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Search Results for " phosphodiesterase 4 inhibitor "

Targets Recommended: Others

56

抑制剂 & 化合物

9

天然产物

31

重组蛋白

4

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T36018	Phosphodiesterase 4 Inhibitor	Others	Others
	Phosphodiesterase 4 (PDE4) inhibitor is an inhibitor of PDE4 with an IC50 value of 0.10 μM for the human recombinant enzyme.
T27172	Difamilast	PDE	Metabolism
	Difamilast 是局部的、选择性的非甾体磷酸二酯酶 4 抑制剂，对 B 亚型抑制作用较好 (IC50=11.2 nM)。它在研究轻度至中度特应性皮炎方面有研究的价值。
T7954	YM976	PDE	Metabolism
	YM976 是磷酸二酯酶 4 抑制剂(IC50:2.2 nM)。它能够抑制抗原诱导的气道反应，并有抗炎的作用。
T19706	Ro 20-1724 Ro-20-1724,4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone,Ro20-1724	PDE	Metabolism
	Ro 20-1724 (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) 是 cAMP 特异性磷酸二酯酶抑制剂 b>(PDE4/PDE IV)，其 Ki=1930 nM，具有神经保护作用。
T2923	Apremilast 阿普斯特,CC-10004,阿普司特	Apoptosis; TNF; PDE	Apoptosis; Metabolism
	Apremilast (CC-10004) 是一种口服有效的磷酸二酯酶 4 抑制剂，IC50为 74 nM。它抑制脂多糖释放TNF-α，IC50为 104 nM。
T16164	MY-5445 N-(3-chlorophenyl)-4-phenylphthalazin-1-amine	PDE	Metabolism
	MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) 是特异性的 cGMP 磷酸二酯酶 PDE5抑制剂，其 Ki=1.3 μM。它是一种 ABCG2转运蛋白调节剂，具有抗增殖活性。它能抑制人血小板凝集。
T33422	MK-0873 MK 0873,MK0873	PDE	Metabolism
	MK-0873 是一种新型且有效的选择性磷酸二酯酶 4 (PDE4) 抑制剂。
T4695	CP671305	PDE	Metabolism
	CP671305 是口服具有活力的 phosphodiesterase-4-D 选择性抑制剂，具有很高的活性。
T19865	GEBR-7b 3-环戊氧-4-甲氧基苯甲醛,3-(Cyclopentyloxy)-4-methoxybenzaldehyde	PDE	Metabolism
	GEBR-7b (3-(Cyclopentyloxy)-4-methoxybenzaldehyde) 是一种磷酸二酯酶 4 (PDE4) 抑制剂。
T3987	Lotamilast E6005,RVT-501	PDE	Metabolism
	Lotamilast (RVT-501) 是一种磷酸二酯酶4(PDE4) 选择性抑制剂，IC50=2.8 nM。
T4285	Crisaborole 克立硼罗,AN-2728,PF-06930164	PDE	Metabolism
	Crisaborole (AN-2728) 是一种有效的 PDE4和 cytokine 释放抑制剂，能够抑制 PDE4(IC50=0.49 μM)。
T30232	AWD 12-281 GSK 842470,GSK-842470,AWD12-281,AWD-12-281,GW 842470	PDE	Metabolism
	AWD 12-281 是一种选择性磷酸二酯酶 4 (PDE4) 抑制剂，具有抗炎活性和支气管扩张活性，用于研究慢性阻塞性肺疾病（COPD）。
T6644	Rolipram SB 95952,ZK 62711,咯利普兰,(R,S)-Rolipram	HIV Protease; Antibacterial; PDE	Metabolism; Microbiology/Virology; Proteases/Proteasome
	Rolipram (SB 95952) 是一种磷酸二酯酶 PDE4的选择性抑制剂，抑制 PDE4A，PDE4B 和 PDE4D 的 IC50分别为 3 nM，130 nM 和 240 nM。
T27475	GSK356278 GSK-356278,GSK 356278	PDE	Metabolism
	GSK356278 是一种有效的特异性磷酸二酯酶 4 (PDE4) 抑制剂，对人 PDE4A、PDE4B 和 PDE4D 的 pIC50 分别为 8.6、8.8 和 8.7。 GSK356278 具有抗炎、抗焦虑和增强认知的作用。
T31792	Filaminast UNII-CDD69JC61J,Way-pda-641,WAY-PDA 641,CDD69JC61J	PDE	Metabolism
	Filaminast (UNII-CDD69JC61J) 是磷酸二酯酶4抑制剂(PDE4抑制剂)和罗利普兰的类似物，罗利普兰被用作抗哮喘药物。
T67815	uk-50001	PDE	Metabolism
	uk-50001是一种磷酸二酯酶(PDE4) 4抑制剂，可用于许多疾病，特别是炎症、过敏、呼吸系统疾病、失调和病症以及伤口。
T23256	RS-25344 hydrochloride	PDE	Metabolism
	RS 25344 hydrochloride 是 cAMP-磷酸二酯酶 4 的选择性抑制剂，在人淋巴细胞中的 IC50为 0.28 nM，对 PDE I、II、III 仅具有微弱的抑制作用，IC50分别为 >100 μM、160 μM、330 μM。它具有抗炎、增强记忆力和认知能力以及抗肿瘤活性。
T39341	FCPR03	PDE	Metabolism
	FCPR03 是一种特异性磷酸二酯酶 4 (PDE4) 抑制剂，对 PDE4B1、PDE4D7 和 PDE4 催化结构域的 IC50 分别为 31 nM、47 nM 和 60 nM。 FCPR03 具有神经保护、抗炎和抗抑郁样作用。
T9239	RS-25344	PDE	Metabolism
	RS-25344 是一种有效的选择性磷酸二酯酶 (PDE) 4 抑制剂。它在体外抑制嗜酸性粒细胞趋化性并增加精子的进行性运动。
T10201	PDE IV-IN-1	PDE	Metabolism
	PDE IV-IN-1 是一种有效的磷酸二酯酶4 (PDE4)抑制剂，具有抗炎活性，可用于治疗哮喘，慢性阻塞性肺病和其他炎症性疾病，是研究抑郁症的潜在化合物。
T63056	Dovramilast CC-11050	PDE	Metabolism
	Dovramilast (CC-11050) 是一种具有口服活性的磷酸二酯酶4(PDE4)抑制剂，，可以减少促炎介质和细胞因子的产生。Dovramilast 可用于研究结核分枝杆菌感染和红斑狼疮。
