26
16
3
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3061 |
Lorlatinib
劳拉替尼,PF-6463922,PF-06463922,Loratinib |
Apoptosis; Tyrosine Kinases; ROS; ALK; ROS Kinase | Angiogenesis; Apoptosis; Immunology/Inflammation; Tyrosine Kinase/Adaptors |
Lorlatinib (PF-6463922) 是一种具有口服活性,选择性,脑渗透性和 ATP 竞争性的ROS1/ALK 抑制剂,具有抗癌活性。它对 ROS1、野生型 ALK 和 ALKL1196M 的Ki 值分别为 <0.025 nM、<0.07 nM 和 0.7 nM。 | |||
T5426 |
DMNQ
|
Reactive Oxygen Species; ROS | Immunology/Inflammation; Metabolism; NF-κB |
DMNQ 是氧化还原循环剂,以浓度依赖性方式在细胞内产生超氧化物和过氧化氢,能够诱导ROS 增加。 | |||
T38404 |
MJ33 lithium salt
|
ROS | Immunology/Inflammation |
MJ33 lithium salt 是 NADPH 氧化酶 2 型介导的 ROS 生成抑制剂,是一种氟化磷脂类似物,可抑制过氧化物还蛋白 6 (Prdx6) 的磷脂酶 A2 (PLA2) 活性,可用于研究急性肺损伤。 | |||
T41340 |
Bifenthrin
|
Apoptosis | Apoptosis |
Bifenthrin 是一种合成拟除虫菊酯类杀虫剂。Bifenthrin 通过ROS生成、钙离子稳态破坏和MAPK信号级联改变诱导牛乳腺上皮细胞死亡。Bifenthrin 诱导细胞周期停滞,诱导细胞凋亡。 | |||
T17250 |
W-54011
|
ROS; Complement System | Immunology/Inflammation |
W-54011 是口服有效的非肽 C5a 受体拮抗剂,抑制125I 标记的 C5a 与人嗜中性白细胞的结合,Ki 为 2.2 nM。它还抑制C5a 诱导的人嗜中性粒细胞的细胞内 Ca2+动员,趋化性和ROS 的生成,IC50分别为 3.1 nM、2.7 nM 和1.6 nM。 | |||
T7709 |
(E/Z)-GSK5182
GSK5182(Z/E) |
Estrogen/progestogen Receptor; ROS | Endocrinology/Hormones; Immunology/Inflammation |
(E/Z)-GSK5182 (GSK5182(Z/E)) 是 (E)-GSK5182 和 (Z)-GSK5182 的外消旋体。GSK5182 是一种具有高效选择性和口服活性的ERRγ的反向激动剂,其IC50值为 79 nM。GSK5182 还诱导肝癌细胞中活性氧 (ROS)的产生。 | |||
TD0102 |
1,3-Diphenylisobenzofuran
DPBF |
Others | Others |
1,3-Diphenylisobenzofuran (DPBF) 是一种荧光探针,对单线态氧(1O2) 的具有高特异性,可形成内过氧化物并分解成 1,2-dibenzoylbenzene,可用于活性氧生成的检测。 | |||
T35976 |
6-Formylpterin
Pterin-6-aldehyde,6 Formylpterin |
Apoptosis; NOS; Xanthine Oxidase; Antibacterial | Apoptosis; Immunology/Inflammation; Metabolism; Microbiology/Virology |
6-Formylpterin (Pterin-6-aldehyde) 是 Xanthine Oxidase 的抑制剂(Ki约为0.6 nM),对沙鼠的短暂性IRI具有强大的神经保护作用。6-Formylpterin 诱导 HL-60 细胞内ROS 生成以及细胞凋亡 (apoptosis)。6-Formylpterin 抑制iNOS的表达,可在细胞内产生过氧化氢并恢复人中性粒细胞杀菌活性受损。 | |||
T3647 |
HTHQ
HX 1171,HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone),1-O-hexyl-2,3,5-trimethylhydroquinone |
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
HTHQ (HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone)) 是一种强力的亲脂性酚类抗氧化剂。它通过与活性氧直接反应,清除 ROS,从而形成更稳定的自由基,具有很强的抗氧化活性。 | |||
T61186 |
Antitumor agent-57
|
Others | Others |
Antitumor agent-57 (Compound 3o) is a potent NQO1-directed antitumor compound. It effectively inhibits tumor cell growth, induces ROS generation, and promotes cell apoptosis [1]. | |||
T13727 |
Huangjiangsu A
|
Others | Others |
Huangjiangsu A has hepatoprotective potential against H2O2-induced cytotoxicity and ROS generation and could be promising as potential therapeutic agents for liver diseases. Huangjiangsu A is isolated from D. villosa. | |||
T61623 |
Ecabet
|
Others | Others |
