken anemia virus (isolate Germany Cuxhaven-1) Apoptin Protein (GST)

Cat.No: TMPH-00366

Species: CAV

Expression System: E. coli

Chicken anemia virus (isolate Germany Cuxhaven-1) Apoptin Protein (His & SUMO)

Cat.No: TMPH-00367

Species: CAV

Expression System: E. coli

ZBTB32 Protein, Human, Recombinant (His)

Cat.No: TMPH-02318

Species: Human

Expression System: E. coli

RPS19 Protein, Human, Recombinant

Cat.No: TMPJ-00947

Species: Human

Expression System: E. coli

Hepcidin/HAMP Protein, Mouse, Recombinant (GST)

Cat.No: TMPK-01170

Species: Mouse

Expression System: E. coli

TIM Protein, Human, Recombinant (His)

Cat.No: TMPJ-01034

Species: Human

Expression System: E. coli

PKLR Protein, Human, Recombinant (His)

Cat.No: TMPY-04765

Species: Human

Expression System: E. coli

RPS7 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01046

Species: Human

Expression System: E. coli

BPGM Protein, Human, Recombinant (His)

Cat.No: TMPJ-00800

Species: Human

Expression System: E. coli

UBE2T Protein, Human, Recombinant (His)

Cat.No: TMPY-04263

Species: Human

Expression System: E. coli

G6PD Protein, Human, Recombinant (His)

Cat.No: TMPJ-00836

Species: Human

Expression System: HEK293 Cells

GSH-S Protein, Human, Recombinant (His)

Cat.No: TMPJ-00979

Species: Human

Expression System: E. coli

MVK Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04476

Species: Human

Expression System: Baculovirus Insect Cells

UBE2W Protein, Human, Recombinant (His)

Cat.No: TMPY-02642

Species: Human

Expression System: E. coli

DYRK3 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04380

Species: Human

Expression System: Baculovirus Insect Cells

TRAIP Protein, Human, Recombinant (His)

Cat.No: TMPH-01270

Species: Human

Expression System: E. coli

RNF13 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01267

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0591	Vadadustat-13C2-15N
	Vadadustat-13C2-15N 是 Vadadustat 的 13C 和 15N 的标记化合物。Vadadustat 的 CAS 号为 1000025-07-9。Vadadustat 是一种可滴定口服的缺氧诱导因子脯氨酰羟化酶 (HIF-PH) 抑制剂，是一种促红细胞生成剂，在动物慢性肾脏疾病模型中，有用于贫血的研究潜力。
T69966	Roxadustat-d5
	Roxadustat-d5 is intended for use as an internal standard for the quantification of roxadustat by GC- or LC-MS. Roxadustat is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH; IC50s = 1.4, 1.26, and 1.32 µM for HIF-PH1, HIF-PH2, and HIF-PH3, respectively). It is selective for HIF-PH over other 2-oxoglutarate-dependent dioxygenases, including lysine-specific demethylase 5A (KDM5A), KDM5B, -5C, -5D, and -6B (IC50s = >100 µM for all). Roxadustat (10-200 µM) stabilizes HIF-1α and ...

同位素标记化合物

Vadadustat-13C2-15N

Cat.No: TMIH-0591

Cat.No: T69966

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