T38625	Tanimilast CHF-6001	PDE	Metabolism
	Tanimilast (CHF-6001) 是一种新型的高效选择性磷酸二酯酶 4 抑制剂，IC 50值为0.026 ± 0.006 nM。Tanimilast 具有强大的抗炎活性，适用于肺部局部用药。Tanimilast 用于研究阻塞性肺病。
T16379	Oglemilast GRC 3886	PDE	Metabolism
	Oglemilast (GRC 3886) 是一种具有口服活性磷酸二酯酶 4 (PDE4) 抑制剂，对 PDE4D3 的 IC50 为 0.5 nM。Oglemilast 在体外和体内抑制肺细胞浸润，包括嗜酸性粒细胞增多和嗜中性粒细胞减少。Oglemilast 具有应用于炎症性气道疾病的潜力。
T70793	Parogrelil Free Base NM-702 Free Base	Leukotriene Receptor; PDE	GPCR/G Protein; Metabolism
	Parogrelil Free Base (NM-702 Free Base) 是一种选择性磷酸二酯酶3抑制剂，具有支气管扩张和抗炎作用，抑制白三烯（LT）D（4）和组胺诱导的离体豚鼠气管条的收缩，可用于研究支气管哮喘。
T1024	Roflumilast 罗氟司特,B9302-107,BYK 20869,APTA 2217,BY 217	PDE; RSV	Metabolism; Microbiology/Virology
	Roflumilast (APTA 2217) 是一种口服的长效 4 型磷酸二酯酶抑制剂 (PDE4)，具有抗炎和潜在的抗肿瘤活性，作用于PDE4A1，PDEA4，PDEB1和PDEB2，IC50分别为 0.7，0.9，0.7 和 0.2 nM。
T24382	L-826141 L826141,L826,141,L 826141,L-826,141,L 826,141	Others	Others
	L-826141 is an inhibitor of phosphodiesterase 4.
T19824	Drotaverine Drotaverine Hydrochloride	Others	Others
	Drotaverine Hydrochloride is a selective inhibitor of phosphodiesterase 4.
T24772	SCH-351591 SCH351591,SCH 351591,D4396,D 4396,D-4396	Others	Others
	SCH-351591 is an orally active inhibitor of phosphodiesterase 4.
T69399	MK-0359 besylate	Others	Others
	MK-0359 besylate is a Phosphodiesterase-4 (PDE4) inhibitor.
T26132	RS 14203 RS-14203,RS14203	Others	Others
	RS 14203 is a selective type 4 phosphodiesterase (PDE4) inhibitor.
T21043	Apremilast, (+/-)- Apremilast (+/-)-,	Others	Others
	Apremilast, (+/-)-, is a small molecule inhibitor of phosphodiesterase 4 (PDE4) with oral activity. It is used to treat psoriatic arthritis.
T11810	L791943	Others	Others
	L791943 is a selective, potent) inhibitor of Phosphodiesterase-4 (PDE4,IC50 of 4.2 nM).
T27557	HT-0712 IPL455903,IPL-455903,IPL 455903,HT0712	Others	Others
	HT-0712是一种磷酸二酯酶4 （PDE4）抑制剂。
T62988	Mufemilast	Others	Others
	Mufemilast 是一种磷酸二酯酶 4(PDE4) 的抑制剂。
T70925	GS-5759	Others	Others
	GS-5759 is a bifunctional ß2-Adrenoceptor Agonist and Phosphodiesterase 4 Inhibitor for Chronic Obstructive Pulmonary Disease with a Unique Mode of Action.
T11483	GSK256066 Trifluoroacetate GSK 256066 Trifluoroacetate,GSK256066 (2,2,2-trifluoroacetic acid)	PDE	Metabolism
	GSK 256066 Trifluoroacetate is a selective and high-affinity phosphodiesterase 4 (PDE) inhibitor (IC50: 3.2 pM for PDE4B). It can be used for the treatment of chronic obstructive pulmonary disease.
T38944	Tetomilast OPC-6535,Tetomilast	Others	Others
	Tetomilast (OPC-6535) is a phosphodiesterase-4 (PDE4) inhibitor, potentially effective in treating inflammatory bowel disease (IBD) and chronic obstructive pulmonary disease (COPD).
T15766	Lirimilast BAY 19-8004	PDE	Metabolism
	Lirimilast is an effective, selective, and orally active phosphodiesterase-4 (PDE4) inhibitor (IC50: 49 nM). Lirimilast has potently anti-inflammatory properties. Lirimilast can be used for the treatment of asthma or chronic obstructive pulmonary disease.
T61208	PDE4-IN-11	Others	Others
	PDE4-IN-11 is a potent phosphodiesterase isoenzyme 4 (PDE4) inhibitor, exhibiting remarkable bronchodilatory and anti-inflammatory characteristics. It is specifically designed for studying obstructive or inflammatory airway diseases [1] [2] [3].
T40356	PDE4-IN-3 PDE4-IN-3	Others	Others