Ecabet sodium (TA-2711) is a chemical compound utilized for the clinical treatment of gastrointestinal disease through the suppression of reactive oxygen species (ROS) generation and enhancement of Helicobacter pylori eradication [1]. Moreover, Ecabet sodium effectively attenuates apoptosis [2]. | |||
T78887 |
ROS-IN-2
|
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
ROS-IN-2 (compound 85) 为次狼烷三萜衍生物,具有抑制细胞内过量ROS及其他氧化应激源生成的作用,从而保护线粒体避免受损。该化合物在心肌缺血/再灌注(MI/R)损伤研究中具有潜在应用价值。 | |||
T79646 |
Anticancer agent 153
|
Apoptosis | Apoptosis |
Anticanceragent 153(Compound 3)通过诱导Reactive Oxygen Species的生成来引发apoptosis。该化合物导致MMP水平的降低,并有效抑制癌细胞增殖。 | |||
T63599 |
Anticancer agent 54
|
Others | Others |
Anticancer agent 54 是有效的抗癌剂,其抗癌活性取决于 DNA 嵌入和 ROS 生成。 Anticancer agent 54 能够将细胞周期阻滞在 G0/G1 期,并诱导细胞凋亡 (apoptosis),具有抗增殖效果。 | |||
T72121 |
Tetrahydroxyquinone monohydrate
Tetrahydroxybenzoquinone monohydrate,Tetrahydroxy-1,4-benzoquinone monohydrate,Tetrahydroxy-1,4-benzoquinone monohydrate ; Tetrahydroxybenzoquinone monohydrate |
Others | Others |
Tetrahydroxyquinone monohydrate (Tetrahydroxy-1,4-benzoquinone monohydrate),为一种抗白内障药物,属于具氧化还原活性的苯醌类化合物。此化合物能通过与半醌自由基共同参与氧化还原循环过程中,促进活性氧 (ROS) 的生成。 | |||
T78158 |
MitoCur-1
|
Others | Others |
MitoCur-1为一种姜黄素类似物,作为线粒体抗氧化硫氧还蛋白还原酶2(TrxR2)抑制剂,展现亲电性与线粒体靶向特性。该化合物能特异性诱导活性氧(ROS)生成,表现出抗肿瘤活性。 | |||
T61896 |
hCAIX-IN-12
|
Others | Others |
hCAIX-IN-12 是有效的hCAIX 抑制剂,抑制 CAIX 和 CAII 的IC50分别为 0.74 和 10.78 μM。hCAIX-IN-12 抗细胞增殖并诱导凋亡 (apoptosis)。hCAIX-IN-12 可以增加ROS 的产生。hCAIX-IN-12在结直肠癌(CRC)中具有研究潜力。 | |||
T79602 |
MTP
|
Autophagy | Autophagy |
MTP作为一种PKM2抑制剂,能够通过激活caspase-3来诱导癌细胞发生凋亡(apoptosis),同时诱导自噬(autophagy)过程并提高ROS的产生量。此外,MTP对JAK2信号传递通路也有抑制作用。该化合物主要用于研究口腔鳞状细胞癌。 | |||
T72631 |
TACC3 inhibitor 1
|
Others | Others |
TACC3 inhibitor 1为一种能透过血脑屏障的有效TACC3抑制剂,能诱导Apoptosis及使细胞周期在G2/M期停滞,同时促进细胞内ROS产生,表现出抗增殖与抗肿瘤活性。 | |||
T74225 |
ROS-ERS inducer 1
|
Others | Others |
ROS-ERS inducer 1 是一种基于4,5-二芳基咪唑的Pt(II)-N-杂环卡宾 (Pt(II)-NHC) 复合物,属于 II 型免疫原性细胞死亡(ICD)诱导剂。它能促使内质网应激(ERS)并伴随活性氧(ROS)的生成,进而在HCC细胞中触发损伤相关分子模式(DAMP)的释放。相比Cisplatin,ROS-ERS inducer 1 表现出更高的抗癌效能。 | |||
T64179 |
Anticancer agent 65
|
Others | Others |
Anticancer agent 65 在肿瘤细胞系中显示出良好的效果,尤其是 A549 细胞 (IC50: 1.07 μM)。Anticancer agent 65 能够将 A549 细胞的细胞周期阻滞在 S 期,诱导细胞凋亡,增加 p53、p21 的表达水平,并促使 ROS 生成和 MMP 崩溃。 | |||
T75537 |
N-Acetyldopamine dimer-2
|
Others | Others |
N-Acetyldopamine dimer-2(compound 2)是一种从蝉皮黄色粉末中分离出来的N-acetyldopamine二聚体,具有抗氧化和抗炎作用。它能抑制氧化低密度脂蛋白(LDL)的氧化、ROS的生成、NO的生成以及NF-κB的活性。 | |||
T72676 |
Tubulin/MMP-IN-1
|
Others | Others |
Tubulin/MMP-IN-1 是一种有效的tubulin 和MMP 抑制剂。Tubulin/MMP-IN-1具有研究癌症疾病的潜力。Tubulin/MMP-IN-1 抑制微管蛋白聚合,诱导细胞周期停滞在 G2/M 期,导致 HepG2 细胞产生反应性氧化应激 (ROS),并通过线粒体依赖性凋亡途径导致细胞凋亡[ 1]。 | |||
T79601 |
SPC-180002
|
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
SPC-180002是一种针对SIRT1/3的双重抑制剂,IC50值分别为1.13 μM和5.41 μM。该化合物可通过诱导ROS产生干扰氧化还原平衡,进而增强p21蛋白的稳定性并引起线粒体功能障碍,同时显著抑制细胞周期进程及癌细胞的增殖,并能激活Nrf2信号通路。 | |||
T74501 |
NHEJ inhibitor-1
|
Others | Others |