	PDE4-IN-3 is a newly developed oral compound that acts as a potent inhibitor of the enzyme phosphodiesterase 4 (PDE4), displaying a high affinity for inhibition with an IC50 value of 4.2 nM.
T69491	(E/Z)-Ensifentrine	Others	Others
	(E/Z)-Ensifentrine is a potent and selective PDE3/4 inhibitor. (E/Z)-Ensifentrine acts as a long-acting inhibitor of the phosphodiesterase enzymes PDE-3 and PDE-4, producing both bronchodilator and antiinflammatory effects. It is being developed by Verona Pharma as a potential treatment for asthma and hay fever, and is currently in clinical trials.
T62367	Enpp-1-IN-4	Others	Others
	Enpp-1-IN-4 是一种有效的外核苷酸焦磷酸酶-磷酸二酯酶 1 (enpp-1) 抑制剂。Enpp-1-IN-4 具有潜力进行癌症疾病的研究。
T79538	PDE4-IN-13	Others	Others
	PDE4-IN-13 is a phosphodiesterase 4 inhibitor with an IC50 value of 1.56 μM, exhibiting anti-inflammatory and antioxidative properties. It is utilized in the study of chronic obstructive pulmonary disease (COPD).
T71561	LEO-29102	Others	Others
	LEO-29102 is a potent, selective, and soft-drug phosphodiesterase 4 (PDE4) inhibitor, which may be potentially useful for treatment of dermatological diseases. LEO 29102 shows properties suitable for patient-friendly formulations giving efficient drug delivery to the skin. LEO-29102 has reached phase 2 and demonstrated clinically relevant efficacy in the treatment of atopic dermatitis.
T73240	PDE5-IN-4	Others	Others
	PDE5-IN-4为磷酸二酯酶5（PDE5）抑制剂，应用于急性心肌梗死及再灌注损伤、消化系统疾病、糖尿病相关损害及肝功能衰竭的研究。
T79624	PDE4-IN-14	Others	Others
	PDE4-IN-14 (化合物1)是PDE4抑制剂，适用于研究与PDE4关联的疾病（例如炎症性和免疫性疾病、癌症及代谢性疾病等）。
T36133	3,3'-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one)	Others	Others
	3,3'-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) is a non-nucleotide inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1; Ki = 50 μM).1,2 It also inhibits urease (IC50 = 84.53 μM for the Jack bean enzyme).3 \|1. Choudhary, M.I., Fatima, N., Khan, K.M., et al. New biscoumarin derivatives-cytotoxicity and enzyme inhibitory activities. Bioorg. Med. Chem. 14(23), 8066-8072 (2006).\|2. Onyedibe, K.I., Wang, M., and Sintim, H.O. ENPP1, an old enzyme with new functions, ...
T11168	EHNA hydrochloride	Others	Others
	EHNA hydrochloride play roles in mediating diverse pharmacological responses, including antiviral, antitumour and antiarrhythmic effects. EHNA hydrochloride is a potent and selective dual inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2)(IC50=4 μM) and adenosine deaminase (ADA). EHNA hydrochloride exerts a concentration inhibition of the cGMP-stimulated PDE II (cGs-PDE)(IC50:0.8 μM (human), 2 μM (porcine myocardium)), but has smaller inhibitory effect on the unstimulated PDE2 activity.
T60920	PDE4-IN-8	Others	Others
	PDE4-IN-8 (Example 5) 是磷酸二酯酶4(PDE4)的有效抑制剂。PDE4-IN-8 对 PDE4B2 的 IC50值为 0.93 nM。然而，PDE4-IN-8 对 IL13、IL4、IFNy 的抑制作用微弱，IC50值分别为 4.04 nM, 36.33 nM, 2394 nM。
T69262	ABE171	Others	Others
	ABE171, also known as NVP-ABE171, is a potent and novel phosphodiesterase 4 inhibitor with anti-inflammatory activities. NVP-ABE171 inhibited the activity of phosphodiesterase 4A, 4B, 4C, and 4D with respective IC(50) values of 602, 34, 1230, and 1.5 nM. In human cells, NVP-ABE171 inhibited the eosinophil and neutrophil oxidative burst, the release of cytokines by T cells, and the tumor necrosis factor-alpha release from monocytes, in the nanomolar range. NVP-ABE171 inhibited the airway neutrop...

化合物

Phosphodiesterase 4 Inhibitor

Cat.No: T36018

Target: Others

Cat.No: T27172

Target: PDE

Cat.No: T7954

Target: PDE

Cat.No: T19706

Synonym: Ro-20-1724,4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone,Ro20-1724

Target: PDE

Cat.No: T2923

Synonym: 阿普斯特,CC-10004,阿普司特

Target: Apoptosis, TNF, PDE

Cat.No: T16164

Synonym: N-(3-chlorophenyl)-4-phenylphthalazin-1-amine

Target: PDE

Cat.No: T33422

Synonym: MK 0873,MK0873

Target: PDE

Cat.No: T4695

Target: PDE

Cat.No: T19865

Synonym: 3-环戊氧-4-甲氧基苯甲醛,3-(Cyclopentyloxy)-4-methoxybenzaldehyde

Target: PDE

Cat.No: T3987

Synonym: E6005,RVT-501

Target: PDE

Cat.No: T4285

Synonym: 克立硼罗,AN-2728,PF-06930164

Target: PDE

Cat.No: T30232

Synonym: GSK 842470,GSK-842470,AWD12-281,AWD-12-281,GW 842470

Target: PDE

Cat.No: T6644

Synonym: SB 95952,ZK 62711,咯利普兰,(R,S)-Rolipram

Target: HIV Protease, Antibacterial, PDE

Cat.No: T27475

Synonym: GSK-356278,GSK 356278

Target: PDE

Cat.No: T31792

Synonym: UNII-CDD69JC61J,Way-pda-641,WAY-PDA 641,CDD69JC61J

Target: PDE

Cat.No: T67815

Target: PDE

RS-25344 hydrochloride

Cat.No: T23256

Target: PDE

Cat.No: T39341

Target: PDE

Cat.No: T9239

Target: PDE

Cat.No: T10201

Target: PDE

Cat.No: T63056

Synonym: CC-11050

Target: PDE

Cat.No: T38625

Synonym: CHF-6001

Target: PDE

Cat.No: T16379

Synonym: GRC 3886

Target: PDE

Parogrelil Free Base

Cat.No: T70793

Synonym: NM-702 Free Base

Target: Leukotriene Receptor, PDE

Cat.No: T1024

Synonym: 罗氟司特,B9302-107,BYK 20869,APTA 2217,BY 217

Target: PDE, RSV

Cat.No: T24382

Synonym: L826141,L826,141,L 826141,L-826,141,L 826,141

Target: Others

Cat.No: T19824

Synonym: Drotaverine Hydrochloride

Target: Others

Cat.No: T24772

Synonym: SCH351591,SCH 351591,D4396,D 4396,D-4396

Target: Others

MK-0359 besylate

Cat.No: T69399

Target: Others

Cat.No: T26132

Synonym: RS-14203,RS14203

Target: Others

Apremilast, (+/-)-

Cat.No: T21043

Synonym: Apremilast (+/-)-,

Target: Others

Cat.No: T11810

Target: Others

Cat.No: T27557

Synonym: IPL455903,IPL-455903,IPL 455903,HT0712

Target: Others

Cat.No: T62988

Target: Others

Cat.No: T70925

Target: Others

GSK256066 Trifluoroacetate

Cat.No: T11483

Synonym: GSK 256066 Trifluoroacetate,GSK256066 (2,2,2-trifluoroacetic acid)

Target: PDE

Cat.No: T38944

Synonym: OPC-6535,Tetomilast

Target: Others

Cat.No: T15766

Synonym: BAY 19-8004

Target: PDE

Cat.No: T61208

Target: Others

Cat.No: T40356

Synonym: PDE4-IN-3

Target: Others

(E/Z)-Ensifentrine

Cat.No: T69491

Target: Others

Cat.No: T62367

Target: Others

Cat.No: T79538

Target: Others

Cat.No: T71561

Target: Others

Cat.No: T73240

Target: Others

Cat.No: T79624

Target: Others

3,3'-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one)

Cat.No: T36133

Target: Others

EHNA hydrochloride

Cat.No: T11168

Target: Others

Cat.No: T60920

Target: Others

Cat.No: T69262

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN2159	Robustine 大叶桉亭,8-羟基白鲜碱,4-甲氧基呋喃并[2,3-B]喹啉-8-醇	PDE	Metabolism
	Robustine 是一种从 Dictamnus albus 获得的呋喃喹啉生物碱，在体外对人磷酸二酯酶 5 (hPDE5A) 具有抑制作用。
T4S0792	Pinoresinol 4-O-β-D-glucopyranoside (+)-pinor,(+)-pinoresinol-β-D-glucoside; (+)-pinor,(+)-pinoresinol-β-D-glucoside	Others; Antioxidant	Others; oxidation-reduction
	(+)-pinoresinol-β-D-glucoside; (+)-pinor 是连翘中主要的活性呋喃类木脂素。它显示出抗氧化、降血压和环磷酸腺苷 (cAMP) 磷酸二酯酶抑制活性。
T17199	Udenafil 3-(6,7-二氢-1-甲基-7-氧代-3-丙基-1H-吡唑并[4,3-D]嘧啶-5-基)-N-[2-(1-甲基-2-吡咯烷基)乙基]-4-丙氧基苯磺酰胺,乌地那非	PDE	Metabolism
	Udenafil 是一种选择性的，有效的，具有口服活性的 5 型磷酸二酯酶 (PDE5) 抑制剂。它能够抑制 cGMP 水解，可用于研究勃起功能障碍的。
T8787	Drotaverine hydrochloride	PDE	Metabolism
	Drotaverine hydrochloride 是磷酸二酯酶 4 (PDE4)的抑制剂，也是 L 型电压依赖钙通道(L-VDCC)的阻滞剂，可阻断3',5'-环腺苷单磷酸的降解。它在体内有抗痉挛效果，但无抗胆碱能的效果。
T28019	(-)-Mesembrine Mesembrin,Mesembrine,Mesembranone	Others	Others
	Mesembrine is a serotonin reuptake inhibitor and is also a weak inhibitor of the enzyme phosphodiesterase 4 (PDE4).
TN2974	3-O-Methylquercetin tetraacetate	IL Receptor; TNF; PDE	Apoptosis; Immunology/Inflammation; Metabolism
	Quercetin 3-O-methyl ether is a potent phosphodiesterase (PDE)3/4 inhibitor, it has potential for treating asthma against ovalbumin-induced airway hyperresponsiveness.
TN3537	Braylin	IL Receptor; TNF; NF-κB	Apoptosis; Immunology/Inflammation; NF-κB
	Braylin has anti-inflammatory, antinociceptive and immunomodulatory effects, which possibly act through the glucocorticoid receptor activation and by inhibition of the transcriptional activity of NF-ÎºB. Braylin is also a phosphodiesterase-4 inhibitor, it could represent an ideal prototype of glucocorticoid receptor ligand, able to induce synergic immunomodulatory effects.
T4700	1,3,5-Trihydroxy-4-prenylxanthone
	1,3,5-Trihydroxy-4-prenylxanthone is a relatively potent inhibitor of phosphodiesterase type 5 (PDE5), with an IC50 value of 3.0 μM; it shows in vitro inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with IC50 valu
T75486	Toddacoumalone	Others	Others
	Toddacoumalone 是一种天然PDE4 (磷酸二酯酶 4) 抑制剂，效力中等，活性分子特性不完善。具有研究银屑病等炎症性疾病潜力。