NHEJ inhibitor-1 (Compound C2) 是一种三功能 Pt(II) 复合物,可缓解非同源末端连接 (NHEJ)/同源重组 (HR) 相关的双链断裂 (DSB) 修复,从而避免非小细胞肺对顺铂的耐药性。NHEJ inhibitor-1 抑制损伤修复蛋白 Ku70 和 Rad51,从而使肿瘤对活性分子重新敏感。NHEJ inhibitor-1 还诱导 ROS 产生和MMP 降低。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3248 |
alpha-Boswellic acid
α-Boswellic acid,α-乳香酸 |
Others | Others |
alpha-Boswellic acid 是一种从乳香中提取得到的五环三萜类化合物,具有抗惊厥和抗癌作用。在动物体内,它是预防和减少阿尔茨海默病标志物,可用于阿尔茨海默病的研究。 | |||
T6S1930 |
Schisanhenol
五味子酚,Schizanhenol,Gomisin-K3 |
Antioxidant | oxidation-reduction |
Schisanhenol (Schizanhenol) 是一种UGT2B7的抑制剂,是一种天然化合物。 | |||
T3008 |
Lawsone methyl ether
2-Methoxy-1,4-naphthoquinone,2-Methoxy-p-naphthoquinone,2-Methoxynaphthoquinone,2-甲氧基-1,4-萘并醌 |
Apoptosis; Antibacterial; Antifungal | Apoptosis; Microbiology/Virology |
Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone) 是从凤仙花和Swertia calycina 中分离出的,有抗真菌和抗菌活性。 | |||
T5S2283 |
Sesamolin
|
p38 MAPK; Caspase; JNK | Apoptosis; MAPK; Proteases/Proteasome |
Sesaminol 是从Justicia orbiculata 中分离得到的一种天然产物,抑制脂质过氧化,具有神经保护作用和抗氧化活性。它通过抑制JNK、p38 MAPKs 和caspase-3磷酸化,抑制MAPK 的级联反应。 | |||
T6S0735 |
Flavokawain B
黄卡瓦胡椒素B,Flavokavain B,Flavokawin B,2'-Hydroxy-4',6'-Dimethoxychalcone |
Apoptosis; Others | Apoptosis; Others |
Flavokawain B (Flavokavain B) 是从卡瓦醉椒的根提取物中,分离出的查尔酮。它是一种凋亡诱导剂,可抑制各种癌细胞株生长。它以极低的无毒浓度抑制人脑内皮细胞的迁移和血管形成,具有抗血管生成活性。 | |||
T4S0797 |
Berberine
小檗碱,Berberin,Umbellatine,黄连素 |
Reactive Oxygen Species; Topoisomerase; Endogenous Metabolite; Antibacterial; Antibiotic; Autophagy | Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB |
Berberine (Umbellatine) 属于生物碱类天然产物,可以激活 AMPK、抑制 DNA 拓扑异构酶、诱导 ROS 生成。Berberine 具有抗肿瘤、抗菌、降血糖、降血脂等生物学活性。 | |||
T10554 |
Bixin
|
Others | Others |
Bixin is isolated from the seeds of Bixa orellana and possesses anti-tumor, anti-inflammatory, and antioxidant activities. Bixin treatment ameliorated cardiac dysfunction through inhibiting fibrosis, inflammation, and ROS generation. | |||
TN4785 |
Picrasidine I
|
NF-κB; ROS; MAPK | Immunology/Inflammation; MAPK; NF-κB |
Picrasidine I has antiosteoclastogenic effect by inhibiting inflammation induced activation of MAPKs, NF-κB and ROS generation followed by suppressing the gene expression of c-Fos and NFATc1 in osteoclast precursors. | |||
TN2039 |
Panaxydol
|
cAMP; p38 MAPK; JNK | GPCR/G Protein; MAPK |
Panaxydol has anti-cancer activity, can inhibit the growth and apoptosis of cancer cells, the signaling mechanisms involve a [Ca(2+)](i) increase, JNK and p38 MAPK activation, cAMP, MAP kinase and ROS generation through NADPH oxidase and mitochondria. | |||
T14545 |
Berberine chloride hydrate
Natural Yellow 18 chloride hydrate |
Reactive Oxygen Species; Topoisomerase; Endogenous Metabolite; Antibacterial; Antibiotic; Parasite; Autophagy | Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB |
Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) 是一种常用作抗生素的生物碱。Berberine chloride hydrate 具有抗肿瘤活性,诱导活性氧 (ROS) 生成并抑制 DNA 拓扑异构酶 (topoisomerase)。 | |||