天然产物

Cat.No: TN2159

Synonym: 大叶桉亭,8-羟基白鲜碱,4-甲氧基呋喃并[2,3-B]喹啉-8-醇

Target: PDE

Pinoresinol 4-O-β-D-glucopyranoside

Cat.No: T4S0792

Synonym: (+)-pinor,(+)-pinoresinol-β-D-glucoside; (+)-pinor,(+)-pinoresinol-β-D-glucoside

Target: Others, Antioxidant

Cat.No: T17199

Synonym: 3-(6,7-二氢-1-甲基-7-氧代-3-丙基-1H-吡唑并[4,3-D]嘧啶-5-基)-N-[2-(1-甲基-2-吡咯烷基)乙基]-4-丙氧基苯磺酰胺,乌地那非

Target: PDE

Drotaverine hydrochloride

Cat.No: T8787

Target: PDE

Cat.No: T28019

Synonym: Mesembrin,Mesembrine,Mesembranone

Target: Others

3-O-Methylquercetin tetraacetate

Cat.No: TN2974

Target: IL Receptor, TNF, PDE

Cat.No: TN3537

Target: IL Receptor, TNF, NF-κB

1,3,5-Trihydroxy-4-prenylxanthone

Cat.No: T4700

Cat.No: T75486

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00749	FGF-2 Protein, Human, Recombinant fibroblast growth factor 2 (basic),FGF-2,FGFB,HBGF-2,BFGF	Human	E. coli
	FGF-2 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 16.5 kDa and the accession number is P09038-4.
TMPJ-00864	VEGF165 Protein, Human, Recombinant Vascular Endothelial Growth Factor Isoform 165,血管内皮生长因子,VEGF...	Human	HEK293 Cells
	Human Vascular endothelial growth factor (VEGF), also known as VEGF-A and vascular permeability factor (VPF), belongs to the platelet-derived growth factor family of cysteine-knot growth factors. It is a potent activator in vasculogenesis and angiogenesis both physiologically and pathologically. VEGF-A has 8 differently spliced isoforms, of which VEGF165 is the most abundant one. VEGF165 is a disulfide-linked homodimer consisting of two glycosylated 165 amino acid polypeptide chains. VEGF stimul...
TMPK-00823	VEGF165 Protein, Human, Recombinant (His & Avi) 血管内皮生长因子,RP1-261G23.1,MVCD1,MGC70609,VEGFA,VEGFMGC70609,VPF,...	Human	HEK293 Cells
	Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF165 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 22.2 kDa and the accession number is P15692-4.
TMPY-04911	VEGF165 Protein, Human, Recombinant (His & Avi), Biotinylated vascular endothelial growth factor A,血管内皮生长因子	Human,Cynomolgus	HEK293 Cells
	VEGF165 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 23.1 kDa and the accession number is P15692-4.
TMPY-02893	NT5C3A/NT5C3 Protein, Human, Recombinant P5N1,P5N-1,hUMP1,NT5C3,cN-III,PSN1,UMPH1,UMPH,POMP,5'-nucleo...	Human	E. coli
	NT5C3A (5'-Nucleotidase, Cytosolic IIIA) is a Protein Coding gene. This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded protein is the type 1 isozyme of pyrimidine 5' nucleotidase and catalyzes the dephosphorylation of pyrimidine 5' monophosphates. NT5C3A expression required both an intronic IFN-stimulated response element and the IFN-stimulated transcription factor IRF1. Overexpression of NT5C3A, but...
TMPK-00424	CD45 Protein, Human, Recombinant (His & Avi), Biotinylated LCA,LY5,EC 3.1.3.48,CD45,L-CA,T200,CD4...	Human	HEK293 Cells
	PTPRC (also known as CD45),T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) complex. CD45 ativates Lck by opposing the negative regulatory kinase Csk. Paradoxically, CD45 has also been implicated in suppressing TCR signaling by dephosphorylating the same signaling motifs within the TCR complex upon which Lck acts. CD45 Protein, Human, Recombinant (His & Avi...
TMPK-00822	VEGF165 Protein, Human, Recombinant (His & Avi), FITC-Labeled RP1-261G23.1,VEGFA,MGC70609,VEGF,VEGFMGC70609,VPF,VAS,MVCD1,...	Human	HEK293 Cells
	Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF165 Protein, Human, Recombinant (His & Avi), FITC-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 22.2 kDa and the accession number is P15692-4.
TMPY-05598	Siglec-2/CD22 Protein, Human, Recombinant (hFc & Avi), Biotinylated SIGLEC2,SIGLEC-2,CD22 molecule	Human	HEK293 Cells
	Siglec-2/CD22 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 103.7 kDa and the accession number is P20273-4.
TMPY-04471	APEG1 Protein, Human, Recombinant (His) SPEG complex locus,BPEG,SPEGalpha,SPEGβ,APEG-1,SPEGbeta,APEG...	Human	E. coli
	Striated muscle preferentially expressed protein kinase, also known as aortic preferentially expressed protein 1, APEG-1, SPEG and KIAA1297, is a protein that belongs to the protein kinase superfamily and CAMK Ser/Thr protein kinase family. SPEG / APEG-1 contains two fibronectin type-III domains, nine Ig-like (immunoglobulin-like) domains, two protein kinase domains. Isoform 1 of SPEG is preferentially expressed in striated muscle. Non-kinase form such as isoform 3 of SPEG is predominantly expre...
TMPJ-01333	TEM8/ANTXR1 Protein, Human, Recombinant (His) ATR,ANTXR1,TEM8,Tumor Endothelial Marker 8,Anthrax Toxin Rec...	Human	HEK293 Cells
	Anthrax Toxin Receptor 1 (ANTXR1) is a single-pass type I membrane protein that belongs to the ATR family. ANTXR1 contains one VWFA domain and binds PA through the VWA domain. ANTXR1 is highly expressed in tumor endothelial cells. ANTXR1 plays a role in cell attachment and migration. ANTXR1 interacts with extracellular matrix proteins and the actin cytoskeleton, it mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. It ...
TMPK-00423	CD45 Protein, Human, Recombinant (His & Avi) CD45R,LY5,EC 3.1.3.48,B220,CD45,T...	Human	HEK293 Cells
	PTPRC (also known as CD45),T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) complex. CD45 ativates Lck by opposing the negative regulatory kinase Csk. Paradoxically, CD45 has also been implicated in suppressing TCR signaling by dephosphorylating the same signaling motifs within the TCR complex upon which Lck acts. CD45 Protein, Human, Recombinant (His & Avi...
TMPY-04754	CASK Protein, Human, Recombinant CMG,LIN2,MRXSNA,CAMGUK,calcium/calmodulin-dependent serine p...	Human	Baculovirus Insect Cells
	CASK Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 102.1 kDa and the accession number is O14936-4.
TMPY-00225	CLEC9A Protein, Mouse, Recombinant (hFc) C-type lectin domain family 9, member A,9830005G06Rik,DNGR-1	Mouse	HEK293 Cells
	CLEC9A Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 52.1 kDa and the accession number is Q8BRU4-4.
TMPY-01117	MRAP Protein, Human, Recombinant (hFc) FALP,FGD2,melanocortin 2 receptor accessory protein,GCCD2,B2...	Human	HEK293 Cells
	MRAP (Melanocortin 2 Receptor Accessory Protein) is a Protein Coding gene. This gene encodes a melanocortin receptor-interacting protein. It belongs to the MRAP family. MRAP, which contains a single transmembrane domain, has a unique structure, an antiparallel homodimer. MRAP is a single transmembrane domain accessory protein and a critical component of the hypothamo pituitary-adrenal axis. MRAP is highly expressed in the adrenal gland and is essential for adrenocorticotropin hormone (ACTH) rece...
TMPJ-00782	Amyloid Precursor Protein, Human, Recombinant (hFc) Amyloid Precursor,Amyloid Precursor Protein 695,APP695	Human	HEK293 Cells
	Amyloid precursor protein (APP) is a type I membrane protein with several isoforms due to alternative splicing, performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Of the three major splice isoforms of APP (APP695, APP751, and APP770) APP695 is the predominant neuronal form from which Amyloid beta peptide and transcriptionally-active cleaved intracellular domain of APP (AICD) are preferentially generated by selective process...
TMPJ-00233	CD200R1/CRTR2 Protein, Human, Recombinant (His) Cell Surface Glycoprotein CD200 Receptor 1,OX2R,MOX2R,CD200 ...	Human	HEK293 Cells
	Cell surface glycoprotein CD200 Receptor 1 (CD200R1) is the receptor for the CD200 (OX-2) membrane glycoprotein. CD200R1 contains one C2- type Ig-like domain and one V-type Ig-like domain within its extracellular domain and a PTB-signaling motif in cytoplasmic domain. CD200R1 and CD200 associate via their respective N-terminal Ig-like domains. CD200R1 is restricted primarily to mast cells, basophils, macrophages, and dendritic cells. It propagates inhibitory signals despite its lacking a cytopla...
TMPY-01823	PTK9 Protein, Human, Recombinant MGC41876,twinfilin actin binding protein 1,A6,MGC23...	Human	E. coli
	PTK9 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 29 kDa and the accession number is Q12792-4.
TMPY-01033	IL-32 Protein, Human, Recombinant (isoform alpha, His) IL-32δ,IL-32beta,IL32,TAIFc,IL-32γ,白介素,IL-32 Protein(isoform...	Human	HEK293 Cells
	IL-32 is a recently discovered cytokine that induces various proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and chemokines in both human and mouse cells through the NF-kappaB and p38 MAPK inflammatory signal pathways. It is regulated robustly by other major proinflammatory cytokines and is crucial to inflammation and immune responses. Four of the IL-32 isoforms (alpha, beta, gamma, and delta) are the most representative IL-32 transcripts, and the gamma isoform of IL-32 is the most active,...
TMPY-00119	FLT1 Protein, Human, Recombinant (hFc) VEGFR1,VEGFR-1,fms-related tyrosine kinase 1,FLT-1,FLT	Human	HEK293 Cells
	FLT1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.1 kDa and the accession number is P17948-4.
TMPK-00702	ANTXR2 Protein, Human, Recombinant (His) cI-35,Antxr2,JHS,CMG-2,CMG2,JHF,HFS,ISH	Human	HEK293 Cells