T73201 |
Stigmane B
|
Others | Others |
Stigmane B 是一个核因子 E2 相关因子 (Nrf2) 激活剂。Stigmane B 抑制细胞凋亡 (apoptosis) 和活性氧 (ROS) 生成,提高抗氧化酶活性。Stigmane B 具有神经保护效果。 | |||
T79991 |
Condurango glycoside A
|
Others | Others |
Condurango glycoside A 作为p53激活剂,能够促进ROS的生成并且上调p53的表达。此外,Condurango glycoside A 还能够诱导HeLa细胞发生与DNA损伤相关的凋亡及过早老化。 | |||
TN3719 |
Cristacarpin
|
p38 MAPK; ROS; CDK; Antifection; p53 | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation; MAPK; Microbiology/Virology |
Cristacarpin exhibits moderate but selective activity towards DNA repair-deficient yeast mutants. It promotes endoplasmic reticulum (ER) stress, leading to sub-lethal reactive oxygen species (ROS) generation and which eventually terminates by triggering s | |||
TN2217 |
Sophoflavescenol
槐苦参醇,槐黄醇 |
Others; Beta-Secretase; BACE; PDE; AChR; AChE | Metabolism; Neuroscience; Others |
Sophoflavescenol 是异戊烯基黄酮类化合物,能够抑制PDE5的活性,IC50=0.013 μM。它也抑制 RLAR,HRAR,BACE1,AChE 和 BChE,IC50值分别为 0.30 µM,0.17 µM,10.98 µM,8.37 µM 和 8.21 µM。 | |||
TN3614 |
Cearoin
檀木 |
ERK; BCL; PARP; IκB/IKK; TNF; NF-κB; ROS; Caspase | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; NF-κB; Proteases/Proteasome |
Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing the expression of iNOS mRNA and LPS-induced mRNA expression of TNFα and CCL2. Cearoin induces aut | |||
TN4774 |
Physalin A
|
ERK; BCL; p38 MAPK; NF-κB; Androgen Receptor; ROS; JAK; JNK; STAT; p53; Autophagy | Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; Endocrinology/Hormones; Immunology/Inflammation; JAK/STAT signaling; MAPK; NF-κB; Stem Cells |
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate cancer cell growth through activation of cell apoptosis and downregulation of androgen receptor ex |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-02106 |
SH3PXD2A Protein, Human, Recombinant (His & Myc)
SH3PXD2A,SH3 multiple domains protein 1,SH3 and PX domain-co... |
Human | E. coli |
Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. | |||
TMPH-02264 |
RANKL/TNFSF11/CD254 Protein, Human, Recombinant (His)
Tumor necrosis factor ligand superfamily member 11,... |
Human | HEK293 Cells |
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multipl... | |||
TMPY-02391 |
SUMO1 Protein, Human, Recombinant (His)
small ubiquitin-like modifier 1,SMT3C,SMT3,SMT3H3,UBL1,SENP2... |
Human | E. coli |
Small ubiquitin-like modifier protein (SUMO) modification is a highly dynamic process, catalyzed by SUMO-specific activating (E1), conjugating (E2) and ligating (E3) enzymes, and reversed by a family of SUMO-specific proteases (SENPs). Small ubiquitin-like modifier 1 (SUMO1) is a member of the superfamily of ubiquitin-like proteins. Despite its structural similarity with ubiquitin, SUMO1 does not seem to play any role in protein degradation. SUMO1 plays an important role in modulation of NOX act... |