	The Capillary Morphogenesis Gene 2 (CMG2) gene encodes an Anthrax toxin receptor (ANTXR2),ANTXR2/CMG2 was originally identified as a result of up-regulation during capillary morphogenesis of endothelial cells (ECs) cultured in vitro. ANTXR2/CMG2 functions to promote endothelial proliferation and morphogenesis during sprouting angiogenesis, consistent with the endothelial expression of ANTXR2/CMG2 in several vascular beds.
TMPY-04565	SRPK3 Protein, Human, Recombinant (His & GST) MSSK1,MGC102944,STK23,MSSK-1,SRSF protein ...	Human	Baculovirus Insect Cells
	Serine / threonine-protein kinase SRPK3, also known as Muscle-specific serine kinase 1, Serine/arginine-rich protein-specific kinase 3, SR-protein-specific kinase 3, Serine / threonine-protein kinase 23, MSSK-1, SRPK3 and MSSK1, is a member of the protein kinase superfamily and CMGC Ser / Thr protein kinase family. SRPK3 is a protein kinase belonging to serine/arginine protein kinases (SRPK) family, which phosphorylates serine / arginine repeat-containing proteins, and is controlled by a muscle-...
TMPY-04563	CASK Protein, Human, Recombinant (His & GST) calcium/calmodulin-dependent serine protein kinase (MAGUK fa...	Human	Baculovirus Insect Cells
	CASK Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 130 kDa and the accession number is O14936-4.
TMPY-01822	PTK9 Protein, Human, Recombinant (His & GST) PTK9,MGC41876,A6,MGC23788,twinfilin actin binding p...	Human	E. coli
	PTK9 Protein, Human, Recombinant (His & GST) is expressed in E. coli expression system with His and GST tag. The predicted molecular weight is 57 kDa and the accession number is Q12792-4.
TMPY-01933	CHI3L2 Protein, Human, Recombinant (His) YKL-39,CHIL2,chitinase 3 like 2,YKL39	Human	HEK293 Cells
	Chondrocyte protein 39 (YKL-39), also known as Chitinase 3-like 2 (CHI3L2), is a secretory protein of articular chondrocytes belonging to the glycosyl hydrolase 18 family. Its highest expression is in chondrocytes, followed by synoviocytes, lung and heart. YKL-39/CHI3L2 is not detected in spleen, pancreas, and liver. YKL-39/CHI3L2 may also be expressed in developing brain and placenta. YKL-39/CHI3L2, a cartilage-related protein, is found to induce arthritis accompanied by pathologic changes in b...
TMPY-00380	ANTXR2 Protein, Human, Recombinant (hFc) HFS,JHF,anthrax toxin receptor 2,ISH,CMG-2,CMG2	Human	HEK293 Cells
	ANTXR2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 57.4 kDa and the accession number is P58335-4.
TMPY-00711	CD45 Protein, Human, Recombinant (hFc) GP180,L-CA,LY5,T200,protein tyrosine phosphatase, receptor t...	Human	HEK293 Cells
	CD45 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 71.1 kDa and the accession number is P08575-4.
TMPJ-00410	CD45R0 Protein, Human, Recombinant (His) CD45 antigen,L-CA,protein tyrosine phosphatase, rec...	Human	HEK293 Cells
	CD45R0 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 80-120 KDa and the accession number is P08575-4.
TMPJ-01256	Caspase-10 Protein, Human, Recombinant (His) CASP10,FAS-Associated Death Domain Protein Interleukin-1B-Co...	Human	E. coli
	Caspase-10 (CASP10) is a 521 amino acid protein member of the Cysteine-Aspartic Acid Protease (Caspase) family. CASP10 contains two DED (Death Effector) domains and is detectable in most tissues. CASP10 cleavage by Granzyme B and autocatalytic activity generate the two active subunits: Caspase-10 subunit p23/17, Caspase-10 subunit p12. Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the execution-phase of cell apoptosis, the initiation and execution. Human ca...
TMPJ-01188	CORO6 Protein, Human, Recombinant (His) Coronin-6,Clipin-E,CORO6	Human	E. coli
	Coronin 6, a newly identified member of the coronin family, is highly enriched at adult NMJs and regulates AChR clustering via modulating the interaction between receptors and the actin cytoskeletal network. Coronins are a family of conserved actin-binding proteins originally identified in the actin-rich structure of the amoeba Dictyostelium discoideum . To date, seven members of coronins have been identified in mammals, and most exhibit tissue-specific distribution patterns. Coronin 6 is promin...
TMPK-01362	SIRP alpha V4 Protein, Human, Recombinant (His & Avi), Biotinylated MYD1,SIRP α V4,PTPNS1,BIT,SHPS1,SIRP alpha,SHPS-1,S...	Human	HEK293 Cells
	Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. SIRP alpha V4 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian c...
TMPK-01356	SIRP alpha V4 Protein, Human, Recombinant (His & Avi) BIT,SIRP α V4,MFR,SHPS1,SIRPA,SIRP α,P84,M...	Human	HEK293 Cells
	Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. SIRP alpha V4 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-Hi...

重组蛋白

FGF-2 Protein, Human, Recombinant

Cat.No: TMPY-00749

Species: Human

Expression System: E. coli

VEGF165 Protein, Human, Recombinant

Cat.No: TMPJ-00864

Species: Human

Expression System: HEK293 Cells

VEGF165 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00823

Species: Human

Expression System: HEK293 Cells

VEGF165 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-04911

Species: Human,Cynomolgus

Expression System: HEK293 Cells

NT5C3A/NT5C3 Protein, Human, Recombinant

Cat.No: TMPY-02893

Species: Human

Expression System: E. coli

CD45 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00424

Species: Human

Expression System: HEK293 Cells

VEGF165 Protein, Human, Recombinant (His & Avi), FITC-Labeled

Cat.No: TMPK-00822

Species: Human

Expression System: HEK293 Cells

Siglec-2/CD22 Protein, Human, Recombinant (hFc & Avi), Biotinylated

Cat.No: TMPY-05598

Species: Human

Expression System: HEK293 Cells

APEG1 Protein, Human, Recombinant (His)

Cat.No: TMPY-04471

Species: Human

Expression System: E. coli

TEM8/ANTXR1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01333

Species: Human

Expression System: HEK293 Cells

CD45 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00423

Species: Human

Expression System: HEK293 Cells

CASK Protein, Human, Recombinant

Cat.No: TMPY-04754

Species: Human

Expression System: Baculovirus Insect Cells

CLEC9A Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-00225

Species: Mouse

Expression System: HEK293 Cells

MRAP Protein, Human, Recombinant (hFc)

Cat.No: TMPY-01117

Species: Human

Expression System: HEK293 Cells

Amyloid Precursor Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00782

Species: Human

Expression System: HEK293 Cells

CD200R1/CRTR2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00233

Species: Human

Expression System: HEK293 Cells

PTK9 Protein, Human, Recombinant

Cat.No: TMPY-01823

Species: Human

Expression System: E. coli

IL-32 Protein, Human, Recombinant (isoform alpha, His)

Cat.No: TMPY-01033

Species: Human

Expression System: HEK293 Cells

FLT1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00119

Species: Human

Expression System: HEK293 Cells

ANTXR2 Protein, Human, Recombinant (His)

Cat.No: TMPK-00702

Species: Human

Expression System: HEK293 Cells

SRPK3 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04565

Species: Human

Expression System: Baculovirus Insect Cells

CASK Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04563

Species: Human

Expression System: Baculovirus Insect Cells

PTK9 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-01822

Species: Human

Expression System: E. coli

CHI3L2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01933

Species: Human

Expression System: HEK293 Cells

ANTXR2 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00380

Species: Human

Expression System: HEK293 Cells

CD45 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00711

Species: Human

Expression System: HEK293 Cells

CD45R0 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00410

Species: Human

Expression System: HEK293 Cells

Caspase-10 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01256

Species: Human

Expression System: E. coli

CORO6 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01188

Species: Human

Expression System: E. coli

SIRP alpha V4 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-01362

Species: Human

Expression System: HEK293 Cells

SIRP alpha V4 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-01356

Species: Human

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0249	Crisaborole-d4
	Crisaborole-d4 是 Crisaborole 的氘代化合物。Crisaborole 的 CAS 号为 906673-24-3。Crisaborole 是一种有效的 PDE4和cytokine释放抑制剂，能够抑制PDE4(IC50=0.49 μM)。
TMIH-0190	Difamilast-d5
	Difamilast-d5 是 Difamilast 的氘代化合物。Difamilast 的 CAS 号为 937782-05-3。Difamilast 是局部的、选择性的非甾体磷酸二酯酶 4 抑制剂，对 B 亚型抑制作用较好 (IC50=11.2 nM)。它在研究轻度至中度特应性皮炎方面有研究的价值。
T70883	Moexipril-d5
	Moexipril-d5 intended for use as an internal standard for the quantification of moexipril by GC- or LC-MS. Moexipril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor moexiprilat. It is converted to moexiprilat in vivo by side chain ester hydrolysis. Moexipril inhibits ACE in a cell-free assay (IC50 = 2.7 µM for the rabbit enzyme). It also inhibits phosphodiesterase 4 (IC50s = 38, 160, and 230 µM for PDE4B2, PDE4A5 and PDE4D5, respectively). Moexipril (0.1-30 mg/kg per day) ...
TMIJ-0114	Vardenafil-d5
	Vardenafil-d5 是 Vardenafil 的氘代化合物。Vardenafil 的 CAS 号为 224785-90-4。Vardenafil 是选择性、高效的、具有口服活性的磷酸二酯酶5抑制剂，IC50=0.7 nM。它能够非竞争性地抑制环磷酸鸟苷水解，从而提高 cGMP 水平。它对 PDE1 (180 nM)，PDE6 (11 nM)，PDE2，PDE3，PDE4 (>1000 nM) 具有选择性。它可用于研究勃起功能障碍。

同位素标记化合物

Cat.No: TMIJ-0249

Cat.No: TMIH-0190

Cat.No: T70883

Cat.No: TMIJ-0114

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